CN105640828B - Application of the durian shell extract in oral care product - Google Patents
Application of the durian shell extract in oral care product Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a kind of application of durian shell extract in oral care product, durian shell extract additive amount in oral care product is 0.5%~10%；It is preferred that additive amount is 1.0%~5.0%.The durian shell extract can be applicable in the oral care products such as toothpaste, mouthwash or tooth powder.The present invention provides application scheme of the durian shell extract as oral care product, make this oral care product that there is antibacterial, anti-inflammatory and analgesic activity, to effectively reduce bacteria breed caused by plaque, prevention and alleviate gingivitis, periodontitis and gum pain.
Description
Technical field
The present invention relates to a kind of durian shell extracts, belong to oral care product technical field, more particularly to a kind of tool
There is the application of antibacterial, anti-inflammatory and analgesic activity durian shell extract in oral care product.
Background technology
Intraoral bacterial number is more, broad categories, has pathogenic bacteria, non-pathogenic bacteria and pathogenic bacteria of having ready conditions.Wherein at most,
Most importantly streptococcus, staphylococcus and Bacillus acidi lactici.The more streptococcus anaerobius of the bad people of oral hygiene, wherein the anaerobism that makes a variation
The formation of streptococcus and saprodontia is closely related, which can decompose the sucrose in food and generate big insoluble of high molecular weight, viscosity
Glucan, so that other floras in oral cavity are adhered to dental surface and form bacterial plaque.Plaque refers to being adhered to dental surface
Or the micropopulation on oral soft tissue, it is made of bacterium, mouth desquamated cells and food scraps etc., if removing not in time
Meeting calcification is at calculus dentalis；Calculus dentalis stimulates gingiva tissue, to induce gingivitis or periodontitis；Gingivitis, periodontitis, saprodontia etc.
It can cause to have a toothache again.Therefore pathogenic bacteria are the principal elements to form substantive lesions and develop.Oral care product is oral health
Umbrella, can effectively reduce bacterium growth, remove plaque, keep oral health.
Common oral care product has toothpaste, mouthwash, tooth powder, mouthspray etc., basic function currently on the market
It is cleaning tooth, fresh breath, safeguards oral health.Some declare there is antibacterial or prevention of gingivitis, periodontitis and alleviation
The functional oral care product of dental pain, adds western medicine composition mostly, can be broken while preventing or treating mouth disease
The normal microbial environment in bad oral cavity, is unfavorable for oral health.Natural plant extracts are with the incomparable green of Western medicine, peace
Congruent advantage, therefore, additive has become current market development the effect of using natural plant extracts as oral care product
Trend.
However, application of the durian shell extract of the present invention in oral care product not yet finds to report, exploitation is a kind of
Oral care product with antibacterial, anti-inflammatory and analgesic activity durian shell extract must be with certain market value and city
Field space, a kind of oral care product of natural health is provided for the patient of gingivitis, periodontitis and gum pain.
Invention content
The problem to be solved in the present invention is to provide application scheme of the durian shell extract as oral care product, makes this
Oral care product has antibacterial, anti-inflammatory and analgesic activity, to effectively reduce bacteria breed caused by plaque, prevent it is gentle
Solve gingivitis, periodontitis and gum pain.
The durian shell extract of the present invention is using durian shell extract as antibacterial, resists in the application of oral care product
Scorching and analgesic purpose is added in the oral care products such as toothpaste, mouthwash, tooth powder.
The purpose of the present invention is adopt the following technical scheme that realize：
A kind of application of durian shell extract in oral care product, the durian shell extract is in oral care product
Middle additive amount is respectively 0.5%~10%；It is preferred that additive amount is 1.0%~5.0%.
Described its extracting method of durian shell extract is：
Durian shell is dried and cut into fritter, is 50 by liquid ratio：1 is added 80% ethyl alcohol, heats 90 DEG C and flows back 30 points
Clock, is then concentrated under reduced pressure into durian shell medicinal extract, is ground into powdery after drying and forms durian shell extract.
