CN106038385A - Cosmetic composition capable of stimulating collagen generation for wrinkle resistance - Google Patents
Cosmetic composition capable of stimulating collagen generation for wrinkle resistance Download PDFInfo
- Publication number
- CN106038385A CN106038385A CN201610402399.5A CN201610402399A CN106038385A CN 106038385 A CN106038385 A CN 106038385A CN 201610402399 A CN201610402399 A CN 201610402399A CN 106038385 A CN106038385 A CN 106038385A
- Authority
- CN
- China
- Prior art keywords
- cosmetic composition
- wrinkle
- opposing
- benzyl amide
- france
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses cosmetic composition capable of stimulating collagen generation for wrinkle resistance. Active components of the cosmetic composition comprise a Helichrysum stoechas extract, palmitoyl tripeptide-5 and dipeptide diaminobutyroyl benzylamide diacetate. The active components of the cosmetic composition comprise a natural plant extracting solution and small-molecular peptide active additives, the components are reasonably combined and matched for common use, and collagen generation is stimulated in various ways, so that the effect of resisting skin wrinkles is achieved.
Description
Technical field
The invention belongs to cosmetic composition technical field, be specifically related to a kind of stimulation collagen and generate opposing wrinkle
Cosmetic composition.
Background technology
Aging is a kind of physiological phenomenon, and physiologically performance is exactly the deterioration of each organ, causes various ageing disorders
Generation.And the i.e. skin of evidence the most intuitively is aging.The approach of anti-aging cosmetics defying age in the market mainly collects
In at three big aspects: (1) remove excess reactive oxygen free radical；(2) cell metabolism is promoted；(3) supplement in skin
The elastin laminin of collagen protein.Although this three big approach can solve most of problem of ageing skin, but along with people's
Research, finds that to cause skin aging reason be various and the aging to skin often of these numerous reasons plays solely
From the most each reason of effect can cause the aging of skin.So, when developing anti-aging product, skin to be considered declines
Old reason, acts on from multipath simultaneously, can be only achieved more preferably anti-aging effects.But it is anti-ageing to take multipath effect
Always, it is necessary to consider safety, otherwise skin can be produced serious injury simultaneously, the most not only can not defying age, accelerate on the contrary
Skin aging.
Summary of the invention
It is an object of the invention to provide a kind of stimulation collagen and generate the cosmetic composition of opposing wrinkle, this cosmetic
The active component of product compositions includes natural botanical extraction liquid, small-molecule peptide active additive, utilizes reasonable group of various composition
Close, cooperation shares, and is generated by number of ways stimulation collagen thus reaches to resist effect of skin wrinkle.
The above-mentioned purpose of the present invention is achieved through the following technical solutions: a kind of stimulation collagen generates opposing wrinkle
The cosmetic composition of stricture of vagina, the active component of this cosmetic composition includes France Helichrysum extract, palmityl tripeptides-5 and two
Peptide diaminobutyryl benzyl amide diacetin.
The present invention selects natural botanical extraction liquid France Helichrysum extract, small-molecule peptide active additive to combine one
Rise, in the way of combination and cooperation, the reason causing skin aging is intercepted, strengthen the natural cover of skin, strengthen skin pair
The opposing of environmental stimuli, thus reach safe and effective anti-aging effects, have very important significance.
As a kind of preferably technical scheme of the present invention, this cosmetic composition is by the component of following weight/mass percentage composition
Make:
France's Helichrysum extract 0.5 ~ 3.0%
Palmityl tripeptides-5 0.5 ~ 3.0%
Dipeptides diaminobutyryl benzyl amide diacetin 0.5 ~ 4.0%
Surplus is one or more in conventional substrate, deionized water, purified water and the distilled water of cosmetics exterior-applied formulation.
In this cosmetic composition:
Described France Helichrysum extract is commercially available prod, it is preferred that its solid content is preferably 15 ~ 23g/L.
This France's Helichrysum extract preferably refers to be extracted by extraction process from the Helichrysum of France's South Atlantic Ocean bank
Active component, rich in few candy in this Helichrysum.
