CN109223849A - A kind of Chinese cabbage freeze-dried powder enema and its preparation method and application - Google Patents

A kind of Chinese cabbage freeze-dried powder enema and its preparation method and application Download PDF

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CN109223849A
CN109223849A CN201810909831.9A CN201810909831A CN109223849A CN 109223849 A CN109223849 A CN 109223849A CN 201810909831 A CN201810909831 A CN 201810909831A CN 109223849 A CN109223849 A CN 109223849A
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chinese cabbage
dried powder
vitamin
enema
freeze
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凌智群
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Jianghan University
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Jianghan University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/375Ascorbic acid, i.e. vitamin C; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745Bifidobacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/062Ascomycota
    • A61K36/064Saccharomycetales, e.g. baker's yeast
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0031Rectum, anus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Natural Medicines & Medicinal Plants (AREA)
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  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
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  • Alternative & Traditional Medicine (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention discloses a kind of Chinese cabbage freeze-dried powder enemas and its preparation method and application, belong to field of health care products.The raw material of the Chinese cabbage freeze-dried powder enema includes: Chinese cabbage freeze-dried powder, vitamin, probiotics, glutamine and dispersing agent, vitamin is at least one of vitamin C and vitamin C salt, Chinese cabbage freeze-dried powder, vitamin, probiotics, glutamine and dispersing agent parts by weight be respectively 10~100 parts, 3~20 parts, 1~30 part, 0.1~6 part and 1000 parts.Glutamine in the Chinese cabbage freeze-dried powder enema has intestinal mucosa protective effect; probiotics has the function of intestinal flora; Chinese cabbage freeze-dried powder effervescent tablet dietary fiber rich in, vitamin and mineral; a large amount of dietary fiber can promote the wriggling of stomach and intestine in Chinese cabbage freeze-dried powder; the synergistic effect of Chinese cabbage freeze-dried powder and vitamin can increase the tolerance of human body to the greatest extent; influence of the hypertonic solution to body is reduced, there is intestines problem health functions of preventing and treating.

