CN107802540A - A kind of anti-apolexis composition and its application - Google Patents
A kind of anti-apolexis composition and its application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses a kind of anti-apolexis composition, and comprising polypeptide moiety and anti-aging plant extracts, the anti-aging plant extracts is at least one of alfalfa root nodule extract, stalwart mugwort extract, Rhizoma Polygonati extract, chervil extract.Composition of the present invention includes polypeptide moiety and anti-aging plant extracts simultaneously, and the two can play synergistic function, reach preferable senile-resistant efficacy.Meanwhile the application the invention also discloses the anti-apolexis composition in cosmetics.
Description
Technical field
The present invention relates to a kind of composition, especially a kind of anti-apolexis composition and its application, belong to cosmetic field.
Background technology
The free radical theory of aging thinks that the degeneration change in aging course is due to be produced in cell normal metabolic processes
Caused by the illeffects of raw free radical.The aging course of organism is the constantly caused free radical product of histocyte of body
Tired result, free radical can cause DNA damage, and so as to cause to be mutated, induced tumor is formed.Free radical is the centre of eubolism
Product, its respond is very strong, can aoxidize many kinds of substance in cell, infringement biomembrane, caused by excessive free radicals
Oxidative stress is the major reason for causing aging.Skin senescence as a result, skin is easier to drying；Skin elasticity is deteriorated, skin
It is thinning, there is wrinkle；Sebaceous gland activity lowers, and secretion is reduced；Grow pigmented spots；Restored after skin damage it is slack-off, and relatively hold
It is blue or green that the stasis of blood easily occurs.
Free radical, " free radical " is chemically also referred to as, is the atomic group containing a unpaired electron.Because atom is formed
During molecule, electronics must occur in pairs in chemical bond, therefore free radical just captures an electronics of other materials everywhere, makes oneself
Form stable material.In chemistry, this phenomenon referred to as " aoxidizes ".What our biosystems mainly ran into is oxygen radical,
Such as ultra-oxygen anion free radical, hydroxy radical, fat oxygen radical, nitrogen dioxide and nitric oxide free radical, plus peroxidating
Hydrogen, singlet oxygen and ozone, are generally called active oxygen, and active oxygen radical accounts for more than the 95% of interior free yl.Activity in vivo oxygen is certainly
There is certain function by base, such as immune and signal transduction process.But excessive active oxygen radical just has destruction, leads
The damage of human normal cell and tissue is caused, so as to cause a variety of diseases.In addition, the solar irradiation, air in external environment are dirty
Dye, smoking, agricultural chemicals etc. can all make human body produce more active oxygen radicals, make nucleic acid mutation, this is mankind aging and illness
Root.
The content of the invention
Based on this, it is an object of the invention to provide a kind of anti-apolexis composition regarding to the issue above.
To achieve the above object, the technical solution used in the present invention is：A kind of anti-apolexis composition, includes polypeptide moiety
With anti-aging plant extracts, the anti-aging plant extracts is alfalfa root nodule extract, stalwart mugwort extract, sealwort carry
Take at least one of thing, chervil extract.
Composition of the present invention includes polypeptide moiety and anti-aging plant extracts simultaneously, and the two can play collaboration and increase
Effect acts on, and reaches preferable senile-resistant efficacy.
Preferably, the parts by weight of the polypeptide moiety are 1.8~17 parts, and the parts by weight of the anti-aging plant extracts are
4~40 parts.
By a large amount of creative exploration discoveries, the polypeptide moiety of above-mentioned parts by weight and anti-aging plant carry present inventor
Thing is taken, can further play synergistic function, reaches more preferable senile-resistant efficacy.
Preferably, the polypeptide moiety is myristoyl pentapeptide -4, pentapeptide -1, the cetyl of acetyl group dipeptides -1, dipeptides two
At least one of aminobutyryl benzyl amide diacetin.
It is highly preferred that the peptide composition is myristoyl pentapeptide -4, pentapeptide -1, the cetyl of acetyl group dipeptides -1, two
The mixture of peptide diaminobutyryl benzyl amide diacetin.