French Helichrysum extract in the present invention, Compositae wax belongs to, and latin name is HELICHRYSUM STOECHAS.France works as
Ground has another name called immortality flower, and the long seashore rock at Europe South Atlantic Coast line and the harsh and unforgiving environments of gravel, the big florescence is from June to 7
Month, still it is connected on plant after flower is withered, will never fade, therefore claimed " immortal ".Its contained oligosaccharide can compensate because of
The periostin synthesis that aging causes reduces and maintains extra-cellular matrix structure, and in corium, the structure of fiber is improved, thus
Recover skin elasticity and make wrinkle reduce periostin by substantial amounts of fibrocyte expression tightness degree.On skin, periosteum
The sensible substantial amounts of fibrocyte of albumen expresses tightness degree.It is found to be present in dermal epidermal junction layer, papillary dermis and hair
Capsule.In the dermis, periostin participates in formation and the ripening of collagen fiber, it is thus ensured that suitable mechanics usefulness.Additionally, bone
Memebrane protein is also bound to the integration of cell surface, and periostin can regulate cellular activity, beneficially cell migration, propagation and
Differentiation.It is the regenerated protein of a kind of strength, and makes the integrity and protection antagonism mechanical pressure maintaining cell tissue
New contribution.Periostin follows following mechanism of action for the structure of collagen fiber: some research display periostin promote
Entering the activity of lipoxygenase (LOX), this enzyme participates in collagen cross-linking；Other research display periostin as I-type collagen,
Connection molecule between collagen type v albumen and fibronectin, can ensure that the lateral connection of collagen fiber；Finally, based on it to glue
Directly affecting of original structure, periostin can also regulate and control its sensitivity to protect fibre by protease such as metalloproteases (MMP)
Dimension.Therefore, France's Helichrysum extract can reconstructed collagen fiber, improve dermal matrix density, increase skin mechanics performance, reduce face
Portion's cutis laxa.
As the present invention one preferred embodiment, the described glycerol that palmityl tripeptides-5 is palmityl tripeptides-5
Aqueous solution.
Preferably every L glycerol aqueous solution is about 1000mg containing palmityl tripeptides-5.
Herein in regard to the glycerine water solution that palmityl tripeptides-5 is palmitic acid acyl tripeptides-5, only palmityl tripeptides-5 one of which
Enumerating of application, not for limiting.
Palmityl tripeptides-5 is commercially available prod, derive from synthesis, purify, sequence be Petiolus Trachycarpi-lysine-valine-rely
Propylhomoserin-hydroxyl (Palm-Lys-Val-Lys-OH).By Palmic acid with tripeptides covalent bond to carry when local skin is applied
The bioavailability of high tripeptides and permeability.The effect of palmityl tripeptides-5 derives from imitation thrombospondin-1(TSP-1)
Activity, thrombospondin-1(TSP-1) be important activation for potential tissue growth factor-β (TGF-β) in skin
Agent.In skin, TGF-β is ECM(extracellular matrix) main regulatory factors.TGF-β is considered to stimulate skin corium fibroblast
The multiple proteins such as dimension smooth muscle cells collagen synthesis albumen, collagen protein is the main component of skin corium ECM.The most especially to determine skin
Intensity and elastic I-type collagen (80-85%) and type III collagen protein (10-15%) are the most obvious, and they are to Elastic tissue
Generate, to hyaluronic acid and the synthesis of other Dan Baiduotang proteoglycan PG necessary to electrolyte regulation and control, water tariff collection and some other processes
Play an important role.Additionally, TGF-β also can trigger layer Fibronectin V, IV collagen type and VII collagen type etc. be present in
The synthesis of these constituents at dermal epidermal junction.Except structure function, TGF-β resists the substrate that can make protein degradation
The expression of metalloproteases (MMP).Therefore keep TGF-β signal be in good poised state contribute to skin be in healthy and
Stable state, this is most important to the holding of youth appearance.Therefore palmityl tripeptides-5 is based on regenerative system (synthesis base
Matter albumen) and the common effect of protection mechanism (suppression MMP and the expression of proinflammatory cytokine) these two aspects, to reach opposing wrinkle
The effect of stricture of vagina.
As the present invention one preferred embodiment, described dipeptides diaminobutyryl benzyl amide diacetin is excellent
Elect the glycerine water solution of dipeptides diaminobutyryl benzyl amide diacetin as.
Preferably every L glycerol aqueous solution is about 2500 mg containing dipeptides diaminobutyryl benzyl amide diacetin.
It is preferably dipeptides diaminobutyryl benzyl amide two herein in regard to dipeptides diaminobutyryl benzyl amide diacetin
Enumerating, not of the glycerine water solution of acetate, the only application of dipeptides diaminobutyryl benzyl amide diacetin one of which
For limiting.
