CN113101245A - Composition and care product with effect of repairing stretch marks - Google Patents
Composition and care product with effect of repairing stretch marks Download PDFInfo
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- CN113101245A CN113101245A CN202110363218.3A CN202110363218A CN113101245A CN 113101245 A CN113101245 A CN 113101245A CN 202110363218 A CN202110363218 A CN 202110363218A CN 113101245 A CN113101245 A CN 113101245A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/591—Mixtures of compounds not provided for by any of the codes A61K2800/592 - A61K2800/596
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Abstract
The invention belongs to the field of daily chemicals, and discloses a composition with the effect of repairing striae gravidarum, which comprises the following components: olibanum extract, ascorbyl tetraisopalmitate, tocopherol acetate, jojoba oil; the weight ratio of the frankincense extract, the ascorbyl tetraisopalmitate, the tocopherol acetate and the jojoba oil is as follows: 0.5:1-5:5-10: 84.5-93.5. The composition is applied to cream/essential oil skin care products, can effectively lighten striae gravidarum, and is suitable for long-term use by pregnant and delivery periods and common consumers.
Description
Technical Field
The invention relates to the field of daily chemicals, in particular to a composition and a nursing product with the effect of repairing striae gravidarum.
Background
Striae Gravidarum (SG) is one of the most common connective tissue changes during pregnancy, and about 55% to 90% of pregnant and parturient women suffer from Striae gravidarum. Early stretch marks often appear as flat, pink or red stripes that gradually bulge out of the surface of the skin, turning into longer, wider purplish-red stripes (red or immature stripes). Over a period of months to years, the skin lesions gradually shrink with hypopigmentation and depigmentation, forming scar-like atrophy lines (white lines or mature lines) parallel to the line of skin tension. The skin damage is caused to breasts, abdomens, buttocks and thighs, and sometimes has subjective symptoms such as pruritus, burning pain and the like. Although the stretch marks do not threaten the physical health of patients, the stretch marks can cause psychological diseases because the stretch marks affect the beautiful appearance of the skin. Some postpartum women often feel self-inferior due to the fact that the postpartum women cannot treat the stretch marks, are dare to wear the sexy swimwear or soak hot springs in summer, dare to wear the ultra-short skirt and the shorts, and worry about that the spouse is suspect and loses confidence. Some women can not endure severe pruritus and burning sensation to scramble and scratch, and then local infection occurs, and then the skin ointment containing hormone components is used for treatment, so that the effect is not ideal. Many methods for removing striae gravidarum are used, but the effect is not ideal, so that the pregnant women feel stranded and have a temptation, and partial postpartum women have severe depression and the life quality is greatly reduced.
The research finds out that the pathogenesis of striae gravidarum is possible: the skin tension increases and the dermal collagen fiber bundles are severely damaged; abnormal remodeling of the elastic web; abnormal fibroblast metabolism; fibroblast aberration increases collagenase-2 secretion, thereby promoting collagen type I solubilization; reducing estrogen receptor expression to lower estrogen levels can result in some skin changes; androgens such as endogenous testosterone inhibit skin wound healing and exacerbate the inflammatory response. Until now, the pathogenesis, high-risk factors and exact treatment means of the disease are still in the exploration stage.
The more effective striae gravidarum repair products appearing on the market are medicines of retinoids: such as tazarotene, apadaline, etc. However, the application of these drugs may cause skin irritation symptoms such as burning, erythema and desquamation, which may make skin lesions more noticeable. Retinoid drugs are not available for all patients, but are contraindicated in women within the first 3 months of pregnancy or patients with acute or subacute dermatitis, eczematous dermatoses, etc.
The earlier striae gravidarum is treated, the better the recovery. Consumers during pregnancy avoid adverse effects on fetal development of the products and choose the products very carefully. Many reports claim that ingredients such as salicylic acid, salicylic acid derivatives, vitamin a derivatives, etc. are prohibited during pregnancy. Based on this, consumers can only select a repair product without such ingredients.
Olibanum is a hard gel resin exuded from the cut of the trunk of Boswellia carterii belonging to the family Burseraceae. In China, the history of the use of frankincense is long, the frankincense can be seen in famous medical records for the first time, and the frankincense is listed as the top grade, has the effects of activating blood and promoting qi, stimulating the menstrual flow to relieve pain, and reducing swelling and promoting granulation, and is commonly used for treating traumatic injury, rheumatism and rheumatoid arthritis. In traditional indian medicine, mastic formulations are commonly used to treat a variety of inflammatory diseases. Clinical tests and a large number of animal experiments prove that the frankincense extract and various monomer components have remarkable anti-inflammatory effects. The effect of boswellia serrata extract on rat schwann cell proliferation and related protein expression was studied by continental phone et al, northeast university of agriculture. Korean and others discuss the repairing effect of the frankincense extract on peripheral nerve injury through the influence of the frankincense extract on the repair of the peripheral nerve injury in a rat skin defect model, and test results show that the wound healing rate shows that compared with a control group, the wound of a test group can heal faster, and the wound of the test group basically heals at day 14.
In view of the above current situation, many patents for striae gravidarum care products containing boswellia extracts appear. Through researches, the penmen find that the patent can play a role in lightening stretch marks, but has a larger application problem. It has been reported that when the concentration of the boswellia extract is relatively high, significant toxic and side effects occur. The human body mildness test shows that the sensitization of the frankincense extract is greatly improved after the concentration of the frankincense extract exceeds a certain concentration. The use amount of the boswellia extracts described in these patents is far higher than the safe use amount range studied by penmen. Still, the inventors find that the frankincense extract has strong photosensitivity, and the frankincense can quickly change color and taste and increase the sensitization by simple addition and use.
CN200810056415.5 discloses a compound essential oil for repairing striae gravidarum, which is mainly prepared by mixing frankincense essential oil, rose essential oil, jasmine essential oil, orange flower essential oil, carrot seed essential oil and sweet almond oil according to a certain proportion; the essential oil of frankincense is used, and the approximate dosage is 5 per mill to 3.4 percent.
CN201711279677.3 discloses a striae gravidarum repair paste containing epidermal stem cell extract, which comprises rhubarb, natural indigo, frankincense, angelica, ligusticum wallichii, ampelopsis japonica, coptis chinensis, codonopsis pilosula, epidermal stem cell extract and palmitoyl oligopeptide, wherein the content of the frankincense is about 15%.
None of the above protocols addresses the problem of sensitization.
Ascorbyl tetraisopalmitate, also known as tetrahexyldecyl ascorbate, has many functions as a cosmetic ingredient, including skin lightening, promotion of collagen synthesis, and inhibition of lipid peroxidation. As a derivative of vitamin C, tetrahexyldecyl ascorbate is stable at high temperature and has good solubility in oil. Tetrahexyldecyl ascorbate has excellent skin absorbability, and can be decomposed into free vitamin C in skin to realize physiological function.
Tocopheryl acetate, also known as tocopheryl acetate, is an organic substance with a chemical formula of C31H52O3, and is a pale yellow viscous liquid. Is easily soluble in chloroform, diethyl ether, acetone and vegetable oil, soluble in alcohol, and insoluble in water. Has good heat resistance, can be oxidized when being exposed to light, has dark color, belongs to vitamin E derivatives, and has good antioxidant activity.
Jojoba oil is a good moisturizing and moisturizing oil, can maintain skin moisture, prevent wrinkles and soften skin, is suitable for mature and aged skin, and is commonly used for face and body massage and hair care. A large number of safety and toxicological tests prove that the jojoba oil is very safe to be used as cosmetics, does not produce acnes and antigens, and is suitable for various skins.
The application research hopes that the pregnancy striae fading effect of the frankincense extract can be achieved, the allergenicity of the frankincense extract under the same dosage can be remarkably reduced, and the application level of the frankincense extract in the field of cosmetics is improved.
Disclosure of Invention
The invention aims to provide a composition and a care product with the effect of repairing stretch marks. The composition mainly comprises the following raw materials: olibanum extract, ascorbyl tetraisopalmitate, tocopherol acetate, and jojoba oil. The composition is applied to cream/essential oil skin care products, can effectively lighten striae gravidarum, and is suitable for long-term use by pregnant and delivery periods and common consumers.
Unless otherwise specified, the percentages and parts in the present invention are in weight percent.
The specific scheme is as follows: a composition with the effect of repairing stretch marks comprises the following components: olibanum extract, ascorbyl tetraisopalmitate, tocopherol acetate, jojoba oil;
the weight ratio of the frankincense extract, the ascorbyl tetraisopalmitate, the tocopherol acetate and the jojoba oil is as follows: 0.5:1-5:5-10: 84.5-93.5.
In the composition with the effect of repairing stretch marks, the weight ratio of the frankincense extract, the ascorbyl tetraisopalmitate, the tocopherol acetate and the jojoba oil is as follows: 0.5: 1: 5: 93.5.
in the composition with the effect of repairing stretch marks, the weight ratio of the frankincense extract, the ascorbyl tetraisopalmitate, the tocopherol acetate and the jojoba oil is as follows: 0.5: 5: 10: 84.5.
in the composition with the effect of repairing stretch marks, the weight ratio of the frankincense extract, the ascorbyl tetraisopalmitate, the tocopherol acetate and the jojoba oil is as follows: 0.5: 5: 10: 84.5.
in the composition with the effect of repairing stretch marks, the weight ratio of the frankincense extract, the ascorbyl tetraisopalmitate, the tocopherol acetate and the jojoba oil is as follows: 0.5: 3: 8: 88.5.
meanwhile, the invention also discloses a care product with the effect of repairing stretch marks, which contains 1-2 wt% of the composition.
It should be noted that: the efficacy is not obvious when the adding amount is less than 1 percent, and the adding amount is more than 2 percent, so that the risk of allergy is caused.
The invention has the beneficial effects that:
the frankincense extract is easy to deteriorate and taste-changed, but after the frankincense extract is compounded with ascorbyl tetraisopalmitate, tocopherol acetate and jojoba oil, the stability of the composition is greatly improved, and the composition is not easy to deteriorate and taste-changed.
By compounding and optimizing, the product allergy rate can be greatly reduced under the same use concentration of the frankincense extract; under the same usage concentration of the frankincense extract, the striae gravidarum repair effect and the use satisfaction of consumers can be remarkably improved.
Further studies have found that the use of this combination regimen in skin care products is recommended to be no more than 2%, more preferably 1-2%. Above 2% there is a risk of allergy and below 1% the efficacy of the product is not significant.
Detailed Description
The technical solution of the present invention will be described in further detail with reference to the following embodiments, but the present invention is not limited thereto.
In order to more clearly illustrate the present invention, the following examples are given to illustrate the advantages of the present invention.
Description of the raw materials
The boswellia extracts were purchased from robert flavors and fragrances, france;
bio-phenol acetate was purchased from basf (China) Inc.;
ascorbyl tetraisopalmitate was purchased from solar chemical co;
jojoba oil was purchased from henry grease, germany;
olive oil was purchased from henry grease, germany;
macadamia nut oil was purchased from henry oil and fat, germany.
Example 1
Preparation of composition A with effect of repairing striae gravidarum
0.5 part of frankincense extract, 1 part of ascorbyl tetraisopalmitate, 5 parts of tocopherol acetate and 83.5 parts of jojoba oil are respectively and uniformly mixed.
Example 2
Preparation of composition B with effect of repairing striae gravidarum
0.5 part of frankincense extract, 1 part of ascorbyl tetraisopalmitate, 10 parts of tocopherol acetate and 88.5 parts of jojoba oil are respectively and uniformly mixed.
Example 3
Preparation of composition C with effect of repairing striae gravidarum
0.5 part of frankincense extract, 5 parts of ascorbyl tetraisopalmitate, 5 parts of tocopherol acetate and 89.5 parts of jojoba oil are respectively and uniformly mixed.
Example 4
Preparation of composition D with effect of repairing striae gravidarum
0.5 part of frankincense extract, 5 parts of ascorbyl tetraisopalmitate, 10 parts of tocopherol acetate and 84.5 parts of jojoba oil are respectively and uniformly mixed.
Example 5
Preparation of composition E with effect of repairing striae gravidarum
0.5 part of frankincense extract, 3 parts of ascorbyl tetraisopalmitate, 8 parts of tocopherol acetate and 88.5 parts of jojoba oil are respectively and uniformly mixed.
Comparative example 1
Preparation of composition F
Respectively mixing 0.5 parts of Olibanum extract, 5 parts of tocopherol acetate, and 94.5 parts of jojoba oil uniformly.
Comparative example 2
Preparation of composition G
Respectively and uniformly mixing 0.5 part of frankincense extract, 10 parts of tocopherol acetate and 89.5 parts of jojoba oil.
Comparative example 3
Preparation of composition H
0.5 part of frankincense extract, 1 part of ascorbyl tetraisopalmitate and 98.5 parts of jojoba oil are respectively and uniformly mixed.
Comparative example 4
Preparation of composition I
0.5 part of frankincense extract, 5 parts of ascorbyl tetraisopalmitate and 94.5 parts of jojoba oil are respectively and uniformly mixed.
Comparative example 5
Preparation of composition J
0.5 part of frankincense extract, 5 parts of ascorbyl tetraisopalmitate, 10 parts of tocopherol acetate and 84.5 parts of olive oil are respectively and uniformly mixed.
Comparative example 6
Preparation of composition K
0.5 part of frankincense extract, 5 parts of ascorbyl tetraisopalmitate, 10 parts of tocopherol acetate and 84.5 parts of macadamia nut oil are respectively and uniformly mixed.
Comparative example 7
Preparation of composition L
Respectively mixing 0.5 parts of Olibanum extract, 11 parts of tocopherol acetate and 88.5 parts of jojoba oil uniformly.
Comparative example 8
Preparation of composition M
0.5 part of frankincense extract, 11 parts of ascorbyl tetraisopalmitate and 88.5 parts of jojoba oil are respectively and uniformly mixed.
Stability study of compositions A-M
Examination method and results:
placing the compositions A-M in a 4500lx +/-500 lx illumination box, a 40 ℃ constant temperature and humidity box and a 25 ℃ constant temperature and humidity box respectively, and taking out the compositions for observation in 7 days, 30 days and 30 days respectively. The stability results are given in the following table:
TABLE 1 summary of stability test results
The results show that compositions A-K have better stability and compositions F-M are prone to deterioration and off-taste.
Application and implementation:
table 2 shows the formula of massage essential oil containing the composition having the effect of repairing stretch marks, and the dosage of each substance is expressed by mass fraction.
Table 2 massage essential oil formula table for repairing striae gravidarum
The preparation method comprises the following steps: accurately weighing the raw materials and uniformly mixing.
Testing the human body temperature:
10 researchers are screened to carry out double-blind test of product mildness, 0.1g of each freshly prepared essential oil is respectively dripped on a specific area of an arm to be massaged and absorbed, and the using condition is recorded after 10 minutes. The test results are given in table 3 below:
table 3 massage essential oil mildness test results
"-" represents no abnormality.
The results show that as the use concentration of composition B increases, the mildness of the essential oil gradually decreases, suggesting that the maximum amount of composition B is recommended to be no more than 2%. Compared with two kinds of essential oil containing 0.01% of Olibanum extract, the ratio of allergy of the essential oil 2 using Olibanum extract alone is higher, and the addition of the essential oil 6 of composition B has no allergy. The essential oil 10-12 added with the composition K, L, M has no allergy phenomenon.
Testing the human body temperature after aging:
aging the essential oil sample, placing in a constant temperature and humidity box at 40 deg.C for 3 days, and taking out for use. Screening 10 research and development personnel to carry out double-blind test on the product mildness, respectively dropping 0.1g of the aged essential oil on a specific area of an arm for massage absorption, and recording the use condition, wherein the test results are as shown in the following table 4:
table 4 post-aging massage essential oil mildness test results
"-" represents no abnormality.
The results show that essential oil 2 after aging has a higher sensitization rate than before aging. Whereas the essential oil to which composition B was added was substantially consistent in mildness before and after aging. Suggesting greater stability for composition B. The essential oil 10-12 added with the composition K, L, M has allergy after aging.
Consumer efficacy testing
Purpose of the experiment
The test product was tried for 56 days by continuous human testing and the efficacy of the test product was clinically evaluated by instrumental testing and self-evaluation questionnaires.
Test subject
After screening by a professional dermatologist, 18 subjects were enrolled and finally 15 subjects completed the whole trial, of which 3 subjects exited the study for personal reasons.
Test product
Essential oil 2, essential oil 3, essential oil 4, essential oil 6 and essential oil 9. The efficacy of removing striae gravidarum is evaluated by a human body trial for 28 days.
Product usage method and frequency
A drop of essential oil is taken in the morning and at night each day and is smeared on the specific area of the striae gravidarum, and the striae gravidarum is massaged until the oil is completely absorbed.
Instrument test methods and results:
the skin elasticity is measured by a Cutomer, MPA580, and a parameter R2 (the ratio of the rebound amount without negative pressure to the maximum pull-up amount with negative pressure) is taken as the judgment basis of the skin elasticity. And D0 is compared with the data of D28 and D56 respectively, the elasticity increasing rate is calculated, and the average change value is obtained. The greater the change value, the better the skin elasticity improvement. The specific test results are shown in table 5 below:
table 5 skin elasticity test results
After 56 days of use, the testers were asked to fill out a questionnaire and to count the efficacy satisfaction scores, 1 score representing very unsatisfactory, 2 scores unsatisfactory, 3 scores normal, 4 scores satisfactory, 5 scores very satisfactory. The results are given in Table 6 below:
table 6 efficacy satisfaction results
The efficacy test result shows that the product efficacy and the customer satisfaction degree are obviously improved along with the increase of the addition concentration of the frankincense extract. The 1% and 2% compositions A are more effective. The effect satisfaction degree of the single application of the frankincense extract is low. Experiments prove that the composition for repairing striae gravidarum has more obvious efficacy and higher efficacy satisfaction than that of the frankincense extract used alone.
The above description is only exemplary of the invention, and any modification, equivalent replacement, and improvement made within the spirit and scope of the present invention should be considered within the scope of the present invention.
Claims (6)
1. The composition with the effect of repairing stretch marks is characterized by comprising the following components: olibanum extract, ascorbyl tetraisopalmitate, tocopherol acetate, jojoba oil;
the weight ratio of the frankincense extract, the ascorbyl tetraisopalmitate, the tocopherol acetate and the jojoba oil is as follows: 0.5:1-5:5-10: 84.5-93.5.
2. The composition with effect of repairing stretch marks according to claim 1, wherein the weight ratio of the frankincense extract, the ascorbyl tetraisopalmitate, the tocopherol acetate and the jojoba oil is as follows: 0.5: 1: 5: 93.5.
3. the composition with effect of repairing stretch marks according to claim 1, wherein the weight ratio of the frankincense extract, the ascorbyl tetraisopalmitate, the tocopherol acetate and the jojoba oil is as follows: 0.5: 5: 10: 84.5.
4. the composition with effect of repairing stretch marks according to claim 1, wherein the weight ratio of the frankincense extract, the ascorbyl tetraisopalmitate, the tocopherol acetate and the jojoba oil is as follows: 0.5: 5: 10: 84.5.
5. the composition with effect of repairing stretch marks according to claim 1, wherein the weight ratio of the frankincense extract, the ascorbyl tetraisopalmitate, the tocopherol acetate and the jojoba oil is as follows: 0.5: 3: 8: 88.5.
6. a nursing product with the effect of repairing striae gravidarum is characterized in that: containing 1-2% by weight of a composition according to any one of claims 1-5.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110363218.3A CN113101245A (en) | 2021-04-02 | 2021-04-02 | Composition and care product with effect of repairing stretch marks |
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| CN202110363218.3A CN113101245A (en) | 2021-04-02 | 2021-04-02 | Composition and care product with effect of repairing stretch marks |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114366690A (en) * | 2022-02-10 | 2022-04-19 | 广州天然国度生物科技有限公司 | Composition, application and cosmetic |
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2021
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Cited By (1)
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| CN114366690A (en) * | 2022-02-10 | 2022-04-19 | 广州天然国度生物科技有限公司 | Composition, application and cosmetic |
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