Myristoyl pentapeptide -4：With prominent anti-aging, repair impaired skin, stimulation collagen synthetic effect；
Pentapeptide -1：It amino acid small molecule, can directly be absorbed by cell, skin collagen hyperplasia can be promoted；
The cetyl of acetyl group dipeptides -1：Contraction of muscle can be avoided, the generation of dynamic line is reduced, smoothes away wrinkles, effectively again
Tissue collagen elasticity, strengthens the activity of elastin, loosens face's lines, and wrinkle smooths improvement relaxation；
Dipeptides diaminobutyryl benzyl amide diacetin：It is a kind of synthesis victory peptide for simulating calmette's serum, second can be prevented
The nerve conduction of phatidylcholine, reach the effect to relax one's muscles, so as to improve dynamic wrinkle；
Above-mentioned four kinds of composition collective effects, can further play synergistic function, reach more preferable anti-aging effects.
It is highly preferred that the myristoyl pentapeptide -4, pentapeptide -1, the cetyl of acetyl group dipeptides -1, dipeptides diaminobutyryl benzyl
The weight ratio of base acid amides diacetin is：Myristoyl pentapeptide -4：Pentapeptide -1：The cetyl of acetyl group dipeptides -1：Dipeptides diaminourea fourth
Acyl benzyl amide diacetin=(0.5-5)：(0.5-5)：(0.5-5)：(0.3-2).
Above-mentioned weight than four kinds of compositions, can further play synergistic function, reach more preferable senile-resistant efficacy.
Preferably, the anti-aging plant extracts is alfalfa root nodule extract, stalwart mugwort extract, sealwort extraction
The mixture of thing, chervil extract.
Alfalfa (MEDICAGO SATIVA) root nodule extract, the generation to collagen have facilitation, have crease-resistant
Effect；There is water imbibition simultaneously, the effect for having moisturizing.
Stalwart wormwood artemisia (ARTEMISIA PRINCEPS) leaf extract, Stratum Corneum cell have proliferation function, it is thin can to strengthen skin
Born of the same parents' metabolism, there is skin-active and Antiageing effect；It can be used as antioxidant, skin-whitening agents and antiinflammatory simultaneously.
Sealwort (POLYGONATUM SIBIRICUM) extract, there is fine facilitation to collagen propagation, therefore can
Strengthen the metabolism of dermal layer of the skin, furthermore with inoxidizability, can be used in skin-active anti-wrinkle cosmetic.
Chervil (SCABIOSA ARVENSIS) extract, can effectively scavenging hydroxyl, superoxide radical, there is antioxygen
The effect of change.
Above-mentioned Four Plants extract, can play synergistic function, reach preferable senile-resistant efficacy.
It is highly preferred that the alfalfa root nodule extract, stalwart mugwort extract, Rhizoma Polygonati extract, the weight of chervil extract
Measuring ratio is：Alfalfa root nodule extract：Stalwart mugwort extract：Rhizoma Polygonati extract：Chervil extract=(1-10)：(1-10)：
(1-10)：(1-10).
Above-mentioned weight than four kinds of compositions, can further play synergistic function, reach more preferable senile-resistant efficacy.
It is highly preferred that the alfalfa root nodule extract, stalwart mugwort extract, Rhizoma Polygonati extract, the weight of chervil extract
Measuring ratio is：Alfalfa root nodule extract：Stalwart mugwort extract：Rhizoma Polygonati extract：Chervil extract=(2-3)：(3-5)：(3-
5)：(4-6).
Meanwhile present invention also offers a kind of cosmetics for including above-mentioned composition, the cosmetics have preferably anti-
Aging effect.
Preferably, weight/mass percentage composition of the anti-apolexis composition in the cosmetics is 0.5-10%.
Preferably, described cosmetics, also comprising cosmetics exterior-applied formulation matrix.
