CN101584803B - Medicament for improving immunizing power and preparing method thereof - Google Patents
Medicament for improving immunizing power and preparing method thereof Download PDFInfo
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- CN101584803B CN101584803B CN2008100980150A CN200810098015A CN101584803B CN 101584803 B CN101584803 B CN 101584803B CN 2008100980150 A CN2008100980150 A CN 2008100980150A CN 200810098015 A CN200810098015 A CN 200810098015A CN 101584803 B CN101584803 B CN 101584803B
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Abstract
The invention discloses medicament for improving immunizing power and a preparing method thereof. Radix pseudostellariae, atractylis ovata, cortex lycii radicis, ophiopogon roots, ganoderma and lepidium seeds are used as raw materials, the raw materials are divided into A group and B group, the raw materials of the A group is extracted by ethanol and is purified by being absorbed by macroporous resin, the water extract of the B group is precipitated by adding the ethanol, and the medicament is obtained by drying the mixture of the obtained extract of the A group and the filter cake of the B group. The invention is the extract of natural plants, can improve the resistance against diseases and the immunizing power of animals and can promote the growth of the animals with obvious effect. The invention can replace antibiotics, and has the advantages of no medicine hangover and no toxic side effect.
Description
Technical field
The present invention relates to a kind ofly can improve medicine of immunity and preparation method thereof.
Background technology
In feedstuff, use the sick measure that must take as aquaculture of antibiotic prophylaxis animal, antibiotic life-time service in the animal feed, cause animal lower for the resistance, the drug resistance that reaches pathogenic microorganism in the environment simultaneously in the animal body is more and more stronger, and antibiotic reduces gradually to the disease-resistant of poultry and growth promotion effect.Antibiotic constitutes greatly threat by food chain to human health simultaneously.
Chinese medicine can be prevented and cured diseases, and improves animal immunizing power, and can promote the growth of animal.It is little that while Chinese medicine has toxic and side effects, is difficult for producing in edible livestock products such as meat egg the characteristics of hazard residue.
The common Chinese additive is that Chinese medicine is added in the feedstuff then through simple processing, and additive capacity is big, influence palatability, because processing simply, bioavailability is low, can not give full play to the function of Chinese medicine.
Summary of the invention
The object of the present invention is to provide a kind of bioavailability height, absorb fully, alternative antibiotic improves premunition and the immunity of animal, promotes the growth of animal, and life-time service drug residue free, a kind of medicine of having no side effect and preparation method thereof.
A kind of characteristics that improve the medicine of immunity are that its raw material by weight consists of:
Radix Pseudostellariae 30-50 part, Rhizoma Atractylodis Macrocephalae 20-30 part, Cortex Lycii 20-30 part, Radix Ophiopogonis 20-30 part, Ganoderma 4-12 part, Semen Lepidii (Semen Descurainiae) 6-16 part.
The optimum weight proportioning of medicine of the present invention is:
40 parts of Radix Pseudostellariaes, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 25 parts of Cortex Lycii, 25 parts of Radix Ophiopogonis, 8 parts of Ganodermas, 11 parts of Semen Lepidii (Semen Descurainiae)s.
According to the medicine of above-mentioned raising immunity, it is characterized in that said medicament is a said dosage form on any pharmaceutics.
According to the medicine of described raising immunity, it is characterized in that said medicament is powder, tablet, granule, capsule, drop pill.
Feature according to the preparation method of the medicine of described raising immunity is to operate as follows:
A, with Semen Lepidii (Semen Descurainiae), Ganoderma, removal of impurity Radix Ophiopogonis, add ethanol extraction 1-3 time, filter, get residue and filtrate, 1. filtrate recycling ethanol gets concentrated solution, make every milliliter of concentrated solution 1. be equivalent to the 2.0-5.0g crude drug, 1. concentrated solution uses the macroporous adsorbent resin separation and purification, and it is 1.0-1.1g/mL that eluent is concentrated to density, gets concentrated solution 2.;
B, with the Rhizoma Atractylodis Macrocephalae, Cortex Lycii, the Radix Pseudostellariae removal of impurity, with the residue obtained extracting in water of step a 1-3 time, filter medicinal liquid, it is 1.0-1.2g/mL that medicinal liquid is concentrated to density, adds an amount of ethanol in the concentrated solution, precipitation is filtered, and reclaims filter cake;
C, with step a gained concentrated solution 2. with step b gained filter cake combination drying, extract.
