CN102302589A - Chinese medicinal composition for treating diarrhea irritable bowel syndrome and preparation method thereof - Google Patents

Chinese medicinal composition for treating diarrhea irritable bowel syndrome and preparation method thereof Download PDF

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Publication number
CN102302589A
CN102302589A CN201110231212A CN201110231212A CN102302589A CN 102302589 A CN102302589 A CN 102302589A CN 201110231212 A CN201110231212 A CN 201110231212A CN 201110231212 A CN201110231212 A CN 201110231212A CN 102302589 A CN102302589 A CN 102302589A
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percent
fructus
chinese medicinal
medicinal composition
windproof
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陈丽英
李青
寇学良
彭全民
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Abstract

The invention discloses a Chinese medicinal composition for treating diarrhea irritable bowel syndrome. The Chinese medicinal composition consists of the following raw materials in percentage by mass: 25 to 29 percent of white peony root, 11 to 15 percent of bighead atractylodes rhizome, 7 to 11 percent of dried tangerine peel, 3 to 7 percent of divaricate saposhnikovia root, 12 to 16 percent of spinach fruit, 12 to 16 percent of smoked plum, 12 to 16 percent of pomegranate peel, and 2 to 6 percent of liquorice, wherein the sum of the mass percents of the raw materials is 100%. The invention also discloses a preparation method of the Chinese medicinal composition, the preparation method comprises weighing and mixing the white peony root, the bighead atractylodes rhizome, the dried tangerine peel, the divaricate saposhnikovia root, the spinach fruit, the smoked plum, the pomegranate peel and the liquorice. The Chinese medicinal composition has good treatment effect, no toxic or side effect and no recurrence.

