CN103394053B - Traditional Chinese medicine composition capable of preventing and treating piglet yellow and white scours as well as preparation and applications thereof - Google Patents

Traditional Chinese medicine composition capable of preventing and treating piglet yellow and white scours as well as preparation and applications thereof Download PDF

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CN103394053B
CN103394053B CN201310301888.8A CN201310301888A CN103394053B CN 103394053 B CN103394053 B CN 103394053B CN 201310301888 A CN201310301888 A CN 201310301888A CN 103394053 B CN103394053 B CN 103394053B
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parts
chinese medicine
hakuri
medicine composition
piglet
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CN201310301888.8A
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CN103394053A (en
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李锦宇
罗超应
谢家声
韩霞
王贵波
郑继方
罗永江
辛蕊华
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中国农业科学院兰州畜牧与兽药研究所
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Abstract

The invention discloses a traditional Chinese medicine composition capable of preventing and treating piglet yellow and white scours. The traditional Chinese medicine composition is prepared from the following active ingredients in parts by weight: 200+/-20 parts of agastache rugosa, 180+/-10 parts of radix codonopsis, 100+/-10 parts of bighead atractylodes rhizome, 100+/-10 parts of herba portulacae, 100+/-10 parts of rhizoma pinelliae, 100+/-10 parts of poria cocos, 100+/-10 parts of fructus mume, 60+/-5 parts of fresh ginger, and 60+/- 5 parts of radix glycyrrhizae preparata. The traditional Chinese medicine composition capable of preventing and treating piglet yellow and white scours has the advantages of high cure rate, small toxic and side effects, and difficultly generates drug resistance.

Description

A kind ofly prevent and treat piglet Huang, the Chinese medicine composition of Hakuri and Synthesis and applications thereof

Technical field

The present invention relates to a kind of Chinese medicine composition, relate to particularly and a kind ofly prevent and treat piglet Huang, the Chinese medicine composition of Hakuri and Synthesis and applications thereof.

Background technology

piglet is yellow, Hakuribeing the infectious disease caused by enterotoxigenic escherichia coil (ETEC), is the clinical modal infectious disease of piglet before 30 ages in days, and its sickness rate, fatality rate are high, drastically influence the development of pig industry.Often come high risks and economic loss to industrial belt of raising pigs.Wherein yellow scour of piglet often betides piglet birth afterwards within 1 week, in the majority with 1 ~ 3 age in days, and normal whole nest morbidity, sickness rate is more than 90%, and mortality rate can reach 100%.Piglet pujos blancos is multiple is born in 10 ~ 30 age in days piglets, and in the majority with 10 ~ 20 age in days persons, sickness rate can reach 30% ~ 80%.

yellow scour of piglet (yellow scour of newborn pig-lets), also known as newborn piglet colibacillosis or piglet early onset colibacillosis, be the one acute height lethal infectious intestinal disease of the nascent piglets within one week age.With diarrhoea, discharge yellow loose stool, acute death for principal character.Draw water sample loose stool, yellow or lark, include curdled milk small pieces and minute bubbles, sick pig is thirsty, eats breast and reduces, dewater, become thin, go into a coma, exhaustion.The common pathological change having enteritis and septicemia, M & M is high.

piglet pujos blancos (white scour of piglets), also known as the colibacillosis of delayed,it is a kind of acute infectious disease often occurred the piglet of 10 ~ 30 ages in days.Milky or the canescence loose stool with bad smell is rushed down for principal character with row.Piglet has loose bowels suddenly, broodly in succession occurs, row's white, canescence, smell as of rotten fish, pasty state or pulpous state feces.Piglet lassitude, fear of cold, dehydration, suck the breast and reduce or do not eat, sometimes seeing has spitting milk.The state of an illness of general sick pig is comparatively light, and treatment in time can be fully recovered, but how to form cad pig because of recurrent exerbation, and time serious, affected pig fecal incontinence, about 1 week dead.

