CN104013878B - A kind of lavipeditum medicine vinegar and preparation method thereof for treating tinea pedis - Google Patents
A kind of lavipeditum medicine vinegar and preparation method thereof for treating tinea pedis Download PDFInfo
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Abstract
The present invention relates to pharmaceutical technology field, a kind of lavipeditum medicine vinegar of quick treatment tinea pedis and preparation method thereof is disclosed.Lavipeditum medicine vinegar of the present invention is made of medicine vinegar liquid and antibacterial powder, the medicine vinegar liquid is made of medicine vinegar liquid and antibacterial powder, and the medicine vinegar liquid is made of Cortex Phellodendri, kuh-seng, corter pseudolaricis, Chinese prickly ash, 95% ethyl alcohol, acetic acid, peppermint, benzoic acid, glycerine, 75% second alcohol and water；The antibacterial powder is made of alum, boric acid, smilax, salt, talcum powder.The present invention optimizes Chinese medicine preparation, and by the way of Integrated TCM, lavipeditum medicine vinegar is divided into medicine vinegar liquid and antibacterial powder two parts, not only solves drug stability problems, and reach rapid-action, cure rate is high, without recurrence, and the effect non-stimulated to skin.
Description
Technical field
The present invention relates to pharmaceutical technology fields, particularly relate to a kind of the lavipeditum medicine vinegar and its system of quick treatment tinea pedis
Preparation Method.
Background technology
Tinea pedis is being commonly called as tinea pedis, also known as " athlete's foot ", is the foot dermatosis caused by pathogenic fungus, the torrid zone and
Subtropical zone is generally popular, different according to the symptom of clinical manifestation, and tinea pedis is divided into four types：Type, the scales of skin that peel off between pompholyx type, toe
Keratinization type and moistening erosive type.China's Chinese medicine tinea pedis is referred to as " tinea pedis ", " river snail sore ", is damp invasion of lower energizer or occupies wetland contamination long
It is caused.Theory of traditional Chinese medical science thinks that the pathogenesis of tinea pedis is wind, wet, hot, worm invasion skin, and wet poison accumulates resistance skin and causes dipping rotten to the corn,
Sick damp and hot dryness-transformation long injures qi and blood, failure of skin and muscle to be nourished, then drying, furfur, chap etc..
Some cities in south China, tinea pedis incidence are up to 80%.Tinea pedis incidence height and foot anatomical features have
It closes, including foot sweat gland is abundant, more, no sebaceous glands of perspiring, skin surface meta-alkalescence is conducive to fungi and grows, and vola position
Cuticula relatively thickness provides abundant nutrition for fungi.China tinea of feet and hands pathomycete is mainly Trichophyton rubrum, Epidermophvton
Tinea bacterium and size roe deer bacterium etc..They are easy breeding under suitable temperature (25-30 degree), humidity, acidity (pH value 5-7).
After invading skin, clinical manifestation is fungi diagonalization tissue coup injury, causes inflammation to change at damage edge, has and obviously itch
Sense.By rubbing and scratching, it can cause interdigit dipping and erosion, chronic cases that pachyderma, hyperkeratinization can be caused to enter the winter
It then chaps, summer easily recurrence again seriously affects work and study.
Not only incidence is high for tinea pedis, and has very strong infectiousness.If do not treated in time to symptoms such as itch, easily certainly
Body infect and formed ringworm of the body, onychomycosis even internal deep infection, also can by contact contagion other people, therefore prevent tinea pedis ten
Divide necessity.For treating beri-beri drug based on being put on the skin outside ointment, spray, there are also steep foot medicinal powder, but all Shortcomings in the market.Such as
Most common ZUGUANG SAN on the market, the drug are the conventional variety for treating Keratotic tinea hand or pedis and bromhidrosis in the market, technology and
Standard comes from State Food and Drug Administration's national drug standards, standard number： WS-10344(ZD-0344)-
2002-2011Z, formula, preparation method and usage are as follows：
Formula and preparation method：180 grams of salicylic acid, 120 grams of benzoic acid, 400 grams of boric acid, 200 grams of kuh-seng, 100 grams of talcum powder, will
The above drug pulverizes and sieves, and mixes, stirs evenly, and is made into 1000 grams, and every bag dispenses 40 grams.
Usage：It takes one bag of medicine to set in basin every time, adds 1000-1500 milliliters of boiling water, stir, temperature is put in dissolving, impregnates suffer from while hot
Place 20-30 minutes, once a day, continuous 3 days as a treatment course.
The full side of ZUGUANG SAN only kuh-seng a herb, though there is heat-clearing and damp-drying drug, desinsection itching-relieving efficacies are un-extracted, directly with
Medicinal material beats powder and is used as medicine, and active ingredient is difficult to be transferred out from medicinal material penetrates into lesion again；And salicylic acid is typical cutin
Medicine is stripped off, larger to skin irritation, 80% or more patient has apparent scurf to fall off after, and text is also marked in specification
It offers report and once causes contact dermatitis, there is serious dermatitis individually.Square ingredient antibacterial action is limited entirely for ZUGUANG SAN, only relies on decortication and comes
Curative effect is maintained, it is higher individually to carry out lavipeditum treatment recurrence rate with this side.In addition, specification clear stipulaties vesicle, erosive type hand
Tinea pedis disables, and only adapts to scales of skin that peel off Keratotic tinea hand or pedis and bromhidrosis.
