CN104352679A - Capsule for moistening intestines and relaxing bowels and preparation method thereof - Google Patents
Capsule for moistening intestines and relaxing bowels and preparation method thereof Download PDFInfo
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- CN104352679A CN104352679A CN201410686462.3A CN201410686462A CN104352679A CN 104352679 A CN104352679 A CN 104352679A CN 201410686462 A CN201410686462 A CN 201410686462A CN 104352679 A CN104352679 A CN 104352679A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
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- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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Abstract
The invention is suitable for the field of intestinal medical treatment, and provides a capsule for moistening the intestines and relaxing the bowels. The capsule comprises a Chinese herbal medicine extract in the capsule and a capsule shell, wherein the Chinese herbal medicine extract in the capsule comprises raw materials with the following mass proportion relationships: 20-30% of an aloe extract, 10-20% of hemp seed, 25-35% of radish seed, 15-25% of cassia seed and the balance of apricot kernel; and medicinal gelatin comprises the raw materials with the following mass proportion relationships: 3-5% of medicinal gelatin, 1-3% of glycerin, 5-8% of ethanol and 84-91% of purified water. The capsule for moistening the intestines and relaxing the bowels, provided by the invention, is a yellowish and semitransparent capsule, has smooth feeling, cannot generate peculiar smell, has a lubrication effect on internal walls of rectums, and also can be used for softening excrement to ensure that the excrement is easier to defecate; and the capsule has relatively good water solubility, and ensures that no residue is caused after the capsule is used. The capsule provided by the invention is clinically suitable for treatment or adjunctive treatment on inhibited defecation and constipation, does not have medicament resistance, and cannot cause toxic or side effects.
Description
Technical field
The present invention relates to a kind of intestinal Medicines, particularly relate to a kind of capsule for relieving constipation and preparation method thereof.
Background technology
Along with the fast development of society, constipation has become undisputed " popular sick ", and causing a lot of because have of constipation: diet is very few, food is too smart meticulous, and the cellulose in food and moisture content deficiency, can not form a certain amount of stimulation to intestinal, enterokinesia is slow, can not push food debris to rectum in time, at enteral extended residence time, moisture content too much absorbs and makes feces dry.In addition, the large origin cause of formation that the stool time is also constipation is delayed.Some stool be used as unimportant, can early can be slow thing, ignore the custom of timing defecation; Or because of worked busy, nervous, travelling life etc., delay the stool time, make the feces having arrived rectum turn back to colon; Or because suffering from the anus such as anal fissure and hemorrhoid, Fear, Pain, fear hemorrhage, dare not defecate and spin out stool interval time.The pressure experience reaction dull that this produces after the neurocyte on rectal wall all may be made to enter rectum to feces, makes feces not cause defecation to feel at internal rectum extended residence time, the constipation of forming the habit property.
Because social pressure is on the impact of people's life, dietary habit, the morbidity crowd more and more rejuvenation of constipation.The sickness rate of constipation in crowd up to 27%, and has and increases trend.Constipation patient is except feeling not quite the thing, and also likely with mental maladjustment such as insomnia, anxiety, depressions, severe patient there will be stomachache, anemia and the symptom such as to become thin.Because constipation sickness rate is high, the cause of disease is complicated, patient often has manifold vexations, and can affect quality of life when constipation is serious.
The medicine that present medical science is commonly used to treat constipation has two classes, and a class is oral relieving constipation product, and another kind of is external relieving constipation product.Orally taken product must through intestinal absorption, and effect is also not obvious, especially to the patient of insufficiency of the spleen cold syndrome of the stomach, produces little effect especially.Externally applied product mostly is glycerin and similar products thereof, directly acts on anal orifice and rectal intestine more, stimulates intestinal wall, causes defecation to react to reflexive.No matter but be for oral administration or external relieving constipation product, all do not reach good therapeutic effect, and life-time service can make human body produce corresponding Drug tolerance, is not well positioned to meet Clinical practice.
Summary of the invention
This product provides a kind of capsule for relieving constipation, is intended to solve existing Orally taken product and externally applied product zest is strong, aperient effects is bad technical problem.
In order to realize foregoing invention object, a kind of capsule for relieving constipation provided by the invention, comprise the Chinese herbal medicine extract in capsule and gel shell, the raw material of the Chinese herbal medicine extract in described capsule and the relationship between quality of proportioning raw materials: Aloe extract: Fructus Cannabis: Semen Raphani: Semen Cassiae: Semen Armeniacae Amarum=20%-30%:10%-20%:25%-35%:15%-25%; The following pharmagel of relationship between quality of described pharmagel raw material and proportioning raw materials: glycerol: ethanol: purified water=3% ~ 5%: 1% ~ 3%: 5% ~ 8%: 84% ~ 91%.
