CN109998986A - One kind two splits yeast freeze-dried powder preparation and preparation method thereof - Google Patents
One kind two splits yeast freeze-dried powder preparation and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61Q19/00—Preparations for care of the skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q19/005—Preparations for sensitive skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
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Abstract
The present invention relates to cosmetic technical fields, specifically a kind of two split yeast freeze-dried powder preparation and preparation method thereof, including splitting yeast freeze-dried powder by two, two splitting yeast (daily) lyase liquid and two and split the solution that yeast (ight) lyase liquid constitutes, wherein, two split yeast freeze-dried powder and are made by the component of following quality proportionings: two split yeast tunning lysis object: 2.5-7.5%；Glutathione: 0.05-0.15%；Argireline: 0.25-0.75%；Oligopeptides -1:0.25-0.75%；Oligopeptides -3:0.15-0.45%；Mannitol: 90.4%-96.8%；The two of task of the present invention are to provide the preparation method that one kind two splits yeast freeze-dried powder preparation.
Description
Technical field
The present invention relates to cosmetic technical field, specifically a kind of two split yeast freeze-dried powder preparation and preparation method thereof.
Background technique
Freeze-dried powder: it is the aseptic powder evacuated under vacuum conditions, there are the cosmetic products of repair.Common jelly in the market
Yellow, fine and smooth skin quality that dry powder has whitening to highlight, nti-freckle is dispelled repairs acne print, wrinkle reduction, anti-aging, repairs cuticula, moisturizing lock
Water, anti-ageing reparation and other effects.But the effect of general freeze-dried powder is relatively single, is unable to reach said effect.
Summary of the invention
In order to overcome the above the deficiencies in the prior art, one of task of the invention is to provide one kind two and splits yeast freeze-dried powder system
Agent, the one kind two split the yeast freeze-dried powder preparation difference of the situation according to locating for night skin in the daytime, provide freeze-dried powder and day and night two kinds
Freeze-dried powder lyase liquid, based on freeze-dried powder lyase liquid is mainly repaired with moisturizing in the daytime, night freeze-dried powder lyase liquid has stronger moisturizing
Water lock releives and repairs effect, and there are also repair the antipruritic effect of hormone face, sensitive flesh, antiallergic；The two of task of the present invention are to provide one
Kind two splits the preparation method of yeast freeze-dried powder preparation.
One of task of the present invention is achieved through the following technical solutions:
One kind two splits yeast freeze-dried powder preparation, including splits yeast freeze-dried powder by two, two splits yeast freeze-dried powder (daily) lyase
Liquid and two splits the solution that yeast freeze-dried powder (ight) lyase liquid is constituted, wherein two split yeast freeze-dried powder by following quality proportionings
Component be made:
Two split yeast tunning lysis object: 2.5-7.5%；
Glutathione: 0.05-0.15%；
Argireline: 0.25-0.75%；
Oligopeptides -1:0.25-0.75%；
Oligopeptides -3:0.15-0.45%；
Mannitol: 90.4%-96.8%；
Two in the present invention split yeast tunning lysis object be through Bifidobacterium culture, inactivation and decompose obtain metabolism produce
Object, cytoplasmic fragment, cell-wall components and polysaccharide composite body.With very strong anti-immunity inhibitory activity and DNA can be promoted to repair,
It is can effectively protect skin, not by UV-induced damage, helps the light aging for preventing epidermis and corium.Two, which split yeast fermentation, produces
The molten spore object of object can generate the small molecule including vitamin group, minerals, amino acid etc. beneficial to skin care, be that one kind is served only for skin care
High-quality yeast essence.Its metabolism that can reinforce cuticula, moreover it is possible to capture free radical, inhibit the peroxidating of lipid, there is beauty
White, anti-aging function.The nutriment being wherein rich in has the function of nourishes rough skin.
Glutathione in the present invention has the antioxidant capacity of wide spectrum, can use in anti-ageing skin care；There is the work of skin whitening
With skin arteries and veins brown stain can be inhibited, and can effectively conditioning skin and moisturizing.
Argireline in the present invention is a kind of biologically active polypeptide, which can both reduce existing face wrinkle
Line, and new wrinkle can be effectively prevent to generate.By inhibiting the release of neurotransmitter acetylcholine (acetylcholine),
The contraction of muscle is reduced, to reach the generation for reducing dynamic line, expression line.
Oligopeptides -1 in the present invention is the synthetic peptide of 3 kinds of amino acid such as glycine, histidine and lysine composition, as skin
Skin conditioner uses.
The small molecule that oligopeptides -3 in the present invention is made of 2-6 amino acid, can be directly effectively by the absorption benefit of cell
With, rapid replenishing collagen such as boosts metabolism to play good opsonic action, stimulates cytothesis, be proliferated,
Newborn collagen, effect is slower, but safety is higher.
Mannitol in the present invention is conducive to the conditioning of skin and anti-ageing to the elimination of peroxynitrite, to skin
Skin allergy also has a degree of inhibiting effect；Mannitol can inhibit the light injury and light aging to skin, and have moisturizing function
Energy.
Two split yeast (daily) lyase liquid is made by the component of following quality proportionings:
Glycerol: 1-3%；
Propylene glycol: 1-3%；
Guava (PSIDIUMGUAJAVA) berry extract: 0.6-1.8%；
Reed fragrant plant oil: 1-3%；
Lin Lan profit dew: 0.5-1.5%；
Sodium Hyaluronate: 0.025-0.075%；
Magnolin M:0.075-0.225%；
Hamamelis (HAMAMELISVIRGINIANA) extract: 0.05-0.15%；
Palpus sunglo (USNEABARBATA) extract: 0.05-0.15%；
Curdlan class: 0.025-0.075%；
Hydrolytic collagen: 0.05-0.15%；
Matrixyl -4:0.01-0.03%；
Palmitoyl oligopeptide: 0.01-0.03%；
Fermentation of bacillus product: 0.75-2.25%；
Ceramide: 0.15-0.45%；
1,2- hexylene glycol: 0.25-0.75%；
Parahydroxyacet-ophenone: 0.25-0.75%；
Deionized water: 82.615-94.205%；
Glycerol in the present invention is colourless sweet clear and bright thick liquid, odorless, there is warm sweet taste, can be used as solvent, lubricant,
Medicament and sweetener.
Propylene glycol in the present invention can be used as wetting agent with glycerol or sorbierite cooperation.
Guava (PSIDIUMGUAJAVA) berry extract has good lipoid peroxidization resistant, Ke Yiqi in the present invention
To delaying senility function；Inhibition to xanthine oxidase illustrates there is anti-inflammatory and convergent effect, to B-16 melanocyte
Activity shows strong inhibition, is good cosmetics whitening additive.
The main component glycerol polymethacrylates and Gantrez AN-119 of reed fragrant plant oil, the poly- methyl-prop of glycerol in the present invention
Olefin(e) acid ester makees film forming agent in cosmetics and viscosity control agent uses.Glycerol polymethacrylates is water-soluble clear gel,
It is a kind of transparent, multi-functional moisturizing substrate, can increase skin sense and lubricity, improve moisture retention, prepares transparent, colourless production
Product.Gantrez AN-119 is made antistatic agent, adhesive and emulsion stabilizer in cosmetics and is used.
The main component of the pure profit dew of lily magnolia in the present invention has dendrobium candidum (DENDROBIUMCANDIDUM) extract, library
Drag-line aloe (ALOEBARBADENSIS) leaf extract, kuh-seng (SOPHORAANGUSTIFOLIA) root extract, lycium barbarum
(LYCIUMBARBARUM) berry extract, purple coneflower (ECHINACEAPURPUREA) extract.Dendrobium candidum
(DENDROBIUMCANDIDUM) extract can increase the blood flow of capillary, can be used for the promoting blood circulation of the needs such as hair, anti-ageing
Cosmetics；There is elimination to a variety of free radicals, can be used as antioxidant；There is the function of water suction under the low humidity, has and protect
Wet effect.Aloe barbadensis Miller (ALOEBARBADENSIS) leaf extract has various bioactivity, is important in cosmetics
Adding ingredient.From its to fibrin increase facilitation, the inhibition of elastin laminin, the synthesis of collagen and to from
By the scavenging effect of base, illustrate there is good skin-active, anti-aging effect；There is facilitation to cholesterine synthesis, helps to change
The composition of sebum reduces soft and moist degree that is glossy and increasing skin；Also have the function of antibacterial anti-inflammatory and moisturizing simultaneously.Kuh-seng
(SOPHORAANGUSTIFOLIA) root extract is mainly derived from the root of kuh-seng, and effective component is mainly matrine, is a kind of
Traditional herbal medicine has effects that antibacterial anti-inflammatory for treating eczema and dermatitis；There is facilitation to collagen production,
Also there is facilitation to fibroblastic proliferation, can be used as skin anti-aging；Has effects that moisturizing simultaneously.Lycium barbarum
(LYCIUMBARBARUM) berry extract it have powerful oxidation resistance.The absorbability of its oxyradical is 25,
000 (in contrast blueberry ability 2,500), and it is also rich in calcium, potassium, iron, zinc, selenium, vitamin B and vitamin C.In 1991
One of state studies have shown that the phytochemicals (phytochemicals) in fructus lycii can help prevent O-DNA, restores
Impaired DNA.This shows that it can become the ideal composition in anti-aging product；Purple coneflower (ECHINACEAPURPUREA)
Extract can isolate the triterpene compound of 27 kinds of anti-inflammatory effects, can treat dermatitis, have suppression to the inductivity allergy of skin
Production is used；The resistance of capillary can be enhanced, inhibit capillary permeability and there is anti-inflammatory effect；It can eliminate simultaneously freely
Base has inoxidizability, has and alleviates aging effect；Also there is certain inhibiting effect to melanocyte, so there is certain whitening
The effect of nti-freckle.
