CN102988631B - Chinese medicinal preparation for treating epilepsia - Google Patents
Chinese medicinal preparation for treating epilepsia Download PDFInfo
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- CN102988631B CN102988631B CN201210423104.4A CN201210423104A CN102988631B CN 102988631 B CN102988631 B CN 102988631B CN 201210423104 A CN201210423104 A CN 201210423104A CN 102988631 B CN102988631 B CN 102988631B
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Abstract
The invention relates to a Chinese medicinal preparation for treating epilepsia. The Chinese medicinal preparation is characterized by comprising the following Chinese medicinal herbs in parts by weight: 18-22 parts of bighead atractylodes rhizome, 18-22 parts of rhizome of Chinese goldthread, 2-5 parts of buthus martensi kirsch, 18-22 parts of fushen, 8-12 parts of magnolia officinalis, 8-12 parts of citri grandis, 8-12 parts of agilawood, 8-12 parts of rhizoma alismatis, 8-12 parts of caulis polygoni multiflori, 2-5 parts of medcinal evodia fruit and 3-7 parts of cassia seed. The Chinese medicinal preparation is a pure-Chinese medicine preparation, and the Chinese medicinal herbs are reasonably matched according to the principle of assistant and guide, and thus the Chinese medicinal preparation is capable of carrying out diagnosis and treatment based on an overall analysis of the illness and the patient's condition. The Chinese medicinal preparation has a remarkable curative effect on epilepsies such as phlegm stagnation, heart-spleen deficiency, deficiency of liver-yin and kidney-yin and liver wind phlegm obstruction, and is high in curative rate and low in cost.
Description
Technical field
The present invention relates to the field of Chinese medicines, is a kind of Chinese medicine preparation for the treatment of epilepsy, is mainly used in epilepsy phase and convalescent treatment.
Background technology
Epilepsy, it is commonly called as " sheep is insane crazy ", " epilepsy " or " epilepsy ", is a kind of brain disorder, take brain neuroblastoma unit repeatedly suddenly the intermittent central nervous system function due to over-discharge lack of proper care as feature.That one originates from brain, and sensation of movement, autonomic nerve, consciousness and the mental status of outbreak repeatedly obstacle in various degree.Be characterized in that sustainable existence can produce the brain persistency change of epilepsy, and occur the consequence of corresponding Shen through aspects such as Sheng Wu ﹑ Ren Zhi ﹑ psychology and sociology.Be diagnosed as epilepsy and at least need epilepsy one time.But, up to now, the common recognition of domestic educational circles be recurrent epilepsy just diagnosable be epilepsy, if only once outbreak just should not be diagnosed as epilepsy.
Chinese medicine theory thinks that the former of epilepsy is because incoordination of seven emotions; Congenital factors; Brain wound; Eating and drinking without temperance; Overwork.Sick position and relate to internal organs: sick position, at brain, relates to the heart, liver,spleen,kidney.
Traditional Chinese Medicine treatment epilepsy is paid attention to determination of cause of disease according to differentiation of symptoms and signs, is examined because discussing and control.Not " not making epilepsy without expectorant " that ancients often say, expectorant is a kind of presentation, also will investigate the material elements that produces expectorant, and its pathogenesis is the turbid inner product of expectorant, and stagnation of Qi and phelgm, disturbs in wind sun, covers and closes thinking, alters stagnant meridians.No matter be Secondary cases or constitutional, control with Chinese medicine conditioning that it is basic, the function of conditioning imbalance, makes yin-Yang, the internal organs state that tends to balance.
