WO2022142888A1 - Traditional chinese medicine lip balm having yin nourishment and internal heat relief effects, and method for preparation thereof - Google Patents
Traditional chinese medicine lip balm having yin nourishment and internal heat relief effects, and method for preparation thereof Download PDFInfo
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- 230000029663 wound healing Effects 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Definitions
- the invention relates to the technical field of cosmetics, in particular to a traditional Chinese medicine lipstick with the functions of nourishing yin and clearing heat and a preparation method thereof.
- the lips are different from other skin parts. Compared with ordinary skin, the stratum corneum of the lips is thinner and the water content is lower, so the lips are prone to wrinkles, dehydration, chapped and other problems. There are many kinds of lipsticks on the market now, but the good and the bad are mixed, and inferior lipsticks can cause many lip diseases and internal damage.
- lip balm lipstick
- the primary purpose of the present invention is to overcome the shortcomings and deficiencies of the prior art, and to provide a traditional Chinese medicine lip balm with the effect of nourishing yin and clearing away heat.
- Another object of the present invention is to provide a preparation method of the above-mentioned traditional Chinese medicine lipstick with nourishing yin and heat-clearing effects.
- a traditional Chinese medicine lip balm with the functions of nourishing yin and clearing away heat comprising the following raw materials in parts by weight: 5-10 parts of traditional Chinese medicine extract, 10-20 parts of beeswax, 20-40 parts of olive oil, and 5-10 parts of vitamin E oil;
- the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 5-20 parts of Ligustrum lucidum extract, 5-20 parts of Eclipta chinensis extract, 5-20 parts of Artemisia annua extract, honeysuckle flower Extract 5 to 20 copies.
- the traditional Chinese medicine lip balm includes the following raw materials in parts by weight: 6 parts of traditional Chinese medicine extract, 10 parts of beeswax, 30 parts of olive oil, and 5 parts of vitamin E oil.
- the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 20 parts of Ligustrum lucidum extract, 20 parts of Eclipta chinensis extract, 10 parts of Artemisia annua extract, and 10 parts of honeysuckle extract.
- the raw material also includes at least one of edible toner, essence and flower wax; more preferably, it also includes 0.5-5 parts by weight of edible toner and 0.5-5 parts of essence And flower wax 5 to 20 copies.
- Edible toners are prepared according to different colors.
- the above-mentioned preparation method of the traditional Chinese medicine lip balm with nourishing yin and heat-clearing effect comprises the following steps:
- step S3 mix beeswax and olive oil, heat until melted, and shake well; add vitamin E oil in turn, the extracts of various traditional Chinese medicine raw materials prepared in step S1, and shake well; pour the resulting mixture into a film, and wait for cooling to solidify to obtain the obtained lip balm; when the raw material includes edible toner, mix beeswax and olive oil, heat until melted, and shake well; first add vitamin E oil, shake well; then add edible toner, shake well; finally add The extracts of various traditional Chinese medicine raw materials are shaken well; the obtained mixture is poured into a film, and the lip balm is obtained after cooling and solidification.
- the sieving is preferably a 50-60 mesh sieve; more preferably, when the raw material of the traditional Chinese medicine is Ligustrum lucidum, it is passed through a 50-mesh sieve, and when the raw material of the traditional Chinese medicine is Eclipta chinensis, Artemisia annua or honeysuckle, Pass through a 60-mesh sieve.
- the water is preferably sterile distilled water.
- the weight of water is 10 to 16 times the weight of the medicinal material, and the soaking time is 4 to 6 hours; , the weight of water is 6 to 10 times the weight of the medicinal material, and the soaking time is 4 to 6 hours.
- the steam distillation method is preferably carried out according to the "2204 Volatile Oil Determination Method" of "Chinese Pharmacopoeia” 2015 edition.
- the reagent used for drying is preferably anhydrous sodium sulfate.
- the pore size of the microporous membrane used for filtration is preferably 0.22 ⁇ m.
- the heating temperature is preferably 70-90°C; more preferably 80°C.
- the invention carries out the compatibility of the monarch, ministers, assistants and envoys according to the traditional Chinese medicine prescriptions and the traditional Chinese medicine extracts with medicinal therapeutic effect, so as to achieve different therapeutic purposes.
- the traditional Chinese medicine lip balm of the present invention takes the traditional Chinese medicine prescription as a formula guidance method, selects a single extract of a traditional Chinese medicine for compatibility, adds corresponding basic materials according to different traditional Chinese medicine dosage ratios in the prescription, selects the prescription two to pills for addition and subtraction, Beeswax, olive oil and vitamin E oil are simultaneously added to the traditional Chinese medicine extracts (Ligustrum lucidum, Eclipta chinensis, Artemisia annua, and honeysuckle) to exert a synergistic effect, so that when the composition is used as a skin care product and a cosmetic, it has a long-lasting effect.
- the moisturizing effect can prolong the action time of traditional Chinese medicine ingredients, promote the absorption and utilization of many traditional Chinese medicine ingredients by the lip skin, and enhance the effects of traditional Chinese medicine ingredients on the lip skin of nourishing yin, moisturizing, clearing heat and reducing swelling, hemostasis and lip care.
- the proportion of traditional Chinese medicine extracts are prepared according to the proportions of various traditional Chinese medicines in the traditional Chinese medicine prescription.
- traditional Chinese medicine prescriptions the medicines in it are divided into monarch, minister and assistant, namely monarch medicine, minister medicine, adjuvant medicine, and envoy medicine.
- "Jun” medicine is the medicine that treats the main syndrome and plays a major role in the prescription. It can be used in one or several flavours as needed.
- "Chen” medicine is a medicine that assists the main medicine to play a therapeutic role.
- Adjuvant is a medicine that assists the main medicine to treat the concurrent syndrome or suppresses the toxicity and strong taste of the main medicine, or is a counter-adjuvant medicine.
- “Making” medicine is to guide each medicine directly to the location of the disease or have the effect of reconciling each medicine. Through the compatibility of different traditional Chinese medicines, different traditional Chinese medicine prescriptions are formed, which have different therapeutic effects.
- Ligustrum lucidum flat in nature, sweet and bitter in taste, it belongs to the liver and kidney meridians, and has the functions of nourishing yin and longevity, nourishing liver and kidney, clearing heat and improving eyesight, black hair and black hair. It is generally used to treat dizziness, tinnitus, dark eyes, waist and knee pain, internal heat, premature graying of beard and hair and other symptoms.
- Eclipta nature and flavor return to meridian: sweet and sour, cool. Efficacy: cooling blood, hemostasis, invigorating kidney, benefiting yin. Indications: Treatment of hematemesis, hemoptysis, epistaxis, hematuria, blood in the stool, blood dysentery, bleeding from knife wounds, premature whitening of hair and beard, diphtheria, stranguria, vaginal discharge, wet itching of the genitals, and mouse mole.
- Artemisia annua It has the effects of clearing deficiency heat, removing bone steaming, relieving summer heat, cutting malaria, and relieving jaundice. It is often used in the treatment of diseases such as warm pathogens injuring yin, night heat and early coolness, yin deficiency fever, bone steaming labor fever, summer pathogenic fever, malaria cold and heat, damp-heat jaundice and other diseases.
- Honeysuckle sweet and cold in nature; return to the lung and stomach meridians. The effect is to clear away heat and detoxify, reduce inflammation and reduce swelling. Indications are exogenous wind-heat or febrile disease fever, heat stroke, heat toxin blood dysentery, carbuncle swollen furuncle, throat paralysis, various infectious diseases.
- Beeswax The wax secreted by the honey bee insect, the Chinese honey bee or the Italian bee.
- the honeycomb is heated in water, filtered, condensed to get wax or refined again.
- This product is irregular lumps of different sizes. Yellow, yellowish-brown or yellowish-white, opaque or slightly transparent, smooth surface.
- the body is light, waxy, and the section is gritty, which can be softened by hand rubbing and kneading. It has a honey-like aroma, slightly sweet taste, and returns to the spleen meridian. It has the functions of detoxification, astringing sores, muscle regeneration, and pain relief.
- Olive oil It is a woody vegetable oil, which is directly cold-pressed from fresh olive fruit without heating and chemical treatment, and retains natural nutrients. Olive oil is considered to be the most suitable for human nutrition among the oils found so far. grease. Olive oil is rich in squalene and essential fatty acids that have excellent affinity with the skin, which is quickly absorbed and effectively maintains skin elasticity and moisture; olive oil is rich in monounsaturated fatty acids and vitamins E, K, A, D, etc.
- Phenolic antioxidants can eliminate facial wrinkles, prevent skin aging, have skin care and hair care and prevent and treat chapped hands and feet, reduce gastric acid, prevent gastritis and duodenal ulcers and other diseases; and stimulate bile secretion , to activate the activity of pancreatic enzymes, so that the lipids are degraded and absorbed by the intestinal mucosa, so as to reduce the occurrence of cholecystitis and gallstones. It also has the function of moistening the intestines, and long-term consumption can effectively relieve constipation.
- the chlorophyll in olive oil plays a role in metabolism, promotes cell growth and accelerates wound healing. Experiments have shown that the antioxidants contained in olive oil can eliminate free radicals in the body, restore the health of human organs, prevent brain aging, and prolong life.
- Vitamin E It is a fat-soluble vitamin, and its hydrolysis product is tocopherol, which is one of the most important antioxidants and has an antioxidant effect. It is soluble in organic solvents such as fat and ethanol, insoluble in water, stable to heat and acid, unstable to alkali, sensitive to oxygen and insensitive to heat. It is widely used in clinical practice.
