CN101708203A - Medicament for treating ulcerative colitis - Google Patents
Medicament for treating ulcerative colitis Download PDFInfo
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- CN101708203A CN101708203A CN200910172794A CN200910172794A CN101708203A CN 101708203 A CN101708203 A CN 101708203A CN 200910172794 A CN200910172794 A CN 200910172794A CN 200910172794 A CN200910172794 A CN 200910172794A CN 101708203 A CN101708203 A CN 101708203A
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Abstract
The invention provides a medicament for treating ulcerative colitis and relates to the medicament for treating colitis. The medicament is prepared by selecting the following raw materials by mass: 3 to 5g of synthetic bovine bezoar, 1.5 to 2.5g of borneol, 19 to 27g of pearl, 19 to 27g of ivory flakes, 88 to 100g of natural indigo and 13 to 19g of wall spider, grinding the raw materials are into powder, passing the power through a screen, and mixing the power to form mixed powder A; mixing 40,000 to 80,000 units of gentamicin and 30 to 50 ml of metronidazole solution to form gentamicin-metronidazole solution, and dissolving 1 percent of the mixed powder A into the gentamicin-metronidazole solution. The medicament has the advantages that: the medicament treats the ulcerative colitis and proctitis by a clysis method. The medicament can directly reach affected parts, can improve local blood concentration in intestines, avoids first-pass effect of liver, prevents or reduces damage of medicament to the liver and damage of digestive juice of stomach and intestines, and digestive enzyme to the medicament, and gives full play to availability of the medicament. The medicament also has the advantages of addressing of symptoms and root causes, rapid medicinal effect, safety, reliability and good curative effect. 156 clinical tests show that the effective rate of the medicament reaches 100 percent.
Description
Technical field:
The present invention relates to medicine, further is the medicine of treatment colitis, particularly treats the Chinese medicine or the Chinese medicine and western medicine mixture of ulcerative colitis.
Background technology:
Ulcerative colitis claims chronic non-specific ulcerative colitis again, and the pathological changes multidigit also can spread to descending colon in rectum and sigmoid colon, even whole colon.Clinical whole symptom is diarrhoea, bloody purulent stool, stomachache and tenesmus.Modern medicine thinks that self cellular immunization is unusual, cause mucosa destroyed, or because Nervous and Mental Factors causes the cerebral cortex moving obstacle, autonomic nervous dysfunction and to produce intestinal movement hyperfunction, intestinal vascular smooth muscle spasm is shunk, tissue ischemia, capillary permeability increases, thereby forms inflammation, erosion and the ulcer of intestinal mucosa.
Long, obstinate, the easily recurrence of the colitis course of disease treat quite thornyly, is classified as one of modern difficult treatment by World Health Organization (WHO), is the trend of rising gradually in recent years.At present, the proctitis of western medical treatment ulcerative colitis mainly contains a few class medicines such as sulfonamides, antibiotics, hormones, immunosuppressant, said medicine all proves to have reliable therapeutic effect by the long-term test of pesticide effectiveness and clinical trial, but toxicity is big mostly, side effect is many, symptoms such as nausea and vomiting, headache, general malaise are often arranged as oral sulfa drugs, or cause leukopenia, arthritis, erythra, albuminuria etc.; The oral gastrointestinal irritation that easily causes of antibiotic medicine, the intravenous administration side effect is big; Immunosuppressant is bigger to the influence of hemopoietic function of bone marrow, answers the periodic review bone marrow smear in the medication process.
Therefore, it is good to seek to have therapeutic effect, Chinese medicine that untoward reaction is few or Chinese medicine and western medicine mixture just seem very urgent and needs, and the research of actively developing this respect has important use and is worth and clinical finger meaning.
Summary of the invention:
Purpose of the present invention is exactly the defective that exists in the existing Drug therapy, and a kind for the treatment of both the principal and secondary aspects of a disease, the treatment ulcerative colitis that drug effect is rapid, safe and reliable, therapeutic effect is good, the medicine of proctitis are provided.
