CN110638719A - Skin care composition, skin care cream and preparation method thereof - Google Patents
Skin care composition, skin care cream and preparation method thereof Download PDFInfo
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- CN110638719A CN110638719A CN201911022890.5A CN201911022890A CN110638719A CN 110638719 A CN110638719 A CN 110638719A CN 201911022890 A CN201911022890 A CN 201911022890A CN 110638719 A CN110638719 A CN 110638719A
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- 239000000203 mixture Substances 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000000284 extract Substances 0.000 claims abstract description 39
- 239000000419 plant extract Substances 0.000 claims abstract description 37
- WSGCRSMLXFHGRM-DEVHWETNSA-N (2s)-2-[[(2s)-6-amino-2-[[(2s,3r)-2-[[(2s,3r)-2-[[(2s)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-3-hydroxypropanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O WSGCRSMLXFHGRM-DEVHWETNSA-N 0.000 claims abstract description 23
- AJLNZWYOJAWBCR-OOPVGHQCSA-N (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-car Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=C)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O AJLNZWYOJAWBCR-OOPVGHQCSA-N 0.000 claims abstract description 17
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- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims description 26
- 238000002156 mixing Methods 0.000 claims description 24
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- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 16
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 16
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 13
- PKPOVTYZGGYDIJ-UHFFFAOYSA-N dioctyl carbonate Chemical compound CCCCCCCCOC(=O)OCCCCCCCC PKPOVTYZGGYDIJ-UHFFFAOYSA-N 0.000 claims description 13
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- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 13
- -1 polydimethylsiloxane Polymers 0.000 claims description 13
- NEOZOXKVMDBOSG-UHFFFAOYSA-N propan-2-yl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C NEOZOXKVMDBOSG-UHFFFAOYSA-N 0.000 claims description 13
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- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical group CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 9
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- 229910019142 PO4 Inorganic materials 0.000 claims description 8
- 229960000541 cetyl alcohol Drugs 0.000 claims description 8
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 8
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims description 8
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 8
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- 239000010452 phosphate Substances 0.000 claims description 8
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 8
- 229940075507 glyceryl monostearate Drugs 0.000 claims description 7
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 7
- 239000013538 functional additive Substances 0.000 claims description 6
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- 239000000043 antiallergic agent Substances 0.000 claims description 5
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- 239000002884 skin cream Substances 0.000 claims description 4
- 240000007185 Albizia julibrissin Species 0.000 claims description 3
- 235000011468 Albizia julibrissin Nutrition 0.000 claims description 3
- 244000144927 Aloe barbadensis Species 0.000 claims description 3
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- 239000009636 Huang Qi Substances 0.000 claims description 3
- 241001180876 Saposhnikovia Species 0.000 claims description 3
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- NWGKJDSIEKMTRX-BFWOXRRGSA-N [(2r)-2-[(3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)C1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-BFWOXRRGSA-N 0.000 description 6
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- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
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- 102000008186 Collagen Human genes 0.000 description 1
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- 210000004207 dermis Anatomy 0.000 description 1
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- 230000003467 diminishing effect Effects 0.000 description 1
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- 238000002474 experimental method Methods 0.000 description 1
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- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
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- 229940078015 myristoyl pentapeptide-4 Drugs 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
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- 210000001626 skin fibroblast Anatomy 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 229910052979 sodium sulfide Inorganic materials 0.000 description 1
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
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- 238000003786 synthesis reaction Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to a skin care composition, a skin care cream and a preparation method thereof. The skin care composition comprises the following components in percentage by mass (2-8): (0.5-5): (1-10) acetyl hexapeptide-8, palmitoyl pentapeptide-4, and plant extracts comprising stem extract of dendrobium nobile lindl, leaf extract of aloe barbadensis and root extract of sophora flavescens ait. The invention matches plant extracts containing dendrobium stem extract, aloe barbadensis leaf extract and sophora flavescens root extract with acetyl hexapeptide-8 and palmitoyl pentapeptide-4 in a proper proportion to form the skin care composition. The applicant finds that the cream prepared from the skin care composition can effectively moisturize and improve the skin fineness and experience feeling, and the key point is that the moisturizing time can be obviously prolonged, and the anti-wrinkle effect is very obvious.
Description
Technical Field
The invention relates to the technical field of daily chemical industry, in particular to a skin care composition, a skin care cream and a preparation method thereof.
Background
Daily skin care is indispensable, people have high requirements on facial skin in life, and people want the facial skin to be tender, soft, smooth, elastic and fair skin, which is also the requirement of people on facial beautification. However, people lose moisture and make the facial skin rough and unsmooth due to ultraviolet irradiation of the facial skin by sunlight, contamination and oxidation of corrosive substances in the air, and factors in their bodies. In addition, with the age, wrinkles become more prominent, and the demand for anti-wrinkle of skin care products is increasing. Therefore, various skin care products come into play, for example, skin care products containing small molecular polypeptides disclosed in the prior art comprise four small molecular polypeptides of palmitoyl pentapeptide-4, acetyl hexapeptide-8, acetyl tetrapeptide-5 and myristoyl pentapeptide-4, and plant extracts, moisturizers and other auxiliary agents are reasonably matched. However, in the actual use process of these products, although they have a certain moisture retention effect, the improvement of the fineness is not good enough.
