KR101188216B1 - Natural complex extract Composition for preventing falling out of the hair and promoting growth of the hair containing black soybean paste's active principle - Google Patents

Abstract

The present invention relates to a natural complex extract composition for preventing hair loss and promoting hair growth, comprising the active ingredients of black soybean miso and natto as main ingredients, and more specifically, isoflavone aglycone component genistein and antioxidant effects Black soybean miso and natto that contain large amounts of anthocyanin as active ingredients, black rice rich in anthocyanin in natto, sedatives with soothing action, and polyphenol-based flavonoids and catechins have antibacterial and antioxidant effects By mixing green tea and sewage with anti-aging function in a certain ratio to extract the natural complex extraction composition,
Along with the prevention of hair loss, it is to provide a natural complex extract composition for preventing hair loss and promoting hair growth that can exert an excellent effect on promoting hair growth and antioxidant, antibacterial, strengthening the hair, and soothing the scalp.

Description

Natural complex extract composition for preventing falling out of the hair and promoting growth of the hair containing black soybean paste's active principle}

The present invention relates to a natural complex extract composition for preventing hair loss and promoting hair growth, comprising the active ingredients of black soybean miso and natto as main ingredients.

In recent years, due to severe environmental pollution and the occurrence of various complex diseases that are difficult to determine the cause, hair loss is increasing not only for men, but also for women, the study to identify and improve the cause Has been actively progressing.

In general, hair is a keratin protein that contains a lot of cystine and is composed of 18 kinds of amino acids, melanin pigment, lipids, trace elements, and moisture, and is divided into hair shafts on the surface of the skin and hair roots inside the skin. The inflated part under the hair root is called mogu, and the part that is spherical in the central part of the hair follicle is called breast milk. The outermost layer of the scalp surface is a hard, scaly protective layer, and the middle layer supports the hair. The color and shape of the hair is determined, and the lower layer is known to nourish hair growth.

Hair with this structure is affected by testosterone, a male hormone at puberty, and when puberty is overproduced by dihydrotestosterone (DHT), a byproduct of testosterone, a common male and female hormone. Hair loss is easy to occur.

Hair loss is caused by age, race, season, genetic factors, excessive release of male hormones, seborrheic skin, stress, diet, hair pollution, air pollution, drug use, and various diseases. The degree is known to be related to hereditary and hormonal factors, the symptoms are scalp disease, male hair loss, circular hair loss, resting hair loss, growing hair loss.

Dihydrotestosterone (DHT) is made by both men and women, and this hormone gradually shrinks hair follicles, making the hair thinner and thinner, and eventually hair loss occurs. It is known as testosterone hair loss.

For women, the female hormone estrogen and the antibody hormone progesterone protect hair follicles from the destructive functions of DHT, resulting in relatively fewer hair loss than men, but many women have experienced changes in these hormone levels, Or you may experience gynecomastia, in which the hair grows thinner due to increased levels of DHT production and instability in the levels of female hormones that appear before and after menopause.

Therefore, in order to prevent hair loss caused by such hormone changes, hair loss preventing agents of these hormone systems are commercially available.

These hair loss preventives are effective at the time of administration, but if they are stopped, hair loss resumes, and side effects include sexual dysfunction such as loss of energy, erectile dysfunction, and various restrictions such as prohibition of use during pregnancy. There is this.

Therefore, to improve the shortcomings of the hormonal hair loss inhibitors, studies have been made to develop a substance that inhibits the production and activity of 5-alpha reductase, which is known to promote the production of DHT. It is becoming.

As part of this, an anti-hair loss agent by isoflavones known as phytoestrogens is known from US Pat. No. 6,017,893.

It is known that genistein contained in soybean is an isoflavone aglycone component.

It is not yet commercially available.

The present invention has been studied in view of all the problems that such a conventional hair loss preventing agent,

It is an object of the present invention to provide a natural extract composition for preventing hair loss and promoting hair growth that can exert an excellent effect on hair growth promotion and antioxidant, antibacterial, hair root strengthening, scalp soothing and the like, along with hair loss prevention.

To this end, the present invention is an isoflavone aglycone ingredient zenithine that is effective to prevent hair loss in black soybean miso and natto fermented black soybeans, antioxidant antioxidant for healthy hair care (anthocyanin) contains a large amount as an active ingredient Paying attention to the point

Its main ingredients are black soybean miso and natto, which are rich in anthocyanin-rich black rice, soothing scents, polyphenol-based flavonoids and catechins, and green tea with antibacterial and antioxidant effects. By extracting natural complex extraction composition by mixing sewage with prevention function in a certain ratio,

Along with the prevention of hair loss, it is characterized in that it is possible to provide a natural complex extraction composition for preventing hair loss and promoting hair growth that can exert an excellent effect on promoting hair growth and antioxidant, antibacterial, strengthening the hair, and soothing the scalp.