Described its extracting method of durian shell extract can be carried by supercritical ultrasonics technology, microwave method, supercritical fluid extraction etc.
It can be powdery or extracting solution to take object.
Durian shell extract of the present invention can also be extracting solution, when with extracting solution by taking 100% extract powder as an example
When being applied in oral care product, additive amount in formula should be converted to disclosed in this invention 100% extract powder
Amount.
Application of the durian shell extract in the oral care products such as toothpaste, mouthwash or tooth powder.
A kind of toothpaste of the shell extract containing durian, weight percent of the durian shell extract in toothpaste component are
0.5%~10%, which, which is generally 1.0%~5.0%, is advisable, remaining is toothpaste matrix ingredient, and the matrix components are by weight
Measuring percentage is：15%~45% abrasive, 20%~65% moisturizer, 0.8%~2.0% thickener, 1.5%~
3.0% surfactant, 0.2%~0.5% sweetener, 0.05%~0.5% preservative, 0.5%~2.0% perfume (or spice)
Essence, deionized water are added to 100%.
The abrasive is one or both of calcium carbonate, calcium monohydrogen phosphate, silica mixture；The moisturizer is
One or more mixtures in sorbierite, glycerine, polyethylene glycol, propylene glycol；The thickener is sodium carboxymethylcellulose, Huang
One or more mixtures in virgin rubber, guar gum, carragheen；The surfactant is sldium lauryl sulfate, lauroyl flesh
One or more mixtures in propylhomoserin sodium, sodium lauroyl glutamate, cocoyl glycine betaine；The sweetener be saccharin sodium,
The mixture of one or both of Sucralose；The preservative is one kind in sodium benzoate, methyl hydroxybenzoate, Nipasol
Or a variety of mixtures.
A kind of mouthwash of the shell extract containing durian, weight percent of the durian shell extract in mouthwash raw material
It is 0.5%~10%, which, which is generally 1.0%~5.0%, is advisable, remaining is matrix components, and the matrix components are by weight
The sorbierite that percentage is 25%, 10% ethyl alcohol, 2.0% Tween-60,0.3% saccharin sodium, 0.1% methyl hydroxybenzoate,
0.2% essence, deionized water are added to 100%.
A kind of tooth powder of the shell extract containing durian, weight percent of the durian shell extract in tooth powder raw material are
0.5%~10%, which, which is generally 1.0%~5.0%, is advisable, remaining is matrix components, the matrix components by weight hundred
Divide than the abrasive for 70%, 2.5% sldium lauryl sulfate, 0.3%~0.8% sodium carboxymethylcellulose, 0.3% sugar
Smart sodium, 0.5% sodium benzoate, 1.5% essence, sorbierite are added to 100%.Wherein abrasive is calcium carbonate, phosphoric acid hydrogen
One or more of calcium, silica, aluminium hydroxide, calcium pyrophosphate mix.
By above-mentioned technical proposal, the present invention has the advantages that：
1, the application of durian shell extract of the invention in oral care product mainly utilizes durian shell extract
Antibacterial action inhibits the harmful bacteria in oral cavity, reduces the generation of plaque.
2, using its anti-inflammatory effect, prevent and alleviate the oral inflammations such as gingivitis or periodontitis；Using its analgesic activity, come
Alleviate the gum pain caused by inflammation.
3, durian shell extract of the invention causes oral cavity disease damage caused by plaque and plaque to develop full mistake bacterium
Journey has effective alleviation and inhibiting effect, whole process protection gingivitis caused by plaque, periodontitis and gum pain, Quan Fang
Position protects the health of one's mouth.
Specific implementation mode
Application of the durian shell extract of the present invention in oral care product, exactly when preparing oral care product,
It is added to durian shell extract as antibacterial, anti-inflammatory, analgesic bioactive substance in oral care product.Make people in common oral
While cleaning-nursing, plaque, prevention and alleviation gingivitis, periodontitis and the gum pain of bacteria breed formation are effectively reduced
Effect.