- Applicable people People with sub-healthy kidney yin deficiency, liver and kidney yin deficiency, prone to dry and cracked lips, or accompanied by swelling or bleeding, or accompanied by dizziness, tinnitus, dry throat, dry nose, waist and knee pain, heavy menstrual flow, etc.
- the traditional Chinese medicine lip balm of the present invention has a better therapeutic effect in addition to moisturizing the lips and protecting the lips, has the effect of nourishing yin and clearing away heat, and is an ideal lip care product.
- the functional components used in the traditional Chinese medicine lip balm of the present invention are all natural plant sources, mild, non-irritating, and high in safety.
- the traditional Chinese medicine lip balm of the present invention simultaneously adds beeswax, olive oil, and vitamin E oil to the traditional Chinese medicine extract, which is reasonably compatible, exerts a synergistic effect, has a long-term moisturizing effect, can prolong the action time of the traditional Chinese medicine ingredient, and promotes the skin on the lips.
- the absorption and utilization of many traditional Chinese medicine ingredients can improve the effect of traditional Chinese medicine ingredients on lip skin in nourishing yin, moisturizing, clearing heat and reducing swelling, hemostasis and lip protection.
- the traditional Chinese medicine lip balm of the present invention has a wide range of raw materials, simple and convenient manufacturing process, low cost and wide application prospect.
- a traditional Chinese medicine lip balm made of a composition with the functions of nourishing yin and clearing heat is prepared from the following raw materials by weight: 6 parts of traditional Chinese medicine extracts, 10 parts of beeswax, 30 parts of olive oil and 5 parts of vitamin E oil. In practical application, appropriate amount of edible toner can be added to mix different colors without affecting the efficacy.
- the traditional Chinese medicine extracts include Ligustrum lucidum extract, Eclipta japonica extract, Artemisia annua extract, and honeysuckle extract, and are prepared from the following raw materials by weight: 20 parts of Ligustrum lucidum extract, 20 parts of Eclipta japonica extract 10 parts of Artemisia annua extract, 10 parts of honeysuckle extract.
- the specific preparation steps are as follows:
- 2Instrument device a hard round-bottomed flask, connected with a volatile oil measuring device, and the upper end of the volatile oil measuring device is connected with a reflux condenser. All the above parts are connected with glass grinding mouth. All instruments are fully cleaned, and the joints are checked to ensure tightness to prevent volatile oil from escaping.
- Ligustrum lucidum Weigh 70 g of Ligustrum lucidum powder, put it in a hard round-bottomed flask, add 1 L of sterile distilled water, and soak for 5 hours before extraction. About 3 mL of n-hexane was added to the upper end of the volatile oil measuring device, refluxed for extraction for 5 hours, allowed to stand, and the volume of n-hexane was supplemented to 3 mL. The n-hexane layer was taken, dried by adding anhydrous sodium sulfate and left to stand overnight. The supernatant was taken and passed through a 0.22 ⁇ m microporous membrane for use.
- Eclipta japonica, Artemisia annua, and honeysuckle Weigh 60 g of the pulverized Eclipta japonica, Artemisia annua, and honeysuckle powder, put them in a hard round-bottomed flask, add 500 mL of sterile distilled water, and soak for 5 hours. After reflux extraction for 5 hours, the volume of n-hexane was adjusted to 2 mL (about 1 mL of n-hexane was added to the collection tube of the volatile oil extractor). The n-hexane layer was taken, dried by adding anhydrous sodium sulfate and left to stand overnight. The supernatant was taken and passed through a 0.22 ⁇ m microporous membrane for use.
- Table 1 The dosage of Chinese medicine extract, beeswax, olive oil and vitamin E oil in parts by weight
- Example 3 20 20 10 20 Example 4 20 20 20 20 Example 5 20 20 5 5 Example 6 20 10 10 10 Example 7 20 30 10 10 10 Example 8 10 20 10 10 Example 9 10 10 20 20 Example 10 5 5 20 20
- Comparative Example 1 The difference between Comparative Example 1 and Example 1 is that olive oil was omitted, and the amount of beeswax was adjusted to 40 parts, and other operations were the same as those of Example 1.
- Comparative Example 2 The difference between Comparative Example 2 and Example 1 is that the traditional Chinese medicine extract is omitted, and other operations are the same as those of Example 1.
- Comparative Example 3 The difference between Comparative Example 3 and Example 1 is that vitamin E oil is omitted, and other operations are the same as those of Example 1.
- Example 1 and Comparative Example 1 -3 For the prepared product, use a skin detector (Real Bubee, RBX-916) to measure the lip moisture content before use, 20 minutes after use, 2 hours after use and 4 hours after use, and count the skin moisture content of each group of volunteers , calculate the average. The results are shown in Table 3.
- Example 1 is better than Comparative Examples 1-3
- Comparative Example 3 is better than Comparative Example 2
- Comparative Example 2 is better than Comparative Example 1.
- Comparative Example 1 showed a significant moisturizing effect only after 15 minutes of use, and then the moisturizing effect was poor.
- Comparative Example 2 and Comparative Example 3 are less moisturizing than Example 1. It can be seen that this product combines Chinese herbal extracts with beeswax, olive oil and vitamin E oil, which play a synergistic effect with each other, improve the long-term moisturizing performance of the product, and can promote the skin to utilize the active ingredients of Chinese herbal medicine in a short time, improve the moisturizing effect. Yin moisturizing effect.
- kidney-yin deficiency syndrome in sub-health state [1-2] : 1Shenzhen kidney deficiency syndrome is mainly manifested by low back pain, weak legs and knees, fatigue, tinnitus, hair loss, etc.; 2Yin fluid deficiency The main manifestations are dry lips or accompanied by bleeding, astringent eyes, dry throat, dry stool, etc. 3 Yin deficiency and fire, heat disturbing the mind, etc. The manifestations are mainly night sweats, palm fever, insomnia and dreaming, etc. 4 Sub-healthy tongue and pulse of kidney yin deficiency syndrome Mainly with red tongue and thin pulse;
- Exclusion criteria patients with major diseases, infectious diseases or coagulation disorders; patients with mental illness and major physical diseases; patients who have lost or do not have the ability to make independent judgments.
- TCM clinical symptoms and signs are significantly improved, and syndrome scores are reduced by ⁇ 70%;
- TCM clinical symptoms and signs have improved, and syndrome scores have been reduced by ⁇ 30%;
- this product combines Chinese herbal extracts with beeswax, olive oil and vitamin E oil, which play a synergistic effect with each other, improve the product's yin-nourishing and heat-clearing performance, and can promote the skin to utilize the active ingredients of traditional Chinese medicines within a time. Nourishing and moisturizing effect.
- Example 1 0 2 4 100%
- Example 2 1 2 3 83%
- Example 3 0 3 3 100%
- Example 4 1 2 3 83%
- Example 5 1 5 0 83%
- Example 6 1 2 3 83%
- Example 7 1 4 1 83%
- Example 8 1 3 2 83%
- Example 9 0 2 4 100%
- Example 10 1 4 1 83% Comparative Example 1 4 2 0 33% Comparative Example 2 5 1 0 17% Comparative Example 3 4 2 0 33%
- mice (commercially available), 16 males, weighing 18-22 g, were raised in an SPF environment.
- mice 16 male BALB/c mice were raised in an SPF environment and divided into 8 mice in the control group and 8 mice in the experimental group (Example 1). During the experiment, the hair on the back of the mice was shaved with a razor, with an area of about 3cm*3cm. The mice in the experimental group were smeared with traditional Chinese medicine lip balm on the back depilation area every day, while the mice in the control group were smeared with Vaseline ointment in the same amount and in the same way, once a day, for a week.
- mice in the experimental group did not have abnormal skin dryness, roughness, thickening, redness and swelling, and no abnormal behaviors such as restlessness or malaise.
- Ligustrum lucidum extract essential oil
- Eclipta japonica extract essential oil
- Artemisia annua extract essential oil
- honeysuckle extract essential oil
- Cell source select human keratinocytes (Hacat, purchased from Biyuntian, product model C6282)
- HERACELL 150i Ultra-clean workbench (HFsafe-1200LC); microscope (Nikon eclicse TS100-F); microplate reader (Spectra Max M2); centrifuge (SIGMA 3K15); Fine Medical Instrument Factory).
- Cells were collected, counted on a cell counter, adjusted to 4 ⁇ 10 4 cells/ml, inoculated into a 96-well plate, and cultured for 24 hours for later use. 1% DMSO was added to the culture medium as a solubilizer. Cells were collected, counted on a cell counter, adjusted to 4 ⁇ 10 4 cells/ml, inoculated into a 96-well plate, and cultured for 24 hours for later use.
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Abstract
Provided are a traditional Chinese medicine lip balm having Yin nourishment and internal heat relief effects, and a method for preparation thereof, belonging to the field technical field of cosmetics. The traditional Chinese medicine lip balm of the present invention comprises the following raw materials by weight: 5–10 parts of Chinese medicinal extract, 10–20 parts of beeswax, 20–40 parts of olive oil, and 5–10 parts of vitamin E oil; said Chinese medicinal extract is prepared from the following raw materials by weight: 5–20 parts of Fructus ligustri lucidi extract, 5–20 parts of Eclipta prostrata extract, 5–20 parts of Artemisiae annuae herba extract, and 5–20 parts of honeysuckle extract. The components of the traditional Chinese medicinal lip balm of the present invention are combined in a reasonable way, exhibit a synergistic function, have a long-lasting moisturizing effect, can prolong the time of effectiveness of Chinese medicinal ingredients, promote the absorption and utilization of more Chinese medicinal ingredients by the skin of the lips, enhance the effectiveness of the Chinese medicinal ingredients on nourishing Yin and moisturizing the skin of the lips, clearing internal heat and reducing swelling, stanching blood, and protecting the lips, and have a wide range of prospects for application.