The main component of magnolin is Magnolia binodii (MAGNOLIABIONDII) bud/flower extract, wrinkled giant hyssop in the present invention
(AGASTACHERUGOSA) extract, Magnolia binodii (MAGNOLIABIONDII) bud/flower extract can help to reduce subcutaneous
The visibility of capillary reduces black-eyed appearance.Wrinkled giant hyssop (AGASTACHERUGOSA) extract leaves of pulse plants has elimination to free radical
Effect is used as antioxygen anatrophic.
Middle and North America witch hazel (HAMAMELISVIRGINIANA) extract of the present invention makees antioxidant；It being capable of activating cell
Aromatizing enzyme and cathepsin are horizontal to improve cortex local estrogen, enhance skin cell metabolism, there is Antiageing effect,
It can maintain skin elasticity and crease-resistant；With anti-inflammatory, anti-anaphylaxis is releived and convergent effect；There are also good moisture holding capacities simultaneously.
Palpus sunglo (USNEABARBATA) extract is a kind of natural extract from lichens tree in the present invention, wherein leading
Wanting ingredient usnic acid is considered as potent antibiotic and antibacterial agent, can prevent the growth of bacterium and fungi, can be used for deodorization and
It in toothpaste and mouthwash, while being used in cosmetics and personal nursing kind as skin conditioning agent, being cured for wound can be promoted
It closes.
Curdlan has good rheological characteristic in the present invention, has all advantages of xanthan gum, thermal stability is excellent
In xanthan gum.
Hydrolytic collagen is efficient moisture-retention composition, skin-active, inducing tissue regeneration in the present invention, main in human connective tissue
Substance is binded, molecular weight is big, and moisture-retaining capacity more preferably compared with polyalcohols, mainly to support cell, chamfers especially suitable for skin
After matter, skin be in physical therapy made by the most thin stage guarantor.Collagen has good permeability and moisturizing power, is mainly used in
More scar, crease-resistant, pachylosis patient conditioner.Collagen and its hydrolysate compatibility are strong, can be with many functional components
The effect of cooperation is to improve them.
Matrixyl -4 belongs to aging ingredient in the present invention, in the present invention in make skin conditioning agent, antioxidant
It is used with moisturizer.
Palmitoyl oligopeptide makees skin conditioning agent in the present invention and detergent uses.It can promote stromatin
(matrixprotein) the especially synthesis of collagen, while being also possible to increase elastin laminin, hyaluronic acid, glycosaminoglycan
With the generation of fibronectin.
Fermentation of bacillus product is a kind of bacterium that can generate enzyme in the present invention, and produced enzyme can remove skin
Old horn cell.
The main component of ceramide is Caesalpinia spinosaKuntze (CAESALPINIASPINOSA) glue, Cer NP, thorn in the present invention
For mysorethorn (CAESALPINIASPINOSA) glue using Caesalpinia spinosaKuntze as waste, main component is that a kind of galactomannan of neutrality is poly-
Sugar, Cer NP are a kind of lipid matters, and artificial synthesized ingredient, it is close with the structure of matter of keratoderma is constituted, can be very
Skin is penetrated into fastly, is helped the update of skin natural containment, can be promoted the water in the balance and cuticula of nature aquation
In conjunction with forming a kind of reticular structure, lock moisture.
1,2- hexylene glycol is moisturizer in the present invention, belongs to polyalcohol, has fungistatic effect, only when additive amount is 5%
Left and right Shi Caiyou anti-corrosion effect, but it is not equal to preservative.
Sodium Hyaluronate is also known as sodium hyaluronate sodium in the present invention, belongs to skin conditioner, is a kind of acid mucopolysaccharide, naturally deposits
It is in cornea skin, can absorb itself 1000 times of moisture of weight, reaches by retaining moisture of skin, preventing moisture through epidermis
It is lost, and the barrier reparation when skin is damaged, skin is enabled not feel drying after, increase gloss, it can be with
Improve skin-nourishing metabolism, make skin it is soft, it is smooth, go wrinkle, increase elasticity, prevent aging, be good again while moisturizing
Skin penetration enhancer.It is used cooperatively with other nutritional ingredients, the more preferable effect for promoting nutrient absorption can be played.
Parahydroxyacet-ophenone is a kind of natural plant extracts in the present invention, be naturally present in compositae plant artemisia scoparia stem,
Leaf, in the roots of plants such as Artemisia capillaris, Asclepiadaceae plant, kerr tylophora root.With anti-oxidant and effect of releiving multi-functional cosmetic
Product ingredient；In cosmetics, at the same time as the substitute of traditional preservatives, have the function of anti-corrosion synergy, can promote each
Kind preservative efficacy, has excellent stability in height pH and temperature range, can be used for all kinds of formulas, including sun-proof and fragrant
There are good compatibility in wave, it and various cosmetic compositions and packaging material.
Two split yeast (ight) lyase liquid is made by the component of following quality proportionings:
Glycerol: 1-3%；
Propylene glycol: 1-3%；
Guava (PSIDIUMGUAJAVA) berry extract: 0.6-1.8%；
Reed fragrant plant oil: 1-3%；
Starfish branch tube algae (CLADOSIPHONNOVAE-CALEDONIAE) extract: 0.5-1.5%；
Lin Lan profit dew: 0.5-1.5%；
Sodium Hyaluronate: 0.025-0.075%；
Magnolin M:0.075-0.225%；
Hamamelis (HAMAMELISVIRGINIANA) extract: 0.05-0.15%；
Palpus sunglo (USNEABARBATA) extract: 0.05-0.15%；
Curdlan class: 0.025-0.075%；
Hydrolytic collagen: 0.05-0.15%；
Matrixyl -4:0.01-0.03%；
Palmitoyl oligopeptide: 0.01-0.03%；
Fermentation of bacillus product: 0.75-2.25%；
Ceramide: 0.15-0.45%；
Dipotassium glycyrrhizinate: 0.05-0.15%；
Bisabolol: 0.025-0.075%；
Biological carbohydrate gum -1:0.25-0.75%；
1,2- hexylene glycol: 0.25-0.75%；
Parahydroxyacet-ophenone: 0.25-0.75%；
Deionized water: 80.14-93.38%；
Glycerol in the present invention is colourless sweet clear and bright thick liquid, odorless, there is warm sweet taste, can be used as solvent, lubricant,
Medicament and sweetener.
Propylene glycol in the present invention can be used as wetting agent with glycerol or sorbierite cooperation.
Guava (PSIDIUMGUAJAVA) berry extract has good lipoid peroxidization resistant, Ke Yiqi in the present invention
To delaying senility function；Inhibition to xanthine oxidase illustrates there is anti-inflammatory and convergent effect, to B-16 melanocyte
Activity shows strong inhibition, is good cosmetics whitening additive.
The main component glycerol polymethacrylates and Gantrez AN-119 of reed fragrant plant oil, the poly- methyl-prop of glycerol in the present invention
Olefin(e) acid ester makees film forming agent in cosmetics and viscosity control agent uses.Glycerol polymethacrylates is water-soluble clear gel,
It is a kind of transparent, multi-functional moisturizing substrate, can increase skin sense and lubricity, improve moisture retention, prepares transparent, colourless production
Product.Gantrez AN-119 is made antistatic agent, adhesive and emulsion stabilizer in cosmetics and is used.
