CN113768862A - Anti-wrinkle composition and preparation method and application thereof - Google Patents
Anti-wrinkle composition and preparation method and application thereof Download PDFInfo
- Publication number
- CN113768862A CN113768862A CN202111194487.8A CN202111194487A CN113768862A CN 113768862 A CN113768862 A CN 113768862A CN 202111194487 A CN202111194487 A CN 202111194487A CN 113768862 A CN113768862 A CN 113768862A
- Authority
- CN
- China
- Prior art keywords
- wrinkle composition
- amount
- wrinkle
- contained
- palmitoyl tripeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention provides an anti-wrinkle composition and a preparation method and application thereof. The anti-wrinkle composition comprises the following components: a Bonnate Spirulina extract; palmitoyl tripeptide-5; dipeptide diaminobutyrylbenzylamide diacetate; the anti-wrinkle composition comprises, by 100% of the total mass of the anti-wrinkle composition, 0.001% -5% of the Bonnate spirulina extract, 0.001% -0.05% of the palmitoyl tripeptide-5, and 0.001% -0.05% of the dipeptide diaminobutyrylbenzyl amide diacetate. The anti-wrinkle composition can improve wrinkle from multiple angles. According to the invention, the Bonnate spirulina extract, the palmitoyl tripeptide-5 and the dipeptide diaminobutyrylbenzyl amide diacetate are compounded, so that the effects of enhancing the skin elasticity and firmness and fading fine wrinkles are obviously better than those of single or simple combination.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to an anti-wrinkle composition and a preparation method and application thereof.
Background
The skin, like other organs, tends to age with increasing age. Skin aging is a normal phenomenon, which is always present from birth, and as a result, in addition to the physiological function of skin, it is most important to change the appearance of human beings. People often judge the age, identity and status of a person by some extrinsic features of the skin and hair. Aging makes human body beautiful and discolored, so the appearance of aging has negative effect on human psychology, and people want to keep the appearance young and youth forever. Preventing and delaying skin aging is an important subject of beauty skin science. Is more affected by exogenous stimuli than other organs, so that skin aging is a result of the combined action of endogenous and exogenous stimuli.
The skin is the largest organ covering the whole body surface, is a protector of internal organs and tissues of the human body, is also an effect organ of the internal organs, spirit and surrounding environment, and plays an important role in the health and beauty of the human body. Anti-aging skin care is one of the main functions of skin care products, and the gene beauty based on modern biotechnology achievements has become a worldwide trend to improve skin quality, delay aging and fade wrinkles from the aspect of skin cell structures.
How to care the skin, restore the skin's moist elasticity, and resist or delay aging as much as possible is a hot spot in the art. On one hand, people can improve the skin state in a way of reasonably adjusting the dietary structure, insisting on drinking more water and the like, eating more fruits, not needing to be tired excessively and the like; on the other hand, it is also important to enhance the daily care and maintenance of the skin.
Therefore, how to develop a skin care composition effective in improving wrinkles becomes a technical problem to be solved urgently.
Disclosure of Invention
Problems to be solved by the invention
In view of the disadvantages of the prior art, for example: the invention discloses a wrinkle-resistant composition, and aims to solve the problems of poor absorption of active ingredients, allergy, unobvious effect, rebound effect and the like.
Furthermore, the invention also provides a preparation method of the anti-wrinkle composition, and the preparation method is simple and feasible, and raw materials are easy to obtain.
Means for solving the problems
The invention provides an anti-wrinkle composition, which comprises the following components:
a Bonnate Spirulina extract;
palmitoyl tripeptide-5;
dipeptide diaminobutyrylbenzylamide diacetate;
the anti-wrinkle composition comprises, by 100% of the total mass of the anti-wrinkle composition, 0.001% -5% of the Bonnate spirulina extract, 0.001% -0.05% of the palmitoyl tripeptide-5, and 0.001% -0.05% of the dipeptide diaminobutyrylbenzyl amide diacetate.
The anti-wrinkle composition according to claim 1, wherein the bofenadine spirulina extract is contained in an amount of 0.001% to 3%, the palmitoyl tripeptide-5 is contained in an amount of 0.001% to 0.04%, and the dipeptide diaminobutyrylbenzylamide diacetate is contained in an amount of 0.001% to 0.04%, based on 100% by mass of the anti-wrinkle composition.
