CN101095868A - Medicine composition for treating colitis and method of making the same - Google Patents
Medicine composition for treating colitis and method of making the same Download PDFInfo
- Publication number
- CN101095868A CN101095868A CNA2006100128710A CN200610012871A CN101095868A CN 101095868 A CN101095868 A CN 101095868A CN A2006100128710 A CNA2006100128710 A CN A2006100128710A CN 200610012871 A CN200610012871 A CN 200610012871A CN 101095868 A CN101095868 A CN 101095868A
- Authority
- CN
- China
- Prior art keywords
- restrains
- radix
- grams
- pharmaceutical composition
- root
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a pharmaceutical composition for treating colitis and its preparing process, wherein the medicinal composition is prepared from pseudostellaria root 25-35g, white atractylodes rhizome 10-15g, dried orange peel 5-9g, poria cocos wolf 12-15g, licorice root 3-8g, coix seed 25-35g, slices of aconite 8-12g, root of herbaceous peony 10-20g, coptis root 1-5g, prepared dark Japanese plum 8-12g, ledebouriella root 8-12g, kudzuvine root 8-12g, rifampicin 1-5g, pipemidic acid 4-8g and metronidazole 7-11g through steps of disintegrating, mixing, sieving, and making into various preparation, in particular capsules by the conventional preparing method.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of colitis and preparation method thereof, relate in particular to a kind of pharmaceutical composition of the treatment colitis made from traditional Chinese herbal medicine and Western medicine raw material.
Background technology
Chronic colitis belongs to that the traditional Chinese medical science " is had loose bowels ", " sharp disease ", " hemorrhoidal hamorrhage " category, belongs to chronic gastroenteritis, chronic colitis, the allergic colitis of modern medicine, belongs to that reason such as bowel dysfunction causes, and primary disease talks easily, controls very thorny.Chronic colitis is old, young, few commonly encountered diseases, frequently-occurring disease.
Common have Diphenoxylate Mixture of hydrochloride with atropine sulfate, a gentamycin sulfate and bismuth subcarbonate capsules etc., Drug therapy, and curative effect is slow, weak effect, and recurrence easily, or have toxic and side effects.
Summary of the invention
The purpose of this invention is to provide a kind of pharmaceutical composition for the treatment of colitis and preparation method thereof, a kind of pharmaceutical composition of the treatment chronic enteritis made from Chinese herbal medicine and Western medicine raw material especially is provided, overcome the shortcoming of said medicine.
The objective of the invention is to be achieved through the following technical solutions:
A kind of pharmaceutical composition for the treatment of colitis is characterized in that composition and proportioning: Radix Pseudostellariae 25-35 restrains, Rhizoma Atractylodis Macrocephalae (parched) 10-15 restrains, Pericarpium Citri Reticulatae 5-9 restrains, Poria 12-15 restrains, Radix Glycyrrhizae 3-8 restrains, stir-fry Semen Coicis 25-35 restrains, Radix Aconiti Lateralis Preparata 8-12 restrains, Radix Paeoniae Alba 10-20 restrains, Rhizoma Coptidis 1-5 restrains, Fructus Mume 8-12 restrains, Radix Saposhnikoviae 8-12 restrains, Radix Puerariae 8-12 restrains, rifampicin 1-5 restrains, pipemidic acid 4-8 restrains, metronidazole 7-11 restrains.
Further, Radix Pseudostellariae 30 restrains, Rhizoma Atractylodis Macrocephalae (parched) 12 restrains, Pericarpium Citri Reticulatae 6 restrains, Poria 10 restrains, Radix Glycyrrhizae 5 restrains, stir-fry Semen Coicis 30 restrains, Radix Aconiti Lateralis Preparata 10 restrains, the Radix Paeoniae Alba 15 restrains, Rhizoma Coptidis 3 restrains, Fructus Mume 10 restrains, Radix Saposhnikoviae 10 restrains, Radix Puerariae 10 restrains, rifampicin 3 restrains, pipemidic acid 6 restrains, metronidazole 9 restrains.
The preparation of described pharmaceutical composition is capsule, pill, tablet or granule.
The present invention also provides the method for compositions of the described treatment colitis of preparation, may further comprise the steps: take by weighing Radix Pseudostellariae, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Poria, Radix Glycyrrhizae, stir-fry Semen Coicis, Radix Aconiti Lateralis Preparata, the Radix Paeoniae Alba, Rhizoma Coptidis, Fructus Mume, Radix Saposhnikoviae, Radix Puerariae, rifampicin, pipemidic acid, metronidazole in the described arbitrary ratio of claim 1-2, pulverize, mix, sieve, the preparation method is made various preparations routinely again.