Starfish branch tube algae extract has inhibition to prolyl endopeptidase in the present invention, and to adjusting, angiotensins, nerve are tight
Zhang Suyou benefit, illustrates have the function of releiving, and in conjunction with its inoxidizability, can be used for skin maintenance；Hyaluronidase has inhibition
Effect, can be effectively suppressed the decomposition of hyaluronic acid, thus have skin moisture-keeping effect
The main component of the pure profit dew of lily magnolia in the present invention has dendrobium candidum (DENDROBIUMCANDIDUM) extract, library
Drag-line aloe (ALOEBARBADENSIS) leaf extract, kuh-seng (SOPHORAANGUSTIFOLIA) root extract, lycium barbarum
(LYCIUMBARBARUM) berry extract, purple coneflower (ECHINACEAPURPUREA) extract.Dendrobium candidum
(DENDROBIUMCANDIDUM) extract can increase the blood flow of capillary, can be used for the promoting blood circulation of the needs such as hair, anti-ageing
Cosmetics；There is elimination to a variety of free radicals, can be used as antioxidant；There is the function of water suction under the low humidity, has and protect
Wet effect.Aloe barbadensis Miller (ALOEBARBADENSIS) leaf extract has various bioactivity, is important in cosmetics
Adding ingredient.From its to fibrin increase facilitation, the inhibition of elastin laminin, the synthesis of collagen and to from
By the scavenging effect of base, illustrate there is good skin-active, anti-aging effect；There is facilitation to cholesterine synthesis, helps to change
The composition of sebum reduces soft and moist degree that is glossy and increasing skin；Also have the function of antibacterial anti-inflammatory and moisturizing simultaneously.Kuh-seng
(SOPHORAANGUSTIFOLIA) root extract is mainly derived from the root of kuh-seng, and effective component is mainly matrine, is a kind of
Traditional herbal medicine.For treating eczema and dermatitis, has effects that antibacterial anti-inflammatory；There is facilitation to collagen production,
Also there is facilitation to fibroblastic proliferation, can be used as skin anti-aging；Has effects that moisturizing simultaneously.Lycium barbarum
(LYCIUMBARBARUM) berry extract it have powerful oxidation resistance.The absorbability of its oxyradical is 25,
000 (in contrast blueberry ability 2,500), and it is also rich in calcium, potassium, iron, zinc, selenium, vitamin B and vitamin C.In 1991
One of state studies have shown that the phytochemicals (phytochemicals) in fructus lycii can help prevent O-DNA, restores
Impaired DNA.This shows that it can become the ideal composition in anti-aging product；Purple coneflower (ECHINACEAPURPUREA)
Extract can isolate the triterpene compound of 27 kinds of anti-inflammatory effects, can treat dermatitis, have suppression to the inductivity allergy of skin
Production is used；The resistance of capillary can be enhanced, inhibit capillary permeability and there is anti-inflammatory effect；It can eliminate simultaneously freely
Base has inoxidizability, has and alleviates aging effect；Also there is certain inhibiting effect to melanocyte, so there is certain whitening
The effect of nti-freckle.
The main component of magnolin is Magnolia binodii (MAGNOLIABIONDII) bud/flower extract, wrinkled giant hyssop in the present invention
(AGASTACHERUGOSA) extract, Magnolia binodii (MAGNOLIABIONDII) bud/flower extract can help to reduce subcutaneous
The visibility of capillary reduces black-eyed appearance.Wrinkled giant hyssop (AGASTACHERUGOSA) extract leaves of pulse plants has elimination to free radical
Effect is used as antioxygen anatrophic.
Middle and North America witch hazel (HAMAMELISVIRGINIANA) extract of the present invention makees antioxidant；It being capable of activating cell
Aromatizing enzyme and cathepsin are horizontal to improve cortex local estrogen, enhance skin cell metabolism, there is Antiageing effect,
It can maintain skin elasticity and crease-resistant；With anti-inflammatory, anti-anaphylaxis is releived and convergent effect；There are also good moisture holding capacities simultaneously.
Palpus sunglo (USNEABARBATA) extract is a kind of natural extract from lichens tree in the present invention, wherein leading
Wanting ingredient usnic acid is considered as potent antibiotic and antibacterial agent, can prevent the growth of bacterium and fungi, can be used for deodorization and
It in toothpaste and mouthwash, while being used in cosmetics and personal nursing kind as skin conditioning agent, being cured for wound can be promoted
It closes.
Curdlan has good rheological characteristic in the present invention, almost has all advantages of xanthan gum, thermostabilization
Property be better than xanthan gum.
Hydrolytic collagen is efficient moisture-retention composition, skin-active, inducing tissue regeneration in the present invention, main in human connective tissue
Substance is binded, molecular weight is big, and moisture-retaining capacity more preferably compared with polyalcohols, mainly to support cell, chamfers especially suitable for skin
After matter, skin be in physical therapy made by the most thin stage guarantor.Collagen has good permeability and moisturizing power, is mainly used in
More scar, crease-resistant, pachylosis patient conditioner.Collagen and its hydrolysate compatibility are strong, can be with many functional components
The effect of cooperation is to improve them.
Matrixyl -4 belongs to aging ingredient in the present invention, in the present invention in make skin conditioning agent, antioxidant
It is used with moisturizer.
Palmitoyl oligopeptide makees skin conditioning agent in the present invention and detergent uses.It can promote stromatin
(matrixprotein) the especially synthesis of collagen, while being also possible to increase elastin laminin, hyaluronic acid, glycosaminoglycan
With the generation of fibronectin.
Fermentation of bacillus product is a kind of bacterium that can generate enzyme in the present invention, and produced enzyme can remove skin
Old horn cell.
The main component of ceramide is Caesalpinia spinosaKuntze (CAESALPINIASPINOSA) glue, Cer NP, thorn in the present invention
For mysorethorn (CAESALPINIASPINOSA) glue using Caesalpinia spinosaKuntze as waste, main component is that a kind of galactomannan of neutrality is poly-
Sugar, Cer NP are a kind of lipid matters, and artificial synthesized ingredient, it is close with the structure of matter of keratoderma is constituted, can be very
Skin is penetrated into fastly, is helped the update of skin natural containment, can be promoted the water in the balance and cuticula of nature aquation
In conjunction with forming a kind of reticular structure, lock moisture.
Dipotassium glycyrrhizinate is used as skin conditioning agent in the present invention, predominantly the glycyrrhizin of Radix Glycyrrhizae root and stem
(glycyrrhizic acid) ingredient is suitble to anaphylaxis skin, anti-irritant and oil-control, moves back red and swollen antiphlogistic healing effect.
Bisabolol is extracted from spirea in the present invention, plays the role of anti-inflammatory antibacterial, and the ingredient stability is good and skin
Skin has good compatibility, reduces scytitis, mitigates acne, prevents dark sore from generating, improve the anti-irritant ability of skin,
The skin for having inflammation injury is repaired, spf value is improved in sunscreen product.
Biological polyoses glue -1 is a kind of biological polyoses from Chinese Bohai Offshore in the present invention, because existing in its molecule
A large amount of fucose (L-fucose) is commonly referred to as fucosan " Fucoidan ".It is a kind of novel moisturizing in cosmetic industry
Agent, anti-wrinkle agent, skin repair agent and skin sense regulator.
1,2- hexylene glycol is moisturizer in the present invention, belongs to polyalcohol, has fungistatic effect, only when additive amount is 5%
Left and right Shi Caiyou anti-corrosion effect, but it is not equal to preservative.
Sodium Hyaluronate is also known as sodium hyaluronate sodium in the present invention, belongs to skin conditioner, is a kind of acid mucopolysaccharide, naturally deposits
It is in cornea skin, can absorb itself 1000 times of moisture of weight, reaches by retaining moisture of skin, preventing moisture through epidermis
It is lost, and the barrier reparation when skin is damaged, skin is enabled not feel drying after, increase gloss, it can be with
Improve skin-nourishing metabolism, make skin it is soft, it is smooth, go wrinkle, increase elasticity, prevent aging, be good again while moisturizing
Skin penetration enhancer.It is used cooperatively with other nutritional ingredients, the more preferable effect for promoting nutrient absorption can be played.
Parahydroxyacet-ophenone is a kind of natural plant extracts in the present invention, be naturally present in compositae plant artemisia scoparia stem,
Leaf, in the roots of plants such as Artemisia capillaris, Asclepiadaceae plant, kerr tylophora root.With anti-oxidant and effect of releiving multi-functional cosmetic
Product ingredient；In cosmetics, at the same time as the substitute of traditional preservatives, have the function of anti-corrosion synergy, can promote each
Kind preservative efficacy, there is excellent stability in height pH and temperature range.It can be used for all kinds of formulas, including sun-proof and fragrant
Wave.There are good compatibility in it and various cosmetic compositions and packaging material.