Dipeptides diaminobutyryl benzyl amide diacetin is little molecule tripeptides, for commercially available prod, be typically derived from synthesis,
Purify.The wrinkle caused by facial expression always can be it is obvious that after facial movement is excessively frequently, these expression stricture of vaginas can become
Permanent deep forehead stricture of vagina, decree stricture of vagina and crows-feet, in addition to injection for curing, must have for safely and effectively improving wrinkle
The product demand of stricture of vagina.Its mechanism is inspired by naturally, and activity has imitated the protein found in mausoleum Pallas pit viper (Wa Shi Agkistrodon halys) venom
The activity of Waglerin-1, Waglerin-1 has the activity of the strongest minimizing muscle contraction.Its binding mode is mainly: block
Neurotransmission on acetylcholinergic receptor, thus immediately and longer loosen pseudo wrinkle.This little molecule tripeptides is muscle
A kind of antagonist of nicotinic acetycholine membrane receptor (mnACHR).Because muscle nicotinic acetycholine membrane receptor is closed, ion
Passage remains turned-off.Absorbing without Na+, muscle cell keeps loosening, and the Nerve impulse being delivered to muscle is resisted, and facial muscle are protected
Hold and loosen.Therefore can be effective against wrinkle, be particularly well-suited to, except expression stricture of vagina, smooth wrinkle, help to loosen facial muscle, simultaneously
Do not affect various facial expression.
It is multiple that the dosage form of cosmetic composition of the present invention is preferably cream shape, emulsion form, gel or water preparation shape etc.
The dosage form that can be accepted.
The invention have the advantages that the cosmetic composition of stimulation collagen of the present invention generation opposing wrinkle contains energy
Recover the synthesis of main regeneration albumen (periostin), the French Helichrysum extract of reconstructed collagen fiber, (close based on regenerative system
Become stromatin) and defying age palmityl tripeptides-5 of protection mechanism (resisting MMP and the expression of proinflammatory cytokine), based on pressing down
Acetylcholinergic receptor processed reaches relaxed muscle and resists the dipeptides diaminobutyryl benzyl amide diacetin of expression wrinkle, three kinds
Active component synergism can generate by stimulation collagen, reaches to resist effect of wrinkle.
Accompanying drawing explanation
Fig. 1 is keratodermatitis water content test figure in embodiment 7；
Fig. 2 is that in embodiment 7, skin coarseness improves result figure, before wherein a is use, after b is use；
Fig. 3 is that in embodiment 7, canthus fishtail line improves result figure, before the most left figure is use, after right figure is use.
Detailed description of the invention
The stimulation collagen that the present invention provides generates the cosmetic composition of opposing wrinkle, and this cosmetic composition has
Outer opposing expression stricture of vagina, the effect generating internal stimulus collagen, albumen, with France Helichrysum extract, palmityl tripeptides-5, dipeptides two
Aminobutyryl benzyl amide diacetin is chief active additive, and add cosmetics commonly use matrix components emulsifying agent, oils and fats,
One or more in wetting agent, thickening agent, preservative, essence, deionized water, purified water and distilled water are made.
Embodiment 1
Anti-wrinkle cream:
The component and the weight/mass percentage composition thereof that form above-mentioned anti-wrinkle cream be:
Oil phase:
MONTANOV 68(spermol, cetearyl glucoside) 4.00
SIMULSOL 165 1.00
Jojoba oil 2.00
Parleam 8.00
Tocopherol acetas 1.00
Polydimethylsiloxane 2.00
Aqueous phase:
Deionized water surplus
Glycerol 4.00
Butanediol 4.00
HANSHENGJIAO 0.20
Carbomer 0.20
Allantoin 0.20
After emulsifying, high temperature adds:
Triethanolamine 0.20
Deionized water 1.80
After emulsifying, low temperature adds:
France's Helichrysum extract 2.00
Palmityl tripeptides-5 1.50
Dipeptides diaminobutyryl benzyl amide diacetin 3.00
Preservative qs
Essence is appropriate.
After oil phase, aqueous phase are heated separately to 75 DEG C, two-phase mixtures homogenizing several minutes, adding weight/mass percentage composition is 10%
Triethanolamine aqueous solution, stir, stirring cooling, cool to 45 DEG C add France Helichrysum extracts, palmityl tripeptides-5,
Dipeptides diaminobutyryl benzyl amide diacetin, preservative (preservative commonly used in the art), (this area routine makes essence
With essence), stir, after 35 DEG C of placements, become the fine and smooth uniform mastic of white.
France's Helichrysum extract is the ETERNALINE of Qian Laibo (SILAB) company of commercially available France ®, France's Helichrysum extracts
The solid content of thing is 15 ~ 23g/L, the most only enumerates, not for limiting.
