CN104027280A - Anti-aging traditional Chinese medicine composition and application of anti-aging traditional Chinese medicine composition in cosmetics - Google Patents
Anti-aging traditional Chinese medicine composition and application of anti-aging traditional Chinese medicine composition in cosmetics Download PDFInfo
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Abstract
The invention discloses an anti-aging traditional Chinese medicine composition. The anti-aging traditional Chinese medicine composition comprises, by weight, 10-50% of mistletoe, 5-25% of witch hazel, 5-30% of sea buckthorn, 3-25% of eleutherococcus senticosus and 5-25% of liquorice. In the anti-aging traditional Chinese medicine composition, alcohol with the volume fraction of 10%-70% is used as an extraction solvent; a concentrated solution obtained through heating, extraction and concentration is subjected to purification through macroporous resin columns; repeated elution is conducted through alcohol with the volume fraction ranging from 30% to 90%; the eluent is dissolved and filtered through 1,3-butanediol after being subjected to decompression concentration, and then extractives of the traditional Chinese medicine composition can be obtained. The extractives of the traditional Chinese medicine composition can be applied to cosmetics and have the good effects of promoting growth of skin cells, scavenging free radicals, improving skin microcirculation, whitening the skin and increasing skin elasticity, thereby resisting skin aging.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and the application in cosmetics thereof, relate in particular to a kind of delay aging drug compositions and the application in cosmetics thereof.
Background technology
Along with raising and the Chinese society of people's living standard are stepped into aging gradually, defying age is more and more subject to people's attention.
Aging is the direct performance that function of human body slows down, and is the process that the function of health each several part tract fails gradually, is also a kind of naturally process.Cause that old and feeble reason is very complicated, sum up and mainly contain endogenous cause of ill and two aspects of exopathogenic factor.Endogenous cause of ill is main and hereditary, endocrine is relevant, and exopathogenic factor is mainly that the human free radical that environment causes raises, and breaks the balance between free-radical generating and extinction, causes disease to produce and aging.
Skin aging is a kind of imbody of human senility, is embodied in and occurs wrinkle, speckle, the feature such as dry.Prevent skin aging should be from Promote cell's growth, remove free radical, improve the aspects such as skin microcirculation and set about.
Prevention and delay skin aging are the important topics of cosmetic dermatology.Development effectiveness is obvious, safe, stable, the activity of fighting against senium thing of good absorbing, has become the focus of current beauty industry.Natural materials is applied to cosmetics can reach skin treating and skin protection double effects, and has diverse in function, the characteristic such as widely applicable, safe, so the old and feeble active matter of natural Traditional Chinese Medicine Anti is defying age main direction of studying.
Summary of the invention
Object of the present invention is just to provide a kind of preparation method of Chinese medicine composition and this Chinese medicine composition extract with potent senile-resistant efficacy.
To achieve the object of the present invention, the present invention has adopted following technical scheme:
There is a Chinese medicine composition for senile-resistant efficacy, it is characterized in that the component that comprises following percentage by weight: Herba Visci 10-50%, Radix Hamamelidis Mollis 5-25%, Fructus Hippophae 5-30%, Radix Et Caulis Acanthopanacis Senticosi 3-25%, Radix Glycyrrhizae 5-25%.
Preferably, described in, have senile-resistant efficacy Chinese medicine composition (
i) percentage by weight is: Herba Visci 32%, Radix Hamamelidis Mollis 16%, Fructus Hippophae 16%, Radix Et Caulis Acanthopanacis Senticosi 14%, Radix Glycyrrhizae 22%.
Preferably, described in, have senile-resistant efficacy Chinese medicine composition (
iI) percentage by weight is: Herba Visci 28%, Radix Hamamelidis Mollis 20%, Fructus Hippophae 20%, Radix Et Caulis Acanthopanacis Senticosi 16%, Radix Glycyrrhizae 16%.
Preferably, described in, have senile-resistant efficacy Chinese medicine composition (
iII) percentage by weight is: Herba Visci 34%, Radix Hamamelidis Mollis 18%, Fructus Hippophae 18%, Radix Et Caulis Acanthopanacis Senticosi 15%, Radix Glycyrrhizae 15%.
