CN105560444B - Tibetan medicine composition for treating yak gastroenteritis and preparation method and application thereof - Google Patents
Tibetan medicine composition for treating yak gastroenteritis and preparation method and application thereof Download PDFInfo
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- CN105560444B CN105560444B CN201610050423.3A CN201610050423A CN105560444B CN 105560444 B CN105560444 B CN 105560444B CN 201610050423 A CN201610050423 A CN 201610050423A CN 105560444 B CN105560444 B CN 105560444B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
the invention provides a Tibetan medicine composition for treating yak gastroenteritis, which comprises the following raw material medicines in parts by weight: 200 parts of polygonum divaricatum, 180 parts of gentiana ussuriensis, 180 parts of celery, 180 parts of cumin celery, 160 parts of clematis glauca and 100 parts of pyrus ussuriensis. The invention also provides a preparation method and application thereof. The Tibetan medicine composition has the characteristics of obvious clinical curative effect, low side effect, no residue, low cost, convenience in use and the like, and has a good treatment effect on the yak gastroenteritis. Meanwhile, the use of the medicine can effectively reduce or reduce the use amount of antibiotics and chemical synthetic medicines in the treatment of yak gastroenteritis, eliminate the threat of medicine residue on food safety and public health, and meet the social requirements of providing safe and pollution-free animal-derived food and human health.
Description
Technical Field
The invention belongs to the technical field of Tibetan medicines, and particularly relates to a Tibetan medicine composition for treating yak gastroenteritis and a preparation method and application thereof.
Background
The yaks are special cattle species growing in high-cold and high-altitude areas, about 1300 more than ten thousand yaks exist in China, account for more than 92% of the total number of the yaks in the world, and are mainly distributed in high-cold and high-altitude grassland such as Qinghai, Tibet, Sichuan and Gansu. Yak gastroenteritis is a common and frequent disease of yaks, and is caused by multiple occurrences of yak gastroenteritis due to changeable climate and alternation of cold and heat in spring and autumn, and death is caused by the gastroenteritis. The disease is mostly caused by that yaks eat moldy and unclean forage or drink dirty water, and the weather changes suddenly or is cold or hot. The Tibetan veterinarian considers that the gastroenteritis is an acute inflammation caused by the internal invasion of damp, heat, cold and summer-heat or internal injury of food and drink with unclean yin, and the downward flow of damp and heat or downward flow of cold and dampness is stopped in the stomach or intestines, and the Tibetan language is called 'run and collect with good luck'. Clinically, diseased yaks mainly show depression, reduced or abolished appetite, increased body temperature, pulse and respiration, hyperactive bowel sounds at the beginning of diseases, weakened middle and later stages, thin excrement like a water sample and foul smell; abdominal pain, reddening mouth or reddish with yellow tongue coating, yellow thick tongue coating or yellow greasy tongue coating when sick livestock look around the abdomen when lying; in severe cases, dehydration symptoms appear, and even death occurs. The disease is one of important diseases damaging yaks, and brings huge economic loss to the livestock industry in the Tibetan region.
At present, antibiotics are common medicines for treating the disease, but the drug resistance of pathogenic bacteria is generated due to the long-term use of a large amount of antibiotics, the clinical dosage is larger and the curative effect is worse. Meanwhile, drug residues also threaten public health and food safety. Therefore, the research of the high-efficiency and safe medicine which is not easy to generate drug resistance and has low residue is an urgent problem to be solved for preventing and treating the yak gastroenteritis.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides a Tibetan medicine composition for treating yak gastroenteritis, which is safe to use, difficult to generate drug resistance and low in residue and has good drug effect; therefore, the invention also provides a preparation method and application of the Tibetan medicine composition.
The invention provides a Tibetan medicine composition for treating yak gastroenteritis, which comprises the following raw material medicines in parts by weight: 200 parts of polygonum divaricatum, 180 parts of gentiana ussuriensis, 180 parts of celery, 180 parts of cumin celery, 160 parts of clematis glauca and 100 parts of pyrus ussuriensis.
The second purpose of the invention is to provide a preparation method of the Tibetan medicine composition, which comprises the steps of mixing the raw materials according to the formula amount, adding water, decocting for 1-3 times, combining the liquid medicines, filtering and sterilizing to obtain the Tibetan medicine composition.
Preferably, the preparation method comprises the following steps: weighing 200 parts of polygonum divaricatum, 180 parts of gentiana wushuensis, 180 parts of celery, 180 parts of cumin celery, 160 parts of clematis glauca and 100 parts of pyrus ussuriensis, putting the weighed materials in a stainless steel barrel, adding 8000ml of deionized water, decocting, boiling, continuing to decoct for 1 hour, and pouring out liquid medicine; adding 5000ml deionized water, decocting, boiling, decocting for 1 hr, pouring out the medicinal liquid, mixing the two decoctions, diluting to 1000ml, filtering, stirring, packaging, and sterilizing to obtain oral liquid.
The third purpose of the invention is to provide the application of the Tibetan medicine composition in preparing the medicine for treating yak gastroenteritis.