With the extract that above method obtains, pulverized 100 orders, add the microcrystalline Cellulose of 5-15%, mix homogeneously promptly gets powder.
With the extract that above method obtains, pulverized 100 orders, add microcrystalline Cellulose 5-15%, CMC-Ca 0.4-0.6%, mixing, use 70% alcohol granulation, cross 18 mesh sieves, 50-60 ℃ of drying crossed 18 mesh sieve granulate, magnesium stearate 0.5%, mixing, tabletting promptly gets tablet.
With the extract that above method obtains, pulverized 100 orders, add microcrystalline Cellulose 5-15%, mixing, use 70% alcohol granulation, cross 18 mesh sieves, 50-60 ℃ of drying crossed 18 mesh sieve granulate, promptly gets granule.
With the extract that above method obtains, pulverized 100 orders, add microcrystalline Cellulose 5-15%, mixing, use 70% alcohol granulation, cross 18 mesh sieves, 50-60 ℃ of drying crossed 18 mesh sieve granulate, and be encapsulated, promptly gets capsule.
With the extract that above method obtains, pulverized 100 orders, standby, place 90-100 ℃ water-bath to be heated to fusion PEG6000, add 100 order dried cream powders, make medicine account for the 15-30% of gross weight.Mix homogeneously at 75-85 ℃, splashes into temperature maintenance in the liquid paraffin with mixture, and drying promptly gets drop pill.
1, extract drugs method research
According to the physical property of main effective ingredient in the prescription, the method for having taked alcohol extraction and water to carry respectively.And adopt orthogonal test that the kind and the optimal adsorption condition of macroporous resin are studied to the alcohol extraction component.Through three batches of pilot scale checkings, prove that this technology is reasonable, favorable reproducibility gears to actual circumstances.The pilot scale data see Table 1.
Table 1 extract drugs pilot scale data
2, clinical trial and clinical verification
A, test drug and test pig
1. medicine
Powder of the present invention, enrofloxacin, gentamycin, LIJUNJING injection and powder.
2. participate in the experiment pig and grouping
2.1 suckling pig has been chosen " three dysentery " medical history, parity, the breeding age in days approaching, 36 pigs that farrow of multiparity sow that same position poultry raiser raises, with the primitive pit is that unit is divided into 3 groups at random, powder group promptly of the present invention (hereinafter to be referred as 1 group of suckling), conventional antimicrobial drug group (hereinafter to be referred as 2 groups of sucklings), blank group (hereinafter to be referred as 3 groups of sucklings).
2.2 ablactational baby pig is selected certain pig farm sow breeding, accepted routine immunization, kind is identical, be in a good state of health, the body weight gap is less, raising condition, basal diet, feed method, the place sterilization is all identical, finds no 228 in 28 age in days ablactational baby pig, 24 nests of symptom of diarrhea during wean, with the primitive pit is that unit is divided into 3 groups at random, powder group promptly of the present invention (hereinafter to be referred as 1 group of wean), conventional antimicrobial drug group (calling 2 groups of wean in the following text with letter), blank group (hereinafter to be referred as 3 groups of wean).
3. test method
3.1 1 group of suckling pig suckling, 12 sows calculate that by expected date of confinement preceding 7 days of Farrowing uses the forage feed that adds 0.1% powder of the present invention, 128 of common property piglets (2 ages in days are strong lives), not intramuscular injection of piglet any medicine also not for oral administration.2 groups of sucklings.12 of sows were calculated by expected date of confinement, gave a birth every conventional antimicrobial drug intramuscular injection of usefulness, 1 day 2 times, logotype 3 days preceding 7 days.129 of its pigs that farrows (2 ages in days are strong lives), the conventional antimicrobial drug of intramuscular injection, 1 day 2 times, for three days on end.3 groups of sucklings.12 of sows were given a birth preceding 7 days, not intramuscular injection or any antimicrobial drug for oral administration.126 of its piglets that gives birth to (2 ages in days are strong lives), not intramuscular injection of piglet any medicine also not for oral administration.