Preferably, the raw material of the Chinese herbal medicine extract in described capsule and the relationship between quality of proportioning raw materials: 30%:20%:25%:25%; The raw material of pharmagel and the relationship between quality of proportioning raw materials: glycerol: ethanol: purified water=3%: 1%: 5%: 91%.
Preferably, the raw material of the Chinese herbal medicine extract in described capsule and the relationship between quality of proportioning raw materials: 20%:20%:35%:25%; The raw material of pharmagel and the relationship between quality of proportioning raw materials: glycerol: ethanol: purified water=3%: 3%: 5%: 89%.
Preferably, the raw material of the Chinese herbal medicine extract in described capsule and the relationship between quality of proportioning raw materials: 25%:15%:35%:25%; The raw material of pharmagel and the relationship between quality of proportioning raw materials: glycerol: ethanol: purified water=4%: 3%: 7%: 86%.
Preferably, the raw material of described a kind of capsule for relieving constipation and the relationship between quality of proportioning raw materials as follows, the raw material of the Chinese herbal medicine extract in described capsule and the relationship between quality of proportioning raw materials: 30%:10%:35%:25%; The raw material of pharmagel and the relationship between quality of proportioning raw materials: glycerol: ethanol: purified water=5%: 2%: 8%: 85%.
Preferably, described ethanol to be concentration be 95% ethanol.
In addition, present invention also offers the method for above-mentioned capsule for relieving constipation, comprise the steps:
1) Chinese herbal medicine extract in capsule makes granule as gel shell content;
2) purified water is heated to 100 DEG C, adds pharmagel and constantly stir, treating solution mix homogeneously, continue heating and after 15 minutes, stop heating;
3) open cooling device, solution temperature is down to room temperature, namely form capsule;
4) leave standstill final vacuum deaeration, under agitation add ethanol and glycerol to capsule, continue stirring 15 minutes, namely obtain capsule for relieving constipation.
The beneficial effect of the embodiment of the present invention is:
The present invention has prepared capsule for relieving constipation by have employed new formula, and its raw material is all selected from All Pure Nature wild environment, adopts scientific formula, utilize modern crafts to refine to form, to human non-toxic's side effect and harmful effect, not containing any chemical addition agent, can relievedly take.In addition through scientific validation, human body gastrointestinal function and skin can be improved rapidly, long-term taking also can safeguard health, keep skin smooth, fine and smooth flexible, utilize small molecule between material to have the physical phenomenon attracted each other, absorbing toxin, and excrete with human metabolism, whole process, without Liver and kidney metabolism, has no side effect.The molecular structure of its uniqueness and active substance can moisten impaired intestinal mucosa, promote gastrointestinal peristalsis, quick purged body endotoxin and garbage, loosening bowel to relieve constipation, balance internal organs function; Discharge the plumbous hydrargyrum deposit, melanin, toxin and the metabolism rubbish that are hidden in skin bottom; Recover skin cell eubolism, pore refining, compact skin, recovers elasticity, bright color; Regulate skin PH, strengthen skin immunity, thoroughly solve mottle, dull-looking skin, acne, comedo, pachylosis, potbelly, lower abdomen is given prominence to, the problems such as halitosis bitter taste, insomnia.
Pharmagel of the present invention, by glycerol, ethanol and purified water, wherein, pharmagel has the multifrequency natures such as good capsule, solid water, cohesive and dissolubility, and higher change purity, as slow-release material; Glycerol has good water absorption, can dissolve with water with any ratio, and the glycerite of low concentration can do lubricating oil and moisten skin; Ethanol is well a kind of
solvent, can dissolve many
inorganic matter, many Organic substances can be dissolved again, and there is stronger osmosis.A kind of capsule for relieving constipation provided by the invention is the translucent capsule of micro-yellow, has soapy feeling, free from extraneous odour.Capsule for relieving constipation can form layer protecting film at impaired blood stasis position, effectively isolates, avoids environmental stimuli, thus reach the effect reducing blood stasis, alleviating pain, elimination hemorrhoid clinical symptoms with internal rectum rugged environment.
Capsule for relieving constipation has lubrication to inner walls of rectums, and can soften stool, and stool is more easily discharged, and capsule itself has good water solublity, ensure that noresidue after using.This product is clinical to be applicable to defecate the treatment of not smooth and constipation or auxiliary treatment.
Detailed description of the invention
For a better understanding of the present invention, set forth content of the present invention further below in conjunction with implementing, but content of the present invention is not only confined to the following examples.
Embodiment 1:
A kind of capsule for relieving constipation, described capsule for relieving constipation comprises pharmagel, glycerol, ethanol and purified water.The raw material of described a kind of capsule for relieving constipation and the relationship between quality of proportioning raw materials as follows, pharmagel: glycerol: ethanol: purified water=3%: 1%: 5%: 91%.