Description

A kind of Chinese medicine composition of treating the diarrhea type irritable bowel syndrome and preparation method thereof
Technical field
The invention belongs to technical field of Chinese medicines, relate to a kind of Chinese medicine composition of treating the diarrhea type irritable bowel syndrome, the invention still further relates to the method for preparing of this Chinese medicine composition.
Background technology
Irritable bowel syndrome (IBS) is modal functional gastrointestinal disorder property disease; Be that abdominal discomfort or the stomachache relevant with defecation is one group of main clinical disease; Often change with the stool character unusual with bowl evacuation habit; Symptom duration exists or outbreak repeatedly; Be one of persistent ailment of serious harm human health, divide diarrhea-type, constipation type and mixed type according to clinical predominal symptom.IBS is a kind of global disease, and crowd's prevalence is higher.The sickness rate of China IBS is on the rise in recent years, and its overall prevalence is many between 5%-25%, and conservative estimation China has 300,000,000 IBS patients approximately.Because IBS also is in conceptual phase in China; The problem that exists in diagnosis and the treatment is still many; The western medical treatment primary disease is had difficulty in taking a step at present; Therefore the research of pathogenic factor, mechanism and the therapy measure of IBS is a difficult problem of whole world gastrointestinal disease research field, also is the opportunity of performance Chinese medicine advantage.
At present, for the treatment of diarrhea-type IBS, modern medicine is taked Therapeutic Method such as the single mediator receptor of spasmolytic, antidiarrheal symptomatic treatment and agonist antagonism, antidepressant, though there is the certain curative effect side effect obvious, relapse rate is high.IBS has onset and hides, shows effect repeatedly, delays the difficult characteristics that heal.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition of treating the diarrhea type irritable bowel syndrome, therapeutic effect is good, has no side effect, and does not recur.
Another object of the present invention provides the method for preparing of the Chinese medicine composition of above-mentioned treatment diarrhea type irritable bowel syndrome.
The technical scheme that the present invention adopted is, a kind of Chinese medicine composition of treating the diarrhea type irritable bowel syndrome is made up of following raw material by mass percentage:
Radix Paeoniae Alba 25%-29%, Rhizoma Atractylodis Macrocephalae 11%-15%, Pericarpium Citri Reticulatae 7%-11%, windproof 3%-7%, Fructus spinaciae 12%-16%, Fructus Mume 12%-16%, Pericarpium Granati 12%-16%, Radix Glycyrrhizae 2%-6%, the mass percent summation of above component is 100%.
Another technical scheme that the present invention adopted is, the method for preparing of the Chinese medicine composition of above-mentioned treatment diarrhea type irritable bowel syndrome is carried out according to the following steps:
According to mass percent; Take by weighing windproof, the Fructus spinaciae of 12%-16% of Pericarpium Citri Reticulatae, the 3%-7% of the Rhizoma Atractylodis Macrocephalae, the 7%-11% of the Radix Paeoniae Alba, the 11%-15% of 25%-29%, the Fructus Mume of 12%-16%, the Pericarpium Granati of 12%-16%, the Radix Glycyrrhizae of 2%-6% respectively, the mass percent summation of above component is 100%; Then the Radix Paeoniae Alba that takes by weighing, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, windproof, Fructus spinaciae, Fructus Mume, Pericarpium Granati, Radix Glycyrrhizae are mixed and promptly get.
The Chinese medicine composition of treatment diarrhea type irritable bowel syndrome of the present invention, simple and practical, good effect, instant effect, reasonable recipe.Not only having prevented has loose bowels but also drive away stagnates evilly, reaches that the flat spleen of liver is strong, heresy is gone to rush down the effect of ending, and had following characteristics:
(1) the present invention has characteristic and the innovation of system on the fong theory, and it restrains spleen according to liver-yang hyperactivity, and dysfunction of the spleen in transportation, intestinal lose astringency inducing and internal organs gas not freely and the syndrome characteristic of depositing and found method of treatment, and prescription medicine forms.Chinese traditional treatment IBS is many with the report of tongxieyao formula eliminating pathogen in the liver spleen invigorating; But primary disease often has stomachache in clinical occurs with diarrhoea simultaneously; Diarrhea and defecation freely do not exist simultaneously; The present invention causes abdominal pain diarrhea, internal organs gas not to fall having influence on the not smooth pathogenic characteristic of defecation according to liver-yang hyperactivity is insufficiency of the spleen; In the eliminating pathogen in the liver spleen invigorating, catch and take the photograph solid intestinal and vertical evil intestinal stasis relieving and usefulness, the theoretic innovation of method of treatment is arranged.
(2) innovation on the prescription is arranged, it is that monarch drug eliminating pathogen in the liver easing the affected liver, the inferior Rhizoma Atractylodis Macrocephalae that uses are ministerial drug spleen invigorating activating the spleen that the Radix Paeoniae Alba is reused by full side; Light evilly logically fall and catch and take the photograph solid intestinal, fall, indulge to lead to and fall and catch and astringency inducing and the act used and use Fructus Mume, the Pericarpium Granati of Fructus spinaciae and windproof and astringing to arrest diarrhea to share in the prescription first to reach to have to rise to have with Fructus spinaciae, windproof, Pericarpium Citri Reticulatae, Pericarpium Granati, Fructus Mume are vertical.In many ways take into account, make a distinction between the important and the lesser one, go up and down and usefulness, not only having prevented has loose bowels but also drives away stagnates evilly, reaches that the flat spleen of liver is strong, heresy goes to rush down effect only.And Fructus spinaciae, Pericarpium Granati, Fructus Mume are two medications of doctor's food, can be used as to transfer and mend, and the obvious bias medicine of Fang Zhongwu, full presciption medicine property is gentle.
(3) it is effective that the advantage on the curative effect shows as various parameters for observation on effect improvement, and late result is good, and required expense is low, and is economical and practical, no obvious toxic-side effects of safety and untoward reaction.
(4) this research is distinguished the disease of effecting a permanent cure for the traditional Chinese medical science provides a new dialectical thinking and has executed the improvement thought, and the clinical data of a uniqueness also is provided for similar research, and the further investigation that promotes similar science is had the effect of actively promoting.