Relative to prior art, beneficial effects of the present invention are：
Composition of the present invention includes polypeptide moiety and anti-aging plant extracts simultaneously, and the two can play collaboration and increase
Effect acts on, and reaches preferable senile-resistant efficacy.Meanwhile the polypeptide moiety is again comprising myristoyl pentapeptide -4, pentapeptide -1, acetyl
The cetyl of base dipeptides -1, dipeptides diaminobutyryl benzyl amide diacetin, the plant extracts carry comprising alfalfa root nodule
Thing, stalwart mugwort extract, Rhizoma Polygonati extract, chervil extract are taken, these compositions can further play synergistic function, reach
To more surprising anti-aging effects.
Embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
It should be noted that the unspecified technological parameter of the present invention, raw material etc. are according to this area routine techniques hand
Duan Jinhang.
Embodiment 1
A kind of embodiment of anti-apolexis composition of the present invention, anti-apolexis composition described in the present embodiment include following heavy
Measure the composition of part：
Polypeptide moiety (- 4 0.5 parts of myristoyl pentapeptide, 0.5 part of pentapeptide -1,0.5 part of -1 cetyl of acetyl group dipeptides, dipeptides
0.3 part of diaminobutyryl benzyl amide diacetin) 1.8 parts, anti-aging plant extracts (1 part of alfalfa root nodule extract, chief
1 part of mugwort extract, 1 part of Rhizoma Polygonati extract, 1 part of chervil extract) 4 parts.
A kind of cosmetics for including above-mentioned composition, weight/mass percentage composition of the above-mentioned composition in the cosmetics are
0.5%, also comprising cosmetics exterior-applied formulation matrix, described cosmetics exterior-applied formulation matrix those skilled in the art can be according to reality
Border needs to carry out conventional selection, and the cosmetics can conventionally prepare gained.
Embodiment 2
A kind of embodiment of anti-apolexis composition of the present invention, anti-apolexis composition described in the present embodiment include following heavy
Measure the composition of part：
Polypeptide moiety (- 45 parts of myristoyl pentapeptide, 5 parts of pentapeptide -1,5 parts of -1 cetyl of acetyl group dipeptides, dipeptides diaminourea
2 parts of butyryl benzyl amide diacetin) 17 parts, anti-aging plant extracts (10 parts of alfalfa root nodule extract, the extraction of stalwart mugwort
10 parts of thing, 10 parts of Rhizoma Polygonati extract, 10 parts of chervil extract) 40 parts.
A kind of cosmetics for including above-mentioned composition, weight/mass percentage composition of the above-mentioned composition in the cosmetics are
2%, also comprising cosmetics exterior-applied formulation matrix, described cosmetics exterior-applied formulation matrix those skilled in the art can be according to reality
Need to carry out conventional selection, the cosmetics can conventionally prepare gained.
Embodiment 3
A kind of embodiment of anti-apolexis composition of the present invention, anti-apolexis composition described in the present embodiment include following heavy
Measure the composition of part：
Polypeptide moiety (- 4 2.5 parts of myristoyl pentapeptide, 3 parts of pentapeptide -1,4 parts of -1 cetyl of acetyl group dipeptides, dipeptides diamino
1 part of base butyryl benzyl amide diacetin) 10.5 parts, anti-aging plant extracts (5 parts of alfalfa root nodule extract, stalwart mugwort
4 parts of extract, 6 parts of Rhizoma Polygonati extract, 7 parts of chervil extract) 22 parts.
A kind of cosmetics for including above-mentioned composition, weight/mass percentage composition of the above-mentioned composition in the cosmetics are
4%, also comprising cosmetics exterior-applied formulation matrix, described cosmetics exterior-applied formulation matrix those skilled in the art can be according to reality
Need to carry out conventional selection, the cosmetics can conventionally prepare gained.
Embodiment 4
A kind of embodiment of anti-apolexis composition of the present invention, anti-apolexis composition described in the present embodiment include following heavy
Measure the composition of part：
Polypeptide moiety (- 44 parts of myristoyl pentapeptide, 3 parts of pentapeptide -1,2 parts of -1 cetyl of acetyl group dipeptides, dipeptides diaminourea
1 part of butyryl benzyl amide diacetin) 10 parts, anti-aging plant extracts (2 parts of alfalfa root nodule extract, the extraction of stalwart mugwort
4 parts of thing, 6 parts of Rhizoma Polygonati extract, 8 parts of chervil extract) 20 parts.