Embodiment 2:
A kind of capsule for relieving constipation, described capsule for relieving constipation comprises pharmagel, glycerol, ethanol and purified water.The raw material of described a kind of capsule for relieving constipation and the relationship between quality of proportioning raw materials as follows, pharmagel: glycerol: ethanol: purified water=3%: 1%: 8%: 88%.
Embodiment 3:
A kind of capsule for relieving constipation, described capsule for relieving constipation comprises pharmagel, glycerol, ethanol and purified water.The raw material of described a kind of capsule for relieving constipation and the relationship between quality of proportioning raw materials as follows, pharmagel: glycerol: ethanol: purified water=3%: 3%: 5%: 89%.
Embodiment 4:
A kind of capsule for relieving constipation, described capsule for relieving constipation comprises pharmagel, glycerol, ethanol and purified water.The raw material of described a kind of capsule for relieving constipation and the relationship between quality of proportioning raw materials as follows, pharmagel: glycerol: ethanol: purified water=3%: 3%: 5%: 89%.
Embodiment 5:
A kind of capsule for relieving constipation, described capsule for relieving constipation comprises pharmagel, glycerol, ethanol and purified water.The raw material of described a kind of capsule for relieving constipation and the relationship between quality of proportioning raw materials as follows, pharmagel: glycerol: ethanol: purified water==4%: 3%: 7%: 86%.
Above-mentioned capsule for relieving constipation takes points for attention:
1, period in a medicine avoid eating anything raw or cold, pungent greasy thing.
2, take this product should not take containing Rhizoma et radix veratri (Radix Rhizoma Veratri), Oletum Trogopterori, Fructus Gleditsia or its preparation simultaneously, should not have tea and eat Radix Raphani in order to avoid affect drug effect.
3, allergic constitution person is cautious use of.
4, child and anemia of pregnant woman weakling, forbid taking.
5, forbid when property of drug changes taking.
6, please this medicine is placed on the place that child can not contact.
Concrete preparation method as follows:
Neck material person takes pharmagel, glycerol, ethanol and purified water with concrete formula, takes purified water and puts into GT6JC (200L) type jacketed pan, covered tightly by pot cover by formula proportion.The heating temperature control of jacketed pan is set as 100 DEG C, heating temperature control is also set as 100 DEG C, heat temperature raising, when water temperature rises to 100 DEG C, be sequentially added into the pharmagel taken, constantly stir makes pharmagel dissolve completely simultaneously, continue stirring 15 minutes, make the abundant mix homogeneously of solution, continue heat and keep solution temperature to be 100 DEG C, after 15 minutes, stop heating, and open cooling water, after temperature drops to room temperature, namely capsule is formed, leave standstill final vacuum deaeration, in capsule, under agitation first add ethanol and glycerol continue to stir 15min and namely obtain capsule for relieving constipation.(remarks: whole process for preparation must complete in 2 hours)
Clinical verification is carried out to the aperient effects of the capsule for relieving constipation that the embodiment of the present invention provides below.
The object of this test is verify that capsule for relieving constipation and other drug are to the other therapeutic effect to have blood in stool, the fall symptoms such as pain, prolapsus.120 patients are divided into two groups below, experimental group and each 60 people of matched group.
Experimental group: use capsule for relieving constipation to patient, once-a-day, each 10ml, uses before sleeping.
Matched group: glycerin and oral viable bacteria class medicine are used to patient, three times on the one, each one.
Above two groups, administration time is one week
result of clinical detection before and after medication:
clinical effectiveness after medication:
| Group | Patient's number | Cure rate ﹪ | Obvious effective rate ﹪ | Total effective rate ﹪ |
| Tongbian capsule | 60 | 65 | 23.33 | 88.33 |
| Matched group | 60 | 23.68 | 31.33 | 55.01 |
Compare after treatment, two groups of cure rates, obvious effective rate, effective percentage no difference of science of statistics (P > 0.05), two groups all take an evident turn for the better to the curative effect of all kinds of symptom of constipation, but from result of the test, the cure rate having tried out capsule for relieving constipation is better than matched group.
Claims (6)
1. a capsule for relieving constipation, it is characterized in that: comprise the Chinese herbal medicine extract in capsule and gel shell, the raw material of the Chinese herbal medicine extract in described capsule and the relationship between quality of proportioning raw materials: Aloe extract: Fructus Cannabis: Semen Raphani: Semen Cassiae: Semen Armeniacae Amarum=20%-30%:10%-20%:25%-35%:15%-25%; The following pharmagel of relationship between quality of described pharmagel raw material and proportioning raw materials: glycerol: ethanol: purified water=3% ~ 5%: 1% ~ 3%: 5% ~ 8%: 84% ~ 91%.
