CN104547997B - A kind of Chinese medicine composition for treating piglet epidemic diarrhea - Google Patents

A kind of Chinese medicine composition for treating piglet epidemic diarrhea Download PDF

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Publication number
CN104547997B
CN104547997B CN201410813288.4A CN201410813288A CN104547997B CN 104547997 B CN104547997 B CN 104547997B CN 201410813288 A CN201410813288 A CN 201410813288A CN 104547997 B CN104547997 B CN 104547997B
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epidemic diarrhea
chinese medicine
medicine composition
piglet epidemic
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CN104547997A (en
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胡桂学
温伟
董浩
邵洪泽
王开
赵艳丽
黄海龙
赵立峰
崔焕忠
王龙涛
张锡全
柏亚铎
齐玮
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Jilin Agricultural University
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Jilin Agricultural University
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
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    • A61K36/488Pueraria (kudzu)
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    • A61K36/489Sophora, e.g. necklacepod or mamani
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention discloses a kind of Chinese medicine composition for treating piglet epidemic diarrhea, its composition by weight is:40 60 parts of the bark of official magnolia, 40 60 parts of anise seed, 40 60 parts of rhizoma zingiberis, 30 50 parts of snake lotus, 30 50 parts of calamint, 30 50 parts of myrobalan, 20 40 parts of potentilla discolor, 20 40 parts of polygonum flaccidum, simmer 20 40 parts of cardamom, 20 40 parts of granatum, the Fen, pivots of kuh-seng 15 35 store 15 35 parts, 15 35 parts of Radix Codonopsis, 15 35 parts of the Radix Astragali, 15 35 parts of the root of kudzu vine, 10 30 parts of Chinese yam, 10 30 parts of the bighead atractylodes rhizome, 10 30 parts of PORIA ALBA.Said medicine dialectical compatibility and is mutually assisted a ruler in governing a country through organic assembling, enhances party's middle benefit gas dispelling cold, is replenished qi to invigorate the spleen, effect of excreting dampness antidiarrheal, so as to reach the purpose for curing piglet epidemic diarrhea.Clinical Treatment Test is proved, treats the cure rate 92.43% of piglet epidemic diarrhea, effective percentage 97.84%.

Description

A kind of Chinese medicine composition for treating piglet epidemic diarrhea
Technical field
The present invention relates to the pharmaceutical composition for the treatment of Animal diseases, more particularly to a kind of medicine for treating piglet epidemic diarrhea Compositions and preparation method thereof.
Background technology
Pig epidemic diarrhea (porcine epidemic diarrhea, PED) is by Porcine epidemic diarrhea virus (Porcine epidemic diarrhea virus, PEDV)The acute infectious enterocolitis infectious disease of a caused boar.Various years Age, each breeding pig can infection morbidity, its characteristics of incidence is:Age in days is small, severe symptoms, and age in days is big, mild symptoms.Main infection way Footpath is alimentary canal.If a pig farm has many nest piglets to be born or wean successively, virus constantly infection can lose maternal antibody Weanling pig, make this disease be in endemicity.In this breeding farm, PED can cause the weaning period of 5~8 week old piglets stupid Solidity is suffered from diarrhoea.Contain a large amount of germs in sick pig and the excrement that pork chop goes out that carries disease germs, be easy to pollution pig house ground, feed, drinking-water, Feed trough, apparatus and sow body surface and teat.Health pig, which is eaten 7~8 days after germ, to fall ill.Chronic person can also be dragged to 2~ Symptom is broken out after March.This sick infection sources is sick pig and the pig that carries disease germs.Rehabilitation pig can carry disease germs the several months.