Disclosure of Invention
Based on this, it is a primary object of the present invention to provide a skin care composition. The cream prepared from the skin care composition has a good moisturizing effect, and can also obviously improve the skin fineness.
The invention mainly aims to provide a skin care composition, which comprises the following components in percentage by mass (2-8): (0.5-5): (1-10) acetyl hexapeptide-8, palmitoyl pentapeptide-4, and plant extracts comprising stem extract of dendrobium nobile lindl, leaf extract of aloe barbadensis and root extract of sophora flavescens ait.
In one embodiment, the mass ratio of the acetyl hexapeptide-8, the palmitoyl pentapeptide-4 and the plant extract is (2-6): (1-5): (3-8).
In one embodiment, the mass ratio of the acetyl hexapeptide-8, the palmitoyl pentapeptide-4 and the plant extract is (2.5-4): (4-5): (5.5-7).
In one embodiment, the mass ratio of the dendrobium stem extract to the aloe barbadensis leaf extract to the sophora flavescens root extract is (1-4): (6-10): (5-7).
The invention also aims to provide application of the skin care composition in preparing skin care products.
In one embodiment, the skin care product is a skin care cream.
The invention further aims to provide a skin-care cream, which comprises water and the following components in percentage by mass:
in one embodiment, the other functional auxiliary agents comprise the following components in percentage by mass:
in one embodiment, the antioxidant is tocopheryl acetate; or/and the chelating agent is disodium ETDA; or/and the pH regulator is potassium hydroxide; or/and the preservative is
K350; and/or, the anti-allergy agent is at least one of astragalus membranaceus root extract, divaricate saposhnikovia root extract, calendula officinalis extract, albizia julibrissin extract and gastrodia elata root extract.
In one embodiment, the emulsifier is selected from at least one of cetyl alcohol, C20-22 alcohol phosphate, and glyceryl monostearate; or/and the emollient is selected from at least one of behenyl alcohol, caprylic/capric triglyceride, isopropyl isostearate, dioctyl carbonate and polydimethylsiloxane; or/and the skin feel regulator is polymethyl methacrylate; the humectant is selected from at least one of glycerin and butanediol; or/and the thickening agent is carbomer.
In one embodiment, the emulsifier is prepared by mixing the following components in a mass ratio of (1-5): (0.2-3): (0.3-3) a combination of cetyl alcohol, C20-22 alcohol phosphate and glyceryl monostearate; the emollient is (0.5-4): (1-5): (2-7): (0.1-3): (1-6) a combination of behenyl alcohol, caprylic/capric triglyceride, isopropyl isostearate, dioctyl carbonate and polydimethylsiloxane.
The invention also aims to provide a preparation method of the skin care cream, which comprises the following steps:
(1) mixing emulsifier, emollient and skin feeling regulator to prepare phase A; mixing the moisturizing agent, the thickening agent, part of other functional additives and water to prepare a phase B;
(2) adding phase B into phase A, and mixing;
(3) mixing the other part of other functional additives with water to prepare a phase C, adding the phase C into the product obtained in the step (2), and mixing;
(4) mixing the rest of other functional adjuvants and the skin care composition to obtain phase D, adding the phase D into the product obtained in step (3), and mixing.
Compared with the prior art, the invention has the following advantages and beneficial effects:
the invention matches plant extracts containing dendrobium stem extract, aloe barbadensis leaf extract and sophora flavescens root extract with acetyl hexapeptide-8 and palmitoyl pentapeptide-4 in a proper proportion to form the skin care composition. The applicant finds that the cream prepared from the skin care composition can effectively moisturize and improve the skin fineness and experience feeling, and the key point is that the moisturizing time can be obviously prolonged, and the anti-wrinkle effect is very obvious.
Detailed Description
In order that the invention may be more fully understood, reference will now be made to the following description. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The embodiment of the invention provides a skin care composition, which comprises the following components in percentage by mass (2-8): (0.5-5): (1-10) acetyl hexapeptide-8, palmitoyl pentapeptide-4, and plant extracts comprising stem extract of dendrobium nobile lindl, leaf extract of aloe barbadensis and root extract of sophora flavescens ait.
Preferably, the mass ratio of the acetyl hexapeptide-8, the palmitoyl pentapeptide-4 and the plant extract is (2-6): (1-5): (3-8).
Preferably, the mass ratio of the acetyl hexapeptide-8, the palmitoyl pentapeptide-4 and the plant extract is (2.5-4): (4-5): (5.5-7).
Preferably, the mass ratio of the dendrobium stem extract to the aloe barbadensis leaf extract to the sophora flavescens root extract is (1-4): (6-10): (5-7).
The embodiment of the invention also provides an application of the skin care composition in preparing a skin care product.
Preferably, the skin care product is a skin care cream. It is to be understood that the skin care composition is not limited to use in preparing a cream.