The durian for being known as " king of tropical fruit (tree) " is medicine-food two-purpose fruit, is rich in minerals and trace element.Modern nutrition
It learns the study found that durian nutritive value is high, rich in the trace element such as Ca, K, Fe and a variety of amino acid, often eating can salubrity
It is healthy and strong, invigorating the spleen tonifying Qi, tonifying kidney and strengthening yang, durian property heat can be with promoting blood circulation to remove blood stasis, alleviation dysmenorrhoea.The utilization of durian mainly also stops at present
In terms of staying in pulp, the application study to durian shell is mainly its utilization as application material, to durian shell prevention disease,
The research of medicines and health protection etc. is less, or even is also in initial stage.Modern medicine study show durian shell have antibacterial,
The multiple efficacies such as anti-inflammatory, analgesia, the research with people to durian shell active constituent, durian shell will as functional health product
It is rapidly developed.
Below by specific embodiment, the present invention is further explained, but these embodiments are used only for that it is described in more detail
With, and be not applied to limit the present invention in any form.
Embodiment 1 (application of the durian shell extract in toothpaste)
A kind of toothpaste of the shell extract containing durian, by weight percentage, including following raw material components：
40% calcium carbonate, 5.0% silica, 1.5% sodium carboxymethylcellulose, 0.5% guar gum,
2.5% sldium lauryl sulfate, 0.5% sodium lauroyl sarcosine, 0.1% saccharin sodium, 0.4% Sucralose,
0.03% methyl hydroxybenzoate, 0.02% Nipasol, 2.0% essence, 5.0% polyethylene glycol-400,15% sorb
Alcohol, 0.5% durian extract, deionized water are added to 100%.
The preparation method of the toothpaste of the above-mentioned shell extract containing durian is as follows：
Stirring and dissolving in container A is added after methyl hydroxybenzoate, Nipasol, essence are weighed；Deionized water, durian shell are carried
Take object, saccharin sodium, Sucralose, sodium lauroyl sarcosine that stirring and dissolving in premix pot A is added,
Polyethylene glycol-400, sorbierite are added in premix pot B；By calcium carbonate, silica, sodium carboxymethylcellulose,
Guar gum, sldium lauryl sulfate are added in meal mixer and are uniformly mixed；The liquid material in pot A and premix pot B will be premixed in vacuum state
Then lower sucking Manufacturing medicine extract machine starts scraper plate and stirring, suck the powder in meal mixer, and for powder into complete rear opening homogeneous, homogeneous is de-
Gas 25~30 minutes；After vacuum outgas 25~30 minutes, the raw material in container A is sucked, then homogeneous deaerates 10 minutes, it is qualified to examine
After can go out cream.
Embodiment 2
A kind of toothpaste of the shell extract containing durian, by weight percentage, including following raw material components：
35% calcium monohydrogen phosphate, 5.0% silica, 0.5% sodium carboxymethylcellulose, 0.5% xanthans,
2.2% sldium lauryl sulfate, 0.3% sodium lauroyl glutamate, 0.3% saccharin sodium, 0.3% sodium benzoate, 1.2%
Essence, 5.0% propylene glycol, 10% glycerine, 15% sorbierite, 10% durian extract, deionized water is added to
100%.
The toothpaste preparation method of the shell extract containing durian：
Container A is added after essence is weighed；Deionized water, durian shell extract, saccharin sodium, sodium lauroyl glutamate are added
Enter to premix stirring and dissolving in pot A；Propylene glycol, glycerine, sorbierite are added in premix pot B；By calcium monohydrogen phosphate, silica, carboxylic
Sodium carboxymethylcellulose pyce, xanthans, sldium lauryl sulfate are added in meal mixer and are uniformly mixed；Pot A will be premixed and premix the liquid in pot B
Material sucks Manufacturing medicine extract machine under vacuum conditions, then starts scraper plate and stirring, sucks the powder in meal mixer, and powder is opened afterwards into complete
Homogeneous, homogeneous deaerate 25~30 minutes；After vacuum outgas 25~30 minutes, the raw material in container A is sucked, then homogeneous deaerates 10 points
Clock can go out cream after the assay was approved.
