CN104225260B - A kind of bowel lavage traditional Chinese medicine powder for treating ulcerative colitis - Google Patents

A kind of bowel lavage traditional Chinese medicine powder for treating ulcerative colitis Download PDF

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CN104225260B
CN104225260B CN201410540618.7A CN201410540618A CN104225260B CN 104225260 B CN104225260 B CN 104225260B CN 201410540618 A CN201410540618 A CN 201410540618A CN 104225260 B CN104225260 B CN 104225260B
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charcoal
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CN104225260A (en
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杨华岳
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Abstract

Bowel lavage traditional Chinese medicine powder the present invention relates to treat ulcerative colitis, can effectively solve the problems, such as to treat the medication of ulcerative colitis, and method is, by weight meter:0.5 10 parts of indigo naturalis, 0.8 15 parts of dragon's blood, 0.8 12 parts of catechu, 0.8 15 parts of the bletilla striata, 0.8 12 parts of pearl processed, 15 parts of 0.5 10 parts of stir-baked SQUAMA MANITIS and Uroctea compatilis Koch. charcoal are made, by indigo naturalis, dragon's blood, catechu, the bletilla striata, pearl processed, stir-baked SQUAMA MANITIS and Uroctea compatilis Koch. charcoal are mixed, it was developed into the fine powder of 200 mesh sieves, sterilizing, packaging and storing, , scientific formula of the present invention is reasonable, abundant raw materials, easily production, low cost, with clearing away heat to stop bleeding, promoting blood circulation sore, the effect of convergence myogenic, effective for treatment ulcerative colitis, curative effect stabilization, drug safety, effect is good.

Description

A kind of bowel lavage traditional Chinese medicine powder for treating ulcerative colitis
Technical field
The present invention relates to medicine, particularly a kind of bowel lavage traditional Chinese medicine powder for treating ulcerative colitis.
Background technology
Ulcerative colitis, also known as chronic nonspecific ulcerative colitis, is a kind of not clear rectum of reason and colitis Property disease.The course of disease is very long, and weight differs, recurrent exerbation, is many with person between twenty and fifty.Reason is failed to understand, but its morbidity may be with infection, something lost The factors such as biography, immune, spirit are relevant, and onset is most slow.
The initial performance of ulcerative colitis can have many forms.Bloody diarrhea is most common early symptom.Other diseases Shape have successively stomachache, have blood in stool, weight loss, it is tenesmus, vomiting etc..It is mainly shown as arthritis once in a while, iridocyclitis, Hepatosis and cutaneous lesions.It is a uncommon sign that heating is then relative, and this disease shows as slowly in most patient It is property, low pernicious, in a few patients(Account for 15%)In be in acute, the calamitous process broken out.These patients show as frequent courage and uprightness Excrement, can up to 30 times/day, and hyperpyrexia, stomachache.
Sign is directly related with stadium and clinical manifestation, and patient often has weight loss and pale complexion, in disease activity Colon site often has tenderness during phase abdomen examination.May have that acute abdomen sign occurs together heat and gurgling sound is reduced, in acute attack or Fulminant type case is particularly evident.Can there are abdominal distension, heating and acute abdomen sign during TMC.Due to frequently suffering from diarrhoea, crissum Skin can have scratch, strip off.Crissum inflammation such as anal fissure or anal fistula can also occur, although the latter is more common in Crohn diseases.Directly Intestines refer to inspection sense pain.The inspection of skin, mucous membrane, tongue, joint and eye is particularly important.At present, though treatment ulcerative colitis has Multi-medicament, such as salicylazosulfapyridine, Salicylic Acid Formulations, immunodepressant, but for various reasons, it is used with curative effect simultaneously Unsatisfactory, can Chinese medicine be a big treasure-house, have the affluent resources for treating various diseases, then develop a kind of Chinese medicine, effective It is that people are concerned about the technical problem to be solved in treatment ulcerative colitis.