The embodiment of the invention also provides a skin-care cream, which comprises water and the following components in percentage by mass:
preferably, the other functional additives comprise the following components in percentage by mass:
preferably, the antioxidant is tocopherol acetate; or/and the chelating agent is disodium ETDA; or/and the pH regulator is potassium hydroxide; or/and the preservative is
K350; and/or, the anti-allergy agent is at least one of astragalus membranaceus root extract, divaricate saposhnikovia root extract, calendula officinalis extract, albizia julibrissin extract and gastrodia elata root extract.
The anti-allergy agent disclosed by the embodiment is good in allergy relieving, has the effects of soothing, relieving itching, dispelling redness, diminishing swelling and inhibiting release of inflammatory factors/mediators, has the effect of immediately relieving skin irritation, has a good anti-inflammatory and relieving effect, can effectively reduce skin allergy symptoms, repair skin barriers, is extremely mild, is safe and free of additives, has a good anti-allergy and relieving effect, and creates a long-acting and consolidated anti-allergy barrier for skin.
Preferably, the emulsifier is selected from at least one of cetyl alcohol, C20-22 alcohol phosphate and glyceryl monostearate; or/and the emollient is selected from at least one of behenyl alcohol, caprylic/capric triglyceride, isopropyl isostearate, dioctyl carbonate and polydimethylsiloxane; or/and the skin feel regulator is polymethyl methacrylate; the humectant is selected from at least one of glycerin and butanediol; or/and the thickening agent is carbomer.
Preferably, the emulsifier is prepared by mixing the following components in a mass ratio of (1-5): (0.2-3): (0.3-3) a combination of cetyl alcohol, C20-22 alcohol phosphate and glyceryl monostearate; the emollient is (0.5-4): (1-5): (2-7): (0.1-3): (1-6) a combination of behenyl alcohol, caprylic/capric triglyceride, isopropyl isostearate, dioctyl carbonate and polydimethylsiloxane. The application can further improve the permeability of the skin cream by optimizing the emulsifier and the emollient.
The embodiment of the invention also provides a preparation method of the skin care cream, which comprises the following steps:
(1) mixing emulsifier, emollient and skin feeling regulator to prepare phase A; mixing the moisturizing agent, the thickening agent, part of other functional additives and water to prepare a phase B;
(2) adding phase B into phase A, and mixing;
(3) mixing the other part of other functional additives with water to prepare a phase C, adding the phase C into the product obtained in the step (2), and mixing;
(4) mixing the rest of other functional adjuvants and the skin care composition to obtain phase D, adding the phase D into the product obtained in step (3), and mixing.
The raw materials used in the embodiment of the invention are all available in the market: novel A is selected as cetyl alcohol; novel P is selected as C20-22 alcohol phosphate; the glyceryl monostearate is Arlacel 165, and the caprylic/capric triglyceride is Crodamol GTCC; the anti-allergy agent is good in comfort and allergy; selection of antiseptic
K 350。
Example 1
The embodiment provides a skin-care cream which comprises the following components in percentage by mass:
phase A: 3.00 percent of Novel A, 0.20 percent of Novel P, 0.78 percent of Arlacel 1652.00 percent, 2.00 percent of behenyl alcohol, 2.50 percent of Crodamol GTCC, 3.00 percent of isopropyl isostearate, 0.60 percent of dioctyl carbonate, 6.00 percent of polydimethylsiloxane, 1.50 percent of polymethyl methacrylate and 0.60 percent of tocopheryl acetate;
phase B: 8.00% of glycerin, 2.00% of butanediol, 0.10% of ETDA disodium, 0.60% of carbomer and water (to 100%);
and C phase: 0.08 percent of potassium hydroxide and 1.50 percent of water;
phase D: acetyl hexapeptide-82.00%, palmitoyl pentapeptide-42.00%, Irriguard (Miyaura) 3.00%, plant extract 8.00%,
k3500.10% and essence 0.10%, wherein the plant extract is dendrobium stem extract, aloe barbadensis leaf extract and sophora flavescens root extract, and the mass ratio of the plant extract to the dendrobium stem extract is 1: 6: 5 in combination.
The preparation method of the skin-care cream comprises the following steps:
(1) heating the phase A component to 80 ℃, stirring and melting the phase A component into liquid, and preserving heat for later use;
(2) slowly scattering the powder raw materials in the phase B component into water, heating and dispersing uniformly while stirring, heating to 82 ℃ to completely dissolve uniformly, homogenizing at 1200r/min for 2 minutes until uniform, preserving heat, and defoaming for later use;
(3) starting homogenization, slowly adding the phase B component into the phase A component, homogenizing at 3000r/min for 3 minutes until complete and uniform emulsification is achieved, defoaming and cooling;
(4) cooling to 70 ℃, adding the C phase component, and homogenizing at 3000r/min for 2 minutes until the mixture is uniform;
(5) cooling to below 40 deg.C, sequentially adding phase D components, stirring thoroughly (homogenizing at 1000-1400r/min for 0.5-1 min);
the prepared cream is a light yellow paste;
the pH was measured to be 6.20 after dilution with water (1:10 aqueous solution);
viscosity (25 ℃, mpa.s): 37100 (rotor # 4, 6 rpm/min);
the heat resistance (45 plus or minus 2 ℃) is 2 months, the room temperature is recovered, and the phenomena of oil-water separation and coarsening are avoided;
cold resistance (-17 + -2 ℃): recovering room temperature for 2 months without oil-water separation and coarsening;
cycle test (45 ℃, ambient temperature, -17 ℃): and 5 cycles (standing at 45 ℃ for 24h, then transferring to normal temperature at normal temperature for 24h, finally standing at-17 ℃ for 24h, and circulating for 5 times) are qualified.