(5) conservative estimation China has 300,000,000 irritable bowel syndrome patients approximately, and this side of controlling has the treatment required time short, no poisonous side effect of medicine, and late result is good, improves the quality of living.Required expense is low, can accomplish treatment in outpatient service, and the inspection means are simple; Do not need the characteristics of specific condition and equipment, economical and practical, be fit to community, rural area and most of wage-earners, low-income household's use; Can alleviate the payment for medical care input of family and country, social benefit is huge.
The specific embodiment
Below in conjunction with the practical implementation example the present invention is elaborated.
The Chinese medicine composition of treatment diarrhea type irritable bowel syndrome of the present invention, form by following raw material by mass percentage:
Radix Paeoniae Alba 25%-29%, Rhizoma Atractylodis Macrocephalae 11%-15%, Pericarpium Citri Reticulatae 7%-11%, windproof 3%-7%, Fructus spinaciae 12%-16%, Fructus Mume 12%-16%, Pericarpium Granati 12%-16%, Radix Glycyrrhizae 2%-6%, the quality summation of above component is 100%.
Effect and the function of each raw material in this medicine cures mainly:
Reusing the Radix Paeoniae Alba is monarch drug, Radix Paeoniae Alba bitter in the mouth, acid, and cold nature is returned the liver spleen channel, the ability easing the affected liver to relieve pain, suppressing liver-YANG is the eliminating pathogen in the liver suppressing the hyperactive liver, the key medicine of harmonizing liver-spleen, Compendium of Material Medica is said: " the Radix Paeoniae Alba strengthening the spleen can rush down wood in soil.”
The Rhizoma Atractylodis Macrocephalae is a ministerial drug, and Rhizoma Atractylodis Macrocephalae property bitter but sweet flavor temperature is returned the taste warp, has the spleen invigorating QI invigorating, and the effect of dampness diuretic helps the Radix Paeoniae Alba to become the eliminating pathogen in the liver spleen invigorating altogether, harmonizing liver-spleen, the effect of relieving spasm to stop pain." book on Chinese herbal medicine converges and says " said: " insufficiency of the spleen strong, art can be mended it, and insufficiency of stomach is not received, and art can help it.”
The use of the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba is different with the use of monarch-minister drug in " having loose bowels " traditional treatment among this side; The colleague of medical circles thinks that to relating to the dependency between the liver spleen in the diarrhea-type IBS pathogenesis irritability is violated spleen in an opponent's defence owing to deficient earth being subjugated by wood more.Proposing the treatment rule has subduing the hyperfunction of the liver to hold up spleen, transfers liver fortune (being good for) spleen, soothing liver and strengthening spleen, spleen invigorating to transfer liver etc.; All inherit tongxieyao formula in the overwhelming majority prescription, all relating to, used the Radix Paeoniae Alba and the Rhizoma Atractylodis Macrocephalae, all is to be monarch drug with Rhizoma Atractylodis Macrocephalae spleen invigorating; Consumption is greater than the Radix Paeoniae Alba, and Radix Paeoniae Alba easing the affected liver is a ministerial drug.Also have the part viewpoint to think to be worried angry, strongly fragrant impairing the liver of a specified duration, transverse invasion of hyperactive liver-QI is violated spleen, temper is gradually hindered, and forms that liver-yang hyperactivity is insufficiency of the spleen and sore rushes down.This is consistent with modern medicine to primary disease etiology and pathogenesis research conclusion, and the various pathomechanism theories of modern medicine all relate to spiritual psychological factor to the disorderly influence of function of intestinal canal.The present invention combines the principle of modern medicine to diarrhea-type IBS pathology and Study on Pathogenesis and differentiation of tcm, thinks that the pathogenesis of diarrhea-type IBS is that liver-yang hyperactivity is insufficiency of the spleen, and edema with the liver involved is taken advantage of spleen, causes dysfunction of the spleen in transportation, spleen-QI failing to rise up and having loose bowels.Think that defecation is arranged again is not smooth when having loose bowels, and to be spleen suffer from a deficiency of the kidney that intestinal is solid to rush down for this, pathogen is stopped up and is stagnated, and internal organs gas does not fall and stagnates, if the antidiarrheal astringing intestine to stop diarrhea just stagnates more very, controlling the purging FU-organs that stagnates increases the weight of to have loose bowels, and the good plan of executing is only with the vertical method of catching, and astringing intestine to stop diarrhea and intestinal stasis relieving be usefulness also.The rule of treatment should be kept eliminating pathogen in the liver spleen invigorating, harmonizing liver-spleen, vertically caught that a surname takes the photograph, the rule of treatment of intestine-stabling and anti-diarrheal, and reusing the Radix Paeoniae Alba is monarch drug, and the Rhizoma Atractylodis Macrocephalae is a ministerial drug.
Pericarpium Citri Reticulatae, windproof, Fructus spinaciae, Fructus Mume, Pericarpium Granati are adjuvant drug altogether, and Fructus spinaciae is indulged evil intestinal stasis relieving, intestine moistening is led off, close windproof Fructus Mume, Pericarpium Granati treatment diarrhea-type IBS with astringing to arrest diarrhea reach have rise have fall, vertical and logically fall and catch and astringency inducing and the act used.Fructus spinaciae, record in " the southern regions of the Yunnan Province book on Chinese herbal medicine ", another name Herba Chenopodii Aristati colza, Fructus Tribuli, it is warm in nature, sharp the intestines and stomach, dispelling pathogenic wind for improving eyesight, sharp lung intestine moistening; Though with Fructus Tribuli in " herbal classic " character and micro-aspect have any different, its drug effect is similar, belongs to similar medicine; Have loose bowels with windproof be intended to loose irritability and the gas lift of agitating the clear sun of taste, the clear sun of nationality rises then paddy and refines, and paddy is refined, and then paddy is turbid unlikely dirty, and diarrhoea can be ended.Successive dynasties document record is windproof uses the effect that reaches dispelling wind heresy, reason lung qi, intestine moistening road with the Fructus Tribuli compatibility, so windproof and Fructus spinaciae share with square in the antidiarrheal rule of treatment cooperate and reach antidiarrheal and do not stay the bandit to close heresy, the delicate effect that purging FU-organs intestine moistening and not increasing the weight of is had loose bowels.And Fructus spinaciae, Pericarpium Granati, Fructus Mume are two medications of doctor's food, can be used as to transfer and mend, and the Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, the obvious bias medicine of Fang Zhongwu, full presciption medicine property is gentle, and life-time service does not have obvious toxic-side effects yet.