3.2 ablactational baby pig is weaned 1 group, 77 on 8 hurdles weaned the same day, used the forage feed that adds 0.1% powder of the present invention.Connect and fed 7 days.Wean 2 groups, 75 on 8 hurdles weaned the same day, replaced the conventional antimicrobial drug of intramuscular injection, and 1 day 2 times, for three days on end.In basal diet, add multiple antimicrobial drug powder, continuous 7 days simultaneously.Wean 3 groups, 76 on 8 hurdles, wean began not have intramuscular injection and any medicine for oral administration before do not present symptom of diarrhea the same day.
4 mensuration projects
4.1 suckling pig
Piglet gives birth to 2 ages in days (being on-test), and " three dysentery Sui conditions during the wean of 30 ages in days (off-test), are weighed on an empty stomach by head to observe piglet every day.Calculate " three dysentery " of each group, M ﹠ M, average individual weight.
4.2 ablactational baby pig
During the wean of piglet 28 ages in days (on-test), weigh (starting weight) on an empty stomach, in time write down a piglet diarrhea head number and a dead number by head.During 60 ages in days (off-test), weigh on an empty stomach (end is heavy) by head, and calculate and respectively organize piglet average daily gain, diarrhea rate and mortality rate.
B, result of the test
1. suckling pig result of the test
Table 2 each group " three dysentery " and survival rate
Table 3 is respectively organized 30 age in days average weights
| Group | 30 ages in days survive number/head | TBW/Kg | Average whose body weight/Kg |
| 1 group of suckling | 119 | 1084.2 | 9.1 |
| 2 groups of sucklings | 112 | 950.2 | 8.5 |
| 3 groups of sucklings | 106 | 849.1 | 8.0 |
1.1 suckling pig " three dysentery " and survive situation as known from Table 2, in the examination phase, suckling has 19 hairs to give birth to " three dysentery ", " three dysentery " rate 14.8% for 1 group.With LIJUNJING treatment 3 days, cure 10, dead 9.2 groups of sucklings have 39 hairs to give birth to " three dysentery ", " three dysentery " rate 30.2%.With LIJUNJING treatment 3 days, cure 22, dead 17.Suckling has 98 hairs to give birth to " three dysentery ", " three dysentery " rate 77.8% for 3 groups.With LIJUNJING treatment 3 days, cure 78, dead 20." three dysentery " sick sickness rate, 1 group of suckling are than 2 groups low 15.4 percentage points of sucklings, than 3 groups low 63 percentage points of sucklings.Number of weaned during 30 ages in days, suckling improves 6.15 percentage points for 2 groups than suckling respectively for 1 group, improves 8.84 percentage points for 3 groups than suckling.
1.2 average individual weight shows from table 3 during the wean of suckling pig 30 ages in days, the ablactation of suckling pig 30 ages in days, average individual weight, 1 group of 9.1Kg of suckling, 2 groups of 8.5Kg of suckling, 3 groups of 8.0Kg of suckling.1 group of suckling is than suckling 0.6Kg more than 2 groups, than suckling 1.1Kg more than 3 groups.
2. ablactational baby pig result of the test
Table 4 is respectively organized piglet diarrhea and death condition
Table 5 is respectively organized average individual weight relatively (test period is 28 days-60 days)
| Project | Wean 1 group | Wean 2 groups | Wean 3 groups |
| An on-test number (head) | 77 | 75 | 76 |
| An off-test number (head) | 77 | 68 | 63 |
| The test natural law (my god) | 32 | 32 | 32 |
| Head is starting weight (Kg) all | 11.10 | 11.22 | 11.20 |
| Head is end heavy (Kg) all | 28.22 | 26.40 | 24.19 |
| Head is daily gain (g) all | 535 | 474 | 406 |
2.1 off-test, each organizes piglet diarrhea and death condition shows that from table 4 in 32 days examination phases, weaning 1 group has 6 diarrhoea, and diarrhea rate 7.8% (6/77) does not have dead; Weaning 2 groups has 24 diarrhoea, diarrhea rate 32.0% (24/75), dead 7, mortality rate 9.3% (7/75); Wean 3 groups, suffer from diarrhoea 54, diarrhea rate 71.1% (54/76), dead 13, mortality rate 17.1% (13/76).Diarrhea rate, 2 groups of the 1 group of ratio wean of weaning, wean descend 24.2 percentage points and 63.3 percentage points respectively for 3 groups.Mortality rate, 2 groups of the 1 group of ratio wean of weaning, wean descend 9.3 percentage points and 17.1 percentage points respectively for 3 groups.