Piglet is yellow, Hakuri is multiple is born in 10 ~ 30 age in days piglets, and within 7 ages in days, the above piglet of 30 age in days seldom falls ill.Without seasonal, winter, spring-QI wait drastic change, fall ill more during overcast and rainy, moist or warming bad and sow agalactosis.Primary disease has a strong impact on the growth promoter of piglet.Therefore, in production practices, piglet is yellow, the anti-system of Hakuri should be regarded as the most important thing of pig farm Disease Prevention work.Piglet is yellow, Hakuri mainly uses antibiotic therapy at present clinically, although antibiotic can suppress or kill many Escherichia coli, but body intestinal is except Escherichia coli, also has a large amount of non-pathogenic floras, they have very important effect to the eubolism of body, blindly use antibiotic also by suppressions or kill many non-pathogenic floras, and destroy it and form structure, have a strong impact on the digestive function of body and increase the weight of the state of an illness; Long-term a large amount of antibiotic that uses easily develops immunity to drugs in addition.Without restraint abuse chemical medicine, antibiotic and monomer medicine, both produced polynary drug resistance and the super many drug-induced disease such as quick of receptor, caused again animal products to pollute, jeopardize human food's safe and sanitary.Chinese medicine derives from animal, plant and mineral, and containing multiple biological effective components, wherein most of Chinese medicine take natural plants as raw material, aboundresources, easy acquisition, respond well, cheap, toxic and side effects is small, almost noresidue, without Drug resistance, free from environmental pollution.Therefore, it is particularly important to select that Chinese medicine preparation substitutes chemical medicine, antibiotic seems.

Summary of the invention

The technical problem to be solved in the present invention overcomes existing defect, provides that a kind of cure rate is high, toxic and side effects is little, not easily produces that the control piglet of drug resistance is yellow, the Chinese medicine composition of Hakuri.

In order to solve the problems of the technologies described above, the invention provides following technical scheme:

Prevent and treat a Chinese medicine composition for piglet Huang, Hakuri, prepared by the component of following weight portion:

Herba Pogostemonis 200 ± 20 parts; Radix Codonopsis 180 ± 10 parts; The Rhizoma Atractylodis Macrocephalae 100 ± 10 parts; Herba Portulacae 100 ± 10 parts; The Rhizoma Pinelliae 100 ± 10 parts; 100 ± 10 parts, Poria; Fructus Mume 100 ± 10 parts; 60 ± 5 parts, Rhizoma Zingiberis Recens; Radix Glycyrrhizae Preparata 60 ± 5 parts.

Preferably, prepared by the component of following weight portion:

Herba Pogostemonis 200 parts; Radix Codonopsis 180 parts; The Rhizoma Atractylodis Macrocephalae 100 parts; Herba Portulacae 100 parts; The Rhizoma Pinelliae 100 parts; 100 parts, Poria; Fructus Mume 100 parts; 60 parts, Rhizoma Zingiberis Recens; Radix Glycyrrhizae Preparata 60 parts.

Control piglet is yellow, the preparation method of the Chinese medicine composition of Hakuri, comprises the following steps:

Get each component by weight, add the water of medical material 5 times of weight, decoct 2 times, each 2 hours, collecting decoction, filtered, filtrate leaves standstill 12 hours, getting supernatant concentration to relative density is 1.20 ~ 1.30, adds ethanol to alcohol content 60%, places, filter, reclaim ethanol, adding water to relative density is 1.10 ~ 1.20, to obtain final product.

Further, add potassium sorbate 1.5 parts, be mixed, cooling 48h, filters with brown aseptic polyester bottles subpackage, and 100 DEG C of flowing steams 30 minutes, obtain oral liquid.

Control piglet is yellow, the application of the Chinese medicine composition of Hakuri in preparation control piglet Huang, Hakuri medicine.

The present invention also provides a kind of traditional Chinese medicine compound oral liquid preventing and treating piglet Huang, Hakuri, and it contains, and control piglet is yellow, the Chinese medicine composition of Hakuri and pharmaceutically acceptable adjuvant.

