CN112353746A

CN112353746A - Skin care composition with skin cell regeneration activating effect and face tightening and lifting anti-aging effect and using method

Info

Publication number: CN112353746A
Application number: CN202011353511.3A
Authority: CN
Inventors: 靳珊; 刘德明; 刘国兵
Original assignee: Jiangsu Meizhiling Business Development Co ltd
Current assignee: Jiangsu Meizhiling Business Development Co ltd
Priority date: 2020-11-27
Filing date: 2020-11-27
Publication date: 2021-02-12

Abstract

The invention belongs to the technical field of beauty cosmetics, and particularly relates to a skin care composition with the effects of activating skin cell regeneration and tightening, lifting and anti-aging of a face. According to the invention, by adding the propolis extract and the polypeptide extraction essence, multiple effects of moisture and nutrients can be provided for the skin, rich nutrients such as collagen and hyaluronic acid of the skin can be supplemented, and the skin is nourished and cared. The anti-aging active ingredients can effectively permeate the skin and stay in the skin for a long time, so that the long-acting anti-aging effect is achieved. The active ingredients of the skin care composition can quickly penetrate into the skin epidermis, so that the instant moisturizing effect is provided for the skin, and meanwhile, the lasting moisturizing effect is brought.

Description

Skin care composition with skin cell regeneration activating effect and face tightening and lifting anti-aging effect and using method

Technical Field

The invention belongs to the technical field of beauty cosmetics, and particularly relates to a skin care composition with the effects of activating skin cell regeneration and tightening and lifting the face to resist aging and a using method thereof.

Background

Aging of skin is a factor of aging skin cell proliferation and metabolism slowing of the body, and the influence of environmental factors is also great. The skin is a natural barrier against the external environment. However, it is inevitably damaged by long-term exposure to the external environment, and the most harmful factors are ultraviolet rays, infrared rays, pollution and smoke. When the skin is exposed to the external environment, the cells can continuously generate free radicals, so that a large amount of free radicals of the face and the body are increased, metalloproteases in the cells are activated, and then collagen crosslinking and association tissues of the skin are damaged and cut off, the collagen cells are cut off by a sharp blade as if the mutual connection belt is cut off, the phenomenon of relaxation and collapse of the face skin is presented, and obvious fine lines and deep lines are generated.

From about 25 years old, the metabolism of the human body is gradually slowed down, the functions of sebaceous glands and sweat glands are gradually degraded, the internal fiber reserves supporting the surface of the skin are gradually exhausted, the outward tension in the skin is continuously reduced, local areas begin to sink, and wrinkles are generated and become more and more obvious.

Studies have shown that the human body is a cellular society consisting of about 60 trillion cells, with 1-2% of cells decaying and 1-2% of cells regenerating every day, but with the lapse of time, after the age of 25 years, the number of decaying cells gradually becomes greater than that of the newly-regenerated cells, and the human begins to enter the aging stage without feeling, as do skin cells. Telomeres are the "life clock" of the human body, and their length directly determines the length of life. Telomeres become shorter and people become older. After ordinary cells are divided and proliferated for about 50 times, cell telomeres cannot be used continuously, and under the action of telomerase, cells can be proliferated and grown without limit, so that the human admirable 'youthful immortal' is realized. Recent medical research finds that telomerase can repair damaged chromosome telomeres, improve the reconstruction capability of collagen fibers, elastic fibers and hyaluronic acid, and achieve the effects of removing wrinkles, tightening and enhancing skin elasticity. The us scientific society has published a statement regarding the discovery of telomerase: the emergence of telomerase, like the discovery of penicillin at first, can increase the average human life by at least 20 years; the Nature journal also teaches: after 30 years of bitter search, telomerase opens a new place which is expected to prolong the life of human beings. The important discovery of telomerase can be said to become a milestone in the fields of human youth perpetuation, skin aging resistance, wrinkle resistance and compactness.