Embodiment 3
A kind of toothpaste of the shell extract containing durian, by weight percentage, including following raw material components：
15% silica, 0.5% sodium carboxymethylcellulose, 0.3% carragheen, 1.0% laruyl alcohol sulfuric acid
Sodium, 0.5% cocoyl glycine betaine, 0.2% saccharin sodium, 0.5% sodium benzoate, 0.5% essence, 2.0% it is poly-
The sorbierite of ethylene glycol -600,63%, 1.0% durian extract, deionized water are added to 100%.
The preparation method of the toothpaste of the above-mentioned shell extract containing durian is as follows：
Container A is added after essence is weighed；Deionized water, durian shell extract, saccharin sodium, cocoyl glycine betaine are added
Enter to premix stirring and dissolving in pot A；Polyethylene glycol -600, sorbierite are added in premix pot B；By silica, carboxymethyl cellulose
Plain sodium, carragheen, sldium lauryl sulfate are added in meal mixer and are uniformly mixed；The liquid material in pot A and premix pot B will be premixed in vacuum
Manufacturing medicine extract machine is sucked under state, then starts scraper plate and stirring, sucks the powder in meal mixer, powder is into complete rear opening homogeneous,
Matter deaerates 25~30 minutes；After vacuum outgas 25~30 minutes, the raw material in container A is sucked, then homogeneous deaerates 10 minutes, examines
Cream can be gone out after qualification.
Embodiment 4
A kind of toothpaste of the shell extract containing durian, by weight percentage, including following raw material components：
25% silica, 0.6% sodium carboxymethylcellulose, 0.2% carragheen, 2.2% laruyl alcohol sulfuric acid
Sodium, 0.25% saccharin sodium, 0.3% sodium benzoate, 1.0% essence, the sorb of 4.0% polyethylene glycol -600,55%
Alcohol, 5.0% durian extract, deionized water are added to 100%.
The preparation method of the toothpaste of the above-mentioned shell extract containing durian is as follows：
Container A is added after essence is weighed；Deionized water, durian shell extract, saccharin sodium are added in premix pot A and stirred
Dissolving；Polyethylene glycol -600, sorbierite are added in premix pot B；By silica, sodium carboxymethylcellulose, carragheen, bay
Alcohol sodium sulphate is added in meal mixer and is uniformly mixed；Pot A will be premixed and premix the liquid material in pot B and suck cream processed under vacuum conditions
Then machine starts scraper plate and stirring, suck the powder in meal mixer, and powder deaerates 25~30 points into complete rear opening homogeneous, homogeneous
Clock；After vacuum outgas 25~30 minutes, the raw material in container A is sucked, then homogeneous deaerates 10 minutes, can go out after the assay was approved
Cream.
Embodiment 5 (application of the durian shell extract in mouthwash)
A kind of mouthwash containing durian shell extract, by weight percentage, including following each raw material component：
25% sorbierite, 10% ethyl alcohol, 2.0% Tween-60,0.3% saccharin sodium, 0.1% methyl hydroxybenzoate,
0.2% essence, 0.5% durian shell extract, deionized water are added to 100%.
The preparation method of the mouthwash of the above-mentioned shell extract containing durian is as follows：
Stirring and dissolving in container A first is added in methyl hydroxybenzoate, essence, ethyl alcohol；By deionized water, sorbierite, Tween-60,
Stirring and dissolving in container B is added in saccharin sodium, durian shell extract；Then container B is added in the raw material in container A under stiring
In, transparent rear standing is stirred, is packed after sample detection qualification.
Embodiment 6
A kind of mouthwash containing durian shell extract, by weight percentage, including following raw material components：
25% sorbierite, 10% ethyl alcohol, 2.0% Tween-60,0.3% saccharin sodium, 0.1% methyl hydroxybenzoate,
0.2% essence, 10% durian shell extract, deionized water are added to 100%.
The mouthwash preparation method of the shell extract containing durian：With the present embodiment 5.
