CN1739626A - Tea extract dripping pill - Google Patents
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- CN1739626A CN1739626A CN 200510044584 CN200510044584A CN1739626A CN 1739626 A CN1739626 A CN 1739626A CN 200510044584 CN200510044584 CN 200510044584 CN 200510044584 A CN200510044584 A CN 200510044584A CN 1739626 A CN1739626 A CN 1739626A
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Abstract
The present invention provides one kind of solid dripping pill including eat extract and other components, and the dripping pill has high absorption rate and great absorption amount to raise the bioavailability of beneficial components in tea, such as tea polyphenol. The other components may be plant extracts, vitamins, ion type mineral and other matter beneficial to health. The present invention may be taken through eating or holding in mouth and may be also added into other liquid beverage, such as milk.
Description
Technical field
The present invention relates to a kind of solid tea dropping pill formulation, it can improve the bioavailability of tea extract, promptly increases in the tea beneficiating ingredient and enters the blood of human body circulation from gastrointestinal absorption.
Background technology
Folium Camelliae sinensis is the traditional large exported product of China, but mixes with the increasing of foreign market, various countries' weather conditions complicated, the severization that various countries require, the sharp increase of logistics capacity, the quickening of modern life rhythm and the multiformity of consumption, very big variation has taken place to the demand of tea in the consumption market.Mainly show: easily go mouldy when 1, Folium Camelliae sinensis is deposited under wet weather, oxidation causes content to reduce with the prolongation of resting period for the tea polyphenols of useful health, catechin, nutgall catechin etc. in the Folium Camelliae sinensis, tea flavour weakens or loses, and Folium Camelliae sinensis is stored easy generation problem.It is bigger to take volume when 2, Folium Camelliae sinensis transports, and along with the sharp increase of commodity logistics capacity, the Folium Camelliae sinensis transportation exists the big problem of volume.3, national governments are in order to protect the rights and interests of consumer; Folium Camelliae sinensis has been proposed strict more requirement; for example the content requirement to beneficiating ingredients such as the tea polyphenols in the Folium Camelliae sinensis, catechin, caffeine, nutgall catechins must reach or be higher than certain level, and harmful substance such as content of beary metal etc. all must be lower than certain level.Many finished teas do not reach these requirements, and especially to exceed standard be puzzled tea merchant and tea grower's a subject matter to content of beary metal.4, modern life rhythm is accelerated, and consumer wishes can save makes tea the time, can be anhydrous or have only under the condition of cold water and can use tea, and the problem of inconvenience is drunk in traditional Folium Camelliae sinensis existence.5, modern science is goed deep into gradually to the research of tea, finds that Folium Camelliae sinensis contains multiple composition.Wherein caffeine can play the effect of refreshing oneself by stimulating central nervous system, can suppress renal tubules and heavily absorb and have diuresis; The lax bronchial smooth muscle of theophylline can improve symptoms of asthma; Catechin in the tea polyphenols has antioxidation, defying age, prevents lipid oxidation, blood sugar lowering, blood fat reducing, microcirculation improvement are prevented and treated coronary heart disease, anti-inflammation, the irritated effect of antiallergic action control; The effect of nutgall catechin gallo catechin ester mutation antitumor and prevention and curing cancer.Because different compositions has different physiological actions, the different consumers purpose that reaches of expectation of drinking tea is also different, but multiple composition and depositing in the tea that traditional Folium Camelliae sinensis bubbles out can not meet the different needs, even produce unwanted result.For example easily the old man of insomnia wishes by having tea blood fat reducing and prevention coronary heart disease, but the caffeine in the Folium Camelliae sinensis can make insomnia increase the weight of.Traditional tea exists the problem of the individual demand that can not satisfy consumer.6, the bioavailability of traditional tea is low, though the tea element of useful human body such as tea polyphenols etc. enter gastrointestinal tract, absorbs and to enter less in the blood of human body.7, except Folium Camelliae sinensis, nature also has many natural products such as natural drug, vegetable, fruit and mineral to the human body beneficial, suitably replenishes these materials and can make human body more healthy, and premunition strengthens, and quality of the life is better.Said extracted thing and Folium Camelliae sinensis extract are cooperated, take the effect of the anti-treating diseases and making health-care that can reach expection with suitable dosage.But traditional Folium Camelliae sinensis exists defective in this respect.
At present existing different technology attempts to address the above problem.
