CN103007046B - Coloclysis liquid capable of preventing intestinal diseases, and application thereof - Google Patents
Coloclysis liquid capable of preventing intestinal diseases, and application thereof Download PDFInfo
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- CN103007046B CN103007046B CN201210569198.6A CN201210569198A CN103007046B CN 103007046 B CN103007046 B CN 103007046B CN 201210569198 A CN201210569198 A CN 201210569198A CN 103007046 B CN103007046 B CN 103007046B
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Abstract
The invention relates to a coloclysis liquid capable of preventing intestinal diseases, and an application thereof, and belongs to the technical field of the coloclysis liquid. The coloclysis liquid comprises 46-69% of a traditional Chinese medicine liquid, 3-11% of probiotics, 2-9% of synergistic ingredients and 20-36% of normal saline. The coloclysis liquid capable of preventing intestinal diseases, and a preparation method and the application thereof can well meet nutrients required by growth of intestinal probiotics by using natural Chinese medicinal herbs as active ingredients and vectors and adding probiotics and nutrient substances required by survival of the probiotics; can relieve constipation, expel stools and intestinal toxins, mitigate and prevent ulcerative rectitis from happening because various components capable of eliminating necrotic tissues and promoting granulation, clearing heat and removing toxicity and diminishing inflammation and stopping bleeding; have a good coloclysis effect, and can make intestinal flora return to normal rapidly. The coloclysis liquid is simple and easy to product, is safe and non-toxic, is convenient for use, and has no side effects during a usage process.
Description
Technical field
The invention belongs to enema technical field, be specifically related to enema of a kind of prevention of intestinal tract disease and uses thereof.
Background technology
Enema is a kind of liquid that pours into human body intestinal canal by casing flusher.Mainly be divided at present four classes: the first kind: clear water class, only there is cleaning function of intestinal canal, get rid of the effect of stool and toxin.As warm water, mineral water etc.Equations of The Second Kind: lubricated defecating feces excretion, this class I liquid I can stimulate intestinal to shrink, and reaches the effect of constipation relieving constipation.As the enema of glycerol composition, glycerin, also has soap lye etc.The 3rd class: extra-nutrition degree of depth toxin expelling class, this class enema can supplement the nutrients to intestinal, after being absorbed, can promote bile secretion, reaches the effect that the degree of depth is got rid of septicemia element, can also form a kind of protecting film at intestinal inwall.The enema of this composition is as the Ai Yuan hall toxin expelling elite of Aloe composition, and the happy clyster powder of fitness of coffee Main Ingredients and Appearance, is a kind of edible composition mostly.Human body is free from side effects completely.The 4th class: be Chinese medicine class, the enema of this class, is mainly to clean administration after intestinal, treatment pelvic inflammatory disease, the intestinal tract diseases such as colitis, as blood stasis-eliminating and stagnation-dissipating enema etc.
Coloclysis is to insert colon perfusion liquid with conduit from anus per rectum, to reach the Therapeutic Method of relieving constipation aerofluxus.Can stimulate enterokinesia, softening, remove feces, and have cooling, hasten parturition, dilute enteral poisonous substance, reduce the effect absorbing.In addition, also can reach therapeutic purposes such as supplying with medicine, nutrition, moisture.Herbal enema method refers to utilize Chinese medicine decoction, pours into rectum colon from anus, makes the medicine sick institute that goes directly, and medicinal liquid is retained in intestinal, is absorbed and is reached various diseases treatment and prevent object by intestinal mucosa.Its long history, see the earliest the treatise on Febrile Diseases of Zhang Zhongjing, later age, medical book also had a lot of relevant records, and as Dunhuang Post famous Paper, Tibetan medicine's masterpiece Four-Volume Medical Code, Prescriptions Worth Thousand Gold for Emergencies, Golden Mirror of Medicine etc., the doctor of visible Ancient Times in China can use clysmata well.Modern medicine is through the further investigation to large intestine, colon physiological function, and this ancient therapy receives people's concern again.
Proctitis ulcerosa belongs to inflammatory bowel, and taking the intestinal ulcer that repeatedly occurs as feature, clinical manifestation is diarrhoea, mucosanguineous feces and stomachache, often outbreak repeatedly, causes severe complication, and treatment difficulty has become clinical treatment
A difficult problem.Improvement herbal retention enema method can be avoided the first pass effect of liver, can make blood drug level stable at mesentery, portal system, not only reaches the effect of topical therapeutic, and has avoided general toxic and side effects.Can apply preferably clinically at present it and treat the intestinal disease of bursting.The employing ameliorative herbal enema method such as Wang Jingfeng finds that patient's local sign and clinical symptoms all has clear improvement after two courses for the treatment of.Zhang Minglan now improves herbal enema method and also can change patient's symptom, and the relapse rate after treatment reduces simultaneously, adverse reaction reduction.Chen Yanmin etc. find that by observation analysis ameliorative herbal enema method can extend the retention time of medicinal liquid in intestinal, reduce the excessive of medicinal liquid, thereby total effective rate is obviously increased.Therefore, the routed intestinal proctitis clinic of herbal enema method treatment is promoted.But in actual applications, still there are some problems, as because sample size is little, experimental program design is unreasonable etc. causes filtering out better prescription.In sum, in the process of application herbal enema method, we should break through conventional frame, give full play to the advantage of Chinese medicine, constantly improve the effect of the routed intestinal proctitis of herbal enema method treatment.
