CN101601822A - A kind of medicine for the treatment of infantile cough and laryngeal stridor and preparation method thereof - Google Patents

Abstract

A kind of medicine for the treatment of infantile cough and laryngeal stridor, be stir-baked SEMEN ARMENIACAE AMARUM, Folium Perillae, Fructus Trichosanthis, Bombyx Batryticatus, Fructus Aurantii, Herba Pogostemonis, Cortex Magnoliae Officinalis, Endothelium Corneum Gigeriae Galli, the Rhizoma Atractylodis Macrocephalae, Poria, Arisaema Cum Bile, Flos Lonicerae, Radix Isatidis, Semen Sinapis Albae, Concretio Silicea Bambusae, Rhizoma Dioscoreae, Radix Glycyrrhizae, Fructus Crataegi, Semen Raphani to be decocted with water the decocting liquid that obtains be condensed into thick paste, behind precipitate with ethanol, get supernatant concentration and make granule.Medicine wind and heat dispersing of the present invention to be taking stopgap measures, and replenishing QI to invigorate the spleen, improving inspiration by invigorating the kidney to be effecting a permanent cure, treating both the principal and secondary aspects of a disease, and relieving cough and asthma through clinical observation, is used for the treatment of infantile cough, laryngeal stridor, and total effective rate is 87.5%, and curative effect is really, rapidly.

Description

A kind of medicine for the treatment of infantile cough and laryngeal stridor and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of infantile cough and laryngeal stridor, particularly relating to a kind of is the Chinese medicine preparation of the treatment infantile cough and laryngeal stridor of feedstock production with Chinese medicine, and the preparation method of this medicine.

Background technology

The modal symptom of infantile respiratory tract infection is heating, cough, laryngeal stridor etc.The children respiratory rich blood vessel, trachea, bronchus internal diameter are narrow, and mucosa is tender, various infection such as easy as rolling off a log generation such as upper respiratory tract infection, acute pharyngitis, laryngitis, tracheitis, asthmatic bronchitis.Above-mentioned disease is main disease with cough all.Cough is a modal lung pattern disease in children's's period, no matter is diseases caused by exogenous pathogenic factor or internal injury, sends out and respectful falling as long as influence lung qi a surname, all can cause cough.Children's's healthy energy in period is not filled, weakened defensive QI, and lung being a delicate viscus closes fur outward, so easily experience exopathogen.In recent years, because environmental pollution is serious day by day, climate change is frequent, and the anaphylaxis chemical substance increases, and the cough patient is also more and more many, and the child is relatively poor to adaptive capacity to environment and immunity because the internal organs growth is incomplete as yet, so the prevalence growth is faster.

For the treatment of cough, doctor trained in Western medicine mainly is based on antibiotic and cough medicine at present.But the life-time service antibiotic causes the normal flora imbalance of human body easily, and causes problem such as drug resistance, and these problems more seem for children's and particularly protrude.And for the cough that causes owing to virus, antibiotic generally is difficult to play effect.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine medicine for the treatment of infantile cough and laryngeal stridor, this drug dose is little, and drug effect is rapid, and therapeutic effect is good.

Medicine of the present invention is that feedstock production obtains by following parts by weight of traditional Chinese medicines:

Stir-baked SEMEN ARMENIACAE AMARUM 9～12 Folium Perillaes 2～3

Fructus Trichosanthis 9～12 Bombyx Batryticatus 2～6

Fructus Aurantii 9～12 Herba Pogostemoniss 2～6

Cortex Magnoliae Officinalis 6～10 Endothelium Corneum Gigeriae Galli 10～15

The Rhizoma Atractylodis Macrocephalae 9～12 Poria 9～12

Arisaema Cum Bile 3～6 Flos Loniceraes 12～15

Radix Isatidis 9～12 Semen Sinapis Albaes 3～6

Concretio Silicea Bambusae 3～6 Rhizoma Dioscoreaes 9～12

Radix Glycyrrhizae 6～10 Fructus Crataegi 12～15

Semen Raphani 12～15.

Said medicine can be made any dosage form on the pharmaceutics, as tablet, pill, powder, capsule etc., the preferred dosage form of the present invention is a granule.