The anti-wrinkle composition according to the present invention comprises 0.001% to 2% of the bofenate spirulina extract, 0.001% to 0.03% of the palmitoyl tripeptide-5, and 0.001% to 0.03% of the dipeptide diaminobutyrylbenzylamide diacetate, based on 100% of the total weight of the anti-wrinkle composition.
The anti-wrinkle composition according to the present invention comprises 0.001% to 1.5% of the bofenate spirulina extract, 0.001% to 0.02% of the palmitoyl tripeptide-5, and 0.001% to 0.02% of the dipeptide diaminobutyrylbenzylamide diacetate, based on 100% of the total weight of the anti-wrinkle composition.
The anti-wrinkle composition further comprises one or more of a humectant, a chelating agent, a preservative and a solvent; the adding amount of the humectant is 1-50% based on 100% of the total mass of the anti-wrinkle composition; the addition amount of the chelating agent is 0.01-1%; the addition amount of the preservative is 0.1-1%, and the addition amount of the solvent is 22-95%.
The anti-wrinkle composition comprises one or more of 1, 3-propylene glycol, pentanediol, hexanediol, sorbitol, glycerol, dipropylene glycol, 1, 3-butanediol, trehalose, xylitol, erythritol, glyceryl polyether-26, beta-glucan, methyl glucitol polyether-20, methyl glucitol polyether-10, erythrulose, biogan-1, betaine, rhamnose, oat beta-glucan, acetyl chitosamine, polyethylene glycols, water-soluble oils and fats, water-soluble silicone oil and sodium hyaluronate.
The anti-wrinkle composition according to the present invention, wherein the chelating agent comprises EDTA-2Na and/or EDTA-4 Na; and/or the preservative is one or the combination of more than two of p-hydroxyacetophenone, phenoxyethanol, chlorphenesin, sorbitan caprylate, benzyl alcohol, benzoic acid, gluconolactone, sodium benzoate, ethylhexyl glycerol, methyl hydroxybenzoate and propyl hydroxybenzoate.
The present invention also provides a method for preparing the anti-wrinkle composition according to the present invention, which includes the step of mixing the components of the anti-wrinkle composition.
The invention also provides the application of the anti-wrinkle composition in the preparation of skin care products; preferably, the skin care product is one of eye cream, eye gel, eye mask, eye essence, eye patch, face cream, face cleanser, skin lotion, essence, skin milk, facial mask, neck cream, freeze-dried powder and sun protection.
The application of the anti-wrinkle composition comprises 1% -90% of the anti-wrinkle composition.
ADVANTAGEOUS EFFECTS OF INVENTION
The anti-wrinkle composition can improve wrinkle from multiple angles. According to the invention, the Bonnate spirulina extract, the palmitoyl tripeptide-5 and the dipeptide diaminobutyrylbenzyl amide diacetate are compounded, so that the effects of enhancing the skin elasticity and firmness and fading fine wrinkles are obviously better than those of single or simple combination.
In addition, the preparation method of the anti-wrinkle composition is simple and feasible, the raw materials are easy to obtain, and the anti-wrinkle composition is suitable for mass production.
The eye care product containing the anti-wrinkle composition prepared by the invention is safe and non-irritant, can effectively improve eye wrinkles, and is suitable for people of all ages.
Detailed Description
The present invention will be described in detail below. The technical features described below are explained based on typical embodiments and specific examples of the present invention, but the present invention is not limited to these embodiments and specific examples.
Furthermore, in the following detailed description, numerous specific details are set forth in order to provide a better understanding of the present invention. It will be understood by those skilled in the art that the present invention may be practiced without some of these specific details. In other instances, methods, means, devices and steps which are well known to those skilled in the art have not been described in detail so as not to obscure the invention.
It should be noted that:
in the present specification, the meaning of "may" or "may" includes both the meaning of performing a certain process and the meaning of not performing a certain process.
In the present specification, the numerical range represented by "numerical value a to numerical value B" means a range including the end point numerical value A, B.