2.2 off-test, each organizes average individual weight as known from Table 5, when piglet 28 ages in days of 3 groups wean (on-test), the difference of average individual weight is also not obvious, but the average daily gain of (off-test) when raising 60 ages in days, wean 1 group than 2 groups of raisings 12.9% of wean, improve 31.8% for 3 groups than wean.
3. conclusion
Above 4 test datas, illustrate that powder of the present invention can promote suckling pig, the immune immunologic function of ablactational baby pig, the premunition of enhancing body, reduce the sickness rate of suckling pig " three dysentery ", diarrhea of weaned piglets disease, improve survival rate, can promote growth promoter again, improve speed of weight increment.
Description of drawings
Fig. 1 is the powder preparation technology flow chart that improves the immunity medicine
Fig. 2 is the tablet producing technology flow chart that improves the immunity medicine
Fig. 3 is the granule preparation technology flow chart that improves the immunity medicine
Fig. 4 is the capsule preparation technology flow chart that improves the immunity medicine
Fig. 5 is the drop pill preparation technology flow chart that improves the immunity medicine
The specific embodiment
The preparation that embodiment 1 improves the immunity drug powder:
Prescription:
40 parts of Radix Pseudostellariaes, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 25 parts of Cortex Lycii, 25 parts of Radix Ophiopogonis, 8 parts of Ganodermas, 11 parts of Semen Lepidii (Semen Descurainiae)s
Preparation method:
One, extracts
A, with Semen Lepidii (Semen Descurainiae), Ganoderma, removal of impurity Radix Ophiopogonis, adding 10 times of amounts of 80% ethanol extracted 1.5 hours, measured 1 hour for 8 times, filter, get residue and filtrate, decompression filtrate recycling ethanol, get concentrated solution 1., make milliliter concentrated solution 1. be equivalent to the 4g crude drug, 1. concentrated solution uses NKA-II type resin separation purification, it is 1.05g/mL that eluent is concentrated to density, gets concentrated solution 2.;
B, with the Rhizoma Atractylodis Macrocephalae, Cortex Lycii, the Radix Pseudostellariae removal of impurity, extracted 1.5 hours with the residue obtained 15 times of amounts of water that add of step a, 10 times the amount 1 hour, filter medicinal liquid, it is 1.1g/mL that medicinal liquid is concentrated to density, add 95% ethanol in the concentrated solution, making concentration of alcohol is 75%, stirs standing over night, filter, reclaim filter cake;
C, with step a gained concentrated solution 2. with step b gained filter cake combination drying, extract.
Two, preparation
With the microcrystalline Cellulose of said extracted thing adding 5-15%, mix homogeneously promptly gets powder.
The preparation that embodiment 2 improves the immunity medicinal tablet:
Prescription:
40 parts of Radix Pseudostellariaes, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 25 parts of Cortex Lycii, 25 parts of Radix Ophiopogonis, 8 parts of Ganodermas, 11 parts of preparation methoies of Semen Lepidii (Semen Descurainiae):
One, extracts
A, with Semen Lepidii (Semen Descurainiae), Ganoderma, removal of impurity Radix Ophiopogonis, adding 10 times of amounts of 80% ethanol extracted 1.5 hours, measured 1 hour for 8 times, filter, get residue and filtrate, decompression filtrate recycling ethanol, get concentrated solution 1., make milliliter concentrated solution 1. be equivalent to the 4g crude drug, 1. concentrated solution uses NKA-II type resin separation purification, it is 1.05g/mL that eluent is concentrated to density, gets concentrated solution 2.;
B, with the Rhizoma Atractylodis Macrocephalae, Cortex Lycii, the Radix Pseudostellariae removal of impurity, extracted 1.5 hours with the residue obtained 15 times of amounts of water that add of step a, 10 times the amount 1 hour, filter medicinal liquid, it is 1.1g/mL that medicinal liquid is concentrated to density, add 95% ethanol in the concentrated solution, making concentration of alcohol is 75%, stirs standing over night, filter, reclaim filter cake;
C, with step a gained concentrated solution 2. with step b gained filter cake combination drying, extract.