Chinese patent CN102429990 discloses a kind of vinegar and the antipruritic bubble foot vinegar for controlling tinea pedis of Chinese medicine combination deodorization and its matches
Method processed is original with kuh-seng, oriental wormwood, Cortex Phellodendri, pericarpium zanthoxyli, Radix Angelicae Pubescentis, erythrina bark, the root bark of shaggy-fruited dittany, the fruit of summer cypress, Radix Angelicae Sinensis, Radix Glycyrrhizae and vinegar
Material is prepared using water extraction.But there are also defects for the patent formula.First, the bubble foot vinegar course for the treatment of up to 30 days or more,
It works slow, of long duration, patient is difficult to adhere to continuous use, and intermittent medication also easily causes the drug resistance of germ；Second, analysis
Its prescription can play preferable comprehensively regulating health care and make it is found that each traditional Chinese medicine ingredients have heat-clearing, dehumidifying, promoting blood circulation, antipruritic effect
With, however the pathogenesis of tinea pedis is skin infection caused by the pathomycetes such as Trichophyton rubrum, acrothesium floccosum, the party
Antibiotic effect is insufficient；Third, it is imappropriate using extraction process by water.Lot of documents shows the tinea of feet and hands caused by treating fungal infection
In prescription, kuh-seng, Cortex Phellodendri frequency of use highest illustrate that its antifungic action is widely recognized as.Chemistry in both medicinal materials
Ingredient is mainly alkaloid, and Cortex Phellodendri is containing jamaicin, phellodendrine, jateorrhizine etc., and kuh-seng is containing matrine, oxymatrine etc..Medicinal material
In most of alkaloids exist with acylate and free alkali, solubility generally in water is all smaller, and water extraction extraction can not
The effect of obtaining enough antimicrobial components, influencing product.
Invention content
In view of this, the purpose of the present invention is to provide a kind of lavipeditum medicine vinegar of quick treatment tinea pedis and preparation method thereof,
So that the lavipeditum medicine vinegar prepared by the present invention to tinea pedis, especially works to scales of skin that peel off keratinization type tinea pedis and moistening erosive beriberi
Soon, cure rate it is high, without recurrence, and it is non-stimulated to skin.
Another object of the present invention is to provide a kind of lavipeditum medicine vinegar of quick treatment tinea pedis and preparation method thereof, makes
Prepared lavipeditum medicine vinegar Antibacterial Constituents content is obtained to be improved.
Another object of the present invention is to provide a kind of lavipeditum medicine vinegar of quick treatment tinea pedis and preparation method thereof, makes
It is more preferable to obtain prepared lavipeditum medicine vinegar stability.
To achieve the goals above, the present invention provides the following technical solutions：
A kind of lavipeditum medicine vinegar of quick treatment tinea pedis, is made of, the medicine vinegar liquid is by Cortex Phellodendri, hardship medicine vinegar liquid and antibacterial powder
Ginseng, corter pseudolaricis, Chinese prickly ash, 95% ethyl alcohol, acetic acid, peppermint, benzoic acid, glycerine, 75% second alcohol and water are made；
The antibacterial powder is made of alum, boric acid, smilax, salt, talcum powder.
For the defects of existing medicine vinegar product action for treating tinea pedis is slow, cure rate is low, irritant, stability is poor, originally
Invention optimization Chinese medicine preparation, and by the way of Integrated TCM, lavipeditum medicine vinegar is divided into medicine vinegar liquid and antibacterial powder two parts, no
But solve drug stability problems, and reach rapid-action, cure rate is high, without recurrence, and the effect non-stimulated to skin.
Medicine vinegar liquid of the present invention obtains kuh-seng, Cortex Phellodendri, corter pseudolaricis, Pericarpium Zanthoxyli extract, cooperation benzoic acid, thin using mixed solvent
Lotus, glycerine, ethyl alcohol collaboration reach clearing heat and detoxicating, and eliminating dampness dredges pore, improve microcirculation antiulcer, and enhancing anti-mycotic efficiency increases
Effect；Antibacterial powder of the present invention reaches antibacterial, convergence, hidroschesis, solution using alum, boric acid, smilax, salt, talcum powder, synergistic effect
Poison dehumidifies, subsides a swelling, go foot odour, is antipruritic, clearing damp sore, maintaining the effect of skin.Medicine vinegar liquid and antibacterial powder are with the use of fully hair
Chinese and western drugs respectively advantage is waved, the work(of antibacterial desinsection, the hidroschesis that dehumidifies is played in complementary synergy altogether, and impaired skin update can be accelerated to repair,
It enables skin clearly smooth, is suitable for various types of tinea pedis.
Medicine vinegar liquid and antibacterial powder can be added to boiling water together and carry out lavipeditum treatment by the present invention, can also be individually by medicine vinegar
Liquid lavipeditum, then antibacterial powder is directly spread on to affected part convergence hidroschesis, medicine vinegar liquid or antibacterial powder can also be sprayed on to shoe-sock sterilizing suppression
Bacterium.Wherein most fast to the healing in tinea pedis affected part with the first usage, 3 kinds of method synthesis use, and general effect is best.
Preferably, every liter of medicine vinegar liquid is made of following raw material：
10-30 portions of Cortex Phellodendris, 10-30 parts of kuh-sengs, 10-30 parts of corter pseudolaricis, 1-10 portions of Chinese prickly ashes, 95% ethyl alcohol of 350-650 parts,
180-300 parts of acetic acid, 120-200 parts of water, 1-5 portions of peppermints, 10-30 parts of benzoic acid, 10-80 parts of glycerine, 75% ethyl alcohol of surplus are mended
Enough to 1L.
In some embodiment of the invention, every liter of medicine vinegar liquid is made of following raw material：
20 portions of Cortex Phellodendris, 15 parts of kuh-sengs, 20 parts of corter pseudolaricis, 5 portions of Chinese prickly ashes, 500 part of 95% ethyl alcohol, 240 parts of acetic acid, 160 parts
Water, 2 portions of peppermints, 20 parts of benzoic acid, 50 parts of glycerine, 75% ethyl alcohol of surplus complement to 1L.