All units used in the present invention are international standard units unless otherwise stated, and numerical values and numerical ranges appearing in the present invention should be understood to include errors allowed in industrial production.
In the present specification, reference to "some particular/preferred embodiments," "other particular/preferred embodiments," "embodiments," and the like, means that a particular element (e.g., feature, property, and/or characteristic) described in connection with the embodiment is included in at least one embodiment described herein, and may or may not be present in other embodiments. In addition, it is to be understood that the described elements may be combined in any suitable manner in the various embodiments.
In the present specification, if "room temperature" or the like appears, the meaning may be "10 to 40 ℃.
<First aspect>
A first aspect of the present invention provides an anti-wrinkle composition comprising the following components:
a Bonnate Spirulina extract;
palmitoyl tripeptide-5;
dipeptide diaminobutyrylbenzylamide diacetate;
the content of the Bonnate spirulina extract is 0.001% -5%, the content of the palmitoyl tripeptide-5 is 0.001% -0.05%, and the content of the dipeptide diaminobutyrylbenzyl amide diacetate is 0.001% -0.05%.
In the invention, the raw materials of each component are mild to human body, safe and non-irritant. The invention uses the combination of the Bonnate spirulina extract, the palmitoyl tripeptide-5 and the dipeptide diaminobutyryl benzylamide diacetate, and the three components play a role in synergy.
Further, in view of the synergistic effect, the bofenadine spirulina extract, the palmitoyl tripeptide-5, and the dipeptide diaminobutyrylbenzylamide diacetate may be present in a mass ratio of 0.1 to 200:0.5 to 50:1, for example: 1 to 180:0.6 to 45:1, 1.5 to 160:0.7 to 40:1, 2 to 140:0.8 to 35:1, 2.5 to 120:0.8 to 30:1, 3 to 100:0.9 to 25:1, 3.5 to 90:1 to 20:1, and the like.
Bonnate spirulina extract
In the present invention, the extract of Bonnate Spirulina belongs to the genus Spirulina of the family Oscillatoriaceae of the order Cyanophyta. Since the 60's of the last century, spirulina was gradually found to have abundant and unique bioactive components and functions. Such as protein, gamma-linolenic acid, phycocyanin, beta-carotene, inositol, spirulina polysaccharide, essential amino acid, vitamin B12 and the like, has various biological activities in the aspects of improving malnutrition, supplementing protein, resisting oxidation, enhancing immunity, improving gastrointestinal functions, reducing blood fat and the like, and becomes a super nutritional and health-care food accepted internationally. The Bolete spirulina extract contains Bolete spirulina polysaccharide, which is an acidic heteropolysaccharide and has good effects in resisting oxidation and repairing DNA damage as important physiologically active substance of spirulina.
In the present invention, the Bonnate Spirulina extract can be obtained by acid extraction. Specifically, the acid agent may be obtained by dissolving an acidic substance in a solvent. The acidic substance and the solvent are not particularly limited in the present invention, and may be those commonly used in the art. For example: the acidic substance can be one or more of sulfuric acid, hydrochloric acid, acetic acid, phosphoric acid, nitric acid, etc.; the solvent may be water or the like. The concentration of the acidic substance in the acid agent is not particularly limited in the present invention, and may be set, for example, 0.1 to 5mol/L, if necessary.
In some specific embodiments, the Bolinate Spirulina powder is placed in acid agent, heated in water bath at 50 deg.C or higher, preferably 50-100 deg.C, and clear solution is collected after a certain time to obtain Bolinate Spirulina total sugar extractive solution.
The collection method of the clear liquid is not particularly limited in the present invention, and a centrifugal separation method may be employed, and the remaining lower layer solid matter may be further extracted by the centrifugal separation method. Specifically, the rotation speed of the centrifugal separation can be 6000-10000r/min, and the centrifugal time can be 5-20 min.
After centrifugation, the method can be repeated again, and the spirulina powder can be repeatedly extracted for 2-5 times to fully obtain the Bonnate spirulina total sugar extract. Then drying the Boleter spirulina total sugar extract to obtain the Boleter spirulina extract.
In the invention, the Bonnate spirulina extract prepared by the preparation method has stronger antioxidation, can restore the elasticity and compactness of skin, and simultaneously has various effects of brightening the skin, thinning wrinkles and the like.