Along with the quickening of social development rhythm and the increase of life stress, the quantity that causes more youngster to suffer from epilepsy disease is increasing year by year, brings white elephant also to a lot of families at present, and we especially pay attention to just exploitation of the research of epilepsy for this reason.At present the treatment of epilepsy is main mainly with Western medicine, as phenytoin Sodium, carbamazepine, valproic acid that, appropriate Thailand etc.But these medicines need long-term taking, can only control from surface and suppress the state of an illness, run in emotion and have any fluctuation all likely to cause disease relapse.And taking these medicines has larger side effect throughout the year, produce dependency, occur depressed, even depression and suicide tendency of the hypophrenia.In addition, the neurosurgery of large hospital is carried out the operation of opening cranium treatment of epilepsy now, but has a big risk, and surgical injury is larger.Discharge position shifts and can not cure completely.In the time that medicine does not have obvious effect to the state of an illness, some epileptics just can adopt operative treatment, and brain cortex focus is excised, and directly excise epileptic focus or blocking-up pathway by operation of opening cranium.If but there is no professional instrument, can not check out accurately the accurate location of focus, even if moved operation of opening cranium, can not fully and completely excise electric discharge nervous tissue, postoperative craniocerebral injury causes aggravation.
Summary of the invention
The object of the invention is, provide a kind of evident in efficacy, cure rate is high, the Chinese medicine preparation of the treatment epilepsy that cost is low.
Realizing the technical solution adopted in the present invention is: a kind of Chinese medicine preparation for the treatment of epilepsy, is characterized in that: the crude drug that it comprises following weight parts: 18～22 parts of the Rhizoma Atractylodis Macrocephalaes, 18～22 parts of Rhizoma Coptidis, 2～5 parts of Scorpios, 18～22 parts of Poria cum Radix Pinis, 8～12 parts of Cortex Magnoliae Officinalis, 8～12 parts of Exocarpium Citri Rubrums, 8～12 parts of Lignum Aquilariae Resinatum, 8～12 parts of Rhizoma Alismatis, 8～12 parts of Caulis Polygoni Multiflori, 2～5 parts of Fructus Evodiaes, 3～7 parts of Semen Cassiaes.
Further, the crude drug that comprises following weight parts: 19～21 parts of the Rhizoma Atractylodis Macrocephalaes, 19～21 parts of Rhizoma Coptidis, 3～4 parts of Scorpios, 19～21 parts of Poria cum Radix Pinis, 9～11 parts of Cortex Magnoliae Officinalis, 9～11 parts of Exocarpium Citri Rubrums, 9～11 parts of Lignum Aquilariae Resinatum, 9～11 parts of Rhizoma Alismatis, 9～11 parts of Caulis Polygoni Multiflori, 3～4 parts of Fructus Evodiaes, 4～6 parts of Semen Cassiaes.
In crude drug of the present invention: Rhizoma Atractylodis Macrocephalae Largehead Atractylodes Rh.Bitter, sweet, temperature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic.
Rhizoma Coptidis Coptis chinensis Franch hardship, cold, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.
Scorpio SCORPIO, main medicinal ingredient is charybdotoxin (Buthotoxin), pungent, flat; Poisonous.Return Liver Channel.There is " spasmolytic that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., antiinflammatory counteracting toxic substances, removing obstruction in the collateral to relieve pain " function.
Poria cum Radix Pini is the sclerotium of the sleeping hole platymiscium Poria [(Poria cocos Schw.) Wolf] of Polyporaceae, and nature and flavor are sweet, light flat.There are the functions such as eliminating dampness by diuresis, spleen invigorating, mind calming.For phlegm retention, edema, dysuria.
Cortex Magnoliae Officinalis CORTEX MAGNOLIAE OFFICINALIS.Bitter in the mouth is pungent; Warm in nature.Return spleen channel, stomach warp, large intestine channel.Effect: circulation of qi promoting removing food stagnancy, dampness is removed full, lowering the adverse QI to relieve asthma.Cure mainly: stagnation of QI due to dyspepsia, abdominal distention constipation, retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea, and expectorant is stopped up QI rising in reverse order, and fullness in the chest is breathed with cough.
Exocarpium Citri Rubrum EXOCARPIUM CITRI RUBRUM, pungent, bitter, temperature.Return lung, spleen channel.Cure mainly: cold expelling, dampness, promoting the circulation of QI, expectorant.