Summary of the invention
For the above-mentioned problems in the prior art, the object of the invention is to design provides the technical scheme of enema of a kind of prevention of intestinal tract disease and uses thereof, its safety non-toxic, and simple and effective, easy to use, with low cost, effect is good.
The enema of described a kind of prevention of intestinal tract disease, is characterized in that adopting following methods preparation:
1) take the following material of weight percentage: herb liquid 46-69%, probiotic bacteria 3-11%, synergistic component 2-9%, normal saline 20-36%;
Described herb liquid adopts following methods preparation: Radix Notoginseng, the Pseudobulbus Bletillae (Rhizoma Bletillae), charred Radix Sanguisorbae, Rhizoma Coptidis, the Radix Angelicae Sinensis of getting equivalent add 4-6 doubly to the water soaking 1-3h of total medical material weight, then at 85-100 DEG C, decoct 25-35min, finally remove by filter medicinal residues, collect filtrate, for subsequent use;
Described probiotic bacteria is one or more mixture in clostridium butyricum, bacillus subtilis, bacillus bifidus, lactobacillus, streptococcus, bacteroid, Eubacterium;
Described synergistic component is one or more mixture in vitamin B2, stachyose;
2) step 1) gained herb liquid, synergistic component, normal saline mixed dissolution is even, 120-150 DEG C of sterilizing 10-20min, finally adds probiotic bacteria, mix homogeneously, packaging enema.
The enema of described a kind of prevention of intestinal tract disease, is characterized in that the content of described herb liquid is 51-67%, is preferably 54-60%.
The enema of described a kind of prevention of intestinal tract disease, the content that it is characterized in that described probiotic bacteria is 5-10%, preferably 6-9%.
The enema of described a kind of prevention of intestinal tract disease, is characterized in that the content of described synergistic component is 3-8%, is preferably 4-6%.
The enema of described a kind of prevention of intestinal tract disease, is characterized in that the content of described normal saline is 23-35%, is preferably 26-31%.
The application that the enema of described a kind of prevention of intestinal tract disease is prevented and treated proctitis ulcerosa, constipation, had blood in stool in preparation in preparation.
Enema of above-mentioned a kind of prevention of intestinal tract disease and uses thereof, taking natural Chinese herbal medicine as active component with carrier, add probiotic bacteria and the probiotic bacteria required nutrient substance of surviving, be well positioned to meet the required nutriment of growth of beneficial bacteria of intestinal tract, contain removing the necrotic tissue and promoting granulation simultaneously, heat-clearing and toxic substances removing, the various compositions of anti-inflammation hemostasia, energy constipation relieving, discharge stool and enterotoxin, alleviate and prevent the generation of proctitis ulcerosa, and enema effect is good, can make intestinal microbial population recover rapidly normal, this enema is produced easy, safety non-toxic, easy to use, use procedure is without any side effects.
The percentage composition relating in present specification unless otherwise indicated, other be weight percentage.
Detailed description of the invention
Below by specific embodiment, the invention will be further described, and further illustrate beneficial effect of the present invention in conjunction with the test of pesticide effectiveness.
Embodiment 1
Take 10.8kg Radix Notoginseng, the 10.8kg Pseudobulbus Bletillae (Rhizoma Bletillae), 10.8kg charred Radix Sanguisorbae, 10.8kg Rhizoma Coptidis and 10.8kg Radix Angelicae Sinensis are put into clean container, add 270kg water soaking 1h, then at 85 DEG C, decoct 25min, refilter and remove medicinal residues, collect filtrate and become herb liquid, then in 100L stirred tank, drop into 54kg herb liquid, add again 3kg vitamin B2 and 3kg stachyose, after stirring and dissolving, add again 31kg normal saline, mixed dissolution is even, 120 DEG C of sterilizing 10min, finally add 1kg clostridium butyricum, 1kg bacillus subtilis, 1kg bacillus bifidus, 1kg lactobacillus, 1kg streptococcus, 1kg bacteroid and 3kg Eubacterium, stir, final products.
