JP2008109910A - Enzyme-compounded granule acting in intestine, and enzyme-compounded food using the enzyme-compounded granule - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To make an enzyme and an enteric substance to arrive at an intestine without being exposed to a gastric juice. <P>SOLUTION: An oil liquid 2 containing CoQ<SB>10</SB>of enteric substance is encapsulated with a gelatin coating film 3 to form a seamless nucleus 1, and an enzyme-containing coating film 4 is disposed on the surface of the seamless nucleus 1 to form an enzyme-compounded granule 5. The enzyme-compounded granules 5 are charged and sealed in a hard capsule 6, and the whole surface of the capsule is coated with zein 7 to form an enzyme-compounded food 8. When the enzyme-compounded food 8 is drunk, the enzyme-compounded food 8 arrives at the intestine through a stomach without being dissolved in a gastric juice due to the existence of the coating layer of the zein 7. The coating layer of the zein 7, and the hard capsule 6 are sequentially collapsed in the intestine, and the enzyme compounded in the enzyme-containing coating films 4 of the enzyme-compounded granules 5 are released in the intestine. The gelatin coating films 3 of the seamless nuclei 1 exposed by the collapse of the coating films 4 are collapsed to release the oil liquid 2 containing the CoQ<SB>10</SB>in the intestine. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention uses an enzyme-containing granule capable of releasing a necessary fat-soluble active ingredient into the intestine while allowing enzymes derived from animals, plants, microorganisms, etc. to function in the intestine, and the enzyme-containing granule. It is related to the enzyme-mixed food.

  The energy that supports human physical and mental activities is generated by digesting food with a complex of several enzymes (complex enzyme) and metabolizing it in the body. Therefore, various digestive enzymes and metabolic enzymes play a very important role, but among these enzymes, if the food you eat is not digested well due to the action of the digestive enzymes, the nutrients contained in them Cannot be absorbed into the body and therefore cannot be utilized for metabolism in the body.

  By the way, although there are individual differences, in general, when the amount of the whole enzyme in the body gradually decreases with aging and aging, the emphasis is placed on metabolic enzymes involved in metabolism in the body, so even digestive enzymes Digestion and absorption tend to decline due to the inability to respond, which may make it difficult to break down proteins, fats and sugars. For example, with the age of years, the preferred ingredients change from meat-centric to fish and vegetable-centric because the amount of enzymes used to digest meat decreases with age. This is thought to be due to this. Therefore, it is conceivable to supplement the enzymes in the body by taking various enzymes as food from the outside.

  By the way, as a conventionally proposed enzyme food, for example, wheat germ, soybean germ, rice germ, brown rice germ steamed and fermented with koji mold, yeast, yeast, etc., powder, granule, tablet There is one that can be taken orally in a form (for example, see Patent Document 1).

  Note that tablets, hard capsules, soft capsules, and granules are widely used as shapes (dosage forms) of foods having functionality such as nutritional supplements.

  In addition, when a food product is formed into granules, in order to produce granules of uniform particle size, the desired components on the surface are formed with sugar spherical particles having a high sphericity and a sharp particle size distribution as the core. Conventionally, a technique for coating the film is known (see, for example, Patent Document 2).

  Furthermore, a seamless capsule formed by encapsulating a required oil liquid in a capsule film such as gelatin by a dropping method using a coaxial double nozzle is conventionally known (see, for example, Patent Document 3).

  In addition, as a method for reaching the intestine without bringing oral ingestion into contact with gastric juice, hard capsules containing oral ingestion are extracted from corn, purified zein that is difficult to dissolve in gastrointestinal and has enteric properties ( Enteric-coated foods that are enteric-coated with zen or zein have also been proposed (see, for example, Patent Document 4).

JP 2001-120203 A Japanese Patent Laid-Open No. 5-229961 JP-A-7-196478 JP 2001-309756 A

  However, the enzyme foods described in Patent Document 1 are proteins, fats, and sugars contained in wheat germ, soybean germ, rice germ, brown rice germ, which cannot be degraded well in the body, in advance with koji mold, yeast, yeast, etc. Fermentation makes it easy to digest and absorb, and then it can only be taken orally as powders, granules, or tablets, and supplements from the outside digestive enzymes that tend to be deficient in the body, especially in the intestines with age. It is not something that can be done.