In the facial cream provided by the embodiment of the invention, through the use of the acetyl hexapeptide-8, the palmitoyl pentapeptide-4 and the plant extract, the facial cream can deeply moisturize and moisturize the skin, has an excellent moisturizing and moisturizing effect, can permanently moisturize the skin, and creates a good long-term moisturizing barrier for the skin; meanwhile, the skin moisturizing factor can be effectively stimulated to proliferate, so that the water content and the water locking degree of the skin are improved, the skin thickness is increased, fine lines are reduced, the skin is compacted and moistened, new wrinkles can be effectively prevented from being generated, the skin aging is reversed through reconstruction from inside to outside, the skin moisturizing cream has good anti-wrinkle effect and anti-aging activity, and the skin becomes finer and smoother.
Example 2
The embodiment provides a skin-care cream which comprises the following components in percentage by mass:
phase A: novel A2.00%, Novel P1.00%, Arlacel 1651.00%, behenyl alcohol 1.60%, Crodamol GTCC 3.00%, isopropyl isostearate 5.00%, dioctyl carbonate 2.00%, polydimethylsiloxane 3.00%, polymethyl methacrylate 1.00%, tocopheryl acetate 0.50%;
phase B: 3.00% of glycerin, 5.00% of butanediol, 0.05% of ETDA disodium, 0.30% of carbomer and water (to 100%);
and C phase: 0.133% of potassium hydroxide and 2.00% of water;
phase D: acetyl hexapeptide-86.00%, palmitoyl pentapeptide-43.50%, Irriguard (Sammari), plant extract 5.00%,
k3500.80% and essence 0.25%, wherein the plant extract is dendrobium stem extract, aloe barbadensis leaf extract and sophora flavescens root extract, and the mass ratio of the plant extract to the dendrobium stem extract is 3: 5: 6 in combination.
The preparation method of the skin-care cream comprises the following steps:
(1) heating the phase A component to 80 ℃, stirring and melting the phase A component into liquid, and preserving heat for later use;
(2) slowly scattering the powder raw materials in the phase B component into water, heating and dispersing uniformly while stirring, heating to 85 ℃ to completely dissolve uniformly, homogenizing at 1200r/min for 2 minutes until uniform, preserving heat, and defoaming for later use;
(3) starting homogenization, slowly adding the phase B component into the phase A component, homogenizing at 2800r/min for 5 minutes until complete and uniform emulsification is achieved, defoaming and cooling;
(4) cooling to 72 ℃, adding the phase C component, and homogenizing at 2800r/min for 2 minutes until uniform;
(5) cooling to below 40 ℃, sequentially adding the phase D components, and fully and uniformly stirring (the mixture can be weakly homogenized for 0.5-1 minute at 1000-1400r/min to be uniform);
the prepared cream is a light yellow paste;
the pH was measured to be 6.50 after dilution with water (1:10 aqueous solution);
viscosity (25 ℃, mpa.s): 37700 (rotor # 4, 6 rpm/min);
the heat resistance (45 plus or minus 2 ℃) is 2 months, the room temperature is recovered, and the phenomena of oil-water separation and coarsening are avoided;
cold resistance (-17 + -2 ℃): recovering room temperature for 2 months without oil-water separation and coarsening;
cycle test (45 ℃, ambient temperature, -17 ℃): and 5 cycles (standing at 45 ℃ for 24h, then transferring to normal temperature at normal temperature for 24h, finally standing at-17 ℃ for 24h, and circulating for 5 times) are qualified.
Example 3
The embodiment provides a skin-care cream which comprises the following components in percentage by mass:
phase A: novel A5.00%, Novel P0.80%, Arlacel 1651.50%, behenyl alcohol 3.00%, Crodamol GTCC 4.00%, isopropyl isostearate 6.00%, dioctyl carbonate 1.00%, polydimethylsiloxane 1.00%, polymethyl methacrylate 0.50%, and tocopheryl acetate 0.80%;
phase B: 1.00% of glycerin, 3.00% of butanediol, 0.08% of ETDA disodium, 2.00% of carbomer and water (to 100%);
and C phase: 0.20 percent of potassium hydroxide and 3.00 percent of water;
phase D: acetyl hexapeptide-83.00%, palmitoyl pentapeptide-45.00%, Irriguard (Miyaura) 0.80%, plant extract 6.00%,k3502.00% and essence 0.30%, wherein the plant extract is dendrobium stem extract, aloe barbadensis leaf extract and sophora flavescens root extract, and the mass ratio of the plant extract to the dendrobium stem extract is 1: 10: 7 in combination.