Motherland's tradition veterinary science thinks that this sick generation is improper mainly due to feeding management, and feeding is unclean, or feed is cold Cool, so that taste sustain damage, pure and impure phase is mixed to be formed.Furthermore evil when experiencing, the season of autumn and winter, damp evil is rising, if it is inappropriate to take good care of oneself, sense By the foul pestilential pathogen of cold-dampness, or because it is greedy it is cool sleep in the open, cold-dampness invasion, visitor's heresy oxious gas is strongly fragrant to hold back middle Jiao, can make taste injured, fortune Change not normal, disorder of qi, disorder in ascending and descending, abnormal ascent-descent between clear YANG and turbid YIN, disorderly in stomach, is suffered from vomiting and diarrhoea and formed.Pig infects this after being ill, main performance For vomiting, diarrhoea and dehydration.Disease rises suddenly, and general sick pig lassitude, abdominal distension in short-term after loss of appetite, that is, are shown in violent diarrhea, Excrement such as water sample, starts as grey or lark, stench, fast and switch to courageous and upright water dysentery, pollution pig house ground, wall and pig body. The colorectal mucosa or fibrinous exudate come off is mixed with excrement, it is abnormal stench.Fever is up to 40 DEG C~40.5 DEG C.Part Affected pig 12~24h after morbidity is dead.The excrement of most of sick pig then switchs to coffee color, wherein with gelatin mucus and Fragment of tissue.Loss of appetite, lassitude, happiness is sleeping, gradually becomes thin, 7~10d of the course of disease, dead or switch to chronic.It is chronic Affected pig progressive emaciation, anaemia, growth retardation.Some rehabilitation pigs after a time, can recur again, occur disease again or repeatedly just Symptom.It is most obvious with piglet and feeder pig symptom.2~4 d dehydrations are dead after piglet is suffered from diarrhoea within 1 week old, the death rate About 50%, the highest death rate is up to 100%.Sick pig body temperature is normal or slightly higher, and spirit is depressed, anorexia or useless exhausted.1 week Age above piglet may die from dehydration, average mortality 50%~90% after continuing 3~4 d diarrhoea;The death rate of growing and fattening pigs For 1%, partial recovery pig impaired development occurs and as cad pig;Inferior clinical symptom is normally behaved as after Adult Pig infection PEDV , spiritual depressed, apocleisis, vomiting, 4~5 d can rehabilitation.
Macroscopic pathological change is only limited to small intestine, and small intestine lesion has characteristic.The piglet that dies of illness dehydration is become thin, subcutaneous dry There is the curdling block of volume yellow-white in dry, stomach.Major lesions are characterized as:The swollen full expansion of intestinal tube, bright in appearance, intestinal wall are thinning.Intestines Full of yellow liquid or with gas in pipe.Mesenterium is congested.Lymphonodi mesenterici oedema.Cut open inspection sick dead pig is most prominent Lesion is in large intestine and caecum section.Intestinal mucosa oedema, bleeding, necrosis, the gelatin mucus of surface attachment.Some sick pig large intestine intracavitary Full of blood red liquid.Stomach and small intestine have Catarrhal lesion.Other organs lesion is not obvious.
For many years, this disease not only gives China's pig industry, or even the pig industry in the whole world all to bring heavy losses.PED often exists One local prevalence, and normal and animal infectious diease mixed infection, cause large quantities of piglets dead, very harmful to pig industry, find A kind of suitable antiviral antibacterials carry out immunotherapy targeted autoantibody, the worldwide problem as the task of top priority.At present to PED doctors trained in Western medicine still Without preferable treatment method, also without preferable medicine.To prevent the sick generation and prevalence frequently with vaccine therapy, but Vaccine effect is not good enough, and control disease has great difficulty.Using hyper-immune serum, Yolk antibody treats this disease, although curative effect is preferably, Cost is too high.Abuse chemical drug, antibiotic and monomer medicine without restraint, had both produced polynary anti-medicine and the super many drug induccd diseases such as quick of acceptor Disease, causes animal products to pollute again, jeopardizes human food safe and healthy.And Chinese medicine has overall curative effect high, resistance is not likely to produce Property, low, the advantages of toxic side effect is small is remained, and cheap, free from environmental pollution, its growth and breeding to many virus causing diseases With significant inhibitory action, the pharmacological effect of cause of disease is even up to killed.Therefore, we are according to the disease of pig virus diarrhoea Cause, pathogenesis, clinical pathology and drug mechanism, carry out the research of compound of Chinese herbal medicine pig epidemic diarrhea, develop It is evident in efficacy, reliable in quality, using convenient, cheap compound Chinese medicinal preparation.
The content of the invention
The technical problem to be solved in the present invention be overcome at present treatment piglet epidemic diarrhea weak point there is provided one Plant draw materials convenient easy, preparation, reduction medicament residue and toxic side effect, and the higher treatment piglet popularity of cheap curative effect The Chinese medicine composition of diarrhoea.We have the advantages that overall curative effect is high, are not likely to produce drug resistance, the low, toxic side effect of residual is small, its There is significant inhibitory action to the growth and breeding of piglet epidemic diarrhea virus, for promoting the sound development of pig industry to have There are highly important economy and social effect.