Rifampicin is lifumeisu (antibiotic that Streptothrix produces), and lifumeisu reduces through vitamin C in sulphuric acid, and gets with the one 4 one aminopiperazine condensations of 1 monomethyl.
Pipemidic acid is a carbostyril family antibacterial drugs, has stronger effect to killing or suppressing microorganism.
Metronidazole has another name called nitre hydroxyl second azoles, is antiprotozoal drug.
Raw material of the present invention all can be purchased in market.
Medicine of the present invention is based on that following mechanism is prepared from: medicine of the present invention is the compound preparation of making in conjunction with modern medicine on the basis of Traditional Chinese medical theory.Its mechanism is:
The Main Ingredients and Appearance of this medicine is a Chinese medicine, Chinese materia medica discuss have invigorate blood circulation, relieve the pain, the function of granulation promoting, skin ulcer is closed up, clinical observation is effective equally to the gastrointestinal ulceration inflammation, modern medicine study thinks that Chinese medicine has extremely strong covering power to gastrointestinal mucosa, can become the barrier of mucosa, and fixing enterovirus, antibacterial and toxin thereof impel the mucosa infection reparation.
Rifampicin, metronidazole, pipemidic acid can suppress to kill sharp Shigella, cholera bacteria, salmonella, Non-cholera vibrio, crooked bacterium and enterobacteria strongly in this medicine, assist Olibanum, Myrrha to kill and remove mucosa antibacterial, toxin, impel the human body rehabilitation.This medicine is an Integrative Chinese-Western, acts synergistically on gastrointestinal gland parietal cell, has suppressed gastrointestinal secretion, has strengthened hemostasis, pain relieving, antimicrobial function; Stimulated the gastrointestinal hypodermal cell, the healing of ulcer surface has been quickened in the hypertrophy of epithelial cell tissue, division.After this medicine Integrative Chinese-Western, the immunity of collaborative adjusting human body has suppressed inflammation and immunoreation, has alleviated signs of toxicity, has improved intestinal environment, has promoted the absorption of inflammation, particularly share back antimicrbial power multiplication, and immunity strengthens, and has obtained curative effect preferably.
On probation by clinical observation: this medicine is efficient, safety, and addiction is not difficult for recurrence after healing, and is fit to out-patient treatment, worth clinical expansion.Pharmacological action shows that this medicine all has good antibacterial efficacy to sharp Shigella and other pathogenic entero becteria, mainly is applicable to treatment acute/chronic colitis, bacillary dysentery, enteritis, Anaphylaxis enteritis, refrigerator enteritis etc.
For proving therapeutic effect of the present invention, carried out following clinical trial: select the embodiment of the invention 1 Drug therapy colitis 2lO example for use, clinical observation, the satisfaction of producing effects.
1, clinical data-210 patient is the out-patient between year July in January, 1999 to 2003, meets national chronic diarrhea academic discussion case choice criteria in 1986.Wherein, the treatment group: male 120 examples, women 90 examples, in age 9-75 year, the course of disease is the shortest 2 months, and is the longest 30 years; Matched group: male 80 examples, women 30 examples, in age 12-67 year, the course of disease is the shortest 1 month, and is the longest 20 years; Two groups have comparability.
2, Therapeutic Method
The treatment group: give every 0.5g of embodiment 1 capsule, each 6, every day three times, one after each meal, this medicine is to quinolone medicine allergy sufferers forbidding, and infant is forbidden; Routed intestinal of hepatic and kidney function obstacle person, hypertension, diabetes, stomach and duodenum and the careful usefulness of heart failure; After taking medicine, urinating rubescent is the medicine normal reaction.
Matched group: 2 of Diphenoxylate Mixture of hydrochloride with atropine sulfate, every day three times; 4 of gentamycin sulfate and bismuth subcarbonate capsules, every day 1 time.Two groups is a course of treatment with lO day all, serve on 2 courses of treatment, estimates therapeutic effect.Observe times of defecation, character every day during the treatment.
3, therapeutic effect
3.1 efficacy assessment standard, referring to " diagnosis of common case and curative effect determinate standard " (the 1st edition,
Wu Shaozhen etc., Beijing, China Traditional Chinese Medicine Publishing House, 1999,305-306) cure: transference cure, defecation is normal, above nothing recurrence in January; Produce effects: transference cure, the recurrence once more of suffering from cold; Effectively: the defecation of taking medicine is normal, the abnormal defecation of not taking medicine; Invalid: symptom after taking medicine does not all have improvement.