The preparation method of the skin-care cream comprises the following steps:
(1) heating the phase A component to 78 ℃, stirring and melting the phase A component into liquid, and preserving heat for later use;
(2) slowly scattering the powder raw materials in the phase B component into water, heating and dispersing uniformly while stirring, heating to 85 ℃ to completely dissolve uniformly, homogenizing at 1400r/min for 1 minute until uniform, preserving heat, and defoaming for later use;
(3) starting homogenization, slowly adding the phase B component into the phase A component, homogenizing at 3300r/min for 3 minutes until complete and uniform emulsification is achieved, defoaming, and cooling;
(4) cooling to 75 ℃, adding the C phase component, and homogenizing at 3300r/min for 1 minute until uniform;
(5) cooling to below 40 ℃, sequentially adding the phase D components, and fully and uniformly stirring (the mixture can be weakly homogenized for 0.5-1 minute at 1000-1400r/min to be uniform);
the prepared cream is a light yellow paste; the pH was measured to be 6.80 after dilution with water (1:10 aqueous solution);
viscosity (25 ℃, mpa.s): 37900 (rotor # 4, 6 rpm/min);
the heat resistance (45 plus or minus 2 ℃) is 2 months, the room temperature is recovered, and the phenomena of oil-water separation and coarsening are avoided;
cold resistance (-17 + -2 ℃): recovering room temperature for 2 months without oil-water separation and coarsening;
cycle test (45 ℃, ambient temperature, -17 ℃): and 5 cycles (standing at 45 ℃ for 24h, then transferring to normal temperature at normal temperature for 24h, finally standing at-17 ℃ for 24h, and circulating for 5 times) are qualified.
Example 4
The embodiment provides a skin-care cream which comprises the following components in percentage by mass:
phase A: novel A2.50%, Novel P2.00%, Arlacel 1650.10%, behenyl alcohol 0.80%, Crodamol GTCC 3.00%, isopropyl isostearate 7.00%, dioctyl carbonate 1.50%, polydimethylsiloxane 4.00%, polymethyl methacrylate 3.00%, tocopheryl acetate 0.20%;
phase B: 6.00% of glycerin, 1.00% of butanediol, 0.20% of ETDA disodium, 1.50% of carbomer and water (to 100%);
and C phase: 0.15 percent of potassium hydroxide and 2.00 percent of water;
phase D: acetyl hexapeptide-88.00%, palmitoyl pentapeptide-40.50%, Irriguard (Sammari) 2.00%, plant extract 1.00%,
k3501.00%, essence 0.05%Wherein the plant extract is dendrobium stem extract, aloe barbadensis leaf extract and sophora flavescens root extract, and the mass ratio of the plant extract to the dendrobium stem extract is 4: 6: 7 in combination.
The preparation method of the skin-care cream comprises the following steps:
(1) heating the phase A component to 78 ℃, stirring and melting the phase A component into liquid, and preserving heat for later use;
(2) slowly scattering the powder raw materials in the phase B component into water, heating and dispersing uniformly while stirring, heating to 82 ℃ to completely dissolve uniformly, homogenizing at 1000r/min for 2 minutes until uniform, preserving heat, and defoaming for later use;
(3) starting homogenization, slowly adding the phase B component into the phase A component, homogenizing at 3000r/min for 5 minutes until complete emulsification is uniform, defoaming, and cooling;
(4) cooling to 70 ℃, adding the C phase component, and homogenizing at 3000r/min for 2 minutes until the mixture is uniform;
(5) cooling to below 40 ℃, sequentially adding the phase D components, and fully and uniformly stirring (the mixture can be weakly homogenized for 0.5-1 minute at 1000-1400r/min to be uniform);
the prepared cream is a light yellow paste; the pH was measured to be 6.30 after dilution with water (1:10 aqueous solution);
viscosity (25 ℃, mpa.s): 37500(4# rotor, 6 rpm/min);
the heat resistance (45 plus or minus 2 ℃) is 2 months, the room temperature is recovered, and the phenomena of oil-water separation and coarsening are avoided;
cold resistance (-17 + -2 ℃): recovering room temperature for 2 months without oil-water separation and coarsening;
cycle test (45 ℃, ambient temperature, -17 ℃): and 5 cycles (standing at 45 ℃ for 24h, then transferring to normal temperature at normal temperature for 24h, finally standing at-17 ℃ for 24h, and circulating for 5 times) are qualified.
Example 5
The embodiment provides a skin-care cream which comprises the following components in percentage by mass:
phase A: novel A4.00%, Novel P1.50%, Arlacel 1653.00%, behenyl alcohol 4.00%, Crodamol GTCC 1.00%, isopropyl isostearate 2.00%, dioctyl carbonate 0.10%, polydimethylsiloxane 2.00%, polymethyl methacrylate 2.00%, tocopheryl acetate 1.00%;
phase B: 2.00% of glycerin, 7.00% of butanediol, 0.02% of ETDA disodium, 1.00% of carbomer and water (to 100%);
and C phase: 0.05 percent of potassium hydroxide and 0.50 percent of water;
phase D: acetyl hexapeptide-85.00%, palmitoyl pentapeptide-43.00%, Irriguard (Miyaura) 0.20%, plant extract 10.00%,k3500.60% and essence 0.20%, wherein the plant extract is dendrobium stem extract, aloe barbadensis leaf extract and sophora flavescens root extract, and the mass ratio of the plant extract to the dendrobium stem extract is 4: 6: 5 in combination.