Alternatively, 10 portions of Cortex Phellodendris, 10 parts of kuh-sengs, 10 parts of corter pseudolaricis, 1 portion of Chinese prickly ash, 450 part of 95% ethyl alcohol, 180 parts of acetic acid,
120 parts of water, 1 portion of peppermint, 10 parts of benzoic acid, 80 parts of glycerine, 75% ethyl alcohol of surplus complement to 1L.
Alternatively, 30 portions of Cortex Phellodendris, 30 parts of kuh-sengs, 30 parts of corter pseudolaricis, 10 portions of Chinese prickly ashes, 550 part of 95% ethyl alcohol, 300 parts of acetic acid,
200,5 portions of peppermints, 30 parts of benzoic acid, 10 parts of glycerine, 75% ethyl alcohol of surplus complement to 1L.
Alternatively, 25 portions of Cortex Phellodendris, 25 parts of kuh-sengs, 25 parts of corter pseudolaricis, 7 portions of Chinese prickly ashes, 550 part of 95% ethyl alcohol, 270 parts of acetic acid, 180
Part water, 4 portions of peppermints, 25 parts of benzoic acid, 40 parts of glycerine, 75% ethyl alcohol of surplus complement to 1L.
In the raw material of medicine vinegar liquid of the present invention, 95% ethyl alcohol is divided into two parts in specific prepare and uses, and one
Part forms mixed solvent to Cortex Phellodendri, kuh-seng, corter pseudolaricis, Chinese prickly ash Soakage extraction with acetic acid, water, and the volume ratio of three is preferably
95% ethyl alcohol：Acetic acid：Water=5:3:2；Remainder is for dissolving other substances use.
For of the present invention in parts by weight it should be noted that each raw material of the present invention had not only contained solid material but also contained
Liquid charging stock, solid material and liquid charging stock are numerically identical represented by every parts by weight, but unit is still according to solid and liquid
Respectively unit indicates body raw material, and by taking solid material indicates 1g (1kg) per parts by weight as an example, corresponding liquid charging stock is per parts by weight
1mL (1L) is corresponded to, if solid material indicates that 2g (2kg), corresponding liquid charging stock correspond to 2mL per parts by weight per parts by weight
(2L), glycerine is in the present invention based on solid material.Unless there are specified otherwise, described in parts by weight according to this in the present invention
It explains.
Preferably, each raw material of antibacterial powder is in parts by weight：
100-400 parts of alum, 100-300 parts of boric acid, 100-300 parts of smilax, 100-300 parts of salt, talcum powder 100-
400 parts.
In some embodiments of the invention, each raw material of the antibacterial powder is in parts by weight：
300 parts of alum, 200 parts of boric acid, 200 parts of smilax, 150 parts of salt, 150 parts of talcum powder.
Alternatively, 200 parts of alum, 150 parts of boric acid, 150 parts of smilax, 100 parts of salt, 400 parts of talcum powder.
Alternatively, 100 parts of alum, 100 parts of boric acid, 100 parts of smilax, 300 parts of salt, 100 parts of talcum powder.
Alternatively, 400 parts of alum, 300 parts of boric acid, 300 parts of smilax, 200 parts of salt, 300 parts of talcum powder.
Preferably, the volume mass ratio of the medicine vinegar liquid and antibacterial powder is 100mL:20-30g.
In addition, the present invention also provides a kind of preparation methods of lavipeditum medicine vinegar that treating tinea pedis, including：
4 kinds of Cortex Phellodendri, kuh-seng, corter pseudolaricis, Chinese prickly ash pulverizing medicinal materials are taken, solvent is added and impregnates 2 times, the solvent is 95% second
The mixed solvent of alcohol, acetic acid and water composition, merges 2 filtrates, obtains extracting solution；Benzoic acid, peppermint are dissolved in residue 95%
In ethyl alcohol, glycerine mixing is added, is then added in said extracted liquid, stirs evenly, 1L is settled to 75% ethyl alcohol, is mixed
Uniformly, medicine vinegar liquid is obtained；
Alum, boric acid, smilax, salt, talcum powder are respectively crushed into fine powder, cross 60 mesh sieve, is then mixed equal
It is even, obtain antibacterial powder；
The medicine vinegar liquid and antibacterial powder form lavipeditum medicine vinegar.
Preferably, every liter of medicine vinegar liquid is made of following raw material：
10-30 portions of Cortex Phellodendris, 10-30 parts of kuh-sengs, 10-30 parts of corter pseudolaricis, 1-10 portions of Chinese prickly ashes, 95% ethyl alcohol of 350-650 parts,
180-300 parts of acetic acid, 120-200 parts of water, 1-5 portions of peppermints, 10-30 parts of benzoic acid, 10-80 parts of glycerine, 75% ethyl alcohol of surplus are mended
Enough to 1L.
In some embodiment of the invention, every liter of medicine vinegar liquid is made of following raw material：
20 portions of Cortex Phellodendris, 15 parts of kuh-sengs, 20 parts of corter pseudolaricis, 5 portions of Chinese prickly ashes, 500 part of 95% ethyl alcohol, 240 parts of acetic acid, 160 parts
Water, 2 portions of peppermints, 20 parts of benzoic acid, 50 parts of glycerine, 75% ethyl alcohol of surplus complement to 1L.
Alternatively, 10 portions of Cortex Phellodendris, 10 parts of kuh-sengs, 10 parts of corter pseudolaricis, 1 portion of Chinese prickly ash, 450 part of 95% ethyl alcohol, 180 parts of acetic acid,
120 parts of water, 1 portion of peppermint, 10 parts of benzoic acid, 80 parts of glycerine, 75% ethyl alcohol of surplus complement to 1L.
