CN104958631A - Pharmaceutical composition for treating kidney stones and preparation method of pharmaceutical composition - Google Patents
Pharmaceutical composition for treating kidney stones and preparation method of pharmaceutical composition Download PDFInfo
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- CN104958631A CN104958631A CN201510463707.0A CN201510463707A CN104958631A CN 104958631 A CN104958631 A CN 104958631A CN 201510463707 A CN201510463707 A CN 201510463707A CN 104958631 A CN104958631 A CN 104958631A
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Abstract
The invention provides a pharmaceutical composition for treating kidney stones and a preparation method of the pharmaceutical composition. The pharmaceutical composition is mainly prepared by grinding spicate clerodendranthus herb, clerodendrum indicum, semen coicis root, alfalfa roots, aspidopterys glabriuscula, hairy grape stems, garden burnet and mole cricket, and decocting with water by employing a conventional method. The pharmaceutical composition is fast and effective on treatment of the kidney stones, and is simple in formula, low in cost, easy to produce and suitable for the requirements of most of patients with kidney stones.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly relate to a kind of pharmaceutical composition being used for the treatment of renal calculus and preparation method thereof.
Background technology
Renal calculus, refers to the calculus betiding renal calices, renal pelvis and renal pelvis and ureter connecting portion.Kidney is the lithogenous main portions of urinary system shape, the calculus at other any positions can be primary in kidney, ureteral calculus is almost all from kidney, and renal calculus coup injury kidney easier in other any position calculus, and therefore early diagnosis and therapy is extremely important.Renal calculus is urinary system commonly encountered diseases, frequently-occurring disease, and male's morbidity, more than women, mostly occurs person between twenty and fifty, the sickness rate no significant difference of left and right sides.The renal calculus patient of 40% ~ 75% is had to have lumbago in various degree.Calculus is comparatively large, and degree of excursion is very little, shows as the swollen discomfort of waist acid, or has dull pain or dull pain when body movement increases.Compared with the angor that microlith causes, often suddenly there is the waist and belly sample that lancinates and have an intense pain, in paroxysmal.
indoctor belongs to " stranguria ", " stranguria caused by urinary stone " " hematuria ", " lumbago " etc.In recent years its sickness rate rises gradually, and renal calculus patient there will be pain in various degree, suffers from the patient of renal calculus for a long time, and its body parent is subject to great wound, therefore has positive meaning to the treatment of renal calculus.
Based on this, the invention provides pharmaceutical composition of a kind of novel treatment renal calculus and preparation method thereof, have that curative effect is obvious, cheap, the feature such as have no side effect, especially effect do not discharged in a short time to microlith excellent, compensate for operation, external stone crushing to microlith and muddy stone weak effect or invalid defect, for bulk calculus, under the help of shock wave lithotripsy in vitro, also there is good curative effect.
Summary of the invention
Goal of the invention: technical problem to be solved by this invention is, overcome the deficiency of more existing non-open operations, utilize the theory of Chinese medical science that China is traditional, a kind of Chinese medicine for the treatment of renal calculus is provided, its curative effect is obvious, cheap, have no side effect, cure rate is high, have no drug resistance, effect do not discharged in a short time to microlith excellent, compensate for operation, external stone crushing to microlith and muddy stone weak effect or invalid defect, for bulk calculus, under the help of shock wave lithotripsy in vitro, also there is good curative effect.
Technical scheme: the object of the invention is to be achieved by the following scheme:
A kind of pharmaceutical composition for the treatment of renal calculus, active component contained by it is prepared from by following raw materials in part by weight proportioning: Herba clerodendranthi spicati 40-60, Herba Clerodendri Indici 10-30, Radix Semen Coicis 10-30, Radix Medicaginis 10-30, Caulis Aspidopterydis obcordatae 10-20, Herba Anemones vitifoliae 10-20, Radix Sanguisorbae 8-16, Gryllotalpa 8-16 for can for the purpose of concise description problem, below to a kind of pharmaceutical composition for the treatment of renal calculus of the present invention all referred to as this compositions.
By to boil water after the grinding of this compositions, can take to the decocting liquid of 1500-2000 weight portion after thickening filtration.
A kind of pharmaceutical composition for the treatment of renal calculus, it is characterized in that, the active component contained by it is prepared from by following raw materials in part by weight proportioning: Herba clerodendranthi spicati 50 parts, Herba Clerodendri Indici 20 parts, Radix Semen Coicis 20 parts, Radix Medicaginis 20 parts, Caulis Aspidopterydis obcordatae 15 parts, Herba Anemones vitifoliae 15 parts, Radix Sanguisorbae 12 parts, Gryllotalpa 12 parts.
By to boil water after the grinding of this compositions, can take to the decocting liquid of 1500-2000 weight portion after thickening filtration.