Palmityl tripeptides-5 is the SYN of commercially available Switzerland DSM (DSM) company® -COLL.Palmityl tripeptides-5 is Petiolus Trachycarpi
The glycerine water solution of acyl tripeptides-5, containing palmityl tripeptides-5 about 1000mg in every L glycerol aqueous solution, it is not limited to brown
The glycerine water solution of palmitic acid acyl tripeptides-5, the most only enumerates, not for limiting.
Dipeptides diaminobutyryl benzyl amide diacetin is the SYN of commercially available Switzerland DSM (DSM) company ® -AKE.Two
Peptide diaminobutyryl benzyl amide diacetin is the glycerine water solution of dipeptides diaminobutyryl benzyl amide diacetin, every L
Containing dipeptides diaminobutyryl benzyl amide diacetin 2500mg in glycerine water solution, it is not limited to dipeptides diaminourea fourth
The glycerine water solution of acyl benzyl amide diacetin, the most only enumerates.
Embodiment 2
Anti-wrinkle emulsion:
The component and the weight/mass percentage composition thereof that form above-mentioned anti-wrinkle emulsion be:
Oil phase:
MONTANOV 68(spermol, cetearyl glucoside) 3.00
SIMULSOL 165 0.70
Jojoba oil 1.00
Parleam 5.00
Tocopherol acetas 1.00
Polydimethylsiloxane 2.00
Aqueous phase:
Deionized water surplus
Glycerol 4.00
Butanediol 4.00
HANSHENGJIAO 0.20
Allantoin 0.20
After emulsifying, low temperature adds:
France's Helichrysum extract 1.50
Palmityl tripeptides-5 2.00
Dipeptides diaminobutyryl benzyl amide diacetin 4.00
Preservative qs
Essence is appropriate
After oil phase, aqueous phase are heated separately to 75 DEG C, two-phase mixtures homogenizing several minutes, stirring cooling, cool to 45 DEG C of addition methods
State's Helichrysum extract, palmityl tripeptides-5, dipeptides diaminobutyryl benzyl amide diacetin, preservative, essence, stirring is all
Even, become the fine and smooth uniform emulsion of white after 35 DEG C of placements.
Embodiment 3
Crease-resistant gel
The component and the weight/mass percentage composition thereof that form above-mentioned crease-resistant gel be:
Deionized water surplus
Carbomer 0.35
Triethanolamine 0.35
Butanediol 5.00
France's Helichrysum extract 1.50
Palmityl tripeptides-5 1.50
Dipeptides diaminobutyryl benzyl amide diacetin 3.00
Preservative qs
The preparation method of above-mentioned crease-resistant gel products, comprises the following steps:
(1) being mixed with butanediol, deionized water by carbomer, stirring makes it dissolve, and obtains carbomer butanediol solution；
(2) solution becoming weight/mass percentage composition to be 10% triethanolamine water dissolution；
(3) triethanolamine solution prepared is added carbomer butanediol solution, stirring while adding, i.e. obtain after stirring
Bright gel-type vehicle；
(4) by France's Helichrysum extract, palmityl tripeptides-5, dipeptides diaminobutyryl benzyl amide diacetin, preservative with
Gel-type vehicle mixing and stirring, deionized water adds to full dose；
(5) above-mentioned gel is tested, qualified after, then carry out fill and i.e. obtain crease-resistant gel skin care item.
Embodiment 4
Crease-resistant cosmetic water
The component and the relative content thereof that form above-mentioned crease-resistant cosmetic water be:
Deionized water surplus
Butanediol 5.00
France's Helichrysum extract 1.00
Palmityl tripeptides-5 1.00
Dipeptides diaminobutyryl benzyl amide diacetin 2.00
Preservative qs
The preparation method of above-mentioned crease-resistant cosmetic water product, comprises the following steps:
(1) by France's Helichrysum extract, palmityl tripeptides-5, dipeptides diaminobutyryl benzyl amide diacetin, preservative with
Water mixing and stirring；
(2) above-mentioned cosmetic water is tested, qualified after, then carry out fill and i.e. obtain crease-resistant cosmetic water skin care item.
Embodiment 5
Re-surface intensive wrinkle correct
The component and the relative content thereof that form above-mentioned re-surface intensive wrinkle correct be:
Deionized water surplus
HANSHENGJIAO 0.30
Butanediol 5.00
France's Helichrysum extract 3.00
Palmityl tripeptides-5 2.00
Dipeptides diaminobutyryl benzyl amide diacetin 4.00
Preservative qs
The preparation method of above-mentioned re-surface intensive wrinkle correct product, comprises the following steps:
(1) HANSHENGJIAO being mixed with butanediol, deionized water, stirring makes it dissolve；
(2) France Helichrysum extract, palmityl tripeptides-5, dipeptides diaminobutyryl benzyl amide diacetin, preservative are added,
Mixing and stirring；
(3) above-mentioned elite is tested, qualified after, then carry out fill and i.e. obtain re-surface intensive wrinkle correct skin care item.
