CN108721451A

CN108721451A - A kind of foot refreshing powder of the prevention tinea pedis foot odour pin sweat containing Bee Pollen

Info

Publication number: CN108721451A
Application number: CN201710248115.6A
Authority: CN
Inventors: 李旭涛; 李文钊; 李文琛
Original assignee: Tianshui Huifeng Bee Industry Science & Technology Co Ltd
Current assignee: Tianshui Huifeng Bee Industry Science & Technology Co Ltd
Priority date: 2017-04-17
Filing date: 2017-04-17
Publication date: 2018-11-02

Abstract

The foot refreshing powder for the prevention tinea pedis foot odour pin sweat containing Bee Pollen that the present invention provides a kind of is the externally-used embrocation or bubble foot preparation that powdery is made of drug ingedients co-grindings such as the rape pollen with abundant nutrition substance, corn poppy's pollen, Pollen Codonopsis, pollen of Semen Fagopyri Esculenti and the propolis extract powders of honeybee acquisition.Drug used in the present invention contain the ingredients such as vitamin, trace element, organic acid, enzyme and Bee Pollen share can effectively solve tinea pedis mechanism it is unknown when prevention situation, one side nutrition body promotes organism balance to adjust, on the one hand collaboration inhibits a variety of Grain-positives and negative bacterium, fungi, trichophyta, toe tinea fungus etc., show heat-clearing and damp-drying drug, sterilizing and itch-relieving, deodorization get rid of illness, relaxing tendons and activating collaterals, strengthening the muscles and bones and other effects, there is unique curative effect to treating and preventing the symptoms such as tinea pedis, foot odour, pin sweat, foot rheumatalgia, and without side-effects.

Description

A kind of foot refreshing powder of the prevention tinea pedis foot odour pin sweat containing Bee Pollen

Technical field

The invention belongs to the field of Chinese medicines, the foot refreshing powder of specifically a kind of prevention tinea pedis foot odour pin sweat containing Bee Pollen.

Background technology

Tinea pedis, motherland's medicine are known as " smelly river snail ", " tinea pedis ", " tinea pedes ", " tinea pedis wet sore ", " weak foot due to dampness ", " toes seam Rotten sore ", " rotten sore ", " pruritus foot sore ", " rotten foot wind ", " foot hemorrhoid ".Such as《Yizong Jinjian surgery heart method》:" this card is wet by stomach Heat bet and give birth to, foot bifurcation is tattered, though suffering from small, strandings of itching cannot solve, must rub with the hands it is rotten to skin, Tianjin smell as of rotten fish water feel pain when, the side of itching Only, next day still itches, and is not cured year in year out, extremely touching.Though " disease be happened at hand, foot part, often have itch pain, sometimes because scratching It grabs and secondary pyogenic infection, or causes lymph node, angioleucitis and erysipelas, septicemia etc., have one to work, health Fixing is rung, it is necessary to be paid attention to.Tinea pedis is the popular name of tinea pedis.Somebody lumps " tinea pedis " and " athlete's foot " together, this is not To." athlete's foot " medically is the systemic disease caused by Vitamin B deficiency, and " tinea pedis " (is also known as by fungi Toadstool) a kind of caused common skin diseases of infection.Foot basin and the towel that wipes one's feet should respectively use in order to avoid infecting other people.Tinea pedis is such as Be not treated in time, sometimes can other positions, such as cause the tinea manuum and onychomycosis, scratched sometimes because itching, secondary bacterial infection, meeting Cause serious complication.Chinese medicine tinea pedis is referred to as " flaccidity of lower limbs ".《Essential Recipes for Emergent Use Worth A Thousand Gold》Roll up 22《Pathogenic wind-toxic beriberi side》：" so this Disease hair, it is first first from foot, because i.e. shin is swollen, when people number be tinea pedis.Deep Shi Yun：Foot weak person, i.e. its justice ".

Tinea pedis is a kind of extremely common fungal infection dermatoses.The people of 70-80% has tinea pedis in adult, and only weight is not With.It is often aggravated in summer, winter mitigates, and also someone is not cured throughout the year.Medically usually by three types of tinea pedis point：Erosive type, water Blister type, keratinization type tinea pedis.

Foot odour is to be easy to perspire since arch of the foot sweat gland, in sweat exceptionally except moisture content, salt, also contains lactic acid and urea. Under the conditions of hidrosis, bacterium mass propagation on foot simultaneously decomposes keratoprotein, along with urea, the lactic acid in sweat, thus A kind of stink can be sent out.If shoes are airtight, the more long-pending atmosphere draught-free, stink will be the denseer, and foul smell is extremely strong.

Clinical treatment there is no specific medicament at present.Clinical treatment mostly be using skin surface smear anti-inflammatory, sterilization, Antipruritic ointment, therapeutic effect is not highly desirable, is still the unsolved problem of medical field at present.