The two of task of the present invention realize by following technical solution:
A kind of above-mentioned a kind of two split the preparation method of yeast freeze-dried powder preparation, the preparation method for splitting yeast freeze-dried powder including two
The preparation method and two for splitting yeast freeze-dried powder (daily) lyase liquid with two split the preparation side of yeast freeze-dried powder (ight) lyase liquid
Method, wherein two split the preparation method of yeast freeze-dried powder the following steps are included:
S1: it the selection of raw material and prepares ratio: choosing deionized water, the mannose by distillation and sterilization processing
Alcohol, oligopeptides -1, oligopeptides -3, Argireline, two split yeast tunning lysis object, glutathione before carrying out mixing match
In vacuum packaging；
S2: yeast tunning lysis object, mannitol, glutathione, acetyl group six are split by quality proportioning weighed two
Peptide -8, oligopeptides -1, oligopeptides -3；
S3: yeast tunning lysis object, glutathione, Argireline, oligopeptides -1, oligopeptides -3, sweet dew are split by two
Mixture, is then placed in mixing plant and is at the uniform velocity stirred by sugar alcohol mixing, is to stir 10min in 600r/min in revolving speed,
Stirring forms mixed solution A；
S4: mixed solution A standing being again placed in mixing plant afterwards for 24 hours and is at the uniform velocity stirred, and is 1200r/ in revolving speed
20min is stirred in min；
S5: mixed solution A is filtered by filter membrane, is removed impurity not soluble in water in mixed solution A and is mixed
Close solution B；
S6: mixed solution B is placed in sterilizing Dewar bottle and is vacuum-packed, storage temperature is controlled at 5 DEG C or less；
S7: mixed solution B being placed in centrifugation apparatus and carries out centrifugally operated, then carries out precooling operation, at this time temperature
Control carries out refrigeration operation, mixed solution B lyophilization after the completion of -15 DEG C, precooling, and temperature is controlled at -5 DEG C；
Deionized water temperature in the S1 is controlled at 50-70 DEG C, and the filter membrane diameter control in the S5 is in 0.1um, institute
Mixed liquor after stating S6 lyophilization need to pass through ultraviolet sterilization；
Wherein two split yeast freeze-dried powder (daily) lyase liquid preparation method the following steps are included:
A, Sodium Hyaluronate, hydrolytic collagen, propylene glycol, glycerol, 1,2- hexylene glycol, guava are weighed by quality proportioning
(PSIDIUMGUAJAVA) berry extract, hamamelis (HAMAMELISVIRGINIANA) extract, palpus sunglo
(USNEABARBATA) extract, ceramide, curdlan class and deionized water dispersion machine are in 7.0-10.0Hz model
It is stirred in enclosing and is dispersed to transparent, obtained material a；
B, by quality proportioning weigh lily magnolia profit dew, magnolin M, reed fragrant plant oil, Matrixyl -4, palmitoyl oligopeptide, to hydroxyl
Benzoylformaldoxime, fermentation of bacillus product are added in the material a, be dispersed with stirring within the scope of 2.0-5.0Hz with dispersion machine to
Uniformly, then described two are made and splits yeast freeze-dried powder (daily) lyase liquid through 150-250 mesh net filtration；
C, apply some make up the semi-automatic gas filling machine of lotion, mixes up each 7.5ml of scale, by the filling 7.5ml of every bottle of ampulla
Lyase liquid；
Wherein two split yeast freeze-dried powder (ight) lyase liquid preparation method the following steps are included:
A, Sodium Hyaluronate, hydrolytic collagen, propylene glycol, glycerol, 1,2- hexylene glycol, guava are weighed by quality proportioning
(PSIDIUMGUAJAVA) berry extract, hamamelis (HAMAMELISVIRGINIANA) extract, palpus sunglo
(USNEABARBATA) extract, ceramide, curdlan class and deionized water dispersion machine are in 7.0-10.0Hz model
It is stirred in enclosing and is dispersed to transparent, obtained material a；
B, lily magnolia profit dew, magnolin M, reed fragrant plant oil, Matrixyl -4, bisabolol, biology sugar are weighed by quality proportioning
Glue -1, dipotassium glycyrrhizinate, palmitoyl oligopeptide, parahydroxyacet-ophenone, fermentation of bacillus product are added in the material a, with point
It dissipates machine to be dispersed with stirring within the scope of 2.0-5.0Hz to uniform, then through 150-250 mesh net filtration, is made described two and splits
Yeast freeze-dried powder (ight) lyase liquid；
C, apply some make up the semi-automatic gas filling machine of lotion, mixes up each 7.5ml of scale, by the filling 7.5ml of every bottle of ampulla
Lyase liquid.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that saying that the specific embodiment of description is used only for explaining the present invention herein, it is not used to
Limit the present invention.
One kind two splits yeast freeze-dried powder preparation, including splits yeast freeze-dried powder by two, two splits yeast freeze-dried powder (daily) lyase
Liquid and two splits the solution that yeast freeze-dried powder (ight) lyase liquid is constituted, wherein two split yeast freeze-dried powder by following quality proportionings
Component be made:
Two split yeast tunning lysis object: 4.5%；
Glutathione: 0.1%；
Argireline: 0.5%；
Oligopeptides -1:0.5%；
Oligopeptides -3:0.25%；
Mannitol: 93.6%；
Two in the present invention split yeast tunning lysis object be through Bifidobacterium culture, inactivation and decompose obtain metabolism produce
Object, cytoplasmic fragment, cell-wall components and polysaccharide composite body.With very strong anti-immunity inhibitory activity and DNA can be promoted to repair,
It is can effectively protect skin, not by UV-induced damage, helps the light aging for preventing epidermis and corium.Two, which split yeast fermentation, produces
The molten spore object of object can generate the small molecule including vitamin group, minerals, amino acid etc. beneficial to skin care, be that one kind is served only for skin care
High-quality yeast essence.Its metabolism that can reinforce cuticula, moreover it is possible to capture free radical, inhibit the peroxidating of lipid, there is beauty
White, anti-aging function.The nutriment being wherein rich in has the function of nourishes rough skin.
Glutathione in the present invention has the antioxidant capacity of wide spectrum, can use in anti-ageing skin care；There is the work of skin whitening
With skin arteries and veins brown stain can be inhibited, and can effectively conditioning skin and moisturizing.
Argireline in the present invention is a kind of biologically active polypeptide, which can both reduce existing face wrinkle
Line, and new wrinkle can be effectively prevent to generate.By inhibiting the release of neurotransmitter acetylcholine (acetylcholine),
The contraction of muscle is reduced, to reach the generation for reducing dynamic line, expression line.
Oligopeptides -1 in the present invention is the synthetic peptide of 3 kinds of amino acid such as glycine, histidine and lysine composition, as skin
Skin conditioner uses.
The small molecule that oligopeptides -3 in the present invention is made of 2-6 amino acid, can be directly effectively by the absorption benefit of cell
With, rapid replenishing collagen such as boosts metabolism to play good opsonic action, stimulates cytothesis, be proliferated,
Newborn collagen, effect is slower, but safety is higher.
Mannitol in the present invention is conducive to the conditioning of skin and anti-ageing to the elimination of peroxynitrite, to skin
Skin allergy also has a degree of inhibiting effect；Mannitol can inhibit the light injury and light aging to skin, and have moisturizing function
Energy.
Two split yeast (daily) lyase liquid is made by the component of following quality proportionings:
Glycerol: 2%；
Propylene glycol: 2%；
Guava (PSIDIUMGUAJAVA) berry extract: 1.2%；
Reed fragrant plant oil: 2%；
Lin Lan profit dew: 1%；
Sodium Hyaluronate: 0.055%；
Magnolin M:0.1%；
Hamamelis (HAMAMELISVIRGINIANA) extract: 0.1%；
Palpus sunglo (USNEABARBATA) extract: 0.1%；
Curdlan class: 0.055%；
Hydrolytic collagen: 0.1%；
Matrixyl -4:0.2%；
Palmitoyl oligopeptide: 0.2%；
Fermentation of bacillus product: 1.25%；
Ceramide: 0.25%；
1,2- hexylene glycol: 0.5%；
Parahydroxyacet-ophenone: 0.5%；
Deionized water: 88.05%；
Glycerol in the present invention is colourless sweet clear and bright thick liquid, odorless, there is warm sweet taste, can be used as solvent, lubricant,
Medicament and sweetener.
Propylene glycol in the present invention can be used as wetting agent with glycerol or sorbierite cooperation.