The preparation method of above-mentioned delay aging drug compositions extract, it is characterized in that: above-mentioned Chinese medicine composition is pulverized, mix homogeneously after sieving, be in 10% ~ 70% ethanol for 1:5 ~ 1:20 joins volume fraction in mass ratio, 50 ~ 80 DEG C of heating extraction 1 ~ 3h, extract 1 ~ 3 time, filter, merging filtrate, be evaporated to without alcohol taste, go up again macroporous resin column purification, with volume fraction be repeatedly eluting of 30% ~ 90% ethanol, collect eluent, the mass ratio that is evaporated to extracting solution and Chinese medicine is 1:0.5 ~ 1:10, add again with concentrated after the 1.3-butanediol of the same weight of extracting solution dissolve, filter, make Chinese medicine composition extract.
The second object of the present invention be by the extract of above-mentioned delay aging drug compositions for anti-aging cosmetics, make stable in properties, respond well anti-aging cosmetics.
For realizing the second object of the present invention, the present invention has adopted following technical scheme: the extract of above-mentioned Chinese medicine composition is used for to preparing cosmetics, it is characterized in that containing above-mentioned Chinese medicine composition extract in cosmetics, its consumption is 0.1-25%, and preferable amount is 2-10%.
Beneficial effect of the present invention: the present invention carries out the design of Chinese medicine composition according to the theory of Chinese medical science of monarch.Herba Visci in Chinese medicine composition of the present invention is monarch drug, and Herba Visci contains abundant flavone compound, has very strong antioxidation and effect of scavenging radical; Fructus Hippophae and Radix Et Caulis Acanthopanacis Senticosi are ministerial drug, both all have effect of blood circulation promoting and blood stasis dispelling, and the oxidation-resistant active ingredient such as a large amount of vitamin Es, vitamin A, flavone and SOD of containing in Fructus Hippophae, in Radix Et Caulis Acanthopanacis Senticosi, containing a large amount of carotene, SOD and vitamin, can effectively remove
free radicalto reach antidotal effect; Radix Hamamelidis Mollis is adjuvant drug, and Radix Hamamelidis Mollis contains abundant tannin matter class material, has the sebum secretion of adjusting, antiallergic, convergence, moisturizing and whitening function; Radix Glycyrrhizae is for making medicine, and coordinating the actions of various ingredients in a prescription, has heat-clearing and toxic substances removing, skin-active granulation promoting and whitening, anti-inflammatory efficacy.All medicines share above, and Synergistic has good Promote cell's growth, removes free radical, improves skin microcirculation, effect of whitening and raising skin elasticity, thereby reaches skin anti-aging object.
Brief description of the drawings
Accompanying drawing 1 is the comparison diagram that uses the skin elasticity of defying age sleep facial film and common sleep facial film;
Accompanying drawing 2 is the comparison diagrams that use the dermal melanin content of defying age sleep facial film and common sleep facial film.
Detailed description of the invention
The present invention will be described in more detail to enumerate embodiment below, but technical scope of the present invention is not limited by these embodiment.All proportional quantities all by weight percentage below.
embodiment 1 Chinese medicine composition extract (I) and preparation method
Take raw material of Chinese medicine Herba Visci 32g, Radix Hamamelidis Mollis 16g, Fructus Hippophae 16g, Radix Et Caulis Acanthopanacis Senticosi 14g, Radix Glycyrrhizae 22g by proportioning; Above-mentioned Chinese medicine composition is pulverized, and mix homogeneously after sieving, is in 30% ethanol for 1:10 joins volume fraction in mass ratio, 60 DEG C of heating extraction 1 ~ 3h, extract 2 times, filter, merging filtrate, is evaporated to without alcohol taste, upper AB-8 macroporous resin column purification, with volume fraction be repeatedly eluting of 30%, 50%, 70% ethanol, collect eluent, being evaporated to extracting solution is 50mL, then adds 1.3-butanediol 100mLmL to dissolve, filter, make Chinese medicine composition extract.
