CN1331528C - Medicine for treating epilepsy clonus, child convulsion, prosopospasm and its preparation method - Google Patents
Medicine for treating epilepsy clonus, child convulsion, prosopospasm and its preparation method Download PDFInfo
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- CN1331528C CN1331528C CNB2005100963518A CN200510096351A CN1331528C CN 1331528 C CN1331528 C CN 1331528C CN B2005100963518 A CNB2005100963518 A CN B2005100963518A CN 200510096351 A CN200510096351 A CN 200510096351A CN 1331528 C CN1331528 C CN 1331528C
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Abstract
The present invention relates to a medicine for treating epilepsy, convulsion, child fright wind and facial spasm, which is prepared from milkvetch root, pilose asiabell root, red sage root, bupleurum root, spine date seed, thinleaf milkwort root, tall gastrodis tuber, uncaria, grassleaf sweetflag rhizome, bile arisaema, angelica, stiff silkorm, medicated leaven, curcuma root, liquorice, giant typhonium rhizome (prepared), etc. The present invention has the efficacy of eliminating phlegm for resuscitation, tranquilizing the spirit, relieving convulsion, expelling wind and relieving spasm. The medicine of the present invention has the advantages of no toxic or side effect and obvious clinical observation treatment effect on treating epilepsy, convulsion, child fright wind and facial spasm.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of epilepsy clonus, infantile convulsion, facial spasm and preparation method thereof.
Background technology
No matter epilepsy is constitutional or Secondary cases, all can cause neuron infringement, the hypophrenia, wound even suddenly unexpected death etc.Treating most important purpose is control of seizures, keep the normal of neural moral function, and the main means of control of seizures is Drug therapy.There is patient clear and definite focus, that Drug therapy is invalid or the toxic and side effects that generation can't tolerate need consider operative treatment.
Infantile convulsion is the concurrent emergency case in multiple lysis of children's.Modern medicine is generally treated respectively by stage of attack and catabasis., there is the respiratory passage unblocked of maintenance stage of attack for wanting with spasmolytic; Catabasis is based on treatment protopathy.General infantile convulsion outbreak needs hospital treatment, and is safer.Alleviating convalescent period, remove treatment protopathy sunset and foretell, mainly is diet care.Therefore, dietetic therapy also is only applicable to alleviate convalescent period, and health invigorating is arranged, and fast track rehabilitation reduces the effect of showing effect.
Facial spasm (claiming hemifacial spasm, facial spasm again) is that the involuntary painless property paroxysmal of a side surface part muscle is twitched.When excited (as glad, anger, the unacquainted people of interview etc.), it is frequent all the more, serious to twitch.The course of disease is long, severe symptom can make palpebral fissure diminish, and thing, reading are looked in influence; Because frequent face spasm causes patient's facial hemiparalysis, is reluctant to contact with the people, influence patient's social and work, patient's thought is constrained also very big.Facial spasm and primary trigeminal neuralgia are more common in a side and old people, though multiple therapy methods is arranged, comprise operative treatment, but advance the cranium operation and have complication, disorders post surgery recurrence, function of nervous system's forfeiture equivalent risk, therapy of combining Chinese and Western medicine neither destroys function of nervous system, can avoid operation risk again, and painless, noinvasive, especially be fit to inoperable gerontal patient.
Summary of the invention
The purpose of this invention is to provide a kind of medicine for the treatment of epilepsy clonus, infantile convulsion, facial spasm and preparation method thereof, be used for epilepsy clonus, infantile convulsion, facial spasm due to the wind-phlegm impatency, short treating period, cure rate height, without any side effects.
Solution of the present invention is based on motherland's medical science to treatment epilepsy clonus, infantile convulsion, the pathogenetic understanding of facial spasm and Therapeutic Principle, with reference to the modern pharmacological research achievement, by traditional Chinese medical science prescription theory, skims the cream off milk.Its performance is eliminated phlegm for resuscitation, the arresting convulsion of calming the nerves, the effect of relieving spasm by calming endogenous wind.