  Therefore, the actual condition is that no enzyme-enriched food that can supplement the digestive enzyme deficient in the intestine from the outside has been proposed.

  By the way, among various dosage forms widely used for functional foods such as nutritional supplements, tablets are easy to swallow and the desired ingredients can be gathered compactly. Although it is possible to mask off-flavor and off-flavor components, an excipient for uniformly mixing the desired components and a binder for compaction are required. There is a problem that the amount of the product becomes large and the mixing ratio of the main component becomes low. In addition, normally, tablets can only be blended with ingredients that are easily powdered and solidified, such as water-soluble substances, and fat-soluble substances can be blended if they can be powdered once. Although it is possible, it is difficult to mix in a liquid state.

Since soft capsules can be encapsulated in a state in which a fat-soluble substance is dissolved in oil, the capsule contents have high stability against air oxidation, and in the manufacturing process, heating and heating at 40 ° C. or higher. Since there is no process or pressurization process and the content components are not in contact with air, there is an advantage that there are few quality degradation factors and human processing factors, and there is little variation in size and content of content components. It is possible to enhance the uniformity of the solution, mask off taste and odor components, and further, the contents are oils and fats, and the water activity of the film is low, so that it is difficult to be contaminated by microorganisms and easy to swallow. is there. However, the size is about 200 mg per grain at least, and the capsule coating is about 30% by weight, so the remaining 70% is an oily component (oil solution) to be included. In addition to the fat-soluble active ingredient, more than the required amount of edible oil is blended. That is, for example, even when coenzyme Q ₁₀ (CoQ ₁₀ ) is desired to be added at about 30 mg per capsule, it is necessary to add about 110 mg of edible oil in addition to that, so excessive oil must be consumed. We are concerned about the problem of not becoming. Moreover, in order to mix | blend a water-soluble substance, since it is necessary to melt | dissolve in fats and oils using surfactant, it is difficult to process and the compounding quantity will also be restrict | limited. Furthermore, it is necessary to drink 5 to 6 soft capsules in order to bring the intake amount of the active ingredient, which is a water-soluble substance whose amount is limited to a small amount, to the desired daily intake amount. Yes, in such a case, the amount of oil intake is further increased. Moreover, conventionally, since capsule capsules of soft capsules are usually gelatin films, there is a concern that soft capsules may easily adhere to each other when stored for a long time.

  Hard capsules can mask inclusions, so that even pigments and dyeable materials can keep the mouth, teeth, or containers clean, and in the manufacturing process, heating, heating, humidification, Since there is no drying or pressing process, there is an advantage that the cause of quality deterioration is extremely small compared to tablets, and it is possible to reduce the amount of additives and increase the main component content. However, as in the case of the above-mentioned tablets, it is limited to ingredients that can be easily solidified such as powdered or granulated, such as water-soluble substances. It is necessary to solidify such as to form, and it is difficult to mix in a liquid state. Moreover, since the hard capsule itself dissolves in the stomach, the inclusion is released in the stomach.

  Therefore, as shown in Patent Document 4 above, in order to allow the inclusion of the hard capsule to reach the intestine without being in contact with the gastric juice, the hard capsule is hardly gastrolytic and enteric. However, even in this case, it is not possible to improve the point that it is difficult to blend a fat-soluble substance.

  Granular foods produced by coating the desired ingredients on the surface of sugar spherical particles with a high sphericity and a uniform particle size distribution as shown in Patent Document 2 are easier to drink than powder and absorb quickly. In addition to being able to reduce the amount of additives such as excipients and binders, and to be able to make granules with high sphericity, it is said that the appearance can be improved However, since a sugar core is required for the production of granules, there is a concern that sugar intake may increase. Moreover, it is difficult to mix a fat-soluble substance with the granule.

  Incidentally, since the seamless capsule shown in Patent Document 3 is water-soluble, its inclusion is limited to an oily liquid. Therefore, as with the soft capsule described above, a fat-soluble substance can be blended, but a water-soluble substance is blended. Have difficulty. In addition, gelatin-free seamless capsules dissolve quickly when they reach the stomach, so that the inclusions are released in the stomach, making it difficult to reach the intestine without touching the gastric juice. .

  In addition, the above Patent Documents 2, 3, and 4 have no idea of supplementing the digestive enzyme deficient in the intestine from outside.

