CN104042931A - Medicament for treating ulcerative colitis (UC) - Google Patents
Medicament for treating ulcerative colitis (UC) Download PDFInfo
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- CN104042931A CN104042931A CN201410330132.0A CN201410330132A CN104042931A CN 104042931 A CN104042931 A CN 104042931A CN 201410330132 A CN201410330132 A CN 201410330132A CN 104042931 A CN104042931 A CN 104042931A
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Abstract
The invention discloses a medicament for treating ulcerative colitis (UC). The medicament is prepared from the following traditional Chinese medicines in parts by weight: 12-24 parts of cudweed herb, 12-24 parts of lance asiabell root, 12-24 parts of marsdenia tenacissima, 5-15 parts of soapberry, 5-15 parts of dioscorea nipponica makino, 5-15 parts of ramie root, 5-15 parts of spina date seeds, 4-10 parts of Chinese arborvitae kernel, 4-10 parts of silktree albizia bark, 4-10 parts of dendrobe, 4-10 parts of glossy privet fruit, 4-10 parts of lilium brownii, 3-7 parts of herba gentianopsis paludosae, 3-7 parts of radix asparagi, 3-7 parts of radix codonopsis, 3-7 parts of liquorice, 3-7 parts of flos sophorae and 3-7 parts of impatiens balsamina. The medicament has the beneficial effects that the medicament has the advantages of good curative effects on UC, short course of treatment, small side effects, convenience in use and the like.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically refer to a kind of medicament for the treatment of ulcerative colitis.
Background technology
Ulcerative colitis claims again nonspecific ulcerative colitis, is a kind of rectum and colonic diseases.Primary disease is mainly in person between twenty and fifty, and in recent years, along with the change of people's dietary structure, living habit and rhythm of life, sickness rate has obvious ascendant trend.Clinical manifestation is the repeatedly diarrhoea of unknown cause every day, with having blood in stool or Mucous Stool and stomachache, is outbreak repeatedly more.The primary disease cause of disease is still not clear at present, and onset is slowly most, minority Acute onset.
Doctor trained in Western medicine mainly adopts the method for Drug therapy and operative treatment to the treatment of this disease, western medicine is taking oral as main, and the dose for oral use adopting due to the pathological changes of colon section far away is large, and curative effect is unsatisfactory, and easily causes more side reaction.Operative treatment wound is large, the more difficult acceptance of patient.
Herbal retention enema method in clinical use for many years, is a reasonable route of administration, is mainly the absorption by intestinal wall, can utilize the semi-transparent permeability of the membrane of intestinal wall to be rapidly absorbed, and causes the therapeutical effect of whole body.
At present, treat this sick coloclysis Chinese drugs agentia and have that therapeutic effect is poor, slow problem takes effect.
Summary of the invention
In order to make up the deficiencies in the prior art, the invention provides the medicament of a kind of good effect, short treating period, side effect treatment ulcerative colitis little, easy to use.Specifically be achieved by the following technical solution:
Treat a medicament for ulcerative colitis, made by the Chinese crude drug of following weight portion: 12 ~ 24 parts of Herba Gnaphalii Affinis, 12 ~ 24 parts of Radix Codonopsis Lanceolatae, 12 ~ 24 parts of Caulis Marsdeniae Tenacissimaes, 5 ~ 15 parts of Fructus Sapindi Mukouossis, 5 ~ 15 parts of Rhizoma Dioscoreae Nipponicae, 5 ~ 15 parts of Radix Boehmeriaes, 5 ~ 15 parts of Semen Ziziphi Spinosaes, 4 ~ 10 parts of Semen Platycladi, 4 ~ 10 parts of Cortex Albiziaes, 4 ~ 10 parts of Herba Dendrobiis, 4 ~ 10 parts of Fructus Ligustri Lucidi, 4 ~ 10 parts of Bulbus Liliies, 3 ~ 7 parts of Shi Sheng pivot flower buds, 3 ~ 7 parts of Radix Asparagi, 3 ~ 7 parts of Radix Codonopsis, 3 ~ 7 parts, Radix Glycyrrhizae, 3 ~ 7 parts, Flos Sophorae, 3 ~ 7 parts of Flos Impatientiss.