Embodiment 6
Re-surface intensive wrinkle correct
The component and the relative content thereof that form above-mentioned re-surface intensive wrinkle correct be:
Deionized water surplus
HANSHENGJIAO 0.30
Butanediol 5.00
France's Helichrysum extract 0.5
Palmityl tripeptides-5 0.5
Dipeptides diaminobutyryl benzyl amide diacetin 0.5
Preservative qs
The preparation method of above-mentioned re-surface intensive wrinkle correct product, comprises the following steps:
(1) HANSHENGJIAO being mixed with butanediol, deionized water, stirring makes it dissolve；
(2) France Helichrysum extract, palmityl tripeptides-5, dipeptides diaminobutyryl benzyl amide diacetin, preservative are added,
Mixing and stirring；
(3) above-mentioned elite is tested, qualified after, then carry out fill and i.e. obtain re-surface intensive wrinkle correct skin care item.
Embodiment 7
Observation on probation
Anti-wrinkle cosmetic and control sample prepared by the employing present invention carry out observation of curative effect
Sample: embodiment 5
Control sample: by the French Helichrysum extract in embodiment 5, dipeptides diaminobutyryl benzyl amide diacetin, palmityl
Tripeptides-5 removes
1, skin elasticity test
Test method: volunteer 30 people, before smearing sample, experimenter uses identical gentle cleaning agent to clean face, is being subject to
Shi Zhe face left and right sides symmetric position selectes about 5 × 5cm2The region of size, as Experimental Area, is smeared about on the left of face
The anti-wrinkle cosmetic of 0.5g embodiment 5, smears the control sample of equivalent on the right side of face, and using frequency is that the morning and evening is each the most once, continuously
Every day uses, it is to avoid atmospheric exposure.
Before using the anti-wrinkle cosmetic of the present invention, detect each test portion at test zone skin elasticity tester
The elastic n in position0Value, is repeated 5 times respectively, draws meansigma methods；
Smearing 1, detecting the most respectively at these positions after 2,3,4,5,6 weeks, each test zone respectively detects 5 hypoelasticity n values,
And obtain the meansigma methods of these 5 n values of period.
In order to preferably evaluate the data obtained, by the n meansigma methods that detects every time divided by the n not using sample0Meansigma methods obtains
To the elastic grading at this position, when elasticity grading is the biggest, illustrate that sample increases skin elasticity.
After experimenter uses control sample six weeks, elastic grading value is increased to 1.19 by 1, anti-wrinkle cosmetic elasticity grading value by
1 increases to 1.46, and skin elasticity is remarkably reinforced.As shown in table 1:
Table 1 control sample and the elastic grading table of test specimen
| Time (all) | 0 | 1 | 2 | 3 | 4 | 5 | 6 |
| Embodiment 5 | 1.00 | 1.13 | 1.28 | 1.39 | 1.43 | 1.45 | 1.46 |
| Control sample | 1.00 | 1.03 | 1.05 | 1.12 | 1.14 | 1.17 | 1.19 |
2, moisture retention test:
Volunteer 30 people, respectively at right-hand man inner forearm labelling 4 × 4cm2Pilot region, same arm 2 districts of labelling simultaneously
Territory, interregional every 2cm.Moisture of skin tester is used to carry out the measurement of tested region and control zone, the parallel survey in each region
Fixed 3 times.First measure the blank value of each test zone, then by 2.0 ± 0.1mg sample/cm2Consumption, use latex finger cot will
Sample is spread evenly across in trial zone.Smear the moisture content of skin measuring tested region and blank region for 28 days respectively.
Human detection result shows: using cosmetics of the present invention and control sample after 4 weeks, the test of keratodermatitis water content is tied
Fruit shows, cosmetics of the present invention and control sample contrast skin basic water content raising 13.2%, as shown in Figure 1.
3, desalination wrinkle effect
Re-surface intensive wrinkle correct is tried out through 35 people 28 days, the age from 35～50 years old, 35 human faces all have microgroove in various degree, dry stricture of vagina and
Wrinkle and blee are more low and deep.
Using method: every painting 2 times beyond the highest heavens, usage amount is that face is smeared uniformly.