A kind of cosmetics for including above-mentioned composition, weight/mass percentage composition of the above-mentioned composition in the cosmetics are
6%, also comprising cosmetics exterior-applied formulation matrix, described cosmetics exterior-applied formulation matrix those skilled in the art can be according to reality
Need to carry out conventional selection, the cosmetics can conventionally prepare gained.
Embodiment 5
A kind of embodiment of anti-apolexis composition of the present invention, anti-apolexis composition described in the present embodiment include following heavy
Measure the composition of part：
Polypeptide moiety (myristoyl pentapeptide -4, pentapeptide -1, the cetyl of acetyl group dipeptides -1, dipeptides diaminobutyryl benzyl acyl
The weight ratio of amine diacetin is 0.5:1:5:2) 8 parts, (alfalfa root nodule extract, stalwart mugwort carry anti-aging plant extracts
It is 2 to take thing, Rhizoma Polygonati extract, the weight ratio of chervil extract:3:3:4) 30 parts.
A kind of cosmetics for including above-mentioned composition, weight/mass percentage composition of the above-mentioned composition in the cosmetics are
8%, also comprising cosmetics exterior-applied formulation matrix, described cosmetics exterior-applied formulation matrix those skilled in the art can be according to reality
Need to carry out conventional selection, the cosmetics can conventionally prepare gained.
Embodiment 6
A kind of embodiment of anti-apolexis composition of the present invention, anti-apolexis composition described in the present embodiment include following heavy
Measure the composition of part：
Polypeptide moiety (myristoyl pentapeptide -4, pentapeptide -1, the cetyl of acetyl group dipeptides -1, dipeptides diaminobutyryl benzyl acyl
The weight ratio of amine diacetin is 5:1:3:0.3) 17 parts, (alfalfa root nodule extract, stalwart mugwort carry anti-aging plant extracts
It is 3 to take thing, Rhizoma Polygonati extract, the weight ratio of chervil extract:5:5:6) 4 parts.
A kind of cosmetics for including above-mentioned composition, weight/mass percentage composition of the above-mentioned composition in the cosmetics are
10%, also comprising cosmetics exterior-applied formulation matrix, described cosmetics exterior-applied formulation matrix those skilled in the art can be according to reality
Border needs to carry out conventional selection, and the cosmetics can conventionally prepare gained.
Embodiment 7
A kind of embodiment of anti-apolexis composition of the present invention, anti-apolexis composition described in the present embodiment include following heavy
Measure the composition of part：
Polypeptide moiety (myristoyl pentapeptide -4, pentapeptide -1, the cetyl of acetyl group dipeptides -1, dipeptides diaminobutyryl benzyl acyl
The weight ratio of amine diacetin is 1:1:5:1) 1.8 parts, (alfalfa root nodule extract, stalwart mugwort carry anti-aging plant extracts
It is 2.5 to take thing, Rhizoma Polygonati extract, the weight ratio of chervil extract:4:4:5) 40 parts.
A kind of cosmetics for including above-mentioned composition, weight/mass percentage composition of the above-mentioned composition in the cosmetics are
4%, also comprising cosmetics exterior-applied formulation matrix, described cosmetics exterior-applied formulation matrix those skilled in the art can be according to reality
Need to carry out conventional selection, the cosmetics can conventionally prepare gained.
Embodiment 8
Scavenging action to hydroxyl free radical is tested
Control group 1~3 is set, and in control group 1 in addition to polypeptide moiety is not contained, other are in the same manner as in Example 3, control
Except anti-aging plant extract beyond the region of objective existence is not contained in group 2, other are in the same manner as in Example 3, and the present invention is not both contained in control group 3
Polypeptide moiety, do not contain the anti-aging plant extracts in the present invention yet, other exterior-applied formulation matrix and embodiment 3 in phase
Together.