Researches show that the snake-like poison peptide can induce the activity of telomerase to be increased, so that telomeres are not lost due to cell division, and the cell division times are increased.

YScPAKE (snake venom like peptide) is also called snake venom tripeptide, the standard Chinese name is dipeptide diaminobutyryl benzylamide diacetate, the molecular weight is 370.50 daltons, the molecular formula is C19H29N503, the snake venom like peptide is a small peptide simulating the activity of snake venom toxin Waglerin I, clinical tests show that the snake venom peptide can reduce wrinkles by inhibiting muscle contraction, has excellent smooth and rapid wrinkle removing performance, can directly reach the muscle bottom, is used as a signal peptide, simulates the characteristic of nerve paralysis muscle contraction generated after the venom of a snake invades a human body, effectively blocks the signal transmission of muscle contraction, and smoothens various expression lines, static lines, fine lines and smooth skin.

The mode of action of the snake venom peptides is mainly to block nerve signaling at acetylcholine receptors, thereby relaxing the pseudowrinkles instantly and for a long time. The snake venom-like peptide is an antagonist of the muscle nicotinic acetylcholine membrane receptor (mnAChR). Because the muscle nicotinic acetylcholine membrane receptors are blocked, the ion channel remains closed. No Na + uptake and muscle cells remain relaxed. The nerve impulses transmitted to the muscles are suppressed and the facial muscles remain relaxed.

Due to the function of the signal peptide, the snake venom-like peptide has the effects of improving and tightening the skin aging and the facial muscle sagging, and the expression lines are improved and lightened on the premise of not influencing the expression.

The early application of the snake venom-like peptide is that in 2006, Pentapharm of Dusmann Quanzizi, Netherlands, extracts a tripeptide protein from natural snake venom, and the tripeptide protein has the same function of paralysis neurons as botulinum and has a special effect on wrinkle removal. Compared with the botulinum, the invention is safer and more effective, and wins the Swiss science and technology prize in 2006. Pentapharm company is purchased by 100% of the imperial group of the Netherlands in the world of global nutrition supply company in 2007, then the artificial protein similar to snake venom is successfully synthesized by the imperial, and a completely safe and efficient skin-beautifying milestone technology SYV-AKE is creatively created.

The development process of skin care products is the discovery and utilization process of active substances, and more researches, developments and utilization are directed at snake venom-like peptides with wrinkle removing and anti-aging effects. Chinese patent CN106038351A discloses a polypeptide composition for lightening wrinkles, comprising: a polypeptide composition for lightening wrinkles, comprising: and) selecting one or more polypeptides that inhibit acetylcholine release by preventing vesicle fusion with the cell membrane, including but not limited to pentapeptide-18, acetyl hexapeptide-3, acetyl glutamyl heptapeptide-1.

Chinese patent CN108852894A discloses a polypeptide composition for repairing, whitening and removing wrinkles, which is characterized in that the polypeptide composition for repairing, whitening and removing wrinkles comprises the following components in percentage by weight: a repair polypeptide combination (0.001% -0.5%), the supplemental polypeptide combination comprising palmitoyl tetrapeptide-7 and tripeptide-1-copper; a supplemental collagen polypeptide combination (0.001% -0.3%) comprising palmitoyl tripeptide-1, palmitoyl tripeptide-5, palmitoyl pentapeptide-4: wrinkle-removing polypeptide composition (0.001% -0.5%), which comprises acetyl hexapeptide-8, snake venom peptide and melittin; a skin lightening polypeptide combination (0.001% -0.5%), comprising nonapeptide-1, carnosine, tetrapeptide-30; the skin care composition comprises a plurality of small molecule active substances, a plurality of skin care active agents, a plurality of pH regulators and a plurality of auxiliary agents, and the balance of water, wherein the repair polypeptide composition, the collagen polypeptide supplement composition, the wrinkle removing polypeptide composition and the skin brightening polypeptide composition account for 0.001-1% of the total mass.