embodiment 2 Chinese medicine composition extract (II) and preparation methoies
Take raw material of Chinese medicine Herba Visci 28g, Radix Hamamelidis Mollis 20g, Fructus Hippophae 20g, Radix Et Caulis Acanthopanacis Senticosi 16g, Radix Glycyrrhizae 16g by proportioning; Above-mentioned Chinese medicine composition is pulverized, and mix homogeneously after sieving, is in 30% ethanol for 1:10 joins volume fraction in mass ratio, 60 DEG C of heating extraction 1 ~ 3h, extract 2 times, filter, merging filtrate, is evaporated to without alcohol taste, upper AB-8 macroporous resin column purification, with volume fraction be repeatedly eluting of 20%, 50%, 80% ethanol, collect eluent, being evaporated to extracting solution is 50mL, then adds 1.3-butanediol 50mL to dissolve, filter, make 100mL Chinese medicine composition extract.
the preparation of comparative example 1-5 single medicinal material extract
Take respectively raw material of Chinese medicine Herba Visci 100g, Radix Hamamelidis Mollis 100g, Fructus Hippophae 100g, Radix Et Caulis Acanthopanacis Senticosi 100g, Radix Glycyrrhizae 100g, above-mentioned Chinese medicine is pulverized respectively, sieve, the volume fraction that joins 2L is in 75% ethanol, twice of 80 DEG C of heating extraction, each extraction 2 hours, remove by filter after medicine residue, merging filtrate, at 60 DEG C, be evaporated to without alcohol taste, above extracting solution is gone up AB-8 macroporous resin column purification again, with volume fraction be 30%, 50%, repeatedly eluting of 70% ethanol, collect eluent, being evaporated to extracting solution is 50mL, add again 1.3-butanediol 50mL to dissolve, filter, make respectively 100mL Radix Glycyrrhizae extract, Herba Visci extracting solution, Radix Hamamelidis Mollis extracting solution, Fructus Hippophae extracting solution, acanthopanax senticosus extract.
embodiment 3 defying age sleep facial films
Table 1 provides the defying age sleep surface film formulation that contains Chinese medicine composition extract of the present invention.
Table 1
Preparation method:
1, by interpolation phase raw material methyl hydroxybenzoate and propylparaben in advance in 1.3-butanediol heating for dissolving to clear, for subsequent use.
2, water raw material is fed in deionized water, is heated to 75 ~ 85 DEG C, be stirred to and be uniformly dissolved.
3, water is cooled to 60 DEG C, slowly adds while stirring the methyl hydroxybenzoate, propylparaben and the 1.3-butanediol that have dissolved in advance, is stirred to and is uniformly dissolved.
4, be cooled to 40 DEG C, add Chinese medicine composition extract (I), then drip aminomethyl propanol adjusting pH value to 5 ~ 6.
5, stir, be cooled to 35 DEG C, discharging, packs after ageing 24h.
the common sleep facial film of comparative example 6
Table 2 provides the anti-common sleep surface film formulation that does not contain Chinese medicine composition extract of the present invention.
Table 2
Preparation method:
1, by interpolation phase raw material methyl hydroxybenzoate and propylparaben in advance in 1.3-butanediol heating for dissolving to clear, for subsequent use.
2, water raw material is fed in deionized water, is heated to 75 ~ 85 DEG C, be stirred to and be uniformly dissolved.
3, water is cooled to 60 DEG C, slowly adds while stirring the methyl hydroxybenzoate, propylparaben and the 1.3-butanediol that have dissolved in advance, is stirred to and is uniformly dissolved.
4, be cooled to 40 DEG C, add Chinese medicine composition extract (I), then drip aminomethyl propanol adjusting pH value to 5 ~ 6.
5, stir, be cooled to 35 DEG C, discharging, packs after ageing 24h.
embodiment 4 anti-aging and nutritive frosts
Table 3 provides the anti-aging and nutritive frost formula that contains compound Chinese medicine extract of the present invention.
