CN103230574B - Traditional Chinese medical composition for treating porcine epizootic diarrhea and application thereof - Google Patents

Traditional Chinese medical composition for treating porcine epizootic diarrhea and application thereof Download PDF

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CN103230574B
CN103230574B CN201310147391.5A CN201310147391A CN103230574B CN 103230574 B CN103230574 B CN 103230574B CN 201310147391 A CN201310147391 A CN 201310147391A CN 103230574 B CN103230574 B CN 103230574B
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porcine epizootic
epizootic diarrhea
pig
traditional chinese
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CN103230574A (en
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李锦宇
王贵波
罗超应
谢家声
郑继方
罗永江
辛蕊华
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Sichuan province Qiang mountain animal husbandry Polytron Technologies Inc
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Lanzhou Institute of Animal Husbandry and Veterinary Medicine CAAS
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Abstract

The invention discloses a traditional Chinese medical composition for treating porcine epizootic diarrhea. The composition comprises the following components in parts by weight as follows; 80+/-5 parts of honeysuckle, 150+/-10 parts of Agastache rugosus, 80+/-5 parts of Codonopsis pilosula, 80+/-5 parts of Rhizoma Atractylodis Macrocephalae, 10+/-5 parts of Mangnolia officinalis, 100+/-5 parts of Pinellia ternate, 80+/-5 parts of Poria cocos, 50+/-5 parts of Poria cocos and 80+/-5 parts of liquorice. The traditional Chinese medical composition disclosed by the invention has the advantages of high integral curative effect, difficulty in generation of tolerance, low residue, small toxic and side effects and the like, has the remarkable inhibiting effect to growth and propagation of many virus pathogenies, even has the pharmacological effect of killing pathogenies, and has very important economic and social meanings for promoting healthy development of pig industry.

Description

A kind of Chinese medicine composition and application thereof for the treatment of porcine epizootic diarrhea
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly, relate to a kind of Chinese medicine composition and application thereof for the treatment of porcine epizootic diarrhea.
Background technology
Porcine epizootic diarrhea (PED) is to cause a kind of acute infectious intestinal disease of pig by Porcine epidemic diarrhea virus (porcine epidemic diarrhea virus, PEDV).Mainly cause porcine epizootic diarrhea.Various ages, each product boar all can infection morbidities, and the sickness rate of suckling pig, feeder pig, growing and fattening pigs can reach 100%, and sow sickness rate is 15%~90%.Its characteristics of incidence is: age in days is little, severe symptoms, and age in days is large, mild symptoms.1 week age, the suckling pig dehydration of being everlasting after diarrhoea 3~4 d was dead, and case fatality rate reaches 80%.Wean pig, growing and fattening pigs symptom is lighter, sustainable 4~7 d that suffer from diarrhoea, and only there is vomiting and anorexia in Adult Pig.
Porcine epizootic diarrhea symptom is to cause diarrhea of pigs, vomiting, dehydration, the symptom such as become thin.Its main pathology variation characteristic is that intestinal mucosa is congested, edema, and intestinal mucosa comes off etc.Diarrhoea sees piglet conventionally, also sees sow, and it has been that piglet growth is obstructed and the high major reason of mortality rate.At present, PED is worldwide widely current, and to pig industry, has brought serious economic loss.When particularly the autumn and winter change according to the season, piglet sickness rate is up to 90%, and mortality rate is up to 95%, approximately has 70% pig farm affected by this disease.Bring heavy losses in these years to China's pig industry.The region of being everlasting is popular, the heterogeneous susceptible of patient, and infectiousness is strong, and mortality rate is high, often causes large quantities of piglets dead.Very person causes being annihilated, very harmful to pig industry, is badly in need of finding suitable antiviral antibacterials and carrys out immunotherapy targeted autoantibody, becomes a noticeable worldwide problem.At present transmissible gastroenteritis of swine doctor trained in Western medicine be there is no to desirable Therapeutic Method, also without specific drug.The method of taking is just mitigation symptoms, reduces death, shortens the course of disease, reduces loss.For preventing generation and the popular normal employing vaccination therapy of this disease, but vaccine effect is not good enough, and by vaccine, controlling above-mentioned disease completely has great difficulty.Application hyper-immune serum, yolk antibody treatment primary disease, although curative effect is better, cost is too high.Without restraint abuse chemical medicine, antibiotic and monomer medicine, both produced the super many drug-induced disease such as quick of polynary drug resistance and receptor, cause again animal products to pollute, jeopardize human food's safe and sanitary.Chinese medicine derives from animal, plant and mineral, contains multiple biological effective components, and wherein most of Chinese medicine is to take natural plants as raw material, aboundresources, easily obtain, respond well, cheap, toxic and side effects is small, almost noresidue, without Drug resistance, free from environmental pollution.Therefore, select Chinese medicine preparation to substitute chemical medicine, antibiotic seems particularly important.