The objective of the invention is to realize by following scheme: a kind of medicine for the treatment of ulcerative colitis is characterized in that: a chooses the raw material of following weight: artificial Calculus Bovis's 3～5 grams, Borneolum Syntheticum 1.5～2.5 grams, Margarita 19～27 grams, Dens Elephatis 19～27 grams, Indigo Naturalis 88～100 grams, Uroctea compatilis Koch. 13～19 grams; Levigation sieves, and mixes, and forms mixed dust formulation A; B gentamycin 4～80,000 units, metronidazole (content 0.1g) liquid 30～50ml mix formation celebrating first liquid (promptly getting the meaning of gentamycin and metronidazole mixed liquor), get one of mixed dust formulation A percentage, and dissolving in this liquid is medicinal liquid.
During making: artificial Calculus Bovis, Borneolum Syntheticum, Margarita, Dens Elephatis, Indigo Naturalis, Uroctea compatilis Koch. (charcoal) are ground into fine powder, cross 100 mesh sieves, mixing, sterilization promptly gets mixed dust formulation A; Mixed dust formulation A, gentamycin, metronidazole liquid are placed respectively; During use, (one of percentage) adds celebrating Da Lei element, metronidazole liquid with mixed dust formulation A temporarily in proportion, makes medicinal liquid, in order to retention enema.Also can in proportion mixed dust formulation A, gentamycin, metronidazole liquid directly be mixed into medicinal liquid.
The present invention can further realize by following scheme:
Among the mixed dust formulation A:
Preferred version is: artificial Calculus Bovis's 3.5～4.5 grams, Borneolum Syntheticum 1.8～2.2 grams, Margarita 21～25 grams, Dens Elephatis 21～25 grams, Indigo Naturalis 91～97 grams, Uroctea compatilis Koch. (charcoal) 14～18 grams.
Preferred plan is: artificial Calculus Bovis's 4 grams, Borneolum Syntheticum 2 grams, Margarita 23 grams, Dens Elephatis 23 grams, Indigo Naturalis 94 grams, Uroctea compatilis Koch. (charcoal) 16 grams.
Can also comprise berberine powder (or Rhizoma Coptidis sheet) 7～13 grams among the mixed dust formulation A.
Gentamycin refers to that powder, metronidazole refer to powder (also the powder that processes of tablet, effective component content is identical with content liquid), and adding distil water 30～50ml mixes to form and celebrates first liquid, gets one of mixed dust formulation A percentage, and dissolving in this liquid is medicinal liquid.
Mixed dust formulation A (can comprise the berberine powder, also can not comprise the berberine powder) is mixed and made into a kind of of powder or capsule or suppository with gentamycin powder, Metronidazole Tablet.
The present invention can also further realize by following scheme:
The b operation is replaced by following scheme: get Rhizoma Coptidis 10～15 grams, the Radix Astragali 10～15 grams, Cortex Phellodendri 10～15 grams, add water 100～200ml and fried in shallow oil 25～35 minutes, filtering residue is three yellow liquors (promptly getting the meaning of Rhizoma Coptidis, the Radix Astragali, Cortex Phellodendri mixed liquor), gets this liquid 30～50ml; With one of mixed dust formulation A percentage, be dissolved in this liquid and become medicinal liquid.In order to retention enema; Also can adopt following method to handle: mixed dust formulation A, three yellow liquors are placed respectively; During use, again mixed dust formulation A is added three yellow liquors in proportion, make medicinal liquid.This medicinal liquid also be can be made into decoction or liquid agent.
Keep a operation, cancellation b operation with Rhizoma Coptidis 10～15 grams, the Radix Astragali 10～15 grams, Cortex Phellodendri 10～15 grams, adds water 100～200ml and fried in shallow oil 25～35 minutes, and filtering residue is three yellow liquors; Get one of the percentage of the mixed dust formulation A in a operation again, add three yellow liquors, fried in shallow oil 1～5 minute, the 30～50ml that takes concoction becomes medicinal liquid.In order to retention enema.