Alternatively, 30 portions of Cortex Phellodendris, 30 parts of kuh-sengs, 30 parts of corter pseudolaricis, 10 portions of Chinese prickly ashes, 550 part of 95% ethyl alcohol, 300 parts of acetic acid,
200,5 portions of peppermints, 30 parts of benzoic acid, 10 parts of glycerine, 75% ethyl alcohol of surplus complement to 1L.
Alternatively, 25 portions of Cortex Phellodendris, 25 parts of kuh-sengs, 25 parts of corter pseudolaricis, 7 portions of Chinese prickly ashes, 550 part of 95% ethyl alcohol, 270 parts of acetic acid,
180 parts of water, 4 portions of peppermints, 25 parts of benzoic acid, 40 parts of glycerine, 75% ethyl alcohol of surplus complement to 1L.
Preferably, the volume ratio of 95% ethyl alcohol, acetic acid and water is 5 in the mixed solvent:3:2.
Preferably, each raw material of antibacterial powder is in parts by weight：
100-400 parts of alum, 100-300 parts of boric acid, 100-300 parts of smilax, 100-300 parts of salt, talcum powder 100-
400 parts.
In some embodiments of the invention, each raw material of the antibacterial powder is in parts by weight：
300 parts of alum, 200 parts of boric acid, 200 parts of smilax, 150 parts of salt, 150 parts of talcum powder.
Alternatively, 200 parts of alum, 150 parts of boric acid, 150 parts of smilax, 100 parts of salt, 400 parts of talcum powder.
Alternatively, 100 parts of alum, 100 parts of boric acid, 100 parts of smilax, 300 parts of salt, 100 parts of talcum powder.
Alternatively, 400 parts of alum, 300 parts of boric acid, 300 parts of smilax, 200 parts of salt, 300 parts of talcum powder.
Preferably, the volume mass ratio of the medicine vinegar liquid and antibacterial powder is 100mL:20-30g.
Preferably, addition solvent of the present invention impregnates 2 times specially：
400-600 parts by weight solvents are added for the first time to impregnate 72 hours, filtration；Second of addition 200-400 weight of filter residue
Part solvent impregnates 48 hours, filtration.
The present invention is extracted using different solvents with 4 kinds of Cortex Phellodendri, kuh-seng, corter pseudolaricis, Chinese prickly ash Chinese medicines are compared, as a result table
It is bright with pure water, the mixed solvent of pure 95% ethyl alcohol, non-present invention proportioning extract, jamaicin, matrine, oxymatrine
Content is below the content for the mixed solvent extraction that proportioning is limited according to the present invention.Meanwhile using medicine vinegar liquid raw material of the present invention,
Water extraction is carried out according to the method for existing patent CN102429990 embodiments 1, the results show that jamaicin, matrine, oxidation hardship
The content of ginseng alkali is still below the content of each active constituent in the medicine vinegar liquid prepared according to the present invention, and goes out in medicine vinegar liquid clarity
Existing muddiness, stability are poor.
In the cure rate experiment of the product prepared with existing patent CN102429990 embodiments 1, product of the present invention is 10
It total cure rate reaches 90% or more, and the total cure rate of existing patent only reaches 65% or so, from the side illustration present invention
The product is rapid-action, takes short.
Lavipeditum medicine vinegar product prepared by the present invention through disease prevention and control center of Hunan Province according to《Disinfection technology standard》
The regulation of (version in 2002) carries out stimulate the reaction scoring and stimulus intensity evaluation, and lavipeditum medicine vinegar stimulus index of the present invention is 0.167,
Belong to nonirritant.
By above technical scheme it is found that the present invention optimizes Chinese medicine preparation, and by the way of Integrated TCM, by lavipeditum medicine
Vinegar is divided into medicine vinegar liquid and antibacterial powder two parts, not only solves drug stability problems, and reach rapid-action, cure rate is high, nothing
Recurrence, and the effect non-stimulated to skin.
Specific implementation mode
The embodiment of the invention discloses a kind of lavipeditum medicine vinegar of quick treatment tinea pedis and preparation method thereof.People in the art
Member can use for reference present disclosure, be suitably modified technological parameter realization.In particular, it should be pointed out that all similar substitutions and modifications
Apparent to those skilled in the art, they are considered as being included in the present invention.The product and method of the present invention
Be described by preferred embodiment, related personnel obviously can not depart from the content of present invention, in spirit and scope it is right
Product as described herein and method are modified or suitably change and combine, to realize and apply the technology of the present invention.
According to the technical solution that the present invention describes, lavipeditum medicine vinegar usage and dosage of the present invention is as follows：
External application foot bath：Once a day.20-30 grams of antibacterial powder is taken, is set in foot washing basin, 700 milliliters of boiling water is added, is stirred, dissolving,
About after five minutes, 100 milliliters of medicine vinegar liquid is added, while hot impregnates both feet 20-30 minutes.It is cleaned after.
Spraying：It takes medicine vinegar liquid to be sprayed at affected part, three times per day, separately takes antibacterial powder to be directly spread at moistening erosion, or a small amount of
It is spread on footgear, with comprehensive bacteriostasis, and deodorization.
For a further understanding of the present invention, with reference to embodiment to a kind of foot of quick treatment tinea pedis provided by the invention
Bath medicine vinegar and preparation method thereof is described in detail.