Guava (PSIDIUMGUAJAVA) berry extract has good lipoid peroxidization resistant, Ke Yiqi in the present invention
To delaying senility function；Inhibition to xanthine oxidase illustrates there is anti-inflammatory and convergent effect, to B-16 melanocyte
Activity shows strong inhibition, is good cosmetics whitening additive.
The main component glycerol polymethacrylates and Gantrez AN-119 of reed fragrant plant oil, the poly- methyl-prop of glycerol in the present invention
Olefin(e) acid ester makees film forming agent in cosmetics and viscosity control agent uses.Glycerol polymethacrylates is water-soluble clear gel,
It is a kind of transparent, multi-functional moisturizing substrate, can increase skin sense and lubricity, improve moisture retention, prepares transparent, colourless production
Product.Gantrez AN-119 is made antistatic agent, adhesive and emulsion stabilizer in cosmetics and is used.
The main component of the pure profit dew of lily magnolia in the present invention has dendrobium candidum (DENDROBIUMCANDIDUM) extract, library
Drag-line aloe (ALOEBARBADENSIS) leaf extract, kuh-seng (SOPHORAANGUSTIFOLIA) root extract, lycium barbarum
(LYCIUMBARBARUM) berry extract, purple coneflower (ECHINACEAPURPUREA) extract.Dendrobium candidum
(DENDROBIUMCANDIDUM) extract can increase the blood flow of capillary, can be used for the promoting blood circulation of the needs such as hair, anti-ageing
Cosmetics；There is elimination to a variety of free radicals, can be used as antioxidant；There is the function of water suction under the low humidity, has and protect
Wet effect.Aloe barbadensis Miller (ALOEBARBADENSIS) leaf extract has various bioactivity, is important in cosmetics
Adding ingredient.From its to fibrin increase facilitation, the inhibition of elastin laminin, the synthesis of collagen and to from
By the scavenging effect of base, illustrate there is good skin-active, anti-aging effect；There is facilitation to cholesterine synthesis, helps to change
The composition of sebum reduces soft and moist degree that is glossy and increasing skin；Also have the function of antibacterial anti-inflammatory and moisturizing simultaneously.Kuh-seng
(SOPHORAANGUSTIFOLIA) root extract is mainly derived from the root of kuh-seng, and effective component is mainly matrine, is a kind of
Traditional herbal medicine has effects that antibacterial anti-inflammatory for treating eczema and dermatitis；There is facilitation to collagen production,
Also there is facilitation to fibroblastic proliferation, can be used as skin anti-aging；Has effects that moisturizing simultaneously.Lycium barbarum
(LYCIUMBARBARUM) berry extract it have powerful oxidation resistance.The absorbability of its oxyradical is 25,
000 (in contrast blueberry ability 2,500), and it is also rich in calcium, potassium, iron, zinc, selenium, vitamin B and vitamin C.In 1991
One of state studies have shown that the phytochemicals (phytochemicals) in fructus lycii can help prevent O-DNA, restores
Impaired DNA.This shows that it can become the ideal composition in anti-aging product；Purple coneflower (ECHINACEAPURPUREA)
Extract can isolate the triterpene compound of 27 kinds of anti-inflammatory effects, can treat dermatitis, have suppression to the inductivity allergy of skin
Production is used；The resistance of capillary can be enhanced, inhibit capillary permeability and there is anti-inflammatory effect；It can eliminate simultaneously freely
Base has inoxidizability, has and alleviates aging effect；Also there is certain inhibiting effect to melanocyte, so there is certain whitening
The effect of nti-freckle.
The main component of magnolin is Magnolia binodii (MAGNOLIABIONDII) bud/flower extract, wrinkled giant hyssop in the present invention
(AGASTACHERUGOSA) extract, Magnolia binodii (MAGNOLIABIONDII) bud/flower extract can help to reduce subcutaneous
The visibility of capillary reduces black-eyed appearance.Wrinkled giant hyssop (AGASTACHERUGOSA) extract leaves of pulse plants has elimination to free radical
Effect is used as antioxygen anatrophic.
Middle and North America witch hazel (HAMAMELISVIRGINIANA) extract of the present invention makees antioxidant；It being capable of activating cell
Aromatizing enzyme and cathepsin are horizontal to improve cortex local estrogen, enhance skin cell metabolism, there is Antiageing effect,
It can maintain skin elasticity and crease-resistant；With anti-inflammatory, anti-anaphylaxis is releived and convergent effect；There are also good moisture holding capacities simultaneously.
Palpus sunglo (USNEABARBATA) extract is a kind of natural extract from lichens tree in the present invention, wherein leading
Wanting ingredient usnic acid is considered as potent antibiotic and antibacterial agent, can prevent the growth of bacterium and fungi, can be used for deodorization and
It in toothpaste and mouthwash, while being used in cosmetics and personal nursing kind as skin conditioning agent, being cured for wound can be promoted
It closes.
Curdlan has good rheological characteristic in the present invention, has all advantages of xanthan gum, thermal stability is excellent
In xanthan gum.
Hydrolytic collagen is efficient moisture-retention composition, skin-active, inducing tissue regeneration in the present invention, main in human connective tissue
Substance is binded, molecular weight is big, and moisture-retaining capacity more preferably compared with polyalcohols, mainly to support cell, chamfers especially suitable for skin
After matter, skin be in physical therapy made by the most thin stage guarantor.Collagen has good permeability and moisturizing power, is mainly used in
More scar, crease-resistant, pachylosis patient conditioner.Collagen and its hydrolysate compatibility are strong, can be with many functional components
The effect of cooperation is to improve them.
Matrixyl -4 belongs to aging ingredient in the present invention, in the present invention in make skin conditioning agent, antioxidant
It is used with moisturizer.
Palmitoyl oligopeptide makees skin conditioning agent in the present invention and detergent uses.It can promote stromatin
(matrixprotein) the especially synthesis of collagen, while being also possible to increase elastin laminin, hyaluronic acid, glycosaminoglycan
With the generation of fibronectin.
Fermentation of bacillus product is a kind of bacterium that can generate enzyme in the present invention, and produced enzyme can remove skin
Old horn cell.
The main component of ceramide is Caesalpinia spinosaKuntze (CAESALPINIASPINOSA) glue, Cer NP, thorn in the present invention
For mysorethorn (CAESALPINIASPINOSA) glue using Caesalpinia spinosaKuntze as waste, main component is that a kind of galactomannan of neutrality is poly-
Sugar, Cer NP are a kind of lipid matters, and artificial synthesized ingredient, it is close with the structure of matter of keratoderma is constituted, can be very
Skin is penetrated into fastly, is helped the update of skin natural containment, can be promoted the water in the balance and cuticula of nature aquation
In conjunction with forming a kind of reticular structure, lock moisture.
1,2- hexylene glycol is moisturizer in the present invention, belongs to polyalcohol, has fungistatic effect, only when additive amount is 5%
Left and right Shi Caiyou anti-corrosion effect, but it is not equal to preservative.
Sodium Hyaluronate is also known as sodium hyaluronate sodium in the present invention, belongs to skin conditioner, is a kind of acid mucopolysaccharide, naturally deposits
It is in cornea skin, can absorb itself 1000 times of moisture of weight, reaches by retaining moisture of skin, preventing moisture through epidermis
It is lost, and the barrier reparation when skin is damaged, skin is enabled not feel drying after, increase gloss, it can be with
Improve skin-nourishing metabolism, make skin it is soft, it is smooth, go wrinkle, increase elasticity, prevent aging, be good again while moisturizing
Skin penetration enhancer.It is used cooperatively with other nutritional ingredients, the more preferable effect for promoting nutrient absorption can be played.
Parahydroxyacet-ophenone is a kind of natural plant extracts in the present invention, be naturally present in compositae plant artemisia scoparia stem,
Leaf, in the roots of plants such as Artemisia capillaris, Asclepiadaceae plant, kerr tylophora root.With anti-oxidant and effect of releiving multi-functional cosmetic
Product ingredient；In cosmetics, at the same time as the substitute of traditional preservatives, have the function of anti-corrosion synergy, can promote each
Kind preservative efficacy, has excellent stability in height pH and temperature range, can be used for all kinds of formulas, including sun-proof and fragrant
There are good compatibility in wave, it and various cosmetic compositions and packaging material.