Table 3
Preparation method: A is 80 DEG C of dissolving mix homogeneously mutually, and B is 80 DEG C of dissolving mix homogeneously mutually, add B phase before Cyclomethicone emulsifying, when emulsifying, B is added to A mutually and homogenizing 5min, adds C phase homogenizing 2 minutes, discharging while being cooled to 50 DEG C, after ageing 24h, pack.
experimental example 1 extract anti-senescence function in-vitro evaluation
1, the preparation of sample
Single medicinal material extract prepared by Chinese medicine composition extract (I) prepared by embodiment 1 and comparative example 1-5, as sample solution, carries out in-vitro evaluation experiment.
2, the mensuration of restraint of tyrosinase vigor
According to table 4 application of sample, solution is placed in to 30 DEG C of water-bath constant temperature 10min; Add tryrosinase, solution is placed in after 30 DEG C of water-bath constant temperature 10min, under 475nm, measure its absorbance.
Table 4
| Blank (ml) | Blank (ml) | Sample contrast (ml) | Sample (ml) | |
| Sample | - | - | 1.0 | 1.0 |
| PBS(pH=6.8) | 2.5 | 2.0 | 1.5 | 1.0 |
| TYR | 1.0 | 1.0 | 1.0 | 1.0 |
| Tryrosinase | - | 0.5 | - | 0.5 |
| Total amount | 3.5 | 3.5 | 3.5 | 3.5 |
By the relative inhibition of formula (1) calculation sample to tryrosinase (
i, be called for short suppression ratio, lower same).
I=[(A1-A2)-(A3-A4)]×100%÷(A1-A2) （1）
In formula: A1, A2, A3, A4 are respectively the absorbance of 1 group～4 groups of solution.
3, the mensuration of ultra-oxygen anion free radical scavenging action
Get the Tris-HCl buffer 4.5mL of 0.05mol/L pH=8.2, preheating 20min in 25 DEG C of water-baths.Add again the pyrogallol solution of 1mL sample and 0.4mL 25mmol/L, after mixing, in 25 DEG C of water-baths, react 5min, add the HCl 1.0mL cessation reaction of 8mol/L.Make reference with Tris-HCl buffer, survey absorbance at 299nm place.Blank substitutes sample with the solvent of 1mL sample.Calculate clearance rate (D) according to formula (2).
O
2clearance rate=[1-(A6/ A5)] × 100% (2)
In formula: the absorbance that A5 is blank; A6 is the absorbance of medicine.
4, the removing ability of hydroxy radical is measured
In 25mL color comparison tube, add successively 2mmol/L FeSO
43mL, 1mmol/L H
2o
23mL, shakes up, and then adds 6mmol/L salicylic acid 3mL, shakes up, and after 37 DEG C of heating in water bath 15min, takes out, and surveys its absorbance; Add respectively certain density liquid to be measured, shake up, continue heating in water bath 15min, take out and survey its absorbance.Following formula is the clearance rate of liquid to be measured to carboxylic free radical (OH):
OH clearance rate (%)=[A7-A8-(A7-A9)] ∕ A7 × 100% (3)
In formula: A7 is the absorbance that does not add the front reaction system of medicine; A8 is the absorbance of system after medicine removing OH; A9 is the absorbance of system after blank removing OH.
5, experimental result
Anti-senescence function evaluation experimental is as shown in table 5.
Table 5 experimental result
Experiment shows, the Chinese medicine composition of the present invention active effect with removing free radical of restraint of tyrosinase effectively, and also also stronger than the effect of single medicinal material extract, illustrate and after compound recipe, played synergistic function.
experimental example 2 defying age sleep facial film effect human body evaluation tests
1, experimental technique
Sleep facial film prepared by embodiment 3 and comparative example 6 carries out respectively human body evaluation on probation, tests according to " cosmetics health specification " (version in 2007).Choose 30-50 year healthy, without 40 of the volunteers (10 male, 30 women) of cosmetic allergic contact dermatitis history.Using method is to use after clean of every day, (before sleep in evening) once a day, and left face uses the defying age of preparing by embodiment 3 facial film of sleeping, and right face uses the common sleep facial film of preparing by comparative example 6.Experiment periods is one month, the skin elasticity of results of regular determination volunteer face and dermal melanin, and after using one month, the colour of skin of left face and right face is carried out to paired observation.