Description

A kind of Chinese cabbage freeze-dried powder enema and its preparation method and application
Technical field
The present invention relates to field of health care products, in particular to a kind of Chinese cabbage freeze-dried powder enema and its preparation method and application.
Background technique
Bowel lavage is clinically common treatment means and medication, as cleansing enema uses a large amount of suds or physiology more Coloclysis is repeated in salt water, to thoroughly remove remaining excrement in colon.
Intestines be from stomach pylorus into the digest tube of anus longest one section and most important one section of function.Intestines include small Intestines and large intestine, wherein small intestine includes duodenum, jejunum and ileum;Large intestine includes caecum, colon and rectum.A large amount of digestion Effect and the absorption of almost all digestion product are carried out in small enteral, and the main emergenoy ration residue of large intestine forms excrement, It is excreted again by rectum per anum.Clinically, usually in the narrow enteric cavity of duodenum Yu large intestine junction, this A position is usually ignored by people, and the swill residence time is too long and leads to damage of certain toxin to body, to cause A variety of intestines problems, or even canceration can be caused.Therefore, swill can be shortened in this residence time by needing a kind of substance, To reduce damage of the toxin to body, intestines problem is avoided.
Summary of the invention
The embodiment of the invention provides a kind of Chinese cabbage freeze-dried powder enema and its preparation method and application, Chinese cabbage freeze-dried powder is filled Intestines agent is for preventing and treating intestines problem.The technical solution is as follows:
On the one hand, the embodiment of the invention provides a kind of Chinese cabbage freeze-dried powder enema, the Chinese cabbage freeze-dried powder enema Raw material includes: Chinese cabbage freeze-dried powder, vitamin, probiotics, glutamine and dispersing agent, and the vitamin is vitamin C and Wei Sheng At least one of plain celite, the Chinese cabbage freeze-dried powder, the vitamin, the probiotics, the glutamine and the dispersion The parts by weight of agent are respectively 10~100 parts, 3~20 parts, 1~30 part, 0.1~6 part and 1000 parts.
Specifically, the probiotics is at least one of Bifidobacterium, lactic acid bacteria and saccharomycete.
Specifically, when vitamin C salt is vitamin C and vitamin C salt, the vitamin C and the vitamin C salt Mass ratio is (3:7)~(7:3).
Specifically, the dispersing agent is isotonic solution.
Further, the isotonic solution is inorganic salt solution, and the inorganic salts in the inorganic salt solution are alkali metal sulphur Hydrochlorate, alkali earth metal sulfate, sodium chloride, potassium chloride, sodium bicarbonate and alkali metal sulfates and alkali earth metal sulfate At least one of mixture.
Specifically, the vitamin C salt is vitamine C sodium.
On the other hand, the embodiment of the invention provides a kind of preparation method of Chinese cabbage freeze-dried powder enema, the systems Preparation Method includes:
After mixing by the raw material of the Chinese cabbage freeze-dried powder enema, the Chinese cabbage freeze-dried powder enema is obtained.
Specifically, the osmotic pressure of dispersing agent is 300~700mOsmol/L.
Specifically, the Chinese cabbage freeze-dried powder is freeze-dried powder containing Chinese cabbage or Chinese cabbage freeze-dried powder.
Another aspect, the embodiment of the invention provides the application of the Chinese cabbage freeze-dried powder enema described in one kind, the applications It include: the Chinese cabbage freeze-dried powder enema for preventing and treating intestines problem.
Technical solution provided in an embodiment of the present invention has the benefit that the paddy ammonia in the Chinese cabbage freeze-dried powder enema Amide has intestinal mucosa protective effect, and probiotics has the function of intestinal flora, Chinese cabbage freeze-dried powder effervescent tablet meals rich in Fiber, vitamin and mineral are eaten, a large amount of dietary fiber can promote the wriggling of intestines in Chinese cabbage freeze-dried powder, can help to dilute, The synergistic effect of toxin in excretion enteron aisle, Chinese cabbage freeze-dried powder and vitamin can increase the tolerance of human body to the greatest extent, subtract Few influence of the hypertonic solution to body, has intestines problem health functions of preventing and treating.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, embodiment of the present invention will be made into one below Step ground detailed description.
The embodiment of the invention provides a kind of Chinese cabbage freeze-dried powder enema, the raw material of Chinese cabbage freeze-dried powder enema includes: white Dish freeze-dried powder, vitamin, probiotics, glutamine and dispersing agent, vitamin are at least one in vitamin C and vitamin C salt Kind, Chinese cabbage freeze-dried powder, vitamin, probiotics, glutamine and dispersing agent parts by weight be respectively 10~100 parts, 3~20 parts, 1 ~30 parts, 0.1~6 part and 1000 parts.
Specifically, when vitamin is vitamin C and vitamin C salt, the mass ratio of vitamin C and vitamin C salt be (3: 7)~(7:3).
Specifically, probiotics is at least one of Bifidobacterium, lactic acid bacteria and saccharomycete.