  In view of this, the present invention provides an enzyme such as an animal-derived, plant-derived, or microorganism-derived enzyme in the intestine so that an enzyme such as a digestive enzyme deficient in the intestine can reach the intestine from the outside to be supplemented. The enzyme-containing granule that allows the desired fat-soluble active ingredient to be released into the intestine at the same time, as well as the enzyme using the enzyme-containing granule It is intended to provide a combination food.

  In order to solve the above-mentioned problem, the present invention, corresponding to claim 1, comprises a fat-soluble active ingredient-containing oil solution obtained by dissolving a fat-soluble active ingredient in edible oil, and encapsulating it in a gelatin coating to form a seamless core. Formed into an enzyme-containing granule that functions in the intestine having a structure in which the surface of the seamless core is covered with an enzyme-containing coating film containing a required enzyme.

  According to claim 2, a fat-soluble active ingredient-containing oil solution obtained by dissolving a fat-soluble active ingredient in edible oil is encapsulated in a gelatin coating to form a seamless core, and the surface of the seamless core is An enzyme-containing granule is formed by covering with an enzyme-containing coating film containing the required enzyme, and the enzyme-containing granule is encapsulated in a hard capsule, and the surface of the hard capsule is coated over the entire surface with a gastric insoluble and enteric substance. It is set as the enzyme mixing | blending foodstuff which has the structure formed.

  Furthermore, the seamless core of the enzyme-blended granules in the above-mentioned enzyme-blended food composition is made into a seamless capsule using a fat-soluble active ingredient-containing oil solution and a gelatin solution for forming a gelatin coating as a raw material, and on the surface of the seamless nucleus The powder raw material containing the required enzyme and excipient is laminated with the required thickness via the required coating solution to form an enzyme-containing coating film to form an enzyme-containing granule.

  Furthermore, the enzyme-containing coating film in each component of the enzyme-containing food is individually provided with microorganism-derived, plant-derived, and animal-derived enzymes, and pigments of different colors for the microorganism-derived, plant-derived, and animal-derived enzymes. Three types of enzyme-mixed granules formed by mixing are formed, and the three types of enzyme-containing granules are mixed one by one or a plurality of types and sealed in a hard capsule.

