CN107737058B - - 1 gold moisture retention water of a kind of biological carbohydrate gum and preparation method thereof - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A61Q19/00—Preparations for care of the skin
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61K2800/75—Anti-irritant
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
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Abstract
The present invention relates to a kind of toners, are more particularly to a kind of efficient moisture-retention toner containing gold.Gold moisture retention water provided by the invention includes following components in parts by weight: 0.1-1 parts of thickener, 0.1-10 parts of plant amino acid moisturizer, 0.001-0.5 parts of natural moisturizing factor, 5-20 parts of moisturizer, 0.1-10 parts of skin conditioning agent, 0.01-0.05 parts of chelating agent, special additive/0.14-2.8 parts of colorant, 0.001-0.01 parts of essence, 0.01-0.1 parts of solubilizer, 0.01-0.5 parts of preservative, deionized water is mended to 100 parts.Gold moisture retention water provided by the invention, perfect in shape and function, while efficient moisturizing, also have releive, repair, skin lightening, U.S. flesh and the anti-inflammatory, anti-radiation effect such as compact.
Description
Technical field
The present invention relates to a kind of toners, are more particularly to a kind of efficient moisture-retention toner containing gold.
Background technique
Water is an important factor for skin maintains normal function.For example, hydrolase is the key component for making dead skin cells furfur,
Its activity depends on the sufficient degree of moisture.Moisture keeps skin emolliency healthy, if the outermost water content of stratum corneum of skin is less than
10%, skin will become dry sensitive.Water energy of making up supplement and the moisture for maintaining chicken keratoderma, keep cuticula soft,
The normal function of cuticula is kept, and there is the effect for neutralizing soda acid, the ingredient without generation blocked pore, greasy skin,
Also without drawing moisture in skin the shortcomings that, therefore the deep favor by people.Toner has several of the types: moisture retention water, skin toner
Water, astringent lotion, smoothing toner etc., humidity-preserving type toner are most common one kind in toner, and being most suitable for drying type skin crowd makes
With the skin being especially chronically at when air-conditioning, solarization.
The basic maintenance of skin is generally divided into cleaning, activity, moisturizing three categories, need to pass through the Fouling Cleaning of Cleaning mop skin
Completely, then by beautifying liquid etc. skin activity is assigned, and moisturizing be then as human body need to take in vegetables meat extra-nutrition daily,
It is essential.At present about the existing many reports of the research of humidity-preserving type toner, from these reports it is found that with science and technology
Development, cosmetics increasingly tend to natural, nutrition, safe and non-stimulating etc..
Currently, inevitably will receive spoke before many white collar, sitting races etc. muchly need to be sitting in computer because of need of work
Shoot evil wounded, these radiation injuries can be further exacerbated by the skin problem of people: dry skin, wrinkle, color spot, pore are coarse etc..
In addition, haze is also increasingly common with the deterioration of environment, these finely ground particle substances in air will lead to skin and aoxidize
Reduction reaction forms free radical, degenerates so as to cause protein function in skin and natural consumes, be easy hematopoiesis flesh
Skin damage, leads to drying, wrinkle, pigment deposition of skin etc..The problems such as dry skin of these aggravations, makes people to moisturizing
The requirement of type toner is higher and higher, in addition to should have better moisturizing moisturizing effect, should also have beautification skin, repair flesh
Skin, anti-ultraviolet radiation, goes the effects of wrinkle at anti-computer low frequency radiation.Therefore, only development function type cosmetics are just able to satisfy the modern times
Demand of the people to cosmetics.