Invention content

Technical problem to be solved by the present invention lies in provide a kind of feeling well for prevention tinea pedis foot odour pin sweat containing Bee Pollen Foot-powder is using the rape pollen with abundant nutrition substance of honeybee acquisition, corn poppy's pollen, Pollen Codonopsis, pollen of Semen Fagopyri Esculenti The externally-used embrocation or bubble foot preparation of powdery are made with drug ingedients co-grindings (particle is less than 0.14 millimeter) such as propolis extract powders. Drug used in the present invention, which contains the ingredients such as vitamin, trace element, organic acid, enzyme, and Bee Pollen shares can effectively solve foot Prevention situation when mechanism of qi manages unknown, one side nutrition body promote organism balance to adjust, and on the one hand collaboration inhibits a variety of leather blue Positive and negative bacterium, fungi, trichophyta, toe tinea fungus etc., show that heat-clearing and damp-drying drug, sterilizing and itch-relieving, deodorization gets rid of illness, relaxing muscles and tendons is lived Blood, strengthening the muscles and bones and other effects have unique curative effect, and nothing to treating and preventing the symptoms such as tinea pedis, foot odour, pin sweat, foot rheumatalgia Side effect.Plurality of active ingredients in product intactly remains behind, and so that epidermal tissue is easy rapid absorption, no matter smears Or adds bubble foot, all have the advantages that cure rate is high, the duration is long.

A kind of foot refreshing powder of the prevention tinea pedis foot odour pin sweat containing Bee Pollen, it is characterised in that：It is by following raw material Composition：

200-300 parts of rape pollen, 100-300 parts of corn poppy's pollen, Pollen Codonopsis 100-200 parts, pollen of Semen Fagopyri Esculenti 100- 200 parts, 10-20 parts of propolis extract powder, 10-20 parts of ketoconazole powder, 10-30 parts of kuh-seng, 10-30 parts of azedarach, 6-20 parts of schizonepeta, 20-40 parts of the coptis, 10-30 parts of radix scutellariae, 10-30 parts of Cortex Phellodendri, 30-50 parts of cape jasmine, 6-10 parts of rhizoma atractylodis, 10-30 parts of peppermint, grass-leaved sweetflag 10-30 parts, 10-30 parts of Tarragon, 6-15 parts of indigo naturalis, 20-40 parts of frutus cnidii, 30-50 parts of Chinese prickly ash, 40-80 parts of alumen, gypsum 25-50 parts.

Preparation method：

Step 1：By formula rate by kuh-seng, azedarach, schizonepeta, the coptis, radix scutellariae, Cortex Phellodendri, cape jasmine, rhizoma atractylodis, peppermint, stone Chang Pu, Tarragon, frutus cnidii, that Chinese prickly ash drying is made 300-400 mesh fine powders is spare, and alumen, gypsum, indigo naturalis are ground to 300-400 Mesh fine powder is spare；

Step 2：The residual drug addition spare fine powder of step 1 is uniformly mixed by formula rate, Cord blood is up to this hair Bright foot refreshing powder.

Impregnating the when of using first is added to the water drug and stirs evenly, and then impregnates both feet, every time about half an hour, carries out daily Twice, then wiped clean gauze wrapped is good.Five doses are made as a treatment course, and about three courses for the treatment of or so can fully recover.

250 parts of rape pollen, 200 parts of corn poppy's pollen, 150 parts of Pollen Codonopsis, 150 parts of pollen of Semen Fagopyri Esculenti, propolis extract powder 15 parts, 15 parts of ketoconazole powder, 20 parts of kuh-seng, 20 parts of azedarach, 15 parts of schizonepeta, 30 parts of the coptis, 20 parts of radix scutellariae, 20 parts of Cortex Phellodendri, Cape jasmine It is 40 parts of son, 8 parts of rhizoma atractylodis, 20 parts of peppermint, 20 parts of grass-leaved sweetflag, 20 parts of Tarragon, 10 parts of indigo naturalis, 30 parts of frutus cnidii, 40 parts of Chinese prickly ash, withered 60 parts of alum, 30 parts of gypsum.

Specific implementation mode：

Embodiment 1, formula：200 parts of rape pollen, 100 parts of corn poppy's pollen, 100 parts of Pollen Codonopsis, pollen of Semen Fagopyri Esculenti 100 Part, 10 parts of propolis extract powder, 10 parts of ketoconazole powder, 10 parts of kuh-seng, 10 parts of azedarach, 6 parts of schizonepeta, 20 parts of the coptis, 10 parts of radix scutellariae, 10 parts of Cortex Phellodendri, 30 parts of cape jasmine, 6 parts of rhizoma atractylodis, 10 parts of peppermint, 10 parts of grass-leaved sweetflag, 10 parts of Tarragon, 6 parts of indigo naturalis, 20 parts of frutus cnidii, 30 parts of Chinese prickly ash, 40 parts of alumen, 25 parts of gypsum.