According to the present invention, the following excellent effects are exhibited.
(1) A fat-soluble active ingredient-containing oil solution obtained by dissolving a fat-soluble active ingredient in edible oil is encapsulated in a gelatin coating to form a seamless nucleus, and the surface of the seamless nucleus contains an enzyme containing a required enzyme. Since it is an enzyme-containing granule that functions in the intestine and is covered with a coating film, when the enzyme-containing granule reaches the intestine and disintegrates the enzyme-containing coating film in the intestine, the enzyme-containing coating film The contained enzyme can be released into the intestine, and the function of the enzyme can be exerted in the intestine. At the same time, the gelatin coating of the seamless core that is exposed as the enzyme-containing coating film collapses dissolves in the intestine, so that the fat-soluble effective contained in the oil solution containing the fat-soluble active ingredient contained in the gelatin film. The components can also be released into the intestine together with the enzyme.
(2) Therefore, an enzyme that is inherently water-soluble can be blended in a dry state, and a fat-soluble active ingredient can be easily blended together into a granule.
(3) A fat-soluble active ingredient-containing oil solution obtained by dissolving a fat-soluble active ingredient in edible oil is encapsulated in a gelatin coating to form a seamless nucleus, and the surface of the seamless nucleus contains an enzyme containing a required enzyme. Enzyme-containing granule is formed by covering with a coating film, the enzyme-containing granule is enclosed in a hard capsule, and the surface of the hard capsule is coated with a gastric insoluble and enteric substance over the entire surface. Because it is a blended food, the presence of the above-mentioned poorly soluble and enteric substance in the stomach can prevent the hard capsule from collapsing in the stomach, and the enzyme-containing granule enclosed in the hard capsule can be prevented from coming into contact with the gastric juice. It is possible to reliably reach the intestines in a state. Thereafter, when the enzyme-containing food reaches the intestine, the hard capsule can be disintegrated by rapidly dissolving the gastric insoluble and enteric substance coating and exposing the hard capsule. The enzyme-containing granule encapsulated therein can be released into the intestine, and the enzyme-containing coating film of the enzyme-containing granule can be disrupted. As a result, the enzyme contained in the enzyme-containing coating film is allowed to reach the intestine in a state where the possibility of being deactivated by contact with gastric juice is prevented, and the function of the enzyme in the intestine An oil containing a fat-soluble active ingredient contained in the gelatin coating as a result of the collapse of the gelatin coating of the seamless core that is exposed as the enzyme-containing coating coating is collapsed. The fat-soluble active ingredient contained in the liquid can also be released into the intestine while preventing contact with the gastric juice.
(4) Therefore, the enzyme-containing food can be a food having a function of allowing both a required enzyme and a fat-soluble active ingredient to reach the intestine.
(5) The seamless core of the enzyme-blended granule is made into a seamless capsule using an oil solution containing a fat-soluble active ingredient and a gelatin solution for forming a gelatin coating, and the surface of the seamless core is coated with the required enzyme. The above-mentioned seamless core is made into a spherical shape and particle size by laminating the powder raw material containing the formant with the required thickness through the required coating liquid to form an enzyme-containing coating film to form an enzyme-containing granule. In addition, the enzyme-containing granule formed with the seamless core as a central core can be made into a spherical shape and a uniform particle size. Thereby, it is possible to easily control the filling amount when performing the filling operation for encapsulating the enzyme-containing granule in a hard capsule.
(6) Three types of enzymes obtained by individually blending an enzyme-containing coating film with microorganism-derived, plant-derived, and animal-derived enzymes, and pigments having different colors for the microorganism-derived, plant-derived, and animal-derived enzymes. By forming a blended granule and configuring the three kinds of enzyme blended granule to be sealed in a hard capsule by mixing one kind or plural kinds, it is difficult to dissolve in the stomach and enteric substances on the entire surface. From the color of the enzyme-containing granule observed through the hard capsule coated, whether the enzyme contained in one capsule of the enzyme-containing food of the present invention is a microorganism-derived, plant-derived or animal-derived enzyme, Or the appearance appeal effect that it becomes possible to judge easily whether it contains 2 or 3 types of enzymes derived from microorganisms, plants and animals is expected.

  The best mode for carrying out the present invention will be described below with reference to the drawings.

  1 (a) and 1 (b) show an embodiment of the enzyme-containing food of the present invention, which has the following configuration.

That is, as a fat-soluble active ingredient, for example, CoQ _10- containing oil liquid 2 as a fat-soluble active ingredient-containing oil liquid prepared by dissolving CoQ ₁₀ in a required concentration in a required edible oil has a film thickness of 0.2 to A seamless capsule-shaped seamless nucleus 1 having a diameter of 0.7 to 1.2 mm is formed by being encapsulated in a 0.4 mm gelatin coating 3, and the surface of the seamless nucleus 1 is covered with an enzyme-containing coating coating 4 containing an enzyme. Thus, the enzyme-containing granule 5 is produced. Further, the enzyme-containing granule 5 is encapsulated in a hard capsule 6 made of gelatin in a required amount, and the surface of the hard capsule 6 is coated over the entire surface with zein 7 as an enteric substance that is hardly soluble in the stomach. The enzyme-containing food 8

  Hereinafter, the structure of the said enzyme compound food 8 is explained in full detail along a manufacture procedure.

In the case of producing the enzyme-mixed food 8, first, CoQ ₁₀ , which is known as a fat-soluble active ingredient, decreases with aging and is known to have an effect of activating cell activity by supplementing the deficiency. As an edible oil, for example, a CoQ _10- containing oil liquid 2 is produced by mixing and dissolving in medium chain fatty acid triglyceride (MCT). At this time, the concentration of the CoQ ₁₀ in the CoQ _10- containing oil liquid 2 is included in, for example, all the enzyme-containing granules 5 sealed per capsule of the enzyme-containing food 8 to be finally produced. the amount of _{CoQ 10} contained in the total amount of CoQ ₁₀ containing liquid 2 in advance so as to adjust to approximately 30 mg.