Two split yeast (ight) lyase liquid is made by the component of following quality proportionings:
Glycerol: 2%；
Propylene glycol: 2%；
Guava (PSIDIUMGUAJAVA) berry extract: 1.2%；
Reed fragrant plant oil: 2%；
Starfish branch tube algae (CLADOSIPHONNOVAE-CALEDONIAE) extract: 1%；
Lin Lan profit dew: 1%；
Sodium Hyaluronate: 0.05%；
Magnolin M:0.15%；
Hamamelis (HAMAMELISVIRGINIANA) extract: 0.1%；
Palpus sunglo (USNEABARBATA) extract: 0.1%；
Curdlan class: 0.05%；
Hydrolytic collagen: 0.1%；
Matrixyl -4:0.02%；
Palmitoyl oligopeptide: 0.02%；
Fermentation of bacillus product: 1.5%；
Ceramide: 0.25%；
Dipotassium glycyrrhizinate: 0.1%；
Bisabolol: 0.05%；
Biological carbohydrate gum -1:0.55%；
1,2- hexylene glycol: 0.55%；
Parahydroxyacet-ophenone: 0.55%；
Deionized water: 86.5%；
Glycerol in the present invention is colourless sweet clear and bright thick liquid, odorless, there is warm sweet taste, can be used as solvent, lubricant,
Medicament and sweetener.
Propylene glycol in the present invention can be used as wetting agent with glycerol or sorbierite cooperation.
Guava (PSIDIUMGUAJAVA) berry extract has good lipoid peroxidization resistant, Ke Yiqi in the present invention
To delaying senility function；Inhibition to xanthine oxidase illustrates there is anti-inflammatory and convergent effect, to B-16 melanocyte
Activity shows strong inhibition, is good cosmetics whitening additive.
The main component glycerol polymethacrylates and Gantrez AN-119 of reed fragrant plant oil, the poly- methyl-prop of glycerol in the present invention
Olefin(e) acid ester makees film forming agent in cosmetics and viscosity control agent uses.Glycerol polymethacrylates is water-soluble clear gel,
It is a kind of transparent, multi-functional moisturizing substrate, can increase skin sense and lubricity, improve moisture retention, prepares transparent, colourless production
Product.Gantrez AN-119 is made antistatic agent, adhesive and emulsion stabilizer in cosmetics and is used.
Starfish branch tube algae extract has inhibition to prolyl endopeptidase in the present invention, and to adjusting, angiotensins, nerve are tight
Zhang Suyou benefit, illustrates have the function of releiving, and in conjunction with its inoxidizability, can be used for skin maintenance；Hyaluronidase has inhibition
Effect, can be effectively suppressed the decomposition of hyaluronic acid, thus have skin moisture-keeping effect
The main component of the pure profit dew of lily magnolia in the present invention has dendrobium candidum (DENDROBIUMCANDIDUM) extract, library
Drag-line aloe (ALOEBARBADENSIS) leaf extract, kuh-seng (SOPHORAANGUSTIFOLIA) root extract, lycium barbarum
(LYCIUMBARBARUM) berry extract, purple coneflower (ECHINACEAPURPUREA) extract.Dendrobium candidum
(DENDROBIUMCANDIDUM) extract can increase the blood flow of capillary, can be used for the promoting blood circulation of the needs such as hair, anti-ageing
Cosmetics；There is elimination to a variety of free radicals, can be used as antioxidant；There is the function of water suction under the low humidity, has and protect
Wet effect.Aloe barbadensis Miller (ALOEBARBADENSIS) leaf extract has various bioactivity, is important in cosmetics
Adding ingredient.From its to fibrin increase facilitation, the inhibition of elastin laminin, the synthesis of collagen and to from
By the scavenging effect of base, illustrate there is good skin-active, anti-aging effect；There is facilitation to cholesterine synthesis, helps to change
The composition of sebum reduces soft and moist degree that is glossy and increasing skin；Also have the function of antibacterial anti-inflammatory and moisturizing simultaneously.Kuh-seng
(SOPHORAANGUSTIFOLIA) root extract is mainly derived from the root of kuh-seng, and effective component is mainly matrine, is a kind of
Traditional herbal medicine.For treating eczema and dermatitis, has effects that antibacterial anti-inflammatory；There is facilitation to collagen production,
Also there is facilitation to fibroblastic proliferation, can be used as skin anti-aging；Has effects that moisturizing simultaneously.Lycium barbarum
(LYCIUMBARBARUM) berry extract it have powerful oxidation resistance.The absorbability of its oxyradical is 25,
000 (in contrast blueberry ability 2,500), and it is also rich in calcium, potassium, iron, zinc, selenium, vitamin B and vitamin C.In 1991
One of state studies have shown that the phytochemicals (phytochemicals) in fructus lycii can help prevent O-DNA, restores
Impaired DNA.This shows that it can become the ideal composition in anti-aging product；Purple coneflower (ECHINACEAPURPUREA)
Extract can isolate the triterpene compound of 27 kinds of anti-inflammatory effects, can treat dermatitis, have suppression to the inductivity allergy of skin
Production is used；The resistance of capillary can be enhanced, inhibit capillary permeability and there is anti-inflammatory effect；It can eliminate simultaneously freely
Base has inoxidizability, has and alleviates aging effect；Also there is certain inhibiting effect to melanocyte, so there is certain whitening
The effect of nti-freckle.
The main component of magnolin is Magnolia binodii (MAGNOLIABIONDII) bud/flower extract, wrinkled giant hyssop in the present invention
(AGASTACHERUGOSA) extract, Magnolia binodii (MAGNOLIABIONDII) bud/flower extract can help to reduce subcutaneous
The visibility of capillary reduces black-eyed appearance.Wrinkled giant hyssop (AGASTACHERUGOSA) extract leaves of pulse plants has elimination to free radical
Effect is used as antioxygen anatrophic.
Middle and North America witch hazel (HAMAMELISVIRGINIANA) extract of the present invention makees antioxidant；It being capable of activating cell
Aromatizing enzyme and cathepsin are horizontal to improve cortex local estrogen, enhance skin cell metabolism, there is Antiageing effect,
It can maintain skin elasticity and crease-resistant；With anti-inflammatory, anti-anaphylaxis is releived and convergent effect；There are also good moisture holding capacities simultaneously.
Palpus sunglo (USNEABARBATA) extract is a kind of natural extract from lichens tree in the present invention, wherein leading
Wanting ingredient usnic acid is considered as potent antibiotic and antibacterial agent, can prevent the growth of bacterium and fungi, can be used for deodorization and
It in toothpaste and mouthwash, while being used in cosmetics and personal nursing kind as skin conditioning agent, being cured for wound can be promoted
It closes.
Curdlan has good rheological characteristic in the present invention, almost has all advantages of xanthan gum, thermostabilization
Property be better than xanthan gum.
Hydrolytic collagen is efficient moisture-retention composition, skin-active, inducing tissue regeneration in the present invention, main in human connective tissue
Substance is binded, molecular weight is big, and moisture-retaining capacity more preferably compared with polyalcohols, mainly to support cell, chamfers especially suitable for skin
After matter, skin be in physical therapy made by the most thin stage guarantor.Collagen has good permeability and moisturizing power, is mainly used in
More scar, crease-resistant, pachylosis patient conditioner.Collagen and its hydrolysate compatibility are strong, can be with many functional components
The effect of cooperation is to improve them.
Matrixyl -4 belongs to aging ingredient in the present invention, in the present invention in make skin conditioning agent, antioxidant
It is used with moisturizer.
Palmitoyl oligopeptide makees skin conditioning agent in the present invention and detergent uses.It can promote stromatin
(matrixprotein) the especially synthesis of collagen, while being also possible to increase elastin laminin, hyaluronic acid, glycosaminoglycan
With the generation of fibronectin.
Fermentation of bacillus product is a kind of bacterium that can generate enzyme in the present invention, and produced enzyme can remove skin
Old horn cell.
The main component of ceramide is Caesalpinia spinosaKuntze (CAESALPINIASPINOSA) glue, Cer NP, thorn in the present invention
For mysorethorn (CAESALPINIASPINOSA) glue using Caesalpinia spinosaKuntze as waste, main component is that a kind of galactomannan of neutrality is poly-
Sugar, Cer NP are a kind of lipid matters, and artificial synthesized ingredient, it is close with the structure of matter of keratoderma is constituted, can be very
Skin is penetrated into fastly, is helped the update of skin natural containment, can be promoted the water in the balance and cuticula of nature aquation
In conjunction with forming a kind of reticular structure, lock moisture.
Dipotassium glycyrrhizinate is used as skin conditioning agent in the present invention, predominantly the glycyrrhizin of Radix Glycyrrhizae root and stem
(glycyrrhizic acid) ingredient is suitble to anaphylaxis skin, anti-irritant and oil-control, moves back red and swollen antiphlogistic healing effect.