Biological carbohydrate gum -1 is L-fucose, D- galactolipin and the galacturonic acid linear array shape obtained by natural sugar fermentation
At polysaccharide, be primarily present in a variety of brown algas such as bladder-wrack, yellow tang, thallus laminariae, sargassum fusifome, Hai Yun, thickness Ye Xieman algae, kelp
In, containing multiple sulfates, there is polyanionic compound property, be traditionally used for healthy food, pharmaceutical raw material always, have
Anticoagulation, anti-chronic kidney hypofunction, antitumor, antiviral, promotion regeneration, inhibits gastric ulcer, enhancing immunity of organism machine at reducing blood lipid
A variety of physiological activity such as energy.It is a kind of novel moisturizer in cosmetic industry, dispels with good moisture retention and wetability
Wrinkle agent, skin repair agent and skin sense regulator.
Gold medicinal history is of long standing and well established, and Chinese traditional pharmacopeia has different descriptions to the various medicinal functions of gold.Gold
With very strong inoxidizability.The gold foil of ultra tiny molecule is made up of high speed homogenization, it is ultra-fine as activity gold in cosmetics
Particle uses, and the permeability of skin can be improved, adjust the injury that skin soda acid nourishes skin, prevents ultraviolet light, exclude toxin, prevent
Only pigment generates, and long-time service can promote skin metabolism, keeps skin smooth fine and smooth, retains youthful vitality.Meanwhile gold point
Son brings the appearance that unique golden light flashes to product.
Plant amino acid moisturizer is efficient one kind, safety, activity is high, absorbs fast new moisturizer, can be improved rapidly
The moisture holding capacity of skin and hair, activated cell vigor, have the effects that moisturizing, skin softening, it is crease-resistant, brighten, be salubrious, feel is sliding
Refreshing, Cutaneous permeation is quick, additionally has anti-inflammatory and anti-sunlight function.
On these component bases, the collocation of moisturizer used herein also shows unique characteristics, and moisturizing water lock is mutually arranged in pairs or groups, also spy
It is not added to skin conditioning agent, skin brings compact sense after absorbing, abundant moisture and nourishing are brought to skin.These components
Collocation, so that not only replenishing water and preserving moisture effect is good for moisture retention water provided by the present application, skin is compact, has to repair to impaired skin and make
With, also have resistant function to radiation, be extremely applicable to dry skin problem than it is more serious, for a long time be exposed to computer radiation, it is deep by
The modern consumer that atmosphere pollution is stranded uses.
Summary of the invention
To solve the above problems, the purpose of the present invention is to provide a kind of efficient moisture-retention gold moisture retention water of perfect in shape and function,
While efficient moisturizing, also have releive, repair, skin lightening, the U.S. flesh such as compact and anti-inflammatory, anti-radiation effect.
The object of the invention is also to provide a kind of preparation methods of gold moisture retention water.
The present invention provides a kind of gold moisture retention waters, which includes following components in parts by weight:
Preferably, the moisture retention water includes following components in parts by weight:
Further, the thickener includes polyacrylate cross-linked polymer -6, acrylic acid (ester) class/C10-30 alkane
One or both of alcohol acrylate crosspolymers.
Further, the plant amino acid moisturizer includes polyglutamic acid, one in maize gluten amino acids
Kind or two kinds.
Further, the skin conditioning agent includes purslane extract, tulip extract, in glycosphingolipids
It is one or more.
Further, the moisturizer includes hyaluronic acid, 1,3-PD, glycine betaine, trehalose, biological carbohydrate gum-
1, one of -8/5/3 glycerol of PEG/PPG/ polytetramethylene glycol or a variety of.
Further, the chelating agent includes EDETATE SODIUM.
Further, the special additive includes gold foil, the gold content > 99.8% of the gold foil, thickness <
0.1 μm, surface area 80-120cm2；
It is highly preferred that the length and width dimensions of the gold foil are 9.33cm × 9.33cm.
Further, the pH adjusting agent can be any pH adjusting agent commonly used in the art, preferably card wave
Nurse sodium.
Further, the solubilizer can be any solubilizer commonly used in the art, preferably PEG-40 hydrogen
Change castor oil.