Two, preparation
The said extracted thing is added microcrystalline Cellulose 5-15%, CMC-Ca 0.5%, and mixing is used 70% alcohol granulation, crosses 18 mesh sieves, and 50-60 ℃ of drying crossed 18 mesh sieve granulate, magnesium stearate 0.5%, and mixing, tabletting promptly gets tablet.
The preparation that embodiment 3 improves the immunity medicinal granule:
Prescription:
40 parts of Radix Pseudostellariaes, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 25 parts of Cortex Lycii, 25 parts of Radix Ophiopogonis, 8 parts of Ganodermas, 11 parts of Semen Lepidii (Semen Descurainiae)s
Preparation method:
One, extracts
A, with Semen Lepidii (Semen Descurainiae), Ganoderma, removal of impurity Radix Ophiopogonis, adding 10 times of amounts of 80% ethanol extracted 1.5 hours, measured 1 hour for 8 times, filter, get residue and filtrate, decompression filtrate recycling ethanol, get concentrated solution 1., make milliliter concentrated solution 1. be equivalent to the 4g crude drug, 1. concentrated solution uses NKA-II type resin separation purification, it is 1.05g/mL that eluent is concentrated to density, gets concentrated solution 2.;
B, with the Rhizoma Atractylodis Macrocephalae, Cortex Lycii, the Radix Pseudostellariae removal of impurity, extracted 1.5 hours with the residue obtained 15 times of amounts of water that add of step a, 10 times the amount 1 hour, filter medicinal liquid, it is 1.1g/mL that medicinal liquid is concentrated to density, add 95% ethanol in the concentrated solution, making concentration of alcohol is 75%, stirs standing over night, filter, reclaim filter cake;
C, with step a gained concentrated solution 2. with step b gained filter cake combination drying, extract.
Two, preparation
The said extracted thing is added microcrystalline Cellulose 5-15%, mixing, use 70% alcohol granulation, cross 18 mesh sieves, 50-60 ℃ of drying crossed 18 mesh sieve granulate, promptly gets granule.
The preparation that embodiment 4 improves the immunity medicine capsule:
Prescription:
40 parts of Radix Pseudostellariaes, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 25 parts of Cortex Lycii, 25 parts of Radix Ophiopogonis, 8 parts of Ganodermas, 11 parts of Semen Lepidii (Semen Descurainiae)s
Preparation method:
One, extracts
A, with Semen Lepidii (Semen Descurainiae), Ganoderma, removal of impurity Radix Ophiopogonis, adding 10 times of amounts of 80% ethanol extracted 1.5 hours, measured 1 hour for 8 times, filter, get residue and filtrate, decompression filtrate recycling ethanol, get concentrated solution 1., make milliliter concentrated solution 1. be equivalent to the 4g crude drug, 1. concentrated solution uses NKA-II type resin separation purification, it is 1.05g/mL that eluent is concentrated to density, gets concentrated solution 2.;
B, with the Rhizoma Atractylodis Macrocephalae, Cortex Lycii, the Radix Pseudostellariae removal of impurity, extracted 1.5 hours with the residue obtained 15 times of amounts of water that add of step a, 10 times the amount 1 hour, filter medicinal liquid, it is 1.1g/mL that medicinal liquid is concentrated to density, add 95% ethanol in the concentrated solution, making concentration of alcohol is 75%, stirs standing over night, filter, reclaim filter cake;
C, with step a gained concentrated solution 2. with step b gained filter cake combination drying, extract.
Two, preparation
The said extracted thing is added microcrystalline Cellulose 5-15%, mixing, granulate with 70% alcohol, cross 18 mesh sieves, 50-60 ℃ of drying crossed 18 mesh sieve granulate, and be encapsulated, promptly gets capsule.