In the present invention, Herba clerodendranthi spicati is the herb of labiate Herba clerodendranthi spicati.The whole year can adopt, and cutting is dried.Sweet, light, the micro-hardship of nature and flavor, cool.Enter liver, bladder, kidney three warp.There is clearing heat and removing internal wetness, calculus diuretic effect.Treatment acute and chronic nephritis, cystitis, lithangiuria, rheumatic arthritis etc.
Radix Medicaginis is the root of leguminous plant alfalfa or medicago hispida.Nature and flavor are bitter, cold, enter Liver and kidney warp.There is clearing away damp-heat, diuresis effect.Treatment jaundice, lithangiuria, nyctalopia etc.
Caulis Aspidopterydis obcordatae derives from the ratan of the Malpighiaceae plant Caulis Aspidopterydis obcordatae of falling lobus cardiacus.The whole year can adopt.Nature and flavor picric acid, cold.Enter lung, kidney, large intestine channel.There is blood on removing heat from blood, heat-clearing and toxic substances removing.Treatment is spitted blood, epistaxis, dysentery, metrorrhagia, hemorrhoidal hamorrhage, anal fistula, carbuncle, eczema, incised wound, burn.
Gryllotalpa is the dry polypide of Gryllotalpidae insecticide Gryllotalpa.Plough between summer, autumn when digging and catch, or lighting trapping in evening.Catch rear boiling water scalds dead, dry or dry.Nature and flavor are salty, cold, slightly poisonous.Enter bladder, large intestine, small intestine meridian.There is diuretic, relieving constipation effect.Treatment edema, stranguria caused by urinary stone, dysuria, scrofula, carbuncle malignant boil etc.
Herba Anemones vitifoliae is Herb and the leaf of vitaceae downy grape.Summer, autumn gather, and clean, dry.Nature and flavor are sweet, flat.There is heat clearing away, hemostasia effect.Treatment rheumatism, measles.Dysentery, sore swollen toxin etc.
Radix Semen Coicis is the root of grass Semen Coicis, and autumn takes.Nature and flavor are bitter, sweet, cold.Enter spleen, bladder, warp.There is heat clearing away, dampness removing, spleen invigorating, parasite killing.Treatment jaundice, edema, gonorrhea, hernia, amenorrhea, leukorrhagia, abdominal pain due to worm stagnation etc.
Herba Clerodendri Indici is Verbenaceae Herba Clerodendri Indici.The whole year can adopt, cutting, dries or using fresh herb.Nature and flavor are bitter, cool.Enter liver, kidney, urinary bladder channel.There is antiinflammatory diuresis, promoting blood circulation and detumescence, wind-damp dispelling etc.Treatment urinary tract infection, cystitis, traumatic injury, rheumatic ostalgia etc.
Radix Sanguisorbae is the root and rhizome of Flos Rosae Multiflorae kind of plant Radix Sanguisorbae.Before germinateing spring or autumn Seedling withered after excavate, remove residual stem and fibrous root, clean and dry.Nature and flavor picric acid, cold.Enter liver, large intestine channel.There is blood on removing heat from blood, heat-clearing and toxic substances removing.Treatment is spitted blood, epistaxis, dysentery, metrorrhagia, hemorrhoidal hamorrhage, anal fistula, carbuncle, eczema, incised wound, burn etc.
The various customary adjuvant that aforementioned pharmaceutical compositions decocting liquid of the present invention is required when preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., being prepared into the conventional oral formulations of any one with the method for Chinese medicinal of routine, such as, can be pill, capsule, tablet, granule or water decoction etc.
Pharmaceutical composition of the present invention is based on the differential diagnosis of diseases of Chinese medicine renal calculus and the dialectical principle that combines, giving consideration to both the incidental and fundamental, deficiency and excess is also controlled, filter out tonifying speen and tonifying kidney, regulating fluid apssage, relieving stranguria by diuresis, heat-clearing and toxic substances removing, inducing diuresis and reducing edema pharmaceutical composition, according to theory of Chinese medical science prescription, be prepared from according to certain weight proportion.
Usage and consumption: dosage of the present invention depends on concrete dosage form, the factor such as age, body weight, health status of patient.As guidance: for oral administration: 1) capsule: every day three times, each serving 3 ~ 6, every content of dispersion 0.3g, warm water takes.2) tablet: every day three times, each serving 3 ~ 6, every sheet content of dispersion 0.3g, warm water takes.3) pill: every day three times, each serving 8g, warm water takes.4) water decoction: every day three times, each serving with 30 ~ 60 milliliters.
Detailed description of the invention
Further describe the present invention by the following examples, it should be understood that these embodiments only for the object of illustration, never limit the scope of the invention.