Preferably, treat a medicament for ulcerative colitis, made by the Chinese crude drug of following weight portion: 18 parts of Herba Gnaphalii Affinis, 18 parts of Radix Codonopsis Lanceolatae, 18 parts of Caulis Marsdeniae Tenacissimaes, 10 parts of Fructus Sapindi Mukouossis, 10 parts of Rhizoma Dioscoreae Nipponicae, 10 parts of Radix Boehmeriaes, 10 parts of Semen Ziziphi Spinosaes, 7 parts of Semen Platycladi, 7 parts of Cortex Albiziaes, 7 parts of Herba Dendrobiis, 7 parts of Fructus Ligustri Lucidi, 7 parts of Bulbus Liliies, 5 parts of Shi Sheng pivot flower buds, 5 parts of Radix Asparagi, 5 parts of Radix Codonopsis, 5 parts, Radix Glycyrrhizae, 5 parts, Flos Sophorae, 5 parts of Flos Impatientiss.
The preparation method of the medicament of above-mentioned treatment ulcerative colitis is: the Chinese crude drug that takes described weight portion is put into drug-decocting appliance, adds clean water 1000 weight portions that meet drinking water standard; Enter to decoct front immersion half an hour, make it fully moistening, fully fried in order to medicine juice; After boiling with high heat, use slow fire boiling half an hour instead, cooled and filtered is removed medicinal residues again, taking liquid and get final product.
The Therapeutic Method of the medicament for the treatment of ulcerative colitis of the present invention: before sleeping every night, after emptying stool, urine, get right arm reclining, make buttocks shift near edge of bed, by intravenous transfusion methods, connect transfusion device, Exhaust Gas, transfusion device cuts off syringe needle, and end is coated a small amount of lubricating oil, insert rectum 10cm left and right from anus slowly, medicinal liquid is slowly splashed into.Fluid temperature is advisable with 37 DEG C of left and right, and pressure is low, and liquid level must not exceed 30cm apart from anus, after having filled with, lies up as far as possible.Coloclysis 1 time before sleeping every night, each about 50ml, 1 month is 1 course for the treatment of, can fully recover general 2 courses for the treatment of.
The medicament for the treatment of ulcerative colitis of the present invention, its beneficial effect is: have the advantages such as good effect, short treating period, side effect be little, easy to use for ulcerative colitis.
detailed description of the invention:
Below in conjunction with embodiment and case, the present invention is further illustrated.
Embodiment 1:
Take Herba Gnaphalii Affinis 12g, Radix Codonopsis Lanceolatae 24g, Caulis Marsdeniae Tenacissimae 12g, Fructus Sapindi Mukouossi 15g, Rhizoma Dioscoreae Nipponicae 5g, Radix Boehmeriae 15g, Semen Ziziphi Spinosae 5g, Semen Platycladi 10g, Cortex Albiziae 4g, Herba Dendrobii 10g, Fructus Ligustri Lucidi 4g, Bulbus Lilii 10g, Shi Sheng pivot flower bud 3g, Radix Asparagi 7g, Radix Codonopsis 3g, Radix Glycyrrhizae 7g, Flos Sophorae 3g, Flos Impatientis 7g puts into drug-decocting appliance, adds the clean water 1000g that meets drinking water standard; Enter to decoct front immersion half an hour, make it fully moistening, fully fried in order to medicine juice; After boiling with high heat, use slow fire boiling half an hour instead, cooled and filtered is removed medicinal residues again, and taking liquid obtains the medicament for the treatment of ulcerative colitis.
Embodiment 2:
Take Herba Gnaphalii Affinis 24g, Radix Codonopsis Lanceolatae 12g, Caulis Marsdeniae Tenacissimae 24g, Fructus Sapindi Mukouossi 5g, Rhizoma Dioscoreae Nipponicae 15g, Radix Boehmeriae 5g, Semen Ziziphi Spinosae 15g, Semen Platycladi 4g, Cortex Albiziae 10g, Herba Dendrobii 4g, Fructus Ligustri Lucidi 10g, Bulbus Lilii 4g, Shi Sheng pivot flower bud 7g, Radix Asparagi 3g, Radix Codonopsis 7g, Radix Glycyrrhizae 3g, Flos Sophorae 7g, Flos Impatientis 3g puts into drug-decocting appliance, adds the clean water 1000g that meets drinking water standard; Enter to decoct front immersion half an hour, make it fully moistening, fully fried in order to medicine juice; After boiling with high heat, use slow fire boiling half an hour instead, cooled and filtered is removed medicinal residues again, and taking liquid obtains the medicament for the treatment of ulcerative colitis.