Lignum Aquilariae Resinatum Chinese Eaglewood.Pungent, bitter, temperature.Return spleen, stomach, kidney, lung meridian.Sending down the abnormal ascending QI warming middle-JIAO, warming the kidney improving inspiration by invigorating kidney-QI.
Rhizoma Alismatis Rhizome of Oriental Waterplantain.Sweet in the mouth; Light; Cold in nature.Return kidney; Urinary bladder channel.Promoting diuresis to eliminate damp pathogen; Expel the heat-evil treating stranguria.
Caulis Polygoni Multiflori Tuber Fleeceflower Stem, sweet micro-hardship, flat.Effect: nourish heart, calm the nerves, dredging collateral, dispels the wind.
Lignum Aquilariae Resinatum Chinese Eaglewood, pungent, bitter, temperature.Return spleen, stomach, kidney, lung meridian, sending down the abnormal ascending QI warming middle-JIAO, warming the kidney improving inspiration by invigorating kidney-QI.
Fructus Evodiae Tetradium ruticarpum: bitter in the mouth is pungent, hot greatly, slightly poisonous.Enter liver, stomach warp.Function is clearing away liver-fire, stopping nausea and vomiting by lowering the adverse flow of QI.Warming middle-JIAO, pain relieving, regulates the flow of vital energy, dampness.
Semen Cassiae Semen Cassiae is sweet, bitter, salty, be slightly cold.Return liver, large intestine channel.Clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.
A kind of Chinese medicine preparation for the treatment of epilepsy of the present invention is pure Chinese medicinal preparation, and crude drug is according to monarch compatibility, and compatibility is reasonable, can determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.For mental disorder pent-up and deficiency of both the heart and spleen, the epilepsy such as liver-kidney yin deficiency and liver-wind phlegm stagnation syndrome type evident in efficacy, cure rate is high, and cost is low.
The specific embodiment
Below in conjunction with example, the invention will be further described:
The weight ratio that preparation the present invention treats the each crude drug of embodiment 1-5 of the Chinese medicine preparation of epilepsy sees the following form
Unit of weight: ㎏
| Row number | The Rhizoma Atractylodis Macrocephalae | Rhizoma Coptidis | Scorpio | Poria cum Radix Pini | Cortex Magnoliae Officinalis | Exocarpium Citri Rubrum | Lignum Aquilariae Resinatum | Rhizoma Alismatis | Caulis Polygoni Multiflori | Fructus Evodiae | Semen Cassiae |
| 1 | 18 | 18 | 2 | 18 | 8 | 8 | 8 | 8 | 8 | 2 | 3 |
| 2 | 19 | 19 | 2.75 | 19 | 9 | 9 | 9 | 9 | 9 | 2.75 | 4 |
| 3 | 20 | 20 | 3.5 | 20 | 10 | 10 | 10 | 10 | 10 | 3.5 | 5 |
| 4 | 21 | 21 | 4.25 | 21 | 11 | 11 | 11 | 11 | 11 | 4.25 | 6 |
| 5 | 22 | 22 | 5 | 22 | 12 | 12 | 12 | 12 | 12 | 5 | 7 |
The present invention's crude drug used should meet the regulation of 2000 " Chinese Pharmacopoeia ".