The natural complex extract composition for preventing hair loss and promoting hair growth is a natural complex extract composition obtained by mixing black rice, soybean paste, green tea, and sewage in a certain ratio in black bean miso and natto containing a large amount of genistein and anthocyanin,

In addition to preventing hair loss, it has an excellent effect on promoting hair growth and anti-oxidation, antibacterial, strengthening the hair root, and soothing the scalp.

Hereinafter, the present invention will be described in detail.

First, black soybean miso and natto, which are the main components of the natural complex extract composition for preventing hair loss and enhancing hair growth according to the present invention, and black rice, centella, green tea, and sewage, which are raw materials of the natural plant complex extract added thereto, It has been found that the main ingredients and efficacy.

1. Black bean miso and natto

(1) gamma polyglutamic acid

-Sticky ingredients of black bean miso and natto

-Natural moisturizer with hyaluronic acid more than 10 times moisturizing

-Hair strengthening effect by surface protection of hair

(2) Zenithin

-Substances good for scalp, such as hair loss prevention

Lowers the level of DHT in the blood

(3) Genistein

-Created during fermentation of miso

-Created by removing sugar from soy-rich Zenithin

-Preventive and anti-inflammatory effects of cancer, heart disease, osteoporosis

-Control skin inflammatory process

-Inhibition of vascular endothelial growth factor (VEGF) and IL-8 secretion

(4) equal

-Molecules in Miso

Inhibits the conversion of testosterone to DHT

(5) lecithin

-Prevent brain dementia by improving brain function

(6) arginine

-High Amino Acids in Black Beans

-Nutrients essential for hair growth

-Nitric Oxide Metabolic Precursor to Promote Hair Growth

(7) cysteine

-High Amino Acids in Black Beans

-Essential ingredient for hair growth

-Hair loss prevention effect

(8) Vitamin E and Unsaturated Fatty Acids

Induction of vasodilation

-Smooth circulation of peripheral blood

-Promotes nutrition to the scalp

(9) anthocyanins

- Antioxidative effect

-Free radical removal

-Anti oxidation

2. Black Rice

-Rich in anthocyanins

-Hair elasticity supply

-Prevents hair from drying

-Damaged Hair Improvement

3. Centella

-Excellent sedation

-Anti-inflammatory effect

-Wound healing effect

-Antibacterial

4. Green Tea

-Rich in polyphenolic flavonoids and catechins

-Antibacterial effect

- Antioxidative effect

5. Sewao

-Anti aging agent for scalp and hair

- Antioxidative effect

In addition, the natural complex extract composition for preventing hair loss and promoting hair growth according to the present invention may further include epidermal growth factor EGF and insulin growth factor IGF-1, which are widely known as components that help hair growth. .

Hereinafter, a preferred embodiment of the natural complex extraction composition for preventing hair loss and promoting hair growth according to the present invention will be described in detail.

Example

1. Raw material mixing

First, each raw material of Table 1 is mixed evenly according to the ratio of each content. Here, either black bean miso and sickle or black bean miso and natto may be mixed alone, or two raw materials may be mixed at any ratio.

Raw material name

Content (weight%)
Black bean miso and natto

40-60
Black rice

10-15
Centella

10-15
green tea

10-15
Shouao

10-15

2. heating

The mixed raw materials are placed in a boiling water still and heated at a temperature of 60 ° C. for 48 hours to obtain a hydrothermal extract.

3. Filtration

The obtained hydrothermal extract is filtered through 250 mesh and 0.5 μm filter paper to obtain a liquid extract.

4. Thickening

The filtered liquid extract was concentrated under reduced pressure at a temperature of 60 ° C. using a rotary pressure reducer to obtain a concentrate of the natural complex extract composition of the present invention.

Referring to the relevant test example for the natural complex extraction composition for preventing hair loss and hair growth promotion according to the present invention thus prepared as follows.

1. Antioxidant efficacy test

(1) test method

A single extract of black bean miso and natto were separately extracted, and the DPPH antioxidant activity of the complex extract extracted by mixing the four natural plants was confirmed.

(2) results

Compared to a single extract of doenjang and natto, the complex extract showed an excellent antioxidant effect, as shown in Table 2.