Embodiment 3:
Take Herba Gnaphalii Affinis 18g, Radix Codonopsis Lanceolatae 18g, Caulis Marsdeniae Tenacissimae 18g, Fructus Sapindi Mukouossi 10g, Rhizoma Dioscoreae Nipponicae 10g, Radix Boehmeriae 10g, Semen Ziziphi Spinosae 10g, Semen Platycladi 7g, Cortex Albiziae 7g, Herba Dendrobii 7g, Fructus Ligustri Lucidi 7g, Bulbus Lilii 7g, Shi Sheng pivot flower bud 5g, Radix Asparagi 5g, Radix Codonopsis 5g, Radix Glycyrrhizae 5g, Flos Sophorae 5g, Flos Impatientis 5g puts into drug-decocting appliance, adds the clean water 1000g that meets drinking water standard; Enter to decoct front immersion half an hour, make it fully moistening, fully fried in order to medicine juice; After boiling with high heat, use slow fire boiling half an hour instead, cooled and filtered is removed medicinal residues again, and taking liquid obtains the medicament for the treatment of ulcerative colitis.
Clinical testing data of the present invention:
During in November, 2011 ~ 2013 year October, choose Xiuzhou City, Anhui Province patients of ulcerative colitis 153 examples, wherein male's 77 examples, women's 76 examples, 17 ~ 58 years old age, 39 years old mean age.Diagnostic criteria: the mucus hemafecia that 1, has persistence or repeatedly show effect, stomachache, with General Symptoms in various degree.2, the multiple fester of the visible mucosa of colonoscope companion congestion and edema, pathological changes mostly from rectum, and is diffusivity and distributes; The coarse fine particulate that is of mucosa, mucosa blood vessel is fuzzy, crisp, easily hemorrhage or with purulent secretion; Visible false polyp, haustra of colon is rust or disappearance often.3, get rid of the diseases such as the infectious colitis such as bacillary dysentery, ameba, schistosomicide, tuberculosis of intestine and Crohn disease, ischemic colitis, radiation colitis.
By random this 153 routine patient, be equally divided into three treatment groups, every group of 51 examples.Wherein, treatment group 1 adopts the pharmaceutical treatment of the embodiment of the present invention 1; Treatment group 2 adopts the pharmaceutical treatment of the embodiment of the present invention 2; Treatment group 3 adopts the pharmaceutical treatment of the embodiment of the present invention 3.
Therapeutic Method: before sleeping every night, after emptying stool, urine, get right arm reclining, make buttocks shift near edge of bed, press intravenous transfusion methods, connect transfusion device, Exhaust Gas, transfusion device cuts off syringe needle, end is coated a small amount of lubricating oil, inserts rectum 10cm left and right slowly from anus, and medicinal liquid is slowly splashed into.Fluid temperature is advisable with 37 DEG C of left and right, and pressure is low, and liquid level must not exceed 30cm apart from anus, after having filled with, lies up as far as possible.Coloclysis 1 time before sleeping every night, each about 50ml, treats 2 months continuously.Greasy, the pungent product of all avoiding eating anything raw or cold during treating, taboo is drunk.
Efficacy assessment standard:
Cure: clinical symptom disappearance, colonoscope check mucosa is normal, and drug withdrawal is observed 6 months without recurrence;
Effective: clinical symptoms substantially disappears or alleviates, only slight pathological changes of intestinal mirror check mucosa;
Invalid: clinical symptoms and mucosa pathological changes are without improvement.