Preparation method：

Embodiment 2, formula：250 parts of rape pollen, 200 parts of corn poppy's pollen, 150 parts of Pollen Codonopsis, pollen of Semen Fagopyri Esculenti 150 Part, 15 parts of propolis extract powder, 15 parts of ketoconazole powder, 20 parts of kuh-seng, 20 parts of azedarach, 15 parts of schizonepeta, 30 parts of the coptis, radix scutellariae 20 Part, 20 parts of Cortex Phellodendri, 40 parts of cape jasmine, 8 parts of rhizoma atractylodis, 20 parts of peppermint, 20 parts of grass-leaved sweetflag, 20 parts of Tarragon, 10 parts of indigo naturalis, frutus cnidii 30 Part, 40 parts of Chinese prickly ash, 60 parts of alumen, 30 parts of gypsum.

Preparation method is same as Example 1.

Embodiment 3, formula：300 parts of rape pollen, 300 parts of corn poppy's pollen, 200 parts of Pollen Codonopsis, pollen of Semen Fagopyri Esculenti 200 Part, 20 parts of propolis extract powder, 20 parts of ketoconazole powder, 30 parts of kuh-seng, 30 parts of azedarach, 20 parts of schizonepeta, 40 parts of the coptis, radix scutellariae 30 Part, 30 parts of Cortex Phellodendri, 50 parts of cape jasmine, 10 parts of rhizoma atractylodis, 30 parts of peppermint, 30 parts of grass-leaved sweetflag, 30 parts of Tarragon, 15 parts of indigo naturalis, frutus cnidii 40 parts, 50 parts of Chinese prickly ash, 80 parts of alumen, 50 parts of gypsum.

Preparation method is same as Example 1.

Pharmacology pharmacodynamic is tested：

Animal local stimulation is tested：

Allergic reaction on guinea pigs and Rat-rectum medication irritation test of the present invention.The result shows that：Skin anaphylactic test, High dose group 0.8g (medicinal powder)/kg, low dose group 0.1g (medicinal powder)/kg are respectively equivalent to quasi- clinical people's dosage [0.04g (medicines Powder)/kg] 20 times, 2.5 times, through percutaneous drug delivery, be showed no animal and generate allergy；The high agent of rectal application irritation test Amount group 5.0g (medicinal powder)/kg, low dose group 3.2g (medicinal powder)/kg are respectively equivalent to 125,80 times of quasi- clinical people's dosage, are advising In fixed time observation mucous membrane of rectum without congested, oedema phenomena such as, histopathologic examination is compared with blank control group without bright Significant difference is different, has no apparent irritative response occur, its overall health of patients of the Some Animals of every group of retention, weight, breathing, cycle, Central nervous system and four limbs activity etc., equal Non Apparent Abnormality reaction.

1 clinical data

Treat tinea pedis observation of curative effect

Tinea pedis is the common disease of dept. of dermatology, we treat tinea pedis in March, 2017 in April, 2015-using self-control foot refreshing powder 500 many cases of case obtain good result, are now summarized as follows.

Typical clinical case inclusion criteria：

Inclusion criteria：With typical clinical manifestation, meet tinea pedis ringworm of the foot diagnostic criteria, does not do any drug in January and control It treats, no merging other diseases.

Rejecting standard：To this product allergy sufferers；Prolonged application corticosteroid hormone person；Symptomatic tinea pedis；Interrupt treatment and It is unable to further consultation person.

Selected case 60 is equally divided into three groups (control group 1, control groups 2, treatment group) wherein 38 women 22 of male Example, minimal ages 18 years old are 63 years old maximum, average age 34 years old, wherein vesicle 31, erosive type 20, keratinization type 9, disease People's illness to consultation time longest more than 3 years, most it is short more than a year.Clinical symptoms：There are the phlysis being dispersed in, rotten to the corn exudation, pain in part Bitterly, swelling, very itch, dysfunction etc..

Administrated method：

Control group 1 dips certain compound tinea pedis tincture with cotton swab, is uniformly applied to affected part, area is slightly larger than skin lesion, early, middle and late Each primary, medication is observed for 10 days.

Control group 2 is smeared using ketoconazole ointment merely, each primary in the morning, afternoon and evening, and medication is observed for 10 days.

Treatment group takes Chinese medicine compound prescription foot refreshing powder of the present invention, is first added to the water drug when impregnating use and stirs evenly, then impregnates Both feet every time about half an hour, carry out twice daily, and then wiped clean gauze wrapped is good, and medication is observed for 10 days.

Efficacy determination：Using 4 grades of standards

Recovery from illness：10 days observation clinical symptoms of medication and sign completely disappear, and local skin is intact.