Chinese veterinarian thinks that porcine epizootic diarrhea belongs to Chinese veterinarian " cold cholera " category, and Chinese veterinarian's cholera is hurried with onset, suddenly outbreak, vomiting and dirarrhea, stomachache or not disease bitterly.Because pathological changes arises from no time, spend freely formal confused, therefore named cholera.The scope of Chinese veterinarian's cholera is wider, comprises the diseases such as cholera, pasracholera, acute gastroenteritis and bacterial food poisoning of doctor trained in Western medicine. 
Primary disease is multiple is born in autumn and winter season, and suffering from poultry has again the greedy cool and rotten situations such as food of turning sour of feed mostly, therefore think mainly due to experiencing due to cold-damp foul gas and unhygienic diet.Due to the foul tired spleen of cold-damp, taste are injured, disorder in ascending and descending, and abnormal ascent-descent between clear YANG and turbid YIN, mechanism of qi is disorderly contrary, so vomit and diarrhoea to hand over, does.As said in a < < danxi's experiential therapy cholera > > piece of writing: " inside long-pending to some extent, sense to some extent, causes into vomiting and diarrhoea outward ".Because of it, vomiting and diarrhoea,, therefore at short notice, can there is wan and sallow looking in body fluid excessive loss, and orbit sink, and muscle arteries and veins contraction is anxious, the critical syndrome such as extreme cold of the limbs.
Chinese veterinarian thinks that the generation of primary disease is mainly that (1) feeds unclean: feeds unclean, enters the rotten rotten food of turning sour by mistake, or cold and cool feedstuff, can impairing the spleen and stomach, and pure and impure mixed forming mutually.(2) experience seasonal pathogen: in the season of autumn and winter, damp is rising, if it is inappropriate to take good care of oneself, experience the foul pestilential pathogen of cold-damp, or because of greedy cool sleeping in the open, cold-damp invasion, exopathogen oxious gas, strongly fragrantly holds back middle Jiao, all can make taste injured, dysfunction of the spleen in transportation and transformation, disorder of QI movement, disorder in ascending and descending, abnormal ascent-descent between clear YANG and turbid YIN, disorderly, in the intestines and stomach, vomiting and dirarrhea forms.  
Primary disease is mainly to experience the foul gas of cold-damp, cold-damp disturbing the spleen, and deficiency of spleen-QI and stomach-QI, hypoactivity of YANG in middle-JIAO, yang deficiency is raw endogenous cold, and cause mechanism of qi, stagnate, lifting is disorderly contrary, the main fortune transporting of spleen and sending up the lucid YANG, stomach receiving food and drink and the turbid descending is cloudy, in the present void have cold, lifting dereliction of duty, thus suffer from abdominal pain for vomiting and diarrhea, loss of appetite.Sick deeply few cloudy to cold-evil, Yinyang is mutually along connecing, thus outward extremity faint contraryly, E Han Curled is sleeping, Mental fatigue somnolence.Inside vomit not wish drink, stomachache diarrhea.Control and should removing dampness ward off dirty, warming spleen and stomach for dispelling cold, dysentery is controlled in spleen invigorating.