The Tibetan medicine composition can be prepared into medicines of various dosage forms by taking the Tibetan medicine composition as an effective component according to the existing method in the prior art. The Tibetan medicine composition has certain treatment effect on yak gastroenteritis.
the invention provides a Tibetan medicine composition for treating yak gastroenteritis, and provides a preparation method and application thereof. The six medicines are all traditional Tibetan medicines, and the functions of the raw materials are as follows:
Bing fen san Liang Zi, Tibetan Min Ni ai Luo, bitter, sour and astringent in flavor, has the actions of clearing heat and stopping diarrhea. It can be used for treating gastritis, and heat accumulation in large and small intestine.
Wunu gentian: tibetan famous gang Ga is poor, bitter in taste and cool in nature, and has the effects of clearing heat, removing toxicity and stopping diarrhea. It can be used for treating gastrointestinal ulcer and heat diarrhea.
Tibetan pimpinella: tibet name, tile, sweet, pungent, bitter, and hot, and has effects of invigorating stomach and dispelling cold; is mainly used for treating dyspepsia and dragon disease.
Cumin celery and ZangMinsla have pungent and sweet taste, have the effects of promoting stomach fire, resolving food stagnation and warming middle energizer, and are mainly used for treating stomach cold, abdominal distention, dyspepsia and other symptoms.
The glaucous clematis has sweet and bitter taste and mild property, enters the spleen and stomach channels, has the effects of removing food retention and removing food stagnation, detoxifying and expelling pus and the like, and is mainly used for treating diseases such as dyspepsia, diarrhea and the like.
Sichuan pear: the Tibetan Zanbaixing Luomanie is bought, sour and sweet in taste and warm in nature, and has the effects of relieving dyspepsia and removing blood stasis; it can be used for treating dyspepsia and diarrhea.
The Tibetan medicine composition is prepared by combining a plurality of medicines according to the pathogenesis, pathogenesis and clinical symptoms of yak gastroenteritis and the theories of traditional Chinese medicine veterinarian and Tibetan veterinarian according to the prescription and prevention and treatment principles of clearing heat and removing toxicity, warming middle-jiao and dispelling cold and relieving diarrhea with astringents, has the characteristics of obvious clinical curative effect, low side effect, no residue, low cost, convenient use and the like, and has good treatment effect on the yak gastroenteritis. Meanwhile, due to the adoption of the form of the traditional Chinese medicine composition, when the disease is treated, the use amount of antibiotics and chemosynthesis medicines in treating yak gastroenteritis can be effectively reduced, the threat of medicine residues to food safety and public health is eliminated, and the social requirements of providing safe and pollution-free animal-derived food and human health are met.
Detailed Description
The following examples are given to facilitate a better understanding of the invention, but do not limit the invention. The experimental procedures in the following examples are conventional unless otherwise specified. The test materials used in the following examples are commercially available unless otherwise specified.
example 1
The invention relates to a Tibetan medicine composition for treating yak gastroenteritis, which comprises the following components:
200g of polygonum divaricatum, 180g of gentiana ussuriensis maxim, 180g of celery, 180g of cumin celery, 160g of clematis glauca and 100g of pyrus ussuriensis maxim.
The preparation method of the Tibetan medicine composition for treating yak gastroenteritis comprises the following steps:
1) Weighing the medicinal components in parts by mass;
2) putting the medicinal composition weighed in the step 1) into a stainless steel barrel, adding 8 times of deionized water by mass, decocting, boiling, continuing to decoct for 1 hour, and pouring out the liquid medicine; adding 5 times of deionized water, decocting, boiling, decocting for 1 hr, and pouring out the medicinal liquid; mixing the two decoctions, diluting to 1000ml, filtering, stirring, packaging, and sterilizing to obtain oral liquid.
The oral liquid has a good treatment effect on the yak gastroenteritis, the cure rate is more than 80%, and the total effective rate is more than 90%. The invention will be further illustrated by the following specific application examples.
Example 2 use of a Tibetan medicinal composition of the invention and comparative experiment 1
1 materials and methods
1.1 test animals
Yak 100 with gastroenteritis in Rulgan county, Sichuan province.
1.2 medicine
Test drugs: a medicament of the invention;
Control drug: ciprofloxacin hydrochloride (produced by Dahua agricultural animal health products of Guangdong Co., Ltd.).
2. Test method
100 yaks suffering from gastroenteritis are divided into two groups at random, wherein each group has 50 heads, and are treated by test medicines and control medicines respectively. The test drug is orally administered at a dose of 200 ml each time, 2 times per day for 3 days. The control group is ciprofloxacin hydrochloride with the concentration of 2 mg/kg, and is injected intramuscularly for 2 times a day and continuously used for 3 days.
and (3) judging the curative effect: and (3) healing: through treatment, the diseased yaks are normal in spirit, the excrement is formed, the hardness and the softness are moderate, the color and the smell are normal, the clinical symptoms are completely disappeared, and the diseased yaks are recovered to be normal. The method has the following advantages: through treatment, the diseased yak has improved mental state, enhanced appetite, improved fecal characteristics and relieved clinical symptoms. And (4) invalidation: through treatment, the diseased yak has no improvement in spirit and appetite, and the feces has no improvement, the disease condition is aggravated or other medicines are used for treatment, and even the yak dies.