It is effective：10 days observation clinical symptoms of medication and sign disappear substantially, and local skin is intact.

Effectively：10 days observation clinical symptoms of medication and sign are obviously improved, and local skin damage is substantially reduced.

In vain：10 days observation clinical symptoms of medication and sign are not improved, and local pain, swelling are without substantially reduced.

Treatment results are shown in Table 1-3.

1 three groups for the treatment of results of table (unit example)

Group	n	Recovery from illness	It is effective	Effectively	In vain
						Treatment group	20	19	1	-	-
Control group 1	20	13	2	4	1
						Control group 2	20	10	5	1	4

1 statistical analysis of table prompts：Treatment group's treatment results compared with the control group, the statistically significant (P of difference<0.05).

Symptom recurrence compares (example) after 2 three groups of half a year of table

Group	n	Recurrence	Recovery from illness
				Treatment group	20	-	20
Control group 1	20	9	11
				Control group 2	20	15	5

2 statistical analysis of table prompts：Treatment group's recurrence compared with the control group, the statistically significant (P of difference<0.05).

Drug and common externally applied ointment through the Experimental Comparison more existing preparation of Chinese medicine compound prescription foot refreshing powder of the present invention have significantly Therapeutic effect.

All above-mentioned this intellectual properties of primarily implementation, there is no this new products of implementation of setting limitation other forms And/or new method.Those skilled in the art will utilize this important information, the above modification, to realize similar execution feelings Condition.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above described is only a preferred embodiment of the present invention, being not that the invention has other forms of limitations, appoint What those skilled in the art changed or be modified as possibly also with the technology contents of the disclosure above equivalent variations etc. Imitate embodiment.But it is every without departing from technical solution of the present invention content, according to the technical essence of the invention to above example institute Any simple modification, equivalent variations and the remodeling made, still fall within the protection domain of technical solution of the present invention.

Claims

1. a kind of foot refreshing powder of the prevention tinea pedis foot odour pin sweat containing Bee Pollen, it is characterised in that：It is by following raw material group At：

200-300 parts of rape pollen, 100-300 parts of corn poppy's pollen, Pollen Codonopsis 100-200 parts, pollen of Semen Fagopyri Esculenti 100-200 Part, 10-20 parts of propolis extract powder, 10-20 parts of ketoconazole powder, 10-30 parts of kuh-seng, 10-30 parts of azedarach, 6-20 parts of schizonepeta, Huang 20-40 parts of company, 10-30 parts of radix scutellariae, 10-30 parts of Cortex Phellodendri, 30-50 parts of cape jasmine, 6-10 parts of rhizoma atractylodis, 10-30 parts of peppermint, grass-leaved sweetflag 10-30 parts, 10-30 parts of Tarragon, 6-15 parts of indigo naturalis, 20-40 parts of frutus cnidii, 30-50 parts of Chinese prickly ash, 40-80 parts of alumen, gypsum 25-50 parts；Preparation method：

Step 1：By formula rate by kuh-seng, azedarach, schizonepeta, the coptis, radix scutellariae, Cortex Phellodendri, cape jasmine, rhizoma atractylodis, peppermint, grass-leaved sweetflag, Tarragon, frutus cnidii, that Chinese prickly ash drying is made 300-400 mesh fine powders is spare, and it is thin that alumen, gypsum, indigo naturalis are ground to 300-400 mesh Powder is spare；

Step 2：The residual drug addition spare fine powder of step 1 is uniformly mixed by formula rate, Cord blood is refreshing up to the present invention Foot-powder；

Impregnating the when of using first is added to the water drug and stirs evenly, and then impregnates both feet, every time about half an hour, carries out two daily Secondary, then wiped clean gauze wrapped is good.Five doses are made as a treatment course, and about three courses for the treatment of or so can fully recover.

2. a kind of foot refreshing powder of prevention tinea pedis foot odour pin sweat containing Bee Pollen according to claim 1, it is characterised in that：It is It is composed of the following raw materials by weight：

250 parts of rape pollen, 200 parts of corn poppy's pollen, 150 parts of Pollen Codonopsis, 150 parts of pollen of Semen Fagopyri Esculenti, 15 parts of propolis extract powder, 15 parts of ketoconazole powder, 20 parts of kuh-seng, 20 parts of azedarach, 15 parts of schizonepeta, 30 parts of the coptis, 20 parts of radix scutellariae, 20 parts of Cortex Phellodendri, cape jasmine 40 Part, 8 parts of rhizoma atractylodis, 20 parts of peppermint, 20 parts of grass-leaved sweetflag, 20 parts of Tarragon, 10 parts of indigo naturalis, 30 parts of frutus cnidii, 40 parts of Chinese prickly ash, alumen 60 Part, 30 parts of gypsum.