Facts have proved of modern veterinary's pharmacological research and clinical prolonged application, it is high that Chinese medicine has whole curative effect, is difficult for producing drug resistance, residual low, the advantages such as toxic and side effects is little, its growth and reproduction to many virus causing diseases has significant inhibitory action, even reaches the pharmacological effect of killing cause of disease.Therefore, we are according to the cause of disease of pig virus diarrhoea, pathogenesis, clinical pathology and drug mechanism, carry out Chinese medicine compound control transmissible gastroenteritis of swine, develop evident in efficacy, reliable in quality, application is convenient, cheap compound Chinese medicinal preparation, and apply in Swine Production, for promoting the sound development of pig industry to there is very important economy and social meaning.
Summary of the invention
The technical problem to be solved in the present invention is to overcome existing defect, a kind of Chinese medicine composition and application thereof for the treatment of porcine epizootic diarrhea is provided, this Chinese medicine composition have whole curative effect high, be difficult for to produce drug resistance, residual low, the advantage such as toxic and side effects is little, its growth and reproduction to many virus causing diseases has significant inhibitory action, even can reach the pharmacological effect of killing cause of disease, for promoting the sound development of pig industry to there is very important economy and social meaning.
In order to solve the problems of the technologies described above, the invention provides following technical scheme:
Treat a Chinese medicine composition for porcine epizootic diarrhea, it is grouped into by the one-tenth of following weight portion:
Flos Lonicerae: 80 ± 5 parts, Herba Pogostemonis: 150 ± 10 parts, Radix Codonopsis: 80 ± 5 parts, the Rhizoma Atractylodis Macrocephalae: 80 ± 5 parts, Cortex Magnoliae Officinalis: 100 ± 5 parts, the Rhizoma Pinelliae: 100 ± 5 parts, Poria: 80 ± 5 parts, Rhizoma Zingiberis Recens: 50 ± 5 parts, Radix Glycyrrhizae: 80 ± 5 parts.
Preferably, it is grouped into by the one-tenth of following weight portion:
Flos Lonicerae: 80 parts, Herba Pogostemonis: 150 parts, Radix Codonopsis: 80 parts, the Rhizoma Atractylodis Macrocephalae: 80 parts, Cortex Magnoliae Officinalis: 100 parts, the Rhizoma Pinelliae: 100 parts, Poria: 80 parts, Rhizoma Zingiberis Recens: 50 parts, Radix Glycyrrhizae: 80 parts.
The application of the Chinese medicine composition for the treatment of porcine epizootic diarrhea of the present invention in preparation treatment porcine epizootic diarrhea medicine.
Using method: medicine can be pulverized, sieve, mix the rear direct poultry feeding that supplies while specifically using, also can use again its active ingredient of water extraction to poultry feeding.
Use amount: as the pig of every kg body weight gives the medicine of 3-5 gram.
the present invention has following beneficial effect:
Medicine of the present invention is to use the pungent temperature cold expelling of Herba Pogostemonis, removing dampness by means of aromatics, and regulating the flow of Qi and the middle Jiao, stomach function regulating is pleased spleen, wards off evil preventing or arresting vomiting, and the double the exterior and the interior of controlling is for monarch.Flos Lonicerae removing toxic substances is warded off dirty; Cortex Magnoliae Officinalis circulation of qi promoting removing dampness, the chest stuffiness relieving relieving distension; The sun of Rhizoma Zingiberis Recens warm the middle warmer and go out interior cold, helps Herba Pogostemonis to stretch to send out a yang-energy, and can stopping nausea and vomiting by lowering the adverse flow of QI, makes gastric qi and suitable; Radix Codonopsis QI invigorating invigorating YANG, spleen invigorating the lucid yang sending up, coordinates Rhizoma Zingiberis, coordinates QI of the spleen and stomach lifting; Be ministerial drug altogether.Rhizoma Pinelliae dampness sending down the abnormal ascending QI, stomach function regulating preventing or arresting vomiting; Rhizoma Atractylodis Macrocephalae the spleen strengthening and damp drying, helps Radix Codonopsis QI invigorating; Poria spleen invigorating fortune is wet, is adjuvant drug altogether.Radix Glycyrrhizae QI invigorating and middle emergency, and can separate the poison of Radix Aconiti Lateralis Preparata, can relax again Radix Aconiti Lateralis Preparata, the pungent strong property of Rhizoma Zingiberis for making, and all medicines.Healthy energy is unobstructed, evil contrary from removing.