Medicine of the present invention comprises the crude drug of following component: (consumption is a weight portion)
5～20 parts of 5～20 parts of Bombyx Batryticatus of 5～20 parts of Ramulus Uncariae Cum Uncis of Rhizoma Gastrodiae
10～30 parts of 10～30 parts of Radix Salviae Miltiorrhizaes of 10～30 parts of Radix Codonopsis of the Radix Astragali
3～15 parts of 5～20 parts of Radix Polygalaes of 3～15 parts of Semen Ziziphi Spinosaes of Radix Bupleuri
10～30 parts of 3～15 parts of Radix Angelicae Sinensis of 3～15 parts of Arisaema Cum Bile of Rhizoma Acori Graminei
1～6 part of Radix Curcumae 3～1 5 part Rhizoma Typhonii (processed).
In above-mentioned raw materials, also can add 0.2～2 part of 3～15 parts of Massa Medicata Fermentatas and/or 3～15 parts in Radix Glycyrrhizae and/or Borneolum Syntheticum.
Optimum weight part proportioning of medicine of the present invention is:
14 parts of 10.5 parts of Radixs Astragali of 10.5 parts of Bombyx Batryticatus of 10.5 parts of Ramulus Uncariae Cum Uncis of Rhizoma Gastrodiae
10.5 parts of 7 parts of Semen Ziziphi Spinosaes of 14 parts of Radix Bupleuri of 14 parts of Radix Salviae Miltiorrhizaes of Radix Codonopsis
14 parts of 7 parts of Radix Angelicae Sinensis of 7 parts of Arisaema Cum Bile of 7 parts of Rhizoma Acori Graminei of Radix Polygalae
3.5 parts of 7 parts of Rhizoma Typhonii (processed) of Radix Curcumae.
In above-mentioned raw materials, also can add 0.6 part of 7 parts of Massa Medicata Fermentatas and/or 7 parts in Radix Glycyrrhizae and/or Borneolum Syntheticum.
Above-mentioned each component is made medicine production method of the present invention is: Bombyx Batryticatus and/or Massa Medicata Fermentata and/or Borneolum Syntheticum powder are broken into fine powder, and be standby; The Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Bupleuri, Semen Ziziphi Spinosae, Radix Polygalae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Rhizoma Acori Graminei, Arisaema Cum Bile, Radix Angelicae Sinensis, Radix Curcumae and/or Radix Glycyrrhizae, Rhizoma Typhonii (processed) decoct with water three times, adding for the first time 8～12 times of water gagings decocted 1～3 hour, adding for the second time 6～10 times of water gagings decocted 1～3 hour, adding 4～10 times of water gagings for the third time decocted 0.5～2 hour, merge three times decocting liquid, filter, filtrate decompression is condensed into relative density and is determined as 1.20～1.38 thick paste at 60 ℃, and is standby; Standby thick paste is carried in water intaking, adds standby fine powder, and with facing-up method mix homogeneously, vacuum drying is ground into fine powder, makes soft material in right amount with 80% ethanol, granulates, and drying is made capsule.
Rhizoma Typhonii (processed) wherein: get clean Rhizoma Typhonii, separately size is soaked, and changes water every day 2～3 times, after a few days as play a glutinous foam, adds Alumen (every 100kg Rhizoma Typhonii use Alumen 2kg) after changing water, steep and changes water again after 1 day, to mouthful tasting little numb feeling in the tongue degree of being that has, taking-up.Ginger slice, Alumen powder put add suitable quantity of water in the pot, after boiling, pour Rhizoma Typhonii into and boil altogether, pull out, remove ginger slice, dry in the air to 6 seventy percent and do, cut sheet, drying to the no white heart.(see " one one the 80th page of Chinese pharmacopoeia version in 2000)
Get Rhizoma Gastrodiae among the we, sweet, flat, return Liver Channel, endogenous wind stopping relieving convulsion, suppressing the hyperactive liver and subsiding YANG; Ramulus Uncariae Cum Uncis, sweet, be slightly cold, return liver, pericardium channel, endogenous wind stopping relieving convulsion, heat clearing away suppressing the hyperactive liver; Bombyx Batryticatus, salty, hot, flat, return Liver Channel, endogenous wind stopping relieving convulsion, wind-expelling pain-stopping; With the Radix Astragali, sweet, tepor is returned spleen channel again, tonifying Qi and lifting yang, and benefit is defended consolidating superficial resistance; Radix Codonopsis, sweet, flat, return spleen channel, invigorating the spleen and replenishing QI is