CN103191400B - Traditional Chinese medicine compound drug for preventing and treating transmissible gastroenteritis of swine - Google Patents
Traditional Chinese medicine compound drug for preventing and treating transmissible gastroenteritis of swine Download PDFInfo
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- CN103191400B CN103191400B CN201310144692.2A CN201310144692A CN103191400B CN 103191400 B CN103191400 B CN 103191400B CN 201310144692 A CN201310144692 A CN 201310144692A CN 103191400 B CN103191400 B CN 103191400B
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Abstract
The invention discloses a traditional Chinese medicine compound drug for preventing and treating transmissible gastroenteritis of swine. The compound drug disclosed by the invention comprises the components of 150+/-10 parts of wrinkled giant hyssop, 100+/-10 parts of codonopsis pilosula, 100+/-10 parts of white atractylodes rhizome, 50+/-5 parts of radix aconiti carmichaeli (processed), 50+/-5 parts of pinellia ternate, 50+/-5 parts of tuckahoe, 100+/-10 parts of platycodon grandiflorum, 100+/-10 parts of baked ginger, 80+/-10 parts of fructus evodiae, and100+/-5 parts of honey-fried licorice root. The test shows that the traditional Chinese medicine compound drug has the functions of resolving damp with aromatics, detoxifying and evacuating turbid, rescuing from collapse by restoring yang, eliminating cold to stop pain, calming the adverse-rising energy to stop vomiting, replenishing qi to invigorate the spleen, and strengthening body resistance and eliminating evil, and can effectively prevent and treat the transmissible gastroenteritis of swine.
Description
Technical field
The present invention relates to a kind of compound medicine that formed by Chinese medicine, that can prevent and treat transmissible gastroenteritis of swine.
Background technology
Transmissible gastroenteritis of swine (transmissible gastroenteritis of swine, TGE) claim again the gastroenteritis of young pig, be a kind of height contagiousness, vomitting, severe diarrhea, dehydration, cause the viral infectious that two weeks age, interior piglet high mortality was feature.12-24 hour there will be vomiting after with interior Infection in Piglets general 2 week age, then occurs serious water sample or pasty state diarrhoea, and it is yellow that feces is, often accompany indigested ziega, stench, body weight declines rapidly, piglet obviously dewaters, the death in 2-7 days of falling ill, and mortality rate reaches 100%; The 2-3 piglet in age in week, mortality rate is at 0-10%.Morbidity in 2-4 days after ablactation pig infects, performance watery diarrhea, is spurting, feces gray or brown, indivedual pig vomitings were suffered from diarrhoea and are stopped after 5-8 days, seldom dead, but weight loss often shows dysplasia, becomes cad pig.Some sow and the repeated infection of ill piglet close contact, symptom is heavier, fervescence, lactogenic stops, vomiting, inappetence and diarrhoea, some nursing sow does not show clinical symptom yet.
Transmissible gastroenteritis of swine symptom is to cause diarrhea of pigs, vomiting, dehydration, the symptom such as become thin.Its main pathology variation characteristic is intestinal mucosa hyperemia, edema, and intestinal mucosa comes off etc.Diarrhoea sees piglet conventionally, also sees sow, and it has been that piglet growth is obstructed and the high major reason of mortality rate.Bring heavy losses in these years to China's pig industry.The region of being everlasting is popular, the heterogeneous susceptible of patient, and infectiousness is strong, and mortality rate is high, often causes large quantities of piglet death.Very person causes being annihilated, very harmful to pig industry, is badly in need of finding suitable antiviral antibacterials and carrys out immunotherapy targeted autoantibody, becomes a noticeable worldwide problem.At present transmissible gastroenteritis of swine doctor trained in Western medicine be there is no to desirable Therapeutic Method, also without specific drug.The method of taking is just mitigation symptoms, reduces death, shortens the course of disease, reduces loss.For preventing generation and the popular normal employing vaccination therapy of this disease, but vaccine effect is not good enough, and controlling above-mentioned disease completely by vaccine has great difficulty.Application hyper-immune serum, yolk antibody treatment primary disease, although curative effect is better, cost is too high.Without restraint abuse chemical medicine, antibiotic and monomer medicine, both produced the super many drug-induced disease such as quick of polynary drug resistance and receptor, cause again animal products to pollute, jeopardize human food's safe and sanitary.Chinese medicine derives from animal, plant and mineral, contains multiple biological effective components, and wherein most of Chinese medicine is take natural plants as raw material, aboundresources, easily obtain, respond well, cheap, toxic and side effects is small, almost noresidue, without Drug resistance, free from environmental pollution.Therefore, select Chinese medicine preparation to substitute chemical medicine, antibiotic seems particularly important.