The concrete preparation method of medicine of the present invention being made granule is:

The crude drug of above-mentioned parts by weight is decocted with water 2 times, and each 1.5～2h merges 2 times decocting liquid, filter, leave standstill 24h, get supernatant concentration and become thick paste, put coldly, add ethanol, fully stir, make to contain alcohol amount and reach 60%, leave standstill 24h, the leaching supernatant, remove ethanol, be condensed into thick paste, add an amount of Icing Sugar, granulate behind the mixing, drying obtains granule.

Children's's internal organs are tender and lovely, and shape gas does not fill, the young sun of young the moon, and body and resistance against diseases are poor, and cold again temperature can not self-regulated, and diet can not be experienced the heresy or the internal injury diet of six climate exopathogens from joint, then abnormal rising of lung-QI occurs and coughs, and dysfunction of the spleen in transportation poly-ly wets into expectorant and causes a disease.Children's's skin is thin, weakened defensive QI, and exopathogen is attacked the people, and lung being a delicate viscus stands in the breach, and causes inhibited pulmonary QI, and the respectful mistake department of falling can not regulating fluid apssage, and the gas superinverse is coughed.Again because of pure-YANG constitution of infants and children, easily cold easily heat, easily empty easily real, after the sense heresy, evil heat-transformation and impairment of body fluid, refining liquid becomes expectorant, so cough with copious phlegm.Moreover children's's the spleen tending to insufficiency usually, the eating cold and uncooked food excessively savoury, impairing the spleen and stomach, transformation failure of spleen, water is wet to be stranded in taste, retardance air flue and make us coughing.The traditional Chinese medical science is thought its source of cough one disease at spleen, and it is marked on lung, and the fundamental cause of water disease being in the kidney must be asked its principle according to curing the disease, and should give wind and heat dispersing earlier and control its mark, and back reuse replenishing QI to invigorate the spleen, improving inspiration by invigorating the kidney Zhi Qiben obtain promising result to reach treating both the principal and secondary aspects of a disease.

In the prescription of the present invention, the stir-baked SEMEN ARMENIACAE AMARUM expelling phlegm for arresting cough, relieving asthma; Folium Perillae is delivered cold expelling, regulates the flow of vital energy and is sought; Fructus Trichosanthis clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens; Bombyx Batryticatus expelling wind to relieve convulsion, dissipating phlegm and resolving masses; The Fructus Aurantii transforming phlegm and dispersing accumulations; Herba Pogostemonis and in ward off dirty damp eliminating; The expectorant of Cortex Magnoliae Officinalis warming middle-JIAO dampness; The Endothelium Corneum Gigeriae Galli removing food stagnancy stagnates, strengthening the spleen and stomach; Rhizoma Atractylodis Macrocephalae spleen reinforcing stomach reinforcing, dampness and in; Poria eliminating dampness and diuresis, strengthening the spleen stomach function regulating; Arisaema Cum Bile drying dampness to eliminate phlegm, expelling wind for relieving convulsion; The Flos Lonicerae heat-clearing and toxic substances removing; The Radix Isatidis heat-clearing and toxic substances removing; Semen Sinapis Albae promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, removing obstruction in the collateral to relieve pain; Concretio Silicea Bambusae clear heat and eliminate phlegm, the arresting convulsion of the cool heart; The Rhizoma Dioscoreae strengthening the spleen and tonifying the lung, the benefit of reinforcing the kidney is smart; Fructus Crataegi helps digestion long-pending; Semen Raphani therapeutic method to keep the adverse QI flowing downwards Dingchuan, eliminate indigestion and phlegm; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.All medicines share, wind and heat dispersing, replenishing QI to invigorate the spleen, and improving inspiration by invigorating the kidney, relieving cough and asthma are used for the treatment of infantile cough, laryngeal stridor, and curative effect is really, rapidly.

For further investigating the clinical efficacy and the safety of medicine of the present invention, we select 128 routine infantile cough patients that the curative effect of Drug therapy infantile cough of the present invention, laryngeal stridor is carried out clinical observation.