Wherein, the preferred version of Rhizoma Coptidis, the Radix Astragali, Cortex Phellodendri is: Rhizoma Coptidis 11～14 grams, the Radix Astragali 11～14 grams, Cortex Phellodendri 11～14 grams.
Using method: above prescription is adult's ampoule.The Chinese medicine and western medicine admixing medical solutions retention enema of using we to make, once a day, 10 times is a course of treatment.3～7 days at interval each, but reuse next course of treatment course of treatment.General 1～2 the course of treatment clinical symptoms just can disappear substantially.Afterwards, re-use 3～5 courses of treatment, consolidate curative effect, to prevent recurrence.
Configuration mechanism of the present invention: artificial Calculus Bovis, Borneolum Syntheticum, clearing heat, releasing toxin, removing swelling; Indigo Naturalis, the sore-throat relieving that purges heat, cooling blood and relieving pain; Margarita, Dens Elephatis help Indigo Naturalis to catch malicious heat clearing away, removing the necrotic tissue and promoting granulation; Uroctea compatilis Koch. (charcoal), heat-clearing and toxic substances removing, cooling blood and relieving pain; Rhizoma Coptidis, heat clearing and damp drying, eliminating fire and detoxication is used for damp and hot feeling of fullness, dysentery, heat in blood is told nosebleed, carbuncle furuncle, eczema eczema; The Radix Astragali, invigorating QI to consolidate the body surface resistance, the diuresis poison holding, evacuation of pus, expelling pus and promoting granulation is enriched blood, gas in the lifting, enhancing body resistance; Cortex Phellodendri, heat clearing and damp drying, pathogenic fire purging removes steams, and skin ulcer is treated in detoxifcation; Celebrating Da Lei element, metronidazole, anti-inflammation.Berberine Tablet, berberine powder antimicrobial drug are used for the intestinal infection due to the dysentery bacterium.All medicine compatibilities of the present invention have effects such as gas in heat-clearing and toxic substances removing, cooling blood for hemostasis, removing the necrotic tissue and promoting granulation, the lifting, anti-inflammation, enhancing body resistance.
The invention has the beneficial effects as follows: the method that adopts coloclysis with this medicine, treatment ulcerative colitis, proctitis, the medicine sick institute that goes directly, can improve the local blood drug level of enteral, and avoided the first pass effect of liver, prevent or reduce medicine at liver destroyed and gastro-intestinal digestion liquid, digestive enzyme to the destruction of medicine, the availability of medicine has obtained giving full play to, heat-clearing and toxic substances removing, cooling blood for hemostasis, removing the necrotic tissue and promoting granulation, anti-inflammation have better been reached, contrafluxion, edema are comparatively fast recovered, the healing of local curing ulcer erosion, thus reach therapeutic purposes.Medicine of the present invention, treating both the principal and secondary aspects of a disease, drug effect is rapid, safe and reliable, curative effect is preferable.Show that with 156 routine clinical trials effective percentage reaches 100%.
Testing data:
1, cures mainly: ulcerative colitis.
2, case statistics: treat in 156 examples, male's 108 examples, women's 48 examples, age distribution is: 56 examples below 30 years old, 31～40 years old 36 example, 41～50 years old 32 example, 50～60 years old 20 example, 12 examples more than 60 years old, maximum 63 years old age, minimal ages 20 years old.
3, Therapeutic Method: coloclysis is once just before going to bed every night.10 times is a course of treatment.3～7 days at interval each, but reuse next course of treatment course of treatment.
4, contraindication: period in a medicine, avoid eating anything raw or cold, pungent greasy, stodgy food, do not have a bath with cold water.Anemia of pregnant woman's forbidding is forbidden this product allergy sufferers.
5, efficacy assessment standard:
Produce effects: bloody purulent stool disappears, and stomachache disappears, and it is normal that stool recovers.Take a turn for the better: bloody purulent stool reduces, and stomachache alleviates, and the diarrhoea number of times reduces.Invalid: as not reach improvement target person.