Chinese patent CN108785186A discloses a multi-skin and skin-beautifying youth essence, which comprises the following components in parts by weight: 70g of water, 0.02g of EDTA disodium, 5g of glycerol, 3g of propylene glycol, 0.08g of xanthan gum, 0.2g of allantoin, 1g of hyaluronic acid, 0.1g of nipagin methyl ester, 0.5g of D-panthenol, 0.2g of oat B-glucan, 0.1g of HPS0, 0.02g of incense, MTIO.1g, 1g of centella asiatica extract, 0.1g of snake venom peptide, 80.1g of hexapeptide, 120.1g of decapeptide, 0.1g of oligopeptide-3 (L.umixyil), 0.1g of oryzanol peptide and 1g of purslane extract. The above patent generally adopts a plurality of active ingredients, and the corresponding skin care product with the efficacy is prepared by simply superposing the known efficacies of the active ingredients. However, active ingredients are prone to failure, and the superposition of a large number of components may affect the efficacy of the active ingredients to some extent.

Chinese patent CN108078876A discloses a hydrogel preparation, which comprises the following components by weight percent: 2-30 wt% of a skin conditioner comprising a snake venom polypeptide as a core component, 5-25 wt% of a humectant, 4-6 wt% of a film forming agent, 0.01-10 wt% of an antioxidant, 0.005-2 wt% of a chelating agent, 0.01-2 wt% of a cooling agent, 0.01-1 wt% of a pH regulator, 0.001-0.5 wt% of a flavoring agent, and the balance deionized water, wherein the snake venom polypeptide is embedded in the hydrogel scaffold structure by crosslinking. The patent can effectively solve the problem that snake venom polypeptide is easily decomposed and damaged by oxidant, reducer, proteolytic enzyme and the like. However, the method is still cumbersome to prepare and the range of application is limited by the gel.

The prior art studies on specific snake venom-like peptides have been in the use stage of their own action, and intensive studies on how to more effectively utilize the active ingredients have been required.

Disclosure of Invention

In order to solve the technical problems, one of the objectives of the present invention is to provide a skin care composition having the effects of activating skin cell regeneration and tightening and lifting face to resist aging, which can effectively improve the skin conditions of face such as lack of water and fine wrinkles, and can achieve a long-lasting anti-aging effect.

The invention also aims to provide a using method of the skin care composition, which can better promote skin absorption and improve skin problems, and the skin is glossy, full, tight and elastic, and is tender and beautiful.

The invention is achieved by the following specific technical means:

a skin care composition with skin cell regeneration activating and face tightening and anti-aging effects comprises lyophilized powder compound and essence liquid compound;

the freeze-dried powder compound comprises the following components: corn (ZEA MAYS) starch, carnosine, oligopeptide-1, sodium alginate, calcium sulfate, pectin, rose (ROSA RUGOSA) bud extract, hydrolyzed red algae extract, propolis extract, deer bone collagen, dipeptide diaminobutyrylbenzyl amide diacetate, hydrolyzed yeast protein, and hyaluronic acid;

the essence liquid compound comprises the following components: water, glycerol, propylene glycol, hydrolyzed pearl, soybean (Glycine MAX) polypeptide, herba Portulacae (Portu-Laca Oleracea) extract, Aloe Barbadensis (Aloe Barbadensis) leaf extract, hydrolyzed red algae extract, propolis extract, deer bone collagen, acetyl hexapeptide-8, palmitoyl pentapeptide-4, dipeptide diaminobutyryl benzylamide diacetate, hydrolyzed yeast protein, hyaluronic acid, and chlorphenesin.

Preferably, the freeze-dried powder compound comprises the following components in proportion:

preferably, the ratio of the components of the essence liquid compound is as follows:

preferably, the skin care composition has a pH of 5.0 to 8.0.