The preparation of [embodiment 1] capsule
Each raw material is taken: Herba clerodendranthi spicati 50g, Herba Clerodendri Indici 20g, Radix Semen Coicis 20g, Radix Medicaginis 20g, Caulis Aspidopterydis obcordatae 15g, Herba Anemones vitifoliae 15g, Radix Sanguisorbae 12g, Gryllotalpa 12g by following weight.Cross add 2000g soak by water by being ground into fine powder after the mixing of each component of above-mentioned weight, filter, concentrated oven dry incapsulates and get final product after powder crosses 1500 mesh sieves.
The preparation of [embodiment 2] water decoction
Each raw material is taken: Herba clerodendranthi spicati 50g, Herba Clerodendri Indici 20g, Radix Semen Coicis 20g, Radix Medicaginis 20g, Caulis Aspidopterydis obcordatae 15g, Herba Anemones vitifoliae 15g, Radix Sanguisorbae 12g, Gryllotalpa 12g by following weight.Cross add 2000g soak by water by being ground into fine powder after the mixing of each component of above-mentioned weight, filter, concentrate and get final product.
[embodiment
3]the preparation of tablet
Each raw material is taken: Herba clerodendranthi spicati 50g, Herba Clerodendri Indici 20g, Radix Semen Coicis 20g, Radix Medicaginis 20g, Caulis Aspidopterydis obcordatae 15g, Herba Anemones vitifoliae 15g, Radix Sanguisorbae 12g, Gryllotalpa 12g by following weight.Cross add 2000g soak by water by being ground into fine powder after the mixing of each component of above-mentioned weight, filter, concentrated dry cross 1500 mesh sieves to powder after, make granule, and dry tabletted and get final product.
The preparation of [embodiment 4] pill
Each raw material is taken: Herba clerodendranthi spicati 50g, Herba Clerodendri Indici 20g, Radix Semen Coicis 20g, Radix Medicaginis 20g, Caulis Aspidopterydis obcordatae 15g, Herba Anemones vitifoliae 15g, Radix Sanguisorbae 12g, Gryllotalpa 12g by following weight.Cross add 2000g soak by water by being ground into fine powder after the mixing of each component of above-mentioned weight, filter, concentratedly to dry, be ground into after fine powder crosses 80-200 mesh sieve, make pill and get final product.
clinical trial example
The clinical observation on the therapeutic effect test of medicine composite for curing renal calculus patient of the present invention.
1. the physical data of subjects: adopt pharmaceutical composition of the present invention to treat 100 routine patients altogether, wherein man 65 example, female 35 example; The oldest person 74 years old, age reckling 18 years old.
2. Therapeutic Method: usage and consumption: adopt the medicament prepared by the embodiment of the present invention, its usage and consumption as follows: 1) capsule: take three every day, each serving 3-6, every content of dispersion 0.3g, warm water takes.2) tablet: take three every day, each serving 3-6, every sheet content of dispersion 0.3g, warm water takes.3) pill: take three every day, each serving 8g, warm water takes.4) water decoction: every day three times, each serving using 30-60 milliliter.
The course for the treatment of: 15 days be a course for the treatment of, treat 2 courses for the treatment of altogether.
3. efficacy assessment standard: cure: calculus is discharged or disappeared through B super inspection calculus, and symptom and sign all disappear.Effective: part calculus is discharged or reduced through B super inspection calculus, move down, and symptom and sign obviously alleviate.Invalid: calculus has no discharge, through B super inspection calculus situation without change, symptom and sign are not improved.
Test group adopts pharmaceutical composition water decoction of the present invention to treat, and during treatment, administrated method is: daily three times, early, middle and late each once, one time 50 milliliters, period in a medicine fasting raw food raw meat food, serve on 1 month.Matched group gives domestic Sal Nitri capsule, and every day three times, each 4-6 grain, serve on 1 month.
Two groups of cases all observe cardinal symptom and sign in 1 month after medication.
Therapeutic outcome: two groups of 1 week check B that all had a rest after a month course for the treatment of surpass, and observe therapeutic effect.
Table 1 is visible, and treatment group cure rate is 66.66%, total effective rate 95%, matched group cure rate 55%, total effective rate 75%, by relatively showing that treatment group curative effect is better than matched group (P < 0.001).
Model case 1
Chen, man, 49 years old, in November, 2013 went to a doctor.The right waist and belly pain of patient 3 hours, surpass through B, diagnose right renal calculus after urine examination, calculus 0.5cm × 0.5cm size, take analgesic, but pain stops not yet completely.Look into: You Shen district kowtows pain, right ureter epimere tenderness, picture of the tongue is normal, deep and stringy pulse.Chinese medical discrimination is that the mechanism of qi stasis of blood is stagnant, and passages through which vital energy circulates is obstructed, takes the water decoction in the embodiment of the present invention 2, each 50 milliliters, every day 3 times.Patient only takes pain on the 5th and namely stops, and following the service 10 days checks that B is super has no calculus sign afterwards.Follow up a case by regular visits to the half a year state of an illness without repeatedly.