3.2 therapeutic effect
Table 1 Drug therapy chronic enteritis of the present invention effect
| Group | The example number | Cure | Produce effects | Effectively | Invalid | Effective percentage % |
| Treatment group matched group | 210 110 | 145 27 | 35 23 | 25 20 | 5 40 | 97.6％ 36.36 |
4, model case
Lee, the man, 47 years old, on March 12nd, 1999 was with the colitis first visit, private prosecution stomachache, diarrhoea outbreak more than 20 year, sometimes in anxious state of mind, feed, when greasy, loose stool has mucus in just, light every day 2.3 times then, to have a pain under the umbilicus before dawn sometimes heavy then every day 6-7 time, borborygmus are promptly let out; Eat a little Western medicine, Chinese patent medicine, the time heavy when light, touching difficulty is more.The pallor of having a medical check-up cold extremities, physical fatigue and lassitude of spirit, indigestion and loss of appetite, abdominal part is latent has a pain, and examines its deep-thready pulse, the tongue skin is light, and is white greasy, control with: the present invention for oral administration is above-mentioned, takes medicine 10 days, and symptom is clearly better, and takes medicine again lO days, and all diseases disappear, and recovery from illness is followed up a case by regular visits to so far, recurrence again.
The specific embodiment
Embodiment 1 capsule
Take by weighing following medicine material: Radix Pseudostellariae 25 restrains, Rhizoma Atractylodis Macrocephalae (parched) 10 restrains, Pericarpium Citri Reticulatae 5 restrains, Poria 12 restrains, Radix Glycyrrhizae 3 restrains, stir-fry Semen Coicis 25 restrains, Radix Aconiti Lateralis Preparata 8 restrains, the Radix Paeoniae Alba 10 restrains, Rhizoma Coptidis 1 restrains, Fructus Mume 8 restrains, Radix Saposhnikoviae 8 restrains, Radix Puerariae 8 restrains, rifampicin 1 restrains, pipemidic acid 4 restrains, metronidazole 7 restrains.Pulverize, mix, 100 orders that sieve, encapsulated, ultraviolet is sterilized promptly.
Specification: O.5g * 100.Usage and consumption: oral; Every day three times, each 6, one after each meal, or follow the doctor's advice.
Embodiment 2 capsules
Take by weighing following medicine material: Radix Pseudostellariae 35 restrains, Rhizoma Atractylodis Macrocephalae (parched) 15 restrains, Pericarpium Citri Reticulatae 9 restrains, Poria 15 restrains, Radix Glycyrrhizae 8 restrains, stir-fry Semen Coicis 35 restrains, Radix Aconiti Lateralis Preparata 12 restrains, the Radix Paeoniae Alba 20 restrains, Rhizoma Coptidis 5 restrains, Fructus Mume 12 restrains, Radix Saposhnikoviae 12 restrains, Radix Puerariae 2 restrains, rifampicin 5 restrains, pipemidic acid 8 restrains, metronidazole 11 restrains.Preparation method: with embodiment 1.
Embodiment 3 tablets
Take by weighing following medicine material: Radix Pseudostellariae 30 restrains, Rhizoma Atractylodis Macrocephalae (parched) 12 restrains, Pericarpium Citri Reticulatae 6 restrains, Poria 10 restrains, Radix Glycyrrhizae 5 restrains, stir-fry Semen Coicis 30 restrains, Radix Aconiti Lateralis Preparata 10 restrains, the Radix Paeoniae Alba 15 restrains, Rhizoma Coptidis 3 restrains, Fructus Mume 10 restrains, Radix Saposhnikoviae 10 restrains, Radix Puerariae 10 restrains, rifampicin 3 restrains, pipemidic acid 6 restrains, metronidazole 9 restrains.Preparation method: take by weighing according to the above ratio, pulverize, mix, 60% ethanol granulate is crossed 14 mesh sieves, adds magnesium stearate 200g, and tablet forming promptly behind the abundant mix homogeneously.