Embodiment 2
Take 12.8kg Radix Notoginseng, the 12.8kg Pseudobulbus Bletillae (Rhizoma Bletillae), 12.8kg charred Radix Sanguisorbae, 12.8kg Rhizoma Coptidis and 12.8kg Radix Angelicae Sinensis and put into clean container, add 320kg water soaking 3h, then at 100 DEG C, decoct 35min, refilter and remove medicinal residues, collect filtrate and become herb liquid, then in 100L stirred tank, drop into 64kg herb liquid, add again 4kg vitamin B2, after stirring and dissolving, add again 26kg normal saline, mixed dissolution is even, and 130 DEG C of sterilizing 13min finally add 2kg lactobacillus, 2kg streptococcus and 2kg Eubacterium, stir, final products.
Embodiment 3
Take 11.4kg Radix Notoginseng, the 11.4kg Pseudobulbus Bletillae (Rhizoma Bletillae), 11.4kg charred Radix Sanguisorbae, 11.4kg Rhizoma Coptidis and 11.4kg Radix Angelicae Sinensis and put into clean container, add 285kg water soaking 1.5h, then at 90 DEG C, decoct 28min, refilter and remove medicinal residues, collect filtrate and become herb liquid, then in 100L stirred tank, drop into 57kg herb liquid, add again 5kg stachyose, after stirring and dissolving, add again 30kg normal saline, mixed dissolution is even, and 140 DEG C of sterilizing 18min finally add 4kg clostridium butyricum and 4kg Eubacterium, stir, final products.
Embodiment 4
Take 12.2kg Radix Notoginseng, the 12.2kg Pseudobulbus Bletillae (Rhizoma Bletillae), 12.2kg charred Radix Sanguisorbae, 12.2kg Rhizoma Coptidis and 12.2kg Radix Angelicae Sinensis are put into clean container, add 305kg water soaking 2h, then at 95 DEG C, decoct 30min, refilter and remove medicinal residues, collect filtrate and become herb liquid, then in 100L stirred tank, drop into 61kg herb liquid, add again 1.5kg vitamin B2 and 3kg stachyose, after stirring and dissolving, add again 27kg normal saline, mixed dissolution is even, 150 DEG C of sterilizing 20min, finally add 1.5kg bacillus subtilis, 3kg bacillus bifidus and 3kg lactobacillus, stir, final products.
Embodiment 5
Take 12kg Radix Notoginseng, the 12kg Pseudobulbus Bletillae (Rhizoma Bletillae), 12kg charred Radix Sanguisorbae, 12kg Rhizoma Coptidis and 12kg Radix Angelicae Sinensis are put into clean container, add 300kg water soaking 2.5h, then at 87 DEG C, decoct 32min, refilter and remove medicinal residues, collect filtrate and become herb liquid, then in 100L stirred tank, drop into 60kg herb liquid, add again 2.2kg vitamin B2 and 2kg stachyose, after stirring and dissolving, add again 28.8kg normal saline, mixed dissolution is even, 125 DEG C of sterilizing 12min, finally add 1kg clostridium butyricum, 2kg bacillus subtilis, 2kg lactobacillus and 2kg bacteroid, stir, final products.
Embodiment 6
Take 11.6kg Radix Notoginseng, the 11.6kg Pseudobulbus Bletillae (Rhizoma Bletillae), 11.6kg charred Radix Sanguisorbae, 11.6kg Rhizoma Coptidis and 11.6kg Radix Angelicae Sinensis and put into clean container, add 290kg water soaking 2.8h, then at 97 DEG C, decoct 34min, refilter and remove medicinal residues, collect filtrate and become herb liquid, then in 100L stirred tank, drop into 58kg herb liquid, add again 5.3kg stachyose, after stirring and dissolving, add again 29.4kg normal saline, mixed dissolution is even, and 135 DEG C of sterilizing 15min finally add 2.3kg bacillus subtilis and 5kg bacillus bifidus, stir, final products.
The excellent results of above-mentioned enema formula is below described by test.
Test 1:
Proctitis ulcerosa is selected respectively in each processing, the sufferer of having blood in stool 25 examples are tested, get the enema 100ml of embodiment 1-6 gained, respectively at the retention enema of the stool of emptying just before going to bed, more than medicinal liquid retains 3h at least in vivo, if discharge and need repetition to operate above coloclysis 100ml again lower than 3h.Test and carry out enteroscopy after 15 days, statistics recovery from illness, effective, effective, invalid sufferer number, calculate its total effective rate (%).Criterion of therapeutical effect: 1. recovery from illness: the report of intestinal mirror shows that ulcer surface disappears, the transference cure of having blood in stool.2. effective: the report of intestinal mirror shows that ulcer surface dwindles, and has had blood in stool and has alleviated significantly.3. effective: intestinal mirror report show ulcer, the symptom of having blood in stool have to a certain degree alleviate but not too obvious.4. invalid: the report of intestinal mirror shows that ulcer, the symptom of having blood in stool do not alleviate or increase the weight of.Result of the test is in table 1.