Embodiment 5 improves the preparation of immunity medicinal dropping ball agent:
Prescription:
40 parts of Radix Pseudostellariaes, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 25 parts of Cortex Lycii, 25 parts of Radix Ophiopogonis, 8 parts of Ganodermas, 11 parts of Semen Lepidii (Semen Descurainiae)s
Preparation method:
One, extracts
A, with Semen Lepidii (Semen Descurainiae), Ganoderma, removal of impurity Radix Ophiopogonis, adding 10 times of amounts of 80% ethanol extracted 1.5 hours, measured 1 hour for 8 times, filter, get residue and filtrate, decompression filtrate recycling ethanol, get concentrated solution 1., make milliliter concentrated solution 1. be equivalent to the 4g crude drug, 1. concentrated solution uses NKA-II type resin separation purification, it is 1.05g/mL that eluent is concentrated to density, gets concentrated solution 2.;
B, with the Rhizoma Atractylodis Macrocephalae, Cortex Lycii, the Radix Pseudostellariae removal of impurity, extracted 1.5 hours with the residue obtained 15 times of amounts of water that add of step a, 10 times the amount 1 hour, filter medicinal liquid, it is 1.1g/mL that medicinal liquid is concentrated to density, add 95% ethanol in the concentrated solution, making concentration of alcohol is 75%, stirs standing over night, filter, reclaim filter cake;
C, with step a gained concentrated solution 2. with step b gained filter cake combination drying, extract.
Two, preparation
Place 90-100 ℃ water-bath to be heated to fusion PEG6000, add extract, make the 15-30% that accounts for gross weight of medicine.Mix homogeneously at 75 ℃-85 ℃, splashes into temperature maintenance in the liquid paraffin with mixture, and drying promptly gets drop pill.
Claims (3)
1. medicine that reduces the sick sickness rate of diarrhea of weaned piglets, it is characterized in that it is the medicine that the following weight parts proportion raw material is made: Radix Pseudostellariae 30-50 part, Rhizoma Atractylodis Macrocephalae 20-30 part, Cortex Lycii 20-30 part, Radix Ophiopogonis 20-30 part, Ganoderma 4-12 part, Semen Lepidii (Semen Descurainiae) 6-16 part, and the preparation method characteristic of this medicine is to operate as follows: step a, with Semen Lepidii (Semen Descurainiae), Ganoderma, removal of impurity Radix Ophiopogonis, add ethanol extraction 1-3 time, filter, get residue and filtrate, filtrate recycling ethanol, get concentrated solution 1., make every milliliter of concentrated solution 1. be equivalent to the 2.0-5.0g crude drug, 1. concentrated solution uses NKA-II type resin separation purification, it is 1.0-1.1g/mL that eluent is concentrated to density, gets concentrated solution 2.; Step b, with the Rhizoma Atractylodis Macrocephalae, Cortex Lycii, the Radix Pseudostellariae removal of impurity, with the residue obtained extracting in water of step a 1-3 time, filter medicinal liquid, it is 1.0-1.2g/mL that medicinal liquid is concentrated to density, concentrated solution, add an amount of ethanol in the concentrated solution, precipitation is filtered, and reclaims filter cake; Step c, with step a gained concentrated solution 2. with step b gained filter cake combination drying, extract; Steps d, with extract obtained powder, tablet, granule, capsule, the drop pill made of step c.
2. medicine according to claim 1 is characterized in that it is that the following weight parts proportion raw material is made:
25 parts of 25 parts of Cortex Lycii of 40 parts of Rhizoma Atractylodis Macrocephalaes of Radix Pseudostellariae
11 parts of 8 parts of Semen Lepidii (Semen Descurainiae)s of 25 portions of Ganodermas Radix Ophiopogonis.
3. medicine according to claim 1, when it is characterized in that among the step b that concentrated solution added ethanol precipitation, ethanol content should account for the 70-80% of cumulative volume.
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| CN108029860A (en) * | 2017-12-29 | 2018-05-15 | 常德惠生九鼎食品有限公司 | It is a kind of for the Chinese medicine composition of farrowing sow and feed and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN1739626A (en) * | 2005-09-13 | 2006-03-01 | 孙景茂 | Tea extract dripping pill |
| CN101138616A (en) * | 2007-09-08 | 2008-03-12 | 门连社 | Prescription for treating tummy bug |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN1739626A (en) * | 2005-09-13 | 2006-03-01 | 孙景茂 | Tea extract dripping pill |
| CN101138616A (en) * | 2007-09-08 | 2008-03-12 | 门连社 | Prescription for treating tummy bug |
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