The invention provides following technical scheme:
A kind of Chinese medicine composition for treating piglet epidemic diarrhea, its composition by weight is:40-60 parts of the bark of official magnolia, anise seed 40-60 parts, 40-60 parts of rhizoma zingiberis, 30-50 parts of snake lotus, 30-50 parts of calamint, 30-50 parts of myrobalan, 20-40 parts of potentilla discolor, polygonum flaccidum 20-40 parts, simmer 20-40 part of cardamom, 20-40 parts of granatum, kuh-seng 15-35 Fen, pivots storage 15-35 parts, 15-35 parts of Radix Codonopsis, the Radix Astragali 15-35 parts, 15-35 parts of the root of kudzu vine, 10-30 parts of Chinese yam, 10-30 parts of the bighead atractylodes rhizome, 10-30 parts of PORIA ALBA.
It is preferred that composition by weight be:
60 parts of the bark of official magnolia, 60 parts of anise seed, 60 parts of rhizoma zingiberis, 50 parts of snake lotus, 50 parts of calamint, 50 parts of myrobalan, 40 parts of potentilla discolor, 40 parts of polygonum flaccidum, simmer 40 parts of cardamom, 40 parts of granatum, the Fen, pivots of kuh-seng 35 store 35 parts, 35 parts of Radix Codonopsis, 35 parts of the Radix Astragali, 35 parts of the root of kudzu vine, 30 parts of Chinese yam, 30 parts of the bighead atractylodes rhizome, 30 parts of PORIA ALBA.
Or be:
40 parts of the bark of official magnolia, 40 parts of anise seed, 40 parts of rhizoma zingiberis, 30 parts of snake lotus, 30 parts of calamint, 30 parts of myrobalan, 20 parts of potentilla discolor, 20 parts of polygonum flaccidum, simmer 20 parts of cardamom, 20 parts of granatum, the Fen, pivots of kuh-seng 15 store 15 parts, 15 parts of Radix Codonopsis, 15 parts of the Radix Astragali, 15 parts of the root of kudzu vine, 10 parts of Chinese yam, 10 parts of the bighead atractylodes rhizome, 10 parts of PORIA ALBA.
Or be:
50 parts of the bark of official magnolia, 50 parts of anise seed, 50 parts of rhizoma zingiberis, 40 parts of snake lotus, 40 parts of calamint, 40 parts of myrobalan, 30 parts of potentilla discolor, 30 parts of polygonum flaccidum, simmer 30 parts of cardamom, 30 parts of granatum, the Fen, pivots of kuh-seng 25 store 25 parts, 25 parts of Radix Codonopsis, 25 parts of the Radix Astragali, 25 parts of the root of kudzu vine, 20 parts of Chinese yam, 20 parts of the bighead atractylodes rhizome, 20 parts of PORIA ALBA.
A further object of the present invention is to provide a kind of Chinese medicine composition for treating piglet epidemic diarrhea, is by following sides It is prepared by method:
Each Chinese medicinal component is weighed by a kind of raw material proportioning for the Chinese medicine composition for treating piglet epidemic diarrhea, by middle web Piao, anise seed, rhizoma zingiberis, She Lian, calamint, myrobalan, potentilla discolor, polygonum flaccidum, stewing cardamom, granatum, kuh-seng, pivot storage, Radix Codonopsis, Huang Stilbene, the root of kudzu vine, Chinese yam, the bighead atractylodes rhizome, PORIA ALBA are crushed, and are then well mixed, plus the water of 6 times of weight soaks 40 minutes;It is put into decoction pot It is interior, decoct 30 minutes, filter out the dregs of a decoction, take filtrate;
Contained crude drug 0.74-0.78g/ml in described filtrate.