The present invention has that removing dampness by means of aromatics, removing toxic substances row are turbid, dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, replenishing QI to invigorate the spleen, strengthening vital QI to eliminate pathogenic factors function.Prescription is fully with reference to Chinese veterinarian's eight guiding principles for diagnosis, defensive-qi-nutrient-blood, determining the pathogenesis of ZANG-FU disease based on the differentiation of symptoms and signs theory, giving consideration to both the exterior and interior, QI and blood is ruled together, special by YAOJING, compatibility is careful and precise, has embodied again " prevention of diseae ", the prevention thought of " preventing exacerbation after being taken ill ", embodied medication as used military forces, the road of using military forces is essence, and the road of medication is pure prescription characteristic.
The specific embodiment
product embodiments:
embodiment 1
The Chinese medicine composition for the treatment of porcine epizootic diarrhea, it is grouped into by the one-tenth of following weight portion:
Flos Lonicerae: 85 parts, Herba Pogostemonis: 160 parts, Radix Codonopsis: 85 parts, the Rhizoma Atractylodis Macrocephalae: 85 parts, Cortex Magnoliae Officinalis: 105 parts, the Rhizoma Pinelliae: 105 parts, Poria: 85 parts, Rhizoma Zingiberis Recens: 55 parts, Radix Glycyrrhizae: 85 parts.
embodiment 2
The Chinese medicine composition for the treatment of porcine epizootic diarrhea, it is grouped into by the one-tenth of following weight portion:
Flos Lonicerae: 75 parts, Herba Pogostemonis: 140 parts, Radix Codonopsis: 75 parts, the Rhizoma Atractylodis Macrocephalae: 75 parts, Cortex Magnoliae Officinalis: 95 parts, the Rhizoma Pinelliae: 95 parts, Poria: 75 parts, Rhizoma Zingiberis Recens: 45 parts, Radix Glycyrrhizae: 75 parts.
embodiment 3
The Chinese medicine composition for the treatment of porcine epizootic diarrhea, it is grouped into by the one-tenth of following weight portion:
Flos Lonicerae: 80 parts, Herba Pogostemonis: 150 parts, Radix Codonopsis: 80 parts, the Rhizoma Atractylodis Macrocephalae: 80 parts, Cortex Magnoliae Officinalis: 100 parts, the Rhizoma Pinelliae: 100 parts, Poria: 80 parts, Rhizoma Zingiberis Recens: 50 parts, Radix Glycyrrhizae: 80 parts.
application Example
In the present embodiment, be to use Flos Lonicerae 8kg, Herba Pogostemonis 15 kg, Radix Codonopsis 8 kg, the Rhizoma Atractylodis Macrocephalae 8 kg, Cortex Magnoliae Officinalis 10 kg, the Rhizoma Pinelliae 10 kg, Poria 8 kg, Rhizoma Zingiberis Recens 5 kg, Radix Glycyrrhizae 8 kg.Accurately take according to the above ratio each medicine, drying is pulverized, and crosses 60 mesh sieves, mixes, and subpackage is standby.
prophylactic tria
In epidemic situation, pig farm occurs, 100 health pig that do not fall ill is divided into 2 groups at random, 50 every group, the 1st group is chemoprophylaxis group; The 2nd group is matched group; The 1st group every pig feedstuff every day adds hello this product 15g(piglets and reduces by half), connect and feed 7 days; The 2nd group is not added; Two groups of other measures of pig are all by the pig farm immune programme for children of normally sterilizing.