A kind of Chinese medicine preparation for the treatment of epilepsy of the present invention is prepared according to a conventional method, take embodiment 3 as example:
1. take by weight the Rhizoma Atractylodis Macrocephalae 20 ㎏, Rhizoma Coptidis 20 ㎏, Scorpio 3.5 ㎏, Poria cum Radix Pini 20 ㎏, Cortex Magnoliae Officinalis 10 ㎏, Exocarpium Citri Rubrum 10 ㎏, Lignum Aquilariae Resinatum 10 ㎏, Rhizoma Alismatis 10 ㎏, Caulis Polygoni Multiflori 10 ㎏, Fructus Evodiae 3.5 ㎏, Semen Cassiae 5 ㎏, use Chinese crude drug dry cleaner to carry out washing, Chinese crude drug dry cleaner washing crude drug can be avoided conventional washing and cause the effective elements of the medicine to run off and waste and the sewage discharge of water;
2. the each crude drug after dry cleaner washing is placed in hothouse, warp is lower than 75 ℃ of freeze-day with constant temperature processing;
3. be ground into 80～120 order fine powders with pulverizer;
4. in described fine powder, add water soluble excipient, with appropriate alcoholic strength be 60%(V/V) ethanol make soft material, as long as the soft or hard degree of soft material is suitable for selected comminutor granulation;
By described soft material through one-step method fluidization granulation machine granulation, be packaged into every pouch 5g after dry.
The present invention, except pressing the preparation method granulation agent of the present embodiment, also can be made into any dosage forms such as powder, capsule or pill.
Described Chinese crude drug dry cleaner is that commercially available XG series traditional Chinese material dry cleaner all can; Pulverizer is that commercially available hammer or Universalpulverizer all can; Comminutor is commercially available prod; Water soluble excipient and ethanol are the adjuvant that commercially available pharmaceutical field is conventional.
A kind of Chinese medicine preparation for the treatment of epilepsy of the present invention, during year June in June, 2008 to 2010, shows epilepsy sample spike to 156 routine electroencephalograms, is diagnosed as epileptic's clinical treatment observation, has obtained significant curative effect, and its total effective rate is 93.99%.
1. clinical data: amount to case 156 examples, wherein male 74 examples, female's 82 examples; Inclusion criteria is the epileptic that hospital makes a definite diagnosis, and electroencephalogram shows epilepsy sample spike.
2. Therapeutic Method and consumption: be 5g each serving a pouch content, three times on the one, early, middle and lately service once after meal, within 6～10 weeks, be a course for the treatment of, also take continuously 2 courses for the treatment of.
3. therapeutic evaluation: one the course for the treatment of period in a medicine, epilepsy disappears, electroencephalogram shows the radio fade-out of epilepsy sample, it is normal that electroencephalogram recovers, and do not show effect in two years for curing after drug withdrawal; Through taking medicine of 2 courses for the treatment of, epilepsy is obviously alleviated, and after drug withdrawal, recurrent number obviously reduces and recurrence interval prolongation, and electroencephalogram shows that epilepsy sample spike is reduced to effectively; After taking medicine 2 courses for the treatment of, epilepsy is without alleviation, and electroencephalogram shows epilepsy sample spike, still has outbreak.
4. therapeutic effect: in patient's 156 examples, cure 132 examples, effective 16 examples, invalid 8 examples, effective percentage 94.87%.
Model case
Case 1, the Qin, male, 48 years old, people from Jilin.Because " meningioma " operation of opening cranium 2 years, left limb paroxysmal is twitched, and the about 3-30 minute of each outbreak twitches.When medical, left limb and bicker have twitch, Consciousness, and EEG (electrocardiogram) examination right side frontal lobe has abnormal epilepsy spike.Oral " valproic acid that " 1 year, effect is variation gradually.Be diagnosed as focal seizure, dosage in accordance with regulations, takes Chinese medicine of the present invention 10 weeks, and symptom disappears completely, and electroencephalogram check epilepsy spike disappears.
Case 2, what certain, female, 17 years old, people from Shulan City.Before 5 years initial stage symptom be after waking up, there is soon myoclonus and the hands soon of getting up in the article taken independently do not drop suddenly.Episodes is of short duration, bilaterally symmetric, synchronous, arrhythmic muscle contraction.Clear consciousness when outbreak.Within nearly 2 years, there is generalized tonic-clonic seizure.Clinical diagnosis is: Lafora's disease.Take valproic acid that and phenytoin Sodium 2 years, because side effect is stopped using, change Chinese medicine of the present invention, dosage in accordance with regulations, takes 2 courses for the treatment of, and transference cure is followed up a case by regular visits to not recurrence in 2 years.