One class be solved carry, the problem of taking convenience.Disclosed Chinese patent solid-tea buccal tablet and preparation method thereof (ZL02135175.9) for example, with it is that this class patent of representative is that Folium Camelliae sinensis is pulverized the solid preparation of making, do not consider to remove a part of heavy metal, also do not consider to adjust the content and the ratio of each beneficial element in the Folium Camelliae sinensis, also do not consider the problem of bioavailability.
One class be solved carry, taking convenience and remove the problem of a part of heavy metal.This class patent mainly is to have taked the extraction way, and as disclosed Chinese patent tea element solid buccal tablet and preparation method thereof (ZL200310115533.6), but this class patented technology is not considered the problem of bioavailability yet.
Be ZL00809620.1 effervescent green tea extract formulation (hereinafter quoting) about the publication document that improves the tea alkaloid availability at present with effervescent.
Effervescent mainly is to produce foam with medicinal acid when mixing with solution by carbonate, and this product too busy to get away solution when taking unfortunately promptly can not containing or dry-eating, exists the problem of taking inconvenience.
Effervescent mainly is to produce foam by carbonate with medicinal acid when mixing with solution, the amount of medicinal acid must be bigger than the amount of carbonate, after producing foam, still can some medicinal acid stay in the solution, enter digestive tract by drinking, may have influence on gastral acid-base balance, especially, may have a negative impact those dyspeptic people.
Effervescent mainly is to produce foam by carbonate with medicinal acid when mixing with solution, as gas, carbon dioxide in the foam solution of can overflowing, unfortunately salt ion is still stayed in the solution, and drunk in the body, can increase burden, the especially infull people of those renal functions that human body is discharged, know all that as general knowledge hypertension and kidney patient must eat salt less, these unnecessary salt ions may produce kidney damage.
Be unable to do without solution when dropping pill formulation can avoid effervescent to take, may influence the digestive tract acid-base balance and produce the problem of kidney damage, solve the conventional tea transportation again, stored, taken inconvenience, heavy metals exceeding standard, the content that can not adjust beneficiating ingredient is to satisfy different consumer needs' problem.As solid dispersion, drop pill it is believed that and can improve bioavailability, and generally speaking, dropping pill formulation can double than the bioavailability of conventional tablet, and the dose that promptly reduces half still has same effect.
As mentioned above, contain the natural medicine product that concentrates tea extract, can satisfy different consumer demands, its bioavailability is also high.Further saying, is to remove part heavy metal in the Folium Camelliae sinensis by extraction, adds the functional component of other useful health, utilizes solid dispersion technology to increase the absorbance of above-mentioned substance, thereby reaches the purpose that improves bioavailability.
Summary of the invention
The purpose of this invention is to provide the natural medicine product that contains spissated tea extract, it can be chewed or containing mode is taken in the solid mode, also can be water-soluble or other polar solvent take with liquid form.
Another object of the present invention provides the natural medicine product that contains spissated tea extract, and it can increase absorbance, improves bioavailability.
The purpose that a kind of solid dispersed formulation can not set forth the above-mentioned purpose Buddhist monk comes true, and contains the tea extract that accounts for weight 10-50% in the said preparation.According to the present invention, the tea polyphenols in the tea extract comprises epigallocatechin gallate (EGCG).Other extract, for example from natural drug, that extracts from fruits and vegetables can additionally add, and in general the natural drug extract can account for the 5-30% of weight, and extract can account for the 10-50% of weight in the fruits and vegetables.Yet the weight of total tea extract and other natural materials extract can not surpass 60% of gross weight, and this is in order to add following composition with suitable weight.
In addition, contain the water-soluble base of the 30-80% that accounts for weight in the said preparation, especially Polyethylene Glycol and account for the surfactant of the 0.05-1% of weight is good with tween.In addition, the sweeting agent that said preparation also comprises the 0.1-3% that accounts for weight is sugar for example, protein sugar, stevioside, glucide or any other natural sweetener and account for flavouring agent for example jasmin essence or other the natural flavours of the 0.01-3% of weight.
The most frequently used method of the present invention is with the abundant consolute of the composition of above-mentioned specific quantity together, drips then and makes drop pill.
The other purpose and the good effect of this invention will be set forth in the explanation hereinafter, and some part is conspicuous, and perhaps part is that practice confirms and still do not have an experiment confirm.