Reagent：The ethanol solution of 1.865mmol/L Phens, the 0.2M phosphate buffers of pH 7.4,
The H of 1.865mmol/L FeSO47H2O solution, 0.03% (v/v)2O2, distilled water, 0.8mg/ml prepare liquids.
Method：The ethanol solution that 1.0mL concentration is 1.865mmol/L Phens is taken in test tube with ground stopper, respectively
Phosphate buffer 2mL and the 1mL prepare liquids of pH 7.4 that concentration is 0.2mol/L are added, 1.0mL concentration is added after fully mixing
For 1.865mmol/L FeSO4·7H2O solution, 1.0mL 0.03% (v/v) H is added after mixing again2O2, in 37 DEG C of perseverances
Tepidarium, after 60min, the absorbance for measuring each group mixed solution respectively under 536nm obtains As, is made with distilled water instead of sample
Absorbance is surveyed for blank group and obtains Ab, and H is substituted with distilled water2O2As damage group, its absorbance An, the hydroxyl of antioxidant are surveyed
Free radical scavenging activity calculates as follows：Scavenging action to hydroxyl free radical (%)=[(As-An)/(Ab-An)] × 100, takes three times
The average value of measurement, testing result are as shown in table 1.
DPPH free radical scavenging activities are tested
Reagent：0.0178mmol/L DPPH- absolute methanol solutions, absolute ethyl alcohol, 0.8mg/ml prepare liquids.
Method：The DPPH- absolute methanol solutions that concentration is 3mL 0.0178mmol/L are taken to add 3mL in cuvette
Prepare liquid, mixing and light absorption value is surveyed at 517nm wavelength immediately survey, light absorption value is designated as Ai, then after 30min is kept in dark place at 37 DEG C
Light absorption value is surveyed, is designated as Aj, only to add DPPH- absolute methanol solutions, its light absorption value is designated as Ac for blank control.DPPH is calculated as follows
Free radical scavenging activity：DPPH free radical scavenging activities (%)=[1- (Ai-Aj)/Ac] × 100%, take the average value measured three times,
Testing result is as shown in table 1.
The free radical scavenging activity of table 1 is tested
As it can be seen from table 1 compared with comparative example 3 (not containing plant extracts and polypeptide moiety of the present invention), it is real
Example 1~7 (containing plant extracts and polypeptide moiety), comparative example 1 (comprising only plant extracts), comparative example 2 is applied (to comprise only more
Peptide components) free radical scavenging activity is apparently higher than comparative example 3, hence it is evident that there are more preferable anti-aging effects, this explanation present invention makes up
Plant extracts and polypeptide moiety are respectively provided with the performance of excellent removing free radical in product.Meanwhile with comparative example 1 and comparative example 2
Compare, embodiment 1-7 adds the skin care item of plant extracts and polypeptide moiety simultaneously, and its free radical scavenging activity is higher than comparative example 1
Both remove free radical rate sum with comparative example 2, this explanation plant extracts and polypeptide moiety, both Synergistics, have more
Good senile-resistant efficacy.
Embodiment 9
(1) skin roughness is tested：
Test pre-treatment：Test population is that average age is 35-45 year and has lossless the wounded of wrinkle, skin health 40,
4 groups are randomly divided into, every group 10, prepares gained cosmetics using composition in embodiment 1~7 respectively.Subject applies in face
Test specimen is smeared, daily morning and evening spread product is twice.During experiment, subject can not smear any other cosmetic in Test sites
Product.Subject is tested after continuous use test specimen 0 week, 1 week, 2 weeks, 3 weeks, 4 weeks.