3. And (3) test results:
The total effective rate of the test medicine on the yak gastroenteritis is identical to that of the control medicine, and is 94%, but the cure rate of the test medicine is 86%, the cure rate of the control medicine is 82%, and the test group is higher than or equal to that of the control group. The medicine has better therapeutic effect on yak gastroenteritis, and the results are detailed in table 1.
TABLE 1 therapeutic effect of different drugs on diarrhea in yak calf
Example 3 use of a Tibetan medicinal composition of the invention and comparative experiment 2
1 materials and methods
1.1 test animals
100 yaks suffering from gastroenteritis in Maqu county of Gansu province.
1.2 medicine
Test drugs: a medicament of the invention;
Control drug: poplar flower oral liquid (produced by Nanjing elegant bioengineering Co., Ltd.).
2. test method
100 yaks suffering from gastroenteritis are divided into two groups at random, wherein each group has 50 heads, and are treated by test medicines and control medicines respectively. The test drug is orally administered at a dose of 200 ml each time, 2 times per day for 3 days. The control group is poplar flower oral liquid, 100ml each time, 2 times daily, and 3 days continuously.
And (3) judging the curative effect: and (3) healing: through treatment, the diseased yaks are normal in spirit, the excrement is formed, the hardness and the softness are moderate, the color and the smell are normal, the clinical symptoms are completely disappeared, and the diseased yaks are recovered to be normal. The method has the following advantages: through treatment, the diseased yak has improved mental state, enhanced appetite, improved fecal characteristics and relieved clinical symptoms. And (4) invalidation: through treatment, the diseased yak has no improvement in spirit and appetite, and the feces has no improvement, the disease condition is aggravated or other medicines are used for treatment, and even the yak dies.
3. And (3) test results:
Compared with the control group, the curative ratio and the effective rate of the test group are higher than those of the control group. The medicine has better therapeutic effect on yak gastroenteritis, and the results are detailed in table 2.
TABLE 2 therapeutic effect of different drugs on diarrhea in yak calf
。
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (4)
1. A Tibetan medicine composition for treating yak gastroenteritis is characterized in that: the traditional Chinese medicine comprises the following raw material medicines in parts by weight: 200 parts of polygonum divaricatum, 180 parts of gentiana ussuriensis, 180 parts of celery, 180 parts of cumin celery, 160 parts of clematis glauca and 100 parts of pyrus ussuriensis.
2. A process for preparing a Tibetan medicinal composition as claimed in claim 1, which comprises the steps of: mixing the raw materials, decocting in water for 1-3 times, mixing decoctions, filtering, sterilizing, and making into oral liquid.
3. The preparation method of the pharmaceutical composition for treating diarrhea in yak calves as claimed in claim 2, wherein 200 parts of polygonum divaricatum, 180 parts of gentiana unordeta, 180 parts of celery, 180 parts of cumin celery, 160 parts of clematis ganqing and 100 parts of pyrus ussuriensis are weighed, put into a stainless steel barrel, 8000ml of deionized water is added, decocted, boiled, continuously decocted for 1 hour, and the liquid medicine is poured out; adding 5000ml deionized water, decocting, boiling, decocting for 1 hr, pouring out the medicinal liquid, mixing the two decoctions, diluting to 1000ml, filtering, stirring, packaging, and sterilizing to obtain oral liquid.
4. The use of a Tibetan medicinal composition of claim 1 in the preparation of a medicament for the treatment of yak gastroenteritis.
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| CN201610050423.3A CN105560444B (en) | 2016-01-26 | 2016-01-26 | Tibetan medicine composition for treating yak gastroenteritis and preparation method and application thereof |
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| CN105560444B true CN105560444B (en) | 2019-12-17 |
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| CN107669982B (en) * | 2017-10-31 | 2021-03-30 | 中国农业科学院兰州畜牧与兽药研究所 | Tibetan medicine composition and preparation method and application thereof |
| CN107823536B (en) * | 2017-11-07 | 2021-02-09 | 西藏自治区农牧科学院畜牧兽医研究所 | Tibetan medicine composition for preventing and treating hemorrhagic septicemia caused by Pasteurella multocida and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751673A (en) * | 2014-01-22 | 2014-04-30 | 中国农业科学院兰州畜牧与兽药研究所 | Tibetan medicinal composition for treating diarrhea of yak calf |
| CN104056112A (en) * | 2014-07-13 | 2014-09-24 | 郑家园 | Medicament for treating ulcerative colitis |
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- 2016-01-26 CN CN201610050423.3A patent/CN105560444B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751673A (en) * | 2014-01-22 | 2014-04-30 | 中国农业科学院兰州畜牧与兽药研究所 | Tibetan medicinal composition for treating diarrhea of yak calf |
| CN104056112A (en) * | 2014-07-13 | 2014-09-24 | 郑家园 | Medicament for treating ulcerative colitis |
Non-Patent Citations (1)
| Title |
|---|
| 中国伞形科药用植物概要;袁昌齐;《中国中药杂志》;19860131;第11卷(第01期);5-9 * |
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