Bisabolol is extracted from spirea in the present invention, plays the role of anti-inflammatory antibacterial, and the ingredient stability is good and skin
Skin has good compatibility, reduces scytitis, mitigates acne, prevents dark sore from generating, improve the anti-irritant ability of skin,
The skin for having inflammation injury is repaired, spf value is improved in sunscreen product.
Biological polyoses glue -1 is a kind of biological polyoses from Chinese Bohai Offshore in the present invention, because existing in its molecule
A large amount of fucose (L-fucose) is commonly referred to as fucosan " Fucoidan ".It is a kind of novel moisturizing in cosmetic industry
Agent, anti-wrinkle agent, skin repair agent and skin sense regulator.
1,2- hexylene glycol is moisturizer in the present invention, belongs to polyalcohol, has fungistatic effect, only when additive amount is 5%
Left and right Shi Caiyou anti-corrosion effect, but it is not equal to preservative.
Sodium Hyaluronate is also known as sodium hyaluronate sodium in the present invention, belongs to skin conditioner, is a kind of acid mucopolysaccharide, naturally deposits
It is in cornea skin, can absorb itself 1000 times of moisture of weight, reaches by retaining moisture of skin, preventing moisture through epidermis
It is lost, and the barrier reparation when skin is damaged, skin is enabled not feel drying after, increase gloss, it can be with
Improve skin-nourishing metabolism, make skin it is soft, it is smooth, go wrinkle, increase elasticity, prevent aging, be good again while moisturizing
Skin penetration enhancer.It is used cooperatively with other nutritional ingredients, the more preferable effect for promoting nutrient absorption can be played.
Parahydroxyacet-ophenone is a kind of natural plant extracts in the present invention, be naturally present in compositae plant artemisia scoparia stem,
Leaf, in the roots of plants such as Artemisia capillaris, Asclepiadaceae plant, kerr tylophora root.With anti-oxidant and effect of releiving multi-functional cosmetic
Product ingredient；In cosmetics, at the same time as the substitute of traditional preservatives, have the function of anti-corrosion synergy, can promote each
Kind preservative efficacy, there is excellent stability in height pH and temperature range.It can be used for all kinds of formulas, including sun-proof and fragrant
Wave.There are good compatibility in it and various cosmetic compositions and packaging material.
The two of task of the present invention realize by following technical solution:
A kind of above-mentioned a kind of two split the preparation method of yeast freeze-dried powder preparation, the preparation method for splitting yeast freeze-dried powder including two
The preparation method and two for splitting yeast freeze-dried powder (daily) lyase liquid with two split the preparation side of yeast freeze-dried powder (ight) lyase liquid
Method, wherein two split the preparation method of yeast freeze-dried powder the following steps are included:
S1: it the selection of raw material and prepares ratio: choosing deionized water, the mannose by distillation and sterilization processing
Alcohol, oligopeptides -1, oligopeptides -3, Argireline, two split yeast tunning lysis object, glutathione before carrying out mixing match
In vacuum packaging；
S2: two are weighed by quality proportioning and splits yeast tunning lysis object, mannitol, glutathione, acetyl group hexapeptide-
8, oligopeptides -1, oligopeptides -3；
S3: yeast tunning lysis object, glutathione, Argireline, oligopeptides -1, oligopeptides -3, sweet dew are split by two
Mixture, is then placed in mixing plant and is at the uniform velocity stirred by sugar alcohol mixing, is to stir 10min in 600r/min in revolving speed,
Stirring forms mixed solution A；
S4: mixed solution A standing being again placed in mixing plant afterwards for 24 hours and is at the uniform velocity stirred, and is 1200r/ in revolving speed
20min is stirred in min；
S5: mixed solution A is filtered by filter membrane, is removed impurity not soluble in water in mixed solution A and is mixed
Close solution B；
S6: mixed solution B is placed in sterilizing Dewar bottle and is vacuum-packed, storage temperature is controlled at 5 DEG C or less；
S7: mixed solution B being placed in centrifugation apparatus and carries out centrifugally operated, then carries out precooling operation, at this time temperature
Control carries out refrigeration operation, mixed solution B lyophilization after the completion of -15 DEG C, precooling, and temperature is controlled at -5 DEG C；
Deionized water temperature in the S1 is controlled at 50-70 DEG C, and the filter membrane diameter control in the S5 is in 0.1um, institute
Mixed liquor after stating S6 lyophilization need to pass through ultraviolet sterilization；
Wherein two split yeast freeze-dried powder (daily) lyase liquid preparation method the following steps are included:
A, Sodium Hyaluronate, hydrolytic collagen, propylene glycol, glycerol, 1,2- hexylene glycol, guava are weighed by quality proportioning
(PSIDIUMGUAJAVA) berry extract, hamamelis (HAMAMELISVIRGINIANA) extract, palpus sunglo
(USNEABARBATA) extract, ceramide, curdlan class and deionized water dispersion machine are in 7.0-10.0Hz model
It is stirred in enclosing and is dispersed to transparent, obtained material a；
B, by quality proportioning weigh lily magnolia profit dew, magnolin M, reed fragrant plant oil, Matrixyl -4, palmitoyl oligopeptide, to hydroxyl
Benzoylformaldoxime, fermentation of bacillus product are added in the material a, be dispersed with stirring within the scope of 2.0-5.0Hz with dispersion machine to
Uniformly, then described two are made and splits yeast freeze-dried powder (daily) lyase liquid through 150-250 mesh net filtration；
C, apply some make up the semi-automatic gas filling machine of lotion, mixes up each 7.5ml of scale, by the filling 7.5ml of every bottle of ampulla
Lyase liquid；
Wherein two split yeast freeze-dried powder (ight) lyase liquid preparation method the following steps are included:
A, Sodium Hyaluronate, hydrolytic collagen, propylene glycol, glycerol, 1,2- hexylene glycol, guava are weighed by quality proportioning
(PSIDIUMGUAJAVA) berry extract, hamamelis (HAMAMELISVIRGINIANA) extract, palpus sunglo
(USNEABARBATA) extract, ceramide, curdlan class and deionized water dispersion machine are in 7.0-10.0Hz model
It is stirred in enclosing and is dispersed to transparent, obtained material a；
B, lily magnolia profit dew, magnolin M, reed fragrant plant oil, Matrixyl -4, bisabolol, biology sugar are weighed by quality proportioning
Glue -1, dipotassium glycyrrhizinate, palmitoyl oligopeptide, parahydroxyacet-ophenone, fermentation of bacillus product are added in the material a, with point
It dissipates machine to be dispersed with stirring within the scope of 2.0-5.0Hz to uniform, then through 150-250 mesh net filtration, is made described two and splits
Yeast freeze-dried powder (ight) lyase liquid；
C, apply some make up the semi-automatic gas filling machine of lotion, mixes up each 7.5ml of scale, by the filling 7.5ml of every bottle of ampulla
Lyase liquid.
Freeze-dried powder of the invention can promote aquaporin AQP3 in keratinocyte to express, and fluid infusion is promoted the production of body fluid, immediately
It smooths dry caused microgroove and plays bits, persistently feeding profit skin.
Freeze-dried powder preparation of the invention play the role of whitening it is anti-ageing, nourish skin, this is because two split yeast tunning
Lysis object has very strong anti-immunity inhibitory activity and DNA can be promoted to repair, and skin is can effectively protect, not by UV-induced
Damage helps the light aging for preventing epidermis and corium.Two split the molten spore object of yeast tunning, can generate including vitamin group, mine
Substance, amino acid etc. are a kind of high-quality yeast essence for being served only for skin care beneficial to the small molecule of skin care.It can reinforce cuticula
Metabolism, moreover it is possible to capture free radical, inhibit the peroxidating of lipid, have the function of whitening and anti-aging.The nutrients being wherein rich in
Matter has the function of nourishes rough skin.
Freeze-dried powder preparation of the invention plays the role of whitening spot-removing, reparation of releiving, this is because guava (PSIDIUM
GUAJAVA) berry extract, hamamelis (HAMAMELIS VIRGINIANA) extract, starfish branch tube algae
(CLADOSIPHON NOVAE-CALEDONIAE) extract, palpus sunglo (USNEA BARBATA) extract, magnolin M etc. are more
The synergistic effect of Plant Extracts.
Above description is only embodiments herein and the explanation to institute's application technology principle.Those skilled in the art answer
Work as understanding, invention scope involved in the application, however it is not limited to technical solution made of the specific combination of above-mentioned technical characteristic,
It should also cover in the case where not departing from the inventive concept simultaneously, carry out any group by above-mentioned technical characteristic or its equivalent feature
The other technical solutions closed and formed.Such as features described above and (but being not limited to) disclosed herein have the skill of similar functions
Art feature is replaced mutually and the technical solution that is formed.