The preparation method of the skin-care cream comprises the following steps:
(1) heating the phase A component to 80 ℃, stirring and melting the phase A component into liquid, and preserving heat for later use;
(2) slowly scattering the powder raw materials in the phase B component into water, heating and dispersing uniformly while stirring, heating to 85 ℃ to completely dissolve uniformly, homogenizing at 1400r/min for 1 minute until uniform, preserving heat, and defoaming for later use;
(3) starting homogenization, slowly adding the phase B component into the phase A component, homogenizing at 3200r/min for 3 minutes until complete and uniform emulsification is achieved, and reducing the temperature after defoaming;
(4) cooling to 72 ℃, adding the phase C component, and homogenizing at 3200r/min for 2 minutes until the phase C component is uniform;
(5) cooling to below 40 ℃, sequentially adding the phase D components, and fully and uniformly stirring (the mixture can be weakly homogenized for 0.5-1 minute at 1000-1400r/min to be uniform);
the prepared cream is a light yellow paste; the pH was measured to be 6.10 after dilution with water (1:10 aqueous solution);
viscosity (25 ℃, mpa.s): 37200 (rotor # 4, 6 rpm/min);
the heat resistance (45 plus or minus 2 ℃) is 2 months, the room temperature is recovered, and the phenomena of oil-water separation and coarsening are avoided;
cold resistance (-17 + -2 ℃): recovering room temperature for 2 months without oil-water separation and coarsening;
cycle test (45 ℃, ambient temperature, -17 ℃): and 5 cycles (standing at 45 ℃ for 24h, then transferring to normal temperature at normal temperature for 24h, finally standing at-17 ℃ for 24h, and circulating for 5 times) are qualified.
Example 6
The embodiment provides a skin-care cream which comprises the following components in percentage by mass:
phase A: novel A1.00%, Novel P3.00%, Arlacel 1650.60%, behenyl alcohol 0.50%, Crodamol GTCC 5.00%, isopropyl isostearate 4.00%, dioctyl carbonate 3.00%, polydimethylsiloxane 3.00%, polymethyl methacrylate 0.80%, tocopheryl acetate 0.10%;
phase B: 5.00% of glycerin, 6.00% of butanediol, 0.15% of ETDA disodium, 0.10% of carbomer and water (to 100%);
and C phase: 0.10 percent of potassium hydroxide and 1.00 percent of water;
phase D: acetyl hexapeptide-86.00%, palmitoyl pentapeptide-41.00%, Irriguard (Miyaura), plant extract 3.00%,
k3501.50% and essence 0.50%, wherein the plant extract is dendrobium stem extract, aloe barbadensis leaf extract and sophora flavescens root extract, and the mass ratio of the plant extract to the dendrobium stem extract is 1: 10: 5 in combination.
The preparation method of the skin-care cream comprises the following steps:
(1) heating the phase A component to 78 ℃, stirring and melting the phase A component into liquid, and preserving heat for later use;
(2) slowly scattering the powder raw materials in the phase B component into water, heating and dispersing uniformly while stirring, heating to 85 ℃ to completely dissolve uniformly, homogenizing at 1000r/min for 2 minutes until uniform, preserving heat, and defoaming for later use;
(3) starting homogenization, slowly adding the phase B component into the phase A component, homogenizing at 3200r/min for 3 minutes until complete and uniform emulsification is achieved, and reducing the temperature after defoaming;
(4) cooling to 75 ℃, adding the C phase component, and homogenizing at 3200r/min for 1 minute until the mixture is uniform;
(5) cooling to below 40 ℃, sequentially adding the phase D components, and fully and uniformly stirring (the mixture can be weakly homogenized for 0.5-1 minute at 1000-1400r/min to be uniform);
the prepared cream is a light yellow paste; the pH was measured to be 6.50 after dilution with water (1:10 aqueous solution);
viscosity (25 ℃, mpa.s): 37600 (rotor # 4, 6 rpm/min);
the heat resistance (45 plus or minus 2 ℃) is 2 months, the room temperature is recovered, and the phenomena of oil-water separation and coarsening are avoided;
cold resistance (-17 + -2 ℃): recovering room temperature for 2 months without oil-water separation and coarsening;
cycle test (45 ℃, ambient temperature, -17 ℃): and 5 cycles (standing at 45 ℃ for 24h, then transferring to normal temperature at normal temperature for 24h, finally standing at-17 ℃ for 24h, and circulating for 5 times) are qualified.
TABLE 1
Example 7
This example is a modification of example 2, and is modified from example 2 only in that the mass ratio of the plant extract is 0.5:5: 8.