Skin roughness is tested：Using wrinkle of skin tester VISIOMETER SV600 test respectively the 0th week, 1 week, 2
Week, 3 weeks, the skin condition of 4 weeks, test position is cheekbone portion.Test parameter is that skin roughness R1 (is dermatoglyph from top to most
The difference of low ebb) ,-the 0 week R1 value of R1 average change values=4th week R1 values, the R1 average rates of change=R1 average change values/0th
All R1 values.Mean roughness R3 (being the arithmetic mean of instantaneous value of the different partitioning portion of continuous 5 length identicals), R2 mean changes
It is worth-the 0 week R3 value of=the 4 week R3 value, the R3 average rates of change=R3 average change values/0th week R3 values.R1 and R3 numerical value is got over
Greatly, wrinkle is more serious, and specific R1, R3 test result is respectively as shown in table 2, table 3：
Table 2 uses the change of skin roughness R1 after cosmetics prepared by composition in embodiment 1~7
| Group | Average change value (mm) | The average rate of change (%) |
| Embodiment 1 | -0.73 | -39.74 |
| Embodiment 2 | -0.78 | -41.56 |
| Embodiment 3 | -0.80 | -43.92 |
| Embodiment 4 | -0.84 | -46.00 |
| Embodiment 5 | -0.87 | -47.89 |
| Embodiment 6 | -0.91 | -48.24 |
| Embodiment 7 | -0.99 | -48.97 |
Table 3 uses the change of skin mean roughness R3 after cosmetics prepared by composition in embodiment 1~7
It can be drawn by the experimental result of table 2, can significantly be dropped using cosmetics prepared by composition in embodiment 1~7
Difference of the low dermatoglyph from top to lowest trough, that is, the roughness of skin is significantly reduced, after the product four weeks, skin
Roughness can reduce by more than 39.74%.
It can be drawn by the experimental result of table 3, after cosmetics four weeks prepared by composition in embodiment 1~7, skin
Mean roughness can reduce by more than 40.97%.It can be drawn by the result of table 2 and table 3, can be with using the cosmetics of the present invention
Effectively reduce wrinkle.
(2) skin elasticity is tested：
Test pre-treatment：Test population is that average age is 35-45 year and has lossless the wounded of wrinkle, skin health 40,
4 groups are randomly divided into, every group 10, prepares gained cosmetics using composition in embodiment 1~7 respectively.Subject applies in face
Test specimen is smeared, daily morning and evening spread product is twice.During experiment, subject can not smear any other cosmetic in Test sites
Product.Subject is tested after continuous use test specimen 0 week, 1 week, 2 weeks, 3 weeks, 4 weeks.
Skin elasticity is tested：Using skin elasticity instrument Cutometer MPA580 test respectively the 0th week, 1 week, 2 weeks, 3 weeks,
The skin condition of 4 weeks, test position are cheekbone portion, and probe is averaged in same tested region duplicate measurements 3 times during measurement.Survey
Examination parameter is R2 (the ratio between the springback capacity Ua of skin and maximum tension amount Uf when having a negative pressure during no negative pressure), and R2 is closer to 1, skin
Elastic better ,-the 0 week R2 value of R2 average change values=4th week R2 values, the R2 average rates of change=R2 average change values/0th
All R2 values.The test result of specific skin elasticity is as shown in table 4：
Table 4 prepares the change of skin elasticity R2 after gained cosmetics using composition in embodiment 1~7
Preparing gained cosmetics using composition in embodiment 1~7 it can be seen from the data of table 4 can effectively improve
The elasticity of skin, illustrate that the product of the present invention can effective anti-aging.
Embodiment 10
Experiment is divided into control group and experimental group, and control group is only to include cosmetics exterior-applied formulation matrix, totally 21 groups of experimental group,
Wherein experimental group 1~7 is respectively comprising cosmetics, the cosmetics of experimental group 8~21 prepared by the composition in embodiment 1~7
In contained component except myristoyl pentapeptide -4, pentapeptide -1, the cetyl of acetyl group dipeptides -1, dipeptides diaminobutyryl benzyl amide
The content of four kinds of compositions of diacetin is different outer, and other compositions are same as Example 3, and (four kinds of compositions are in the cosmetics
Total content is identical, and simply weight is than different), myristoyl pentapeptide-4, pentapeptide-1, acetyl group dipeptides in specific experiment group 8~21-
The weight ratio of 1 cetyl, dipeptides diaminobutyryl benzyl amide four kinds of compositions of diacetin, as shown in table 5：
Myristoyl pentapeptide -4, pentapeptide -1, the cetyl of acetyl group dipeptides -1, dipeptides in the cosmetics of 5 experimental group of table 8~21
The weight ratio of four kinds of compositions of diaminobutyryl benzyl amide diacetin
In control group and experimental group, every group randomly selects 10 have the lossless the wounded of wrinkle, skin health 35~45 years old
Women uses the cosmetics for only including cosmetics exterior-applied formulation matrix, experimental group 1 as subjects, the subjects of control group
~7 subjects use the cosmetics for including 1~7 composition of embodiment, the subjects point of experimental group 8~21 respectively
The cosmetics not being prepared using experimental group 8~21, tested using application method same as Example 9 and skin roughness
Method test uses front and rear skin mean roughness situation of change, as a result as shown in table 6.