Further, the preservative can be any preservative commonly used in the art, preferably methyl hydroxybenzoate,
One of Phenoxyethanol, Chlorphenesin are a variety of.
The present invention also provides a kind of preparation method of gold moisture retention water, which includes the steps that following sequences:
1) ingredient；Prepare each component of the moisture retention water by above-mentioned parts by weight；
2) it prepares；
A. by deionized water, part moisturizer, thickener, natural moisturizing factor is added in pot, with the speed of 30-40 turns/min
Rate stirring, heats up after stirring a period of time；When being warming up to 50 DEG C, start homogeneous, in homogeneous to pot without transparent little particle after, continue
It is warming up to 88-92 DEG C, keeps the temperature 10min at such a temperature；
B. after keeping the temperature, chelating agent and remaining moisturizer is added in pot, starts to cool down；Addition when being cooled to 75-80 DEG C
The methyl hydroxybenzoate dissolved in advance with 1,3- propylene glycol；
When C. continuing to be cooled to 45-50 DEG C, remaining ingredient is sequentially added；
D. after whole components are added, when being cooled to 32 ± 2 DEG C, gone out after product control initial survey is qualified with 100 mesh double-layer filter cloths
Material.
The present invention is to provide a kind of efficient moisture-retention gold moisture retention water of perfect in shape and function, in moisture retention water provided by the invention,
Be added to biological carbohydrate gum -1, be added to plant amino acid moisturizer, be added to natural moisturizing factor, be added to skin conditioning agent,
Be added to the moisturizer of characteristic collocation, be added to gold foil etc., so that moisture retention water provided by the invention is in addition to moisturizing also with more
Kind of effect: releiving, maintenance, anti-inflammatory, skin lightening and careful, radiation protection etc., extremely suitable to be chronically exposed under air-conditioning, environmental pollution
Modern.Compared with prior art, the invention has the following beneficial effects:
1, the replenishing water and preserving moisture effect of gold moisture retention water provided by the invention is strong, and skin sense is sliding；
2, gold moisture retention water provided by the invention has the effect of releiving, and can effectively reduce nitric oxide, inhibits lipoxidase, subtracts
Slow inflammation.
3, gold moisture retention water provided by the invention also has the function of anti-computer low frequency radiation etc., and removing DPPH effect is good, resists
Free radical ability is strong.
4, because being added to gold foil, the importing for being more conducive to moisture retention water absorbs gold moisture retention water provided by the invention, inhales
Skin is compact after receipts.And the addition of goldleaf is so that moisture retention water of the invention has the appearance of unique golden light flashing, it is pleasing,
Splendid usage experience can be brought to consumer.
Specific embodiment
It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not intended to limit the present invention
Range, following component except especially indicate in addition to, calculate in percentage by weight.The surface area of gold foil as described below is
9.33cm × 9.33cm, 1.4g/ piece
Embodiment 1
Gold moisture retention water (does not stick greasy type)
The weight of the moisture retention water each component is shown in Table 1:
Table 1
The gold moisture retention water (not sticking greasy type) the preparation method is as follows:
1, all A2 phase components are mixed and are stirred evenly, material A is obtained；
2,1,3-PD of the methyl hydroxybenzoate in C phase in C phase is dissolved, obtains solution A；
3, the material A for obtaining A phase component, all A1 phase components and step 1 is added in pot, with the speed of 30-40 turns/min
Rate stirring, heats up after stirring 15min；When being warming up to 50 DEG C, start homogeneous, in homogeneous to pot without transparent little particle after, after of continuing rising
Temperature keeps the temperature 10min to 88-92 DEG C at such a temperature, obtains material B；
4, all B phase components are added into the material B that step 3 obtains, start to cool down, when being cooled to 75-80 DEG C, in pot
The solution A that step 2 obtains is added；Continue to cool down, when being cooled to 45-50 DEG C, sequentially adds remaining phase component according to numeric order；
Double with 100 mesh after product control initial survey is qualified when continuing to be cooled to 32 ± 2 DEG C after 5. all components are added in pot
Layer filter cloth discharging.