Embodiment 1：Preparing lavipeditum medicine vinegar of the present invention, (for solid material per parts by weight 1g, liquid charging stock is per parts by weight
1mL)
Medicine vinegar liquid bulk pharmaceutical chemicals：20 portions of Cortex Phellodendris, 15 parts of kuh-sengs, 20 parts of corter pseudolaricis, 5 portions of Chinese prickly ashes, 500 part of 95% ethyl alcohol are (wherein
400 parts be used for mixed solvent), 240 parts of acetic acid, 160 parts of water, 2 portions of peppermints, 20 parts of benzoic acid, 50 parts of glycerine, appropriate 75% second
Alcohol；
Antibacterial powder bulk pharmaceutical chemicals：300 parts of alum, 200 parts of boric acid, 200 parts of smilax, 150 parts of salt, 150 parts of talcum powder.
It is prepared by medicine vinegar liquid：It takes 4 kinds of Cortex Phellodendri, kuh-seng, corter pseudolaricis, Chinese prickly ash pulverizing medicinal materials at coarse granule, solvent dipping 2 is added
Secondary, volume ratio is 95% ethyl alcohol：Acetic acid：Water=5:3:2,500 parts by weight solvents are added for the first time, impregnate 72 hours, filtration；
Second of addition 300 parts by weight solvent of solvent of filter residue impregnates 48 hours, and filtration merges 2 filtrates, stands 24 hours, then smart
Filter, obtains brown color extracting solution；Benzoic acid, menthol, essence are dissolved in the ethyl alcohol of residue 95%, add glycerine mixing, so
After be added in said extracted liquid, stir evenly, be settled to 1000ml with 75% ethyl alcohol, obtain medicine vinegar liquid.
It is prepared by antibacterial powder：Alum, boric acid, smilax, salt, talcum powder are respectively crushed into fine powder, cross 60 mesh sieve, then
It is mixed evenly, obtains antibacterial powder.
Lavipeditum medicine vinegar product manufactured in the present embodiment through disease prevention and control center of Hunan Province according to《Disinfection technology standard》
The regulation of (version in 2002) carries out stimulate the reaction scoring and stimulus intensity evaluation, and the present embodiment lavipeditum medicine vinegar stimulus index is
0.167, belong to nonirritant.
Embodiment 2：Preparing lavipeditum medicine vinegar of the present invention, (for solid material per parts by weight 1g, liquid charging stock is per parts by weight
1mL)
Medicine vinegar liquid bulk pharmaceutical chemicals：10 portions of Cortex Phellodendris, 10 parts of kuh-sengs, 10 parts of corter pseudolaricis, 1 portion of Chinese prickly ash, 450 part of 95% ethyl alcohol are (wherein
300 parts be used for mixed solvent), 180 parts of acetic acid, 120 parts of water, 1 portion of peppermint, 10 parts of benzoic acid, 80 parts of glycerine, appropriate 75% second
Alcohol；
Antibacterial powder bulk pharmaceutical chemicals：200 parts of alum, 150 parts of boric acid, 150 parts of smilax, 100 parts of salt, 400 parts of talcum powder.
It is prepared by medicine vinegar liquid：It takes 4 kinds of Cortex Phellodendri, kuh-seng, corter pseudolaricis, Chinese prickly ash pulverizing medicinal materials at coarse granule, solvent dipping 2 is added
Secondary, volume ratio is 95% ethyl alcohol：Acetic acid：Water=5:3:2,400 parts by weight solvents are added for the first time, impregnate 72 hours, filtration；
Second of addition 200 parts by weight solvent of solvent of filter residue impregnates 48 hours, and filtration merges 2 filtrates, stands 24 hours, then smart
Filter, obtains brown color extracting solution；Benzoic acid, menthol, essence are dissolved in the ethyl alcohol of residue 95%, add glycerine mixing, so
After be added in said extracted liquid, stir evenly, be settled to 1000ml with 75% ethyl alcohol, obtain medicine vinegar liquid.
It is prepared by antibacterial powder：Alum, boric acid, smilax, salt, talcum powder are respectively crushed into fine powder, cross 60 mesh sieve, then
It is mixed evenly, obtains antibacterial powder.
Lavipeditum medicine vinegar product manufactured in the present embodiment through disease prevention and control center of Hunan Province according to《Disinfection technology standard》
The regulation of (version in 2002) carries out stimulate the reaction scoring and stimulus intensity evaluation, belongs to nonirritant.
Embodiment 3：Preparing lavipeditum medicine vinegar of the present invention, (for solid material per parts by weight 1g, liquid charging stock is per parts by weight
1mL)
Medicine vinegar liquid bulk pharmaceutical chemicals：30 portions of Cortex Phellodendris, 30 parts of kuh-sengs, 30 parts of corter pseudolaricis, 10 portions of Chinese prickly ashes, 550 part of 95% ethyl alcohol (its
In 500 parts be used for mixed solvent), 300 parts of acetic acid, 200 parts of water, 5 portions of peppermints, 30 parts of benzoic acid, 10 parts of glycerine, appropriate 75%
Ethyl alcohol；
Antibacterial powder bulk pharmaceutical chemicals：100 parts of alum, 100 parts of boric acid, 100 parts of smilax, 300 parts of salt, 100 parts of talcum powder.
It is prepared by medicine vinegar liquid：It takes 4 kinds of Cortex Phellodendri, kuh-seng, corter pseudolaricis, Chinese prickly ash pulverizing medicinal materials at coarse granule, solvent dipping 2 is added
Secondary, volume ratio is 95% ethyl alcohol：Acetic acid：Water=5:3:2,600 parts by weight solvents are added for the first time, impregnate 72 hours, filtration；
Second of addition 400 parts by weight solvent of solvent of filter residue impregnates 48 hours, and filtration merges 2 filtrates, stands 24 hours, then smart
Filter, obtains brown color extracting solution；Benzoic acid, menthol, essence are dissolved in the ethyl alcohol of residue 95%, add glycerine mixing, so
After be added in said extracted liquid, stir evenly, be settled to 1000ml with 75% ethyl alcohol, obtain medicine vinegar liquid.