Table 1 embodiment 1-6 is to proctitis ulcerosa, the effect table of having blood in stool
| Process | Sufferer (example) | Recovery from illness | Effective | Effectively | Invalid | Total effective rate (%) |
| Embodiment 1 | 25 | 7 | 15 | 3 | 0 | 100 |
| Embodiment 2 | 25 | 10 | 13 | 2 | 0 | 100 |
| Embodiment 3 | 25 | 8 | 14 | 3 | 0 | 100 |
| Embodiment 4 | 25 | 9 | 14 | 2 | 0 | 100 |
| Embodiment 5 | 25 | 9 | 13 | 3 | 0 | 100 |
| Embodiment 6 | 25 | 10 | 15 | 0 | 0 | 100 |
Result of the test shows: embodiment 1-6 to proctitis ulcerosa, having blood in stool all has good curative effect, embodiment 2 is better than embodiment 1, embodiment 4 is better than embodiment 3, embodiment 6 is better than embodiment 5.
Claims (10)
1. an enema for prevention of intestinal tract disease, is characterized in that adopting following methods preparation:
1) take the following material of weight percentage: herb liquid 46-69%, probiotic bacteria 3-11%, synergistic component 2-9%, normal saline 20-36%;
Described herb liquid adopts following methods preparation: Radix Notoginseng, the Pseudobulbus Bletillae (Rhizoma Bletillae), charred Radix Sanguisorbae, Rhizoma Coptidis, the Radix Angelicae Sinensis of getting equivalent add 4-6 doubly to the water soaking 1-3h of total medical material weight, then at 85-100 DEG C, decoct 25-35min, finally remove by filter medicinal residues, collect filtrate, for subsequent use;
Described probiotic bacteria is the mixture of clostridium butyricum, bacillus subtilis, bacillus bifidus, lactobacillus, streptococcus, bacteroid and Eubacterium;
Described synergistic component is the mixture of vitamin B2 and stachyose;
2) step 1) gained herb liquid, synergistic component, normal saline mixed dissolution is even, 120-150 DEG C of sterilizing 10-20min, finally adds probiotic bacteria, mix homogeneously, packaging enema.
2. the enema of a kind of prevention of intestinal tract disease as claimed in claim 1, the content that it is characterized in that described herb liquid is 51-67%.
3. the enema of a kind of prevention of intestinal tract disease as claimed in claim 1, the content that it is characterized in that described herb liquid is 54-60%.
4. the enema of a kind of prevention of intestinal tract disease as claimed in claim 1, the content that it is characterized in that described probiotic bacteria is 5-10%.
5. the enema of a kind of prevention of intestinal tract disease as claimed in claim 1, the content that it is characterized in that described probiotic bacteria is 6-9%.
6. the enema of a kind of prevention of intestinal tract disease as claimed in claim 1, the content that it is characterized in that described synergistic component is 3-8%.
7. the enema of a kind of prevention of intestinal tract disease as claimed in claim 1, the content that it is characterized in that described synergistic component is 4-6%.
8. the enema of a kind of prevention of intestinal tract disease as claimed in claim 1, the content that it is characterized in that described normal saline is 23-35%.
9. the enema of a kind of prevention of intestinal tract disease as claimed in claim 1, the content that it is characterized in that described normal saline is 26-31%.
10. the application that the enema of a kind of prevention of intestinal tract disease as claimed in claim 1 is prevented and treated proctitis ulcerosa, constipation, had blood in stool in preparation in preparation.
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| CN104644829A (en) * | 2014-06-10 | 2015-05-27 | 陈莉芬 | Antidiarrheal medicine |
| CN104857026A (en) * | 2015-05-18 | 2015-08-26 | 新乡医学院 | Method for researching preventive effect of combined clostridium butyricum and bifidobacterium powder on NEC (neonatal necrotizing enterocolitis) |
| CN108815607A (en) * | 2018-04-02 | 2018-11-16 | 云南中京国建投资有限公司 | A kind of gut washout method and apparatus |
| CN110403966A (en) * | 2018-04-28 | 2019-11-05 | 珠海岐微生物科技有限公司 | Radix Angelicae Sinensis notoginseng composition and its purposes in adjusting enteric microorganism |
| CN109223849A (en) * | 2018-08-10 | 2019-01-18 | 江汉大学 | A kind of Chinese cabbage freeze-dried powder enema and its preparation method and application |
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