In the present invention, the bofenadine spirulina extract is contained in an amount of 0.001% to 5%, preferably 0.001% to 3%, more preferably 0.001% to 2%, further preferably 0.001% to 1.5%, for example: 0.005%, 0.01%, 0.05%, 0.1%, 0.5%, 1.5%, 2.5%, 3.5%, 4.5%, etc. When the content of the bofenate spirulina extract is less than 0.001%, the corresponding effect cannot be achieved, and when the content of the bofenate spirulina extract is more than 5%, the cost is too high.
Palmitoyl tripeptide-5
Palmitoyl tripeptide-5, belonging to the signal class of peptides, promotes the synthesis of collagen (type i, type ii and type iv) and the production of extracellular matrix proteins by increasing the activity of stromal cells, making the skin look younger and more elastic. Has the property of promoting the synthesis of collagen and elastin in the dermis, and can accelerate the generation of collagen and repair wrinkles; therefore, the palmitoyl tripeptide-5 can help the skin to supplement collagen, improve the elasticity of the face and obviously reduce the wrinkles of the face. Meanwhile, the palmitoyl tripeptide-5 also has the characteristics of enhancing cell activity, increasing the water content of the skin, enhancing the luster of the skin and improving the skin color.
In the present invention, the palmitoyl tripeptide-5 is contained in an amount of 0.001% to 0.05%, preferably 0.001% to 0.04%, more preferably 0.001% to 0.03%, and still more preferably 0.001% to 0.02%, for example: 0.002%, 0.004%, 0.006%, 0.008%, 0.01%, 0.015%, 0.02%, 0.025%, 0.03%, 0.035%, 0.04%, 0.045%, etc. When the content of the palmitoyl tripeptide-5 is less than 0.001%, the corresponding fine grain fading effect cannot be achieved, and when the content of the palmitoyl tripeptide-5 is more than 0.05%, the cost is too high.
Dipeptide Diaminobutyrylbenzylamide diacetate
The dipeptide diaminobutyrylbenzylamide diacetate simulates the function of a botulinum toxin, and the dipeptide diaminobutyrylbenzylamide diacetate can be combined with a muscle nicotinic acetylcholine receptor (mNAChR) to realize local blocking of nerve transmission muscle contraction information, relax facial muscles and achieve the purpose of smoothing fine wrinkles. The peptides have the same application as signal peptides, and are particularly suitable for the parts (canthus, neck lines and facial lines) with concentrated expression muscles.
In the present invention, the dipeptide diaminobutyrylbenzylamide diacetate is contained in an amount of 0.001% to 0.05%, preferably 0.001% to 0.04%, more preferably 0.001% to 0.03%, and still more preferably 0.001% to 0.02%, based on 100% by mass of the total anti-wrinkle composition, for example: 0.002%, 0.004%, 0.006%, 0.008%, 0.01%, 0.015%, 0.02%, 0.025%, 0.03%, 0.035%, 0.04%, 0.045%, etc. When the content of the dipeptide diaminobutyrylbenzylamide diacetate is less than 0.01%, the corresponding anti-wrinkle effect cannot be achieved, and when the content of the dipeptide diaminobutyrylbenzylamide diacetate is more than 0.05%, the cost is too high.
In the invention, three components of the Bonnat spirulina extract, the palmitoyl tripeptide-5 and the dipeptide diaminobutyrylbenzyl amide diacetate are used, which can play a role in synergy, and achieve the effects of fading fine lines, promoting the synthesis of collagen and elastin and resisting oxidation.
Other Components
In the invention, the anti-wrinkle composition further comprises one or more of a humectant, a chelating agent, a preservative, a solvent and the like; the adding amount of the humectant is 1-50% based on 100% of the total mass of the anti-wrinkle composition; the addition amount of the chelating agent is 0.01-1%; the addition amount of the preservative is 0.1-1%, and the addition amount of the solvent is 22-95%.
