CN104056112A

CN104056112A - Medicament for treating ulcerative colitis

Info

Publication number: CN104056112A
Application number: CN201410330142.4A
Authority: CN
Inventors: 郑家园
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-07-13
Filing date: 2014-07-13
Publication date: 2014-09-24

Abstract

The invention discloses a medicament for treating ulcerative colitis. The medicament is prepared from the following traditional Chinese medicine materials in parts by weight: 30-50 parts of flowers of edgeworthia chrysantha, 10-20 parts of thorny elaeagnus leaves, 10-20 parts of humulus lupulus, 4-10 parts of iris tectorum maxim, 4-10 parts of sapindus, 4-10 parts of rhizoma panacis majoris, 2-6 parts of seville orange flowers, 2-6 parts of momordica grosvenori, 2-6 parts of gentiana urnula, 2-6 parts of Chinese olive, 2-6 parts of bamboo shavings, 2-6 parts of asarum, 2-6 parts of seeds of Chinese waxgourd, 2-6 parts of coptis chinensis, 1-3 parts of tinospora sinensis, 1-3 parts of sophora japonica and 1-3 parts of semen torreya. The medicament has the beneficial effects of good curative effect, short treatment course, small side effect, convenience in use and the like for ulcerative colitis.

Description

A kind of medicament for the treatment of ulcerative colitis

Technical field

The present invention relates to technical field of Chinese medicines, specifically refer to a kind of medicament for the treatment of ulcerative colitis.

Background technology

Ulcerative colitis claims again nonspecific ulcerative colitis, is a kind of rectum and colonic diseases.Primary disease is mainly in person between twenty and fifty, and in recent years, along with the change of people's dietary structure, living habit and rhythm of life, sickness rate has obvious ascendant trend.Clinical manifestation is the repeatedly diarrhoea of unknown cause every day, with having blood in stool or Mucous Stool and stomachache, is outbreak repeatedly more.The primary disease cause of disease is still not clear at present, and onset is slowly most, minority Acute onset.

Doctor trained in Western medicine mainly adopts the method for Drug therapy and operative treatment to the treatment of this disease, western medicine is taking oral as main, and the dose for oral use adopting due to the pathological changes of colon section far away is large, and curative effect is unsatisfactory, and easily causes more side reaction.Operative treatment wound is large, the more difficult acceptance of patient.

Herbal retention enema method in clinical use for many years, is a reasonable route of administration, is mainly the absorption by intestinal wall, can utilize the semi-transparent permeability of the membrane of intestinal wall to be rapidly absorbed, and causes the therapeutical effect of whole body.

At present, treat this sick coloclysis Chinese drugs agentia and have that therapeutic effect is poor, slow problem takes effect.

Summary of the invention

In order to make up the deficiencies in the prior art, the invention provides the medicament of a kind of good effect, short treating period, side effect treatment ulcerative colitis little, easy to use.Specifically be achieved by the following technical solution:

Treat a medicament for ulcerative colitis, made by the Chinese crude drug of following weight portion: 30 ~ 50 parts of flowers of Edgeworthia chrysantha Lindl, 10 ~ 20 parts of Folium Elaeagnves, 10 ~ 20 parts of Flos lupuli (Flos Humuli Lupuli)s, 4 ~ 10 parts of Rhizoma Belamcandaes, 4 ~ 10 parts of Fructus Sapindi Mukouossis, 4 ~ 10 parts of Rhizoma Panacis Majoris, 2 ~ 6 parts of CitrusaurantiumL.Var.amara Engl.s, 2 ~ 6 parts of Fructus Momordicaes, 2 ~ 6 parts of Herba Gentianae Urnulaes, 2 ~ 6 parts of Fructus Canariis, 2 ~ 6 parts of Caulis Bambusae In Taenia, 2 ~ 6 parts of Herba Asaris, 2 ~ 6 parts of Semen Benincasaes, 2 ~ 6 parts of Rhizoma Coptidis, 1 ~ 3 part of Herba Lycopodii, 1 ~ 3 part of the Flos Sophorae Immaturus, 1 ~ 3 part of Semen Torreyae.

Preferably, treat a medicament for ulcerative colitis, made by the Chinese crude drug of following weight portion: 40 parts of flowers of Edgeworthia chrysantha Lindl, 15 parts of Folium Elaeagnves, 15 parts of Flos lupuli (Flos Humuli Lupuli)s, 7 parts of Rhizoma Belamcandaes, 7 parts of Fructus Sapindi Mukouossis, 7 parts of Rhizoma Panacis Majoris, 4 parts of CitrusaurantiumL.Var.amara Engl.s, 4 parts of Fructus Momordicaes, 4 parts of Herba Gentianae Urnulaes, 4 parts of Fructus Canariis, 4 parts of Caulis Bambusae In Taenia, 4 parts of Herba Asaris, 4 parts of Semen Benincasaes, 4 parts of Rhizoma Coptidis, 2 parts of Herba Lycopodii, 2 parts of the Flos Sophorae Immaturus, 2 parts of Semen Torreyaes.

The preparation method of the medicament of above-mentioned treatment ulcerative colitis is: the Chinese crude drug that takes described weight portion is put into drug-decocting appliance, adds clean water 1000 weight portions that meet drinking water standard; Enter to decoct front immersion half an hour, make it fully moistening, fully fried in order to medicine juice; After boiling with high heat, use slow fire boiling half an hour instead, cooled and filtered is removed medicinal residues again, taking liquid and get final product.

The Therapeutic Method of the medicament for the treatment of ulcerative colitis of the present invention: before sleeping every night, after emptying stool, urine, get right arm reclining, make buttocks shift near edge of bed, by intravenous transfusion methods, connect transfusion device, Exhaust Gas, transfusion device cuts off syringe needle, and end is coated a small amount of lubricating oil, insert rectum 10cm left and right from anus slowly, medicinal liquid is slowly splashed into.Fluid temperature is advisable with 37 DEG C of left and right, and pressure is low, and liquid level must not exceed 30cm apart from anus, after having filled with, lies up as far as possible.Coloclysis 1 time before sleeping every night, each about 50ml, 1 month is 1 course for the treatment of, can fully recover general 2 courses for the treatment of.

The medicament for the treatment of ulcerative colitis of the present invention, its beneficial effect is: have the advantages such as good effect, short treating period, side effect be little, easy to use for ulcerative colitis.

detailed description of the invention:

Below in conjunction with embodiment and case, the present invention is further illustrated.

Embodiment 1:

Take flowers of Edgeworthia chrysantha Lindl 30g, Folium Elaeagni 20g, Flos lupuli (Flos Humuli Lupuli) 10g, Rhizoma Belamcandae 10g, Fructus Sapindi Mukouossi 4g, Rhizoma Panacis Majoris 10g, CitrusaurantiumL.Var.amara Engl. 2g, Fructus Momordicae 6g, Herba Gentianae Urnulae 2g, Fructus Canarii 6g, Caulis Bambusae In Taenia 2g, Herba Asari 6g, Semen Benincasae 2g, Rhizoma Coptidis 6g, Herba Lycopodii 1g, Flos Sophorae Immaturus 3g, Semen Torreyae 1g puts into drug-decocting appliance, adds the clean water 1000g that meets drinking water standard; Enter to decoct front immersion half an hour, make it fully moistening, fully fried in order to medicine juice; After boiling with high heat, use slow fire boiling half an hour instead, cooled and filtered is removed medicinal residues again, and taking liquid obtains the medicament for the treatment of ulcerative colitis.

Embodiment 2:

Take flowers of Edgeworthia chrysantha Lindl 50g, Folium Elaeagni 10g, Flos lupuli (Flos Humuli Lupuli) 20g, Rhizoma Belamcandae 4g, Fructus Sapindi Mukouossi 10g, Rhizoma Panacis Majoris 4g, CitrusaurantiumL.Var.amara Engl. 6g, Fructus Momordicae 2g, Herba Gentianae Urnulae 6g, Fructus Canarii 2g, Caulis Bambusae In Taenia 6g, Herba Asari 2g, Semen Benincasae 6g, Rhizoma Coptidis 2g, Herba Lycopodii 3g, Flos Sophorae Immaturus 1g, Semen Torreyae 3g puts into drug-decocting appliance, adds the clean water 1000g that meets drinking water standard; Enter to decoct front immersion half an hour, make it fully moistening, fully fried in order to medicine juice; After boiling with high heat, use slow fire boiling half an hour instead, cooled and filtered is removed medicinal residues again, and taking liquid obtains the medicament for the treatment of ulcerative colitis.

Embodiment 3:

Take flowers of Edgeworthia chrysantha Lindl 40g, Folium Elaeagni 15g, Flos lupuli (Flos Humuli Lupuli) 15g, Rhizoma Belamcandae 7g, Fructus Sapindi Mukouossi 7g, Rhizoma Panacis Majoris 7g, CitrusaurantiumL.Var.amara Engl. 4g, Fructus Momordicae 4g, Herba Gentianae Urnulae 4g, Fructus Canarii 4g, Caulis Bambusae In Taenia 4g, Herba Asari 4g, Semen Benincasae 4g, Rhizoma Coptidis 4g, Herba Lycopodii 2g, Flos Sophorae Immaturus 2g, Semen Torreyae 2g puts into drug-decocting appliance, adds the clean water 1000g that meets drinking water standard; Enter to decoct front immersion half an hour, make it fully moistening, fully fried in order to medicine juice; After boiling with high heat, use slow fire boiling half an hour instead, cooled and filtered is removed medicinal residues again, and taking liquid obtains the medicament for the treatment of ulcerative colitis.

Clinical testing data of the present invention:

During in March, 2012 ~ 2013 year March, choose Ma ' anshan City patients of ulcerative colitis 129 examples, wherein male's 66 examples, women's 63 examples, 20 ~ 61 years old age, 38 years old mean age.Diagnostic criteria: the mucus hemafecia that 1, has persistence or repeatedly show effect, stomachache, with General Symptoms in various degree.2, the multiple fester of the visible mucosa of colonoscope companion congestion and edema, pathological changes mostly from rectum, and is diffusivity and distributes; The coarse fine particulate that is of mucosa, mucosa blood vessel is fuzzy, crisp, easily hemorrhage or with purulent secretion; Visible false polyp, haustra of colon is rust or disappearance often.3, get rid of the diseases such as the infectious colitis such as bacillary dysentery, ameba, schistosomicide, tuberculosis of intestine and Crohn disease, ischemic colitis, radiation colitis.

By random this 129 routine patient, be equally divided into three treatment groups, every group of 43 examples.Wherein, treatment group 1 adopts the pharmaceutical treatment of the embodiment of the present invention 1; Treatment group 2 adopts the pharmaceutical treatment of the embodiment of the present invention 2; Treatment group 3 adopts the pharmaceutical treatment of the embodiment of the present invention 3.

Therapeutic Method: before sleeping every night, after emptying stool, urine, get right arm reclining, make buttocks shift near edge of bed, press intravenous transfusion methods, connect transfusion device, Exhaust Gas, transfusion device cuts off syringe needle, end is coated a small amount of lubricating oil, inserts rectum 10cm left and right slowly from anus, and medicinal liquid is slowly splashed into.Fluid temperature is advisable with 37 DEG C of left and right, and pressure is low, and liquid level must not exceed 30cm apart from anus, after having filled with, lies up as far as possible.Coloclysis 1 time before sleeping every night, each about 50ml, treats 2 months continuously.Greasy, the pungent product of all avoiding eating anything raw or cold during treating, taboo is drunk.

Efficacy assessment standard:

Cure: clinical symptom disappearance, colonoscope check mucosa is normal, and drug withdrawal is observed 6 months without recurrence;

Effective: clinical symptoms substantially disappears or alleviates, only slight pathological changes of intestinal mirror check mucosa;

Invalid: clinical symptoms and mucosa pathological changes are without improvement.

Therapeutic outcome is in table 1:

Table 1 therapeutic outcome

Conclusion:

In clinical trial process, patient finds no any untoward reaction.Before and after treatment, routine blood test of each measurement, liver, renal function, every all normal before and after the treatment of result treatment group, and therefore, medicament of the present invention uses safety.Total effective rate to ulcerative colitis reaches 100%, and wherein the medicament of embodiment 3 is best to the curative effect of ulcerative colitis, cure rate reaches 97.7%, is the active drug for the treatment of ulcerative colitis, has well clinical and dissemination.

The above, be only preferred embodiment of the present invention, is not intended to limit protection scope of the present invention.One skilled in the art will appreciate that protection scope of the present invention is as the criterion with appending claims.

Claims

1. treat the medicament of ulcerative colitis for one kind, it is characterized in that, made by the Chinese crude drug of following weight portion: 30 ~ 50 parts of flowers of Edgeworthia chrysantha Lindl, 10 ~ 20 parts of Folium Elaeagnves, 10 ~ 20 parts of Flos lupuli (Flos Humuli Lupuli)s, 4 ~ 10 parts of Rhizoma Belamcandaes, 4 ~ 10 parts of Fructus Sapindi Mukouossis, 4 ~ 10 parts of Rhizoma Panacis Majoris, 2 ~ 6 parts of CitrusaurantiumL.Var.amara Engl.s, 2 ~ 6 parts of Fructus Momordicaes, 2 ~ 6 parts of Herba Gentianae Urnulaes, 2 ~ 6 parts of Fructus Canariis, 2 ~ 6 parts of Caulis Bambusae In Taenia, 2 ~ 6 parts of Herba Asaris, 2 ~ 6 parts of Semen Benincasaes, 2 ~ 6 parts of Rhizoma Coptidis, 1 ~ 3 part of Herba Lycopodii, 1 ~ 3 part of the Flos Sophorae Immaturus, 1 ~ 3 part of Semen Torreyae; Preparation method is: the Chinese crude drug that takes described weight portion is put into drug-decocting appliance, adds clean water 1000 weight portions that meet drinking water standard; Enter to decoct front immersion half an hour, make it fully moistening, fully fried in order to medicine juice; After boiling with high heat, use slow fire boiling half an hour instead, cooled and filtered is removed medicinal residues again, taking liquid and get final product.

2. a kind of medicament for the treatment of ulcerative colitis according to claim 1, it is characterized in that, made by the Chinese crude drug of following weight portion: 40 parts of flowers of Edgeworthia chrysantha Lindl, 15 parts of Folium Elaeagnves, 15 parts of Flos lupuli (Flos Humuli Lupuli)s, 7 parts of Rhizoma Belamcandaes, 7 parts of Fructus Sapindi Mukouossis, 7 parts of Rhizoma Panacis Majoris, 4 parts of CitrusaurantiumL.Var.amara Engl.s, 4 parts of Fructus Momordicaes, 4 parts of Herba Gentianae Urnulaes, 4 parts of Fructus Canariis, 4 parts of Caulis Bambusae In Taenia, 4 parts of Herba Asaris, 4 parts of Semen Benincasaes, 4 parts of Rhizoma Coptidis, 2 parts of Herba Lycopodii, 2 parts of the Flos Sophorae Immaturus, 2 parts of Semen Torreyaes.