Case 3, Wang, women, 37 years old, people from Jilin.Emotional at ordinary times, angry.Because there is tic of the limbs repeatedly after quarreling with people, when outbreak, eyes are stared, and shout strangely, and sustainable several minutes, check right epilepsy sample electric discharge when electroencephalogram outbreak.Pulse condition stringy and rapid pulse when medical, red tongue, few tongue.Dosage in accordance with regulations, took medicine of the present invention after 6 weeks, and symptom alleviates, and 10 weeks transference cures are followed up a case by regular visits to not recurrence in 2 years.
The specific embodiment of the present invention is also non exhaustive, and those skilled in the art, without simple copy and the formula adjustment of creative work, should belong to the protection domain of the claims in the present invention.
Claims (2)
1. a Chinese medicine preparation for the treatment of epilepsy, is characterized in that: it is made up of the crude drug of following weight portion: 18～22 parts of the Rhizoma Atractylodis Macrocephalaes, 18～22 parts of Rhizoma Coptidis, 2～5 parts of Scorpios, 18～22 parts of Poria cum Radix Pinis, 8～12 parts of Cortex Magnoliae Officinalis, 8～12 parts of Exocarpium Citri Rubrums, 8～12 parts of Lignum Aquilariae Resinatum, 8～12 parts of Rhizoma Alismatis, 8～12 parts of Caulis Polygoni Multiflori, 2～5 parts of Fructus Evodiaes, 3～7 parts of Semen Cassiaes.
2. a kind of Chinese medicine preparation for the treatment of epilepsy according to claim 1, is characterized in that: it is made up of the crude drug of following weight portion: 19～21 parts of the Rhizoma Atractylodis Macrocephalaes, 19～21 parts of Rhizoma Coptidis, 3～4 parts of Scorpios, 19～21 parts of Poria cum Radix Pinis, 9～11 parts of Cortex Magnoliae Officinalis, 9～11 parts of Exocarpium Citri Rubrums, 9～11 parts of Lignum Aquilariae Resinatum, 9～11 parts of Rhizoma Alismatis, 9～11 parts of Caulis Polygoni Multiflori, 3～4 parts of Fructus Evodiaes, 4～6 parts of Semen Cassiaes.
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| CN201210423104.4A CN102988631B (en) | 2012-10-30 | 2012-10-30 | Chinese medicinal preparation for treating epilepsia |
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| CN201210423104.4A CN102988631B (en) | 2012-10-30 | 2012-10-30 | Chinese medicinal preparation for treating epilepsia |
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| CN103285212B (en) * | 2013-05-29 | 2014-09-17 | 王智霞 | Traditional Chinese medicine preparation for treating pediatric epilepsy and preparation method thereof |
| CN105497399A (en) * | 2016-01-22 | 2016-04-20 | 王丹旎 | Traditional Chinese medicine preparation for treating phlegm-qi stagnation type depressive psychosis and preparation method and application thereof |
| CN105920242A (en) * | 2016-06-28 | 2016-09-07 | 唐冬香 | Traditional Chinese medicine for treating phlegm depression |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102366555A (en) * | 2011-10-23 | 2012-03-07 | 徐天英 | Chinese medicine prescription for treating epilepsy |
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| CN102366555A (en) * | 2011-10-23 | 2012-03-07 | 徐天英 | Chinese medicine prescription for treating epilepsy |
Non-Patent Citations (4)
| Title |
|---|
| 中西医结合治疗小儿癫痫的临床观察;田一飞;《中国医药学报》;20020515;第17卷(第05期);全文 * |
| 中西医结合治疗难治性癫痫52例;何保军等;《陕西中医》;20050225;第26卷(第02期);全文 * |
| 何保军等.中西医结合治疗难治性癫痫52例.《陕西中医》.2005,第26卷(第02期),全文. |
| 田一飞.中西医结合治疗小儿癫痫的临床观察.《中国医药学报》.2002,第17卷(第05期),全文. |
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