The anti-wrinkle composition has excellent moisturizing performance on the basis of improving fine lines by adding the humectant. In the invention, the adding amount of the humectant is 1-50%, preferably 1-25%, more preferably 1-20% based on the total mass of the anti-wrinkle composition being 100%; in order to further exert the efficacy of the humectant, the humectant can be added in an amount of 1-18%, 3-16%, 5-14% or 6-12%. For example: may be 2%, 3%, 6%, 8%, 10%, 12%, 15%, 17%, 19%, etc.
Specifically, the humectant comprises one or a combination of more than two of 1, 3-propylene glycol, pentanediol, hexanediol, sorbitol, glycerol, dipropylene glycol, 1, 3-butanediol, trehalose, xylitol, erythritol, glycerol polyether-26, beta-glucan, methyl glucitol polyether-20, methyl glucitol polyether-10, erythrulose, biogum-1, betaine, rhamnose, oat beta-glucan, acetyl chitosamine, polyethylene glycols, water-soluble oil and fat, water-soluble silicone oil and sodium hyaluronate.
Further, in the present invention, as the chelating agent and the preservative, the present invention is not particularly limited, and may be a chelating agent and a preservative commonly used in the art. The addition amount of the chelating agent is 0.01-1%, preferably 0.01-0.1% by taking the total mass of the anti-wrinkle composition as 100%; the addition amount of the preservative is 0.1-1%. For example, the chelating agent includes EDTA-2Na and/or EDTA-4 Na. The antiseptic is one or more of p-hydroxyacetophenone, phenoxyethanol, chlorphenesin, sorbitan caprylate, benzyl alcohol, benzoic acid, gluconolactone, sodium benzoate, ethylhexyl glycerol, methyl hydroxybenzoate, and propyl hydroxybenzoate.
In addition, the solvent used in the present invention is not particularly limited, and may be any solvent available in the art, for example: water, and the like. As water, there may be mentioned some water commonly used in the art, for example: purified water, deionized water, distilled water, double distilled water, ion exchange water, sterile water, ultrapure water and the like. Specifically, the content of the solvent may be 22 to 95%, for example: the amount of solvent added may be 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 75%, 80%, 85%, 90%, etc.
The anti-wrinkle composition disclosed by the invention has various functional components, except that the compound combination of the bofenadine spirulina extract, the palmitoyl tripeptide-5 and the dipeptide diaminobutyrylbenzylamide diacetate is taken as a main functional component, the combination of one or more than two of a humectant, a chelating agent, a preservative and a solvent is also taken as a relevant component, and the anti-wrinkle composition capable of effectively improving fine wrinkles can be prepared as a whole.
The anti-wrinkle composition has the effects of moisturizing, fading fine wrinkles and tightening skin, and the effective ingredients can penetrate into the bottom of eye muscles to care the eye skin.
< second aspect >
A second aspect of the present invention provides a method of preparing an anti-wrinkle composition, including a step of mixing components of the anti-wrinkle composition. The preparation method of the anti-wrinkle composition is simple and feasible, the raw materials are easy to obtain, and the anti-wrinkle composition is suitable for mass production.
In some specific embodiments, the method of preparing the anti-wrinkle composition comprises the steps of:
1) adding the optional humectant, the optional chelating agent, part of the optional preservative and the optional water into an emulsifying pot, heating to 80-85 ℃, and stirring to dissolve;
2) cooling the emulsifying pot to 42-48 deg.C, adding Bonnate Spirulina extract, palmitoyl tripeptide-5, dipeptide diaminobutyrylbenzyl amide diacetate and the rest optionally existing antiseptic, and stirring to obtain the antiwrinkle composition.
Further, the invention also provides an application of the anti-wrinkle composition in preparing skin care products such as anti-wrinkle products; preferably, the skin care product can be one of eye cream, eye gel, eye mask, eye essence, eye patch, face cream, face cleanser, skin lotion, essence, skin milk, facial mask, neck cream, freeze-dried powder, sun-proof powder and the like.
Specifically, the anti-wrinkle composition is added in an amount of 1% to 99% by mass of the total mass of the skin care product, for example: 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, etc.
Further, when the anti-wrinkle product is used as an eye care product, such as eye cream, eye essence, eye gel, etc., the anti-wrinkle composition is added in an amount of 1% to 50% based on the total mass of the eye care product; when the eye care product is an eye mask, an eye patch and the like, the addition amount of the anti-wrinkle composition is 1-20%.