Embodiment 7
A kind of mouthwash containing durian shell extract, by weight percentage, including following raw material components：
25% sorbierite, 10% ethyl alcohol, 2.0% Tween-60,0.3% saccharin sodium, 0.1% methyl hydroxybenzoate,
0.2% essence, 1.0% durian shell extract, deionized water are added to 100%.
The mouthwash preparation method of the shell extract containing durian：With the present embodiment 5.
Embodiment 8
A kind of mouthwash containing durian shell extract, by weight percentage, including following raw material components：
25% sorbierite, 10% ethyl alcohol, 2.0% Tween-60,0.3% saccharin sodium, 0.1% methyl hydroxybenzoate,
0.2% essence, 5.0% durian shell extract, deionized water are added to 100%.
The mouthwash preparation method of the shell extract containing durian：With the present embodiment 5.
Embodiment 9 (application of the durian shell extract in tooth powder)
A kind of tooth powder containing durian shell extract, by weight percentage, including following raw material components：
60% calcium carbonate, 10% silica, 2.5% sldium lauryl sulfate, 0.3%~0.8% carboxymethyl
Sodium cellulosate, 0.3% saccharin sodium, 0.5% sodium benzoate, 1.5% essence, 0.5% durian shell extract, sorbierite
It is added to 100%.
The preparation method of the tooth powder of the above-mentioned shell extract containing durian is as follows：
Calcium carbonate, silica, sldium lauryl sulfate, sodium carboxymethylcellulose, sodium benzoate, durian shell extract are added
Enter to stir in meal mixer 10 minutes, the lysate that saccharin sodium and sorbierite is then added stirs 20 minutes, is eventually adding essence and stirs
It mixes and stops after twenty minutes, discharge after sample detection qualification.
Embodiment 10
A kind of tooth powder containing durian shell extract, by weight percentage, including following raw material components：
65% calcium monohydrogen phosphate, 5% silica, 2.5% sldium lauryl sulfate, 0.3%~0.8% carboxymethyl
Sodium cellulosate, 0.3% saccharin sodium, 0.5% sodium benzoate, 1.5% essence, 10% durian shell extract, sorbierite
It is added to 100%.
The preparation method of the tooth powder of the above-mentioned shell extract containing durian is as follows：
By calcium monohydrogen phosphate, silica, sldium lauryl sulfate, sodium carboxymethylcellulose, sodium benzoate, durian shell extract
It is added in meal mixer and stirs 10 minutes, the lysate that saccharin sodium and sorbierite is then added stirs 20 minutes, is eventually adding essence
Stirring stops after twenty minutes, discharges after sample detection qualification.
Embodiment 11
A kind of tooth powder containing durian shell extract, by weight percentage, including following raw material components：
60% calcium pyrophosphate, 10% silica, 2.5% sldium lauryl sulfate, 0.3%~0.8% carboxylic first
Base sodium cellulosate, 0.3% saccharin sodium, 0.5% sodium benzoate, 1.5% essence, 1.0% durian shell extract, sorb
Alcohol is added to 100%.
The preparation method of the tooth powder of the above-mentioned shell extract containing durian is as follows：
By calcium pyrophosphate, silica, sldium lauryl sulfate, sodium carboxymethylcellulose, sodium benzoate, durian shell extract
It is added in meal mixer and stirs 10 minutes, the lysate that saccharin sodium and sorbierite is then added stirs 20 minutes, is eventually adding essence
Stirring stops after twenty minutes, discharges after sample detection qualification.
Embodiment 12
A kind of tooth powder containing durian shell extract, by weight percentage, including following raw material components：
65% aluminium hydroxide, 5% silica, 2.5% sldium lauryl sulfate, 0.3%~0.8% carboxymethyl
Sodium cellulosate, 0.3% saccharin sodium, 0.5% sodium benzoate, 1.5% essence, 5.0% durian shell extract, sorbierite
It is added to 100%.