The content of the invention
For above-mentioned situation, to overcome the defect of prior art, the purpose of the present invention to be just to provide one kind and treat exedens The bowel lavage traditional Chinese medicine powder of colitis, can effectively solve the problems, such as to treat the medication of ulcerative colitis.
The technical scheme that the present invention is solved is that the present invention should control acute attack in treatment, maintains to alleviate, and is reduced multiple Hair, treat complication, according to traditional Chinese medicine and pharmacy principle, should be with clearing away heat to stop bleeding, promoting blood circulation sore, the basic original that convergence myogenic is treatment Then, accordingly, the present invention is using by following weight meter:Indigo naturalis 0.5-10 parts, dragon's blood 0.8-15 parts, catechu 0.8-12 parts, the bletilla striata 0.8-15 parts, pearl 0.8-12 parts processed, stir-baked SQUAMA MANITIS 0.5-10 parts and Uroctea compatilis Koch. charcoal 1-5 parts is made, and wherein Uroctea compatilis Koch. charcoal is, wall money is put In heat watt on, carry out ironing withered into Uroctea compatilis Koch. charcoal, then be developed into powder;Pearl processed is to clean pearl, loads gauze wrapped, With bean curd with boiling 2 hours, take out and clean, fine grinding into impalpable powder is smashed to pieces, per 1kg pearls bean curd 2kg;Stir-baked SQUAMA MANITIS is to wear Naze peels off cot, struts and dries into crust, puts to scald in boiling water and boils, and sloughs first piece, dries, and is fried to foaming and intumescing with sand, in gold Yellow, weeds out sand, obtains stir-baked SQUAMA MANITIS;Indigo naturalis, dragon's blood, catechu, the bletilla striata, pearl processed, stir-baked SQUAMA MANITIS and Uroctea compatilis Koch. charcoal are mixed, The fine powder of 200 mesh sieves was developed into, was sterilized, packaging and storing,.
Scientific formula of the present invention rationally, with clearing away heat to stop bleeding, promoting blood circulation sore, receive by abundant raw materials, easily production, low cost The effect of holding back myogenic, effective for treatment ulcerative colitis, curative effect stabilization, drug safety, effect is good, is the exedens knot for the treatment of A big innovation on enteritis Chinese medicine.
Specific embodiment
Specific embodiment of the invention is elaborated with reference to embodiments.
Embodiment 1
In the specific implementation, the Chinese medicine can also be by following weight meter for the present invention:Indigo naturalis 4-7 parts, dragon's blood 5-12 parts, catechu 3-9 parts, bletilla striata 5-12 parts, pearl 3-9 parts processed, stir-baked SQUAMA MANITIS 4-7 parts and Uroctea compatilis Koch. charcoal 2.5-4.5 parts is made, by indigo naturalis, dragon's blood, youngster Tea, the bletilla striata, pearl processed, stir-baked SQUAMA MANITIS and Uroctea compatilis Koch. charcoal are mixed, and are developed into the fine powder of 200 mesh sieves, sterilizing, packaging and storing, ;Or by indigo naturalis 4-7g, dragon's blood 5-12g, catechu 3-9g, bletilla striata 5-12g, pearl 3-9g processed, stir-baked SQUAMA MANITIS 4-7g and Uroctea compatilis Koch. charcoal 2.5-4.5g is made, and indigo naturalis, dragon's blood, catechu, the bletilla striata, pearl processed, stir-baked SQUAMA MANITIS and Uroctea compatilis Koch. charcoal are mixed, and is developed into The fine powder of 200 mesh sieves, sterilizing, packaging and storing,.