2. a kind of capsule for relieving constipation according to claim 1, is characterized in that: the raw material of the Chinese herbal medicine extract in described capsule and the relationship between quality of proportioning raw materials: 30%:20%:25%:25%; The raw material of pharmagel and the relationship between quality of proportioning raw materials: glycerol: ethanol: purified water=3%: 1%: 5%: 91%.
3. a kind of capsule for relieving constipation according to claim 1, is characterized in that: the raw material of the Chinese herbal medicine extract in described capsule and the relationship between quality of proportioning raw materials: 20%:20%:35%:25%; The raw material of pharmagel and the relationship between quality of proportioning raw materials: glycerol: ethanol: purified water=3%: 3%: 5%: 89%.
4. a kind of capsule for relieving constipation according to claim 1, is characterized in that: the raw material of the Chinese herbal medicine extract in described capsule and the relationship between quality of proportioning raw materials: 25%:15%:35%:25%; The raw material of pharmagel and the relationship between quality of proportioning raw materials: glycerol: ethanol: purified water=4%: 3%: 7%: 86%.
5. a kind of capsule for relieving constipation according to claim 1, is characterized in that: the raw material of the Chinese herbal medicine extract in described capsule and the relationship between quality of proportioning raw materials: 30%:10%:35%:25%; The raw material of pharmagel and the relationship between quality of proportioning raw materials: glycerol: ethanol: purified water=5%: 2%: 8%: 85%.
6., according to the preparation method of the arbitrary described capsule for relieving constipation of claim 1-5, it is characterized in that comprising the steps:
1) Chinese herbal medicine extract in capsule makes granule as gel shell content;
2) purified water is heated to 100 DEG C, adds pharmagel and constantly stir, treating solution mix homogeneously, continue heating and after 15 minutes, stop heating;
3) open cooling device, solution temperature is down to room temperature, namely form capsule;
4) leave standstill final vacuum deaeration, under agitation add ethanol and glycerol to capsule, continue stirring 15 minutes, namely obtain capsule for relieving constipation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410686462.3A CN104352679A (en) | 2014-11-26 | 2014-11-26 | Capsule for moistening intestines and relaxing bowels and preparation method thereof |
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| CN201410686462.3A CN104352679A (en) | 2014-11-26 | 2014-11-26 | Capsule for moistening intestines and relaxing bowels and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105341890A (en) * | 2015-11-17 | 2016-02-24 | 广东红珊瑚药业有限公司 | Health food possessing bowel-relaxing effect and preparation method thereof |
| CN105362733A (en) * | 2015-10-29 | 2016-03-02 | 陈光辉 | Drug for treating constipation |
| CN108902957A (en) * | 2018-07-19 | 2018-11-30 | 深圳市博奥生物科技有限公司 | A kind of capsule for relieving constipation and preparation method thereof |
| CN109381454A (en) * | 2018-10-19 | 2019-02-26 | 济川药业集团有限公司 | A kind of capsule for relieving constipation and preparation method thereof |
| CN112336921A (en) * | 2019-08-08 | 2021-02-09 | 英诺美生物科技股份有限公司 | Capsules for preserving lubricants |
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| JPS6037960A (en) * | 1983-08-10 | 1985-02-27 | Osaka Chem Lab | Health drink |
| CN101331947A (en) * | 2008-06-12 | 2008-12-31 | 东莞锦泰食品有限公司 | Cookies formula with catharsis effect and preparation method thereof |
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2014
- 2014-11-26 CN CN201410686462.3A patent/CN104352679A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6037960A (en) * | 1983-08-10 | 1985-02-27 | Osaka Chem Lab | Health drink |
| CN101331947A (en) * | 2008-06-12 | 2008-12-31 | 东莞锦泰食品有限公司 | Cookies formula with catharsis effect and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 张德志: "《药学概论》", 31 January 2011, 中国医药科技出版社 * |
| 环球医药网: "解秘胶囊", 《HTTP://WWW.QGYYZS.NET/BUSINESS/ZS280246.HTM#》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362733A (en) * | 2015-10-29 | 2016-03-02 | 陈光辉 | Drug for treating constipation |
| CN105341890A (en) * | 2015-11-17 | 2016-02-24 | 广东红珊瑚药业有限公司 | Health food possessing bowel-relaxing effect and preparation method thereof |
| CN108902957A (en) * | 2018-07-19 | 2018-11-30 | 深圳市博奥生物科技有限公司 | A kind of capsule for relieving constipation and preparation method thereof |
| CN109381454A (en) * | 2018-10-19 | 2019-02-26 | 济川药业集团有限公司 | A kind of capsule for relieving constipation and preparation method thereof |
| CN109381454B (en) * | 2018-10-19 | 2020-10-13 | 济川药业集团有限公司 | Capsule for relaxing bowel and preparation method thereof |
| CN112336921A (en) * | 2019-08-08 | 2021-02-09 | 英诺美生物科技股份有限公司 | Capsules for preserving lubricants |
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Application publication date: 20150218 |