Therapeutic outcome is in table 1:
Table 1 therapeutic outcome
Conclusion:
In clinical trial process, patient finds no any untoward reaction.Before and after treatment, routine blood test of each measurement, liver, renal function, every all normal before and after the treatment of result treatment group, and therefore, medicament of the present invention uses safety.Total effective rate to ulcerative colitis reaches 100%, and wherein the medicament of embodiment 3 is best to the curative effect of ulcerative colitis, cure rate reaches 98.0%, is the active drug for the treatment of ulcerative colitis, has well clinical and dissemination.
The above, be only preferred embodiment of the present invention, is not intended to limit protection scope of the present invention.One skilled in the art will appreciate that protection scope of the present invention is as the criterion with appending claims.
Claims (2)
1. treat the medicament of ulcerative colitis for one kind, it is characterized in that, made by the Chinese crude drug of following weight portion: 12 ~ 24 parts of Herba Gnaphalii Affinis, 12 ~ 24 parts of Radix Codonopsis Lanceolatae, 12 ~ 24 parts of Caulis Marsdeniae Tenacissimaes, 5 ~ 15 parts of Fructus Sapindi Mukouossis, 5 ~ 15 parts of Rhizoma Dioscoreae Nipponicae, 5 ~ 15 parts of Radix Boehmeriaes, 5 ~ 15 parts of Semen Ziziphi Spinosaes, 4 ~ 10 parts of Semen Platycladi, 4 ~ 10 parts of Cortex Albiziaes, 4 ~ 10 parts of Herba Dendrobiis, 4 ~ 10 parts of Fructus Ligustri Lucidi, 4 ~ 10 parts of Bulbus Liliies, 3 ~ 7 parts of Shi Sheng pivot flower buds, 3 ~ 7 parts of Radix Asparagi, 3 ~ 7 parts of Radix Codonopsis, 3 ~ 7 parts, Radix Glycyrrhizae, 3 ~ 7 parts, Flos Sophorae, 3 ~ 7 parts of Flos Impatientiss; Preparation method is: the Chinese crude drug that takes described weight portion is put into drug-decocting appliance, adds clean water 1000 weight portions that meet drinking water standard; Enter to decoct front immersion half an hour, make it fully moistening, fully fried in order to medicine juice; After boiling with high heat, use slow fire boiling half an hour instead, cooled and filtered is removed medicinal residues again, taking liquid and get final product.
2. a kind of medicament for the treatment of ulcerative colitis according to claim 1, it is characterized in that, made by the Chinese crude drug of following weight portion: 18 parts of Herba Gnaphalii Affinis, 18 parts of Radix Codonopsis Lanceolatae, 18 parts of Caulis Marsdeniae Tenacissimaes, 10 parts of Fructus Sapindi Mukouossis, 10 parts of Rhizoma Dioscoreae Nipponicae, 10 parts of Radix Boehmeriaes, 10 parts of Semen Ziziphi Spinosaes, 7 parts of Semen Platycladi, 7 parts of Cortex Albiziaes, 7 parts of Herba Dendrobiis, 7 parts of Fructus Ligustri Lucidi, 7 parts of Bulbus Liliies, 5 parts of Shi Sheng pivot flower buds, 5 parts of Radix Asparagi, 5 parts of Radix Codonopsis, 5 parts, Radix Glycyrrhizae, 5 parts, Flos Sophorae, 5 parts of Flos Impatientiss.
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| CN201410330132.0A CN104042931A (en) | 2014-07-13 | 2014-07-13 | Medicament for treating ulcerative colitis (UC) |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105641438A (en) * | 2016-01-19 | 2016-06-08 | 王向丽 | Traditional Chinese medicine for treating intestinal collateral blood stasis type ulcerative colitis and preparation method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102085335A (en) * | 2011-01-20 | 2011-06-08 | 谭振花 | Traditional Chinese medicine enema for treating ulcerative colitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102085335A (en) * | 2011-01-20 | 2011-06-08 | 谭振花 | Traditional Chinese medicine enema for treating ulcerative colitis |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105641438A (en) * | 2016-01-19 | 2016-06-08 | 王向丽 | Traditional Chinese medicine for treating intestinal collateral blood stasis type ulcerative colitis and preparation method |
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Application publication date: 20140917 |