The skin mean roughness R3 of table 6 change
As seen from Table 6, compared with the cosmetics of control group, the cosmetics of experimental group 1~21 are all with preferably anti-ageing
Old effect.And contain myristoyl pentapeptide -4, pentapeptide -1, the cetyl of acetyl group dipeptides -1, two in the cosmetics of experimental group 1~7
Peptide diaminobutyryl benzyl amide four kinds of compositions of diacetin, effect are best.Pork and beans is comprised only in the cosmetics of experimental group 8~21
In cool acyl pentapeptide -4, pentapeptide -1, the cetyl of acetyl group dipeptides -1, dipeptides diaminobutyryl benzyl amide four kinds of compositions of diacetin
One kind, two or three, anti-ageing effect is slightly weak, illustrate the present invention cosmetics in, myristoyl pentapeptide -4, pentapeptide -1, second
Four kinds of cetyl of acyl group dipeptides -1, dipeptides diaminobutyryl benzyl amide diacetin compositions, which have, mutually promotes, mutually cooperates with
Effect, significant anti-aging effects can be played.
Embodiment 11
Experiment is divided into control group and experimental group, and control group is only to include cosmetics exterior-applied formulation matrix, totally 21 groups of experimental group,
Wherein experimental group 1~7 is respectively cosmetics prepared by the composition in embodiment 1~7, institute in the cosmetics of experimental group 8~21
The component contained is except alfalfa root nodule extract, stalwart mugwort extract, Rhizoma Polygonati extract, the content of four kinds of compositions of chervil extract
Different outer, other compositions are same as Example 3, and (total content of four kinds of compositions in the cosmetics is identical, simply weight ratio
It is different), alfalfa root nodule extract, stalwart mugwort extract, Rhizoma Polygonati extract, chervil extract four in specific control group 1~14
The weight of kind composition is than as shown in table 7：
Alfalfa root nodule extract, stalwart mugwort extract, Rhizoma Polygonati extract, chervil in the cosmetics of 7 experimental group of table 8~21
The weight ratio of four kinds of compositions of extract
| Group | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 |
| Alfalfa root nodule extract | 5 | 0 | 0 | 0 | 5 | 5 | 5 | 0 | 0 | 0 | 5 | 5 | 0 | 5 |
| Stalwart mugwort extract | 0 | 4 | 0 | 0 | 4 | 0 | 0 | 4 | 4 | 0 | 4 | 4 | 4 | 0 |
| Rhizoma Polygonati extract | 0 | 0 | 6 | 0 | 0 | 6 | 0 | 6 | 0 | 6 | 6 | 0 | 6 | 6 |
| Chervil extract | 0 | 0 | 0 | 7 | 0 | 0 | 7 | 0 | 7 | 7 | 0 | 7 | 7 | 7 |
In control group and experimental group, every group randomly selects 10 have the lossless the wounded of wrinkle, skin health 35~45 years old
Women is real respectively using the cosmetics for only including cosmetics exterior-applied formulation matrix as subjects, the subjects of control group
Test the cosmetics that the subjects of group 1~7 include the composition using embodiment 1~7 respectively, the experiment of experimental group 8~21
The cosmetics that object is prepared using experimental group 8~21 respectively, using application method and pachylosis same as Example 9
Spend method of testing test and use front and rear skin mean roughness situation of change, as a result as shown in table 8.