Result shows: the sickness rate of chemoprophylaxis group porcine epizootic diarrhea is 15.0%, and matched group sickness rate is 82.0%, and spirit, the appetite of medicine group morbidity pig is all better than matched group, and illness symptom is also light compared with matched group.Prevention group morbidity give afterwards with treatment after, cure rate is 73.0%; And matched group is 39.0%.
therapeutic test
The present invention adopts random double blind test method to carry out the porcine epizootic diarrhea therapeutic test of various dose treatment natural occurrence, and selects the positive medicine matched group of florfenicol.Observe the present invention to porcine epizootic diarrhea therapeutical effect, the feasibility of applying to inquire into it in Production of Livestock and Poultry.
Therapeutic test to the porcine epizootic diarrhea of natural occurrence: the sick pig that natural occurrence is made a definite diagnosis to porcine epizootic diarrhea through clinical diagnosis and laboratory diagnosis is divided into 5 groups, 30 every group at random.1-3 group is treatment group (basic, normal, high dosage); The 4th group is florfenicol powder positive drug matched group; The 5th group of positive matched group (infecting not administration).Isolated rearing respectively, the situations such as the symptom of the sick pig of itemized record, healing, death.
Medication, administration time: 1 group of medicine: every pig this product 15g(piglets of feeding every day reduces by half), connect and feed 5 days; 2 groups of medicines: every pig this product 30g(piglets of feeding every day reduces by half), connect and feed 5 days; 3 groups of medicines: every pig this product 45g(piglets of feeding every day reduces by half), connect and feed 5 days.Positive drug matched group: every pig this product (10%) florfenicol powder 20mg/ kg body weight (in florfenicol) of feeding every day, connects and feed 5 days; Positive controls: not administration.
Experimental result: after treatment group medicine feed 24h, the spirit of the sick pig of medicine group is better than positive controls, adds up death toll after 36 h, and the sick pig of medicine group is obviously fewer than positive controls death toll; After 48 h, observing, there is improvement in various degree in each group of medicine, and positive controls still has dead generation successively.After 3 d, spirit, the appetite of the sick pig of medicine group take a favorable turn (from sucking amount, feeding capacity, increase and find out), and feces is normal
Statistical result shows that height, middle dosage treatment group cure rate are 65.0%, mortality rate, and total effective rate is 26.5%, 78.5% respectively; Positive controls (not administration) mortality rate (in 10 ages in days) is 92.0%, high, middle dosage treatment group mortality rate (in 10 ages in days) is 43.0%, and the sick pig for the treatment of group is compared with the sick pig of matched group, show as symptom and alleviate, the course of disease shortens, and experimental results show that the high, medium and low dosage of the present invention has therapeutical effect to Porcine Epidemic Diarrhea, energy relief of symptoms, reduce mortality rate, and high, middle dosage is reducing mortality rate, improves the effect that the aspects such as cure rate are all better than florfenicol.High, middle dosage the present invention can reach the effect of curing the disease, improve survival rate, and both zero differences in 0.05 level, therefore dosage, so not only economic curative effect but also remarkable in can adopting during clinical use.
From result of the test, the present invention has removing dampness by means of aromatics, the functions such as row is turbid, recuperating depleted YANG and rescuing the patient from collapse, dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, replenishing QI to invigorate the spleen, strengthening vital QI to eliminate pathogenic factors of detoxifying.In clinical trial process, do not find that this medicine has untoward reaction.High, medium and low dosage has good therapeutic effect to Porcine Epidemic Diarrhea.The therapeutic effect of low dose group is lower than high, middle dosage group, middle and high dosage group there are no significant aspect mortality rate, cure rate and total effective rate difference.Should be according to the weight of the state of an illness and treatment cost, suggestion clinical practice is with middle dosage (pig 30~50g; Every day, be used in conjunction 3~5 days; Or mixed feeding, every 1kg feedstuff 20~40g) for well, be used in conjunction 3~5 days.
For toxic and side effects clearly of the present invention, to its safety is made accurately, objective appraisal, for clinical trial medication provides scientific basis, guarantee clinical drug safety, carried out toxicity test of the present invention.