Embodiment 2
In the specific implementation, the Chinese medicine is by following weight meter to the present invention:It is 1 part of indigo naturalis, 14 parts of dragon's blood, 1 part of catechu, white 2 parts of 14 parts of splendid achnatherum, 1 part of pearl processed, 9 parts of stir-baked SQUAMA MANITIS and Uroctea compatilis Koch. charcoal are made, by indigo naturalis, dragon's blood, catechu, the bletilla striata, pearl processed, stir-baked SQUAMA MANITIS Mixed with Uroctea compatilis Koch. charcoal, be developed into the fine powder of 200 mesh sieves, sterilized, packaging and storing,;Or by indigo naturalis 1g, dragon's blood 14g, catechu 1g, bletilla striata 14g, pearl 1g processed, stir-baked SQUAMA MANITIS 9g and Uroctea compatilis Koch. charcoal 2g are made, and indigo naturalis, dragon's blood, catechu, the bletilla striata, system is precious Pearl, stir-baked SQUAMA MANITIS and Uroctea compatilis Koch. charcoal are mixed, and are developed into the fine powder of 200 mesh sieves, sterilizing, packaging and storing,.
Embodiment 3
In the specific implementation, the Chinese medicine can also be by following weight meter for the present invention:9 parts of indigo naturalis, 1 part of dragon's blood, 11 parts of catechu, 4 parts of 1 part of the bletilla striata, 11 parts of pearl processed, 1 part of stir-baked SQUAMA MANITIS and Uroctea compatilis Koch. charcoal are made, by indigo naturalis, dragon's blood, catechu, the bletilla striata, pearl processed, big gun mountain First and Uroctea compatilis Koch. charcoal are mixed, and are developed into the fine powder of 200 mesh sieves, sterilizing, packaging and storing,;Or by indigo naturalis 9g, dragon's blood 1g, catechu 11g, bletilla striata 1g, pearl 11g processed, stir-baked SQUAMA MANITIS 1g and Uroctea compatilis Koch. charcoal 4g are made, and indigo naturalis, dragon's blood, catechu, the bletilla striata, system is precious Pearl, stir-baked SQUAMA MANITIS and Uroctea compatilis Koch. charcoal are mixed, and are developed into the fine powder of 200 mesh sieves, sterilizing, packaging and storing,.
Embodiment 4
In the specific implementation, the Chinese medicine can also be by following weight meter for the present invention:5 parts of indigo naturalis, 7.5 parts of dragon's blood, catechu 6 3 parts of part, 7.5 parts of the bletilla striata, 6 parts of pearl processed, 5 parts of stir-baked SQUAMA MANITIS and Uroctea compatilis Koch. charcoal are made, by indigo naturalis, dragon's blood, catechu, the bletilla striata, pearl processed, Stir-baked SQUAMA MANITIS and Uroctea compatilis Koch. charcoal are mixed, and are developed into the fine powder of 200 mesh sieves, sterilizing, packaging and storing,;Or by indigo naturalis 5g, Dragon's blood 7.5g, catechu 6g, bletilla striata 7.5g, pearl 6g processed, stir-baked SQUAMA MANITIS 5g and Uroctea compatilis Koch. charcoal 3g are made, by indigo naturalis, dragon's blood, catechu, white Splendid achnatherum, pearl processed, stir-baked SQUAMA MANITIS and Uroctea compatilis Koch. charcoal are mixed, and are developed into the fine powder of 200 mesh sieves, sterilizing, packaging and storing,.
Mutually supported between each component of the present invention, with clearing away heat to stop bleeding, promoting blood circulation sore, convergence myogenic the effect of, can be effective In treatment ulcerative colitis, and through clinical test, very satisfied Advantageous Effects are achieved, relevant clinical data is such as Under:
First, the standard of case is selected
The initial performance of ulcerative colitis can have many forms.Bloody diarrhea is most common early symptom.Other diseases Shape have successively stomachache, have blood in stool, weight loss, it is tenesmus, vomiting etc..It is mainly shown as arthritis once in a while, iridocyclitis, Hepatosis and cutaneous lesions.It is a uncommon sign that heating is then relative, and this disease shows as slowly in most patient It is property, low pernicious, in a few patients(Account for 15%)In be in acute, the calamitous process broken out.These patients show as frequent courage and uprightness Excrement, can up to 30 times/day, and hyperpyrexia, stomachache.It is all with above-mentioned symptom person, can alternatively case standard.