A kind of Chinese medicine composition for treating piglet epidemic diarrhea of the present invention, the bark of official magnolia is bitter in taste, pungent, temperature.Enter spleen, it is stomach, big Intestines are passed through.Work(with promoting qi circulation to remove dampness, can especially remove stomach and intestine stagnant gas, eliminating dampness fortune spleen.With controlling dampness seen by piglet epidemic diarrhea The middle burnt, stagnation of the circulation of vital energy is unfavorable etc. good curative effect.Anise seed, warming yang for dispelling cold, regulating qi-flowing for relieving pain is preferable for cold-dampness diarrhea effect.It is dry Jiang Xin, temperature.Enter the heart, spleen, stomach, kidney, lung, large intestine channel.Effect is warming spleen and stomach for dispelling cold, Back to Yang Tongmai.Rhizoma zingiberis is apt to warm stomach and intestine, for The diarrhoea curative effect that deficiency-cold in spleen and stomach occurs is preferable.Three medicine phases compatibilities, with warming yang for dispelling cold, the work(of promoting qi circulation to remove dampness, altogether in side Monarch drug in a prescription.Calamint is pungent, hardship;It is cool in nature.Work(with wind and heat dispersing removing toxic substances.To the card such as enteritis, dysentery curative effect preferably, to a variety of diseases Opportunistic pathogen such as staphylococcus aureus, Pseudomonas aeruginosa and shigella dysenteriae have inhibitory action.Snake lotus nature and flavor are puckery, slight bitter, put down.Tool is clear Heat, detoxifies, convergence, the work(of myogenic.It is commonly used to control dysentery, diarrhoea etc. is demonstrate,proved.Myrobalan is bitter in taste, sour, puckery, temperature, enters lung, large intestine channel, Work(with convergence, puckery intestines, lower gas, antidiarrheal, the effect such as anti-multiple pathogenic microorganisms is used for the card such as chronic diarrhea, protracted dysentery.With wind wheel Dish, She Lian, which match, has the work(of removing toxic substances astringing to arrest diarrhea.Potentilla discolor taste bitter and cold, the work(with clearing heat and detoxicating, hemostasis, stop dysentery.It is special Not for stomachache diarrhea, protracted dysentery has preferable curative effect incessantly.Polygonum flaccidum is the drying herb that polygonaceae plant lies prostrate hair knotweed, and nature and flavor are pungent, Temperature.Return lung, liver, large intestine channel.With removing toxic substances, clearing damp dissipates the stasis of blood, hemostasis.For dysentery, gastroenteritis, the curative effect of disease such as diarrhoea is certain. Two medicine phases compatibility its dispelling wind and eliminating dampness, the effect of astringing to arrest diarrhea is more preferable.Simmer cardamom nature and flavor pungent, temperature.Enter spleen, stomach, large intestine channel.Effect exists In astringing to arrest diarrhea, middle benefit gas promoting the circulation of qi.The kind warm taste of this product, are longer than relieving diarrhea with astringents, it is adaptable to caused by endless diarrhea or deficiency-cold in spleen and stomach Chronic diarrhea, tripe abdominal distention and pain, poor appetite etc..Raw meat cardamom has laxation effect, then has relieving diarrhea with astringents effect after simmering and deoiling.Granatum Nature and flavor are sour, puckery, temperature.Enter large intestine channel.Effect astringing to arrest diarrhea, desinsection.The property of this product convergence is stronger, long suitable for the chronic diarrhea caused by the cold of insufficiency type Dysentery, is often equal with myrobalan, nutmeg, rhizoma zingiberis and uses.Modern pharmacological research proves that this product is to shigella dysenteriae, Pseudomonas aeruginosa, typhoid fever bar Bacterium, tubercle bacillus and various dermatophytes have inhibitory action.Simmer cardamom and the medicine phases of granatum two must play convergence jointly and stop to use Rush down, the work(of middle benefit gas promoting the circulation of qi.Ministerial drug in the said medicine side of collectively constituting.Kuh-seng bitter, it is cold in nature.The thoughts of returning home, liver, stomach, large intestine, bladder Through.It is bitter, trembles with fear.There are heat-clearing and damp-drying drug, desinsection, the work(of diuresis.For hot dysentery, have blood in stool, the card such as jaundice.Pivot stores bitter, cold nature.Return Bladder warp.Inducing diuresis for treating strangurtia, desinsection is antipruritic.To a variety of germs, such as staphylococcus, Pseudomonas aeruginosa, dermatophyte have suppression to make With.Two medicine phases are closed and focus on eliminating dampness, diuresis, antidiarrheal.Bighead atractylodes rhizome nature and flavor are sweet, hardship, temperature.Enter spleen, stomach.With invigorating the spleen and