Summary of the invention
The invention provides and a kind ofly form with Chinese medicine composition, can be used for preventing and treating the compound medicine of transmissible gastroenteritis of swine.
Compound medicine of the present invention consists of: Herba Pogostemonis 150 ± 10 weight portions, Radix Codonopsis 100 ± 10 weight portions, the Rhizoma Atractylodis Macrocephalae 100 ± 10 weight portions, Radix Aconiti Lateralis Preparata (system) 50 ± 5 weight portions, the Rhizoma Pinelliae 50 ± 5 weight portions, Poria 50 ± 5 weight portions, Radix Platycodonis 100 ± 10 weight portions, Rhizoma Zingiberis Preparatum 100 ± 10 weight portions, Fructus Evodiae 80 ± 10 weight portions, Radix Glycyrrhizae Preparata 100 ± 5 weight portions.Medicine of the present invention in the time of concrete use can more than 10 herbal medicines pulverize, sieve, mix after directly for poultry feeding, also can use again its active ingredient of water extraction to poultry feeding.
Chinese veterinarian thinks that transmissible gastroenteritis of swine belongs to Chinese veterinarian's cholera category, and Chinese veterinarian's cholera is hurried with onset, suddenly outbreak, vomiting and dirarrhea, stomachache or not disease bitterly.Because pathological changes arises from no time, spend freely formal confused, therefore named cholera.The scope of Chinese veterinarian's cholera is wider, comprises the diseases such as cholera, pasracholera, acute gastroenteritis and the bacterial food poisoning of doctor trained in Western medicine.
Primary disease is multiple is born in autumn and winter season, and suffering from poultry has again the greedy cool and rotten situations such as food of turning sour of feed mostly, therefore think mainly due to experiencing due to cold-damp foul gas and unhygienic diet.Due to the foul tired spleen of cold-damp, taste are injured, disorder in ascending and descending, and abnormal ascent-descent between clear YANG and turbid YIN, mechanism of qi is disorderly contrary, does so vomit and diarrhoea to hand over.As said in " danxi's experiential therapy cholera " piece of writing: " inside long-pending to some extent, sense to some extent, causes into vomiting and diarrhoea outward ".Vomiting and diarrhoea because of it,, therefore at short notice, can there is wan and sallow looking in body fluid excessive loss, and orbit sink, and muscle arteries and veins contraction is anxious, the critical syndrome such as extreme cold of the limbs.
Chinese veterinarian thinks that the generation of primary disease is mainly that (1) experiences seasonal pathogen: in the season of autumn and winter, damp transpiration, if it is inappropriate to take good care of oneself, experience the foul pestilential pathogen of cold-damp, or because of greedy cool sleeping in the open, cold-damp invasion, exopathogen oxious gas, strongly fragrantly holds back middle Jiao, all can make taste injured, dysfunction of the spleen in transportation and transformation, disorder of QI movement, disorder in ascending and descending, abnormal ascent-descent between clear YANG and turbid YIN, disorderly, in the intestines and stomach, vomiting and dirarrhea forms.(2) feed unclean: feed unclean, enter the rotten rotten food of turning sour by mistake, or cold and cool feedstuff, can impairing the spleen and stomach, pure and impure mixed forming mutually.
In sum, primary disease is mainly to experience the foul gas of cold-damp, cold-damp disturbing the spleen, deficiency of spleen-QI and stomach-QI, hypoactivity of YANG in middle-JIAO, yang deficiency is raw endogenous cold, stagnates and cause mechanism of qi, and lifting is disorderly contrary, the main fortune transporting of spleen and sending up the lucid YANG, stomach receiving food and drink and the turbid descending the moon, in the present void have cold, lifting dereliction of duty, thus suffer from abdominal pain for vomiting and diarrhea, loss of appetite.Sick deeply few cloudy to cold-evil, in kidney, decline of YANG QI is micro-, and Yinyang is mutually along connecing, thus outward extremity faint contraryly, dislike cold Curled sleeping, Mental fatigue somnolence.Inside vomit not wish drink, stomachache diarrhea.Control and should removing dampness ward off dirty, warming spleen and stomach for dispelling cold, dysentery is controlled in recuperating depleted YANG and rescuing the patient from collapse, spleen invigorating.
Medicine of the present invention is to use
herba Pogostemonispungent temperature cold expelling, removing dampness by means of aromatics, regulating the flow of Qi and the middle Jiao, stomach function regulating is pleased spleen, wards off evil preventing or arresting vomiting, the double the exterior and the interior of controlling;
radix Aconiti Lateralis Preparatapure sun, is kidney-yang the first key medicine of the congenital gate of vitality of tonification, current 12 warps, with inside and outside fastly reaching take warming YANG by trembling with fear as monarch.
rhizoma Zingiberis Preparatumthe sun of warm the middle warmer and go out interior cold, helps Radix Aconiti Lateralis Preparata to stretch to send out a yang-energy, and can stopping nausea and vomiting by lowering the adverse flow of QI, makes gastric qi and suitable;
radix CodonopsisqI invigorating invigorating YANG, spleen invigorating the lucid yang sending up, coordinates Rhizoma Zingiberis, coordinates QI of the spleen and stomach lifting; The pungent temperature cold expelling of Fructus Evodiae, warm liver stomach warming, kind lowering the adverse flow of QI is ministerial drug altogether.
the Rhizoma Pinelliaedampness sending down the abnormal ascending QI, stomach function regulating preventing or arresting vomiting;
the Rhizoma Atractylodis Macrocephalaethe spleen strengthening and damp drying, helps Radix Codonopsis QI invigorating;
poriaspleen invigorating fortune is wet,
radix Platycodonislung qi dispersing profit diaphragm is adjuvant drug altogether.
radix GlycyrrhizaeqI invigorating and middle emergency, and can separate the poison of Radix Aconiti Lateralis Preparata, can relax again Radix Aconiti Lateralis Preparata, the pungent strong property of Rhizoma Zingiberis for making, and all medicines.Healthy energy is unobstructed, evil contrary from removing.
The present invention has that removing dampness by means of aromatics, removing toxic substances row are turbid, recuperating depleted YANG and rescuing the patient from collapse, dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, replenishing QI to invigorate the spleen, strengthening vital QI to eliminate pathogenic factors function.Prescription is fully with reference to Chinese veterinarian's eight guiding principles for diagnosis, defensive-qi-nutrient-blood, determining the pathogenesis of ZANG-FU disease based on the differentiation of symptoms and signs theory, giving consideration to both the exterior and interior, QI and blood is ruled together, special by YAOJING, compatibility is careful and precise, has embodied again " prevention of diseae ", the prevention thought of " preventing exacerbation after being taken ill ", embodied medication as used military forces, the road of using military forces is essence, and the road of medication is pure prescription characteristic.
Facts have proved of modern veterinary's pharmacological research and clinical prolonged application, it is high that Chinese medicine has overall curative effect, is difficult for producing drug resistance, residual low, the advantages such as toxic and side effects is little, its growth and reproduction to many virus causing diseases has significant inhibitory action, even reaches the pharmacological effect of killing cause of disease.The present invention is according to the cause of disease of pig virus diarrhoea, pathogenesis, clinical pathology and drug mechanism, carry out Chinese medicine compound control transmissible gastroenteritis of swine, develop evident in efficacy, reliable in quality, application is convenient, cheap compound Chinese medicinal preparation, and apply in Swine Production, very important economy and social meaning there is for the sound development that promotes pig industry.
The specific embodiment
Below in conjunction with test, the present invention is explained orally.
In the specific embodiment of the present invention, be to use Herba Pogostemonis 15kg, Radix Codonopsis 10kg, Rhizoma Atractylodis Macrocephalae 10kg, Radix Aconiti Lateralis Preparata (system) 5kg, Rhizoma Pinelliae 5kg, Poria 5kg, Radix Platycodonis 10kg, Rhizoma Zingiberis Preparatum 10kg, Fructus Evodiae 8 kg, Radix Glycyrrhizae Preparata 10kg.Accurately take each medicine in upper several ratios, drying is pulverized, and crosses 60 mesh sieves, mixes.Subpackage is for subsequent use.
1) therapeutic test
The present invention adopts random double blind test method to carry out the transmissible gastroenteritis of swine therapeutic test of various dose treatment natural occurrence, and selects the positive medicine matched group of florfenicol.Observe the present invention to transmissible gastroenteritis of swine therapeutical effect, the feasibility of applying to inquire into it in Production of Livestock and Poultry.
The therapeutic test of the transmissible gastroenteritis of swine to natural occurrence: the sick pig that natural occurrence is made a definite diagnosis to transmissible gastroenteritis through clinical diagnosis and laboratory diagnosis is divided into 5 groups, 30 every group at random.1-3 group is for adopting medication therapy groups of the present invention (establishing respectively three groups of basic, normal, high dosage); The 4th group is florfenicol powder positive drug matched group; The 5th group of positive matched group (infecting not administration).Respectively isolated rearing, the situations such as the symptom of the sick pig of itemized record, healing, death.
Medication, administration time: 1 group of medicine: every pig medicine 15g(piglets of the present invention of feeding every day reduces by half), connect and feed 5 days; 2 groups of medicines: every pig medicine 30g(piglets of the present invention of feeding every day reduces by half), connect and feed 5 days; 3 groups of medicines: every pig medicine 45g(piglets of the present invention of feeding every day reduces by half), connect and feed 5 days.Positive drug matched group: every pig (10%) florfenicol powder 20mg/ kg body weight (in florfenicol) of feeding every day, connects and feed 5 days; Positive controls: not administration.
Experimental result: after treatment group medicine feed 24h, the spirit of the sick pig of medicine group is better than positive controls, adds up death toll after 36 h, and the sick pig of medicine group is obviously fewer than positive controls death toll; After 48 h, observe, medicine is respectively organized appearance improvement in various degree, and positive controls still has dead generation successively.After 3 d, spirit, the appetite of the sick pig of medicine group take a favorable turn (increase and find out from sucking amount, feeding capacity), and feces is normal
Test statistics result shows that medicine high-dose therapy group cure rate of the present invention is 65.0%, and mortality rate is 20.1%, and total effective rate is 79.9% respectively; Middle dosage treatment group cure rate is 64.5%, and mortality rate is 20.5%, and total effective rate is 79.5% respectively; Low dose therapy group cure rate is 40.0%, and mortality rate is 60.2%, and total effective rate is 39.8% respectively; Florfenicol treatment group cure rate is 55.0%, and mortality rate is 30.2%, and total effective rate is 69.8%; Age in days positive controls (not administration) mortality rate in 10 days of statistics is 90.0% separately, and age in days height, middle dosage treatment group piglets mortality rate in 10 days of statistics are only 45.0% separately, and the sick pig for the treatment of group is compared with the sick pig of matched group, showing as symptom alleviates, the course of disease shortens, experimental results show that the high, medium and low dosage of the present invention has therapeutical effect to transmissible gastroenteritis of swine disease, energy relief of symptoms, reduce mortality rate, and high, middle dosage is reducing mortality rate, and the aspects such as raising cure rate are all better than the effect of florfenicol.High, middle dosage the present invention can reach the effect of curing the disease, improve survival rate, and both zero differences in 0.05 level, therefore dosage, so not only economic curative effect but also remarkable in can adopting when clinical use.
2) prophylactic tria
The pig farm occurring in epidemic situation, is divided into 2 groups at random by 100 health pig that do not fall ill, and 50 every group, the 1st group is chemoprophylaxis group; The 2nd group is matched group; The 1st group every pig feedstuff every day adds hello medicine 15g(piglets of the present invention and reduces by half), connect and feed 7 days; The 2nd group is not added; Two groups of other measures of pig are all by the pig farm immune programme for children of normally sterilizing.
Result shows: the sickness rate of chemoprophylaxis group transmissible gastroenteritis of swine is 5.0%, and matched group sickness rate is 75.0%, and spirit, the appetite of medicine group morbidity pig is all better than matched group, and illness symptom is also light compared with matched group.Prevention group morbidity afterwards give with treatment after, cure rate is 70.0%; And matched group is 40.0%.
From result of the test, the present invention has removing dampness by means of aromatics, the functions such as row is turbid, recuperating depleted YANG and rescuing the patient from collapse, dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, replenishing QI to invigorate the spleen, strengthening vital QI to eliminate pathogenic factors of detoxifying.In clinical trial process, do not find that this medicine has untoward reaction.High, medium and low dosage has good therapeutic effect to transmissible gastroenteritis of swine disease.The therapeutic effect of low dose group is lower than high, middle dosage group, middle and high dosage group there are no significant aspect mortality rate, cure rate and total effective rate difference.Should be according to the weight of the state of an illness and treatment cost, suggestion clinical practice is with middle dosage (pig 30～50g; Every day, be used in conjunction 3～5 days; Or mixed feeding, every 1kg feedstuff 20～40g) for well, be used in conjunction 3～5 days.
For toxic and side effects clearly of the present invention, to its safety is made accurately, objective appraisal, for clinical trial medication provides scientific basis, guarantee clinical drug safety, carry out toxicity test of the present invention.
By mice is carried out to LD of the present invention
50show with mtd test, by designing after dosage oral administration, in 7 days, each group mice behavior sign is normal, does not all occur poisoning symptom and death.Therefore cannot measure LD
50, and have to be take maximum dosage-feeding 60g/kg as maximum dose level.After within the 8th day, slaughtering, respectively organize mice organs all without pathological changes, liver,kidney,spleen histological examination, does not find pathological characters yet.Hemogram and serum GPT are active to be detected, result and normal mouse there was no significant difference.
In order to grasp because using continuously Chinese herb compound the present invention to produce toxicity and the order of severity, and development and recovery situation after drug withdrawal, reference provided for drafting data for clinical drug use dosage.On mice, carry out subacute toxicity test of the present invention, within experimental period, except high dose group because of drug dose cause greatly palatability poor affect ingest, all the other each group mice diet, behavior, feces is all normal, physically well develop, without any poisoning symptom, weightening finish and nutrition except high dose group and matched group significant difference, all the other there are no significant differences.The hemogram of each group and serum GPT are all in normal range.Histological examination, liver,kidney,spleen etc. are all without obvious poisoning pathological changes.By the 3-10 of the clinical application amount 30d that doubly feeds, also have no toxic and side effects, the clinical medicine dose that said preparation is described is very safe.
Medicine of the present invention is according to listing terms of packing, in temperature: 40 ℃ ± 2 ℃, and relative humidity: accelerate experiment 3 months under 75% ± 5% condition, quality is without significant change.In temperature: 25 ℃ ± 2 ℃ relative humiditys: long term test 24 months under 60% ± 10% condition, quality is without significant change.Above-mentioned result of the test shows, medicine of the present invention storage quality under rated condition is stable.
Claims (1)
1. the traditional Chinese compound medicine for the treatment of or prevention transmissible gastroenteritis of swine, is characterized in that compound medicine consists of:
Herba Pogostemonis 150 ± 10 weight portions, Radix Codonopsis 100 ± 10 weight portions, the Rhizoma Atractylodis Macrocephalae 100 ± 10 weight portions,
Radix Aconiti Lateralis Preparata 50 ± 5 weight portions, the Rhizoma Pinelliae 50 ± 5 weight portions, Poria 50 ± 5 weight portions,
Radix Platycodonis 100 ± 10 weight portions, Rhizoma Zingiberis Preparatum 100 ± 10 weight portions, Fructus Evodiae 80 ± 10 weight portions,
Radix Glycyrrhizae Preparata 100 ± 5 weight portions.
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| CN103394053B (en) * | 2013-07-18 | 2015-04-15 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition capable of preventing and treating piglet yellow and white scours as well as preparation and applications thereof |
| CN106729589A (en) * | 2017-03-14 | 2017-05-31 | 韦煜辉 | Treat the Chinese medicine preparation and preparation method of transmissible gastroenteritis of swine |
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