2. Antimicrobial Activity Test

(1) test method

After pre-cultivation of microorganisms such as bacteria, dandruff and yeast, respectively, in a sterilized flat medium, the natural complex extract according to the present invention is dipped in a sterilized paper disc according to the disk diffusion method at the same concentration, and then the microorganisms are smeared. After raising the plate to the culture medium at an appropriate temperature, the size of the growth zone (Clear zone) was measured.

(2) results

All microorganisms including dandruff were confirmed to have antimicrobial activity as shown in Table 3.

Strain

Unit (mm)
Esherichia coli

  11
Pseudomonas aeruginosa

  13
Staphylococus aureus

  12
Candida albican

  10
Malassezia furfur

  13
Aspergillus niger

  11

3. Hair growth promoting effect test

(1) test method

After completely removing the hair on the back of the 8-week-old C57BL / 6 mouse with a razor blade, the natural complex extract according to the present invention was applied to the shaving area twice daily, and distilled water was applied to the control group. The hair growth state was observed while applying for a total of 3 weeks, and compared with the area where the hair was removed, the rate at which the newborn hair was grown was calculated.

(2) results

As a result of observing the hair growth state for three weeks, it was confirmed that there is an excellent hair growth promoting effect as shown in Table 4.

Hair growth promoting effect (%)

1 week

2 weeks
3 weeks
Control group

10%
22%
38%
Complex extract

25%
56%
84%

4. Skin irritation test

(1) Test Method: Skin irritation experiments were performed using 20 patches on healthy adults and men. A 10% SDS solution was used as a positive control, and 10% SDS and the complex extract were applied to the patch by applying a 1: 1 ratio to the subject's abdomen, and the degree of stimulation was determined after 24 hours. Distilled water was used as a negative control.

Irritancy judgment

3: strong inflammatory response

2: erythema and slight inflammation

1: slight erythema

0: no change

CONCLUSIONS: The mean irritancy index of 10% SDS, which is a positive control, was 2.75, as shown in Table 5. However, when the combined extract was treated with 1: 1, 0.35 showed little irritation.

Irritation index


Average degree
  3

  2
  One
  0
Control group

0
0
2
18
0.1
10% SDS

16
3
One
0
2.75
Complex extract

0
One
5
14
0.35

The composition of the present invention prepared as described above is usually prepared in the form of shampoo or rinse (treatment), hair tonic, hair gel, hair lotion, soap, hair pack and the like as shown in Table 6-8.

1. Shampoo

number

Raw material name
Content (% by weight)
One

Complex extract
5.00
2

30% Sodium Lauryl Sulfate
20.00
3

30% Sodium Polyoxyethylene Lauryl Sulfate
20.00
4

Palm oil fatty acid diethanolamide
2.00
5

Propylene glycol
2.00
6

Cocamidopropyl Betaine
3.00
7

Carboxy Vinyl Polymer
0.30
8

Polyquaternium-10
0.50
9

Paraoxybenzoic acid ester
0.20
10

Citric acid
Suitable amount
11

Spices
Suitable amount
12

Purified water
Balance

2. Hair Tonic

number

Raw material name
Content (% by weight)
One

Mixed extract
5.00
2

ethanol
50.00
3

L-menthol
0.10
4

D-panthenol
0.20
5

glycerin
3.00
6

Salicylic acid
0.10
7

Tocopheryl acetate
0.10
8

Polyoxyethylene Cured Castor Oil
0.50
9

Spices
Suitable amount
10

Purified water
Balance

3. Rinse (treatment)

number

Raw material name
Content (% by weight)
One

Mixed extract
5.00
2

Propylene glycol
2.00
3

glycerin
2.00
4

Cetyltrimethylammonium chloride
1.00
5

Cetyl alcohol
3.00
6

Stearyl alcohol
3.00
7

Cyclomethicone
0.40
8

Mineral oil
0.50
9

Citric acid
0.20
10

Polydimethylsiloxane
1.00
11

Spices
Suitable amount
12

Purified water
Balance

Claims (2)

Gamma polyglutamic acid extracted from black soybean miso and natto and natural plant complex extract of Genistein, Genistein, Equal, Lecithin, Arginine, Cysteine, Vitamin E and unsaturated fatty acid, Anthocyanin 40%, Black rice, Centella, Green tea, Sewage A natural complex extract composition for preventing hair loss and promoting hair growth, comprising 40-60% by weight of active ingredients of black soybean miso and natto as main ingredients. delete