Specifically, dispersing agent can be isotonic solution.
Further, isotonic solution can be inorganic salt solution, the inorganic salts in inorganic salt solution be alkali metal sulfates, The mixture of alkali earth metal sulfate, sodium chloride, potassium chloride, sodium bicarbonate and alkali metal sulfates and alkali earth metal sulfate At least one of.When realizing, alkali metal sulfates can be sodium sulphate or potassium sulfate, and alkali earth metal sulfate can be sulphur Sour magnesium or calcium sulfate.
Specifically, vitamin C salt can be vitamin C sodium salt (commercial reagent).
Further, when vitamin is vitamin C and vitamin C salt, the mass ratio of vitamin C and vitamin C salt is (3:7)~(7:3).
Specifically, Chinese cabbage freeze-dried powder is freeze-dried powder containing Chinese cabbage or Chinese cabbage freeze-dried powder.
The embodiment of the invention provides a kind of preparation method of Chinese cabbage freeze-dried powder enema, preparation method includes:
First dispersing agent is placed in the container of sterilization, then again by Chinese cabbage freeze-dried powder, vitamin, probiotics and paddy ammonia Amide is added in dispersing agent, fullys shake and is dispensed after mixing, obtains Chinese cabbage freeze-dried powder enema.
Specifically, the osmotic pressure of dispersing agent is 300~700mOsmol/L.
The Chinese cabbage freeze-dried powder enema is for preventing and treating intestines problem.
The preparation method that following is a brief introduction of Chinese cabbage freeze-dried powder, specifically includes:
Step 1: raw material selection: selecting the Chinese cabbage group on green blade face, and remove old root, insect gall on Chinese cabbage group Rotten and yellow leaf;
Step 2: cleaning: step 1 products therefrom is cleaned up, and be cut into size less than or equal to 4 centimetres ding shape or Strip removes metal object by magnetic separation;
Step 3: mashing: after step 2 products therefrom is passed through centrifuge centrifuge dripping, then passing through pulverizer and carry out for the first time It crushes, obtains powder slurry;
Step 4: quick-frozen: powder slurry being placed in freezer and is rapidly frozen, -35 DEG C of central temperature of powder slurry are made;
Step 5: dry: step 4 products therefrom is subjected to vacuum freeze drying, the temperature of vacuum freeze drying is -80~ 50 DEG C, the pressure of vacuum freeze drying is -100~-5Pa, and the time of vacuum freeze drying is 5~25h, obtains water content and is less than 3% desciccate;
Step 6: crushing: after desciccate is crushed by blender, then carrying out air-flow ultramicro grinding, obtain Chinese cabbage Freeze-dried powder;
Step 7: packaging: Chinese cabbage freeze-dried powder being passed through into normal temperature high voltage sterilization treatment, and is vacuum-packed with aluminium film.
Specifically, Chinese cabbage group (Brassica rapa, syn.campestris) includes containing Chinese cabbage and not balling Chinese cabbage, Chinese cabbage can be Chinese cabbage and cabbage, and Chinese cabbage can be common Chinese cabbage (Brassica campestris L.ssp.chinensis Makino)。
Embodiment one
A kind of raw material the embodiment of the invention provides Chinese cabbage freeze-dried powder enema, the Chinese cabbage freeze-dried powder enema includes: 50g Chinese cabbage freeze-dried powder, 10g vitamin C, 15g active Bifidobacterium, 3g glutamine, 7g sodium sulphate (alkali metal sulfates) and The sodium chloride injection (dispersing agent) that 1000g concentration is 0.9%.
Embodiment two
A kind of raw material the embodiment of the invention provides Chinese cabbage freeze-dried powder enema, the Chinese cabbage freeze-dried powder enema includes: 10g Chinese cabbage freeze-dried powder, 3g vitamin sodium salt, 0.5g active Bifidobacterium, 0.5g lactic acid bacteria, 0.1g glutamine, 1g magnesium sulfate The sodium chloride injection (dispersing agent) that (alkali earth metal sulfate) and 1000g concentration are 0.9%.
Embodiment three
A kind of raw material the embodiment of the invention provides Chinese cabbage freeze-dried powder enema, the Chinese cabbage freeze-dried powder enema includes: 100g Chinese cabbage freeze-dried powder, 10g vitamin C, 10g vitamin C sodium salt, 10g active Bifidobacterium, 10g lactic acid bacteria, 10g saccharomycete, 6g glutamine, 7g sodium sulphate (alkali metal sulfates), 8g magnesium sulfate (alkali earth metal sulfate) and 1000g concentration are 0.9% Sodium chloride injection (dispersing agent).
Technical solution provided in an embodiment of the present invention has the benefit that the paddy ammonia in the Chinese cabbage freeze-dried powder enema Amide has intestinal mucosa protective effect, and probiotics has the function of intestinal flora, Chinese cabbage freeze-dried powder effervescent tablet meals rich in Fiber, vitamin and mineral are eaten, a large amount of dietary fiber can promote the wriggling of stomach and intestine in Chinese cabbage freeze-dried powder, and it is residual to shorten food The time that slag retains in the enteric cavity of duodenum Yu large intestine junction, while can also help to dilute, drain toxin in enteron aisle, The synergistic effect of Chinese cabbage freeze-dried powder and vitamin can increase the tolerance of human body to the greatest extent, reduce hypertonic solution to body It influences, there is intestines problem health functions of preventing and treating.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.