The specific embodiment
Principle for a better understanding of the present invention now will be referred to some specific vocabulary of specializing and is explained that these specific vocabulary will repeat.However, be not circumscribed to the scope that relates to of the present invention.Any change of the product that this paper exemplifies and further correction, and any additional application of illustrational invention principle, all relate to the technology of association area and, all be considered as included in the scope involved in the present invention the ownership of these open materials.
In order to explain principle of the present invention and its application best, we will do one to some concrete conditions and set forth.Following description can make the present technique field other people under various situation, use the present invention, with various correction to deacclimatize the different application of expection.
When the concentrated extract of Folium Camelliae sinensis in the preparation was made drop pill with the solid dispersion form, the applicant found that beneficial effect and effect greatly increase in the Folium Camelliae sinensis, and the required dosage that accomplishes the end in view greatly reduces.In addition, accelerate because absorb in the body, so the bioavailability of preparation also significantly improves.
Because solid dispersion technology makes the tea extract homodisperse, more because the interpolation of surfactant makes preparation have the hydrophilic and oleophilic double properties, can see through the digestive tract biomembrane better and enter blood, make to absorb more and improve.
Because solid in transportation, store, the packing kimonos time spent is convenient, and increased the stability of extract, their speed of decomposition and inefficacy of having slowed down, this stability to processing, sell, store of crucial importance.
At first, on producing,, adopts different extracting method,, for example contain decaffeinated etc. in the extract to determine the content of various heterogeneities in the extract according to different effect demands.It is the method that has been widely known by the people that water and Different concentrations of alcohol are extracted.In order to extract some specific effective ingredient, also can adopt some specific extractive techniques, for example use ethyl acetate extraction.Secondly, the spray drying powder of extract and water-soluble base such as molecular weight are 4000 Polyethylene Glycol and surfactant such as Tween 80,80-120 ℃ of down molten molten mixing and stirring.Though Macrogol 4000 is first-selected water-soluble base, water-soluble base that other is common such as molecular weight Polyethylene Glycol, glycerin gelatine, sodium stearate, polyoxyethylene monostearate, polyethers and their mixture between 200 to 9000 also all is adapted at using in the said preparation.In addition, although Tween 80 is first-selected surfactant, many in correlation technique known surfactant also can use equally, such surfactant comprises but is not limited to: arabic gum, hydroxymethyl cellulose sodium, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium laurylsulfate, polysorbas20, polysorbate40, polysorbate60, Tween 80, polysorbate85, rare 400 monolaurates of polyoxy second, rare 400 monostearates of polyoxy second, the rare stearate of polyoxy second, rare 40 stearates of polyoxy second, the rare octyl phenyl ether of polyoxy second, the rare hexadecanol ether of polyoxy second, the rare lauryl alcohol of polyoxy second, poly-methyl-prop diluted acid ester, molecular weight is polyvinylpyrrolidone between the 2500-3000000 and their mixture.
Except composition above-mentioned, can add for example sugar of sweeting agent based on the needs of taste, protein sugar, stevioside, glucide or any other natural sweetener and flavouring agent for example jasmin essence or other natural flavours.
In case needed all the components is behind molten molten mixing, the dosage of preparation is to decide according to the production technology of the drop pill of technical field routine.
During use, from fractional pack, take out preparation, put in the mouth and chew or containing, or put water or other solution as required into such as drinking in the fruit juice.
The present invention mainly concentrates on the production of the dropping pill formulation that contains the extract that concentrates tea.In addition, the extract with certain natural drug useful, medical function, fruits and vegetables etc. all can be used.
Tea formulation or mixture comprise but not only are confined among concrete the present invention: in the classifications such as the green tea in the Chinese tea, black tea, postfermented tea, oolong tea, Ramulus et Folium Mussaendae Pubescentis, yellow tea as Dragon Well tea, Biluochun, sunshine green grass or young crops, Radix Rhamni Heterophyllae, Pu'er, keemun, Yunnan red tea, Hunan postfermented tea, West Road, Sichuan brick tea, South Road brick tea, white peony, Silver-needle Pekoe, tribute eyebrow, Shou Mei, Junshan Silver Needle Tea.Japan's tea such as Sencha, Kukicha, Genmacha, Macha.India tea such as Makaibari estate, Assam, Darjeeling, Nilgiri and Orissa etc.The tea that other can be used, but specifically do not mentioned and can be able to same utilization because of specific composition good for health.