Next, using the CoQ _10- containing oil solution 2 and the gelatin solution for forming the gelatin coating 3, the seamless core 1 is formed by a dropping method using a coaxial double nozzle, which is widely known as one of pharmaceutical technologies. Form. Specifically, the CoQ _10- containing oil solution 2 is supplied from the inner (center side) flow path of the concentric double nozzle, and the gelatin solution is supplied from the outer (outer peripheral side) flow path of the double nozzle. Are simultaneously discharged, the CoQ _10- containing oil solution 2 is encapsulated in the gelatin solution by utilizing surface tension (interfacial tension), and then the gelatin solution is solidified to obtain the gelatin having the predetermined film thickness. A coating 3 is formed. As a result, the spherical seamless core 1 having the above-mentioned predetermined diameter having a configuration in which the CoQ _10- containing oil solution 2 in the center is coated with the uniform gelatin coating 3 is manufactured.

  Next, the seamless core 1 is agitated so as to make a planetary motion using, for example, a centrifugal force by rotating with a rotor (not shown) and slit air, while quantitatively spraying a required coating liquid (binding liquid), A powder raw material containing a required enzyme, an excipient, and other required additives to be blended is quantitatively dispersed, whereby the powder raw material is applied to the surface of the seamless core 1 with a required thickness. To form an enzyme-containing coating film 4. As a result, enzyme-containing granules 5 having a spherical shape and a uniform particle size are produced by coating the surface of the spherical seamless core 1 with a uniform enzyme-containing coating film 4 as shown in FIG.

  As the enzyme to be blended when forming the enzyme-containing coating film 4, various enzymes derived from microorganisms, plants, and animals may be appropriately selected and used. Specifically, examples of microorganism-derived enzymes include cellulases derived from bacteria that can be expected to have the effect of reducing cellulose in the intestine to reduce abdominal bloating and reducing gas, and include various enzymes derived from lactic acid bacteria. In order to efficiently incorporate nutrients into the body, lactic acid bacteria metabolites and the like that can be expected to improve the intestinal environment can be used. Examples of plant-derived enzymes include papain, which is a proteolytic enzyme and can be expected to aid digestion, and actinidin, a proteolytic enzyme, and kiwi juice powder containing natural vitamin C and vitamin E. Etc. can be used. Moreover, as an enzyme derived from an animal, for example, egg white lysozyme which can be expected to have a lytic action of bacteria, placenta extract powder containing amino acids and proteins in addition to enzymes can be used.

Moreover, as an additive mix | blended when forming the said enzyme-containing coating film 4, the enzyme mixing | blending granule 5 enclosed by the hard capsule 6 at a post process is aimed at improving the appeal effect on the external appearance with respect to a consumer, for example. You may make it mix | blend the additive containing the pigment | dye for coloring previously. As an additive containing this type of pigment, if red coloring is intended, for example, in addition to the red pigment, red yeast rice containing mevinolin that can be expected to lower cholesterol is used. That's fine. For the purpose of green coloring, for example, a chlorophyll that is a green pigment and can be expected to compensate for the lack of iron may be used. For the purpose of yellowing, for example, vitamin B ₂ which is a yellow substance and can be expected to promote the regeneration and generation of cells may be used.

  Furthermore, you may make it color the said enzyme mixing granule 5 according to the kind of enzyme currently mix | blended. Specifically, for example, the enzyme-containing coating film 4 containing the microorganism-derived enzyme as described above is blended with red yeast so that the enzyme-containing granule 5 containing the microorganism-derived enzyme is colored red. In addition, by adding chlorophyll to the enzyme-containing coating film 4 containing a plant-derived enzyme, the enzyme-containing granule 5 containing the plant-derived enzyme is colored green, and the animal-derived enzyme is If the enzyme-containing granule 5 containing the animal-derived enzyme is colored yellow by blending vitamin B6 in the enzyme-containing coating film 4 to be contained, the enzyme contained in each enzyme-containing granule 5 However, it is also possible to expect an appealing effect on the appearance that it can be easily distinguished from the color of the granule whether it is derived from microorganisms, plants, or animals.

  Thereafter, the produced enzyme-containing granule 5 is filled into the hard capsule 6 in a required amount and sealed. During the filling and enclosing operation, the enzyme-containing granule 5 has a spherical shape and a uniform particle size, so that the filling amount into the hard capsule 6 can be controlled accurately and easily.

  Furthermore, when filling and encapsulating the enzyme-containing granule 5 in the hard capsule 6, for example, the above-mentioned microorganism-derived, plant-derived, and animal-derived enzymes are individually included and red, green, Two or three kinds of enzyme-containing granules 5 color-coded in yellow may be mixed and filled into the hard capsule 6 so that the enzyme-containing granules 5 are spherical and have a particle size. Therefore, two or three types of enzyme-containing granules 5 that individually contain the above-mentioned different types of enzymes are precisely controlled so that the mixing amount becomes a predetermined mixing ratio, for example, equal amounts. Thus, the hard capsule 6 can be filled and sealed.

  Thereafter, the zein 7 is applied to the entire surface of the hard capsule 6 encapsulating the enzyme-containing granule 5 with the required thickness, specifically, while the enzyme-containing food 8 of the present invention passes through the stomach. Coating is performed so that the coating layer of zein 7 does not dissolve even when exposed to gastric juice, and has the required thickness dimension so that the coating layer of zein 7 dissolves quickly when the enzyme-mixed food 8 reaches the intestine. Thus, the enzyme-containing food 8 of the present invention is formed.

  When the enzyme-containing food 8 of the present invention having the above structure is swallowed, the enzyme-containing food 8 is prevented from disintegrating hard capsules in the stomach due to the presence of the coating layer of zein 7 formed in the outermost layer. Thus, the enzyme-containing granules encapsulated in the hard capsule are passed through the stomach in a state where contact with the gastric juice is prevented. Thereafter, when reaching the intestine, the hard capsule 6 is exposed because the coating layer of the zein 7 is rapidly dissolved, and then the hard capsule 6 is disintegrated and the internal enzyme-containing granules 5 are released into the intestine. Furthermore, by disintegrating the enzyme-containing coating film 4 of the enzyme-containing granule 5, enzymes derived from microorganisms, plants, animals, and the like mixed in the enzyme-containing coating film 4 are released into the intestine, The function of the enzyme is exhibited in the intestine, and absorption of water-soluble substances such as enzymes and additives mixed in the enzyme-containing coating film 4 in the intestine is achieved.

Further, when the seamless nucleus 1 is exposed as the enzyme-containing coating film 4 is collapsed, the outer gelatin film 3 in the seamless nucleus 1 is collapsed, so that the CoQ ₁₀ contained in the gelatin film 3 is contained. The oil liquid 2 is released into the intestine, and absorption of CoQ ₁₀ which is a fat-soluble active ingredient blended in the oil liquid 2 into the intestine is achieved.

Thus, according to the enzyme-containing food 8 of the present invention, the compounded enzyme can reach the intestine without being decomposed by gastric juice, and the function of the enzyme can be exhibited in the intestine. It is possible to supplement enzymes such as digestive enzymes that are deficient in the intestines. Furthermore, the enzyme-mixed food 8 can be blended with the enzyme that is inherently water-soluble in a dry state, and can also be blended with CoQ ₁₀ that is a fat-soluble substance together easily. CoQ ₁₀ as a component can also be released by reaching the intestine without being exposed to gastric juice, and can be used for absorption in the intestine.

The enzyme-containing granule 5 having a high sphericity and a uniform particle size has a seamless capsule-like seamless core 1 in which a CoQ _10- containing oil solution 2 is enclosed in a gelatin coating 3 as a central core, and the surroundings of the enzyme-containing granule 5. Since the coating film 4 is formed by coating, the sugar spherical particles as conventionally used in the technique described in Patent Document 2 to produce granules having a high sphericity are cores. Therefore, it is possible to reduce sugar intake.

Furthermore, since the oil for blending CoQ ₁₀ which is the above fat-soluble substance is only CoQ _10- containing oil liquid 2 included in the gelatin coating 3 in each seamless core 1, conventionally, a fat-soluble substance is blended. The amount of oil used can be reduced and the amount of oil intake can be reduced as compared with the soft capsule used as a dosage form.

  The enzyme-containing granule 5 is produced by a dropping method, with the seamless capsule-shaped seamless core 1 having a high sphericity and a uniform particle size as the central core, and the periphery thereof is coated with the enzyme-containing coating film 4. As such, it can be a granule having a high sphericity and a uniform particle size. Therefore, the filling amount when filling the hard capsule 6 can be controlled accurately and easily, and two types of enzyme-containing granules 5 each containing each of the enzymes derived from microorganisms, plants and animals are separately provided. Or, even when three types of the above-mentioned hard capsules 6 are mixed and filled, the two or three types of enzyme-containing granules 5 individually containing the different types of enzymes are mixed at a predetermined mixing ratio. The amount can be accurately controlled.