Embodiment 4 pills
Take by weighing following medicine material: Radix Pseudostellariae 30 restrains, Rhizoma Atractylodis Macrocephalae (parched) 12 restrains, Pericarpium Citri Reticulatae 6 restrains, Poria 10 restrains, Radix Glycyrrhizae 5 restrains, stir-fry Semen Coicis 30 restrains, Radix Aconiti Lateralis Preparata 10 restrains, the Radix Paeoniae Alba 15 restrains, Rhizoma Coptidis 3 restrains, Fructus Mume 10 restrains, Radix Saposhnikoviae 10 restrains, Radix Puerariae 10 restrains, rifampicin 3 restrains, pipemidic acid 6 restrains, metronidazole 9 restrains.Preparation method: take by weighing pulverizing according to the above ratio, mix,, cross 200 mesh sieves with 60% ethanol granulate, tablet forming, sugar coating, sterilization, promptly.
Embodiment 5 granules
Take by weighing following medicine material: Radix Pseudostellariae 30 restrains, Rhizoma Atractylodis Macrocephalae (parched) 12 restrains, Pericarpium Citri Reticulatae 6 restrains, Poria 10 restrains, Radix Glycyrrhizae 5 restrains, stir-fry Semen Coicis 30 restrains, Radix Aconiti Lateralis Preparata 10 restrains, the Radix Paeoniae Alba 15 restrains, Rhizoma Coptidis 3 restrains, Fructus Mume 10 restrains, Radix Saposhnikoviae 10 restrains, Radix Puerariae 10 restrains, rifampicin 3 restrains, pipemidic acid 6 restrains, metronidazole 9 restrains.Preparation method: by above-mentioned pulverizing, mix, make granule, cross the lO mesh sieve with 55% ethanol, packing, sterilization, promptly.
Claims (4)
1, a kind of pharmaceutical composition for the treatment of colitis is characterized in that composition and proportioning: Radix Pseudostellariae 25-35 restrains, Rhizoma Atractylodis Macrocephalae (parched) 10-15 restrains, Pericarpium Citri Reticulatae 5-9 restrains, Poria 12-15 restrains, Radix Glycyrrhizae 3-8 restrains, stir-fry Semen Coicis 25-35 restrains, Radix Aconiti Lateralis Preparata 8-12 restrains, Radix Paeoniae Alba 10-20 restrains, Rhizoma Coptidis 1-5 restrains, Fructus Mume 8-12 restrains, Radix Saposhnikoviae 8-12 restrains, Radix Puerariae 8-12 restrains, rifampicin 1-5 restrains, pipemidic acid 4-8 restrains, metronidazole 7-11 restrains.
2, the pharmaceutical composition of treatment colitis according to claim 1 is characterized in that Radix Pseudostellariae 30 grams, Rhizoma Atractylodis Macrocephalae (parched) 12 grams, Pericarpium Citri Reticulatae 6 grams, Poria 10 grams, Radix Glycyrrhizae 5 grams, fries Semen Coicis 30 grams, Radix Aconiti Lateralis Preparata 10 grams, the Radix Paeoniae Alba 15 grams, Rhizoma Coptidis 3 grams, Fructus Mume 10 grams, Radix Saposhnikoviae 10 grams, Radix Puerariae 10 grams, rifampicin 3 grams, pipemidic acid 6 grams, metronidazole 9 grams.
3, the pharmaceutical composition of treatment colitis according to claim 1 and 2, the preparation that it is characterized in that described pharmaceutical composition is capsule, pill, tablet or granule.