Except the selected plant extract beyond the region of objective existence that can be used as tea, still can add wholesome composition, as water capacity vitamin or fatsoluble vitamin.In this patent, water soluble vitamins comprises but not only is confined to vitamin B1, B2, B3, B5, B6, B12, B13, B15, B17, biotin, choline, folic acid, inositol, para-amino benzoic acid, vitamin C and Citrin or their mixture.In addition, fatsoluble vitamin comprises but not only is confined to vitamin A, D, E, K or their mixture.
Except that above-mentioned substance, this patent also includes aminoacid, the mineral ion and the Natural antioxidant.Aminoacid includes but not limited to: glycine, serine, aspartic acid, leucine, lysine, tyrosine, alanine, arginine, histidine, methionine, ornithine, phenylalanine, valine, carnitine, γ-An Jidingsuan, glycine, taurine, N-ethyl cystein or their mixture.In addition, ion mineral matter comprises cation and anion.At last, the Natural antioxidant includes but are not limited to beta-carotene, seed of Fructus Vitis viniferae flavone, coenzyme Q10 and their mixture in this patent.
Among the present invention, the plant extract that can make the tea drop pill is a lot, in order more to be expressly understood this patent, to explain some nouns below: the tea plant comprises that the strain of all Camellia plants is a crossbred extremely, and be grown in all over the world the relevant with it plant that can pick tea-leaves, comprise their mixture or crossbred.In addition, also comprise this class strain system is reached relevant various mixture, the processing of compositions different modes, as half fermentation, fermentation or excessive fermentation etc.Also have, the natural drug of mentioning in this patent comprises the medical material of botanical, animality medical material and microorganisms, and they comprise flower, fruit, seed, peel, leaves, root, root bark, the bark of plant; The skin of animal, bone, internal organs, angle, meat, fat; The metabolites of microorganism etc. have the part of health care and therapeutical effect to human body.
The present invention is further illustrated below in conjunction with embodiment, and the amount of every kind of composition among the embodiment and each component composition only are representational, but not are limitations of the present invention.
Embodiment one
Become to be grouped into (%, W/W)
*Tea extract 10-50
Macrogol 4000 30-80
Tween 80 0.05-1
Sweeting agent 0.1-5
Flavouring agent 0.01-3
*Tea extract can contain caffeine, or decaffeinated.Tea can ferment, and half is that ferment or full fermentation.
Embodiment two
Become to be grouped into (%, W/W)
Tea extract 10-50
*Vitamin 1-10
Macrogol 4000 30-80
Tween 80 0.05-1
Sweeting agent 0.1-5
Flavouring agent 0.01-3
*Can contain one or more water soluble vitamins, as vitamin B1, B2, B3, B5, B6, B12, B13, B15, B17, biotin, choline, folic acid, inositol, para-amino benzoic acid, vitamin C and Citrin or vitamin A, D, E, K or their mixture.
Embodiment three
Become to be grouped into (%, W/W)
Tea extract 10-50
*Amino acid/11-10
Macrogol 4000 30-80
Tween 80 0.05-1
Sweeting agent 0.1-5
Flavouring agent 0.01-3
*Aminoacid can for but be not limited to glycine, serine, aspartic acid, leucine, lysine, tyrosine, alanine, arginine, histidine, methionine, ornithine, phenylalanine, valine, carnitine, γ-An Jidingsuan, glycine, taurine, N-ethyl cystein or their mixture.
Embodiment four
Become to be grouped into (%, W/W)
Tea extract 10-50
*Ion mineral matter 1-10
Macrogol 4000 30-80
Tween 80 0.05-1
Sweeting agent 0.1-5
Flavouring agent 0.01-3
*Ion mineral matter is natural cation and anion.