Description
本发明涉及化妆品技术领域，尤其涉及一种具有滋阴清热功效的中药唇膏及其制备方法。The invention relates to the technical field of cosmetics, in particular to a traditional Chinese medicine lipstick with the functions of nourishing yin and clearing heat and a preparation method thereof.
唇部和其他的皮肤部位不同，和普通皮肤相比唇部的角质层较薄而且含水量较低，因此唇部易出现皱纹、失水、皲裂等问题。现在市场上唇膏种类繁多但良莠不齐，劣质唇膏会造成诸多口唇疾病和内在伤害。The lips are different from other skin parts. Compared with ordinary skin, the stratum corneum of the lips is thinner and the water content is lower, so the lips are prone to wrinkles, dehydration, chapped and other problems. There are many kinds of lipsticks on the market now, but the good and the bad are mixed, and inferior lipsticks can cause many lip diseases and internal damage.
因此，唇膏(口红)的改进和创新是目前亟需解决的问题。Therefore, the improvement and innovation of lip balm (lipstick) is an urgent problem to be solved at present.
发明内容SUMMARY OF THE INVENTION
本发明的首要目的在于克服现有技术的缺点与不足，提供一种具有滋阴清热功效的中药唇膏。The primary purpose of the present invention is to overcome the shortcomings and deficiencies of the prior art, and to provide a traditional Chinese medicine lip balm with the effect of nourishing yin and clearing away heat.
本发明的另一个目的在于提供上述具有滋阴清热功效的中药唇膏的制备方法。Another object of the present invention is to provide a preparation method of the above-mentioned traditional Chinese medicine lipstick with nourishing yin and heat-clearing effects.
本发明的目的通过下述技术方案实现：The object of the present invention is achieved through the following technical solutions:
一种具有滋阴清热功效的中药唇膏，包括以下按重量份数计的原料：中药提取物5～10份、蜂蜡10～20份、橄榄油20～40份、维生素E油5～10份；其中，所述中药提取物由以下按重量份数计的原料制备而成：女贞子提取物5～20份、墨旱莲提取物5～20份、青蒿提取物5～20份、金银花提取物5～20份。A traditional Chinese medicine lip balm with the functions of nourishing yin and clearing away heat, comprising the following raw materials in parts by weight: 5-10 parts of traditional Chinese medicine extract, 10-20 parts of beeswax, 20-40 parts of olive oil, and 5-10 parts of vitamin E oil; Wherein, the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 5-20 parts of Ligustrum lucidum extract, 5-20 parts of Eclipta chinensis extract, 5-20 parts of Artemisia annua extract, honeysuckle flower Extract 5 to 20 copies.
优选的，所述中药唇膏包括以下按重量份数计的原料：中药提取物6份、蜂蜡10份、橄榄油30份、维生素E油5份。Preferably, the traditional Chinese medicine lip balm includes the following raw materials in parts by weight: 6 parts of traditional Chinese medicine extract, 10 parts of beeswax, 30 parts of olive oil, and 5 parts of vitamin E oil.
优选的，所述中药提取物由以下按重量份数计的原料制备而成：女贞子提取物20份、墨旱莲提取物20份、青蒿提取物10份、金银花提取物10份。Preferably, the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 20 parts of Ligustrum lucidum extract, 20 parts of Eclipta chinensis extract, 10 parts of Artemisia annua extract, and 10 parts of honeysuckle extract.
优选的，所述的原料还包括可食用色粉、香精和花蜡中的至少一种；更优选的，还包括按重量份数计的可食用色粉0.5～5份、香精0.5～5份和花蜡5～20份。可食用色粉根据不同颜色调配。Preferably, the raw material also includes at least one of edible toner, essence and flower wax; more preferably, it also includes 0.5-5 parts by weight of edible toner and 0.5-5 parts of essence And flower wax 5 to 20 copies. Edible toners are prepared according to different colors.
上述具有滋阴清热功效的中药唇膏的制备方法，包括以下步骤：The above-mentioned preparation method of the traditional Chinese medicine lip balm with nourishing yin and heat-clearing effect, comprises the following steps:
S1、将各种中药原料分别粉碎，过筛，得到各种中药原料的粉末；S1, pulverize and sieve various traditional Chinese medicine raw materials respectively to obtain the powder of various traditional Chinese medicine raw materials;
S2、分别取各种中药原料的粉末，加水，浸泡，用水蒸气蒸馏法提取挥发油，提取液经干燥，过滤，即得到各种中药原料的提取物；S2, respectively take the powder of various traditional Chinese medicine raw materials, add water, soak, extract volatile oil by steam distillation, and the extract is dried and filtered to obtain the extracts of various traditional Chinese medicine raw materials;
S3、将蜂蜡和橄榄油混合，加热至融化，摇匀；依次加入维生素E油，步骤S1制备的 各种中药原料的提取物，摇匀；将所得混合物倒膜，待冷却凝固，即获得所述润唇膏；当原料中包括可食用色粉时，将蜂蜡和橄榄油混合，加热至融化，摇匀；先加入维生素E油，摇匀；然后加入可食用色粉，摇匀；最后再加入各种中药原料的提取物，摇匀；将所得混合物倒膜，待冷却凝固，即获得所述润唇膏。S3, mix beeswax and olive oil, heat until melted, and shake well; add vitamin E oil in turn, the extracts of various traditional Chinese medicine raw materials prepared in step S1, and shake well; pour the resulting mixture into a film, and wait for cooling to solidify to obtain the obtained lip balm; when the raw material includes edible toner, mix beeswax and olive oil, heat until melted, and shake well; first add vitamin E oil, shake well; then add edible toner, shake well; finally add The extracts of various traditional Chinese medicine raw materials are shaken well; the obtained mixture is poured into a film, and the lip balm is obtained after cooling and solidification.
所述的步骤S1中，过筛优选为过50～60目筛；更优选的，当中药原料为女贞子时，过50目筛，当中药原料为墨旱莲、青蒿或金银花时，过60目筛。In the described step S1, the sieving is preferably a 50-60 mesh sieve; more preferably, when the raw material of the traditional Chinese medicine is Ligustrum lucidum, it is passed through a 50-mesh sieve, and when the raw material of the traditional Chinese medicine is Eclipta chinensis, Artemisia annua or honeysuckle, Pass through a 60-mesh sieve.
所述的步骤S2中，水优选为无菌蒸馏水。In the step S2, the water is preferably sterile distilled water.
所述的步骤S2中，当中药原料为女贞子时，水的重量为药材重量的10～16倍，浸泡的时间为4～6小时；当中药原料为墨旱莲、青蒿或金银花时，水的重量为药材重量的6～10倍，浸泡的时间为4～6小时。In the described step S2, when the traditional Chinese medicine raw material is Ligustrum lucidum, the weight of water is 10 to 16 times the weight of the medicinal material, and the soaking time is 4 to 6 hours; , the weight of water is 6 to 10 times the weight of the medicinal material, and the soaking time is 4 to 6 hours.
所述的步骤S2中，水蒸气蒸馏法优选按《中国药典》2015版“2204挥发油测定法”进行。In the step S2, the steam distillation method is preferably carried out according to the "2204 Volatile Oil Determination Method" of "Chinese Pharmacopoeia" 2015 edition.
所述的步骤S2中，干燥所用的试剂优选为无水硫酸钠。In the step S2, the reagent used for drying is preferably anhydrous sodium sulfate.
所述的步骤S2中，过滤所用的微孔滤膜的孔径优选为0.22μm。In the step S2, the pore size of the microporous membrane used for filtration is preferably 0.22 μm.
所述的步骤S3中，加热的温度优选为70～90℃；更优选为80℃。In the step S3, the heating temperature is preferably 70-90°C; more preferably 80°C.
目前存在的中药类护肤品很少根据中医基础理论指导的方剂处方来配伍，而现在此发明为根据中医基础理论指导，结合具有药用治疗效果的中药提取物进行不同比例配伍，达到不同的治疗目的。The existing traditional Chinese medicine skin care products are rarely compatible according to the prescriptions guided by the basic theory of traditional Chinese medicine, and now this invention is based on the basic theory of traditional Chinese medicine, combined with the traditional Chinese medicine extracts with medicinal therapeutic effects. Purpose.
本发明根据中医基础理论指导，按中药方剂，结合具有药用治疗效果的中药提取物进行君臣佐使的配伍，达到不同的治疗目的。本发明的中药药唇膏，是以中医药方剂处方为配方指导方法，选取中药单方提取物进行配伍，根据方剂中不同的中药量比例加入相应的基础材料，选取方剂二至丸进行加减，在中药提取物(女贞子、墨旱莲、青蒿、金银花)中同时添加蜂蜡、橄榄油、维生素E油，发挥协同增效作用，使得该组合物作为护肤品及化妆品使用时，具有长效保湿功效，可延长中药成分的作用时间，促进唇部皮肤对中药成分多的吸收利用，提升中药成分对唇部皮肤的滋阴保湿、清热消肿、止血护唇的功效。According to the guidance of the basic theory of traditional Chinese medicine, the invention carries out the compatibility of the monarch, ministers, assistants and envoys according to the traditional Chinese medicine prescriptions and the traditional Chinese medicine extracts with medicinal therapeutic effect, so as to achieve different therapeutic purposes. The traditional Chinese medicine lip balm of the present invention takes the traditional Chinese medicine prescription as a formula guidance method, selects a single extract of a traditional Chinese medicine for compatibility, adds corresponding basic materials according to different traditional Chinese medicine dosage ratios in the prescription, selects the prescription two to pills for addition and subtraction, Beeswax, olive oil and vitamin E oil are simultaneously added to the traditional Chinese medicine extracts (Ligustrum lucidum, Eclipta chinensis, Artemisia annua, and honeysuckle) to exert a synergistic effect, so that when the composition is used as a skin care product and a cosmetic, it has a long-lasting effect. The moisturizing effect can prolong the action time of traditional Chinese medicine ingredients, promote the absorption and utilization of many traditional Chinese medicine ingredients by the lip skin, and enhance the effects of traditional Chinese medicine ingredients on the lip skin of nourishing yin, moisturizing, clearing heat and reducing swelling, hemostasis and lip care.