128 routine cases are divided into two groups at random, every group 64 example.Male 33 examples in the matched group, women 31 examples; 1 years old 3 age example, 2～3 years old 5 example, 4～5 years old 16 example, 6～7 years old 15 example, 8～9 years old 15 example, 10 years old 10 example, average 5.87 years old; The cough light night in daytime heavy person's 50 examples, person's 14 examples of not laying equal stress on round the clock; Cough impassable patient 55 examples, heating person's 16 examples, pharyngeal congestion, antiadoncus person 50 examples, night sweat person 39 examples, pulmonary's respiratory murmur is thick, person's 45 examples that have the rale.Male 34 examples in the treatment group, women 30 examples; 1 years old 4 age example, 2～3 years old 5 example, 4～5 years old 18 example, 6～7 years old 10 example, 8～9 years old 17 example, 10 years old 8 example, average 5.61 years old; The cough light night in daytime heavy person's 49 examples, person's 15 examples of not laying equal stress on round the clock; Expectoration impassable patient 56 examples, heating person's 15 examples, pharyngeal congestion, antiadoncus person 52 examples, night sweat person 40 examples, pulmonary's respiratory murmur is thick, person's 42 examples that have the rale.Two groups of cases credit are by statistics analysed difference not statistically significant (P＞0.05), have comparability.All cases are all diagnosed with reference to the diagnostic criteria of infantile cough in " Pediatrics of Chinese Medicine ".

The oral cold cough syrup of matched group, 1mL/ (inferior year), every day 3 times; Cefalexin capsule 20～40mg/ (kgd), divide 4 times oral.Abdominal distention shows the author and adds ER KANG NING, gastric enzyme mixture, ranitidine etc.; Inappetence, the frequent person of nausea and vomiting add vitamin B6, polyzyme tablets etc.The treatment group adopts medicine of the present invention to treat.

Criterion of therapeutical effect

Cure: the disappearance of coughing night or cough, no expectorant sound between larynx, heating person's body temperature is reduced to normally, and the whole body simultaneous phenomenon is alleviated fully; Take a turn for the better: the sx of coughing night or cough, expectoration reduces, and General Symptoms makes moderate progress; Invalid: as to cough night or symptom such as cough is not seen improvement.

Curative effect comparative result after two groups of cases are treated sees Table 1.

Curative effect after the table 1 liang group case treatment relatively

The specific embodiment

Embodiment 1

It is evenly mixed preferably to choose most impurity, screening stir-baked SEMEN ARMENIACAE AMARUM 900g, Folium Perillae 200g, Fructus Trichosanthis 900g, Bombyx Batryticatus 200g, Fructus Aurantii 900g, Herba Pogostemonis 200g, Cortex Magnoliae Officinalis 600g, Endothelium Corneum Gigeriae Galli 1000g, Rhizoma Atractylodis Macrocephalae 900g, Poria 900g, Arisaema Cum Bile 300g, Flos Lonicerae 1200g, Radix Isatidis 900g, Semen Sinapis Albae 300g, Concretio Silicea Bambusae 300g, Rhizoma Dioscoreae 900g, Radix Glycyrrhizae 600g, Fructus Crataegi 1200g, the Semen Raphani 1200g after the dry in the sun, add water 30Kg and decoct 2h, filter, add water 30Kg again and decoct 1.5h, merge 2 times decocting liquid, leave standstill 24h.Get supernatant concentration and become thick paste, put coldly, add ethanol and make and contain the alcohol amount and reach 60%, leave standstill 24h after fully stirring, filter.Get supernatant and remove ethanol, be condensed into thick paste, add an amount of Icing Sugar, granulate behind the mixing, drying obtains granule.

Embodiment 2

It is evenly mixed preferably to choose most impurity, screening stir-baked SEMEN ARMENIACAE AMARUM 1200g, Folium Perillae 300g, Fructus Trichosanthis 1200g, Bombyx Batryticatus 600g, Fructus Aurantii 1200g, Herba Pogostemonis 600g, Cortex Magnoliae Officinalis 1000g, Endothelium Corneum Gigeriae Galli 1500g, Rhizoma Atractylodis Macrocephalae 1200g, Poria 1200g, Arisaema Cum Bile 600g, Flos Lonicerae 1500g, Radix Isatidis 1200g, Semen Sinapis Albae 600g, Concretio Silicea Bambusae 600g, Rhizoma Dioscoreae 1200g, Radix Glycyrrhizae 1000g, Fructus Crataegi 1500g, the Semen Raphani 1500g after the dry in the sun, add water 40Kg and decoct 2h, filter, add water 35Kg again and decoct 1.5h, merge 2 times decocting liquid, leave standstill 24h.Get supernatant concentration and become thick paste, put coldly, add ethanol and make and contain the alcohol amount and reach 60%, leave standstill 24h after fully stirring, filter.Get supernatant and remove ethanol, be condensed into thick paste, add an amount of Icing Sugar, granulate behind the mixing, drying obtains granule.