It is prepared by antibacterial powder：Alum, boric acid, smilax, salt, talcum powder are respectively crushed into fine powder, cross 60 mesh sieve, then
It is mixed evenly, obtains antibacterial powder.
Lavipeditum medicine vinegar product manufactured in the present embodiment through disease prevention and control center of Hunan Province according to《Disinfection technology standard》
The regulation of (version in 2002) carries out stimulate the reaction scoring and stimulus intensity evaluation, belongs to nonirritant.
Embodiment 4：Preparing lavipeditum medicine vinegar of the present invention, (for solid material per parts by weight 1g, liquid charging stock is per parts by weight
1mL)
Medicine vinegar liquid bulk pharmaceutical chemicals：25 portions of Cortex Phellodendris, 25 parts of kuh-sengs, 25 parts of corter pseudolaricis, 7 portions of Chinese prickly ashes, 550 part of 95% ethyl alcohol are (wherein
450 parts be used for mixed solvent), 270 parts of acetic acid, 180 parts of water, 4 portions of peppermints, 25 parts of benzoic acid, 40 parts of glycerine, appropriate 75% second
Alcohol；
Antibacterial powder bulk pharmaceutical chemicals：400 parts of alum, 300 parts of boric acid, 300 parts of smilax, 200 parts of salt, 300 parts of talcum powder.
It is prepared by medicine vinegar liquid：It takes 4 kinds of Cortex Phellodendri, kuh-seng, corter pseudolaricis, Chinese prickly ash pulverizing medicinal materials at coarse granule, solvent dipping 2 is added
Secondary, volume ratio is 95% ethyl alcohol：Acetic acid：Water=5:3:2,500 parts by weight solvents are added for the first time, impregnate 72 hours, filtration；
Second of addition 400 parts by weight solvent of solvent of filter residue impregnates 48 hours, and filtration merges 2 filtrates, stands 24 hours, then smart
Filter, obtains brown color extracting solution；Benzoic acid, menthol, essence are dissolved in the ethyl alcohol of residue 95%, add glycerine mixing, so
After be added in said extracted liquid, stir evenly, be settled to 1000ml with 75% ethyl alcohol, obtain medicine vinegar liquid.
It is prepared by antibacterial powder：Alum, boric acid, smilax, salt, talcum powder are respectively crushed into fine powder, cross 60 mesh sieve, then
It is mixed evenly, obtains antibacterial powder.
Lavipeditum medicine vinegar product manufactured in the present embodiment through disease prevention and control center of Hunan Province according to《Disinfection technology standard》
The regulation of (version in 2002) carries out stimulate the reaction scoring and stimulus intensity evaluation, belongs to nonirritant.
Embodiment 5：Cure rate contrast test
Selection moistening erosive and the most common and more serious tinea pedis patient of 2 kinds of scales of skin that peel off keratinization type, grouping are treated, point
Not Shi Yong the embodiment of the present invention 1 prepare product (hereinafter referred to as sample 1), existing patent CN102429990 embodiments 1 prepare
Product (hereinafter referred to as sample 2), with equivalent drug, identical course of therapy, to compare cure rate, the effective percentage of two kinds of technical solutions.
Case enters a group symptom：It is apparent to moisten erosive type-local inflammation, dipping is rotten to the corn, there is apparent exudation, feels pain of itching, foot
Smelly, summer is common, mostly secondary to type between toe or pompholyx type；Scales of skin that peel off keratinization type-heel, sufficient side and sole have limitation irregular
Scaling patch, surface angling is apparent, and coarse drying, winter easily chaps, and summer may occur in which papule or phlycten, and itch is apparent, disease
Journey is chronic.
Curative effect judging standard：Recovery from illness standard is to itch to completely disappear bitterly, and basic healing, no scurf fall off at erosion, fungi inspection
Feminine gender is surveyed, follow-up is without recurrence after January；Effective standard is to itch bitterly without apparent, and healing no less than 50%, still there is a small amount of skin at erosion
Skin furfur, fungal detection are negative；Null criterion is still to have pain of itching after being discontinued, and heal unobvious at erosion, and scurf is without improvement, fungi
Detection is positive.
Patient's basic condition：It collects in 64 cases, fungal detection and culture are the positive.Man 39, female 25；Age
It is 58 years old maximum, it is 15 years old minimum；Course of disease longest 7 years, it is most 3 weeks short, it is 5 months average.Occupation includes work, agriculture, quotient, teacher, white collar etc..
It is randomly divided into 2 groups.
Therapy：
Sample 1：30 grams of antibacterial powder is taken, is set in foot washing basin, 700 milliliters of boiling water is added, about after five minutes medicine vinegar liquid is added in stirring
100 milliliters, both feet are impregnated 30 minutes while hot, are cleaned after.1 time a day.Treatment moistening erosive type is used continuously 2 times,
Scales of skin that peel off keratinization type is treated to be used continuously 5 times.Checking on effect after 10 days.
Sample 2：100 milliliters of bubble foot vinegar liquid is taken, 700 milliliters of water is heated, both feet are impregnated 30 minutes while hot, are cleaned i.e. after
It can.1 time a day.Treatment moistening erosive type is used continuously 2 times, and treatment scales of skin that peel off keratinization type is used continuously 5 times.Effect is checked after 10 days
Fruit.