After using 28 days skin start to become to moisten, smooth, recover gloss and elasticity, wherein 28 (82%) consumers senses
Feel that crows-feet has significantly desalination, 25 (71%) consumer sensation wrinkles to have significantly desalination.
4, skin coarseness improves effect
Using cosmetics of the present invention after 4 weeks, skin coarseness test result shows, subjects skin's roughness of 85% reduces, tool
Body is as shown in Figure 2.
5, crows-feet is improved effect
Improvement to crows-feet: after canthus uses cosmetics of the present invention (embodiment 5) 4 weeks, subjects skin's wrinkle of 88% is deep
Degree shoals, and wrinkle reduces, and its result is as it is shown on figure 3, from figure 3, it can be seen that use the cosmetics of the present invention after 4 weeks, skin wrinkles
Stricture of vagina depth shallower, deep wrinkles significantly reduces.
Meanwhile, experimenter's skin of face visual observations, skin becomes ruddy full, microgroove be improved significantly.
Although the present invention is open as above with embodiment, but it is not limited to protection scope of the present invention, any ripe
Know those skilled in the art, in the change made without departing from the spirit and scope of the invention and retouching, all should be belonged to this
Bright protection domain.
Claims (6)
1. stimulation collagen generates a cosmetic composition for opposing wrinkle, it is characterized in that: the work of this cosmetic composition
Property component include France's Helichrysum extract, palmityl tripeptides-5 and dipeptides diaminobutyryl benzyl amide diacetin.
Stimulation collagen the most according to claim 1 generates the cosmetic composition of opposing wrinkle, it is characterized in that this change
Cosmetic compositions is made up of the component of following weight/mass percentage composition:
France's Helichrysum extract 0.5 ~ 3.0%
Palmityl tripeptides-5 0.5 ~ 3.0%
Dipeptides diaminobutyryl benzyl amide diacetin 0.5 ~ 4.0%
Surplus is one or more in conventional substrate, deionized water, purified water and the distilled water of cosmetics exterior-applied formulation.
Stimulation collagen the most according to claim 1 and 2 generates the cosmetic composition of opposing wrinkle, it is characterized in that:
Described France Helichrysum extract is commercially available prod.
Stimulation collagen the most according to claim 1 and 2 generates the cosmetic composition of opposing wrinkle, it is characterized in that:
The described glycerine water solution that palmityl tripeptides-5 is palmityl tripeptides-5.
Stimulation collagen the most according to claim 1 and 2 generates the cosmetic composition of opposing wrinkle, it is characterized in that:
The described glycerol liquor that dipeptides diaminobutyryl benzyl amide diacetin is dipeptides diaminobutyryl benzyl amide diacetin
Solution.
Stimulation collagen the most according to claim 1 and 2 generates the cosmetic composition of opposing wrinkle, it is characterized in that:
The dosage form of described cosmetic composition is cream shape, emulsion form, gel or water preparation shape.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610402399.5A CN106038385A (en) | 2016-06-08 | 2016-06-08 | Cosmetic composition capable of stimulating collagen generation for wrinkle resistance |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610402399.5A CN106038385A (en) | 2016-06-08 | 2016-06-08 | Cosmetic composition capable of stimulating collagen generation for wrinkle resistance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106038385A true CN106038385A (en) | 2016-10-26 |
Family
ID=57169749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610402399.5A Pending CN106038385A (en) | 2016-06-08 | 2016-06-08 | Cosmetic composition capable of stimulating collagen generation for wrinkle resistance |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106038385A (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107582450A (en) * | 2017-09-15 | 2018-01-16 | 广州赛莱拉干细胞科技股份有限公司 | A kind of anti-apolexis composition and the skin care item containing said composition |
| CN107802540A (en) * | 2017-11-29 | 2018-03-16 | 广东芭薇生物科技股份有限公司 | A kind of anti-apolexis composition and its application |