Examples
Embodiments of the present invention will be described in detail below with reference to examples, but those skilled in the art will appreciate that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.
In the examples, the extraction process of the Bonnate Spirulina extract is as follows:
10mg of algae powder is weighed and added with 5mL of 0.5mol/L H2SO4Stirring in 80 deg.C water bath for 0.5h, centrifuging at 8000r/min for 10min, and collecting supernatant. Repeatedly extracting for 3 times, mixing supernatants, diluting to 50mL to obtain total sugar extractive solution, air drying, and drying to obtain Bonnate Spirulina extract.
Examples 1 to 10
The anti-wrinkle compositions of examples 1 to 10 were prepared according to the mass percentages of the components in the following tables 1 to 2.
The preparation method of the anti-wrinkle composition comprises the following steps:
1) adding sterilized deionized water into main pot, adding hyaluronic acid, glycerol, 1, 3-propylene glycol, betaine, EDTA-2NA, and methyl hydroxybenzoate under stirring, heating to 82 deg.C, homogenizing at 3000rpm for 3min, stirring to remove lumps, and keeping the temperature for 20 min.
2) Cooling to 45 deg.C, adding Bonnate Spirulina extract, palmitoyl tripeptide-5, dipeptide diaminobutyrylbenzyl amide diacetate, and phenoxyethanol, stirring, cooling to 35 deg.C, inspecting, and discharging.
Comparative examples 1 to 7
The wrinkle resistant compositions of comparative examples 1 to 7 were prepared according to the preparation methods of examples 1 to 10, based on the mass percentages of the components in table 3 below.
TABLE 1 anti-wrinkle compositions of examples 1-5
TABLE 2 anti-wrinkle compositions of examples 6-10
TABLE 3 anti-wrinkle compositions for comparative examples 1-7
Test for anti-wrinkle Property
The detection method for the anti-wrinkle performance test comprises the following steps:
1.1 subject screening criteria
A healthy female subject between the ages of 20 and 50 years; and the subjects were all non-sensitive vaccinia muscles; the number of people is 85.
1.2 site of use: around the eye
1.3 frequency of use: it is administered 1 time each in the morning and evening, and for 28 days, 0.8g each time.
1.4 test environmental conditions
The temperature is 21 +/-1 ℃, and the relative humidity is 50 +/-5%;
1.5 design of the test
Single blind, random, self-cross-check, face (left/right measurement area selected according to random table)
1.6 details of the evaluation method
The infraorbital prints were analyzed using Primos CR image acquisition and analysis, as shown in table 4 below.
TABLE 4
As can be seen from the results in Table 4, in examples 1 to 10, the number of fine wrinkles tended to improve as the mass percentage of the Boleter spirulina extract, the palmitoyl tripeptide-5, and the dipeptide diaminobutyrylbenzylamide diacetate in the formulation increased. From the example 1 and the comparative examples 1 to 7, the combination and the compounding of the bofenate spirulina extract, the palmitoyl tripeptide-5 and the dipeptide diaminobutyrylbenzyl amide diacetate can achieve the effect obviously superior to that of single or simple combination, and realize the function of reducing fine wrinkles.
Therefore, the use of the composition of the present invention can achieve an effect of improving wrinkles.
The above examples of the present invention are merely examples for clearly illustrating the present invention and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.
Claims (10)
1. An anti-wrinkle composition, comprising the following components:
a Bonnate Spirulina extract;
palmitoyl tripeptide-5;
dipeptide diaminobutyrylbenzylamide diacetate;
the anti-wrinkle composition comprises, by 100% of the total mass of the anti-wrinkle composition, 0.001% -5% of the Bonnate spirulina extract, 0.001% -0.05% of the palmitoyl tripeptide-5, and 0.001% -0.05% of the dipeptide diaminobutyrylbenzyl amide diacetate.
2. The anti-wrinkle composition according to claim 1, wherein the bofenadine spirulina extract is contained in an amount of 0.001% to 3%, the palmitoyl tripeptide-5 is contained in an amount of 0.001% to 0.04%, and the dipeptide diaminobutyrylbenzylamide diacetate is contained in an amount of 0.001% to 0.04%, based on 100% by mass of the anti-wrinkle composition.