The preparation method of the tooth powder of the above-mentioned shell extract containing durian is as follows：
By aluminium hydroxide, silica, sldium lauryl sulfate, sodium carboxymethylcellulose, sodium benzoate, durian shell extract
It is added in meal mixer and stirs 10 minutes, the lysate that saccharin sodium and sorbierite is then added stirs 20 minutes, is eventually adding essence
Stirring stops after twenty minutes, discharges after sample detection qualification.
Effete test embodiment
Clinical test part：
Experimental example 1 (toothpaste antibacterial experiment)
Using the toothpaste of the embodiment of the present invention 1 and 1 base cream of the embodiment without durian shell extract is as experimental subjects, takes mouth
The common pathogenic bacteria of intracavitary are as antibacterial object, with caseinhydrolysate fluid nutrient medium in 35 DEG C of constant temperature incubations, in different toothpaste
Bacteriostasis property under sample concentration.Experimental result is as shown in table 1 below.
Bacteriostatic experiment of 1 toothpaste of table to pathogenic bacteria
| Strain | 1：10 | 1：200 | 1：300 | 1：500 |
| Streptococcus mutans | Asepsis growth | Asepsis growth | Asepsis growth | There is bacterium growth |
| Porphyromonas gingivalis | Asepsis growth | Asepsis growth | Asepsis growth | There is bacterium growth |
| Saccharomyces albicans | Asepsis growth | Asepsis growth | Asepsis growth | There is bacterium growth |
Upper table illustrates that the toothpaste of the present invention has good inhibition to oral cavity common pathogen.
Experimental example 2 (evaluation of toothpaste anti-inflammatory efficacy)
Experimental method：Using the anti-inflammation test method of paraxylene induced mice auricle acute inflammation swelling
40 healthy male KM mouse, 18~22g of weight are taken to be randomly divided into 4 groups, every group 10.Blank control group (physiology
Brine 0.2ml/ is only), toothpaste blank control group (is free of durian shell extract, other proportionings are prepared by embodiment 2, and 0.1g/ is only),
Experimental group (is prepared, 0.1g/ is only) by embodiment 2, positive controls (dexamethasone tablet, specification 0.75mg/ pieces, 0.05g/ is only).
Administration route is gastric infusion, 1 time a day, successive administration 7 days, 30 minutes after last time is administered, every mouse right ear exterior feature
Inside and outside two sides uniformly smears dimethylbenzene 0.1ml/ and only causes inflammation, and left ear is untreated to make self-blank control.In to dimethylbenzene 1 hour
After put to death mouse, cut ears, be aligned, lay auricle with the card punch of 8mm, weighed with assay balance, calculate swelling value：Swelling
Value=auris dextra weight-left ear weight, data are analyzed by SPPS10.0 statistical softwares, the results are shown in Table 2.
2 toothpaste sample paraxylene of table causes the influence of Mice Auricle acute inflammation swelling
| Group | Dosage | Swelling value (mg) |
| Blank control group | Physiological saline 0.2ml/ is only | 15.63±3.75 |
| Toothpaste blank control group | 0.1g/ is only | 15.35±3.54*△ |
| Experimental group | 0.1g/ is only | 11.32±2.41**△△ |
| Positive controls | Dexamethasone 0.05g/ is only | 9.49±2.23***△△△ |
Compared with blank control group：* P ＜ 0.05, * * P ＜ 0.01, * * * P ＜ 0.001, compared with toothpaste blank control group：
△ P ＜ 0.05, △ △ P ＜ 0.01, △ △ △ P ＜ 0.001.
The experimental results showed that toothpaste sample and dexamethasone can be such that chmice acute inflammation swelling auricle weight significantly subtracts
It is few, there is apparent inhibition dimethylbenzene induced mice auricle inflammation swelling, show that there is apparent anti-inflammatory effect to acute inflammation.