中药提取物配比根据中药方剂中各味中药比例进行调配中药提取物。中药方剂中，将里面组成药物分为君臣佐使，即君药、臣药、佐药、使药。“君”药是方剂中治疗主证，起主要作用的药物，按照需要，可用一味或几味。“臣”药是协助主药起治疗作用的药物。“佐”药是协助主药治疗兼证或抑制主药的毒性和峻烈的性味，或是反佐的药物。“使”药是引导各药直达疾病所在或有调和各药的作用。通过不同的中药配伍，形成不同的中药处方，起到不同的治疗效果。The proportion of traditional Chinese medicine extracts The traditional Chinese medicine extracts are prepared according to the proportions of various traditional Chinese medicines in the traditional Chinese medicine prescription. In traditional Chinese medicine prescriptions, the medicines in it are divided into monarch, minister and assistant, namely monarch medicine, minister medicine, adjuvant medicine, and envoy medicine. "Jun" medicine is the medicine that treats the main syndrome and plays a major role in the prescription. It can be used in one or several flavours as needed. "Chen" medicine is a medicine that assists the main medicine to play a therapeutic role. "Adjuvant" medicine is a medicine that assists the main medicine to treat the concurrent syndrome or suppresses the toxicity and strong taste of the main medicine, or is a counter-adjuvant medicine. "Making" medicine is to guide each medicine directly to the location of the disease or have the effect of reconciling each medicine. Through the compatibility of different traditional Chinese medicines, different traditional Chinese medicine prescriptions are formed, which have different therapeutic effects.
各原料主要功效：The main functions of each raw material:
女贞子：性平，味甘、苦，归肝、肾二经，有滋阴益寿、补益肝肾、清热明目、乌须黑 发等功效。一般常用于治疗头晕目眩、耳鸣目暗、腰膝酸痛、内热、须发早白等病症。《草本备要》中记载女贞子，“益肝肾，安五脏，强腰膝，明耳目，乌须发，补风虚，除百病”。《草本经疏》中载：“女贞子气味俱阴，正入肾除热补精之要品，肾得补，则五脏自安，精神自足，百病去而身肥健矣。”Ligustrum lucidum: flat in nature, sweet and bitter in taste, it belongs to the liver and kidney meridians, and has the functions of nourishing yin and longevity, nourishing liver and kidney, clearing heat and improving eyesight, black hair and black hair. It is generally used to treat dizziness, tinnitus, dark eyes, waist and knee pain, internal heat, premature graying of beard and hair and other symptoms. "Herbal Preparations" records Ligustrum lucidum, "benefits the liver and kidney, soothes the five internal organs, strengthens the waist and knees, improves the eyes and ears, black hair and hair, tonifies wind deficiency, and eliminates all diseases." "Herbal Classic Shu" contains: "Ligustrum lucidum has a yin smell, and it is an essential product for entering the kidney to remove heat and replenish the essence. If the kidney is replenished, the five internal organs will be at ease, the spirit will be self-sufficient, and the body will be fat and healthy after all diseases are gone."
旱莲草：性味归经：甘酸，凉。功效：凉血，止血，补肾，益阴。主治：治吐血，咳血，衄血，尿血，便血，血痢，刀伤出血，须发早白，白喉，淋浊、带下，阴部湿痒，老鼠痣。Eclipta: nature and flavor return to meridian: sweet and sour, cool. Efficacy: cooling blood, hemostasis, invigorating kidney, benefiting yin. Indications: Treatment of hematemesis, hemoptysis, epistaxis, hematuria, blood in the stool, blood dysentery, bleeding from knife wounds, premature whitening of hair and beard, diphtheria, stranguria, vaginal discharge, wet itching of the genitals, and mouse mole.
青蒿：具有清虚热，除骨蒸，解暑热，截疟，退黄之功效。常用于温邪伤阴，夜热早凉，阴虚发热，骨蒸劳热，暑邪发热，疟疾寒热，湿热黄疸等病症的治疗。Artemisia annua: It has the effects of clearing deficiency heat, removing bone steaming, relieving summer heat, cutting malaria, and relieving jaundice. It is often used in the treatment of diseases such as warm pathogens injuring yin, night heat and early coolness, yin deficiency fever, bone steaming labor fever, summer pathogenic fever, malaria cold and heat, damp-heat jaundice and other diseases.
金银花：性甘、寒；归肺、胃经。功效为清热解毒，消炎退肿。主治外感风热或温病发热，中暑，热毒血痢，痈肿疔疮，喉痹，多种感染性疾病。Honeysuckle: sweet and cold in nature; return to the lung and stomach meridians. The effect is to clear away heat and detoxify, reduce inflammation and reduce swelling. Indications are exogenous wind-heat or febrile disease fever, heat stroke, heat toxin blood dysentery, carbuncle swollen furuncle, throat paralysis, various infectious diseases.
蜂蜡：为蜜蜂科昆虫中华蜜蜂或意大利蜂分泌的蜡。将蜂巢置水中加热，滤过，冷凝取蜡或再精制而成。本品为不规则团块，大小不一。呈黄色、淡黄棕色或黄白色，不透明或微透明，表面光滑。体较轻，蜡质，断面砂粒状，用手搓捏能软化。有蜂蜜样香气，味微甘，归脾经。具有解毒、敛疮、生肌、止痛等功效，常用于溃疡、外伤、烧烫破溃、疮糜烂。Beeswax: The wax secreted by the honey bee insect, the Chinese honey bee or the Italian bee. The honeycomb is heated in water, filtered, condensed to get wax or refined again. This product is irregular lumps of different sizes. Yellow, yellowish-brown or yellowish-white, opaque or slightly transparent, smooth surface. The body is light, waxy, and the section is gritty, which can be softened by hand rubbing and kneading. It has a honey-like aroma, slightly sweet taste, and returns to the spleen meridian. It has the functions of detoxification, astringing sores, muscle regeneration, and pain relief.
橄榄油：属木本植物油，是由新鲜的油橄榄果实直接冷榨而成的，不经加热和化学处理，保留了天然营养成分，橄榄油被认为是迄今所发现的油脂中最适合人体营养的油脂。橄榄油富含与皮肤亲和力极佳的角鲨烯和人体必需脂肪酸，吸收迅速，有效保持皮肤弹性和润泽；橄榄油中所含丰富的单不饱和脂肪酸和维生素E、K、A、D等及酚类抗氧化物质，能消除面部皱纹，防止肌肤衰老，有护肤护发和防治手足皴裂等功效，有减少胃酸、阻止发生胃炎及十二指肠溃疡等病的功能；并可刺激胆汁分泌，激化胰酶的活力，使油脂降解，被肠黏膜吸收，以减少胆囊炎和胆结石的发生。还有润肠功能，长期食用可以有效缓解便秘。橄榄油成分中的叶绿素起新陈代谢作用，促进细胞生长，加速伤口愈合。实验表明，橄榄油含有的抗氧化剂可以消除体内自由基，恢复人体脏腑器官的健康状态，能防止脑衰老，并能延年益寿。Olive oil: It is a woody vegetable oil, which is directly cold-pressed from fresh olive fruit without heating and chemical treatment, and retains natural nutrients. Olive oil is considered to be the most suitable for human nutrition among the oils found so far. grease. Olive oil is rich in squalene and essential fatty acids that have excellent affinity with the skin, which is quickly absorbed and effectively maintains skin elasticity and moisture; olive oil is rich in monounsaturated fatty acids and vitamins E, K, A, D, etc. Phenolic antioxidants can eliminate facial wrinkles, prevent skin aging, have skin care and hair care and prevent and treat chapped hands and feet, reduce gastric acid, prevent gastritis and duodenal ulcers and other diseases; and stimulate bile secretion , to activate the activity of pancreatic enzymes, so that the lipids are degraded and absorbed by the intestinal mucosa, so as to reduce the occurrence of cholecystitis and gallstones. It also has the function of moistening the intestines, and long-term consumption can effectively relieve constipation. The chlorophyll in olive oil plays a role in metabolism, promotes cell growth and accelerates wound healing. Experiments have shown that the antioxidants contained in olive oil can eliminate free radicals in the body, restore the health of human organs, prevent brain aging, and prolong life.
维生素E：是一种脂溶性维生素，其水解产物为生育酚，是最主要的抗氧化剂之一，具有抗氧化的作用。可溶于脂肪和乙醇等有机溶剂中，不溶于水，对热、酸稳定，对碱不稳定，对氧敏感，对热不敏感。在临床上应用广泛。Vitamin E: It is a fat-soluble vitamin, and its hydrolysis product is tocopherol, which is one of the most important antioxidants and has an antioxidant effect. It is soluble in organic solvents such as fat and ethanol, insoluble in water, stable to heat and acid, unstable to alkali, sensitive to oxygen and insensitive to heat. It is widely used in clinical practice.