2nd, diagnostic criteria
It is all to exclude other specific colonic diseases with above-mentioned symptom, and enteral mirror or x-ray barium enema are checked, are found There is ulcer surface focus, you can be diagnosed as ulcerative colitis.
3rd, therapeutic scheme
Chinese medicine treated powder of the present invention is used to making a definite diagnosis the patient for suffering from ulcerative colitis, when using, traditional Chinese medicine powder 5-10g is used Warm saline is made suspension, the bowel lavage before sleeping every night, retains more than 5 hours, 10 days as one therapeutic course, is united after 5 courses for the treatment of Meter curative effect.
4th, efficacy assessment standard
It is effective:Clinical symptom disappearance, colonoscopy mucous membrane is substantially normal.
Effectively:Clinical symptoms are disappeared substantially, and Sigmoidoscope check mucous membrane mild inflammation or pseudopolyp are formed.
It is invalid:Clinical symptoms, scope and pathologic finding are without improvement after treatment.
5th, statistical procedures
Clinic presses above-mentioned therapeutic scheme and efficacy assessment standard through to 112 patients with ulcerative colitis, uses SPSSlO.O statistical softwares are processed, P≤0.05, and with statistical significance, curative effect statistics is as follows:
Effective 65 people, accounts for 58%, and effective 45 people accounts for 40.2%, and invalid 2 people accounts for 1.8%, total effective rate 98.2%, in the medication phase Between find no any toxic and side effect, show drug safety, curative effect is reliable and stable.
6th, model case
Wang, female, 46 years old, ulcerative colitis medical history 4 years symptoms include:Mucopurulent bloody stool day row 4-6 times with tenesmus, under Belly secret anguish.Once in being in hospital 4 times in half a year, symptom delay is repeatedly refractory.By with after one course for the treatment of of Chinese medicine treated powder of the present invention Symptom has clear improvement or partial symptoms disappear, and is continuously wholly absent using symptom after five courses for the treatment of, is paid a return visit after 1 year and not recurred.
7th, conclusion
By above-mentioned it is clear that the present invention is the active drug for the treatment of ulcerative colitis, drug safety, with clear The effect of thermal hemostasis, promoting blood circulation sore, convergence myogenic, effective for treatment ulcerative colitis, curative effect is high, and total effective rate is up to More than 98%, it is to treat the innovation on ulcerative colitis medicine, economic and social benefit with very strong clinical value Significantly.

Claims (5)

1. a kind of bowel lavage traditional Chinese medicine powder for treating ulcerative colitis, it is characterised in that by following weight meter:Indigo naturalis 0.5-10 Part, dragon's blood 0.8-15 parts, catechu 0.8-12 parts, bletilla striata 0.8-15 parts, pearl 0.8-12 parts processed, stir-baked SQUAMA MANITIS 0.5-10 parts and wall money Charcoal 1-5 parts is made, and wherein Uroctea compatilis Koch. charcoal is, wall money is placed in heat watt on, carry out ironing withered into Uroctea compatilis Koch. charcoal, then be developed into powder; Pearl processed is to clean pearl, loads gauze wrapped, with bean curd with boiling 2 hours, takes out and cleans, and smashs fine grinding into impalpable powder to pieces, Per 1kg pearls bean curd 2kg;Stir-baked SQUAMA MANITIS is that pangolin is peelled off into cot, struts and dries into crust, puts to scald in boiling water and boils, and is sloughed First piece, dries, and is fried to foaming and intumescing with sand, in golden yellow, weeds out sand, obtains stir-baked SQUAMA MANITIS;By indigo naturalis, dragon's blood, catechu, the bletilla striata, Pearl processed, stir-baked SQUAMA MANITIS and Uroctea compatilis Koch. charcoal are mixed, and are developed into the fine powder of 200 mesh sieves, sterilizing,.