Claims (2)
1. one kind two splits yeast freeze-dried powder preparation, which is characterized in that including being split by two, yeast freeze-dried powder, two to split yeast (daily) molten
Enzyme solution and two splits the solution that yeast (ight) lyase liquid is constituted, wherein two split yeast freeze-dried powder by the group of following quality proportionings
Part is made:
Two split yeast tunning lysis object: 2.5-7.5%；
Glutathione: 0.05-0.15%；
Argireline: 0.25-0.75%；
Oligopeptides -1:0.25-0.75%；
Oligopeptides -3:0.15-0.45%；
Mannitol: 90.4%-96.8%；
Two split yeast (daily) lyase liquid is made by the component of following quality proportionings:
Glycerol: 1-3%；
Propylene glycol: 1-3%；
Guava (PSIDIUMGUAJAVA) berry extract: 0.6-1.8%；
Reed fragrant plant oil: 1-3%；
Lin Lan profit dew: 0.5-1.5%；
Sodium Hyaluronate: 0.025-0.075%；
Magnolin M:0.075-0.225%；
Hamamelis (HAMAMELISVIRGINIANA) extract: 0.05-0.15%；
Palpus sunglo (USNEABARBATA) extract: 0.05-0.15%；
Curdlan class: 0.025-0.075%；
Hydrolytic collagen: 0.05-0.15%；
Matrixyl -4:0.01-0.03%；
Palmitoyl oligopeptide: 0.01-0.03%；
Fermentation of bacillus product: 0.75-2.25%；
Ceramide: 0.15-0.45%；
1,2- hexylene glycol: 0.25-0.75%；
Parahydroxyacet-ophenone: 0.25-0.75%；
Deionized water: 82.615-94.205%；
Two split yeast (ight) lyase liquid is made by the component of following quality proportionings:
Glycerol: 1-3%；
Propylene glycol: 1-3%；
Guava (PSIDIUMGUAJAVA) berry extract: 0.6-1.8%；
Reed fragrant plant oil: 1-3%；
Starfish branch tube algae (CLADOSIPHONNOVAE-CALEDONIAE) extract: 0.5-1.5%；
Lin Lan profit dew: 0.5-1.5%；
Sodium Hyaluronate: 0.025-0.075%；
Magnolin M:0.075-0.225%；
Hamamelis (HAMAMELISVIRGINIANA) extract: 0.05-0.15%；
Palpus sunglo (USNEABARBATA) extract: 0.05-0.15%；
Curdlan class: 0.025-0.075%；
Hydrolytic collagen: 0.05-0.15%；
Matrixyl -4:0.01-0.03%；
Palmitoyl oligopeptide: 0.01-0.03%；
Fermentation of bacillus product: 0.75-2.25%；
Ceramide: 0.15-0.45%；
Dipotassium glycyrrhizinate: 0.05-0.15%；
Bisabolol: 0.025-0.075%；
Biological carbohydrate gum -1:0.25-0.75%；
1,2- hexylene glycol: 0.25-0.75%；
Parahydroxyacet-ophenone: 0.25-0.75%；
Deionized water: 80.14-93.38%.
2. a kind of preparation method for splitting yeast freeze-dried powder preparation based on one kind two described in claim 1, which is characterized in that including two
Split the preparation method of yeast freeze-dried powder, two preparation methods and two for splitting yeast freeze-dried powder (daily) lyase liquid split yeast freeze-dried powder
The preparation method of (ight) lyase liquid, wherein two split the preparation method of yeast freeze-dried powder the following steps are included:
S1: it the selection of raw material and prepares ratio: choosing by distillation and the deionized water of sterilization processing, mannitol, widow
Peptide -1, oligopeptides -3, Argireline, two split yeast tunning lysis object, glutathione is in front of carrying out mixing match
Vacuum packaging；
S2: by quality proportioning weighed two split yeast tunning lysis object, mannitol, glutathione, Argireline,
Oligopeptides -1, oligopeptides -3；
S3: yeast tunning lysis object, glutathione, Argireline, oligopeptides -1, oligopeptides -3, mannitol are split by two
Mixture, is then placed in mixing plant and is at the uniform velocity stirred by mixing, is to stir 10min in 600r/min in revolving speed, stirs
Form mixed solution A；
S4: mixed solution A standing being again placed in mixing plant afterwards for 24 hours and is at the uniform velocity stirred, and is in 1200r/min in revolving speed
Stir 20min；
S5: mixed solution A is filtered by filter membrane, and impurity not soluble in water obtains mixing molten in removing mixed solution A
Liquid B；
S6: mixed solution B is placed in sterilizing Dewar bottle and is vacuum-packed, storage temperature is controlled at 5 DEG C or less；
S7: mixed solution B being placed in centrifugation apparatus and carries out centrifugally operated, then carries out precooling operation, and temperature controls at this time
Refrigeration operation, mixed solution B lyophilization are carried out after the completion of -15 DEG C, precooling, temperature is controlled at -5 DEG C；
Deionized water temperature in the S1 is controlled at 50-70 DEG C, and the filter membrane diameter control in the S5 is in 0.1um, the S6
Mixed liquor after lyophilization need to pass through ultraviolet sterilization；
Wherein two split yeast freeze-dried powder (daily) lyase liquid preparation method the following steps are included:
A, Sodium Hyaluronate, hydrolytic collagen, propylene glycol, glycerol, 1,2- hexylene glycol, guava are weighed by quality proportioning
(PSIDIUMGUAJAVA) berry extract, hamamelis (HAMAMELISVIRGINIANA) extract, palpus sunglo
(USNEABARBATA) extract, ceramide, curdlan class and deionized water dispersion machine are in 7.0-10.0Hz model
It is stirred in enclosing and is dispersed to transparent, obtained material a；
B, lily magnolia profit dew, magnolin M, reed fragrant plant oil, Matrixyl -4, palmitoyl oligopeptide, para hydroxybenzene are weighed by quality proportioning
Ethyl ketone, fermentation of bacillus product are added in the material a, are dispersed with stirring within the scope of 2.0-5.0Hz with dispersion machine to uniform,
Then through 150-250 mesh net filtration, described two is made and splits yeast freeze-dried powder (daily) lyase liquid；
C, apply some make up the semi-automatic gas filling machine of lotion, mixes up each 7.5ml of scale, by the filling 7.5ml lyase of every bottle of ampulla
Liquid；
Wherein two split yeast freeze-dried powder (ight) lyase liquid preparation method the following steps are included:
A, Sodium Hyaluronate, hydrolytic collagen, propylene glycol, glycerol, 1,2- hexylene glycol, guava are weighed by quality proportioning
(PSIDIUMGUAJAVA) berry extract, hamamelis (HAMAMELISVIRGINIANA) extract, palpus sunglo
(USNEABARBATA) extract, ceramide, curdlan class and deionized water dispersion machine are in 7.0-10.0Hz model
It is stirred in enclosing and is dispersed to transparent, obtained material a；
B, by quality proportioning weigh lily magnolia profit dew, magnolin M, reed fragrant plant oil, Matrixyl -4, bisabolol, biology carbohydrate gum -1,
Dipotassium glycyrrhizinate, palmitoyl oligopeptide, parahydroxyacet-ophenone, fermentation of bacillus product are added in the material a, are existed with dispersion machine
It is dispersed with stirring within the scope of 2.0-5.0Hz to uniform, then through 150-250 mesh net filtration, is made described two and splits yeast jelly
Dry powder (ight) lyase liquid；
C, apply some make up the semi-automatic gas filling machine of lotion, mixes up each 7.5ml of scale, by the filling 7.5ml lyase of every bottle of ampulla
Liquid.
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| CN111388394A (en) * | 2020-04-22 | 2020-07-10 | 广州栋方生物科技股份有限公司 | Biphase freeze-dried powder solvent and preparation method and application thereof |
| CN115040448A (en) * | 2022-06-29 | 2022-09-13 | 大疆(天津)国际贸易有限公司 | Skin care product with enhanced anti-aging effect and preparation method thereof |
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| CN115040448A (en) * | 2022-06-29 | 2022-09-13 | 大疆(天津)国际贸易有限公司 | Skin care product with enhanced anti-aging effect and preparation method thereof |
| CN115414294A (en) * | 2022-09-06 | 2022-12-02 | 南京天其美生物技术有限公司 | Herbal soothing repair essence and preparation method thereof |
| CN115670992A (en) * | 2022-09-06 | 2023-02-03 | 南京天其美生物技术有限公司 | Herbal peritoneal membrane for gestation repair and preparation method thereof |
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Application publication date: 20190712 |