适用人群：亚健康状态肾阴虚、肝肾阴虚，容易出现嘴唇干燥开裂，或伴肿胀或出血，或伴眩晕耳鸣，咽干鼻燥，腰膝酸痛，月经量多等人群。Applicable people: People with sub-healthy kidney yin deficiency, liver and kidney yin deficiency, prone to dry and cracked lips, or accompanied by swelling or bleeding, or accompanied by dizziness, tinnitus, dry throat, dry nose, waist and knee pain, heavy menstrual flow, etc.
本发明相对于现有技术具有如下有益效果：The present invention has the following beneficial effects with respect to the prior art:
1.本发明中药唇膏与普通的唇膏相比，除了拥有润唇护唇功效，还拥有较好的治疗效果，具有滋阴清热的功效，是一种理想的唇部护理产品。1. Compared with the common lip balm, the traditional Chinese medicine lip balm of the present invention has a better therapeutic effect in addition to moisturizing the lips and protecting the lips, has the effect of nourishing yin and clearing away heat, and is an ideal lip care product.
2.本发明中药唇膏所用的功效成分女贞子提取物、旱莲草提取物、青蒿提取物、金银花提取物，均为天然植物来源，温和无刺激，安全性高。2. The functional components used in the traditional Chinese medicine lip balm of the present invention, Ligustrum lucidum extract, Eclipta chinensis extract, Artemisia annua extract, and Honeysuckle flower extract, are all natural plant sources, mild, non-irritating, and high in safety.
3.本发明中药唇膏在中药提取物中同时添加蜂蜡、橄榄油、维生素E油，合理配伍，发挥协同增效作用，具有长效保湿功效，可延长中药成分的作用时间，促进唇部皮肤对中药成分多的吸收利用，提升中药成分对唇部皮肤的滋阴保湿、清热消肿、止血护唇的功效。3. The traditional Chinese medicine lip balm of the present invention simultaneously adds beeswax, olive oil, and vitamin E oil to the traditional Chinese medicine extract, which is reasonably compatible, exerts a synergistic effect, has a long-term moisturizing effect, can prolong the action time of the traditional Chinese medicine ingredient, and promotes the skin on the lips. The absorption and utilization of many traditional Chinese medicine ingredients can improve the effect of traditional Chinese medicine ingredients on lip skin in nourishing yin, moisturizing, clearing heat and reducing swelling, hemostasis and lip protection.
4.本发明中药唇膏原料来源广泛，制作工艺简便，且成本低廉本，具有广泛的应用前景。4. The traditional Chinese medicine lip balm of the present invention has a wide range of raw materials, simple and convenient manufacturing process, low cost and wide application prospect.
下面将结合实施方式对本发明的实施方案进行详细描述，但是本领域技术人员将会理解，下列实施方式和实施例仅用于说明本发明，而不应视为限制本发明的范围。未注明具体条件者，按照常规条件或制造商建议的条件进行。所用试剂或仪器未注明生产厂商者，均为可以通过市售购买获得的常规产品。The embodiments of the present invention will be described in detail below in conjunction with the embodiments, but those skilled in the art will understand that the following embodiments and examples are only used to illustrate the present invention, and should not be regarded as limiting the scope of the present invention. If no specific conditions are specified, follow the general conditions or the conditions suggested by the manufacturer. The reagents or instruments used without the manufacturer's indication are conventional products that can be purchased from the market.
本发明实施方式提供的中药唇膏的配方中：In the formula of the traditional Chinese medicine lipstick provided by the embodiment of the present invention:
中药原料女贞子、墨旱莲、青蒿、金银花，均购于广州中医药大学第一附属医院。The raw materials of traditional Chinese medicine, Ligustrum lucidum, Eclipta chinensis, Artemisia annua, and honeysuckle, were purchased from the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine.
实施例1Example 1
一种具有滋阴清热功效的组合物制成的中药唇膏，由以下重量份数的原料制备而成：中药提取物6份、蜂蜡10份、橄榄油30份、维生素E油5份。在实际应用中，可适量增加食用色粉调配不同颜色，不影响功效。中药提取物包括女贞子提取物、墨旱莲提取物、青蒿提取物、金银花提取物，按以下重量份数的原料制备而成：女贞子提取物20份、墨旱莲提取物20份、青蒿提取物10份、金银花提取物10份。具体制备步骤如下：A traditional Chinese medicine lip balm made of a composition with the functions of nourishing yin and clearing heat is prepared from the following raw materials by weight: 6 parts of traditional Chinese medicine extracts, 10 parts of beeswax, 30 parts of olive oil and 5 parts of vitamin E oil. In practical application, appropriate amount of edible toner can be added to mix different colors without affecting the efficacy. The traditional Chinese medicine extracts include Ligustrum lucidum extract, Eclipta japonica extract, Artemisia annua extract, and honeysuckle extract, and are prepared from the following raw materials by weight: 20 parts of Ligustrum lucidum extract, 20 parts of Eclipta japonica extract 10 parts of Artemisia annua extract, 10 parts of honeysuckle extract. The specific preparation steps are as follows:
(1)制备中药提取物：(1) Preparation of traditional Chinese medicine extracts:
①女贞子粉碎，过50目筛；墨旱莲、青蒿、金银花粉碎，过60目筛。① Crushed Ligustrum lucidum and passed through a 50-mesh sieve; Pulverized Eclipta, Artemisia annua, and honeysuckle, passed through a 60-mesh sieve.
②仪器装置：硬质圆底烧瓶，上接挥发油测定器，挥发油测定器的上端连接回流冷凝管。以上各部均用玻璃磨口连接。全部仪器充分洗净，并检查接合部分保证严密，以防挥发油逸出。②Instrument device: a hard round-bottomed flask, connected with a volatile oil measuring device, and the upper end of the volatile oil measuring device is connected with a reflux condenser. All the above parts are connected with glass grinding mouth. All instruments are fully cleaned, and the joints are checked to ensure tightness to prevent volatile oil from escaping.
③提取及测定方法：采用中国药典2015年版四部通则“2204挥发油测定法”下甲法提取测定。将中药放入圆底烧瓶中，浸泡5小时。连接挥发油测定器与回流冷凝管，自冷凝管上端加水使充满挥发油测定器的刻度部分，并溢流入烧瓶时为止。打开加热仪器，使其加热至沸腾后，降低加热温度，使其保持微沸状态，持续约5小时，至测定器中油量不再增加，停止加热。放置片刻，开启测定器下端的活塞，将水缓缓放出，至油层上端到达刻度0线上面5mm处为止。放置1小时以上，再开启活塞使油层下降至其上端恰与刻度0线平齐，读取挥发油量，并计算供试品中挥发油的含量(％)。挥发油得率的计算公式为：得油率(％)＝(油提 物重量)/(样品重量)×100％。然后将精油仔细分离放入玻璃瓶，置于4℃冰箱中保存。③Extraction and determination methods: Extraction and determination under the first method of "2204 Volatile Oil Determination Method" of the 2015 edition of the Chinese Pharmacopoeia. Put the traditional Chinese medicine in a round-bottomed flask and soak for 5 hours. Connect the volatile oil measuring device and the reflux condenser, add water from the upper end of the condenser to fill the scale part of the volatile oil measuring device and overflow into the flask. Turn on the heating instrument and make it heated to boiling, then lower the heating temperature to keep it in a slightly boiling state for about 5 hours, until the amount of oil in the measuring device no longer increases, stop heating. Leave it for a while, open the piston at the lower end of the measuring device, and slowly release the water until the upper end of the oil layer reaches 5mm above the 0 line of the scale. Leave it for more than 1 hour, then turn on the piston to make the oil layer drop to the level of the 0 line on the upper end of the scale, read the amount of volatile oil, and calculate the content (%) of volatile oil in the test sample. The calculation formula of the volatile oil yield is: oil yield (%)=(weight of oil extract)/(weight of sample)×100%. Then the essential oils were carefully separated into glass bottles and stored in a 4°C refrigerator.
女贞子：女贞子粉末称取70g，提取前，置硬质圆底烧瓶中，加入1L无菌蒸馏水，浸泡5小时。于挥发油测定器上端加入约3mL正己烷，回流提取5小时，静置，补足正己烷至体积为3mL。取正己烷层，加入无水硫酸钠干燥静置过夜，取上清液，过0.22μm微孔滤膜，备用。Ligustrum lucidum: Weigh 70 g of Ligustrum lucidum powder, put it in a hard round-bottomed flask, add 1 L of sterile distilled water, and soak for 5 hours before extraction. About 3 mL of n-hexane was added to the upper end of the volatile oil measuring device, refluxed for extraction for 5 hours, allowed to stand, and the volume of n-hexane was supplemented to 3 mL. The n-hexane layer was taken, dried by adding anhydrous sodium sulfate and left to stand overnight. The supernatant was taken and passed through a 0.22 μm microporous membrane for use.
墨旱莲、青蒿、金银花：粉碎后的墨旱莲、青蒿、金银花粉末均称取60g，置硬质圆底烧瓶中，加入500mL无菌蒸馏水，浸泡5小时。回流提取5小时，正己烷定容至2mL(挥发油提取器的收集管中加约1mL正己烷)。取正己烷层，加入无水硫酸钠干燥静置过夜，取上清液，过0.22μm微孔滤膜，备用。Eclipta japonica, Artemisia annua, and honeysuckle: Weigh 60 g of the pulverized Eclipta japonica, Artemisia annua, and honeysuckle powder, put them in a hard round-bottomed flask, add 500 mL of sterile distilled water, and soak for 5 hours. After reflux extraction for 5 hours, the volume of n-hexane was adjusted to 2 mL (about 1 mL of n-hexane was added to the collection tube of the volatile oil extractor). The n-hexane layer was taken, dried by adding anhydrous sodium sulfate and left to stand overnight. The supernatant was taken and passed through a 0.22 μm microporous membrane for use.