3. The anti-wrinkle composition according to claim 1 or 2, wherein the bofenate spirulina extract is contained in an amount of 0.001% to 2%, the palmitoyl tripeptide-5 is contained in an amount of 0.001% to 0.03%, and the dipeptide diaminobutyrylbenzylamide diacetate is contained in an amount of 0.001% to 0.03%, based on 100% by mass of the anti-wrinkle composition.
4. The anti-wrinkle composition according to any one of claims 1 to 3, wherein the Bonnate Spirulina extract is contained in an amount of 0.001% to 1.5%, the palmitoyl tripeptide-5 is contained in an amount of 0.001% to 0.02%, and the dipeptide diaminobutyrylbenzylamide diacetate is contained in an amount of 0.001% to 0.02%, based on 100% by mass of the anti-wrinkle composition.
5. The anti-wrinkle composition according to any one of claims 1 to 4, further comprising one or a combination of two or more of a humectant, a chelating agent, a preservative, and a solvent; the adding amount of the humectant is 1-50% based on 100% of the total mass of the anti-wrinkle composition; the addition amount of the chelating agent is 0.01-1%; the addition amount of the preservative is 0.1-1%, and the addition amount of the solvent is 22-95%.
6. The anti-wrinkle composition according to claim 5, wherein the moisturizer comprises one or a combination of two or more of 1, 3-propanediol, propylene glycol, pentanediol, hexanediol, sorbitol, glycerin, dipropylene glycol, 1, 3-butanediol, trehalose, xylitol, erythritol, glyceryl polyether-26, β -glucan, methyl glucitol polyether-20, methyl glucitol polyether-10, erythrulose, biogum-1, betaine, rhamnose, oat β -glucan, acetyl chitosamine, polyethylene glycols, water-soluble fats and oils, water-soluble silicone oils, and sodium hyaluronate.
7. The anti-wrinkle composition according to claim 5 or 6, wherein the chelating agent comprises EDTA-2Na and/or EDTA-4 Na; and/or the preservative is one or the combination of more than two of p-hydroxyacetophenone, phenoxyethanol, chlorphenesin, sorbitan caprylate, benzyl alcohol, benzoic acid, gluconolactone, sodium benzoate, ethylhexyl glycerol, methyl hydroxybenzoate and propyl hydroxybenzoate.
8. A method of preparing an anti-wrinkle composition according to any one of claims 1-7, comprising the step of mixing the components of the anti-wrinkle composition.
9. Use of an anti-wrinkle composition according to any one of claims 1-7 for the manufacture of a skin care product; preferably, the skin care product is one of eye cream, eye gel, eye mask, eye essence, eye patch, face cream, face cleanser, skin lotion, essence, skin milk, facial mask, neck cream, freeze-dried powder and sun protection.
10. The use according to claim 9, wherein the anti-wrinkle composition is added in an amount of 1% to 90%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111194487.8A CN113768862B (en) | 2021-10-13 | 2021-10-13 | Anti-wrinkle composition, preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111194487.8A CN113768862B (en) | 2021-10-13 | 2021-10-13 | Anti-wrinkle composition, preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113768862A true CN113768862A (en) | 2021-12-10 |
| CN113768862B CN113768862B (en) | 2023-10-20 |
Family
ID=78873097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111194487.8A Active CN113768862B (en) | 2021-10-13 | 2021-10-13 | Anti-wrinkle composition, preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113768862B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117338624A (en) * | 2023-09-25 | 2024-01-05 | 揭阳市嘉胜日用精细化工有限公司 | Mild and absorbable whitening and anti-wrinkle composition |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106038385A (en) * | 2016-06-08 | 2016-10-26 | 广州市创美时美容化妆品有限公司 | Cosmetic composition capable of stimulating collagen generation for wrinkle resistance |
| CN107961208A (en) * | 2017-12-06 | 2018-04-27 | 广州蜜妆生物科技有限公司 | A kind of small molecule modeling face is compacted spraying and preparation method thereof |
| CN108852894A (en) * | 2018-06-13 | 2018-11-23 | 浙江湃肽生物有限公司 | It is a kind of for repairing the polypeptides in combination of whitening wrinkle-removing |