The skin mean roughness R3 of table 8 change
As seen from Table 8, compared with the cosmetics of control group, the cosmetics of experimental group 1~21 are all with preferably anti-ageing
Old effect.Contain alfalfa root nodule extract, stalwart mugwort extract, Rhizoma Polygonati extract, chervil in the cosmetics of experimental group 1~7
Four kinds of compositions of extract, there are good anti-aging effects.The extraction of alfalfa root nodule is comprised only in the cosmetics of experimental group 8~21
Thing, stalwart mugwort extract, Rhizoma Polygonati extract, one kind in four kinds of compositions of chervil extract, two or three, anti-aging effects
It is slightly weak, in the cosmetics for illustrating the present invention, alfalfa root nodule extract, stalwart mugwort extract, Rhizoma Polygonati extract, chervil extraction
Four kinds of compositions of thing have the function that to mutually promote, mutually cooperateed with, and can play significant anti-aging effects.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than the present invention is protected
The limitation of scope is protected, although being explained in detail with reference to preferred embodiment to the present invention, one of ordinary skill in the art should
Understand, technical scheme can be modified or equivalent substitution, without departing from the essence of technical solution of the present invention
And scope.
Claims (10)
1. a kind of anti-apolexis composition, it is characterised in that comprising polypeptide moiety and anti-aging plant extracts, the anti-aging is planted
Thing extract is at least one of alfalfa root nodule extract, stalwart mugwort extract, Rhizoma Polygonati extract, chervil extract.
2. anti-apolexis composition as claimed in claim 1, it is characterised in that the parts by weight of the polypeptide moiety are 1.8~17
Part, the parts by weight of the anti-aging plant extracts are 4~40 parts.
3. anti-apolexis composition as claimed in claim 1 or 2, it is characterised in that the polypeptide moiety be myristoyl pentapeptide-
4th, at least one of pentapeptide -1, the cetyl of acetyl group dipeptides -1, dipeptides diaminobutyryl benzyl amide diacetin.
4. anti-apolexis composition as claimed in claim 3, it is characterised in that the polypeptide moiety be myristoyl pentapeptide -4,
Pentapeptide -1, the cetyl of acetyl group dipeptides -1, the mixture of dipeptides diaminobutyryl benzyl amide diacetin.
5. anti-apolexis composition as claimed in claim 4, it is characterised in that the myristoyl pentapeptide -4, pentapeptide -1, acetyl group
The cetyl of dipeptides -1, the weight ratio of dipeptides diaminobutyryl benzyl amide diacetin are：Myristoyl pentapeptide -4：Pentapeptide -1：Second
The cetyl of acyl group dipeptides -1：Dipeptides diaminobutyryl benzyl amide diacetin=(0.5-5)：(0.5-5)：(0.5-5)：
(0.3-2)。
6. anti-apolexis composition as claimed in claim 3, it is characterised in that the anti-aging plant extracts is alfalfa root
Knurl extract, stalwart mugwort extract, Rhizoma Polygonati extract, the mixture of chervil extract.
7. anti-apolexis composition as claimed in claim 6, it is characterised in that the alfalfa root nodule extract, stalwart mugwort carry
The weight ratio for taking thing, Rhizoma Polygonati extract, chervil extract is：Alfalfa root nodule extract：Stalwart mugwort extract：Sealwort extracts
Thing：Chervil extract=(1-10)：(1-10)：(1-10)：(1-10).
8. anti-apolexis composition as claimed in claim 7, it is characterised in that the alfalfa root nodule extract, stalwart mugwort carry
The weight ratio for taking thing, Rhizoma Polygonati extract, chervil extract is：Alfalfa root nodule extract：Stalwart mugwort extract：Sealwort extracts
Thing：Chervil extract=(2-3)：(3-5)：(3-5)：(4-6).
A kind of 9. cosmetics for including the composition as described in any one of claim 1~8.
10. cosmetics as claimed in claim 9, it is characterised in that matter of the anti-apolexis composition in the cosmetics
Amount percentage composition is 0.5-10%.
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| CN107802540B (en) | 2020-04-07 |
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