Embodiment 2
Gold moisture retention water (reinforced)
The weight of the moisture retention water each component is shown in Table 2:
Table 2
The gold moisture retention water (reinforced) the preparation method is as follows:
1, all A2 phase components are mixed and are stirred evenly, material A is obtained；
2,1,3-PD of the methyl hydroxybenzoate in C phase in C phase is dissolved, obtains solution A；
3, the material A for obtaining A phase component, all A1 phase components and step 1 is added in pot, with the speed of 30-40 turns/min
Rate stirring, heats up after stirring 15min；When being warming up to 50 DEG C, start homogeneous, in homogeneous to pot without transparent little particle after, after of continuing rising
Temperature keeps the temperature 10min to 88-92 DEG C at such a temperature, obtains material B；
4, all B phase components are added into the material B that step 3 obtains, start to cool down, when being cooled to 75-80 DEG C, in pot
The solution A that step 2 obtains is added；Continue to cool down, when being cooled to 45-50 DEG C, sequentially adds remaining phase component according to numeric order；
Double with 100 mesh after product control initial survey is qualified when continuing to be cooled to 32 ± 2 DEG C after 5. all components are added in pot
Layer filter cloth discharging.
Comparative example 1
Moisture retention water is free of gold foil, remaining component and parts by weight, the preparation method is the same as that of Example 1.
Comparative example 2
Moisture retention water is free of Sodium Hyaluronate, remaining component and parts by weight, preparation method are the same as implementation without biological carbohydrate gum -1
Example 2.
Comparative example 3
Moisture retention water is free of plant amino acid moisturizer, remaining component and parts by weight, preparation method are the same as embodiment 2.
Comparative example 4
Moisture retention water is free of skin conditioning agent, remaining component and parts by weight, the preparation method is the same as that of Example 1.
Experimental example 1
Moistening effect test
10 ages have participated in clinical trial in 22 to 45 years old women.First surveyed with the test of Japan's skicon skinanalysis apparatus
Water content before examination application.Then, it is attached to respectively with the water-moistened paper of gold moisturizing prepared by embodiment 1-2, comparative example 1-4
Inner forearm different parts 1h tests 1,4, the moisture content of skin after 8h respectively.Each test position is tested 3 times, is averaged
Value, the results are shown in Table 3.
Table 3
Experimental example 2
It releives measure of merit
1, nitric oxide (NO) inhibits test
(1) RAW264.7 cell culture: RAW264.7 cell line is purchased from ATCC cell bank, is incubated at containing 10% tire ox blood
Clearly, in 1% dual anti-RPMI1640 culture solution, 37 DEG C, 5%CO are placed in2In incubator, liquid, passage are periodically changed.
(2) the RAW264.7 cell of logarithmic growth phase, 2 × 105/ hole is inoculated in 24 orifice plates, after cultivating 8-12h, by Raw
The 264.7 moisturizing water process prepared with embodiment 1, comparative example 1, comparative example 4, separately set one group of control for not having to moisturizing water process
Group.The lipopolysaccharides (LPS) for reusing 1 μ g/mL is stimulated, and is stimulated for 24 hours under 37 DEG C of condition of culture；Supernatant is collected, according to total
NO detection kit (being purchased from green skies company, product number S0023) operation, passes through classical Ge Lisishi (Griess) reagent
Detection nitrite the results are shown in Table 4 to determine total NO.
The result shows that the gold moisturizing water energy provided by the present application of appropriate dosage effectively reduces nitric oxide, and effect is excellent
In comparative example.