Preferably, the lyophilized powder compound and/or the essence liquid compound further comprise beta-alanyl hydroxy prolyl diamino butyryl benzyl amide.

Preferably, the water in the essence liquid compound is deionized water.

Preferably, the skin care composition further comprises one or more of vitamin a group, vitamin K group, vitamin B group, vitamin E group, vegetable protein, hyaluronic acid, proteoglycan, cysteine, glycine, aspartic acid, alkaloid, uronic acid.

A method for using a skin care composition having skin cell regeneration activating and face tightening and lifting anti-aging effects, comprising the steps of:

s1, cleaning the face with warm water after makeup removal;

s2, taking out a part of the freeze-dried powder compound and a part of the essence liquid compound;

s3, sequentially pouring the freeze-dried powder compound and a part of the essence liquid compound into a mixing bowl, and uniformly stirring clockwise (stirring for more than 60 circles);

s4, uniformly smearing the facial mask mixed with the mixing bowl on the facial skin from bottom to top by using a brush;

s5, standing for 20-30 minutes;

s6, after the facial mask is completely dried, cleaning the facial mask with warm water (about 30 degrees), and then applying a layer of moisturizing facial mask or smearing type moisturizing skin care products.

S7, performing subsequent maintenance, wherein continuous use is recommended to be carried out for more than 3 months, the continuous use is carried out for 3 days at the beginning, one group is carried out every night, and then one group is used at intervals of 3-7 days, or one group is used every 3 days.

Compared with the prior art, the invention has the following beneficial effects:

according to the invention, by adding the propolis extract and the polypeptide extraction essence, multiple effects of moisture and nutrients can be provided for the skin, rich nutrients such as collagen and hyaluronic acid of the skin can be supplemented, and the skin is nourished and cared. The invention has the beauty effects of removing wrinkles, fading wrinkles, firming and resisting aging and improves the anti-aging effect. The anti-aging active ingredients can effectively permeate the skin and stay in the skin for a long time, so that the long-acting anti-aging effect is achieved. The active ingredients of the skin care composition can quickly penetrate into the skin epidermis, so that the instant moisturizing effect is provided for the skin, and meanwhile, the lasting moisturizing effect is brought. The skin-care mask has the advantages that a user who uses the mask for a long time can enjoy elastic, full and tight skin, the skin states such as facial water shortage, fine lines and pores can be effectively improved after the mask is continuously used for more than 3 months, the skin is tight and full, and the skin is glossy, full, tight, elastic, transparent, tender and beautiful.

Detailed Description

Example 1:

Example 2;

The freeze-dried powder compound comprises the following components in proportion:

the essence liquid compound comprises the following components in percentage by weight:

example 3:

example 4:

example 5:

example 6:

the skin care composition has a pH of 5.0-8.0.

Example 7:

the freeze-dried powder compound and/or the essence liquid compound also comprise beta-alanyl hydroxy prolyl diamino butyryl benzylamide.

Example 8:

the water in the essence liquid compound is deionized water.

Example 9:

the skin care composition further comprises one or more of vitamin A group, vitamin K group, vitamin B group, vitamin E group, vegetable protein, hyaluronic acid, proteoglycan, cysteine, glycine, aspartic acid, alkaloid, and uronic acid.

Example 10:

s1, cleaning the face with warm water after makeup removal;

s5, standing for 20-30 minutes;

And (3) testing the efficacy:

the skin care compositions with the effects of activating skin cell regeneration and tightening and resisting aging of the face are used for testing the wrinkle improvement of the skin care compositions of the examples 1-9, the number of the skin care compositions of the examples 1-9 is 90, the skin care compositions are irregularly divided into 9 groups, the age is 25-35 years, the testing time is 3 months, one group is used every 3 days, and other skin improvement products are not used in the period, and the testing results are as follows:

examples	Number of test persons	Time of measurement	The effect is very good	The effect is obvious	General effects	The effect is not obvious
							Example 1	10	3 months old	2	4	3	1
Example 2	10	3 months old	3	3	4	0
							Example 3	10	3 months old	4	3	3	0
Example 4	10	3 months old	3	4	2	1
							Example 5	10	3 months old	2	5	3	0
Example 6	10	3 months old	3	4	3	0
							Example 7	10	3 months old	4	4	2	0
Example 8	10	3 months old	2	5	2	1
							Example 9	10	3 months old	1	6	3	1