Embodiment 3

It is evenly mixed preferably to choose most impurity, screening stir-baked SEMEN ARMENIACAE AMARUM 1000g, Folium Perillae 600g, Fructus Trichosanthis 1000g, Bombyx Batryticatus 600g, Fructus Aurantii 1000g, Herba Pogostemonis 600g, Cortex Magnoliae Officinalis 1000g, Endothelium Corneum Gigeriae Galli 1500g, Rhizoma Atractylodis Macrocephalae 1000g, Poria 1000g, Arisaema Cum Bile 800g, Flos Lonicerae 1500g, Radix Isatidis 1000g, Semen Sinapis Albae 600g, Concretio Silicea Bambusae 600g, Rhizoma Dioscoreae 1000g, Radix Glycyrrhizae 1000g, Fructus Crataegi 1500g, the Semen Raphani 1500g after the dry in the sun, add water 40Kg and decoct 2h, filter, add water 35Kg again and decoct 1.5h, merge 2 times decocting liquid, leave standstill 24h.Get supernatant concentration and become thick paste, put coldly, add ethanol and make and contain the alcohol amount and reach 60%, leave standstill 24h after fully stirring, filter.Get supernatant and remove ethanol, be condensed into thick paste, add an amount of Icing Sugar, granulate behind the mixing, drying obtains granule.

Embodiment 4

Infant Liu, woman, 4 years old.Because of heating, cough was eaten laryngeal stridor 7 days less, defeated antibiotics, and oral multiple effect of drugs is not good.The inquiry state of an illness, because of polyphagia raw food before the first quarter moon, the back by few food catch a cold again, generate heat, cough, laryngeal stridor.Kowtow abdominal distention, rolling pulse, red tip of the tongue, white little being bored with of tongue.Use Drug therapy of the present invention, the cough rale disappears the infant rehabilitation.

Embodiment 5

Infant is appointed certain, man, 5 years old.Fever and cough, 37.8 ℃ of body temperature, pharyngitis is hard and dry, the few food of cough.Because of the transfusion heterodyne, his father brings diagnosis and treatment.The inquiry cause of disease, sick cause is eaten cold drinks and snachs and is caused few food, future trouble fever and cough, pharyngalgia.Fully recover after taking medicine of the present invention.

Claims (3)

1, a kind of medicine for the treatment of infantile cough and laryngeal stridor is to be that feedstock production obtains by following parts by weight of traditional Chinese medicines:

Stir-baked SEMEN ARMENIACAE AMARUM 9～12 Folium Perillaes 2～3

Fructus Trichosanthis 9～12 Bombyx Batryticatus 2～6

Fructus Aurantii 9～12 Herba Pogostemoniss 2～6

Cortex Magnoliae Officinalis 6～10 Endothelium Corneum Gigeriae Galli 10～15

The Rhizoma Atractylodis Macrocephalae 9～12 Poria 9～12

Arisaema Cum Bile 3～6 Flos Loniceraes 12～15

Radix Isatidis 9～12 Semen Sinapis Albaes 3～6

Concretio Silicea Bambusae 3～6 Rhizoma Dioscoreaes 9～12

Radix Glycyrrhizae 6～10 Fructus Crataegi 12～15

Semen Raphani 12～15.

2, the medicine of treatment infantile cough and laryngeal stridor according to claim 1 is characterized in that described medicine is made granule.

3, the preparation method of the medicine of the described treatment infantile cough and laryngeal stridor of claim 2 is that the crude drug with above-mentioned parts by weight decocts with water each 1.5～2h 2 times, merge 2 times decocting liquid, filter, leave standstill 24h, get supernatant concentration and become thick paste, put coldly, add ethanol, fully stir, make to contain the alcohol amount and reach 60%, leave standstill 24h, the leaching supernatant is removed ethanol, is condensed into thick paste, add an amount of Icing Sugar, granulate behind the mixing, drying obtains granule.