Radix Glycyrrhizae can invigorating the spleen and benefiting QI, to help the monarch and his subjects, and again can coordinating the actions of various ingredients in a prescription and for making.
More than embodied a concentrated reflection of unusual theory innovation and the Shi Zhi innovation of the present invention, this also is the technological difficulties and creative place of this invention.
Function cures mainly: the treatment irritable bowel syndrome, eliminating pathogen in the liver spleen invigorating, harmonizing liver-spleen, catch and take the photograph antidiarrheal, vertical evil intestinal stasis relieving.
Usage and dosage: take by weighing Chinese medicine composition 111g of the present invention, and with the card plus-minus, mix the pot that is used as medicine, cold water steeps slowly; Add water and do not have powder 3-5cm, soaked 20-30 minute, add a cover; Boil rapidly with high heat, use slow fire instead and keep about 10-15 minute and get final product, this dose can be fried in shallow oil 2-3 time.Altogether extracting juice mixes about 400-500ml, every day potion, morning and evening twice sub-service.4 weeks were 1 course of treatment.
The present invention treats the method for preparing of the Chinese medicine composition of diarrhea type irritable bowel syndrome, carries out according to the following steps:
According to mass percent; Take by weighing windproof, the Fructus spinaciae of 12%-16% of Pericarpium Citri Reticulatae, the 3%-7% of the Rhizoma Atractylodis Macrocephalae, the 7%-11% of the Radix Paeoniae Alba, the 11%-15% of 25%-29%, the Fructus Mume of 12%-16%, the Pericarpium Granati of 12%-16%, the Radix Glycyrrhizae of 2%-6% respectively, the quality summation of above component is 100%; Then the Radix Paeoniae Alba that takes by weighing, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, windproof, Fructus spinaciae, Fructus Mume, Pericarpium Granati, Radix Glycyrrhizae are mixed and promptly get.
Pharmacodynamic experiment:
(1) irritability diarrhoea is had regulating action preferably:
Preparation of the present invention irritates stomach for the model mice of stress suffering from diarrhoea, and can obviously reduce the diarrhoea number of times, loose stool rate, loose stool level and the diarrhoea index that stress mice Folium Sennae diarrhea inducing cause, illustrates that preparation of the present invention has obvious antagonism to diarrhoea.
(2) enhancing has inhibitory action to the irritability intestinal peristalsis promoting:
Preparation of the present invention irritates stomach for the model mice of stress suffering from diarrhoea, and can suppress the fltting speed of hyperfunction small intestinal due to normal small intestinal and the neostigmine, shortening prepared Chinese ink advance distance, and the intestinal length that slows down is apart from peristaltic velocity and degree.
(3) analgesia, sedation:
What preparation of the present invention can reduce obviously that 0.6% acetic acid causes the pain mice turns round the body number of times, and the body of turning round that prolongs mice takes place by incubation period; Improve the pain threshold that thermal source causes the pain mice; Can reduce the two forelimbs of normal mouse and praise the number of times of spontaneous activity.Illustrate that preparation of the present invention has significant analgesia role to mice because of the pain reaction that hot pain and chemical stimulation cause, and longer duration; The mobility of normal white mice is obviously reduced, have certain sedation.
(4) have the effect of the gastrointestinal of adjusting compliance:
Preparation of the present invention can obviously increase food-intake, body weight, thereby promotes the absorption of nutrient substance; Improve digestive function, the defecation time that shortening stress mice, the not smooth possibility of defecation that solution stress mice exists.
(5) antifatigue effect:
Preparation of the present invention can prolong mice low temperature swimming time.Illustrate that we have the mice of raising muscle power, health invigorating, have certain antifatigue effect, enhancing immunity.
No any toxicity medicine composition in the Chinese medicine composition among the present invention does not have the prescription of violation compatibility taboo yet.
Clinical observation
128 routine patients are divided into two groups immediately, and the treatment group is treated the decoct of the Chinese medicine composition of diarrhea type irritable bowel syndrome with the present invention; Matched group is an amount of with imodium, oryzanol.It was 1 course of treatment all with 4 weeks.The result shows that treatment group effective percentage 92.18%, matched group effective percentage compare for 64.06%, two group, have significant difference.Two groups all in various degree improvement the clinical symptoms of diarrhea-type IBS; Diarrheal is treated; Though treatment group and matched group be there was no significant difference in the improvement of times of defecation; But the treatment group is better than matched group in improving stool character (loose stool), significant difference is also arranged in elimination stomachache, abdominal distention, defecation aspect poverty-stricken.
Embodiment 1
According to mass percent; Take by weighing 25% the Radix Paeoniae Alba, 11% the Rhizoma Atractylodis Macrocephalae, 7% Pericarpium Citri Reticulatae, 3% windproof, 16% Fructus spinaciae, 16% Fructus Mume, 16% Pericarpium Granati, 6% Radix Glycyrrhizae respectively, then the Radix Paeoniae Alba that takes by weighing, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, windproof, Fructus spinaciae (decocting a drug wrapped), Fructus Mume, Pericarpium Granati, Radix Glycyrrhizae are mixed to decoct promptly getting.
Embodiment 2
According to mass percent; Take by weighing 29% the Radix Paeoniae Alba, 15% the Rhizoma Atractylodis Macrocephalae, 11% Pericarpium Citri Reticulatae, 7% windproof, 12% Fructus spinaciae, 12% Fructus Mume, 12% Pericarpium Granati, 2% Radix Glycyrrhizae respectively, then the Radix Paeoniae Alba that takes by weighing, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, windproof, Fructus spinaciae, Fructus Mume, Pericarpium Granati, Radix Glycyrrhizae are mixed to pulverize promptly getting.
Embodiment 3
According to mass percent; Take by weighing 27% the Radix Paeoniae Alba, 13% the Rhizoma Atractylodis Macrocephalae, 9% Pericarpium Citri Reticulatae, 5% windproof, 14% Fructus spinaciae, 14% Fructus Mume, 14% Pericarpium Granati, 4% Radix Glycyrrhizae respectively, the Radix Paeoniae Alba that takes by weighing, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, windproof, Fructus spinaciae, Fructus Mume, Pericarpium Granati, Radix Glycyrrhizae are mixed promptly getting then.