6, therapeutic effect:
The shortest 66 days, the longest 180 days, medication produce effects 86 examples account for 55.13%, and 70 examples that take a turn for the better account for 44.87%, invalid 0 example, total effective rate 100%.
7, model case introduction:
(1) Zhang, the man, 36 years old, live Hua County, Henan Province Jiao Huxiang, stomachache, diarrhoea, bloody purulent stool show effect repeatedly after 3 months, do colonoscopy to the People's Hospital, Anyang, the hyperemia of scope report finding sigmoid colon hypomere mucosa, edema in March, 2007, vasoganglion disappears under the mucosa, in be dispersed in the curing ulcer erosion kitchen range, be diagnosed as ulcerative colitis.Through with above-mentioned therapeutic scheme coloclysis, after 1 course of treatment, bloody purulent stool disappears substantially.Treat 2 courses of treatment, clinical symptom disappearance.For consolidating curative effect, use 3 courses of treatment again, so far not recurrence.
(2) Wei so-and-so, the woman 52 years old, lives the Feng Zhuan of Yanjin County, Henan Province.Fall ill in June, 2008, begins to show as tenesmus, hemafecia once in a while, presses two weeks of internal hemorrhoid treatment, and the state of an illness increases the weight of gradually, changes into bloody purulent stool every day 2～3 times.Do colonoscopy to provincial hospital afterwards, find that mucous membrane of rectum is dispersed in congestion and edema, somewhat flaky erosion and petechia are diagnosed as proctitis.With this medicine enema treatment, 2 the course of treatment clinical symptoms all disappear.After 4 courses of treatment of after treatment again, do not see recurrence so far.
(3) week so-and-so, the woman, 46 years old, live Dongguan, road junction town, Hua County, Henan Province, in March, 2009 morbidity, times of defecation is many, bleeds after an action of the bowels, once in a while stomachache, mucoid stool.It is invalid to press internal hemorrhoid treatment one month, transfers bloody purulent stool to, and it is more and more many to cut number of times, occur obviously weak, anemia.Do colonoscopy in the People's Hospital, Anyang May, sees that mucous membrane of rectum is dispersed in the rotten to the corn kitchen range of lamellar, and mucous hyperemia edema around the focus is diagnosed as proctitis.With this medicine coloclysis, after 2 courses of treatment, the clinical symptoms complete obiteration.Consolidate 4 courses of treatment of medication afterwards again, all are normal for health now.
The specific embodiment:
Below in conjunction with embodiment the present invention is done further narration:
Embodiment 1:a chooses: artificial Calculus Bovis's 3.5 grams, Borneolum Syntheticum 1.8 grams, Margarita 21 grams, Dens Elephatis 21 grams, Indigo Naturalis 91 grams, Uroctea compatilis Koch. (charcoal) 14 grams; Levigation sieves, and mixes, and forms mixed dust formulation A; B gets one of mixed dust formulation A percentage, adds gentamycin 40,000 units, metronidazole liquid 30ml is molten is medicinal liquid.Artificial Calculus Bovis, Borneolum Syntheticum, Margarita, Dens Elephatis, Indigo Naturalis, Uroctea compatilis Koch. (charcoal) are ground into fine powder, cross 100 mesh sieves, mixing through sterilization (disinfection by ultraviolet light, each embodiment is identical), promptly gets mixed dust formulation A; Mixed dust formulation A, gentamycin, metronidazole liquid are placed respectively; During use, again mixed dust formulation A is added celebrating Da Lei element, metronidazole liquid temporarily, make medicinal liquid, in order to retention enema.