Table 4
2, lipoxidase (LO) inhibits test
(1) it prepares trishydroxymethylaminomethane (Tris) buffer of 0.1M: trishydroxymethylaminomethane being taken (to be purchased from
Sigma company) 12.11g, add water 800mL, stirring and dissolving, and be diluted to 1000mL, with 6mol/L hydrochloric acid solution adjust pH value to
8.0；
(2) it prepares lipoxidase solution: taking the lipoxidase (purchased from Sigma company) of 60 μ L, it is prepared with step (1)
Buffer is diluted to 10mL；
(3) mixed solution of moisture retention water and lipoxidase is prepared: by volume ratio shown in table 5 respectively by embodiment 2, comparative example
2, the moisture retention water that comparative example 3 provides is added in the lipoxidase solution (taking 100 μ L) that step (2) obtains, and sets blank control
Group reacts 5min at 25 DEG C；
(4) it prepares Linoleic Acid solution: weighing linoleic acid (purchased from Sigma company) 25.0mg, set in 10ml measuring bottle, add
Tween-2025 μ L, adds water 6ml, shakes up, and adds 200 μ L of 1mol/LNaOH solution to make to dissolve, is diluted with water to scale, shakes up, i.e.,
?；
(5) moisture retention water and lipoxidase that step (3) obtain is added in the Linoleic Acid solution for taking 10 μ L steps (4) to prepare respectively
Mixed solution in, and with step (1) prepare Tris buffer total volume is mended to 150 μ L；Then ELISA reader is used
Test each group Lipoxygenase activity.
According to formula: lipoxygenase inhibitory activity %=[(survey by the Lipoxygenase activity that blank control group measures-experimental group
Lipoxygenase activity) Lipoxygenase activity that measures of/blank control group] * 100；
Calculate lipoxygenase inhibitory activity.It the results are shown in Table 5, as can be seen from the results, gold moisture retention water provided by the present application can have
Effect inhibits Lipoxygenase activity, and significant effect is better than comparative example.
Table 5
Experimental example 3
1,1- diphenyl -2- trinitrophenyl-hydrazine (DPPH) radicals scavenging test
(1) prepare DPPH solution: DPPH is purchased from Shanghai Ru Ji biotechnology Development Co., Ltd, accurately weighs 40mg
DPPH, dehydrated alcohol are settled to 250mL, shake up concentration be 4 × 10-4The DPPH solution of mol/L refrigerates spare.
(2) 1/ embodiment of DPPH solution and 4mL embodiment of 4mL step (1) preparation is sequentially added in 10mL colorimetric cylinder
The moisture retention water that 2/ comparative example, 1/ comparative example, 2/ comparative example, 3/ comparative example 4 is prepared adds dehydrated alcohol to scale, mixes vertical
Light absorption value (A) is surveyed at 517nm wavelength with 1cm cuvette, light absorption value is denoted as Ai, then surveys after 30min is kept in dark place in greenhouse
Light absorption value is denoted as Aj, and check experiment is only plus the ethanol solution of DPPH, light absorption value are denoted as Ac.Same measurement is repeated 3 times, and is taken
Average value.
Free radical scavenging activity (K): K (%)=[1- (Ai-Aj)/Ac] * 100% is calculated as follows；It the results are shown in Table 6.By table 6
As a result it is found that gold moisture retention water provided by the present application can effectively remove DPPH, significant effect is better than comparative example.