(2)原料混合：(2) Raw material mixing:
①取无菌容器，称量配方量的蜂蜡和橄榄油；① Take a sterile container, and weigh the formula amount of beeswax and olive oil;
②加热至80℃，融化成液体，充分振动摇匀；② Heat to 80℃, melt into liquid, shake well and shake well;
③依次加入配方量的维生素E油，实施例1制备的中药提取物，充分振动摇匀后倒入模具；3. add the vitamin E oil of the formula quantity successively, the Chinese medicine extract prepared in Example 1, and pour into the mould after fully vibrating and shaking up;
④待冷却后出模。④Exit the mold after cooling.
实施例2-10Examples 2-10
参照实施例1的方法制备，其区别仅在于各原材料的用量不同，原材料份数用量如下表1、表2所示：With reference to the method preparation of Example 1, the difference is only in that the consumption of each raw material is different, and the amount of raw material parts is shown in Table 1 and Table 2 below:
表1中药提取物、蜂蜡、橄榄油和维生素E油的重量份数用量Table 1 The dosage of Chinese medicine extract, beeswax, olive oil and vitamin E oil in parts by weight
| 中药提取物Chinese herbal extract | 蜂蜡beeswax | 橄榄油olive oil | 维生素E油Vitamin E oil | |
| 实施例2Example 2 | 66 | 1515 | 3030 | 55 |
| 实施例3Example 3 | 99 | 2020 | 4040 | 55 |
| 实施例4Example 4 | 66 | 2020 | 4040 | 55 |
| 实施例5Example 5 | 66 | 1010 | 2020 | 55 |
| 实施例6Example 6 | 66 | 1010 | 3030 | 1010 |
| 实施例7Example 7 | 99 | 1010 | 3030 | 1010 |
| 实施例8Example 8 | 66 | 1010 | 3030 | 55 |
| 实施例9Example 9 | 99 | 1010 | 3030 | 55 |
| 实施例10Example 10 | 99 | 1515 | 3030 | 55 |
表2中药提取物中各原料的重量份数用量The parts by weight dosage of each raw material in table 2 Chinese medicine extract
| 女贞子提取物Ligustrum lucidum extract | 墨旱莲提取物Echinacea Extract | 青蒿提取物Artemisia annua extract | 金银花提取物Honeysuckle Extract | |
| 实施例2Example 2 | 2020 | 2020 | 2020 | 1010 |
| 实施例3Example 3 | 2020 | 2020 | 1010 | 2020 |
| 实施例4Example 4 | 2020 | 2020 | 2020 | 2020 |
| 实施例5Example 5 | 2020 | 2020 | 55 | 55 |
| 实施例6Example 6 | 2020 | 1010 | 1010 | 1010 |
| 实施例7Example 7 | 2020 | 3030 | 1010 | 1010 |
| 实施例8Example 8 | 1010 | 2020 | 1010 | 1010 |
| 实施例9Example 9 | 1010 | 1010 | 2020 | 2020 |
| 实施例10Example 10 | 55 | 55 | 2020 | 2020 |
对比例1：Comparative Example 1:
对比例1与实施例1不同的是，省去橄榄油，调整蜂蜡为40份，其他操作同实施例1。The difference between Comparative Example 1 and Example 1 is that olive oil was omitted, and the amount of beeswax was adjusted to 40 parts, and other operations were the same as those of Example 1.
对比例2：Comparative Example 2:
对比例2与实施例1不同的是，省去中药提取物，其他操作同实施例1。The difference between Comparative Example 2 and Example 1 is that the traditional Chinese medicine extract is omitted, and other operations are the same as those of Example 1.
对比例3：Comparative Example 3:
对比例3与实施例1不同的是，省去维生素E油，其他操作同实施例1。The difference between Comparative Example 3 and Example 1 is that vitamin E oil is omitted, and other operations are the same as those of Example 1.
效果实施例1Effect Example 1
检测实施例2制备的中药唇膏的保湿性能。The moisturizing performance of the traditional Chinese medicine lipstick prepared in Example 2 was tested.
(1)实验方法：选用年龄18-40岁，40名女性志愿者，分为4组，每组10人，以组为单位，一一对应分别在唇部均匀涂抹实施例1、对比例1-3制备的产品，使用皮肤检测仪(Real Bubee，RBX-916)测定使用前、使用后20分钟、使用后2小时和使用后4小时的唇部水分含量，统计每组志愿者皮肤水分含量，计算平均值。结果如表3所示。(1) Experimental method: 40 female volunteers aged 18-40 years old were selected and divided into 4 groups, 10 people in each group. The group was taken as a unit, and they were applied to the lips one by one. Example 1 and Comparative Example 1 -3 For the prepared product, use a skin detector (Real Bubee, RBX-916) to measure the lip moisture content before use, 20 minutes after use, 2 hours after use and 4 hours after use, and count the skin moisture content of each group of volunteers , calculate the average. The results are shown in Table 3.
(2)结果分析：在保湿性能方面表现为实施例1优于对比例1-3，对比例3优于对比例2，对比例2优于对比例1。其中对比例1仅在使用15分钟后表现出显著的保湿作用，随后保湿作用不佳。对比例2与对比例3相对实施例1保湿较差。由此可见，本产品将中药提取物与蜂蜡、橄榄油和维生素E油结合，相互之间发挥协同增效作用，提升产品长效保湿性能，能促进皮肤在时间内利用中药有效成分，提升滋阴保湿的作用。(2) Result analysis: in terms of moisturizing performance, Example 1 is better than Comparative Examples 1-3, Comparative Example 3 is better than Comparative Example 2, and Comparative Example 2 is better than Comparative Example 1. Among them, Comparative Example 1 showed a significant moisturizing effect only after 15 minutes of use, and then the moisturizing effect was poor. Comparative Example 2 and Comparative Example 3 are less moisturizing than Example 1. It can be seen that this product combines Chinese herbal extracts with beeswax, olive oil and vitamin E oil, which play a synergistic effect with each other, improve the long-term moisturizing performance of the product, and can promote the skin to utilize the active ingredients of Chinese herbal medicine in a short time, improve the moisturizing effect. Yin moisturizing effect.
表3唇部水分含量Table 3 Moisture content of lips
| 使用前before use | 使用后20分钟20 minutes after use | 使用后2小时2 hours after use | 使用后4小时4 hours after use | |
| 实施例1Example 1 | 20％20% | 58％58% | 54％54% | 51％51% |
| 对比例1Comparative Example 1 | 22％twenty two% | 50％50% | 40％40% | 32％32% |
| 对比例2Comparative Example 2 | 21％twenty one% | 58％58% | 48％48% | 40％40% |
| 对比例3Comparative Example 3 | 20％20% | 56％56% | 50％50% | 45％45% |
效果实施例2Effect Example 2
评价中药提取物实施例2-10制备的制备的中药唇膏的滋阴清热功效。The effect of nourishing yin and clearing away heat of the prepared traditional Chinese medicine lip balm prepared by the traditional Chinese medicine extract Examples 2-10 was evaluated.
(1)实验方法：选取符合亚健康状态肾阴虚证中医辨证评定标准，兼有嘴唇干裂，或伴有出血、轻微肿胀者，年龄18-60岁，78名志愿者，分为12组，每组6人，以组为单位，一一对应分别在唇部均匀涂抹实施例1-10、对比例1-3制备的产品，连续使用2周，每天涂抹2次，至少维持2小时。根据自拟中医症状评定表，评定使用前、使用后一周的症状评分，分为无效、有效、显效。(1) Experimental method: 78 volunteers, aged 18-60 years old, were selected and divided into 12 groups, who met the criteria for TCM syndrome differentiation evaluation of kidney-yin deficiency syndrome in sub-health state, and had chapped lips, or accompanied by bleeding and slight swelling. Each group of 6 people, taking the group as a unit, evenly applied the products prepared in Examples 1-10 and Comparative Examples 1-3 on the lips one-to-one, for 2 weeks, smeared twice a day, and maintained for at least 2 hours. According to the self-made TCM symptom evaluation table, the symptom scores before and one week after use were evaluated and divided into ineffective, effective and markedly effective.
1)纳入标准：符合亚健康状态肾阴虚证中医辨证评定标准
[1-2]：①肾虚证表现主要为腰背酸痛、腿膝酸软、疲倦乏力、耳鸣、脱发等；②阴液亏虚表现主要为嘴唇干燥或伴出血、眼涩、咽干、大便干结等③阴虚火旺，热扰心神等表现主要为盗汗、手心发热、失眠多梦等④亚健康状态肾阴虚证的舌脉以舌红、脉沉细为主；⑤根据自拟《中医症状评定表》评分达8分以上者。
1) Inclusion criteria: In accordance with the TCM syndrome differentiation evaluation criteria of kidney-yin deficiency syndrome in sub-health state [1-2] : ①Shenzhen kidney deficiency syndrome is mainly manifested by low back pain, weak legs and knees, fatigue, tinnitus, hair loss, etc.; ②Yin fluid deficiency The main manifestations are dry lips or accompanied by bleeding, astringent eyes, dry throat, dry stool, etc. ③ Yin deficiency and fire, heat disturbing the mind, etc. The manifestations are mainly night sweats, palm fever, insomnia and dreaming, etc. ④ Sub-healthy tongue and pulse of kidney yin deficiency syndrome Mainly with red tongue and thin pulse;
2)排除标准：患有重大疾病、传染病或具有凝血功能障碍者；患有精神疾病及重大躯体疾病；丧失或不具备自主判断能力的患者。2) Exclusion criteria: patients with major diseases, infectious diseases or coagulation disorders; patients with mental illness and major physical diseases; patients who have lost or do not have the ability to make independent judgments.