| CN109464342A (en) * | 2018-12-29 | 2019-03-15 | 广州市盛美化妆品有限公司 | A kind of anti-aging Essence and preparation method thereof |
| CN109674683A (en) * | 2019-02-01 | 2019-04-26 | 陈学龙 | A kind of polypeptide skin care compositions without preservative |
-
2021
- 2021-10-13 CN CN202111194487.8A patent/CN113768862B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106038385A (en) * | 2016-06-08 | 2016-10-26 | 广州市创美时美容化妆品有限公司 | Cosmetic composition capable of stimulating collagen generation for wrinkle resistance |
| CN107961208A (en) * | 2017-12-06 | 2018-04-27 | 广州蜜妆生物科技有限公司 | A kind of small molecule modeling face is compacted spraying and preparation method thereof |
| CN108852894A (en) * | 2018-06-13 | 2018-11-23 | 浙江湃肽生物有限公司 | It is a kind of for repairing the polypeptides in combination of whitening wrinkle-removing |
| CN109464342A (en) * | 2018-12-29 | 2019-03-15 | 广州市盛美化妆品有限公司 | A kind of anti-aging Essence and preparation method thereof |
| CN109674683A (en) * | 2019-02-01 | 2019-04-26 | 陈学龙 | A kind of polypeptide skin care compositions without preservative |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117338624A (en) * | 2023-09-25 | 2024-01-05 | 揭阳市嘉胜日用精细化工有限公司 | Mild and absorbable whitening and anti-wrinkle composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113768862B (en) | 2023-10-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021020887A (en) | Enhanced anti-aging cosmetic composition | |
| JP2009234980A (en) | Cosmetic composition incorporating cell growth factor blended with neuraminic acids and placenta | |
| CN106309154A (en) | Skin care substrate with long acting moisturizing and whitening effects and preparation and application of skin care substrate | |
| CN105168054A (en) | Mask capable of supplementing water, whitening and removing wrinkles and preparation method of mask | |
| CN106727020A (en) | Baby's moistening skin-care frost | |
| CN105055251A (en) | Anti-aging cosmetic and preparation method thereof | |
| CN110772463A (en) | Eye skin repair composition and preparation method and application thereof | |
| KR102016164B1 (en) | Whitening emulsion cosmetic composition containing a vitamin tree fruit extract and method for manufacturing the same | |
| CN104473860A (en) | Ganodermalucidumcollagen mask and preparation process thereof | |
| CN113768862B (en) | Anti-wrinkle composition, preparation method and application thereof | |
| CN108392455A (en) | Face cream and preparation method thereof containing dendrobium candidum extract | |
| CN112675047A (en) | Double-layer bath foam and preparation method thereof | |
| CN111388394A (en) | Biphase freeze-dried powder solvent and preparation method and application thereof | |
| CN110859758A (en) | Whitening anti-aging repair type medical cold compress patch and preparation method thereof | |
| CN110585079A (en) | Radiation-resistant composition containing food-borne peptide and radiation-resistant emulsion thereof | |
| CN116327674A (en) | Anti-wrinkle compact micro-nano essence emulsion and preparation method thereof | |
| CN112136997A (en) | Solid beverage with whitening and moisturizing functions and preparation method thereof | |
| CN109481323A (en) | A kind of Aloe original juice moisturizing oil and preparation method thereof | |
| CN109646359B (en) | Rose-agaric mud membrane paste with effects of cleaning, purifying, maintaining beauty and keeping young and preparation method thereof | |
| KR101203394B1 (en) | Scrub cosmetic composition containing shiitake | |
| CN105640836B (en) | A kind of surfactant and preparation method thereof containing lotus active constituent | |
| CN114557938A (en) | Composition with brightening, compacting and anti-wrinkle functions and preparation method and application thereof | |
| CN104257566B (en) | Composition for cosmetics with conditioning action as well as application thereof | |
| CN113876671A (en) | Anti-aging composition containing rape bud extract and preparation method thereof | |
| CN114317651A (en) | Polygonatum sibiricum polypeptide, preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |