CN104069465A - Agent for treating ulcerative colitis - Google Patents
Agent for treating ulcerative colitis Download PDFInfo
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- CN104069465A CN104069465A CN201410330134.XA CN201410330134A CN104069465A CN 104069465 A CN104069465 A CN 104069465A CN 201410330134 A CN201410330134 A CN 201410330134A CN 104069465 A CN104069465 A CN 104069465A
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Abstract
The invention discloses an agent for treating ulcerative colitis. The agent is prepared from the following traditional Chinese medicinal materials in parts by weight: 10-20 parts of Matteuccia Fern Rhizome, 5-10 parts of rhizoma cibotii, 5-10 parts of stigma croci, 5-10 parts of Radix Echinopsis, 5-10 parts of camphorwood, 5-10 parts of Fistular Onion Seed, 4-10 parts of wintersweet flower, 4-10 parts of negundo chastetree fruit, 4-10 parts of burdock, 4-10 parts of flos farfarae, 4-10 parts of Platycodon grandiflorum, 3-7 parts of Pogostemon cablin, 3-7 parts of fresh ginger, 3-7 parts of isatis root, 3-7 parts of cortex albiziae, 3-7 parts of Juncus roemerianus, 3-7 parts of concha arcae and 3-7 parts of Lysimachia christinae Hance. The agent has the beneficial effects that the agent has the advantages of good curative effect on treatment of ulcerative colitis, as well as short course of treatment, small side effect, convenience in use and the like.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically refer to a kind of medicament for the treatment of ulcerative colitis.
Background technology
Ulcerative colitis claims again nonspecific ulcerative colitis, is a kind of rectum and colonic diseases.Primary disease is mainly in person between twenty and fifty, and in recent years, along with the change of people's dietary structure, living habit and rhythm of life, sickness rate has obvious ascendant trend.Clinical manifestation is the repeatedly diarrhoea of unknown cause every day, with having blood in stool or Mucous Stool and stomachache, is outbreak repeatedly more.The primary disease cause of disease is still not clear at present, and onset is slowly most, minority Acute onset.
Doctor trained in Western medicine mainly adopts the method for Drug therapy and operative treatment to the treatment of this disease, western medicine is taking oral as main, and the dose for oral use adopting due to the pathological changes of colon section far away is large, and curative effect is unsatisfactory, and easily causes more side reaction.Operative treatment wound is large, the more difficult acceptance of patient.
Herbal retention enema method in clinical use for many years, is a reasonable route of administration, is mainly the absorption by intestinal wall, can utilize the semi-transparent permeability of the membrane of intestinal wall to be rapidly absorbed, and causes the therapeutical effect of whole body.
At present, treat this sick coloclysis Chinese drugs agentia and have that therapeutic effect is poor, slow problem takes effect.
Summary of the invention
In order to make up the deficiencies in the prior art, the invention provides the medicament of a kind of good effect, short treating period, side effect treatment ulcerative colitis little, easy to use.Specifically be achieved by the following technical solution:
Treat a medicament for ulcerative colitis, made by the Chinese crude drug of following weight portion: 10 ~ 20 parts of Matteuccia Fern Rhizomes, 5 ~ 10 parts of Rhizoma Cibotii, 5 ~ 10 parts of Stigma Crocis, 5 ~ 10 parts of Radix Echinopsiss, 5 ~ 10 parts of Lignum cinnamomi camphoraes, 5 ~ 10 parts of Herba Alii fistulosis, 4 ~ 10 parts of Flos Mume, 4 ~ 10 parts of Fructus Viticis Negundo, 4 ~ 10 parts of Fructus Arctiis, 4 ~ 10 parts of Flos Farfaraees, 4 ~ 10 parts of Radix Platycodoniss, 3 ~ 7 parts of Herba Pogostemonis, 3 ~ 7 parts, Rhizoma Zingiberis Recens, 3 ~ 7 parts of Radix Isatidis, 3 ~ 7 parts of Cortex Albiziaes, 3 ~ 7 parts of Medulla Juncies, 3 ~ 7 parts of Concha Arcaes, 3 ~ 7 parts of Herba Lysimachiaes.
Preferably, treat a medicament for ulcerative colitis, made by the Chinese crude drug of following weight portion: 15 parts of Matteuccia Fern Rhizomes, 8 parts of Rhizoma Cibotii, 8 parts of Stigma Crocis, 7 parts of Radix Echinopsiss, 7 parts of Lignum cinnamomi camphoraes, 7 parts of Herba Alii fistulosis, 7 parts of Flos Mume, 7 parts of Fructus Viticis Negundo, 7 parts of Fructus Arctiis, 7 parts of Flos Farfaraees, 7 parts of Radix Platycodoniss, 5 parts of Herba Pogostemonis, 5 parts, Rhizoma Zingiberis Recens, 5 parts of Radix Isatidis, 5 parts of Cortex Albiziaes, 5 parts of Medulla Juncies, 5 parts of Concha Arcaes, 5 parts of Herba Lysimachiaes.
The preparation method of the medicament of above-mentioned treatment ulcerative colitis is: the Chinese crude drug that takes described weight portion is put into drug-decocting appliance, adds clean water 1000 weight portions that meet drinking water standard; Enter to decoct front immersion half an hour, make it fully moistening, fully fried in order to medicine juice; After boiling with high heat, use slow fire boiling half an hour instead, cooled and filtered is removed medicinal residues again, taking liquid and get final product.
The Therapeutic Method of the medicament for the treatment of ulcerative colitis of the present invention: before sleeping every night, after emptying stool, urine, get right arm reclining, make buttocks shift near edge of bed, by intravenous transfusion methods, connect transfusion device, Exhaust Gas, transfusion device cuts off syringe needle, and end is coated a small amount of lubricating oil, insert rectum 10cm left and right from anus slowly, medicinal liquid is slowly splashed into.Fluid temperature is advisable with 37 DEG C of left and right, and pressure is low, and liquid level must not exceed 30cm apart from anus, after having filled with, lies up as far as possible.Coloclysis 1 time before sleeping every night, each about 50ml, 1 month is 1 course for the treatment of, can fully recover general 2 courses for the treatment of.
The medicament for the treatment of ulcerative colitis of the present invention, its beneficial effect is: have the advantages such as good effect, short treating period, side effect be little, easy to use for ulcerative colitis.
detailed description of the invention:
Below in conjunction with embodiment and case, the present invention is further illustrated.
Embodiment 1:
Take Matteuccia Fern Rhizome 10g, Rhizoma Cibotii 10g, Stigma Croci 5g, Radix Echinopsis 10g, Lignum cinnamomi camphorae 5g, Herba Alii fistulosi 10g, Flos Mume 4g, Fructus Viticis Negundo 10g, Fructus Arctii 4g, Flos Farfarae 10g, Radix Platycodonis 4g, Herba Pogostemonis 7g, Rhizoma Zingiberis Recens 3g, Radix Isatidis 7g, Cortex Albiziae 3g, Medulla Junci 7g, Concha Arcae 3g, Herba Lysimachiae 7g put into drug-decocting appliance, add the clean water 1000g that meets drinking water standard; Enter to decoct front immersion half an hour, make it fully moistening, fully fried in order to medicine juice; After boiling with high heat, use slow fire boiling half an hour instead, cooled and filtered is removed medicinal residues again, and taking liquid obtains the medicament for the treatment of ulcerative colitis.
Embodiment 2:
Take Matteuccia Fern Rhizome 20g, Rhizoma Cibotii 5g, Stigma Croci 10g, Radix Echinopsis 5g, Lignum cinnamomi camphorae 10g, Herba Alii fistulosi 5g, Flos Mume 10g, Fructus Viticis Negundo 4g, Fructus Arctii 10g, Flos Farfarae 4g, Radix Platycodonis 10g, Herba Pogostemonis 3g, Rhizoma Zingiberis Recens 7g, Radix Isatidis 3g, Cortex Albiziae 7g, Medulla Junci 3g, Concha Arcae 7g, Herba Lysimachiae 3g put into drug-decocting appliance, add the clean water 1000g that meets drinking water standard; Enter to decoct front immersion half an hour, make it fully moistening, fully fried in order to medicine juice; After boiling with high heat, use slow fire boiling half an hour instead, cooled and filtered is removed medicinal residues again, and taking liquid obtains the medicament for the treatment of ulcerative colitis.
Embodiment 3:
Take Matteuccia Fern Rhizome 15g, Rhizoma Cibotii 8g, Stigma Croci 8g, Radix Echinopsis 7g, Lignum cinnamomi camphorae 7g, Herba Alii fistulosi 7g, Flos Mume 7g, Fructus Viticis Negundo 7g, Fructus Arctii 7g, Flos Farfarae 7g, Radix Platycodonis 7g, Herba Pogostemonis 5g, Rhizoma Zingiberis Recens 5g, Radix Isatidis 5g, Cortex Albiziae 5g, Medulla Junci 5g, Concha Arcae 5g, Herba Lysimachiae 5g put into drug-decocting appliance, add the clean water 1000g that meets drinking water standard; Enter to decoct front immersion half an hour, make it fully moistening, fully fried in order to medicine juice; After boiling with high heat, use slow fire boiling half an hour instead, cooled and filtered is removed medicinal residues again, and taking liquid obtains the medicament for the treatment of ulcerative colitis.
Clinical testing data of the present invention:
During in March, 2012 ~ 2013 year March, choose Hefei City, Anhui Province patients of ulcerative colitis 195 examples, wherein male's 94 examples, women's 101 examples, 18 ~ 67 years old age, 42 years old mean age.Diagnostic criteria: the mucus hemafecia that 1, has persistence or repeatedly show effect, stomachache, with General Symptoms in various degree.2, the multiple fester of the visible mucosa of colonoscope companion congestion and edema, pathological changes mostly from rectum, and is diffusivity and distributes; The coarse fine particulate that is of mucosa, mucosa blood vessel is fuzzy, crisp, easily hemorrhage or with purulent secretion; Visible false polyp, haustra of colon is rust or disappearance often.3, get rid of the diseases such as the infectious colitis such as bacillary dysentery, ameba, schistosomicide, tuberculosis of intestine and Crohn disease, ischemic colitis, radiation colitis.
By random this 195 routine patient, be equally divided into three treatment groups, every group of 65 examples.Wherein, treatment group 1 adopts the pharmaceutical treatment of the embodiment of the present invention 1; Treatment group 2 adopts the pharmaceutical treatment of the embodiment of the present invention 2; Treatment group 3 adopts the pharmaceutical treatment of the embodiment of the present invention 3.
Therapeutic Method: before sleeping every night, after emptying stool, urine, get right arm reclining, make buttocks shift near edge of bed, press intravenous transfusion methods, connect transfusion device, Exhaust Gas, transfusion device cuts off syringe needle, end is coated a small amount of lubricating oil, inserts rectum 10cm left and right slowly from anus, and medicinal liquid is slowly splashed into.Fluid temperature is advisable with 37 DEG C of left and right, and pressure is low, and liquid level must not exceed 30cm apart from anus, after having filled with, lies up as far as possible.Coloclysis 1 time before sleeping every night, each about 50ml, treats 2 months continuously.Greasy, the pungent product of all avoiding eating anything raw or cold during treating, taboo is drunk.
Efficacy assessment standard:
Cure: clinical symptom disappearance, colonoscope check mucosa is normal, and drug withdrawal is observed 6 months without recurrence;
Effective: clinical symptoms substantially disappears or alleviates, only slight pathological changes of intestinal mirror check mucosa;
Invalid: clinical symptoms and mucosa pathological changes are without improvement.
Therapeutic outcome is in table 1:
Table 1 therapeutic outcome
Conclusion:
In clinical trial process, patient finds no any untoward reaction.Before and after treatment, routine blood test of each measurement, liver, renal function, every all normal before and after the treatment of result treatment group, and therefore, medicament of the present invention uses safety.Total effective rate to ulcerative colitis reaches 100%, and wherein the medicament of embodiment 3 is best to the curative effect of ulcerative colitis, cure rate reaches 93.8%, is the active drug for the treatment of ulcerative colitis, has well clinical and dissemination.
The above, be only preferred embodiment of the present invention, is not intended to limit protection scope of the present invention.One skilled in the art will appreciate that protection scope of the present invention is as the criterion with appending claims.
Claims (2)
1. treat the medicament of ulcerative colitis for one kind, it is characterized in that, made by the Chinese crude drug of following weight portion: 10 ~ 20 parts of Matteuccia Fern Rhizomes, 5 ~ 10 parts of Rhizoma Cibotii, 5 ~ 10 parts of Stigma Crocis, 5 ~ 10 parts of Radix Echinopsiss, 5 ~ 10 parts of Lignum cinnamomi camphoraes, 5 ~ 10 parts of Herba Alii fistulosis, 4 ~ 10 parts of Flos Mume, 4 ~ 10 parts of Fructus Viticis Negundo, 4 ~ 10 parts of Fructus Arctiis, 4 ~ 10 parts of Flos Farfaraees, 4 ~ 10 parts of Radix Platycodoniss, 3 ~ 7 parts of Herba Pogostemonis, 3 ~ 7 parts, Rhizoma Zingiberis Recens, 3 ~ 7 parts of Radix Isatidis, 3 ~ 7 parts of Cortex Albiziaes, 3 ~ 7 parts of Medulla Juncies, 3 ~ 7 parts of Concha Arcaes, 3 ~ 7 parts of Herba Lysimachiaes; Preparation method is: the Chinese crude drug that takes described weight portion is put into drug-decocting appliance, adds clean water 1000 weight portions that meet drinking water standard; Enter to decoct front immersion half an hour, make it fully moistening, fully fried in order to medicine juice; After boiling with high heat, use slow fire boiling half an hour instead, cooled and filtered is removed medicinal residues again, taking liquid and get final product.
2. a kind of medicament for the treatment of ulcerative colitis according to claim 1, it is characterized in that, made by the Chinese crude drug of following weight portion: 15 parts of Matteuccia Fern Rhizomes, 8 parts of Rhizoma Cibotii, 8 parts of Stigma Crocis, 7 parts of Radix Echinopsiss, 7 parts of Lignum cinnamomi camphoraes, 7 parts of Herba Alii fistulosis, 7 parts of Flos Mume, 7 parts of Fructus Viticis Negundo, 7 parts of Fructus Arctiis, 7 parts of Flos Farfaraees, 7 parts of Radix Platycodoniss, 5 parts of Herba Pogostemonis, 5 parts, Rhizoma Zingiberis Recens, 5 parts of Radix Isatidis, 5 parts of Cortex Albiziaes, 5 parts of Medulla Juncies, 5 parts of Concha Arcaes, 5 parts of Herba Lysimachiaes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410330134.XA CN104069465A (en) | 2014-07-13 | 2014-07-13 | Agent for treating ulcerative colitis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410330134.XA CN104069465A (en) | 2014-07-13 | 2014-07-13 | Agent for treating ulcerative colitis |
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| Publication Number | Publication Date |
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| CN104069465A true CN104069465A (en) | 2014-10-01 |
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| CN201410330134.XA Withdrawn CN104069465A (en) | 2014-07-13 | 2014-07-13 | Agent for treating ulcerative colitis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022109092A1 (en) * | 2020-11-18 | 2022-05-27 | Howard University | Saffron as anti-inflammatory agent in treating inflammatory bowel disease |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102258583A (en) * | 2011-06-24 | 2011-11-30 | 重庆赛诺生物药业股份有限公司 | Traditional Chinese medicine preparation for treating chronic and nonspecific ulcerative colitis and preparation method thereof |
| CN103705798A (en) * | 2013-12-10 | 2014-04-09 | 董崇林 | Traditional Chinese medicine for treating ulcerative colitis |
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2014
- 2014-07-13 CN CN201410330134.XA patent/CN104069465A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102258583A (en) * | 2011-06-24 | 2011-11-30 | 重庆赛诺生物药业股份有限公司 | Traditional Chinese medicine preparation for treating chronic and nonspecific ulcerative colitis and preparation method thereof |
| CN103705798A (en) * | 2013-12-10 | 2014-04-09 | 董崇林 | Traditional Chinese medicine for treating ulcerative colitis |
Non-Patent Citations (1)
| Title |
|---|
| 章文春等: "《中医学》", 30 June 2013, 人民军医出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022109092A1 (en) * | 2020-11-18 | 2022-05-27 | Howard University | Saffron as anti-inflammatory agent in treating inflammatory bowel disease |
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Application publication date: 20141001 |