| CN109248138A (en) * | 2018-10-10 | 2019-01-22 | 广州锦同生物科技有限公司 | A kind of anti-wrinkle cosmetic composition and preparation method thereof |
| CN109984952A (en) * | 2017-12-29 | 2019-07-09 | 广州佳洁化妆品有限公司 | A kind of Essence and preparation method of the compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides |
| CN110237006A (en) * | 2019-07-25 | 2019-09-17 | 深圳依云四季文化旅游发展有限公司 | Skin care compositions and facial mask |
| CN110913957A (en) * | 2017-06-29 | 2020-03-24 | M&L实验室 | Cosmetic composition comprising an essential oil of Helichrysum and an extract of oregano |
| CN112675063A (en) * | 2020-12-30 | 2021-04-20 | 王超云 | Skin-tendering anti-wrinkle composition containing PDRN and application thereof |
| CN112807255A (en) * | 2020-03-23 | 2021-05-18 | 上海铮信生物科技有限公司 | Anti-wrinkle composition and application thereof in cosmetics |
| CN113116795A (en) * | 2021-03-19 | 2021-07-16 | 曾启林 | A cosmetic composition for stimulating collagen production and resisting wrinkle |
| CN113768862A (en) * | 2021-10-13 | 2021-12-10 | 广州市科能化妆品科研有限公司 | Anti-wrinkle composition and preparation method and application thereof |
| CN113952248A (en) * | 2021-08-26 | 2022-01-21 | 无限极（中国）有限公司 | Polypeptide composition and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101061134A (en) * | 2004-11-02 | 2007-10-24 | 彭特法姆股份公司 | Novel topical application agents against mimic and age-related wrinkles |
| CN104523449A (en) * | 2015-01-08 | 2015-04-22 | 上海圣婕化妆品有限公司 | Anti-aging polypeptide compound and application thereof |
| CN105147534A (en) * | 2015-08-28 | 2015-12-16 | 深圳市维琪医药研发有限公司 | Polypeptide composition for skin repairing |
-
2016
- 2016-06-08 CN CN201610402399.5A patent/CN106038385A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101061134A (en) * | 2004-11-02 | 2007-10-24 | 彭特法姆股份公司 | Novel topical application agents against mimic and age-related wrinkles |
| CN104523449A (en) * | 2015-01-08 | 2015-04-22 | 上海圣婕化妆品有限公司 | Anti-aging polypeptide compound and application thereof |
| CN105147534A (en) * | 2015-08-28 | 2015-12-16 | 深圳市维琪医药研发有限公司 | Polypeptide composition for skin repairing |
Non-Patent Citations (3)
| Title |
|---|
| JENNIFER: ""Silab’s Eternaline Supports Anti-Aging"", 《HTTPS://WWW.COSMETICSANDTOILETRIES.COM/FORMULATING/CATEGORY/ ANTIAGING/SILABS-ETERNALINE-SUPPORTS-ANTI-AGING-353752811.HTML》 * |
| WULILYB: ""SYN-COLL -inhouse seminar-CN"", 《HTTPS://WENKU.BAIDU.COM /VIEW/DA38DDAE3186BCEB18E8BB73.HTML》 * |
| 我来说两句: "法国研究人员创新生态萃取蜡菊抗衰老成分", 《HTTP://ROLL.SOHU.COM/20130413/N372550048.SHTML》 * |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110913957A (en) * | 2017-06-29 | 2020-03-24 | M&L实验室 | Cosmetic composition comprising an essential oil of Helichrysum and an extract of oregano |
| CN110913957B (en) * | 2017-06-29 | 2022-12-02 | M&L实验室 | Cosmetic composition comprising an essential oil of Helichrysum and an extract of oregano |
| CN107582450A (en) * | 2017-09-15 | 2018-01-16 | 广州赛莱拉干细胞科技股份有限公司 | A kind of anti-apolexis composition and the skin care item containing said composition |
| CN107802540A (en) * | 2017-11-29 | 2018-03-16 | 广东芭薇生物科技股份有限公司 | A kind of anti-apolexis composition and its application |
| CN107802540B (en) * | 2017-11-29 | 2020-04-07 | 广东芭薇生物科技股份有限公司 | Anti-aging composition and application thereof |
| CN109984952A (en) * | 2017-12-29 | 2019-07-09 | 广州佳洁化妆品有限公司 | A kind of Essence and preparation method of the compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides |
| CN109248138A (en) * | 2018-10-10 | 2019-01-22 | 广州锦同生物科技有限公司 | A kind of anti-wrinkle cosmetic composition and preparation method thereof |
| CN110237006A (en) * | 2019-07-25 | 2019-09-17 | 深圳依云四季文化旅游发展有限公司 | Skin care compositions and facial mask |
| CN112807255A (en) * | 2020-03-23 | 2021-05-18 | 上海铮信生物科技有限公司 | Anti-wrinkle composition and application thereof in cosmetics |
| CN112675063A (en) * | 2020-12-30 | 2021-04-20 | 王超云 | Skin-tendering anti-wrinkle composition containing PDRN and application thereof |
| CN113116795A (en) * | 2021-03-19 | 2021-07-16 | 曾启林 | A cosmetic composition for stimulating collagen production and resisting wrinkle |
| CN113952248A (en) * | 2021-08-26 | 2022-01-21 | 无限极（中国）有限公司 | Polypeptide composition and application thereof |
| CN113952248B (en) * | 2021-08-26 | 2023-07-11 | 无限极（中国）有限公司 | Polypeptide composition and application thereof |