2. it is according to claim 1 treatment ulcerative colitis bowel lavage traditional Chinese medicine powder, it is characterised in that by following weight meter 's:Indigo naturalis 4-7 parts, dragon's blood 5-12 parts, catechu 3-9 parts, bletilla striata 5-12 parts, pearl 3-9 parts processed, stir-baked SQUAMA MANITIS 4-7 parts and Uroctea compatilis Koch. charcoal 2.5-4.5 parts is made, and indigo naturalis, dragon's blood, catechu, the bletilla striata, pearl processed, stir-baked SQUAMA MANITIS and Uroctea compatilis Koch. charcoal are mixed, and is developed into The fine powder of 200 mesh sieves, sterilizing,.
3. it is according to claim 1 treatment ulcerative colitis bowel lavage traditional Chinese medicine powder, it is characterised in that by following weight meter 's:2 parts of 1 part of indigo naturalis, 14 parts of dragon's blood, 1 part of catechu, 14 parts of the bletilla striata, 1 part of pearl processed, 9 parts of stir-baked SQUAMA MANITIS and Uroctea compatilis Koch. charcoal are made, by green grass or young crops Black pigment used by women in ancient times to paint their eyebrows, dragon's blood, catechu, the bletilla striata, pearl processed, stir-baked SQUAMA MANITIS and Uroctea compatilis Koch. charcoal are mixed, and are developed into the fine powder of 200 mesh sieves, sterilizing, .
4. it is according to claim 1 treatment ulcerative colitis bowel lavage traditional Chinese medicine powder, it is characterised in that by following weight meter 's:4 parts of 9 parts of indigo naturalis, 1 part of dragon's blood, 11 parts of catechu, 1 part of the bletilla striata, 11 parts of pearl processed, 1 part of stir-baked SQUAMA MANITIS and Uroctea compatilis Koch. charcoal are made, by green grass or young crops Black pigment used by women in ancient times to paint their eyebrows, dragon's blood, catechu, the bletilla striata, pearl processed, stir-baked SQUAMA MANITIS and Uroctea compatilis Koch. charcoal are mixed, and are developed into the fine powder of 200 mesh sieves, sterilizing, .
5. it is according to claim 1 treatment ulcerative colitis bowel lavage traditional Chinese medicine powder, it is characterised in that by following weight meter 's:3 parts of 5 parts of indigo naturalis, 7.5 parts of dragon's blood, 6 parts of catechu, 7.5 parts of the bletilla striata, 6 parts of pearl processed, 5 parts of stir-baked SQUAMA MANITIS and Uroctea compatilis Koch. charcoal are made, will Indigo naturalis, dragon's blood, catechu, the bletilla striata, pearl processed, stir-baked SQUAMA MANITIS and Uroctea compatilis Koch. charcoal are mixed, and are developed into the fine powder of 200 mesh sieves, are gone out Bacterium,.
CN201410540618.7A 2014-10-14 2014-10-14 A kind of bowel lavage traditional Chinese medicine powder for treating ulcerative colitis Expired - Fee Related CN104225260B (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1376489A (en) * 2002-03-08 2002-10-30 天津天士力新资源药业有限公司 Chinese medicine for treating ulcerative colitis and its preparing process
CN1765377A (en) * 2004-10-25 2006-05-03 江西本草天工科技有限责任公司 Orally administered formulation of eight ingredients-containing 'Xi Lei San' and its colon target oral formulation and preparation method
CN101708203A (en) * 2009-11-30 2010-05-19 周景梅 Medicament for treating ulcerative colitis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1376489A (en) * 2002-03-08 2002-10-30 天津天士力新资源药业有限公司 Chinese medicine for treating ulcerative colitis and its preparing process
CN1765377A (en) * 2004-10-25 2006-05-03 江西本草天工科技有限责任公司 Orally administered formulation of eight ingredients-containing 'Xi Lei San' and its colon target oral formulation and preparation method
CN101708203A (en) * 2009-11-30 2010-05-19 周景梅 Medicament for treating ulcerative colitis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
青龙散配合西药治疗慢性溃疡性结肠炎79例;黄裕民;《陕西中医》;20070930;第28卷(第9期);第1184页"治疗方法"和第1185页"讨论" *

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