Claims (2)

1. Chinese medicine composition of treating the diarrhea type irritable bowel syndrome, form by following raw material by mass percentage:
Radix Paeoniae Alba 25%-29%, Rhizoma Atractylodis Macrocephalae 11%-15%, Pericarpium Citri Reticulatae 7%-11%, windproof 3%-7%, Fructus spinaciae 12%-16%, Fructus Mume 12%-16%, Pericarpium Granati 12%-16%, Radix Glycyrrhizae 2%-6%, the mass percent summation of above component is 100%.
2. the method for preparing of the said syndrome Chinese medicine composition of claim 1, specifically carry out according to following steps:
According to mass percent; Take by weighing windproof, the Fructus spinaciae of 12%-16% of Pericarpium Citri Reticulatae, the 3%-7% of the Rhizoma Atractylodis Macrocephalae, the 7%-11% of the Radix Paeoniae Alba, the 11%-15% of 25%-29%, the Fructus Mume of 12%-16%, the Pericarpium Granati of 12%-16%, the Radix Glycyrrhizae of 2%-6% respectively, the mass percent summation of above component is 100%; Then the Radix Paeoniae Alba that takes by weighing, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, windproof, Fructus spinaciae, Fructus Mume, Pericarpium Granati, Radix Glycyrrhizae are mixed and promptly get.
CN201110231212A 2011-08-12 2011-08-12 Chinese medicinal composition for treating diarrhea irritable bowel syndrome and preparation method thereof Pending CN102302589A (en)

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Cited By (2)

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CN104958409A (en) * 2015-07-13 2015-10-07 青岛云天生物技术有限公司 Traditional Chinese medicine preparation for treating infantile spleen deficiency type diarrhea and preparation method thereof
CN105031604A (en) * 2015-09-19 2015-11-11 庞群 Irritable bowel syndrome and treating medicine thereof

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Publication number Priority date Publication date Assignee Title
CN104958409A (en) * 2015-07-13 2015-10-07 青岛云天生物技术有限公司 Traditional Chinese medicine preparation for treating infantile spleen deficiency type diarrhea and preparation method thereof
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Application publication date: 20120104