promoted the production of body fluid and is nourished blood; Radix Salviae Miltiorrhizae, hardship is slightly cold, GUIXIN, pericardium, Liver Channel, blood circulation promoting and blood stasis dispelling, nourishing blood to tranquillize the mind; Radix Angelicae Sinensis, sweet, hot, warm, return liver, the heart, spleen channel, enrich blood, invigorate blood circulation; Above-mentioned seven medicines cooperate reaching the merit of strengthening vital QI to eliminate pathogenic factors, suppressing the hyperactive liver and subsiding YANG, and the endogenous wind stopping relieving convulsion can benefiting QI for activating blood circulation when eliminating phlegm for resuscitation, and meets the pathogenic characteristic of primary disease, is we's monarch drug altogether; Rhizoma Acori Graminei, suffering, temperature, GUIXIN warp, resuscitation inducing and mind tranquilizing, removing dampness to restore normal function of the stomach; Rhizoma Typhonii (processed), hot, sweet, return spleen, stomach warp, drying dampness to eliminate phlegm is expellingged wind and relieving convulsion; Arisaema Cum Bile, bitter, hot, temperature is returned lung, liver, spleen channel, removing heat-phlegm, dispelling wind and relieving convulsion; Semen Ziziphi Spinosae, Radix Polygalae tranquilizing by nourishing the heart; Above-mentioned five medicines are strengthened the function of monarch drug, are ministerial drug; Radix Bupleuri, bitter, hot, be slightly cold GUIXIN envelope warp, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy; Radix Curcumae, hot, bitter, cold, GUIXIN, liver, gallbladder meridian, promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, removing heat from blood clears away heart-fire; Massa Medicata Fermentata, sweet, hot, warm, return spleen, stomach warp, stomach function regulating reduces phlegm; Borneolum Syntheticum, hot, bitter, be slightly cold GUIXIN warp, the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain; Be we's adjuvant drug altogether; Radix Glycyrrhizae, sweet, flat, GUIXIN, lung, spleen, stomach warp, invigorating the spleen and replenishing QI, relieving spasm to stop pain relaxes the property of medicine, is we's messenger drug.
Advantage of the present invention is:
Along with the raising day by day of modernization of Chinese medicine degree, on the basis of herbal pharmacology and fitochemical studies, increasing middle pharmaceutically active ingredient or effective site are proved to be definite curative effect, prescription compatibility of medicines of the present invention is reasonable, technology advanced person, scientific and technical content height is modern herbal species.
For showing the control effect of medicine of the present invention to infantile spasm and various epilepsy, the present invention is through the clinical observation of 64 routine systems, male 34 people, and women 30 people all meet inclusion criteria, do not have and withdraw from and reject case.10 years old～67 years old its age.All case all meets the type of wind-phlegm blocking standard.
Instructions of taking: 5 of medicines of the present invention a time, 3 times on the one, treatment time is January.
Therapeutic outcome: in 64 routine patients, produce effects 32 examples, effective 24 examples, invalid 8 examples, total effective rate 87.5%.
In the clinical use of patient, do not find any toxicity, liver, kidney merit do not have change before and after the treatment.
In sum, medicine of the present invention has eliminates phlegm for resuscitation, the arresting convulsion of calming the nerves, and the effect of relieving spasm by calming endogenous wind has stable, calm, syngignoscism, and total effective rate is 87.5%, is worth clinical expansion to use.
Specific embodiment
Embodiment 1
By following weight weighting raw materials (unit: gram)
Rhizoma Gastrodiae 10.5, Ramulus Uncariae Cum Uncis 10.5, Bombyx Batryticatus 10.5, the Radix Astragali 14, Radix Codonopsis 14, Radix Salviae Miltiorrhizae 14, Radix Bupleuri 7, Semen Ziziphi Spinosae 10.5, Radix Polygalae 7, Rhizoma Acori Graminei 7, Arisaema Cum Bile 7, Radix Angelicae Sinensis 14, Radix Curcumae 7, Rhizoma Typhonii (processed) 3.5.