Test result representation mode: the test is performed by grouping blind tests, sensory evaluation of testers is collected, and the evaluation grade is divided into 4 grades: first gear: the effect is fine, keep off: obvious effect, three-gear: general effect, fourth gear: the effect is not obvious.

The test data in the table show that the propolis extract and the polypeptide extract essence are added, so that moisture and nutrients can be provided for the skin in multiple effects, rich nutrients such as collagen and hyaluronic acid of the skin can be supplemented, and the skin is nourished and cared. The invention has the beauty effects of removing wrinkles, fading wrinkles, firming and resisting aging and improves the anti-aging effect. The anti-aging active ingredients can effectively permeate the skin and stay in the skin for a long time, so that the long-acting anti-aging effect is achieved. The active ingredients of the skin care composition can quickly penetrate into the skin epidermis, so that the instant moisturizing effect is provided for the skin, and meanwhile, the lasting moisturizing effect is brought. After the facial mask is continuously used for more than 3 months, the skin states of face water shortage, fine lines, pores and the like can be effectively improved, the skin is compact and plump, and the skin is glossy, full, elastic, tender and beautiful.

The technical solutions of the present invention or similar technical solutions designed by those skilled in the art based on the teachings of the technical solutions of the present invention are all within the scope of the present invention to achieve the above technical effects.

Claims

1. A skin care composition having effects of activating skin cell regeneration and facial tightening and lifting anti-aging, characterized in that: comprises a freeze-dried powder compound and an essence liquid compound;

2. The skin care composition with skin cell regeneration activating and face tightening and lifting anti-aging effects as set forth in claim 1, wherein: the freeze-dried powder compound comprises the following components in proportion:

3. the skin care composition with skin cell regeneration activating and face tightening and lifting anti-aging effects as set forth in claim 1, wherein: the essence liquid compound comprises the following components in percentage by weight:

4. the skin care composition with skin cell regeneration activating and face tightening and lifting anti-aging effects as set forth in claim 1, wherein: the freeze-dried powder compound comprises the following components in proportion:

5. the skin care composition with skin cell regeneration activating and face tightening and lifting anti-aging effects as set forth in claim 1, wherein: the essence liquid compound comprises the following components in percentage by weight:

6. the skin care composition with skin cell regeneration activating and face tightening and lifting anti-aging effects as set forth in claim 1, wherein: the skin care composition has a pH of 5.0-8.0.

7. The skin care composition with skin cell regeneration activating and face tightening and lifting anti-aging effects as set forth in claim 1, wherein: the freeze-dried powder compound and/or the essence liquid compound also comprise beta-alanyl hydroxy prolyl diamino butyryl benzylamide.

8. The skin care composition with skin cell regeneration activating and face tightening and lifting anti-aging effects as set forth in claim 1, wherein: the water in the essence liquid compound is deionized water.

9. The skin care composition with skin cell regeneration activating and face tightening and lifting anti-aging effects as set forth in claim 1, wherein: the skin care composition further comprises one or more of vitamin A group, vitamin K group, vitamin B group, vitamin E group, vegetable protein, hyaluronic acid, proteoglycan, cysteine, glycine, aspartic acid, alkaloid, and uronic acid.

10. The method of using the skin care composition having skin cell regeneration-activating efficacy and face tightening and lifting anti-aging effects according to claims 1 to 9, characterized in that: the method comprises the following steps:

s1, cleaning the face with warm water after makeup removal;

s5, standing for 20-30 minutes;