benefiting qi, eliminating dampness is sharp The work(of water.It is the important drugs strengthened the spleen and stomach, the card such as diarrhoea occurred for deficiency-cold in spleen and stomach, tripe abdomen crymodynia, effect is fine, and And invigorating the spleen to dry, and can Li Shui, the card available for retention of water-damp in the body.Chinese yam nature and flavor are sweet, put down.Enter spleen, lung, kidney channel.With strengthening the spleen and stomach, The work(of beneficial lung kidney.This product is not mild-natured dry, and effect is gentle, for the medicine of flat tonifying spleen and stomach, no matter insufficiency of the spleen-yang or stomach yin deficiency, can all be applied. Weakness of the spleen and the stomach, diarrhea etc. is controlled, is often equal with Radix Codonopsis, the bighead atractylodes rhizome, Poria cocos and uses, effect is preferable.Poria cocos nature and flavor are sweet, light, put down.Enter spleen, stomach, The heart, lung, kidney channel.Effect eliminating dampness and diuresis, strengthening spleen and middle warmer.General retention of water-damp or the person that trembles with fear partially, use PORIA ALBA.Because Poria cocos can be good for Spleen and energy dampness removing, energy complementary energy are rushed down.Therefore the diarrhoea occurred to water retention due to hypofunction of the spleen has functions that invigorating spleen to remove dampness antidiarrheal, plays giving consideration to both the incidental and fundamental Effect.The work(of the sharp water of invigorating the spleen to dry is played jointly in just neutralization Chinese yam, bighead atractylodes rhizome phase 5.Root of kudzu vine nature and flavor are sweet, pungent, cool.Enter spleen, stomach Through.Effect is relieving muscles diaphoresis, promotes the production of body fluid to quench thirst, Shengyang Zhixie.The uplifting yang qi in we, inspires taste yang-energy to rise and stop Rush down.Such as match somebody with somebody Radix Codonopsis, bighead atractylodes rhizome medicine, splenasthenic diarrhea can be controlled.Radix Codonopsis nature and flavor are sweet, flat.Enter spleen, lung channel.With tonifying middle-Jiao and Qi, invigorating the spleen The work(promoted the production of body fluid.It is conventional Qi-tonifying drug.For the prolonged illness deficiency of vital energy, lassitude hypodynamia, splenasthenic diarrhea etc., often it is equal with the bighead atractylodes rhizome, Poria cocos and uses, For the prolapse of the anus caused by collapse from qi deficiency, the prolapse of uterus, often equally used with the Radix Astragali, the bighead atractylodes rhizome.Radix Astragali nature and flavor are sweet, tepor.Enter spleen, lung Through.Effect:Tonifying Qi and lifting yang Li Shui etc..The Radix Astragali and Radix Codonopsis are all important Qi-tonifying drugs, it is adaptable to spleen-lung Qi deficiency, eat less and tired, gas Short, diarrhea etc., is often equal with Radix Codonopsis, the bighead atractylodes rhizome, Chinese yam and uses;To prolapse of the anus, prolapse of uterus etc. caused by collapse from qi deficiency, often with Radix Codonopsis etc. Compatibility application.Adjuvant in the said medicine side of collectively constituting.Close and use it, middle benefit gas dispelling cold is played altogether, replenish qi to invigorate the spleen, excreting dampness antidiarrheal Work(.There is preferable curative effect to piglet epidemic diarrhea.
System side's feature:We are replenished qi to invigorate the spleen, excreting dampness antidiarrheal is used in combination with middle benefit gas dispelling cold, and with harmonizing the functional activities of vital QI, dispel table heresy, Treating both the exterior and interior.
Said medicine dialectical compatibility and is mutually assisted a ruler in governing a country through organic assembling, is enhanced party's middle benefit gas dispelling cold, is replenished qi to invigorate the spleen, oozes Effect of wet antidiarrheal, so as to reach the purpose for curing piglet epidemic diarrhea.Clinical Treatment Test proves that we treatment piglet is flowed The cure rate 92.43% of row diarrhoea, effective percentage 97.84%.
Embodiment
Embodiment 1
Composition by weight:60 parts of the bark of official magnolia, 60 parts of anise seed, 60 parts of rhizoma zingiberis, 50 parts of snake lotus, 50 parts of calamint, 50 parts of myrobalan, turn over White 40 parts of grass, 40 parts of polygonum flaccidum, simmer 40 parts of cardamom, 40 parts of granatum, the Fen, pivots of kuh-seng 35 store 35 parts, 35 parts of Radix Codonopsis, 35 parts of the Radix Astragali, 35 parts of the root of kudzu vine, 30 parts of Chinese yam, 30 parts of the bighead atractylodes rhizome, 30 parts of PORIA ALBA.Add water by 6 times of total dose, both 4290 parts of water, after decoction into 917 parts of decoctions, both every milliliter of decoction was containing about 0.78 gram of crude drug.
Embodiment 2
Composition by weight:40 parts of the bark of official magnolia, 40 parts of anise seed, 40 parts of rhizoma zingiberis, 30 parts of snake lotus, 30 parts of calamint, 30 parts of myrobalan, turn over White 20 parts of grass, 20 parts of polygonum flaccidum, simmer 20 parts of cardamom, 20 parts of granatum, the Fen, pivots of kuh-seng 15 store 15 parts, 15 parts of Radix Codonopsis, 15 parts of the Radix Astragali, 15 parts of the root of kudzu vine, 10 parts of Chinese yam, 10 parts of the bighead atractylodes rhizome, 10 parts of PORIA ALBA.Add water by 6 times of total dose, both 2370 parts of water, after decoction into 534 parts of decoctions, both every milliliter of decoction was containing about 0.74 gram of crude drug.
Embodiment 3
Composition by weight:50 parts of the bark of official magnolia, 50 parts of anise seed, 50 parts of rhizoma zingiberis, 40 parts of snake lotus, 40 parts of calamint, 40 parts of myrobalan, turn over White 30 parts of grass, 30 parts of polygonum flaccidum, simmer 30 parts of cardamom, 30 parts of granatum, the Fen, pivots of kuh-seng 25 store 25 parts, 25 parts of Radix Codonopsis, 25 parts of the Radix Astragali, 25 parts of the root of kudzu vine, 20 parts of Chinese yam, 20 parts of the bighead atractylodes rhizome, 20 parts of PORIA ALBA.Add water by 6 times of total dose, both 3450 parts of water, after decoction into 757 parts of decoctions, both every milliliter of decoction was containing about 0.76 gram of crude drug.
Embodiment 4
Weighed by embodiment 1,2 or 3 drug ratios, be put into pot for boiling chinese traditional medicine, added water by proportional quantity, first soaked before decocting 40 minutes;Then heating is boiled, keeping temperature, is decocted 40 minutes, slagging-off, and it is that one kind treats piglet epidemic diarrhea to take filtrate Chinese medicine composition
Embodiment 1 gavages the medicine prepared slices of Chinese crude drugs and added water 4290 parts, and concentration filtrate is to 917 parts;
Embodiment 2 gavages the medicine prepared slices of Chinese crude drugs and added water 2370 parts, and concentration filtrate is to 534 parts;
Embodiment 3 gavages the medicine prepared slices of Chinese crude drugs and added water 3450 parts, and concentration filtrate is to 757 parts;
Experimental example
Instructions of taking:
1st, dose:By decoction made from embodiment 1, embodiment 4, by 4ml/kg body weight doses, it is divided into two parts, the upper and lower noon Respectively gavage once;By decoction made from embodiment 2, embodiment 4, by 2ml/kg body weight doses, it is divided into two parts, the upper and lower noon respectively fills Take once;By decoction made from embodiment 3, embodiment 4, by 3ml/kg body weight doses, it is divided into two parts, the upper and lower noon respectively gavages one It is secondary.
2nd, medicine time:One course for the treatment of totally 5 days, daily perfusion twice of upper and lower noon is gavaged in feeding previous hour.
3rd, medicine temperature control system:40 DEG C or so warmly take.
Avoid item:Feeding management is strengthened to ill piglet during treatment medication, it is ensured that sufficient drinking-water, be fed for soft easy The feed of digestion.
Criterion of therapeutical effect:Treat the traditional Chinese medicine composition for treating piglet epidemic diarrhea of piglet epidemic diarrhea, efficacy determination master Whether to be disappeared according to piglet epidemic diarrhea symptom.Medication 5 days is course for the treatment of, and specific curative effect is divided into three-level:
Cure:Piglet epidemic diarrhea symptom all disappears;
Take a turn for the better:Piglet epidemic diarrhea symptom partial disappearance;
It is invalid:Piglet epidemic diarrhea symptom is not improved.
In recent years, we treat a course for the treatment of in the thousands of examples of the single therapeutic grice diarrhoea such as multiple pig farms and veterinary hospital, Cure rate 92.43%, effective percentage 97.84%.
Clinical effect trial
1. method:The pig farm of cub's pig epidemic diarrhea or individual raiser six are published, generation piglet stream is selected altogether The piglet 1459 of row diarrhoea, age 7-35 age in days.Ill piglet is divided into four groups, is respectively of the present invention group, the ginseng Siberian cocklebur bighead atractylodes rhizome Dissipate side's group, two Siberian cocklebur Pingwei San side groups and control group.
Present invention group is the pharmaceutical composition for treating grice diarrhoea as obtained by embodiment 3,4.
Shenling baizhu powder used in shenling baizhu powder group is derived from《The formulary of peaceful benevolent dispensary》, consisting of 45 parts of Radix Codonopsis, the bighead atractylodes rhizome 45 Part, 45 parts of Poria cocos, 45 parts of honey-fried licorice root, 45 parts of Chinese yam, 60 parts of Semen Lablab Album, 30 parts of Semen Nelumbinis, 30 parts of balloonflower root, 30 parts of coix seed, sand 30 parts of benevolence.It is put into pot for boiling chinese traditional medicine, adds water appropriate, first soak 40 minutes;Then heating is boiled, keeping temperature, decocts 40 points Clock, slagging-off is taken in filtrate, filtrate per 0.76 gram of milliliter contained.The party is the conventional prescription of cub splenasthenic diarrhea.Press daily 3ml/kg body weight doses, are divided into two parts, and the upper and lower noon respectively gavages once.It is used in conjunction 5 days.
Two Siberian cocklebur Pingwei Sans used in two Siberian cocklebur Pingwei San groups are derived from《The formulary of peaceful benevolent dispensary》In Pingwei San add taste, consisting of fry 35 parts of rhizoma atractylodis, 30 parts of the bark of official magnolia, 25 parts of dried orange peel, 30 parts of umbellate pore furgus, 12 parts of the banksia rose are put into pot for boiling chinese traditional medicine, are added water appropriate, are first soaked Bubble 40 minutes;Then heating is boiled, keeping temperature, is decocted 40 minutes, slagging-off, is taken in filtrate, filtrate per milliliter contained 0.76 Gram.3ml/kg body weight doses are pressed daily, are divided into two parts, the upper and lower noon respectively gavages once.It is used in conjunction 5 days.
Control group is without any drug therapy.
Treatment time is a course for the treatment of, i.e., 5 days, once, dosage pressed 3ml/kg body weight for daily upper and lower noon each medication.
The affected animal of table 1 is grouped and primary treatments
2. efficacy determination:
Criterion of therapeutical effect:Treat the traditional Chinese medicine composition for treating piglet epidemic diarrhea of piglet epidemic diarrhea, efficacy determination master Whether to be disappeared according to piglet epidemic diarrhea symptom.Medication 5 days is course for the treatment of, and specific curative effect is divided into three-level:
Cure:Piglet epidemic diarrhea symptom all disappears;
Take a turn for the better:Piglet epidemic diarrhea symptom partial disappearance;
It is invalid:Piglet epidemic diarrhea symptom is not improved.
3. result:1459 ill piglets are by different dosage regimens, after the treatment by a course for the treatment of, and each group is controlled Therapeutic effect is shown in Table 2.
The various therapeutic scheme therapeutic effects of table 2
From table 2, three groups of medicines have different therapeutic effects to grice diarrhoea, wherein controlling curative effect with of the present invention group Preferably, cure rate is up to 92.43%, and total effective rate 97.84%, pole is significantly higher than other two groups of (P for fruit< 0.01);Join Siberian cocklebur white Art dissipates group and taken second place, and again, and control group does not have therapeutic action to two Siberian cocklebur Pingwei San groups.Statistical result shows, shenling baizhu powder Difference is not notable (P ﹥ 0.05) between group and two Siberian cocklebur Pingwei San groups, and shenling baizhu powder group and two Siberian cocklebur Pingwei San groups are with compareing Group difference extremely significantly (P< 0.01).
It was verified that medicine of the present invention is through organic assembling, dialectical compatibility and mutually assist a ruler in governing a country, it is clearing heat and detoxicating to enhance the party, Effect of dampness removing and diarrhea-relieving, has preferable curative effect for piglet piglet transmissible gastroenteritis, so as to reach the purpose of healing.Using A kind of obtained treatment piglet piglet of preparation method for the pharmaceutical composition for treating piglet piglet transmissible gastroenteritis of the present invention passes The pharmaceutical composition of metachromia gastroenteritis has that cost is low, it is easy to prepare, and has no toxic side effect and evident in efficacy.Should for clinical treatment Disease provides a kind of practicable new drug.Clinical practice proves, the cure rate 92.43% of the medicine, effective percentage 97.84%.
It is above-mentioned that pharmaceutical composition of the treatment piglet piglet transmissible gastroenteritis and preparation method thereof is entered with reference to embodiment Capable detailed description, is illustrative rather than limited, can include several embodiments according to limited scope, therefore Changing and modifications in the case where not departing from present general inventive concept, should belong within protection scope of the present invention.

Claims (6)

1. a kind of Chinese medicine composition for treating piglet epidemic diarrhea, its bulk drug composition by weight is:40-60 parts of the bark of official magnolia, fennel Fragrant seed 40-60 parts, 40-60 parts of rhizoma zingiberis, 30-50 parts of snake lotus, 30-50 parts of calamint, 30-50 parts of myrobalan, 20-40 parts of potentilla discolor, 20-40 parts of polygonum flaccidum, simmer 20-40 part of cardamom, 20-40 parts of granatum, kuh-seng 15-35 Fen, pivots storage 15-35 parts, 15-35 parts of Radix Codonopsis, 15-35 parts of the Radix Astragali, 15-35 parts of the root of kudzu vine, 10-30 parts of Chinese yam, 10-30 parts of the bighead atractylodes rhizome, 10-30 parts of PORIA ALBA.
2. a kind of Chinese medicine composition for treating piglet epidemic diarrhea according to claim 1, it is characterised in that its weight Measuring component is:60 parts of the bark of official magnolia, 60 parts of anise seed, 60 parts of rhizoma zingiberis, 50 parts of snake lotus, 50 parts of calamint, 50 parts of myrobalan, potentilla discolor 40 Part, 40 parts of polygonum flaccidum, 40 parts of cardamom of stewing, 40 parts of granatum, 35 parts of the Fen, pivots of kuh-seng 35 storage, 35 parts of Radix Codonopsis, 35 parts of the Radix Astragali, the root of kudzu vine 35 Part, 30 parts of Chinese yam, 30 parts of the bighead atractylodes rhizome, 30 parts of PORIA ALBA.
3. a kind of Chinese medicine composition for treating piglet epidemic diarrhea according to claim 1, it is characterised in that its weight Measuring component is:40 parts of the bark of official magnolia, 40 parts of anise seed, 40 parts of rhizoma zingiberis, 30 parts of snake lotus, 30 parts of calamint, 30 parts of myrobalan, potentilla discolor 20 Part, 20 parts of polygonum flaccidum, 20 parts of cardamom of stewing, 20 parts of granatum, 15 parts of the Fen, pivots of kuh-seng 15 storage, 15 parts of Radix Codonopsis, 15 parts of the Radix Astragali, the root of kudzu vine 15 Part, 10 parts of Chinese yam, 10 parts of the bighead atractylodes rhizome, 10 parts of PORIA ALBA.
4. a kind of Chinese medicine composition for treating piglet epidemic diarrhea according to claim 1, it is characterised in that its weight Measuring component is:50 parts of the bark of official magnolia, 50 parts of anise seed, 50 parts of rhizoma zingiberis, 40 parts of snake lotus, 40 parts of calamint, 40 parts of myrobalan, potentilla discolor 30 Part, 30 parts of polygonum flaccidum, 30 parts of cardamom of stewing, 30 parts of granatum, 25 parts of the Fen, pivots of kuh-seng 25 storage, 25 parts of Radix Codonopsis, 25 parts of the Radix Astragali, the root of kudzu vine 25 Part, 20 parts of Chinese yam, 20 parts of the bighead atractylodes rhizome, 20 parts of PORIA ALBA.
5. a kind of Chinese medicine composition for treating piglet epidemic diarrhea, it is prepared by following methods:
A kind of raw material proportioning of Chinese medicine composition for treating piglet epidemic diarrhea as described in claim 1, weighs each Chinese medicine Component, by Cortex Magnoliae Officinalis, anise seed, rhizoma zingiberis, She Lian, calamint, myrobalan, potentilla discolor, polygonum flaccidum, simmer cardamom, granatum, kuh-seng, Pivot storage, Radix Codonopsis, the Radix Astragali, the root of kudzu vine, Chinese yam, the bighead atractylodes rhizome, PORIA ALBA are crushed, and are well mixed, plus the water of 6 times of weight soaks;It is put into decoction In pot, decoct, filter out the dregs of a decoction, take filtrate.
6. according to a kind of Chinese medicine composition for treating piglet epidemic diarrhea of claim 5, it is characterised in that:In described filtrate Contained crude drug 0.74-0.78g/ml.
CN201410813288.4A 2014-12-24 2014-12-24 A kind of Chinese medicine composition for treating piglet epidemic diarrhea Expired - Fee Related CN104547997B (en)

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