Embodiment five
Become to be grouped into (%, W/W)
Tea extract 10-50
*Natural drug extract 5-30
Macrogol 4000 30-80
Tween 80 0.05-1
Sweeting agent 0.1-5
Flavouring agent 0.01-3
*Natural drug extract source is wider, the effect of its preparation is also different different because of the effect of raw material disease preventing and treating, as prevents and treats influenza, antithrombotic, arteriosclerosis, adjusting gastrointestinal tract, improves sleep, improves immunity, adjust blood pressure, blood sugar lowering, blood fat reducing, loses weight, adjusts endocrine or the like.These natural drug extracts can derive from but be not limited only to following: Radix Ginseng, Radix Notoginseng, Folium Isatidis, mountain Zhu's cornel, Fructus Ligustri Lucidi, Radix Asparagi, Rhizoma Gastrodiae, Fructus Schisandrae Chinensis, Flos Rosae Chinensis, Radix Salviae Miltiorrhizae, Radix Ilicis Pubescentis, Hirudo, Rhizoma Polygonati Odorati, Rhizoma Corydalis, Radix Glycyrrhizae, Folium Pyrrosiae, Herba Dendrobii, Radix Glehniae, Rhizoma Curculiginis, Cordyceps, Rabdosia rubescens, Fructus Trichosanthis, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Semen Lablab Album, Radix Scrophulariae, Pheretima, Cortex Lycii, the Fructus Kochiae, Radix Rehmanniae, Radix Sanguisorbae, Bulbus Lilii, the Radix Stemonae, Stigma Croci, west sheep ginseng, Radix Angelicae Sinensis, Cortex Albiziae, Flos Carthami, Radix Rhodiolae, Aloe, Radix Paeoniae Rubra, Fructus Forsythiae, Radix Ophiopogonis, Fructus Hordei Germinatus, Radix Polygoni Multiflori, Ganoderma, Radix Et Caulis Acanthopanacis Senticosi, Flos Rosae Rugosae, Radix Codonopsis, Flos Trollii, Flos Lonicerae, the Herba Lycopi, Radix Adenophorae (Radix Glehniae), Fructus Aurantii Immaturus, Fructus Lycii, Margarita, Poria, Semen Sterculiae Lychnophorae, Folium Nelumbinis, Semen Nelumbinis, Herba Leonuri, Flos Mume, Flos Chrysanthemi, Rhizoma Polygonati, Flos Buddlejae, Herba Epimedii, Stigma Croci, Semen Ziziphi Spinosae, Herba Menthae, Pollen Typhae, Herba Taraxaci, Radix Puerariae, Flos Sophorae, Folium Ginkgo, Fructus Hippophae, Herba Hyperici perforati, gin and their mixture.
Embodiment six
Become to be grouped into (%, W/W)
Tea extract 10-50
*Natural antioxidant 1-10
Macrogol 4000 30-80
Tween 80 0.05-1
Sweeting agent 0.1-5
Flavouring agent 0.01-3
*Antioxidant can derive from but be not limited only to following: beta-carotene, seed of Fructus Vitis viniferae flavone, coenzyme Q10 and their mixture.
Embodiment seven
Become to be grouped into (%, W/W)
Tea extract 10-50
*Fruits extract 10-50
Macrogol 4000 30-80
Tween 80 0.05-1
Sweeting agent 0.1-5
Flavouring agent 0.01-3
*The fruits extract can derive from but be not limited only to following: Fructus Fici, Fructus Momordicae, Fructus Mangifera Indicae, Fructus Mali pumilae, Fructus Musae, Fructus Ananadis comosi, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Pruni, Pericarpium Citri tangerinae, Fructus Crataegi, Fructus Citri grandis, Fructus actinidiae chinensis, Fructus Citri Limoniae, pears, Fructus Citri tangerinae, Fructus Chaenomelis, peach, Fructus Pruni salicinae, Punica granatum L., Fructus Fragariae Ananssae, Citrullus vulgaris and their mixture.
Embodiment eight
Become to be grouped into (%, W/W)
Tea extract 10-50
*Greengrocery extract 10-50
Macrogol 4000 30-80
Tween 80 0.05-1
Sweeting agent 0.1-5
Flavouring agent 0.01-3
*The greengrocery extract can derive from but be not limited only to following: Fructus Lycopersici esculenti, Cucurbita pepo L., Lentinus Edodes, Volvariella volvacea (Bull.Ex Franch.) Singer, JINZHENGU, Hericium erinaceus (Bull. Ex Fr.) Pers., Herba Apii graveolentis, Herba Spinaciae, Broccoli, Brassica oleracea L. var. botrytis L., Herba Fimbristylis dichotomae, Plantula Brassicae chinensis, Chinese cabbage, Brassica campestris L, Chenopodium album, three-coloured amaranth, bamboo sprout, Germinatus Phragmitis, Kidney bean, Semen Phaseoli Vulgaris, Semen Pisi sativi, Rhizoma Solani tuber osi, Radix Raphani, Radix Dauci Sativae, Herba Alii fistulosi, Herba Alii fistulosi, Bulbus Allii Cepae, Fructus Cucurbitae moschatae, Fructus Cucumidis sativi, Fructus Luffae, Fructus Sechii edulis, green pepper, Fructus Solani melongenae, Caulis et Folium Lactucae sativae and their mixture.