Claims (10)

1. a kind of Chinese cabbage freeze-dried powder enema, which is characterized in that the raw material of the Chinese cabbage freeze-dried powder enema includes: Chinese cabbage freeze-drying Powder, vitamin, probiotics, glutamine and dispersing agent, the vitamin be at least one of vitamin C and vitamin C salt, The Chinese cabbage freeze-dried powder, the vitamin, the probiotics, the glutamine and the dispersing agent parts by weight be respectively 10 ~100 parts, 3~20 parts, 1~30 part, 0.1~6 part and 1000 parts.
2. Chinese cabbage freeze-dried powder enema according to claim 1, which is characterized in that the probiotics is Bifidobacterium, cream At least one of sour bacterium and saccharomycete.
3. Chinese cabbage freeze-dried powder enema according to claim 1, which is characterized in that when the vitamin is the vitamin C and when the vitamin C salt, the mass ratio of the vitamin C and the vitamin C salt is (3:7)~(7:3).
4. Chinese cabbage freeze-dried powder enema according to claim 1, which is characterized in that the dispersing agent is isotonic solution.
5. Chinese cabbage freeze-dried powder enema according to claim 4, which is characterized in that the isotonic solution is that inorganic salts are molten Liquid, the inorganic salts in the inorganic salt solution are alkali metal sulfates, alkali earth metal sulfate, sodium chloride, potassium chloride, bicarbonate At least one of sodium and the mixture of alkali metal sulfates and alkali earth metal sulfate.
6. Chinese cabbage freeze-dried powder enema according to claim 1, which is characterized in that the vitamin C salt is vitamin C Sodium.
7. a kind of preparation method of the Chinese cabbage freeze-dried powder enema as described in claim any one of 1-6, which is characterized in that the system Preparation Method include: by the raw material of the Chinese cabbage freeze-dried powder enema after mixing, obtain the Chinese cabbage freeze-dried powder enema.
8. preparation method according to claim 7, which is characterized in that the osmotic pressure of the dispersing agent be 300~ 700mOsmol/L。
9. preparation method according to claim 1, which is characterized in that the Chinese cabbage freeze-dried powder is freeze-dried powder containing Chinese cabbage Or Chinese cabbage freeze-dried powder.
10. a kind of application of Chinese cabbage freeze-dried powder enema as claimed in any one of claims 1 to 6, which is characterized in that described to answer With including: the Chinese cabbage freeze-dried powder enema for preventing and treating intestines problem.
CN201810909831.9A 2018-08-10 2018-08-10 A kind of Chinese cabbage freeze-dried powder enema and its preparation method and application Pending CN109223849A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111840393A (en) * 2020-08-26 2020-10-30 四川大学华西第二医院 Enema solution for children and preparation method thereof

Citations (6)

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Publication number Priority date Publication date Assignee Title
WO1989005659A1 (en) * 1987-12-24 1989-06-29 Borody Thomas J Orthostatic lavage solutions
CN1164396A (en) * 1996-09-19 1997-11-12 段卫平 Ecological enema liquid for curing functional constipation
CN101897721A (en) * 2002-10-25 2010-12-01 诺金公司 Colon cleansing compositions
CN102861108A (en) * 2012-09-07 2013-01-09 李宁 Pharmaceutical composition for treating constipation and application thereof
CN103007046A (en) * 2012-12-25 2013-04-03 浙江农林大学 Coloclysis liquid capable of preventing intestinal diseases, and application thereof
CN106722472A (en) * 2016-12-09 2017-05-31 王茹楠 A kind of preparation technology of the vegetables micro mist of the elderly

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989005659A1 (en) * 1987-12-24 1989-06-29 Borody Thomas J Orthostatic lavage solutions
CN1164396A (en) * 1996-09-19 1997-11-12 段卫平 Ecological enema liquid for curing functional constipation
CN101897721A (en) * 2002-10-25 2010-12-01 诺金公司 Colon cleansing compositions
CN102861108A (en) * 2012-09-07 2013-01-09 李宁 Pharmaceutical composition for treating constipation and application thereof
CN103007046A (en) * 2012-12-25 2013-04-03 浙江农林大学 Coloclysis liquid capable of preventing intestinal diseases, and application thereof
CN106722472A (en) * 2016-12-09 2017-05-31 王茹楠 A kind of preparation technology of the vegetables micro mist of the elderly

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111840393A (en) * 2020-08-26 2020-10-30 四川大学华西第二医院 Enema solution for children and preparation method thereof

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