By mice being carried out to LD50 of the present invention and mtd test shows, after design dosage oral administration, respectively organize mice behavior sign in 7 days normal, all there is not poisoning symptom and death.Therefore cannot measure LD50, and have to take maximum dosage-feeding 70g/kg as maximum dose level.After within the 8th day, slaughtering, each organizes mice organs all without pathological changes, and pathological characters is not found in liver,kidney,spleen histological examination yet.Hemogram and serum GPT are active to be detected, result and normal mouse there was no significant difference.
In order to grasp because using continuously Chinese herb compound the present invention to produce toxicity and the order of severity, and the development after drug withdrawal and recovery situation, for drafting data for clinical drug use dosage, provide reference.On mice, carried out subacute toxicity test of the present invention, within experimental period, except high dose group because of drug dose cause greatly palatability poor affect ingest, all the other respectively organize mice diet, behavior, and feces is all normal, physically well develop, without any poisoning symptom, weightening finish and nutrition except high dose group and matched group significant difference, all the other there are no significant differences.The hemogram of each group and serum GPT are all in normal range.Histological examination, liver,kidney,spleen etc. are all without obvious poisoning pathological changes.By the 3-10 of the clinical application amount 30d that doubly feeds, also have no toxic and side effects, the clinical medicine dose that said preparation is described is very safe.
Medicine of the present invention is according to listing terms of packing, in temperature: 40 ℃ ± 2 ℃, and relative humidity: accelerate experiment 3 months under 75% ± 5% condition, quality is without significant change.In temperature: 25 ℃ ± 2 ℃ relative humiditys: under 60% ± 10% condition, long term test is 24 months, and quality is without significant change.
Above-mentioned result of the test shows, medicine of the present invention storage quality under rated condition is stable.
Finally it should be noted that: the foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although the present invention is had been described in detail with reference to previous embodiment, for a person skilled in the art, its technical scheme that still can record aforementioned each embodiment is modified, or part technical characterictic is wherein equal to replacement.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims (3)

1. a Chinese medicine composition for the treatment of porcine epizootic diarrhea, is characterized in that, it is grouped into by the one-tenth of following weight portion:
Flos Lonicerae: 80 ± 5 parts, Herba Pogostemonis: 150 ± 10 parts, Radix Codonopsis: 80 ± 5 parts, the Rhizoma Atractylodis Macrocephalae: 80 ± 5 parts, Cortex Magnoliae Officinalis: 100 ± 5 parts, the Rhizoma Pinelliae: 100 ± 5 parts, Poria: 80 ± 5 parts, Rhizoma Zingiberis Recens: 50 ± 5 parts, Radix Glycyrrhizae: 80 ± 5 parts.
2. the Chinese medicine composition for the treatment of porcine epizootic diarrhea according to claim 1, is characterized in that, it is grouped into by the one-tenth of following weight portion:
Flos Lonicerae: 80 parts, Herba Pogostemonis: 150 parts, Radix Codonopsis: 80 parts, the Rhizoma Atractylodis Macrocephalae: 80 parts, Cortex Magnoliae Officinalis: 100 parts, the Rhizoma Pinelliae: 100 parts, Poria: 80 parts, Rhizoma Zingiberis Recens: 50 parts, Radix Glycyrrhizae: 80 parts.
3. the application of the Chinese medicine composition for the treatment of porcine epizootic diarrhea claimed in claim 1 in preparation treatment porcine epizootic diarrhea medicine.
CN201310147391.5A 2013-04-25 2013-04-25 Traditional Chinese medical composition for treating porcine epizootic diarrhea and application thereof Active CN103230574B (en)

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CN103977372A (en) * 2014-05-13 2014-08-13 山东新希望六和集团有限公司 Traditional Chinese medicine additive used for treating porcine epizootic diarrhea and preparing method thereof
CN104012778A (en) * 2014-06-17 2014-09-03 武汉诺见生物技术有限公司 Traditional Chinese medicine growth promoting additive for animal feed, and preparation method and application thereof
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CN110302300A (en) * 2019-08-16 2019-10-08 咸阳职业技术学院 A kind of herbal composite for treating pig epidemic diarrhea

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