| CN113768862A (en) * | 2021-10-13 | 2021-12-10 | 广州市科能化妆品科研有限公司 | Anti-wrinkle composition and preparation method and application thereof |
| CN113768862B (en) * | 2021-10-13 | 2023-10-20 | 广州市科能化妆品科研有限公司 | Anti-wrinkle composition, preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106038385A (en) | Cosmetic composition capable of stimulating collagen generation for wrinkle resistance | |
| CN105125476B (en) | A kind of anti-wrinkle essence and preparation method thereof | |
| CN104666236B (en) | A kind of preserving moisture and protecting skin facial film | |
| CN105878131B (en) | A kind of anti-aging cosmetics composition containing plant cell active matter and polypeptide | |
| ES2285859T3 (en) | COSMETIC OR DERMOFARMACEUTICAL USE OF PEPTIDES FOR THE CICATRIZATION, HYDRATION AND IMPROVEMENT OF THE SKIN ASPECT DURING NATURAL OR ACCELERATED AGING (HELIODERMIA, CONTAMINATION). | |
| US9770404B2 (en) | Cosmetic composition for whitening and improving the resilience of skin | |
| CN106214535A (en) | A kind of can the anti-apolexis composition of activating cell containing sponge micropin | |
| CN106074304B (en) | The anti-aging cosmetics composition with smooth out wrinkles, even skin a kind of of microballoon containing Sodium Hyaluronate and peptide | |
| CN110384645A (en) | A kind of crease-resistant skin conditioning agent, U.S. restructuring compound for the neck and preparation method | |
| CN105078873A (en) | Biological skin protecting composition with tightening and whitening effects | |
| CN107714559A (en) | One kind is without anti-corrosion deep water supplement skin care item | |
| CN103054771A (en) | Ultra-elastic water-locking facial mask essence and preparation method thereof | |
| CN110833516B (en) | Polypeptide composition with moisturizing effect | |
| CN106963688A (en) | It is a kind of containing plant extracts complex polypeptide liposome composition and preparation method thereof and in the application of anti-wrinkle product | |
| CN112353746A (en) | Skin care composition with skin cell regeneration activating effect and face tightening and lifting anti-aging effect and using method | |
| KR20160131387A (en) | Composition for skin care | |
| CN109528592A (en) | Facial mask and preparation method thereof is repaired in a kind of moisturizing whitening | |
| KR20050103903A (en) | Topical composition and methods for treatment of aged or environmentally damaged skin | |
| CN114588061A (en) | Anti-aging and wrinkle-removing composition, preparation method thereof and skin care product | |
| CN103717200A (en) | New lipo-phosphated or lipo-sulphated compound, compositions comprising it and topical uses thereof | |
| CN113368003A (en) | Composition with overnight muscle repairing effect and preparation method and application thereof | |
| CN115518012B (en) | Composition with effects of inhibiting melanin protein and improving black eye and eye pouch and application thereof | |
| CN112043659A (en) | Anti-wrinkle repair essence cream | |
| KR20120058866A (en) | Cosmetic composition biomimetically designed from extracellular matrix for promoting the stemness of adipose-derived stem cell | |
| CN114073645A (en) | A skin care composition containing mineral components and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20170418 Address after: 510623 Tianhe District, Guangzhou, Pearl River Road, No. 2201, room 12, No. 01, No. 02, No. 06 Applicant after: Guangzhou chuangmeishi Enterprise Management Limited Address before: 510623 Tianhe District, Guangzhou, Pearl River Road, No. 12, High German landmark winter Plaza, block H, 2201 Applicant before: Guangzhou Chants Cosmetics Co., Ltd. |
|
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20171017 Address after: 528200, Foshan District, Guangdong City, Nanhai District, Guicheng City, three mountain new town E26 block factory building - workshop 4, third floor, four building Applicant after: Foshan Ao Ao Biotechnology Co., Ltd. Address before: 510623 Tianhe District, Guangzhou, Pearl River Road, No. 2201, room 12, No. 01, No. 02, No. 06 Applicant before: Guangzhou chuangmeishi Enterprise Management Limited |
|
| TA01 | Transfer of patent application right | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161026 |
|
| RJ01 | Rejection of invention patent application after publication |