Experimental example 3 (evaluation of toothpaste analgesic efficacy)
Experimental method：Using the inhibition test method of Dichlorodiphenyl Acetate induced mice pain writhing response：
40 healthy male KM mouse, 18~22g of weight are taken to be randomly divided into 4 groups, every group 10, be divided into toothpaste high dose
Group (embodiment 3,2mg/10g), toothpaste low dose group (embodiment 3,0.5mg/10g), negative control group (physiological saline 0.1ml/
10g), positive controls (analgin 0.5mg/10g).Gastric infusion respectively, after twenty minutes, every group of mouse difference abdominal cavity is noted for administration
Penetrate 0.6% acetum 0.1ml/10g, mouse writhing reaction times (stretch by abdomen indent, trunk and retrogressing in record 20 minutes
Open, buttocks is raised), and writhing response incubation period for the first time, calculate each group analgesia percentage.
Analgesia percentage=(negative control group writhing number-administration group writhing number)/negative control group writhing number ×
100%
As a result it see the table below shown in 3.
3 Dichlorodiphenyl Acetate induced mice pain writhing response of table analgesia percentage
| Group | Sample size | Dosage | Ease pain percentage |
| Negative control group | 10 | 0.1ml/10g | 28.75±4.47 |
| Positive controls | 10 | 0.5mg/10g | 17.75±6.31** |
| High dose group | 10 | 2mg/10g | 13.37±5.71*** |
| Low dose group | 10 | 0.5mg/10g | 10.01±4.65*** |
Compared with negative control group：* P ＜ 0.05, * * P ＜ 0.01, * * * P ＜ 0.001,
The experimental results showed that toothpaste sample and analgin can make mouse have significant analgesic activity.
Experimental example 4 (evaluation of toothpaste clinical efficacy)
The patient for respectively choosing 30 gingivitis and gum pain is subjects, is randomly divided into gingivitis group and gum pain
Group is at least brushed teeth 2 times daily using the toothpaste of embodiment 3,3 minutes every time, after being used continuously 30 days, is counted to effect,
As a result as shown in table 4 below.
4 toothpaste of table counts gingivitis and gum pain clinical effectiveness
| Group | Number | It is effective | Effectively | In vain | Efficient (%) |
| Gingivitis group | 30 | 10 | 18 | 2 | 93.3% |
| Gum pain group | 30 | 8 | 18 | 4 | 86.7% |
With 4 statistical description of upper table, toothpaste of the invention improves significantly to gingivitis and gum pain tool, reaches
Expected purpose of the present invention.
Utility efficiency is carried out to embodiment mouthwash and tooth powder simultaneously to show：The mouthwash and tooth powder of the shell extract containing durian
Equally improve significantly to gingivitis and gum pain tool.
The above described is only a preferred embodiment of the present invention, be not intended to limit the present invention in any form, therefore
It is every without departing from technical solution of the present invention content, simply repaiied to any made by above example according to the technical essence of the invention
Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.
Claims (9)
1. a kind of application of durian shell extract in preparing oral care product, it is characterised in that：The durian shell extract
Additive amount is 0.5%~10% in oral care product；Described its extracting method of durian shell extract is：
Durian shell is dried and cut into fritter, is 50 by liquid ratio：1 is added 80% ethyl alcohol, heats 90 DEG C and flows back 30 minutes, so
After durian shell medicinal extract is concentrated under reduced pressure into, be ground into after drying powdery form durian shell extract.
2. application according to claim 1, it is characterised in that：The durian shell extract adds in oral care product
Amount is 1.0%~5.0%.
3. application according to claim 1, it is characterised in that：Described its extracting method of durian shell extract passes through ultrasonic wave
Method, microwave method or supercritical fluid extraction, extract are powdery or extracting solution.
4. application according to claim 1, it is characterised in that：The durian shell extract is in toothpaste, mouthwash or tooth powder
Oral care product in application.
5. application according to claim 4, it is characterised in that：The toothpaste includes durian shell extract and matrix components；
Weight percent of the durian shell extract in raw material of toothpaste is 1.0%~5.0%, remaining is matrix components, the base
Matter ingredient is by weight percentage：15%~45% abrasive, 20%~65% moisturizer, 0.8%~2.0% thickening
Agent, 1.5%~3.0% surfactant, 0.2%~0.5% sweetener, 0.05%~0.5% preservative, 0.5%
~2.0% essence, deionized water are added to 100% and are formed.