4, a kind of method for preparing the described arbitrary pharmaceutical composition of claim 1-3, may further comprise the steps: take by weighing Radix Pseudostellariae, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Poria, Radix Glycyrrhizae, stir-fry Semen Coicis, Radix Aconiti Lateralis Preparata, the Radix Paeoniae Alba, Rhizoma Coptidis, Fructus Mume, Radix Saposhnikoviae, Radix Puerariae, rifampicin, pipemidic acid, metronidazole in the described arbitrary ratio of claim 1-2, pulverize, mix, sieve, the preparation method is made various preparations routinely again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100128710A CN101095868A (en) | 2006-06-26 | 2006-06-26 | Medicine composition for treating colitis and method of making the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100128710A CN101095868A (en) | 2006-06-26 | 2006-06-26 | Medicine composition for treating colitis and method of making the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101095868A true CN101095868A (en) | 2008-01-02 |
Family
ID=39010090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006100128710A Pending CN101095868A (en) | 2006-06-26 | 2006-06-26 | Medicine composition for treating colitis and method of making the same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101095868A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101785844A (en) * | 2010-02-28 | 2010-07-28 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine combination and preparation method thereof for dysentery treatment |
| CN102302589A (en) * | 2011-08-12 | 2012-01-04 | 陈丽英 | Chinese medicinal composition for treating diarrhea irritable bowel syndrome and preparation method thereof |
| CN111228418A (en) * | 2018-11-12 | 2020-06-05 | 张洪军 | Traditional Chinese medicine and western medicine combined enteritis peaching formula and preparation method |
| CN113813365A (en) * | 2021-10-22 | 2021-12-21 | 成都普睿法药物研发有限公司 | Application of radix pseudostellariae cyclic peptide B in preparation of anti-ulcerative colitis medicine |
-
2006
- 2006-06-26 CN CNA2006100128710A patent/CN101095868A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101785844A (en) * | 2010-02-28 | 2010-07-28 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine combination and preparation method thereof for dysentery treatment |
| CN101785844B (en) * | 2010-02-28 | 2011-09-14 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine combination and preparation method thereof for dysentery treatment |
| CN102302589A (en) * | 2011-08-12 | 2012-01-04 | 陈丽英 | Chinese medicinal composition for treating diarrhea irritable bowel syndrome and preparation method thereof |
| CN111228418A (en) * | 2018-11-12 | 2020-06-05 | 张洪军 | Traditional Chinese medicine and western medicine combined enteritis peaching formula and preparation method |
| CN113813365A (en) * | 2021-10-22 | 2021-12-21 | 成都普睿法药物研发有限公司 | Application of radix pseudostellariae cyclic peptide B in preparation of anti-ulcerative colitis medicine |
| CN113813365B (en) * | 2021-10-22 | 2023-09-22 | 成都普睿法药物研发有限公司 | Application of radix pseudostellariae cyclic peptide B in preparation of anti-ulcerative colitis medicines |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101461911B (en) | Chinese medicine oral capsule for treating gout | |
| CN101985026B (en) | Pure Chinese medicinal preparation for rapidly treating halitosis | |
| CN101757566A (en) | Traditional Chinese medicine composition for treating colon cancer and preparation method thereof | |
| CN102698123A (en) | Traditional Chinese medicinal composition for treating transmissible gastroenteritis of swine, feed, preparation method and application thereof | |
| CN101249235B (en) | Chinese medicine for curing esophagus cancer and method of preparing the same | |
| CN101703684B (en) | Medicament for treating allergic purpura and preparation method thereof | |
| CN103301400A (en) | Traditional Chinese medicinal composition for treating chronic atrophic gastritis and preparation method of traditional Chinese medicinal composition | |
| CN101095868A (en) | Medicine composition for treating colitis and method of making the same | |
| CN103055076B (en) | Pure Chinese medicinal composition for treating nosemosis of bees and preparation method of pure Chinese medicinal composition | |
| CN102078549B (en) | Traditional Chinese medicine for treating oxyuriasis | |
| CN100579544C (en) | Chinese medicament preparation for treating cholecystitis and gall-stone as well as preparation method thereof | |
| CN101204554B (en) | Medicaments composite for stomach illness and preparation method thereof | |
| CN1248697C (en) | Medicinal composition for treating chronic enteritis and its preparing process | |
| CN104800675A (en) | Medicament for treating active ulcerative colitis | |
| CN103585580A (en) | Chinese medicinal preparation for treating recurrent oral ulceration | |
| CN100389676C (en) | Health-care food and its soft capsule for improving immunity of anti alimentary canal infection, and its prepn. method | |
| CN103301309B (en) | Traditional Chinese herbal medicine for treating laryngocarcinoma and esophagus cancer | |
| CN100509003C (en) | Medicament of treating psoriasis | |
| CN105396107A (en) | Traditional Chinese medicine composition for curing gastroenteritis | |
| CN105265786A (en) | Compound feed for cows and preparation method thereof | |
| CN104225343A (en) | Chinese herbal preparation for treating urinary tract infection and preparation method thereof | |
| CN104800698A (en) | Traditional Chinese medicine composition for treating inflammations and cysts | |
| CN102327496A (en) | Traditional Chinese medicine preparation for treating and preventing cancer | |
| CN103585471A (en) | Traditional Chinese medicine composition for treating thrombocytopenia | |
| CN113827694A (en) | Traditional Chinese medicine for treating haemorrhoids and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: He Wenqian Document name: Written notice of preliminary examination of application for patent for invention |
|
| C06 | Publication | ||
| PB01 | Publication | ||
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: He Wenqian Document name: Notification of Publication of the Application for Invention |
|
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: He Wenqian Document name: Notification of Passing Examination on Formalities |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |