KR20110023531A - Cosmetic composition for improving bust drooping and elasticity - Google Patents

Abstract

PURPOSE: A cosmetic composition containing kigelia Africana fruit extract and fructose 1,6-diphosphate is provided to improve breast elasticity. CONSTITUTION: A cosmetic composition for improving breast elasticity contains 0.0001-50.0 weight% of kigelia Africana fruit extract and 0.0001-2.0 weight% of fructose 1,6-diphosphate or derivative thereof as active ingredient. The composition further contains pomegranate extract, soybean germ extract, or Artemisia Abrotanum extract isolated using water, ethanol, methanol, butanol, ether, ethyl acetate, chloroform, or mixture solvent of organic solvent and water.

Description

Cosmetic composition for improving sag and elasticity reduction {Cosmetic composition for improving bust drooping and elasticity}

The present invention relates to a cosmetic composition for improving breast sagging and elasticity reduction due to repeated diet, pregnancy, childbirth, natural aging, and more specifically, sausage tree for enhancing collagen synthesis of cutaneous tissue surrounding breasts. The present invention relates to a cosmetic composition for improving sagging and lowering of elasticity of a fruit extract (kigelia Africana fruit extract) and fructose 1,6-diphosphate (D-Fructose 1,6-diphosphate) or derivatives thereof as an active ingredient. In addition, the cosmetic composition according to the present invention further contains one more selected from the group consisting of pomegranate extract, soybean germ extract (Glycine Soja (Soybean) Germ Extract) and Southernwood extract (Southernwood; Artemisia Abrotanum extract) Excellent chest sagging and elasticity improvement effect can be exhibited.

Women's breasts are located between the 3rd and 7th ribs in front of the thorax and consist of mammary gland, adipose tissue and connective tissue. consist of. Of these, adipose tissue plays a role in determining the volume and intensity of the breast and makes up two thirds of the breast.They are sensitive to factors such as weight change, age, pregnancy, and lactation, which eventually causes female hormone estrogen. The volume of the chest decreases due to decreased secretion of (estrogen) or weakened growth of cells around the chest. In addition, as the body ages, the amount of collagen synthesis gradually decreases and forms change in the connective tissue surrounding the adipose tissue, causing the skin around the chest to lose elasticity and sag.

In modern society, women's breasts are recognized as a symbol of health and beauty, and many women are emerging as a sensitive issue for women to improve their shape, size and elasticity through plastic surgery with side effects and economic burdens. have. In addition, the decrease in breast elasticity and fat loss caused by metabolic abnormalities such as hormones, blood, fat, and bones in postmenopausal women make women feel a great loss of femininity, so the need and importance of bust firming products are more important than ever. It is becoming.

In order to solve such women's concerns, Korean Patent Laid-Open Publication No. 2003-0087680 discloses the production and neutral fat of NADPH (nicotinamide adenine dinucleotide phosphate) in fructose 1,6-diphosphate or its derivatives in adipocytes. It promotes the production of triglyceride, which promotes the differentiation of adipocytes, and when applied to the human body, increases breast circumference and improves skin elasticity.

Accordingly, the present inventors promote the differentiation of fat cells constituting the adipose tissue to promote and strengthen the production of neutral fat in the fat cells and to strengthen the connective tissues such as collagen or elastin forming the connective tissue surrounding the adipose tissue to increase the volume of the female breast. Efforts to find an active substance that increases and improves the angle of sagging breasts have shown that a composition containing both sausage fruit extract and fructose 1,6-diphosphate or its derivatives as an active ingredient is effective for women's breast development and elasticity. It has been found to be effective for recovery, especially for improving sagging breasts. In addition, it was found that there is an excellent improvement effect when the composition further contains one selected from the group consisting of pomegranate extract, soybean germ extract and Suddenwood extract has completed the present invention.

Accordingly, it is an object of the present invention to provide a cosmetic composition that can improve women's breast sagging and reduced elasticity.

In order to achieve the above object, the present invention provides a cosmetic composition for improving sagging or lowering elasticity containing sausage tree fruit extract and fructose 1,6-diphosphate or derivatives thereof as an active ingredient.

The cosmetic composition for improving sagging and elasticity reduction according to the present invention contains a sausage tree fruit extract and fructose 1,6-diphosphate or derivatives thereof, and the pomegranate extract, soybean germ extract and sudden wood extract By containing one or more of the (Artemisia Abrotanum extract), it prevents sagging of the chest due to various external and internal factors, and gives elasticity and volume.

Hereinafter, the present invention will be described more specifically.

The present invention contains a sausage tree fruit extract and fructose 1,6-diphosphate or its derivatives as an active ingredient to promote the differentiation of fat cells, thereby constituting the subcutaneous fat layer or activating the fat cells that make up most of the breast. The present invention relates to a cosmetic composition for improving breast sagging and lowering elasticity by increasing volume and improving collagen synthesis in connective tissue surrounding adipose tissue. The cosmetic composition according to the present invention preferably contains 0.0001 to 50.0% by weight of the sausage tree fruit extract and 0.0001 to 2.0% by weight of fructose 1,6-diphosphate or a derivative thereof. Derivatives of fructose 1,6-diphosphate used in the present invention include sodium and calcium salts of fructose 1,6 diphosphate, the derivatives are the same content as fructose 1,6-diphosphate Used as When the content of the sausage tree fruit extract and fructose 1,6-diphosphate is less than the suggested range, it is difficult to expect an increase in breast volume and sag improvement, and when exceeded, there is a fear of skin irritation.

In addition, the composition according to the present invention may further contain at least 0.0001 to 20.0% by weight of at least one of the pomegranate extract, soybean germ extract and Suddenwood extract in addition to the above components. When the content of the extract is less than 0.0001% by weight, it is difficult to expect an effect of increasing breast volume and sag, and when exceeding 20.0% by weight, skin irritation may occur.

The extracts used in the present invention can be used in the form of extracts extracted with water or organic solvent by methods well known in the art. The organic solvent used in the present invention may be selected from the group consisting of ethanol, methanol, butanol, ether, ethyl acetate, chloroform and a mixed solvent of these organic solvents and water, and preferably 80% ethanol is used. At this time, the extraction temperature is preferably 10 to 80 ℃, it can be extracted for 6 to 24 hours. If the extraction temperature and extraction time is out of the extraction efficiency may decrease or change of components may occur.

Cosmetic composition for increasing the volume and sagging breasts of the female breast according to the present invention is not particularly limited in the formulation, for example, supple cosmetics, nourishing cosmetics, massage cream, nourishing cream, pack, gel or skin adhesive type cosmetics It can be formulated as.

Hereinafter, the content of the present invention will be described in more detail through examples and test examples. These examples are provided only for understanding the contents of the present invention, and the scope of the present invention is not limited to these examples, and modifications, substitutions, and insertions commonly known in the art may be performed. This is also included in the scope of the present invention.

Experimental Example 1 Evaluation of the Promoting Effect of Fructose 1,6-Diphosphate and Sausage Fruit Extract on the Promoting Triglyceride (TG) Production in Adipose Cells

3T3-L1 cells, a mouse fibroblast cell line, were treated with DMEM (Dulbeco's modified eagles medium, GIBCO BRL, Life Technologues) medium containing 10% fetal bovine serum (FBS). The wells were attached to the culture plate at 1 × 10 ⁵ cells / well, after 2 days, exchanged with fresh DMEM (including 10% FBS) and incubated for 2 days. Then, induction of differentiation with DMEM containing 1 μg / ml insulin, 0.5 mM IBMX, 0.25 μM dexamethasone (containing 10% FBS), and after 2 days, exchanged with DMEM containing insulin for 5 days Incubated. After 5 days, the cells were replaced with normal medium (DMEM, 10% FBS) and cultured while observing until they changed into fat cells. Fructose 1,6-diphosphate and sausage tree fruit extract [Greentech Co., Ltd.] were treated at a concentration of 1 mM, respectively, and treatment was the same as the beginning of differentiation. The 3T3-L1 cells differentiated in this manner were washed three times with PBS and then harvested with extraction buffer (20 mM Tris, 1 mM EDTA and 1 mM 2-mercaptoethanol). The collected cells were passed six times with G26 needles on ice, followed by centrifugation at 5000x g, 4 ° C for 3 minutes, and only the supernatant was used for the experiment. The amount of TG was measured by color development using a GPO-Trinder kit purchased from Sigma Co., Ltd. (St. Louis, MO, USA), and the absorbance was measured at 540 nm with an ELISA reader. The results are shown in FIG. 1.

As shown in the results of Figure 1, it can be observed that the concentration of triglycerides in the fat cells treated with fructose 1,6-diphosphate and sausage tree fruit extract than the control, and also the protose 1 The concentration of triglyceride was greatest in adipocytes treated with, 6-diphosphate and sausage tree fruit extract simultaneously.

Test Example 2 Measurement of Collagen Biosynthesis Efficacy of Skin Cells

After culturing human fibroblasts in a 24-hole plate incubator, the components shown in Table 1 below were each replaced with a medium containing 1 mM. On day 3 of culture, 0.5 ml of DMEM medium containing 10% fetal calf serum was added to each well, followed by 10 μCi of L [2, 3, 4, 5- ³ H] -proline. After 24 hours, the media and cells in each well are scraped, washed in 5% Trichloroacetic acid (TCA) solution, and then dispensed into two test tubes. 1 unit / μl of genase (type I collagenase) was added and incubated at 37 ° C. for 90 minutes, and other test tubes were stored at 4 ° C. Thereafter, 0.05 ml of 50% trichloroacetic acid was added to all test tubes and allowed to stand at 4 ° C. for 20 minutes, followed by centrifugation at 12,000 rpm for 10 minutes, respectively. The supernatant and the precipitates were separated into liquid scintillation counters (LSC). The CPM (counts per minute) value was obtained, and collagen biosynthesis value (RCB; Relative Collagen Biosynthesis) was obtained for the control group and the experimental group based on Equation 1 below. The results are shown in Table 1 below as a comparison with the control group of 100.

NO Fructose 1,6-diphosphate Fructose 1,6-diphosphate sodium salt Sausage tree
Fruit extract Soybean embryo
extract Pomegranate
extract Suddenwood
extract Collagen Biosynthesis Ratio RCB (%) One One - - - - - 110 2 - One - - - - 108 3 - - One - - - 130 4 - - - One - - 122 5 - - - - One - 118 6 - - - - - One 107 7 One - One - - - 143 8 One - One One - - 155 9 One - One - One - 149 10 One - One - - One 147 11 One - One One One One 160 12 - One One One One One 158 13 - - - - - - 100

As can be seen from the results of Table 1, fructose 1,6-diphosphate and its derivatives, sausage tree fruit extract, soybean germ extract, pomegranate extract and Suddenwood extract each increased collagen biosynthesis, in particular The combination of fructose 1,6-diphosphate and sausage fruit extract at the same time had better effect on collagen biosynthesis than when used alone. Also, sausage fruit extract and fructose 1,6-diphosphate were used. When the combination contains more than one type of soybean embryo extract, pomegranate extract and Suddenwood extract was confirmed to show a better synergistic effect. This is similar when the fructose 1,6-diphosphate is replaced with a derivative.

Example 1 and Comparative Examples 1 and 2

The cosmetic compositions of Example 1 and Comparative Examples 1 and 2 were prepared according to the compositions shown in Table 2 below.

<Production method>

The oily parts (raw materials 1 to 9) were dissolved in a separate container by heating to 70 ° C. in a separate container and then dispersed using a homogenizer. The water phase parts (raw materials 10 to 20) were heated to 70 ° C. to dissolve, and the oil phase parts were slowly added to the water phase parts and emulsified at 70 ° C. Finally, the composition was filled into an airtight container and cooled to room temperature using a cooler. After cooling, a creamy formulation was prepared.

NO Raw material name Example 1 Comparative Example 1 Comparative Example 2 One Caprylic / capric triglyceride 2.00 2.00 2.00 2 Hydrogenated C6-14 Olefin Polymer 2.00 2.00 2.00 3 Pentaerythritol tetraethylhexanoate 2.00 2.00 2.00 4 2-octyldodecanol 2.00 2.00 2.00 5 Limantes Alba (medium foam) seed oil (medium foam seed (seed) oil) 2.00 2.00 2.00 6 Cetyl alcohol 1.00 1.00 1.00 7 Glyceryl Stearate / Ceteares-20 / Ceteares-12 / Cetearyl Alcohol / Cetyl Palmitate 3.00 3.00 3.00 8 Chin type glyceryl stearate 1.00 1.00 1.00 9 Dimethicone 1.00 1.00 1.00 10 Purified water 70.75 76.25 73.75 11 Disodium ID 0.05 0.05 0.05 12 Glycerin (concentrated glycerin) 5.00 5.00 5.00 13 Propanediol 2.00 2.00 2.00 14 Phenoxyethanol 0.30 0.30 0.30 15 Polyacrylate-13 * polyisobutene * polysorbate 20 0.40 0.40 0.40 16 Soybean Germ Extract 0.50 - 0.50 17 Suddenwood Extract 0.50 - 0.50 18 Pomegranate extract 0.50 - 0.50 19 Sausage Tree Fruit Extract 3.00 - - 20 Fructose 1,6-diphosphate 1.00 - 1.00

[Test Example 3] Evaluation of the volume increase effect in the female breast

BMI (Body Mass Index, weight (kg) / height (m) ² ) 40 female subjects 21-30 years old with 21-27 divided into two groups of four weeks to the composition of Example 1 and Comparative Examples 1-2 During the morning and evening shower twice a day for use with the user's massage was to compare the use before and after 2 weeks, 4 weeks after the use of the effect was judged. The measurement was performed by three-dimensional measuring device PRIMOS Body (GFMesstechnik, Germany) three-dimensional measurement of the chest area using the images taken, using the PRIMOS Body 6.7 (GFMesstechnik, Germany) program to measure the length of the curve of the skin surface After the measurement, a line was drawn perpendicular to the body with the nipple as the center, and the curvature of the skin surface corresponding to the line was measured in mm, and the result is shown in FIG. 2.

In the evaluation of breast volume increase rate after 4 weeks of use of each product of FIG. 2, the women's breast volume increased by 0.4% over 4 weeks when using Comparative Example 1, whereas 2.7% at 2 weeks using Example 1, Statistically significantly increased to 3.4% at 4 weeks, using Comparative Example 2 had a statistically significant increase in breast volume by 1.6% at 2 weeks, 2.5% after 4 weeks. Based on the experimental results, both Example 1 and Comparative Example 2 had an effect of increasing the volume of the female breast, and it can be seen that Example 1 has a more excellent effect than that of Comparative Example 2.

[Test Example 4] Evaluation of the improvement of sagging of the female breast

BMI (Body Mass Index, weight (kg) / height (m) ² ) was divided into three groups of 30 female subjects aged 21-30 with 21-27, the cosmetic composition of Example 1 and Comparative Examples 1-2 After the morning and evening shower twice a week, the user was allowed to use with the massage and the effect was judged by comparing the use before and after 2 weeks, 4 weeks. After using the digital camera, the chest side photographs were taken before and after using the product. The images were analyzed with the image-pro plus program, an image analysis program. The distance was measured, and the distance difference before and after using the product was calculated, and the result is shown in FIG. 3.

In the results of measuring the increase in the height of the teat to measure the effect of improving breast sagging after using the 4 weeks of FIG. 3.4% increase in 4 weeks. In addition, Comparative Example 2 showed an increase of 1.0% at 2 weeks and 1.5% at 4 weeks, indicating that the effects of sausage tree fruit extract and fructose 1,6-diphosphate were effective in improving sagging breasts. there was.

1 is a graph showing the results of a test for evaluation of the promotion of neutral fat production in fat cells by fructose 1,6-diphosphate and sausage fruit extract.

Figure 2 is a graph showing the results of measuring the breast volume increase rate after using the cosmetic compositions of Examples 1 and Comparative Examples 1 and 2 for 4 weeks.

Figure 3 is a graph showing the results of measuring the increase rate of the teat height to measure the effect on the improvement of breast sagging after using the cosmetic compositions of Examples 1 and Comparative Examples 1 and 2 for 4 weeks.

Claims (4)

A cosmetic composition for improving sagging or lowering of elasticity, comprising sausage tree fruit extract and fructose 1,6-diphosphate or a derivative thereof as an active ingredient. According to claim 1, wherein the composition is a cosmetic composition for improving sagging or lowering of elasticity, characterized in that it comprises 0.0001 to 50.0% by weight of the sausage tree fruit extract based on the total weight of the composition. According to claim 1, wherein the composition is a cosmetic composition for improving sagging or lowering elasticity, characterized in that it contains 0.0001 to 2.0% by weight of fructose 1,6-diphosphate or derivatives thereof relative to the total weight of the composition According to claim 1, wherein the composition is a cosmetic composition for improving sagging or lowering elasticity, characterized in that it further contains one or more selected from the group consisting of pomegranate extract, soybean embryo extract and Southernwood extract as an active ingredient .

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