  Furthermore, the enzyme-containing granule 5 that is observed through the hard capsule 6 if the enzyme-containing granule 5 that individually contains the microorganism-derived, plant-derived, and animal-derived enzymes is color-coded into red, green, and yellow. From the color of 5, the consumer can easily determine whether the enzyme blended in the enzyme blended food 8 of the present invention is derived from microorganisms, plants, or animals.

  The present invention is not limited only to the above embodiment, and the enzyme to be blended in the enzyme-containing coating film 4 is an enzyme that can be blended in food and desired to reach the intestines. Any enzyme other than those exemplified in the above embodiment may be used.

  The color in the case of coloring the enzyme-containing granule may be set to any color other than those exemplified in the above embodiment, and as an additive containing a pigment for use in the coloring, it can be added to food. As long as there is no risk of reacting with the gelatin coating 3 of the seamless core 1 or other components such as the enzyme blended in the enzyme blending granule 5, an additive containing any pigment should be used. Also good.

As the fat-soluble active ingredient to be blended in the oil solution containing the fat-soluble active ingredient, any fat-soluble active ingredient other than CoQ ₁₀ may be used as long as it is a fat-soluble active ingredient that can be blended in food and desired to be ingested. Good. Further, any edible oil other than MCT may be used as the edible oil for dissolving CoQ ₁₀ in order to produce the CoQ _10- containing oil liquid 2.

The seamless core 1 may be manufactured by a method other than that described in the above embodiment as long as the CoQ _10- containing oil solution 2 can be included in the uniform gelatin coating 3. In addition, if the enzyme-containing granule 5 can be formed on the surface of the seamless core 1 with a required thickness, a method other than that described in the above embodiment may be adopted. . Of course, various changes can be made without departing from the scope of the present invention.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 shows an embodiment of an enzyme-containing food according to the present invention, in which (A) is a schematic diagram showing a state cut along the central axis of a hard capsule, and (B) shows an enlarged granule of enzyme-containing granules. It is sectional drawing.

Explanation of symbols

1 Seamless core 2 CoQ ₁₀ containing oil solution (oil solution containing fat-soluble substance)
3 Gelatin coating 4 Enzyme-containing coating coating 5 Enzyme-containing granule 6 Hard capsule 7 Zein (stomach-soluble and enteric substance)
8 Enzyme-containing food

Claims (4)

  A fat-soluble active ingredient-containing oil solution obtained by dissolving a fat-soluble active ingredient in edible oil is encapsulated in a gelatin coating to form a seamless nucleus, and the surface of the seamless nucleus is coated with an enzyme-containing coating film containing a required enzyme. An enzyme-containing granule that functions in the intestine, characterized by having a covering structure.   A fat-soluble active ingredient-containing oil solution obtained by dissolving a fat-soluble active ingredient in edible oil is encapsulated in a gelatin coating to form a seamless nucleus, and the surface of the seamless nucleus is coated with an enzyme-containing coating film containing a required enzyme. Covering to form enzyme-containing granules, encapsulating the enzyme-containing granules in a hard capsule, and coating the entire surface of the hard capsule with a gastric insoluble substance and an enteric substance. Enzyme combination food.   The seamless core of the enzyme-blended granule is made into a seamless capsule using the oil solution containing the fat-soluble active ingredient and the gelatin solution for forming the gelatin film, and the required enzymes and excipients are placed on the surface of the seamless core. The enzyme blended food according to claim 2, wherein the powder raw material contained is laminated with a required thickness through a required coating solution to form an enzyme-containing coating film to form enzyme-mixed granules.   Three types of enzyme-containing granules composed of an enzyme-containing coating film, each of which contains a microorganism-derived, plant-derived, or animal-derived enzyme and a pigment of a different color for each of the microorganism-derived, plant-derived, or animal-derived enzymes. The enzyme-containing food according to claim 2 or 3, wherein the three kinds of enzyme-containing granules are formed and mixed in one or more kinds and encapsulated in a hard capsule.

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