3)《中医症状评定表》如表4所示：3) "Traditional Chinese Medicine Symptom Evaluation Table" is shown in Table 4:
表4评定表Table 4 Evaluation Form
4)中医疗效判定标准：4) Criteria for judging the efficacy of traditional Chinese medicine:
显效：中医临床症状、体征明显改善，证候积分减少≥70％；Significantly effective: TCM clinical symptoms and signs are significantly improved, and syndrome scores are reduced by ≥70%;
有效：中医临床症状、体征均有好转，证候积分减少≥30％；Effective: TCM clinical symptoms and signs have improved, and syndrome scores have been reduced by ≥30%;
无效：中医临床症状、体征均无明显改善，甚或加重，证候积分减少不足30％。Invalid: TCM clinical symptoms and signs were not significantly improved, or even worsened, and the syndrome score was reduced by less than 30%.
显效、有效计入总有效。Significantly effective and effective are included in the total effective.
5)结果：在中医疗效判定中，实施例1-10的总有效率在83％以上，其中实施例1、实施例3、实施例9效果更明显，对亚健康状态肾阴虚证有一定的疗效。对比例1-3总有效率在17-33％之间优于对比例1-3，对比例1与对比例2均优于对比例2(见表5)，其中对比例2成分中无中药提取物。由此可见，本产品将中药提取物与蜂蜡、橄榄油和维生素E油结合，相互之间发挥协同增效作用，提升产品滋阴清热功效性能，能促进皮肤在时间内利用中药有效成分，提升滋阴保湿的作用。5) Result: in the evaluation of the efficacy of traditional Chinese medicine, the total effective rate of Examples 1-10 is more than 83%, and the effect of Example 1, Example 3, and Example 9 is more obvious, and has a certain effect on the sub-health state of kidney-yin deficiency syndrome. Efficacy. The total effective rate of comparative example 1-3 is between 17-33%, which is better than that of comparative example 1-3, and both comparative example 1 and comparative example 2 are better than comparative example 2 (see Table 5), and there is no traditional Chinese medicine in the composition of comparative example 2. Extract. It can be seen that this product combines Chinese herbal extracts with beeswax, olive oil and vitamin E oil, which play a synergistic effect with each other, improve the product's yin-nourishing and heat-clearing performance, and can promote the skin to utilize the active ingredients of traditional Chinese medicines within a time. Nourishing and moisturizing effect.
表5评定结果Table 5 Evaluation Results
| 无效(例)invalid (example) | 有效(例)Valid (example) | 显效(例)Effective (example) | 总有效率(％)Total Efficiency (%) | |
| 实施例1Example 1 | 00 | 22 | 44 | 100％100% |
| 实施例2Example 2 | 11 | 22 | 33 | 83％83% |
| 实施例3Example 3 | 00 | 33 | 33 | 100％100% |
| 实施例4Example 4 | 11 | 22 | 33 | 83％83% |
| 实施例5Example 5 | 11 | 55 | 00 | 83％83% |
| 实施例6Example 6 | 11 | 22 | 33 | 83％83% |
| 实施例7Example 7 | 11 | 44 | 11 | 83％83% |
| 实施例8Example 8 | 11 | 33 | 22 | 83％83% |
| 实施例9Example 9 | 00 | 22 | 44 | 100％100% |
| 实施例10Example 10 | 11 | 44 | 11 | 83％83% |
| 对比例1Comparative Example 1 | 44 | 22 | 00 | 33％33% |
| 对比例2Comparative Example 2 | 55 | 11 | 00 | 17％17% |
| 对比例3Comparative Example 3 | 44 | 22 | 00 | 33％33% |
6)参考文献：6) References:
[1]黄诚,宋炜熙.问卷与量表在中医证候辨证中的研究与应用[J].中华中医药学 刊,2011,29(04):889-891.[1] Huang Cheng, Song Weixi. Research and application of questionnaires and scales in TCM syndrome differentiation [J]. Chinese Journal of Chinese Medicine, 2011, 29(04): 889-891.
[2]王学良,李赛美,赵晓山,等.亚健康状态肾阴虚证的证候特征[J].广东医学,2009,30(1):117-119.[2] Wang Xueliang, Li Saimei, Zhao Xiaoshan, et al. Syndrome characteristics of kidney yin deficiency in sub-health state [J]. Guangdong Medicine, 2009, 30(1): 117-119.
效果实施例3Effect Example 3
通过动物毒性实验检测实施例1制备的护肤品的毒性作用。Toxic effects of the skin care products prepared in Example 1 were detected by animal toxicity experiments.
实验方法：experimental method:
(1)动物：BALB/c小鼠(市售)，雄性16只，体质量18～22g，饲养于SPF级环境。(1) Animals: BALB/c mice (commercially available), 16 males, weighing 18-22 g, were raised in an SPF environment.
(2)试剂：具有滋阴清热功效的组合物(2) Reagent: composition with the effect of nourishing yin and clearing away heat
(3)模型的制备及处理：将16只雄性BALB/c小鼠饲养于SPF级环境，分为对照组8只，实验组(实施例1)8只。实验时，使用剃毛刀将小鼠背部的毛发刮去，面积约为3cm*3cm。实验组小鼠每天使用中药唇膏膏体外涂于背部脱毛处，对照组小鼠背部以同量及同种方式涂抹凡士林软膏进行对照，每天1次，连续涂抹一周。(3) Model preparation and treatment: 16 male BALB/c mice were raised in an SPF environment and divided into 8 mice in the control group and 8 mice in the experimental group (Example 1). During the experiment, the hair on the back of the mice was shaved with a razor, with an area of about 3cm*3cm. The mice in the experimental group were smeared with traditional Chinese medicine lip balm on the back depilation area every day, while the mice in the control group were smeared with Vaseline ointment in the same amount and in the same way, once a day, for a week.
(4)结果：采用三人背靠背评分模式，根据《小鼠背部皮肤及精神状况观察量表》(表6)评分标准进行判定，对小鼠背部皮肤进行观察。实验可知，使用中药唇膏膏体涂抹一周后，实验组小鼠未见皮肤干燥、粗糙、增厚、红肿等异常情况，亦无小鼠躁动不安或萎靡不振等异常行为。(4) Results: The three-person back-to-back scoring mode was used, and the back skin of the mice was observed according to the scoring standard of the "Observation Scale for Skin and Mental Condition on the Back of Mice" (Table 6). The experiment showed that after applying the traditional Chinese medicine lipstick paste for one week, the mice in the experimental group did not have abnormal skin dryness, roughness, thickening, redness and swelling, and no abnormal behaviors such as restlessness or malaise.
表6《小鼠背部皮肤及精神状况观察量表》Table 6 "Observation Scale of Mice Back Skin and Mental Condition"
效果实施例4Effect Example 4
通过细胞活性试验检测女贞子提取物(精油)、墨旱莲提取物(精油)、青蒿提取物(精油)和金银花提取物(精油)的毒性作用。The toxicity of Ligustrum lucidum extract (essential oil), Eclipta japonica extract (essential oil), Artemisia annua extract (essential oil) and honeysuckle extract (essential oil) were detected by cell viability test.
实验方法：experimental method:
(1)细胞来源：选取人角质细胞(Hacat，购自碧云天，产品型号C6282)(1) Cell source: select human keratinocytes (Hacat, purchased from Biyuntian, product model C6282)
(2)主要试剂：DMEM/F12(Gibco)、胎牛血清(FBS)(Gibco)、双抗(Gibco)、DMSO(Vetec)、MTT(Sigma)、PBS、胰蛋白酶(sigma)、女贞子提取物(精油)、墨旱莲提取物(精油)、青蒿提取物(精油)和金银花提取物(精油)等。(2) Main reagents: DMEM/F12 (Gibco), fetal bovine serum (FBS) (Gibco), double antibody (Gibco), DMSO (Vetec), MTT (Sigma), PBS, trypsin (sigma), Ligustrum lucidum Extract (essential oil), Eclipta chinensis extract (essential oil), Artemisia annua extract (essential oil) and honeysuckle extract (essential oil) etc.
(3)精油溶液的配制：精油经过0.22μm微孔滤膜过滤除菌，取10μL加入9990μL含1％(V/V)DMSO的培养基中，涡旋混匀，即得0.1％(V/V)精油贮存液，使用时稀释到设定工作浓度，现配现用。(3) Preparation of essential oil solution: The essential oil was filtered and sterilized through a 0.22 μm microporous membrane, and 10 μL was added to 9990 μL of medium containing 1% (V/V) DMSO, and vortexed and mixed to obtain 0.1% (V/V) V) Essential oil storage solution, diluted to the set working concentration when used, ready to use.
(4)主要仪器(4) Main instruments
细胞培养箱(HERACELL 150i)；超净工作台(HFsafe-1200LC)；显微镜(Nikon eclicse TS100-F)；酶标仪(Spectra Max M2)；离心机(SIGMA 3K15)；细胞计数板(浙江玉环求精医用仪器厂)。Cell incubator (HERACELL 150i); ultra-clean workbench (HFsafe-1200LC); microscope (Nikon eclicse TS100-F); microplate reader (Spectra Max M2); centrifuge (SIGMA 3K15); Fine Medical Instrument Factory).