Embodiment 2:a chooses: artificial Calculus Bovis's 4.5 grams, Borneolum Syntheticum 2.2 grams, Margarita 25 grams, Dens Elephatis 25 grams, Indigo Naturalis 97 grams, Uroctea compatilis Koch. 18 grams; Levigation sieves, and mixes, and forms mixed dust formulation A; B gets one of mixed dust formulation A percentage, adds gentamycin 80,000 units, metronidazole liquid 50ml is molten is medicinal liquid.Artificial Calculus Bovis, Borneolum Syntheticum, Margarita, Dens Elephatis, Indigo Naturalis, Uroctea compatilis Koch. (charcoal) are ground into fine powder, cross 100 mesh sieves, through sterilization, mixing promptly gets mixed dust formulation A; Mixed dust formulation A, gentamycin, metronidazole liquid are placed respectively; During use, again mixed dust formulation A is added celebrating Da Lei element, metronidazole liquid temporarily, make medicinal liquid, in order to retention enema.
Embodiment 3:a chooses: artificial Calculus Bovis's 3 grams, Borneolum Syntheticum 1.5 grams, Margarita 19 grams, Dens Elephatis 19 grams, Indigo Naturalis 88 grams, Uroctea compatilis Koch. (charcoal) 13 grams; Levigation sieves, and mixes, and forms mixed dust formulation A; B gets Rhizoma Coptidis 10 grams, the Radix Astragali 10 grams, Cortex Phellodendri 10 grams, pulverizes, and adds water 120ml and fries in shallow oil 30～40 minutes, and the 40ml that takes concoction gets one of mixed dust formulation A percentage, is dissolved in this medicine juice, forms medicinal liquid, in order to retention enema.
Embodiment 4:a chooses: artificial Calculus Bovis's 5 grams, Borneolum Syntheticum 2.5 grams, Margarita 27 grams, Dens Elephatis 27 grams, Indigo Naturalis 100 grams, Uroctea compatilis Koch. (charcoal) 19 grams; Levigation sieves, and mixes, and forms mixed dust formulation A; B gets Rhizoma Coptidis 15 grams, the Radix Astragali 15 grams, Cortex Phellodendri 15 grams, pulverizes, and adds water 200ml and fries in shallow oil 30～40 minutes, and the 50ml that takes concoction gets one of mixed dust formulation A percentage, is dissolved in this medicine juice, forms medicinal liquid, in order to retention enema.
Embodiment 5:a chooses: artificial Calculus Bovis's 5 grams, Borneolum Syntheticum 2.5 grams, Margarita 27 grams, Dens Elephatis 27 grams, Indigo Naturalis 100 grams, Uroctea compatilis Koch. (charcoal) 19 grams; Levigation sieves, and mixes, and forms mixed dust formulation A; Get Rhizoma Coptidis 15 grams, the Radix Astragali 15 grams, Cortex Phellodendri 15 grams, pulverize, add water 200ml and fried in shallow oil 30～40 minutes, filtering residue is got one of mixed dust formulation A percentage, adds three yellow liquors, fries in shallow oil 1～5 minute, and the 50ml that takes concoction forms medicinal liquid, in order to retention enema.
Claims (10)
1. medicine for the treatment of ulcerative colitis, it is characterized in that: a chooses the raw material of following weight: artificial Calculus Bovis's 3～5 grams, Borneolum Syntheticum 1.5～2.5 grams, Margarita 19～27 grams, Dens Elephatis 19～27 grams, Indigo Naturalis 88～100 grams, Uroctea compatilis Koch. 13～19 grams; Levigation sieves, and mixes, and forms mixed dust formulation A; B gentamycin 4～80,000 units, metronidazole liquid 30～50ml mix formation celebrating first liquid, get one of mixed dust formulation A percentage, and dissolving in this liquid is medicinal liquid.
2. a kind of medicine for the treatment of ulcerative colitis according to claim 1 is characterized in that: gentamycin refers to that powder, metronidazole refer to powder, and adding distil water 30～50ml mixes formation celebrating first liquid, gets one of mixed dust formulation A percentage, and dissolving in this liquid is medicinal liquid.
3. a kind of medicine for the treatment of ulcerative colitis according to claim 1 is characterized in that: also comprise berberine powder 7～13 grams among the mixed dust formulation A.