Model case 2
In certain, female, 42 years old, in June, 2013 went to a doctor, the left renal calculus of patient 2 years, once carried out the external ripple rubble 3 times of shaking at Hospital, take traditional Chinese medicine and uralyt invalid for half a year.Disease sees left waist paroxysmal colic, frequent micturition, dripping not smooth, yellowish urine, and constipation, there is petechia on red tongue limit, yellow fur, and wiry and frequent pulse is had a medical check-up: Zuo Shen district kowtows pain (+).Urinary system B is super to be checked: left renal calculus 1.0cm × 0.8cm, left ureter epimere expansion companion hydrops in a small amount.Card belongs to blood-stasis internal-depression, and damp-heat accumulation, takes the Chinese medicine decoction in the embodiment of the present invention 2, checks that B is super has no calculus sign after serveing on 1 month.Follow up a case by regular visits to the half a year state of an illness without repeatedly.
toxicological study
Acute toxicity test shows, rat oral gavage pharmaceutical composition water decoction of the present invention fails to measure LD50.
Long term toxicity test: rat divides into groups, pharmaceutical composition decocting gavage of the present invention, every day three times, continuous 90 days, result, administration group rat and control rats movable, search for food, drink water, body weight and the multinomial observation index such as substantial viscera pathologic finding and pathological tissue detect, result of the test does not all find any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
This pharmaceutical composition is all negative to the zest of blood vessel, allergy and hemolytic test.
In sum, the present invention is a kind of pharmaceutical composition of excellent treatment renal calculus, obviously can strengthen its tonifying speen and tonifying kidney, regulating fluid apssage, relieving stranguria by diuresis, heat-clearing and toxic substances removing, inducing diuresis and reducing edema.Long-term taking safety, therefore, clinic is applied.
All above-mentioned this intellectual properties of primary enforcement, not setting this new product of the other forms of enforcement of restriction and or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (4)
1. a pharmaceutical composition for the treatment of renal calculus is made up of the weight ratio mixing of Herba clerodendranthi spicati 40-60 part, Herba Clerodendri Indici 10-30 part, Radix Semen Coicis 10-30 part, Radix Medicaginis 10-30 part, Caulis Aspidopterydis obcordatae 10-20 part, Herba Anemones vitifoliae 10-20 part, Radix Sanguisorbae 8-16 part, Gryllotalpa 8-16 part.
2. according to any one pharmaceutical composition according to claim 1, it is characterized in that: method of Chinese medicinal routinely can be prepared into the conventional oral formulations of any one.
3. according to the pharmaceutical composition described in claim 2, it is characterized in that: described oral formulations is pill, capsule, tablet, water decoction.
4. the application of the arbitrary pharmaceutical composition described in claim 1-3 in preparation treatment renal calculus medicine.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194075A (en) * | 2015-10-19 | 2015-12-30 | 济南邦文医药科技有限公司 | Traditional Chinese medicine composition for treating residual stones (caused by heat-damp syndrome) after percutaneous nephrolithotomy of lithangiuria |
Citations (3)
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|---|---|---|---|---|
| CN101829188A (en) * | 2010-05-13 | 2010-09-15 | 西双版纳傣族自治州民族医药研究所 | Medicament for treating urinary infection and lithiasis |
| CN101856388A (en) * | 2010-06-01 | 2010-10-13 | 新平彝族傣族自治县民族医药研究学会 | Medicament for treating urinary calculus and benign prostatic hyperplasia |
| CN102441122A (en) * | 2011-12-13 | 2012-05-09 | 戴天高 | Traditional Chinese medicinal formula for treating kidney stone and decoction method |
-
2015
- 2015-08-02 CN CN201510463707.0A patent/CN104958631A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101829188A (en) * | 2010-05-13 | 2010-09-15 | 西双版纳傣族自治州民族医药研究所 | Medicament for treating urinary infection and lithiasis |
| CN101856388A (en) * | 2010-06-01 | 2010-10-13 | 新平彝族傣族自治县民族医药研究学会 | Medicament for treating urinary calculus and benign prostatic hyperplasia |
| CN102441122A (en) * | 2011-12-13 | 2012-05-09 | 戴天高 | Traditional Chinese medicinal formula for treating kidney stone and decoction method |
Non-Patent Citations (1)
| Title |
|---|
| 马汴梁: "《得了肾结石怎么办》", 31 July 2012, 金盾出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194075A (en) * | 2015-10-19 | 2015-12-30 | 济南邦文医药科技有限公司 | Traditional Chinese medicine composition for treating residual stones (caused by heat-damp syndrome) after percutaneous nephrolithotomy of lithangiuria |
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Application publication date: 20151007 |