6. application according to claim 5, it is characterised in that：The abrasive is calcium carbonate, calcium monohydrogen phosphate, silica
One or both of mixture；The moisturizer is one or more mixed in sorbierite, glycerine, polyethylene glycol, propylene glycol
Close object；The thickener is one or more mixtures in sodium carboxymethylcellulose, xanthans, guar gum, carragheen；It is described
Surfactant is one kind in sldium lauryl sulfate, sodium lauroyl sarcosine, sodium lauroyl glutamate, cocoyl glycine betaine
Or a variety of mixtures；The sweetener is the mixture of one or both of saccharin sodium, Sucralose；The preservative is benzene
One or more mixtures in sodium formate, methyl hydroxybenzoate, Nipasol.
7. application according to claim 4, it is characterised in that：The mouthwash include durian shell extract and matrix at
Point；Weight percent of the durian shell extract in mouthwash raw material is 1.0%~5.0%, remaining is matrix components, institute
State matrix components by weight percentage be 25% sorbierite, 10% ethyl alcohol, 2.0% Tween-60,0.3% saccharin sodium,
0.1% methyl hydroxybenzoate, 0.2% essence, deionized water are added to 100% and are formed.
8. application according to claim 4, it is characterised in that：The tooth powder includes durian shell extract and matrix components；
Weight percent of the durian shell extract in tooth powder raw material is 1.0%~5.0%, remaining is matrix components, the base
Matter ingredient is 70% abrasive, 2.5% sldium lauryl sulfate, 0.3%~0.8% carboxymethyl cellulose by weight percentage
Plain sodium, 0.3% saccharin sodium, 0.5% sodium benzoate, 1.5% essence, sorbierite are added to 100% and are formed.
9. application according to claim 8, it is characterised in that：The abrasive is calcium carbonate, calcium monohydrogen phosphate, titanium dioxide
The mixing of one or more of silicon, aluminium hydroxide, calcium pyrophosphate.
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| BE1024938B1 (en) * | 2017-01-25 | 2018-08-27 | Living Technologies Coöperatieve Vennootschap Met Beperkte Aansprakelijkheid | Method for cleaning surfaces in interior spaces and in technical installations |
| CN106983681A (en) * | 2017-03-03 | 2017-07-28 | 吕良德 | A kind of toothpaste containing natural rubbing agent |
| CN112022885A (en) * | 2020-05-09 | 2020-12-04 | 扬州工业职业技术学院 | Durian shell extracting solution, preparation method thereof and antibacterial mask |
| CN111671679A (en) * | 2020-08-05 | 2020-09-18 | 广东工业大学 | Durian shell essential oil hand cream and preparation method thereof |
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| CN101244016A (en) * | 2008-03-17 | 2008-08-20 | 柳州两面针股份有限公司 | Application of aurantiin in preparing oral cavity nursing health products |
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| US20070042064A1 (en) * | 2005-08-19 | 2007-02-22 | Access Business Group International Llc | Extracts of durian fruit for use in skin care compositions |
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| CN101244016A (en) * | 2008-03-17 | 2008-08-20 | 柳州两面针股份有限公司 | Application of aurantiin in preparing oral cavity nursing health products |
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| 《榴莲壳提取物的制备及其抗炎镇痛作用的研究》;吴敏芝;《中国优秀硕士学位论文全文数据库.医药卫生科技辑》;20110415(第4期);摘要第III页"抗炎实验结果""镇痛实验结果""抗菌实验结果"，第10页第1段，第11页2.2.1回流法，第17页表2-8 * |
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Effective date of registration: 20221025 Address after: 515834 Liannan Industrial Zone, Chenghai District, Shantou City, Guangdong Province Patentee after: Guangdong Mingchen Daily Chemical Co.,Ltd. Address before: 515834 Liannan Industrial Zone, Lianxia Town, Chenghai District, Shantou City, Guangdong Province Patentee before: MINGCHEN HEALTH Co.,Ltd. |
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