Table 6
| Group | DPPH clearance rate (K) |
| Embodiment 1 | 96.55 |
| Embodiment 2 | 98.73 |
| Comparative example 1 | 79.82 |
| Comparative example 2 | 80.13 |
| Comparative example 3 | 81.25 |
| Comparative example 4 | 80.61 |
Claims (1)
1. a kind of gold moisture retention water, the moisture retention water contain following components in parts by weight:
81.52 parts of water,
- 6 0.30 parts of polyacrylate cross-linked polymer,
0.08 part of carbomer sodium,
1.4 parts of gold foil,
0.12 part of polyglutamic acid,
0.005 part of Sodium Hyaluronate,
3.00 parts of 1,3-PD,
0.01 part of EDETATE SODIUM,
5.00 parts of glycine betaine,
2.00 parts of maize gluten amino acids,
- 1 2.00 part of biological carbohydrate gum,
1.00 parts of 1,3-PD,
0.12 part of methyl hydroxybenzoate,
0.08 part of Cremophor RH40,
0.005 part of essence,
1.00 parts of -8/5/3 glycerol of PEG/PPG/ polytetramethylene glycol,
0.50 part of purslane extract,
1.00 parts of glycosphingolipids,
0.27 part of Phenoxyethanol,
0.09 part of Chlorphenesin,
0.50 part of Flos Tulipae Gesnerianae extract.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711252586.0A CN107737058B (en) | 2017-12-01 | 2017-12-01 | - 1 gold moisture retention water of a kind of biological carbohydrate gum and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711252586.0A CN107737058B (en) | 2017-12-01 | 2017-12-01 | - 1 gold moisture retention water of a kind of biological carbohydrate gum and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN107737058A CN107737058A (en) | 2018-02-27 |
| CN107737058B true CN107737058B (en) | 2019-03-22 |
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| CN109106634A (en) * | 2018-08-01 | 2019-01-01 | 广州皓雨投资有限公司 | A kind of composition containing goldleaf and red ginseng extract, sleep mask and preparation method thereof |
| CN109481390A (en) * | 2018-12-03 | 2019-03-19 | 广州市皓雨化妆品有限公司 | It is a kind of with moisturizing, whitening, the composition of Antiageing effect and its application |
| CN110522656A (en) * | 2019-09-16 | 2019-12-03 | 中山市美源化妆品有限公司 | Adornment foremilk |
| CN110652470A (en) * | 2019-10-17 | 2020-01-07 | 广州市千邦化妆品有限公司 | Moisturizing repair water and preparation method thereof |
| CN113750029A (en) * | 2020-06-07 | 2021-12-07 | 美歆然化妆品(上海)有限公司 | Soothing and repairing essence and preparation method thereof |
| CN113143837A (en) * | 2021-02-07 | 2021-07-23 | 深圳市琉璃光生物科技有限公司 | Anti-aging skin-tendering composition and preparation method thereof |
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| CN101711733A (en) * | 2009-11-30 | 2010-05-26 | 常帅 | Nano gold essential oil liquid |
| CN104814896B (en) * | 2015-05-08 | 2018-03-23 | 广州依侬化妆品有限公司 | A kind of skin care item |
| CN106109296B (en) * | 2016-06-30 | 2018-02-09 | 彭燕辉 | A kind of moisturizing essence lotion and preparation method thereof |
| CN106667838B (en) * | 2016-12-30 | 2020-01-10 | 广东巧巧生物科技有限公司 | Preparation method of flower toning lotion capable of keeping color, fresh and shape for a long time |
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Address after: 516000 Peng's Workshop of Yingguang Village Industrial Park, Lilin Town, Zhongkai High-tech Zone, Huizhou City, Guangdong Province Patentee after: Luxinyan (Guangdong) Biotechnology Co.,Ltd. Address before: 516000 Peng's Workshop of Yingguang Village Industrial Park, Lilin Town, Zhongkai High-tech Zone, Huizhou City, Guangdong Province Patentee before: LUXINYAN (HUIZHOU) BIOLOGICAL TECHNOLOGY Co.,Ltd. |
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Effective date of registration: 20221208 Address after: 516006 YingGuang Village Industrial Park, Lilin Town, Zhongkai high tech Zone, Huizhou City, Guangdong Province Patentee after: Peng Shi (Huizhou) Industrial Development Co.,Ltd. Address before: 516000 Peng's Workshop of Yingguang Village Industrial Park, Lilin Town, Zhongkai High-tech Zone, Huizhou City, Guangdong Province Patentee before: Luxinyan (Guangdong) Biotechnology Co.,Ltd. |