As a result it and analyzes：
The effect of 1 two kinds of kind treatment moistening erosive beriberis of table, compares
| Kind | It cures | Effectively | In vain | Total effective rate |
| Sample 1 | 9 | 6 | 1 | 93.75% |
| Sample 2 | 3 | 8 | 5 | 68.75% |
The effect of 2 two kinds of kind treatment scales of skin that peel off keratinization type tinea pedis of table, compares
| Kind | It cures | Effectively | In vain | Total effective rate |
| Sample 1 | 7 | 7 | 2 | 87.50% |
| Sample 2 | 4 | 6 | 6 | 62.50% |
The comprehensive therapeutic effect comparison of 3 two kinds of kind treatment tinea pedis of table
| Kind | It cures | Effectively | In vain | Total effective rate |
| Medicine vinegar of the present invention | 16 | 13 | 3 | 90.63% |
| Have patent and steeps foot vinegar | 7 | 14 | 11 | 65.63% |
From table 1- tables 3：The lavipeditum medicine vinegar treatment tinea pedis total effective rate prepared by the present invention is 90.63%, hence it is evident that high
In patent CN102429990 bubble foot vinegar total effective rate 65.63%, statistical analysis shows P ＜ 0.05, illustrates lavipeditum medicine vinegar of the present invention
For the bubble foot vinegar of existing patent, curative effect is more preferably.To also indicate that, product of the present invention works compared with existing product
Faster.
It is tested using 4 product of embodiment 2- embodiments according to this embodiment method, the results show that foot of the present invention
Bathe medicine vinegar product after 10 days total cure rate reach 90%, hence it is evident that be higher than sample 2.
Embodiment 6：Different solution extraction experiment
Solvent proportioning is the key that Soakage extraction, and the present embodiment has selected 6 kinds of Different solutions (being specifically shown in Table 4) to be carried with water
Technique is compared, and wherein double solvent proportioning is calculated by the volume of 95% ethyl alcohol, acetic acid, water, used Cortex Phellodendri, hardship
4 kinds of ginseng, corter pseudolaricis, Chinese prickly ash Chinese medicine sources, weight are consistent.
4 normal temperature dipping of table extracts experimental condition
According to the experimental condition of above-mentioned determination, normal temperature dipping extraction is carried out respectively to the solvent and water of 6 kinds of different ratios, and
Content detection is carried out to the characteristic biological alkali of this 7 kinds of extracting solutions respectively, as a result see the table below：
Extracting solution alkaloid content determination result obtained by 5 different ratio solvent of table
Double solvent entirety alkaloid highest as shown in Table 5, pure 95% ethyl alcohol gained content is moderate, is purely with water
Content is minimum therefore best with the extraction effect of double solvent obtained by solvent.Wherein in the different ratio of double solvent, with this hair
Bright proportioning 5:3:2 highests.
Embodiment 7：The Contrast on effect of complete water boiling method extraction process and complete double solvent soaking technology
In order to which preparation process more provided by the invention and patent CN102429990 steep the preparation process quality of foot vinegar, this
Experimental design chooses No. 1, No. 2, No. 6 solvents proportioning in 6 table 5 of embodiment, according to the embodiment of the present invention 1 medicine vinegar liquid formula and
Preparation method makes complete medicine vinegar liquid, and number is 1,2,3 respectively；By the medicine vinegar liquid formula of the embodiment of the present invention 1 according to
The water boiling and extraction method that CN102429990 bubble foot vinegar embodiment 1 is recorded makes complete medicine vinegar liquid, number 4.4 kinds of samples of gained
Product are placed in subzero 2 degree of environment and place 24 hours, then carry out content detection to alkaloid respectively, and observe clarity, gained
It the results are shown in Table 6.
6 finished product detection result of table
As shown in Table 6, proportioning acquired results defined by the present invention are best, and ethanol results are moderate, water boiling and extraction result
Than worst, and product stability is relatively low.
The explanation of above example is only intended to facilitate the understanding of the method and its core concept of the invention.It should be pointed out that pair
For those skilled in the art, without departing from the principle of the present invention, the present invention can also be carried out
Some improvements and modifications, these improvement and modification are also fallen within the protection scope of the claims of the present invention.
Claims (5)
1. a kind of lavipeditum medicine vinegar for treating tinea pedis, which is characterized in that be made of medicine vinegar liquid and antibacterial powder, every liter of medicine vinegar liquid by
Following raw material is made：
20 portions of Cortex Phellodendris, 15 parts of kuh-sengs, 20 parts of corter pseudolaricis, 5 portions of Chinese prickly ashes, 500 part of 95% ethyl alcohol, 240 parts of acetic acid, 160 parts of water, 2 parts
Menthol, 20 parts of benzoic acid, 50 parts of glycerine, 75% ethyl alcohol of surplus complement to 1L；
Alternatively, 10 portions of Cortex Phellodendris, 10 parts of kuh-sengs, 10 parts of corter pseudolaricis, 1 portion of Chinese prickly ash, 450 part of 95% ethyl alcohol, 180 parts of acetic acid, 120 parts
Water, 1 part of menthol, 10 parts of benzoic acid, 80 parts of glycerine, 75% ethyl alcohol of surplus complement to 1L；
Alternatively, 30 portions of Cortex Phellodendris, 30 parts of kuh-sengs, 30 parts of corter pseudolaricis, 10 portions of Chinese prickly ashes, 550 part of 95% ethyl alcohol, 300 parts of acetic acid, 200 parts
Water, 5 parts of menthols, 30 parts of benzoic acid, 10 parts of glycerine, 75% ethyl alcohol of surplus complement to 1L；
Alternatively, 25 portions of Cortex Phellodendris, 25 parts of kuh-sengs, 25 parts of corter pseudolaricis, 7 portions of Chinese prickly ashes, 550 part of 95% ethyl alcohol, 270 parts of acetic acid, 180 parts
Water, 4 parts of menthols, 25 parts of benzoic acid, 40 parts of glycerine, 75% ethyl alcohol of surplus complement to 1L；
Each raw material of antibacterial powder is in parts by weight：
300 parts of alum, 200 parts of boric acid, 200 parts of smilax, 150 parts of salt, 150 parts of talcum powder；
Alternatively, 200 parts of alum, 150 parts of boric acid, 150 parts of smilax, 100 parts of salt, 400 parts of talcum powder；
Alternatively, 100 parts of alum, 100 parts of boric acid, 100 parts of smilax, 300 parts of salt, 100 parts of talcum powder；
Alternatively, 400 parts of alum, 300 parts of boric acid, 300 parts of smilax, 200 parts of salt, 300 parts of talcum powder.