(5)细胞活性试验(MTT法检测细胞活性试验)(5) Cell viability test (MTT assay for cell viability test)
收集细胞，细胞计数板计数，细胞调整至4×10
4个/ml后接种于96孔板，培养24h后备用。培养液中加入1％DMSO作为增溶剂。收集细胞，细胞计数板计数，细胞调整至4×10
4个/ml后接种于96孔板，培养24h后备用。配制含0.01％～0.09％(V/V)女贞子提取物(精油)、墨旱莲提取物(精油)、青蒿提取物(精油)和金银花提取物(精油)的培养液孵育细胞24h，弃去培养液，PBS清洗细胞后，加入5mg/mL MTT，孵育4h后终止，弃去培养液。各孔加100uL DMSO，避光缓慢振荡10min，立即测定490nm处各孔OD值，每个计量3个平行，计算其OD值平均值。
Cells were collected, counted on a cell counter, adjusted to 4×10 4 cells/ml, inoculated into a 96-well plate, and cultured for 24 hours for later use. 1% DMSO was added to the culture medium as a solubilizer. Cells were collected, counted on a cell counter, adjusted to 4×10 4 cells/ml, inoculated into a 96-well plate, and cultured for 24 hours for later use. Prepare a culture solution containing 0.01%-0.09% (V/V) Ligustrum lucidum extract (essential oil), Eclipta japonica extract (essential oil), Artemisia annua extract (essential oil) and honeysuckle extract (essential oil) and incubate the cells for 24h , discard the culture medium, after washing the cells with PBS, add 5 mg/mL MTT, incubate for 4 h to terminate, and discard the culture medium. Add 100 uL DMSO to each well, shake slowly for 10 min in the dark, and immediately measure the OD value of each well at 490 nm, with 3 parallel measurements for each, and calculate the average value of the OD value.
(5)结果表明：使用女贞子、墨旱莲、青蒿和金银花提取物后细胞存活率均达80％以上，表明女贞子、墨旱莲、青蒿和金银花提取物无明显细胞毒性。(5) The results showed that the cell survival rate was over 80% after using the extracts of Ligustrum lucidum, Ecclusa, Artemisia annua and honeysuckle, indicating that the extracts of Ligustrum lucidum, Eclipta, Artemisia annua and honeysuckle had no obvious cytotoxicity. .
上述实施例为本发明较佳的实施方式，但本发明的实施方式并不受上述实施例的限制，其他的任何未背离本发明的精神实质与原理下所作的改变、修饰、替代、组合、简化，均应为等效的置换方式，都包含在本发明的保护范围之内。The above-mentioned embodiments are preferred embodiments of the present invention, but the embodiments of the present invention are not limited by the above-mentioned embodiments, and any other changes, modifications, substitutions, combinations, The simplification should be equivalent replacement manners, which are all included in the protection scope of the present invention.
Claims (10)
- 一种具有滋阴清热功效的中药唇膏，其特征在于：包括以下按重量份数计的原料：中药提取物5～10份、蜂蜡10～20份、橄榄油20～40份、维生素E油5～10份；其中，所述中药提取物由以下按重量份数计的原料制备而成：女贞子提取物5～20份、墨旱莲提取物5～20份、青蒿提取物5～20份、金银花提取物5～20份。A traditional Chinese medicine lip balm with the effect of nourishing yin and clearing away heat, characterized in that it comprises the following raw materials in parts by weight: 5-10 parts of traditional Chinese medicine extract, 10-20 parts of beeswax, 20-40 parts of olive oil, and 5 parts of vitamin E oil. ～10 parts; wherein, the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 5-20 parts of Ligustrum lucidum extract, 5-20 parts of Eclipta chinensis extract, 5-20 parts of Artemisia annua extract 20 parts, 5-20 parts of honeysuckle extract.
- 根据权利要求1所述的具有滋阴清热功效的中药唇膏，其特征在于：The traditional Chinese medicine lip balm with nourishing yin and heat-clearing effect according to claim 1, is characterized in that:所述中药唇膏包括以下按重量份数计的原料：中药提取物6份、蜂蜡10份、橄榄油30份、维生素E油5份。The traditional Chinese medicine lip balm includes the following raw materials in parts by weight: 6 parts of traditional Chinese medicine extracts, 10 parts of beeswax, 30 parts of olive oil, and 5 parts of vitamin E oil.
- 根据权利要求1或2所述的具有滋阴清热功效的中药唇膏，其特征在于：The traditional Chinese medicine lipstick with nourishing yin and heat-clearing effect according to claim 1 and 2, is characterized in that:所述中药提取物由以下按重量份数计的原料制备而成：女贞子提取物20份、墨旱莲提取物20份、青蒿提取物10份、金银花提取物10份。The traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 20 parts of Ligustrum lucidum extract, 20 parts of Eclipta chinensis extract, 10 parts of Artemisia annua extract, and 10 parts of honeysuckle extract.
- 根据权利要求1或2所述的具有滋阴清热功效的中药唇膏，其特征在于：The traditional Chinese medicine lipstick with nourishing yin and heat-clearing effect according to claim 1 and 2, is characterized in that:所述的原料还包括可食用色粉、香精和花蜡中的至少一种。The raw material also includes at least one of edible color powder, essence and flower wax.
- 根据权利要求1或2所述的具有滋阴清热功效的中药唇膏，其特征在于：The traditional Chinese medicine lipstick with nourishing yin and heat-clearing effect according to claim 1 and 2, is characterized in that:所述的原料还包括按重量份数计的可食用色粉0.5～5份、香精0.5～5份和花蜡5～20份。The raw materials also include 0.5-5 parts by weight of edible toner, 0.5-5 parts of essence and 5-20 parts of flower wax.
- 权利要求1～5任一项所述的具有滋阴清热功效的中药唇膏的制备方法，其特征在于：包括以下步骤：The preparation method of the traditional Chinese medicine lipstick with the effect of nourishing yin and clearing away heat according to any one of claims 1 to 5, characterized in that: comprising the following steps:S1、将各种中药原料分别粉碎，过筛，得到各种中药原料的粉末；S1, pulverize and sieve various traditional Chinese medicine raw materials respectively to obtain the powder of various traditional Chinese medicine raw materials;S2、分别取各种中药原料的粉末，加水，浸泡，用水蒸气蒸馏法提取挥发油，提取液经干燥，过滤，即得到各种中药原料的提取物；S2, respectively take the powder of various traditional Chinese medicine raw materials, add water, soak, extract volatile oil by steam distillation, and the extract is dried and filtered to obtain the extracts of various traditional Chinese medicine raw materials;S3、将蜂蜡和橄榄油混合，加热至融化，摇匀；依次加入维生素E油，步骤S1制备的各种中药原料的提取物，摇匀；将所得混合物倒膜，待冷却凝固，即获得所述润唇膏；当原料中包括可食用色粉时，将蜂蜡和橄榄油混合，加热至融化，摇匀；先加入维生素E油，摇匀；然后加入可食用色粉，摇匀；最后再加入各种中药原料的提取物，摇匀；将所得混合物倒膜，待冷却凝固，即获得所述中药唇膏。S3, mix beeswax and olive oil, heat until melted, and shake well; add vitamin E oil in turn, the extracts of various traditional Chinese medicine raw materials prepared in step S1, and shake well; pour the resulting mixture into a film, and wait for cooling to solidify to obtain the obtained lip balm; when the raw material includes edible toner, mix beeswax and olive oil, heat until melted, and shake well; first add vitamin E oil, shake well; then add edible toner, shake well; finally add The extracts of various traditional Chinese medicine raw materials are shaken well; the obtained mixture is poured into a film, and the traditional Chinese medicine lip balm is obtained after cooling and solidification.
- 根据权利要求6所述的具有滋阴清热功效的中药唇膏的制备方法，其特征在于：The preparation method of the traditional Chinese medicine lipstick with nourishing yin and heat-clearing effect according to claim 6, is characterized in that:所述的步骤S3中，加热的温度为70～90℃。In the step S3, the heating temperature is 70-90°C.
- 根据权利要求6所述的具有滋阴清热功效的中药唇膏的制备方法，其特征在于：The preparation method of the traditional Chinese medicine lipstick with nourishing yin and heat-clearing effect according to claim 6, is characterized in that:所述的步骤S2中，当中药原料为女贞子时，水的重量为药材重量的10～16倍，浸泡的时间为4～6小时；当中药原料为墨旱莲、青蒿或金银花时，水的重量为药材重量的6～10倍，浸泡的时间为4～6小时。In the described step S2, when the traditional Chinese medicine raw material is Ligustrum lucidum, the weight of water is 10 to 16 times the weight of the medicinal material, and the soaking time is 4 to 6 hours; , the weight of water is 6 to 10 times the weight of the medicinal material, and the soaking time is 4 to 6 hours.
- 根据权利要求6所述的具有滋阴清热功效的中药唇膏的制备方法，其特征在于：The preparation method of the traditional Chinese medicine lipstick with nourishing yin and heat-clearing effect according to claim 6, is characterized in that:所述的步骤S2中，水蒸气蒸馏法按《中国药典》2015版“2204挥发油测定法”进行。In the described step S2, the steam distillation method is carried out according to the "2204 Volatile Oil Determination Method" of "Chinese Pharmacopoeia" 2015 edition.
- 根据权利要求6所述的具有滋阴清热功效的中药唇膏的制备方法，其特征在于：The preparation method of the traditional Chinese medicine lipstick with nourishing yin and heat-clearing effect according to claim 6, is characterized in that:所述的步骤S1中，过筛为过50～60目筛；In the described step S1, sieving is to pass through a 50-60 mesh sieve;所述的步骤S2中，水为无菌蒸馏水；In the described step S2, the water is sterile distilled water;所述的步骤S2中，干燥所用的试剂为无水硫酸钠。In the step S2, the reagent used for drying is anhydrous sodium sulfate.所述的步骤S2中，过滤所用的微孔滤膜的孔径为0.22μm。In the step S2, the pore size of the microporous membrane used for filtration is 0.22 μm.
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