Preparation method: take by weighing the above-mentioned raw materials medicine, Bombyx Batryticatus is ground into fine powder, standby; The Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Bupleuri, Semen Ziziphi Spinosae, Radix Polygalae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Rhizoma Acori Graminei, Arisaema Cum Bile, Radix Angelicae Sinensis, Radix Curcumae, Rhizoma Typhonii (processed) decoct with water three times, adding for the first time 8～12 times of water gagings decocted 1～3 hour, adding for the second time 6～10 times of water gagings decocted 1～3 hour, adding 4～10 times of water gagings for the third time decocted 0.5～2 hour, merge three times decocting liquid, filter, filtrate decompression is condensed into relative density and is determined as 1.20～1.38 thick paste at 60 ℃, and is standby; Standby thick paste is carried in water intaking, adds standby fine powder, and with facing-up method mix homogeneously, vacuum drying is ground into fine powder, makes soft material in right amount with 80% ethanol, granulates, and drying is made capsule.
Embodiment 2
By following weight weighting raw materials (unit: gram)
Rhizoma Gastrodiae 5, Ramulus Uncariae Cum Uncis 5, Bombyx Batryticatus 5, the Radix Astragali 10, Radix Codonopsis 10, Radix Salviae Miltiorrhizae 10, Radix Bupleuri 3, Semen Ziziphi Spinosae 5, Radix Polygalae 3, Rhizoma Acori Graminei 3, Arisaema Cum Bile 3, Radix Angelicae Sinensis 10, Radix Curcumae 3, Rhizoma Typhonii (processed) 1.
Preparation method: take by weighing the above-mentioned raw materials medicine, Bombyx Batryticatus is ground into fine powder, standby; The Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Bupleuri, Semen Ziziphi Spinosae, Radix Polygalae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Rhizoma Acori Graminei, Arisaema Cum Bile, Radix Angelicae Sinensis, Radix Curcumae, Rhizoma Typhonii (processed) decoct with water three times, adding for the first time 8～12 times of water gagings decocted 1～3 hour, adding for the second time 6～10 times of water gagings decocted 1～3 hour, adding 4～10 times of water gagings for the third time decocted 0.5～2 hour, merge three times decocting liquid, filter, filtrate decompression is condensed into relative density and is determined as 1.20～1. 38 thick paste at 60 ℃, and is standby; Standby thick paste is carried in water intaking, adds standby fine powder, and with facing-up method mix homogeneously, vacuum drying is ground into fine powder, makes soft material in right amount with 80% ethanol, granulates, and drying is made capsule.
Embodiment 3
By following weight weighting raw materials (unit: gram)
Rhizoma Gastrodiae 20, Ramulus Uncariae Cum Uncis 20, Bombyx Batryticatus 20, the Radix Astragali 30, Radix Codonopsis 30, Radix Salviae Miltiorrhizae 30, Radix Bupleuri 15, Semen Ziziphi Spinosae 20, Radix Polygalae 15, Rhizoma Acori Graminei 15, Arisaema Cum Bile 15, Radix Angelicae Sinensis 30, Radix Curcumae 15, Rhizoma Typhonii (processed) 6.
Preparation method: take by weighing the above-mentioned raw materials medicine, Bombyx Batryticatus is ground into fine powder, standby; The Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Bupleuri, Semen Ziziphi Spinosae, Radix Polygalae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Rhizoma Acori Graminei, Arisaema Cum Bile, Radix Angelicae Sinensis, Radix Curcumae, Rhizoma Typhonii (processed) decoct with water three times, adding for the first time 8～12 times of water gagings decocted 1～3 hour, adding for the second time 6～10 times of water gagings decocted 1～3 hour, adding 4～10 times of water gagings for the third time decocted 0.5～2 hour, merge three times decocting liquid, filter, filtrate decompression is condensed into relative density and is determined as 1.20～1.38 thick paste at 60 ℃, and is standby; Standby thick paste is carried in water intaking, adds standby fine powder, and with facing-up method mix homogeneously, vacuum drying is ground into fine powder, makes soft material in right amount with 80% ethanol, granulates, and drying is made capsule.