More than detailed application of the present invention described, under the prerequisite of aim of the present invention and scope, may some modification on some ins and outs, the additional claim in back will contain some modifications.These modifications may be for example size, medicament categories, raw material, shape, the mechanism of action and mode, production and use etc.
Claims (22)
1. a tea extract dripping pill is water-soluble solid preparation, and its weight is composed as follows:
A) 10-50% through spissated tea extract, wherein tea extract contains the tea polyphenols of the 5-99% that accounts for weight;
B) water-soluble base of 30-80%;
C) surfactant of 0.05-1%;
D) sweeting agent of 0.1-3%;
E) flavouring agent of 0.01-3%.
2. tea extract dripping pill according to claim 1, wherein tea extract is unleavened.
3. tea extract dripping pill according to claim 1, wherein tea extract is by fermentation.
4. tea extract dripping pill according to claim 1, wherein tea extract is decaffeinated.
5. tea extract dripping pill according to claim 1, wherein tea extract contains caffeine.
6. tea extract dripping pill according to claim 1, wherein the tea polyphenols in the tea extract comprises epigallocatechin gallate (EGCG).
7. according to the described tea extract dripping pill of claim 1-6, wherein said water-soluble base is selected from following: Polyethylene Glycol, glycerin gelatine, sodium stearate, polyoxyethylene monostearate, polyethers and their mixture of molecular weight between 200 to 9000.
8. according to the described tea extract dripping pill of claim 1-6, wherein said surfactant is selected from following: arabic gum, hydroxymethyl cellulose sodium, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium laurylsulfate, polysorbas20, polysorbate40, polysorbate60, Tween 80, polysorbate85, rare 400 monolaurates of polyoxy second, rare 400 monostearates of polyoxy second, the rare stearate of polyoxy second, rare 40 stearates of polyoxy second, the rare octyl phenyl ether of polyoxy second, the rare hexadecanol ether of polyoxy second, the rare lauryl alcohol of polyoxy second, poly-methyl-prop diluted acid ester, molecular weight is polyvinylpyrrolidone between the 2500-3000000 and their mixture.
9. according to the described tea extract dripping pill of claim 1-6, wherein also contain the sweeting agent of 0.1-3%.
10. according to the described tea extract dripping pill of claim 1-6, wherein also contain the flavouring agent of 0.01-3%.
11. according to the described tea extract dripping pill of claim 1-6, wherein also contain one of following ingredients at least: vitamin, aminoacid, ion mineral matter, the Natural antioxidant and their mixture, wherein the percentage by weight of each composition is between 1-10%.
12. tea extract dripping pill according to claim 11, wherein said vitamin is a kind of water soluble vitamins, is selected from following: vitamin B1, B2, B3, B5, B6, B12, B13, B15, B17, biotin, choline, folic acid, inositol, para-amino benzoic acid, vitamin C and Citrin or their mixture.
13. tea extract dripping pill according to claim 11, wherein said vitamin is a kind of fatsoluble vitamin, is selected from following: vitamin A, D, E, K or their mixture.
14. tea extract dripping pill according to claim 11, wherein said aminoacid is selected from following: glycine, serine, aspartic acid, leucine, lysine, tyrosine, alanine, arginine, histidine, methionine, ornithine, phenylalanine, valine, carnitine, γ-An Jidingsuan, glycine, taurine, N-ethyl cystein or their mixture.
15. tea extract dripping pill according to claim 11, wherein said ion mineral matter is a kind of cation.
16. tea extract dripping pill according to claim 11, the wherein said Natural antioxidant is selected from following: beta-carotene, seed of Fructus Vitis viniferae flavone, coenzyme Q10 and their mixture.
17. according to the described tea extract dripping pill of claim 1-6, wherein also contain the material of from following component, choosing: natural drug extract, fruit extract, vegetable extract and their mixture, wherein the natural drug extract accounts for the 5-30% of weight, fruit extract, vegetable extract account for the 10-50% of weight, said extracted thing and tea extract weight sum be no more than preparation gross weight 60%.