More than prevent and treat in the traditional Chinese medicine compound oral liquid of piglet Huang, Hakuri, described control piglet Chinese medicine composition that is yellow, Hakuri is:

Herba Pogostemonis 200 ± 20 parts; Radix Codonopsis 180 ± 10 parts; The Rhizoma Atractylodis Macrocephalae 100 ± 10 parts; Herba Portulacae 100 ± 10 parts; The Rhizoma Pinelliae 100 ± 10 parts; 100 ± 10 parts, Poria; Fructus Mume 100 ± 10 parts; 60 ± 5 parts, Rhizoma Zingiberis Recens; Radix Glycyrrhizae Preparata 60 ± 5 parts,

Or

Herba Pogostemonis 200 parts; Radix Codonopsis 180 parts; The Rhizoma Atractylodis Macrocephalae 100 parts; Herba Portulacae 100 parts; The Rhizoma Pinelliae 100 parts; 100 parts, Poria; Fructus Mume 100 parts; 60 parts, Rhizoma Zingiberis Recens; Radix Glycyrrhizae Preparata 60 parts.Described oral liquid obtains especially by following steps:

Get each component by weight, add the water of medical material 5 times of weight, decoct 2 times, each 2 hours, collecting decoction, filters, and filtrate leaves standstill 12 hours, getting supernatant concentration to relative density is 1.20 ~ 1.30, adds ethanol to alcohol content 60%, places, filter, reclaim ethanol, adding water to relative density is 1.10 ~ 1.20, add potassium sorbate 1.5 parts, be mixed, cooling 48h, filter with brown aseptic polyester bottles subpackage, 100 DEG C of flowing steams 30 minutes, to obtain final product.

the present invention has following beneficial effect:

Medicine of the present invention can directly gavage for poultry when concrete use.

Chinese veterinarian thinks that piglet is yellow, the immanent cause of the morbidity of Hakuri is piglet weakness of spleen and stomach.The flourishing blastoprolepsis of piglet life, required essence of water and grain wants many relative to Adult Pig, and taste burden is heavy.In addition piglet is easily injury due to diet, therefore easily has loose bowels.Exopathogenic factor mainly (1) experiences seasonal pathogen: experience the foul pestilential pathogen of cold-damp, or because coveting cool sleeping in the open, cold-damp is invaded, exopathogen oxious gas, strongly fragrantly hold back middle Jiao, taste all can be made injured, dysfunction of the spleen in transportation and transformation, disorder of QI movement, disorder in ascending and descending, abnormal ascent-descent between clear YANG and turbid YIN, disorderly in the intestines and stomach, drops and forms.(2) feed unclean: feed unclean, enter rotten deteriorating food of turning sour by mistake, or cold and cool feedstuff, can impairing the spleen and stomach, pure and impurely mixedly mutually form dysentery.

In sum, primary disease is mainly tender and lovely because of piglet internal organs, and shape gas does not fill or congenital malformation, undernutrition, will cause piglet weakness of the spleen and stomach and resistance to decline the day after tomorrow, the wet foul gas of impression, the heresy of cold-damp pyretic toxicity invades taste in an opponent's defence, and noxious dampness is stranded spleen, deficiency of spleen-QI and stomach-QI, hypoactivity of YANG in middle-JIAO, and it is sluggish to cause mechanism of qi, lifting is disorderly inverse, the main fortune transporting of spleen and sending up the lucid YANG, stomach receiving food and drink and the turbid descending is cloudy, in the present, void has cold, lifting dereliction of duty, therefore be lower profit stomachache, loss of appetite; The digestive and absorptive functions generation obstacle of taste, clear QI being mixed up with turbid QI mix and under, damp and hot tenesmus, intestine and small intestine is secreted and is not neglected one's duty, and water is wet a point profit can not be formed and have loose bowels, therefore excrement is rare, stench, or in malicious stagnant intestinal, intestinal QI and blood block, turn to pus white, therefore dysentery color is white or be with pus white.

Control should invigorating the spleen for eliminating dampness, stomach function regulating antidiarrheal, restrain astringent or styptic treatment for spontaneous sweating, heat-clearing and toxic substances removing.

