JPH11302158A - Health food having intestinal function controlling action and produced by using enteric seam capsule - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a health food scarcely affected by gastric acid and water and effectively exhibiting the intestinal function controlling action by encapsulating a specific oil and fat and a specific valuable bacterium in a specific enteric seam capsule. SOLUTION: This health food is produced by encapsulating (A) an oil and fat having intestinal function controlling action, (B) a valuable bacterium having intestinal function controlling action and optionally (C) a water-absorbing substance (e.g. dried starch) in (D) an enteric seam capsule insoluble in gastric acid and soluble in the intestines. The component A is olive oil, palm oil, cottonseed oil, wheat embryo oil, fish oil, etc., the component B is Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium longum, etc., and the component D is e.g. a seam capsule made of gelatin and coated with a component suppressing the solubility in gastric acid (e.g. zein) or a seam capsule composed of gelatin containing sodium alginate.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a health food in which a component having an intestinal action is encapsulated in an enteric seam capsule.

[0002]

2. Description of the Related Art Conventionally, granules such as aloe, oligosaccharides, bifidobacteria, and lactic acid bacteria, tablets, capsules, and edible oils such as olive oil have been provided as health foods for the purpose of intestinal regulation.

[0003] Among these foods, useful bacteria such as bifidobacteria and lactic acid bacteria are known to grow in the intestinal tract from the small intestine to the large intestine, and to promote peristalsis of the intestinal tract by secretions during growth. However, the number of these useful bacteria is reduced by gastric acid. Therefore, there is a drawback that the effect of ordinary oral ingestion is greatly impaired, and the expected intestinal regulation cannot be obtained. On the other hand, if there is a useful bacterium having gastric acid resistance, it is considered that an effective intestinal regulating action will be brought about. From such a viewpoint, a search for useful gastric acid-resistant bacteria has been carried out, but the fact is that useful bacteria having complete resistance and a remarkable effect have not yet been found.

[0004] Further, it has been recognized that these useful bacteria have a property of decreasing the number of bacteria in the presence of water. Useful bacteria are provided as products in the form of granules, tablets, capsules, etc., but in many cases these products absorb water during storage, resulting in a decrease in the number of useful bacteria and a large intestinal effect. Is something that cannot be expected.

In addition, fats and oils having an intestinal action, such as olive oil, stimulate the peristaltic movement of the intestinal tract in the intestinal tract from the small intestine to the large intestine, and further have a function as a lubricating oil for facilitating excretion of feces in the large intestine. It has been known.

However, 90% or more of these fats and oils are absorbed into the body, and when ingesting them for the purpose of intestinal regulation, it is necessary to take a considerable amount of fats and oils. Ingesting large amounts of fats and oils solely for the purpose of intestinal regulation is not desirable from a health and nutritional point of view. There is a need for a method of ingesting a necessary amount of the substance to produce an intestinal effect.

[0007]

DISCLOSURE OF THE INVENTION The present invention is directed to a means for causing useful bacteria to perform an effective intestinal action without being significantly affected by stomach acid and water, and an effective intestinal action by ingesting a small amount of edible oils and fats. It is intended to provide a means for obtaining an effect. The present inventors have intensively studied means for encapsulating useful bacteria or useful oils and fats, and particularly focused on enteric seam capsules,
The present invention has been completed.

[0008]

The gist of the present invention is to provide an enteric seam capsule which does not dissolve in the stomach acid but dissolves in the intestinal tract, and encloses fats and oils having an intestinal action and useful bacteria having an intestinal action. It is a health food characterized by encapsulating oils and fats having intestinal action, useful bacteria having intestinal action, and a water-absorbing substance in an enteric seam capsule that dissolves in the intestinal tract without dissolving in gastric acid. It is a health food.

As the enteric seam capsule, a seam capsule made of gelatin coated with a component that inhibits solubility in gastric acid, or a seam capsule made of gelatin containing sodium alginate can be used. At this time, zein and sodium alginate may be used as the material to be coated on the seam capsule.

[0010] Also, oils and fats having an intestinal action include olive oil, palm oil, cottonseed oil, wheat germ oil, soybean oil,
Palm oil, corn oil, at least one selected from the group consisting of safflower oil and fish oil can be used, and as a useful bacterium having an intestinal action, Lactobacillus acidophi
lus, Lactobacillus casei, Lactobacillus bulgaricu
At least one selected from the group consisting of s, Lactobacillus lactis, Bifidobacterium brave and Bifidobacterium longum can be used, and dried starch can be used as a water-absorbing substance.