2, experimental result
Accompanying drawing 1 is the comparison diagram that uses the skin elasticity of defying age sleep facial film and common sleep facial film;
Accompanying drawing 2 is the comparison diagrams that use the dermal melanin content of defying age sleep facial film and common sleep facial film.
The testing result of accompanying drawing 1 and accompanying drawing 2 shows, the skin whitening of defying age sleep facial film prepared by embodiment 3 and the effect that strengthens skin elasticity are obviously better than common sleep facial film prepared by comparative example 6.
Use after one month volunteer's face is observed and found, the colour of skin of the left face of the defying age sleep facial film that has 36 user to use to prepare by embodiment 3 is significantly better than the colour of skin of right face that has used the common sleep facial film of preparing by comparative example 6, and effective percentage reaches 90%.
Claims (2)
1. a delay aging drug compositions, is characterized in that the component that comprises following percentage by weight: Herba Visci 10-50%, Radix Hamamelidis Mollis 5-25%, Fructus Hippophae 5-30%, Radix Et Caulis Acanthopanacis Senticosi 3-25%, Radix Glycyrrhizae 5-25%, the extract manufacture method of Chinese medicine composition extract is: above-mentioned Chinese medicine composition is pulverized, mix homogeneously after sieving, be in 10% ~ 70% ethanol for 1:5 ~ 1:20 joins volume fraction in mass ratio, 50 ~ 80 DEG C of heating extraction 1 ~ 3h, extract 1 ~ 3 time, filter, merging filtrate, be evaporated to without alcohol taste, go up again macroporous resin column purification, with volume fraction be repeatedly eluting of 30% ~ 90% ethanol, collect eluent, the mass ratio that is evaporated to extracting solution and Chinese medicine is 1:0.5 ~ 1:10, add again with concentrated after the 1.3-butanediol of the same weight of extracting solution dissolve, filter, make the extract of Chinese medicine composition.
2. the application of the extract of a kind of delay aging drug compositions claimed in claim 1 in cosmetics, is characterized in that containing above-mentioned Chinese medicine composition extract in cosmetics, and its consumption is 0.1-25%, and preferable amount is 2-10%.
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Cited By (5)
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| CN105168040A (en) * | 2015-08-18 | 2015-12-23 | 广东轻工职业技术学院 | Composite anti-ageing skin-care composition and manufacturing method |
| CN105769672A (en) * | 2016-03-28 | 2016-07-20 | 四川力久知识产权服务有限公司 | Anti-aging composition for cosmetics |
| CN110384645A (en) * | 2019-09-06 | 2019-10-29 | 广州留今科学研究有限公司 | A kind of crease-resistant skin conditioning agent, U.S. restructuring compound for the neck and preparation method |
| CN113576970A (en) * | 2021-08-09 | 2021-11-02 | 科丝美诗(中国)化妆品有限公司 | Anti-aging plant extract composition and preparation and application thereof |
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| CN105769672A (en) * | 2016-03-28 | 2016-07-20 | 四川力久知识产权服务有限公司 | Anti-aging composition for cosmetics |
| CN110384645A (en) * | 2019-09-06 | 2019-10-29 | 广州留今科学研究有限公司 | A kind of crease-resistant skin conditioning agent, U.S. restructuring compound for the neck and preparation method |
| CN110384645B (en) * | 2019-09-06 | 2022-05-17 | 广州留今科学研究有限公司 | Anti-wrinkle skin conditioner, neck beautifying cream and preparation method |
| CN113576970A (en) * | 2021-08-09 | 2021-11-02 | 科丝美诗(中国)化妆品有限公司 | Anti-aging plant extract composition and preparation and application thereof |
| CN113576970B (en) * | 2021-08-09 | 2023-01-31 | 科丝美诗(中国)化妆品有限公司 | Anti-aging plant extract composition and preparation and application thereof |
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