4. according to claim 1 or 2 or 3 described a kind of medicines for the treatment of ulcerative colitis, it is characterized in that: mixed dust formulation A and gentamycin powder, metronidazole powder are mixed and made into a kind of of powder or capsule or suppository.
5. a kind of medicine for the treatment of ulcerative colitis according to claim 1 is characterized in that: mixed dust formulation A, gentamycin, metronidazole liquid are placed respectively; During use, in proportion mixed dust formulation A is added celebrating Da Lei element, metronidazole liquid temporarily, make medicinal liquid.
6. a kind of medicine for the treatment of ulcerative colitis according to claim 1, it is characterized in that: the b operation is replaced by following scheme: get Rhizoma Coptidis 10～15 grams, the Radix Astragali 10～15 grams, Cortex Phellodendri 10～15 grams, adding water 100～200ml fried in shallow oil 25～35 minutes, filtering residue, be three yellow liquors, get this liquid 30～50ml; With one of mixed dust formulation A percentage, be dissolved in this liquid and become medicinal liquid.
7. a kind of medicine for the treatment of ulcerative colitis according to claim 1 is characterized in that: keep a operation, cancellation b operation, with Rhizoma Coptidis 10～15 grams, the Radix Astragali 10～15 grams, Cortex Phellodendri 10～15 grams, add water 100～200ml and fried in shallow oil 25～35 minutes, filtering residue is three yellow liquors; Get one of the percentage of the mixed dust formulation A in a operation again, add three yellow liquors, fried in shallow oil 1～5 minute, the 30～50ml that takes concoction becomes medicinal liquid.
8. a kind of medicine for the treatment of ulcerative colitis according to claim 6 is characterized in that: mixed dust formulation A, three yellow liquors are placed respectively; During use, again mixed dust formulation A is added three yellow liquors in proportion, make medicinal liquid.
9. a kind of medicine for the treatment of ulcerative colitis according to claim 1 is characterized in that the component of raw material is: artificial Calculus Bovis's 4 grams, Borneolum Syntheticum 2 grams, Margarita 23 grams, Dens Elephatis 23 grams, Indigo Naturalis 94 grams, Uroctea compatilis Koch. 16 grams.
10. a kind of medicine for the treatment of ulcerative colitis according to claim 6 is characterized in that: final medicinal liquid is made decoction or liquid agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910172794A CN101708203A (en) | 2009-11-30 | 2009-11-30 | Medicament for treating ulcerative colitis |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910172794A CN101708203A (en) | 2009-11-30 | 2009-11-30 | Medicament for treating ulcerative colitis |
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| CN101708203A true CN101708203A (en) | 2010-05-19 |
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| CN200910172794A Pending CN101708203A (en) | 2009-11-30 | 2009-11-30 | Medicament for treating ulcerative colitis |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103505548A (en) * | 2013-06-25 | 2014-01-15 | 江苏七○七天然制药有限公司 | Traditional Chinese medicine used for treating ulcerative colitis, and preparation method and detection method thereof |
| CN104225260A (en) * | 2014-10-14 | 2014-12-24 | 杨华岳 | Enema traditional Chinese medicine powder for ulcerative colitis treatment |
| CN112843130A (en) * | 2021-01-19 | 2021-05-28 | 上海市第十人民医院 | A pharmaceutical composition |
-
2009
- 2009-11-30 CN CN200910172794A patent/CN101708203A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103505548A (en) * | 2013-06-25 | 2014-01-15 | 江苏七○七天然制药有限公司 | Traditional Chinese medicine used for treating ulcerative colitis, and preparation method and detection method thereof |
| CN104225260A (en) * | 2014-10-14 | 2014-12-24 | 杨华岳 | Enema traditional Chinese medicine powder for ulcerative colitis treatment |
| CN104225260B (en) * | 2014-10-14 | 2017-06-16 | 杨华岳 | A kind of bowel lavage traditional Chinese medicine powder for treating ulcerative colitis |
| CN112843130A (en) * | 2021-01-19 | 2021-05-28 | 上海市第十人民医院 | A pharmaceutical composition |
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Open date: 20100519 |