18. tea extract dripping pill according to claim 17, wherein said crude drug extract is selected from following: Radix Ginseng, Radix Notoginseng, Folium Isatidis, mountain Zhu's cornel, Fructus Ligustri Lucidi, Radix Asparagi, Rhizoma Gastrodiae, Fructus Schisandrae Chinensis, Flos Rosae Chinensis, Radix Salviae Miltiorrhizae, Radix Ilicis Pubescentis, Hirudo, Rhizoma Polygonati Odorati, Rhizoma Corydalis, Radix Glycyrrhizae, Folium Pyrrosiae, Herba Dendrobii, Radix Glehniae, Rhizoma Curculiginis, Cordyceps, Rabdosia rubescens, Fructus Trichosanthis, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Semen Lablab Album, Radix Scrophulariae, Pheretima, Cortex Lycii, the Fructus Kochiae, Radix Rehmanniae, Radix Sanguisorbae, Bulbus Lilii, the Radix Stemonae, Stigma Croci, west sheep ginseng, Radix Angelicae Sinensis, Cortex Albiziae, Flos Carthami, Radix Rhodiolae, Aloe, Radix Paeoniae Rubra, Fructus Forsythiae, Radix Ophiopogonis, Fructus Hordei Germinatus, Radix Polygoni Multiflori, Ganoderma, Radix Et Caulis Acanthopanacis Senticosi, Flos Rosae Rugosae, Radix Codonopsis, Flos Trollii, Flos Lonicerae, the Herba Lycopi, Radix Adenophorae (Radix Glehniae), Fructus Aurantii Immaturus, Fructus Lycii, Margarita, Poria, Semen Sterculiae Lychnophorae, Folium Nelumbinis, Semen Nelumbinis, Herba Leonuri, Flos Mume, Flos Chrysanthemi, Rhizoma Polygonati, Flos Buddlejae, Herba Epimedii, Stigma Croci, Semen Ziziphi Spinosae, Herba Menthae, Pollen Typhae, Herba Taraxaci, Radix Puerariae, Flos Sophorae, Folium Ginkgo, Fructus Hippophae, Herba Hyperici perforati, gin and their mixture.
19. tea extract dripping pill according to claim 17, wherein said fruit extract is selected from following: Fructus Fici, Fructus Momordicae, Fructus Mangifera Indicae, Fructus Mali pumilae, Fructus Musae, Fructus Ananadis comosi, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Pruni, Pericarpium Citri tangerinae, Fructus Crataegi, Fructus Citri grandis, Fructus actinidiae chinensis, Fructus Citri Limoniae, pears, Fructus Citri tangerinae, Fructus Chaenomelis, peach, Fructus Pruni salicinae, Punica granatum L., Fructus Fragariae Ananssae, Citrullus vulgaris and their mixture.
20. tea extract dripping pill according to claim 17, wherein said vegetable extract is selected from following: Fructus Lycopersici esculenti, Cucurbita pepo L., Lentinus Edodes, Volvariella volvacea (Bull.Ex Franch.) Singer, JINZHENGU, Hericium erinaceus (Bull. Ex Fr.) Pers., Herba Apii graveolentis, Herba Spinaciae, Broccoli, Brassica oleracea L. var. botrytis L., Herba Fimbristylis dichotomae, Plantula Brassicae chinensis, Chinese cabbage, Brassica campestris L, Chenopodium album, three-coloured amaranth, bamboo sprout, Germinatus Phragmitis, Kidney bean, Semen Phaseoli Vulgaris, Semen Pisi sativi, Rhizoma Solani tuber osi, Radix Raphani, Radix Dauci Sativae, Herba Alii fistulosi, Herba Alii fistulosi, Bulbus Allii Cepae, Fructus Cucurbitae moschatae, Fructus Cucumidis sativi, Fructus Luffae, Fructus Sechii edulis, green pepper, Fructus Solani melongenae, Caulis et Folium Lactucae sativae and their mixture.
21. according to the described tea extract dripping pill of claim 1-6, wherein said preparation is a drop pill.
22. a method of producing tea extract dripping pill may further comprise the steps:
A) preparation is according to the composition described in one of claim 1-20;
B) mix said composition:
C) the said composition of processing is to drop pill.
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