2. lavipeditum medicine vinegar according to claim 1, which is characterized in that the volume mass ratio of the medicine vinegar liquid and antibacterial powder is
100mL:20-30g。
3. a kind of preparation method of lavipeditum medicine vinegar that treating tinea pedis, which is characterized in that including：
4 kinds of Cortex Phellodendri, kuh-seng, corter pseudolaricis, Chinese prickly ash pulverizing medicinal materials are taken, solvent is added and impregnates 2 times, the solvent is 95% ethyl alcohol, vinegar
The mixed solvent of acid and water composition, merges 2 filtrates, obtains extracting solution；Benzoic acid, menthol are dissolved in remaining 95% ethyl alcohol
In, glycerine mixing is added, is then added in said extracted liquid, stirs evenly, is settled to 1L with 75% ethyl alcohol, mixing is equal
It is even, obtain medicine vinegar liquid；
Alum, boric acid, smilax, salt, talcum powder are respectively crushed into fine powder, 60 mesh sieve is crossed, is then mixed evenly, obtains
Obtain antibacterial powder；
The medicine vinegar liquid and antibacterial powder form lavipeditum medicine vinegar, and every liter of medicine vinegar liquid is made of following raw material：
20 portions of Cortex Phellodendris, 15 parts of kuh-sengs, 20 parts of corter pseudolaricis, 5 portions of Chinese prickly ashes, 500 part of 95% ethyl alcohol, 240 parts of acetic acid, 160 parts of water, 2 parts
Menthol, 20 parts of benzoic acid, 50 parts of glycerine, 75% ethyl alcohol of surplus complement to 1L；
Alternatively, 10 portions of Cortex Phellodendris, 10 parts of kuh-sengs, 10 parts of corter pseudolaricis, 1 portion of Chinese prickly ash, 450 part of 95% ethyl alcohol, 180 parts of acetic acid, 120 parts
Water, 1 part of menthol, 10 parts of benzoic acid, 80 parts of glycerine, 75% ethyl alcohol of surplus complement to 1L；
Alternatively, 30 portions of Cortex Phellodendris, 30 parts of kuh-sengs, 30 parts of corter pseudolaricis, 10 portions of Chinese prickly ashes, 550 part of 95% ethyl alcohol, 300 parts of acetic acid, 200 parts
Water, 5 parts of menthols, 30 parts of benzoic acid, 10 parts of glycerine, 75% ethyl alcohol of surplus complement to 1L；
Alternatively, 25 portions of Cortex Phellodendris, 25 parts of kuh-sengs, 25 parts of corter pseudolaricis, 7 portions of Chinese prickly ashes, 550 part of 95% ethyl alcohol, 270 parts of acetic acid, 180 parts
Water, 4 parts of menthols, 25 parts of benzoic acid, 40 parts of glycerine, 75% ethyl alcohol of surplus complement to 1L；
Each raw material of antibacterial powder is in parts by weight：
300 parts of alum, 200 parts of boric acid, 200 parts of smilax, 150 parts of salt, 150 parts of talcum powder；
Alternatively, 200 parts of alum, 150 parts of boric acid, 150 parts of smilax, 100 parts of salt, 400 parts of talcum powder；
Alternatively, 100 parts of alum, 100 parts of boric acid, 100 parts of smilax, 300 parts of salt, 100 parts of talcum powder；
Alternatively, 400 parts of alum, 300 parts of boric acid, 300 parts of smilax, 200 parts of salt, 300 parts of talcum powder.
4. preparation method according to claim 3, which is characterized in that 95% ethyl alcohol in the mixed solvent, acetic acid and water
Volume ratio is 5:3:2.
5. according to preparation method described in claim 3-4 any one, which is characterized in that the volume of the medicine vinegar liquid and antibacterial powder
Mass ratio is 100mL:20-30g.
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| CN106552062A (en) * | 2015-09-29 | 2017-04-05 | 潘永宏 | A kind for the treatment of beri-beri agent |
| CN107158098A (en) * | 2017-06-28 | 2017-09-15 | 湖南七纬科技有限公司 | It is a kind of to be capable of footbath with traditional Chinese medicines vinegar of strengthening the muscles and bones and preparation method thereof |
| CN107596225A (en) * | 2017-10-10 | 2018-01-19 | 袁子钧 | A kind of tinea pedis soak and preparation method |
| CN110884731A (en) * | 2019-09-27 | 2020-03-17 | 四川奥骞科技有限公司 | Formula and preparation process of aromatic vinegar foot bath liquid |
| CN110946896A (en) * | 2019-12-21 | 2020-04-03 | 郑远元 | Formula of traditional Chinese medicine bacteriostatic cream for feet and preparation method thereof |
| CN111265578A (en) * | 2020-03-19 | 2020-06-12 | 坤承(北京)健康管理有限公司 | Antibacterial spray for treating beriberi and preparation method thereof |
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