Example 8
This embodiment is a modification of embodiment 2, and the modification is only to embodiment 2:
the mass percentages of the cetyl alcohol, the C20-22 alcohol phosphate and the glycerin monostearate are respectively 0.1 percent, 3.2 percent and 0.7 percent.
The mass percentages of the behenyl alcohol, the caprylic/capric triglyceride, the isopropyl isostearate, the dioctyl carbonate and the polydimethylsiloxane are 6 percent, 0.5 percent, 1 percent, 3.1 percent and 5 percent.
Comparative example 1
The cream of this comparative example was the same as the cream of example 2 except that the cream of this comparative example was not added with acetyl hexapeptide-8.
Comparative example 2
The cream of this comparative example was the same as the cream of example 2 except that palmitoyl pentapeptide-4 was not added to the cream of this comparative example.
Comparative example 3
The cream of this comparative example was the same as the cream of example 2, except that the cream of this comparative example was not added with the plant extract.
Comparative example 4
The cream of this comparative example is the same as the cream of example 2, except that the plant extract does not contain the extract of sophora flavescens ait.
Comparative example 5
The cream of the present comparative example is the same as the cream of example 2, except that the mass percentages of acetyl hexapeptide-8, palmitoyl pentapeptide-4, and the plant extract in the cream of the present comparative example are 1%, 13%, and 0.5%, respectively.
Physical and chemical index test one
130 healthy skin volunteers were randomly selected for testing, and a group of example samples was tested every 10 persons, with each group being a unit, and the test results were averaged.
The moisturizing creams of examples 1-8 and the creams of comparative examples 1-5 were tested for use by applying 3 times daily for 30 consecutive days in the morning, at noon and at night.
1. The moisture content before and after use was measured using a skin moisture tester, and the% moisture content increase before and after use was calculated by the following method: skin moisture lifting rate (skin moisture content measured after use-skin moisture content measured before use)/skin moisture content before use × 100%.
2. The skin fineness and wrinkle change are measured by a skin detector, specifically a Visia skin detector; the fineness raising rate is obtained by the following calculation method: the fineness increase rate is (skin fineness measured after use-skin fineness measured before use)/skin fineness measured before use × 100%.
3. The total score of experience score is 10 points, 8-10 points are good, 6-8 points are general, and 6 points and below are poor experience.
The test results are shown in tables 2, 3 and 4.
TABLE 2
Regarding the wrinkle-reducing effect of the cream, it can be seen from the data of table 2 that: (1) the effects of examples 1 to 7 in reducing wrinkles are overall superior to the comparative example. This demonstrates that the rational arrangement of acetyl hexapeptide-8, palmitoyl pentapeptide-4 and plant extracts in the cream formulation of the present invention is of paramount importance. (2) In the whole example, the effect of the example 2 is the best, namely the example 1, the example 3 and the example 6, and meanwhile, the effects of the examples 1 to 6 are better compared with the example 7 on the whole, which shows that the cream formula provided by the invention has a preferable formula.
TABLE 3
Regarding the improvement of moisture content, fineness and use experience of the skin by the face cream, the data in table 3 show that: (1) the effects of examples 1 to 7 are overall superior to those of the comparative example. This demonstrates that the rational arrangement of acetyl hexapeptide-8, palmitoyl pentapeptide-4 and plant extracts in the cream formulation of the present invention is of paramount importance. (2) In the whole example, the effect of the example 2 is the best, namely the example 1, the example 3 and the example 6, and meanwhile, the effects of the examples 1 to 6 are better compared with the example 7 on the whole, which shows that the cream formula provided by the invention has a preferable formula.
After the use, the test product is stopped from being used and other moisturizing products are not used, and a return visit test is carried out after 2 weeks to test the moisturizing retention rate. The retention was calculated by: moisture retention rate is skin moisture content measured after 2 weeks/skin moisture content measured immediately after use × 100%.
TABLE 4
| Test items | Moisture retention after 2 weeks/%) |
| Example 1 | 88.1 |
| Example 2 | 93.2 |
| Example 3 | 86.4 |
| Example 4 | 85.8 |
| Example 5 | 86.3 |
| Example 6 | 87.5 |
| Example 7 | 83.8 |
| Comparative example 1 | 82.6 |
| Comparative example 2 | 26.3 |
| Comparative example 3 | 33.1 |
| Comparative example 4 | 79.2 |
| Comparative example 5 | 80.3 |
Regarding the long-lasting moisturizing effect of the cream, it can be seen from the data in table 4 that: (1) the effects of examples 1 to 7 are overall superior to those of the comparative example. This demonstrates that the rational arrangement of acetyl hexapeptide-8, palmitoyl pentapeptide-4 and plant extracts in the cream formulation of the present invention is of paramount importance. (2) In the whole example, the effect of the example 2 is the best, namely the example 1, the example 3 and the example 6, and meanwhile, the effects of the examples 1 to 6 are better compared with the example 7 on the whole, which shows that the cream formula provided by the invention has a preferable formula.
Physical and chemical index test II and permeability test experiment
In the using process of the cream, the palmitoyl pentapeptide-4 penetrates deeply into the dermis tissue, acts on skin fibroblasts, promotes the synthesis of collagen, effectively reverses the aging and reduces wrinkles, so the palmitoyl pentapeptide-4 is used as a test object of permeability.