This prescription is formed by traditional Chinese drug inspissations such as Herba Pogostemonis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Fructus Mumes, effects a permanent cure with invigorating the spleen to clear away damp pathogen, stomach function regulating removing toxic substances, restrains astringent or styptic treatment for spontaneous sweating taking stopgap measures and reaches the object for the treatment of yellow and white dysentery of piglet.

Medicine of the present invention is with the pungent temperature cold expelling of Herba Pogostemonis, and removing dampness by means of aromatics, regulating the flow of Qi and the middle Jiao, stomach function regulating pleases spleen, and double the exterior and the interior of controlling is for monarch.The sun of Rhizoma Zingiberis Recens warm the middle warmer and go out interior cold, can stopping nausea and vomiting by lowering the adverse flow of QI, makes gastric qi and suitable; Radix Codonopsis QI invigorating invigorating YANG, spleen invigorating the lucid yang sending up, coordinates Rhizoma Zingiberis, coordinates QI of the spleen and stomach lifting; Be ministerial drug altogether.Rhizoma Pinelliae dampness sending down the abnormal ascending QI, stomach function regulating preventing or arresting vomiting; Rhizoma Atractylodis Macrocephalae the spleen strengthening and damp drying, helps Radix Codonopsis QI invigorating; Poria spleen invigorating fortune is wet; Herba Portulacae has effect of heat-clearing and toxic substances removing, loose blood detumescence, and can control hematodiarrhoea pus and blood, Fructus Mume sour-puckery flavor, property is put down, and relieving diarrhea with astringents, promotes the production of body fluid, and is adjuvant drug altogether.Radix Glycyrrhizae QI invigorating and middle emergency, and the poison separating all medicines, can relax again the pungent strong property of Rhizoma Zingiberis Recens for making, and all medicines share, treating both the principal and secondary aspects of a disease, and healthy energy is unobstructed, then evil inverse from removing.

Medicine of the present invention has replenishing QI to invigorate the spleen removing dampness, strengthening vital QI to eliminate pathogenic factors, stomach function regulating antidiarrheal, restrains function that is astringent or styptic treatment for spontaneous sweating, turbid, the dispersing cold for relieving pain of removing toxic substances row.Prescription is the reference Chinese veterinarian eight guiding principles for diagnosis, defensive-qi-nutrient-blood, determining the pathogenesis of ZANG-FU disease based on the differentiation of symptoms and signs theory fully, giving consideration to both the exterior and interior, and QI and blood is ruled together, special by YAOJING, compatibility is careful and precise, embodies again the organic conception of " treating both the principal and secondary aspects of a disease ", embody medication as used military forces, the road of using military forces is essence, and the road of medication is pure prescription characteristic.

Facts have proved of modern veterinary's pharmacological research and clinical prolonged application, it is high that Chinese medicine has overall curative effect, not easily produces drug resistance, residual low, the advantages such as toxic and side effects is little, it has significant inhibitory action to the growth and reproduction of many virus causing diseases, even reaches the pharmacological effect killing cause of disease.The present invention is yellow according to piglet, Hakuri the cause of disease, pathogenesis, clinical pathology and drug mechanism, carry out Chinese medicine compound control piglet Huang, Hakuri, develop evident in efficacy, reliable in quality, application is convenient, cheap compound Chinese medicinal preparation, and apply in Swine Production, for promoting that the sound development of pig industry has very important economy and social meaning.

Medicine of the present invention can directly gavage for pig when concrete use.

The use amount of medicine of the present invention is: therapeutic dose: piglet, 2ml/kg ﹒ BW, 1 time/d, be used in conjunction 3-5 days; Preventive dose: piglet, 1ml/kg ﹒ BW, 1 time/d, be used in conjunction 3-5 days.

Detailed description of the invention

product and preparation embodiment

embodiment 1

Prevent and treat a Chinese medicine composition for piglet Huang, Hakuri, prepared by the component of following weight portion:

Herba Pogostemonis 220 parts; Radix Codonopsis 190 parts; The Rhizoma Atractylodis Macrocephalae 110 parts; Herba Portulacae 110 parts; The Rhizoma Pinelliae 110 parts; 110 parts, Poria; Fructus Mume 110 parts; 65 parts, Rhizoma Zingiberis Recens; Radix Glycyrrhizae Preparata 65 parts.

Control piglet is yellow, the preparation method of the Chinese medicine composition of Hakuri, comprises the following steps:

Get each component by weight, add the water of medical material 5 times of weight, decoct 2 times, each 2 hours, collecting decoction, filtered, filtrate leaves standstill 12 hours, getting supernatant concentration to relative density is 1.20 ~ 1.30, adds ethanol to alcohol content 60%, places, filter, reclaim ethanol, adding water to relative density is 1.10 ~ 1.20, to obtain final product.

Further, add potassium sorbate 1.5 parts, be mixed, cooling 48h, filters with brown aseptic polyester bottles subpackage, and 100 DEG C of flowing steams 30 minutes, obtain oral liquid.

embodiment 2

Prevent and treat a Chinese medicine composition for piglet Huang, Hakuri, prepared by the component of following weight portion:

Herba Pogostemonis 180 parts; Radix Codonopsis 170 parts; The Rhizoma Atractylodis Macrocephalae 90 parts; Herba Portulacae 90 parts; The Rhizoma Pinelliae 90 parts; 90 parts, Poria; Fructus Mume 90 parts; 55 parts, Rhizoma Zingiberis Recens; Radix Glycyrrhizae Preparata 55 parts.

Its preparation method is identical with embodiment 1.

embodiment 3

Control piglet is yellow, the Chinese medicine composition of Hakuri, has been prepared by following component:

Herba Pogostemonis 200g, Radix Codonopsis 180g, Rhizoma Atractylodis Macrocephalae 100g, Herba Portulacae 100g, Rhizoma Pinelliae 100g, Poria 100g, Fructus Mume 100g, Rhizoma Zingiberis Recens 60g, Radix Glycyrrhizae Preparata 60g.

Its preparation method carries out as follows: by weight by above 9 tastes, add the water of medical material 5 times of weight, decocts 2 times, each 2 hours, collecting decoction, filters, and filtrate leaves standstill 12 hours, getting supernatant concentration to relative density is 1.20 ~ 1.30, adds ethanol to alcohol content 60%, places, filter, reclaim ethanol, adding water to relative density is 1.10 ~ 1.20, add potassium sorbate 1.5g, be mixed, cooling 48h, filter with brown aseptic polyester bottles subpackage, 100 DEG C of flowing steams 30 minutes, preserve for subsequent use.

application Example

1) therapeutic test:

The present embodiment adopts random double blind test method to carry out piglet Huang, the Hakuri therapeutic test of various dose treatment natural occurrence, and selects enrofloxacin soluble powder to be positive drug control group.Observe the present invention to piglet Huang, Hakuri therapeutical effect, to inquire into the feasibility that it applies in Production of Livestock and Poultry.

The therapeutic test of, Hakuri yellow to the piglet of natural occurrence: natural occurrence is made a definite diagnosis piglet Huang through clinical diagnosis and laboratory diagnosis, the sick pig of Hakuri is divided into 5 groups at random, often organize 36.1-3 group is for adopting medication therapy groups of the present invention (establishing basic, normal, high dosage three groups respectively); 4th group is enrofloxacin soluble powder positive drug control group; 5th group is positive controls (infecting, not administration).Isolated rearing respectively, the situation such as symptom, healing, death of the sick pig of itemized record.

Medication, administration time: medicine 1 group: every pig to be fed medicine 5ml of the present invention every day, connects and feeds 3 days; Medicine 2 groups: every pig to be fed medicine 10ml of the present invention every day, connects and feeds 3 days; Medicine 3 groups: every pig to be fed medicine 15ml of the present invention every day, connects and feeds 3 days.Positive drug control group: every pig to be fed enrofloxacin soluble powder (by specification use) every day, connects and feeds 3 days; Positive controls: not administration.

experimental result:

After treatment group medicine feed 24h, the spirit of the sick pig of medicine group is better than positive controls, adds up death toll after 36 h, and the sick pig of medicine group is obviously fewer than positive controls death toll; Observe after 48 h, appearance improvement in various degree respectively organized by medicine, and positive controls still has dead successively generation.After 3 d, spirit, the appetite of the sick pig of medicine group take a favorable turn (increase from sucking amount, feeding capacity and find out), and feces is normal.

Test statistics result shows that in medicine high-dose therapy group of the present invention 36 piglets, have 33 recoveries from illness, still have loose bowels, but do not have death for 3, cure rate is 91.6%; In middle dosage treatment group 36 piglets, have 32 recoveries from illness, still have loose bowels, but do not have death for 4, cure rate is 88.9%; In low dose therapy group 36 piglets, have 26 recoveries from illness, still have loose bowels for 8, dead 2, cure rate is 72.2%; In enrofloxacin soluble powder treatment group (matched group) 36 piglets, have 26 recoveries from illness, still have loose bowels for 5, and have 5 death, cure rate is 72.2%; In positive controls (not administration) 36 piglets, have 24 still to have loose bowels, and have 12 death, high, middle dosage treatment group mortality rate is 0.0%, and the sick pig of the treatment group comparatively sick pig of matched group, show as symptom to alleviate, the course of disease shortens, and experiment proves that the high, medium and low dosage of the present invention is yellow to piglet, Hakuri has therapeutical effect, energy relief of symptoms, reduce mortality rate, and height, middle dosage are at reduction mortality rate, improve the effect that the aspects such as cure rate are all better than enrofloxacin soluble powder.High, middle dosage the present invention can reach the effect of survival rate of curing the disease, improve, and both zero differences in 0.05 level, therefore dosage in can adopting during Clinical practice, so not only economic curative effect but also remarkable.

) prophylactic tria

On the pig farm that epidemic situation occurs, the pig that 100 health do not fallen ill is divided into 2 groups at random, and often organize 50, the 1st group is chemoprophylaxis group; 2nd group is matched group; 1st group every pig to gavage medicine 10ml(of the present invention every day and connects and feed 7 days; 2nd group is not added; Two groups of other measures of pig all normally to be sterilized immune programme for children by pig farm.

Result shows: chemoprophylaxis group piglet is yellow, the sickness rate of Hakuri is 3.0%, and matched group sickness rate is 75.0%, and the spirit of medicine group morbidity pig, appetite are all better than matched group, and also comparatively matched group is light for illness symptom.Prevention group morbidity afterwards give with treatment after, cure rate is 86.0%; And matched group is 67.0%.

From result of the test, the present invention has replenishing QI to invigorate the spleen removing dampness, strengthening vital QI to eliminate pathogenic factors, stomach function regulating antidiarrheal, restrains function that is astringent or styptic treatment for spontaneous sweating, turbid, the dispersing cold for relieving pain of removing toxic substances row.In clinical trial process, do not find that this medicine has untoward reaction.High, medium and low dosage is yellow to piglet, Hakuri has good therapeutic effect.The therapeutic effect of low dose group lower than high, middle dosage group, middle and high dosage group there are no significant in mortality rate, cure rate and total effective rate difference.Should according to the weight of the state of an illness and treatment cost, suggestion clinical practice is with middle and high dosage (piglet 10-15ml); As well, 3 ~ 5 days are used in conjunction.

In order to toxic and side effects clearly of the present invention, to making accurately its safety, objective appraisal, for clinical trial medication provides scientific basis, guaranteeing clinical drug safety, having carried out toxicity test of the present invention.

By carrying out LD of the present invention to mice 50show with mtd test, after design dosage oral administration, in 7 days, each group mice behavior sign is normal, does not all occur poisoning symptom and death.Therefore cannot LD be measured 50, and have to maximum dosage-feeding 50g/kg for maximum dose level.After within 8th day, slaughtering, each group mice organs is all without pathological changes, and liver,kidney,spleen histological examination, does not find pathological characters yet.Hemogram and serum GPT Activity determination, result and normal mouse there was no significant difference.

Toxicity and the order of severity is produced because using Chinese herb compound the present invention continuously in order to grasp, and development after drug withdrawal and recovery situation, provide reference for drafting data for clinical drug use dosage.Mice has carried out subacute toxicity test of the present invention, within experimental period, except high dose group affects ingest because drug dose causes greatly palatability difference, all the other respectively organize mouse diet, behavior, and feces is all normal, physically well develop, without any poisoning symptom, weightening finish and nutrition except high dose group and matched group significant difference, all the other there are no significant differences.The hemogram of each group and serum GPT are all in normal range.Histological examination, liver,kidney,spleen etc. are all without obvious poisoning pathological changes.Doubly gavage 30d by the 3-10 of clinical application amount, also have no toxic and side effects, illustrate that the clinical medicine dose of said preparation is very safe.

Medicine of the present invention according to listing terms of packing, in temperature: 40 DEG C ± 2 DEG C, relative humidity: Acceleration study 3 months under 75% ± 5% condition, quality is without significant change.In temperature: 25 DEG C ± 2 DEG C relative humiditys: long term test 24 months under 60% ± 10% condition, quality is without significant change.Above-mentioned result of the test shows, medicine of the present invention under prescribed conditions storage quality is stablized.

Last it is noted that the foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (5)

1. prevent and treat a Chinese medicine composition for piglet Huang, Hakuri, it is characterized in that, prepared by the component of following weight portion: Herba Pogostemonis 200 ± 20 parts; Radix Codonopsis 180 ± 10 parts; The Rhizoma Atractylodis Macrocephalae 100 ± 10 parts; Herba Portulacae 100 ± 10 parts; The Rhizoma Pinelliae 100 ± 10 parts; 100 ± 10 parts, Poria; Fructus Mume 100 ± 10 parts; 60 ± 5 parts, Rhizoma Zingiberis Recens; Radix Glycyrrhizae Preparata 60 ± 5 parts.
2., according to the Chinese medicine composition of the control piglet Huang described in claim 1, Hakuri, it is characterized in that, prepared by the component of following weight portion: Herba Pogostemonis 200 parts; Radix Codonopsis 180 parts; The Rhizoma Atractylodis Macrocephalae 100 parts; Herba Portulacae 100 parts; The Rhizoma Pinelliae 100 parts; 100 parts, Poria; Fructus Mume 100 parts; 60 parts, Rhizoma Zingiberis Recens; Radix Glycyrrhizae Preparata 60 parts.
3. the control piglet described in claim 1 or 2 is yellow, the preparation method of the Chinese medicine composition of Hakuri, comprises the following steps: get each component by weight, adds the water of medical material 5 times of weight, decoct 2 times, each 2 hours, collecting decoction, filter, filtrate leaves standstill 12 hours, and getting supernatant concentration to relative density is 1.20 ~ 1.30, add ethanol to alcohol content 60%, place, filter, reclaim ethanol, adding water to relative density is 1.10 ~ 1.20, to obtain final product.
4. the control piglet described in claim 1 or 2 is yellow, the application of the Chinese medicine composition of Hakuri in preparation control piglet Huang, Hakuri medicine.
5. a control piglet is yellow, the traditional Chinese medicine compound oral liquid of Hakuri, it is characterized in that, yellow containing the control piglet described in claim 1 or 2, the Chinese medicine composition of Hakuri and potassium sorbate, obtain especially by following steps: get each component by weight, add the water of medical material 5 times of weight, decoct 2 times, each 2 hours, collecting decoction, filter, filtrate leaves standstill 12 hours, getting supernatant concentration to relative density is 1.20 ~ 1.30, add ethanol to alcohol content 60%, place, filter, reclaim ethanol, adding water to relative density is 1.10 ~ 1.20, add potassium sorbate 1.5 parts, be mixed, cooling 48h, filter with brown aseptic polyester bottles subpackage, 100 DEG C of flowing steams 30 minutes, obtain.
CN201310301888.8A 2013-07-18 2013-07-18 Traditional Chinese medicine composition capable of preventing and treating piglet yellow and white scours as well as preparation and applications thereof CN103394053B (en)

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CN106310035A (en) * 2016-10-27 2017-01-11 中国农业科学院兰州畜牧与兽药研究所 Traditional Chinese medicine composition capable of preventing paratyphoid fever of lambs, and preparation method thereof

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