If edible oils and fats or useful bacteria having an intestinal action are sealed in a container which does not dissolve in the stomach but dissolves only in the intestine, the oils and fats can be consumed in a small amount,
For useful bacteria, the number of bacteria in the stomach does not decrease,
Intestinal rectification can be effectively performed in the intestine. The present invention has been made based on this principle. In other words, in an enteric seam capsule that dissolves in the intestine without dissolving in stomach acid,
By enclosing edible oils and fats and useful bacteria having an intestinal action, the intestine action is effectively performed.

When useful bacteria are used, it is desirable to ingest 500,000 to 10 billion bacteria per day. However, most useful bacteria are generally killed by stomach acid, although there are differences depending on the strain and the like. Since useful bacteria grow in the intestinal tract, it is considered effective if some of the number of ingested bacteria survives.However, in an intestinal environment where there is a constant competition with other bacteria, intestinal tracts should be used as much as possible. It is required to increase the number of useful bacteria that reach the plant. The use of enteric seam capsules allows them to work effectively without reducing the number of useful bacteria.

An enteric seam capsule is filled and encapsulated by combining an edible oil / fat having an intestinal action and useful bacteria. Furthermore, in addition to the edible oil and fat having an intestinal action and useful bacteria, a water-absorbing substance is combined and filled and sealed.

The enteric seam capsule can be obtained by coating the surface of a normal gelatin seam capsule coating with a component that inhibits solubility in stomach acid, or by manufacturing the seam capsule coating itself with a substance that is difficult to dissolve in stomach acid. . Zein or sodium alginate can be used as a substance to be coated on the surface of the seam capsule film. Specifically, a gastric acid-resistant seam capsule can be obtained by applying an aqueous solution of zein, sodium alginate, or the like to the surface of a seam capsule obtained from gelatin. In coating, zein alone or sodium alginate alone may be used, or both may be used in combination. A seam capsule obtained from gelatin containing sodium alginate can also be used as a gastric acid-resistant seam capsule.

Useful bacteria having an intestinal action include lactic acid bacteria (Lactobacillus acidophilus, Lactobacillus case).
i, Lactobacillus bulgaricus, Lactobacillus lactis
Etc.), Bifidobacterium (Bifidobacterium brave, Bifido
bacterium longum).

Olive oil, palm oil, cottonseed oil, wheat germ oil, soybean oil, coconut oil, corn oil, safflower oil, fish oil and the like can be used as the fat and oil having an intestinal action. These fats and oils are partially digested by stomach acid in the stomach, and further neutralized by enzymes such as lipase after neutralization,
Over 90% is absorbed in the small intestine. For this reason, it is considered that the lubricating effect on stool in the large intestine, which is the main intestinal regulating effect, is due to a small amount of unabsorbed fat and oil.

On the other hand, the use of the enteric seam cabcell of the present invention allows the edible oil and fat to pass through the stomach without being digested and reach the intestine, so that a large intestinal effect can be expected with a small amount of ingestion.

By mixing the water-absorbing substance into the fat or oil to be filled in the capsule, the influence of the water content in the capsule on the number of useful bacteria can be further suppressed. As a result, the effect of water on useful bacteria can be suppressed. As the water-absorbing substance, specifically, dried starch can be used.

The appropriate amounts of useful bacteria and useful fats and oils are generally as follows. In an enteric seam capsule, 100 mg of useful bacteria such as bifidobacteria and lactic acid bacteria, 200 mg of oil and fat such as olive oil, and 50 moisture absorbing materials such as dried starch are added.
It is desirable to use about mg. The present invention is not necessarily limited to this quantitative ratio.

[0020]

Next, the effects of the present invention will be described based on embodiments.

[0021]

Example 1 A test was conducted to confirm the effect of the present invention on intestinal action. 1. Test Method Various subjects were ingested once a day at an arbitrary time for nine volunteers who participated as volunteers, and the effects were examined for the number of defecations, stool volume, and stool properties. At this time, the number of defecations is shown not by the number of days but by the number of defecations per week, because of individual differences. For the amount of stool,
It was the amount per serving. In terms of the stool properties, the color tone and lightness (black brown became bright yellow) were improved, and the hardness was softened (hard but soft) was improved. In addition, he showed comprehensive findings.

2. Samples Five types of samples were prepared. A brief description of each sample and its contents are shown below. (1) Bifidobacterium and olive oil encapsulated in an enteric seam capsule Bifidobacterium count 10 billion Olive oil amount 0.6 ml Enteric processing Yes (2) Bifidobacterium granule Bifidobacterium count 10 billion Oil amount None Enteric No processing (3) Bifidobacterium tablets Bifidobacterium count 10 billion Oil amount None Enteric processing None (4) Olive oil Bifidobacterium count None Olive oil amount 10 ml Enteric processing None (5) Olive oil in enteric seam capsule Included Bifidobacterium count None Olive oil 10ml Enteric coating Yes

3. Test results Table 1 shows the test results for the sample (1). The meanings of the evaluation points in this table are as shown in Table 2. The contents of Table 2 are the same for Tables 3 to 6. Table 3 shows the test results for Sample (2), Table 4 shows the test results for Sample (3), Table 5 shows the test results for Sample (4), and Table 6 shows the test results for Sample (5). It was shown to.

[0024]

[Table 1]

[0025]

[Table 2]

[0026]

[Table 3]

[0027]

[Table 4]

[0028]

[Table 5]

[0029]

[Table 6]

In the case of Bifidobacterium alone, when the ingested form is granules (specimen 2), the intestinal regulation effect is slightly recognized, but when the tablet (specimen 3) is used, the intestinal regulation effect is not remarkably recognized. In addition, in the case of olive oil alone, even if a large amount of olive oil is ingested, almost no intestinal regulation effect is recognized regardless of whether enteric seam capsules are used (sample 5) or not (sample 4). On the other hand, in the specimen 1 according to the present invention, in which the useful bacterium Bifidobacterium and a small amount of olive oil are combined and the enteric seam capsule is encapsulated, a remarkable intestinal regulation effect is observed.

[0031]

Example 2 In order to suppress the decrease in the number of useful bacteria, a test was conducted in which a water absorbent was used. Olive oil 2
Parts by weight, 1 part by weight of bifidobacteria and 0.5 parts of dried starch
The parts by weight were mixed and allowed to stand at room temperature, and the change over time in the viable cell count was observed. As a control, a system containing no dried starch, that is, a system consisting of 1 part by weight of bifidobacteria and 2 parts by weight of olive oil was simultaneously tested. The test results are
As shown in Table 7, it can be seen that the system containing dried starch significantly reduces the reduction of viable bacteria as compared to the system not containing dried starch. This is because when using useful bacteria, oils and fats as health food, dry starch is added,
This indicates that the decrease in the number of viable bacteria is suppressed and the intestinal control effect is improved.

[0032]

[Table 7]

[0033]

EFFECT OF THE INVENTION Food fats and oils having intestinal action, useful bacteria,
Alternatively, by ingesting a water-absorbing substance encapsulated in a gastric acid-resistant enteric-soluble seam capsule, a remarkable intestinal regulation effect is exhibited with a small amount of intake. This effect is remarkable compared with conventionally known granules, tablets and capsules of bifidobacteria and lactic acid bacteria.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 35/78 A61K 35/78 K C J U

Claims (8)

[Claims] 1. A health food comprising an enteric seam capsule which is soluble in the intestinal tract without being dissolved by gastric acid, and in which an oil and fat having an intestinal action and useful bacteria having an intestinal action are encapsulated. 2. An enteric seam capsule which does not dissolve in gastric acid but dissolves in the intestinal tract, and encloses fats and oils having an intestinal action, useful bacteria having an intestinal action, and a water-absorbing substance. Food. 3. The enteric seam capsule according to claim 1, wherein a seam capsule made of gelatin is coated with a component that inhibits solubility in gastric acid.
Or the health food according to claim 2. 4. The health food according to claim 1, wherein the enteric seam capsule is a seam capsule made of gelatin containing sodium alginate. 5. The fat or oil having an intestinal action, comprising: olive oil, palm oil, cottonseed oil, wheat germ oil, soybean oil, coconut oil,
The health food according to claim 1 or 2, wherein the health food is at least one selected from the group consisting of corn oil, safflower oil, and fish oil. 6. A useful bacterium having an intestinal regulating action is Lactobacil
lus acidophilus, Lactobacilluscasei, Lactobacillu
s bulgaricus, Lactobacillus lactis, Bifidobacteri
The health food according to claim 1 or 2, wherein the health food is at least one selected from the group consisting of umbrave and Bifidobacterium longum. 7. The health food according to claim 2, wherein the moisture-absorbing substance is dried starch. 8. The enteric seam capsule according to claim 3, wherein the component for suppressing the solubility in gastric acid coated on the seam capsule is zein or / and sodium alginate.