(1) Taking 8 Kunming mice with similar body weight (within the range of 30-35 g), numbering 1-8, and depilating the skin of the chest and abdomen of the mice with 6 wt% of sodium sulfide;
(2) three random positions (2.0mm multiplied by 1.5mm) are confirmed at the chest and abdomen of the No. 1-10 mice, wherein, 1.0g of the corresponding cream sample is coated at two positions, and 1.0g of the palmitoyl pentapeptide-4 sample is directly coated at the other position;
(3)1 hour later, the neck of the mouse is cut off and the mouse is killed, the chest and abdomen skin coated with the cream sample and the palmitoyl pentapeptide-4 sample is taken down, and the chest and abdomen skin which is not coated with the cream sample and has the same size is taken as a blank control group;
(4) removing epidermis from the chest and abdomen skin of the mouse, grinding the dermal tissue to be chyle, adding 5mL of absolute ethyl alcohol, mixing, centrifuging at 8000r/min for 15min, collecting the supernatant, and purifying with LC-9A high performance liquid chromatograph (Shimadzu, Japan) [ C18 column as chromatographic column, at 25 deg.C, with ethanol as mobile phase: the content of palmitoyl pentapeptide-4 was determined at a flow rate of 1.0mL/min and a detection wavelength of 224nm with water of 10: 90.
The results of the permeability test are shown in table 5, wherein the content of the blank control group is 0%, the content of the sample coated with palmitoyl pentapeptide-4 is 100%, and the results are the average value of the test results of dermal tissues of two different parts.
TABLE 5
| Test items | Permeability of |
| Example 1 | 63.6％ |
| Example 2 | 68.2％ |
| Example 3 | 62.4％ |
| Example 4 | 64.5％ |
| Example 5 | 66.8％ |
| Example 6 | 58.6％ |
| Example 7 | 60.3％ |
| Example 8 | 56.1％ |
Regarding the penetration effect of the cream, it can be seen from the data in table 5: the permeation effect of examples 1 to 8 is overall superior. Also, the permeability of examples 1-7 is generally better than that of example 8, indicating that there is a preference for the choice of emulsifier and emollient in the formulations of the present invention.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. A skin care composition is characterized by comprising the following components in a mass ratio of (2-8): (0.5-5): (1-10) acetyl hexapeptide-8, palmitoyl pentapeptide-4, and plant extracts comprising stem extract of dendrobium nobile lindl, leaf extract of aloe barbadensis and root extract of sophora flavescens ait.
2. The skin care composition according to claim 1, wherein the mass ratio of the dendrobium stem extract, the aloe barbadensis leaf extract and the sophora flavescens root extract is (1-4): (6-10): (5-7).
3. Use of a skin care composition according to claim 1 or 2 in the preparation of a skin care product.
4. Use according to claim 3, wherein the skin care product is a skin care cream.
5. The skin-care cream is characterized by comprising water and the following components in percentage by mass:
6. the skin-care cream according to claim 5, wherein the other functional auxiliary agents comprise the following components in percentage by mass:
7. the skin cream of claim 6, wherein the antioxidant is tocopheryl acetate; or/and the chelating agent is disodium ETDA; or/and the pH regulator is potassium hydroxide; or/and the preservative isK350; and/or, the anti-allergy agent is at least one of astragalus membranaceus root extract, divaricate saposhnikovia root extract, calendula officinalis extract, albizia julibrissin extract and gastrodia elata root extract.
8. The skin cream according to any one of claims 5 to 7, wherein the emulsifier is selected from at least one of cetyl alcohol, C20-22 alcohol phosphate and glyceryl monostearate; or/and the emollient is selected from at least one of behenyl alcohol, caprylic/capric triglyceride, isopropyl isostearate, dioctyl carbonate and polydimethylsiloxane; or/and the skin feel regulator is polymethyl methacrylate; the humectant is selected from at least one of glycerin and butanediol; or/and the thickening agent is carbomer.
9. The skin care cream according to claim 8, wherein the emulsifier is present in a mass ratio of (1-5): (0.2-3): (0.3-3) a combination of cetyl alcohol, C20-22 alcohol phosphate and glyceryl monostearate; the emollient is (0.5-4): (1-5): (2-7): (0.1-3): (1-6) a combination of behenyl alcohol, caprylic/capric triglyceride, isopropyl isostearate, dioctyl carbonate and polydimethylsiloxane.
10. A method of making a skin cream according to any one of claims 5 to 7, characterised in that the method comprises the steps of:
(1) mixing the emulsifier, the emollient and the skin feel modifier to prepare a phase A; mixing the moisturizing agent, the thickening agent, part of other functional additives and water to prepare a phase B;
(2) adding the phase B to the phase A and mixing;
(3) mixing the other part of the other functional auxiliary agents with water to prepare a phase C, adding the phase C into the product obtained in the step (2), and mixing;
(4) mixing the rest of other functional adjuvants with the skin care composition of claim 1 or 2 to prepare phase D, adding the phase D to the product obtained in step (3), and mixing.
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