Embodiment 4
By following weight weighting raw materials (unit: gram)
Rhizoma Gastrodiae 8, Ramulus Uncariae Cum Uncis 8, Bombyx Batryticatus 8, the Radix Astragali 13, Radix Codonopsis 12, Radix Salviae Miltiorrhizae 12, Radix Bupleuri 5, Semen Ziziphi Spinosae 7, Radix Polygalae 5, Rhizoma Acori Graminei 5, Arisaema Cum Bile 5, Radix Angelicae Sinensis 12, Radix Curcumae 5, Rhizoma Typhonii (processed) 2, Massa Medicata Fermentata 3.
Preparation method: take by weighing the above-mentioned raw materials medicine, Bombyx Batryticatus and Massa Medicata Fermentata are ground into fine powder, and be standby; The Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Bupleuri, Semen Ziziphi Spinosae, Radix Polygalae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Rhizoma Acori Graminei, Arisaema Cum Bile, Radix Angelicae Sinensis, Radix Curcumae, Rhizoma Typhonii (processed) decoct with water three times, adding for the first time 8～12 times of water gagings decocted 1～3 hour, adding for the second time 6～10 times of water gagings decocted 1～3 hour, adding 4～10 times of water gagings for the third time decocted 0.5～2 hour, merge three times decocting liquid, filter, filtrate decompression is condensed into relative density and is determined as 1.20～1.38 thick paste at 60 ℃, and is standby; Standby thick paste is carried in water intaking, adds standby fine powder, and with facing-up method mix homogeneously, vacuum drying is ground into fine powder, makes soft material in right amount with 80% ethanol, granulates, and drying is made capsule.
Embodiment 5
By following weight weighting raw materials (unit: gram)
Rhizoma Gastrodiae 12, Ramulus Uncariae Cum Uncis 12, Bombyx Batryticatus 12, the Radix Astragali 12, Radix Codonopsis 13, Radix Salviae Miltiorrhizae 13, Radix Bupleuri 8, Semen Ziziphi Spinosae 9, Radix Polygalae 8, Rhizoma Acori Graminei 8, Arisaema Cum Bile 8, Radix Angelicae Sinensis 12, Radix Curcumae 6, Rhizoma Typhonii (processed) 4, Radix Glycyrrhizae 15.
Preparation method: take by weighing the above-mentioned raw materials medicine, Bombyx Batryticatus is ground into fine powder, and is standby; The Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Bupleuri, Semen Ziziphi Spinosae, Radix Polygalae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Rhizoma Acori Graminei, Arisaema Cum Bile, Radix Angelicae Sinensis, Radix Curcumae, Radix Glycyrrhizae, Rhizoma Typhonii (processed) decoct with water three times, adding for the first time 8～12 times of water gagings decocted 1～3 hour, adding for the second time 6～10 times of water gagings decocted 1～3 hour, adding 4～10 times of water gagings for the third time decocted 0.5～2 hour, merge three times decocting liquid, filter, filtrate decompression is condensed into relative density and is determined as 1.20～1.38 thick paste at 60 ℃, and is standby; Standby thick paste is carried in water intaking, adds standby fine powder, and with facing-up method mix homogeneously, vacuum drying is ground into fine powder, makes soft material in right amount with 80% ethanol, granulates, and drying is made capsule.
Embodiment 6
By following weight weighting raw materials (unit: gram)
Rhizoma Gastrodiae 15, Ramulus Uncariae Cum Uncis 15, Bombyx Batryticatus 15, the Radix Astragali 18, Radix Codonopsis 18, Radix Salviae Miltiorrhizae 18, Radix Bupleuri 9, Semen Ziziphi Spinosae 9, Radix Polygalae 9, Rhizoma Acori Graminei 9, Arisaema Cum Bile 9, Radix Angelicae Sinensis 16, Radix Curcumae 4, Rhizoma Typhonii (processed) 4, Borneolum Syntheticum 2.
Preparation method: take by weighing the above-mentioned raw materials medicine, Bombyx Batryticatus and Borneolum Syntheticum powder are broken into fine powder, and be standby; The Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Bupleuri, Semen Ziziphi Spinosae, Radix Polygalae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Rhizoma Acori Graminei, Arisaema Cum Bile, Radix Angelicae Sinensis, Radix Curcumae, Rhizoma Typhonii (processed) decoct with water three times, adding for the first time 8～12 times of water gagings decocted 1～3 hour, adding for the second time 6～10 times of water gagings decocted 1～3 hour, adding 4～10 times of water gagings for the third time decocted 0.5～2 hour, merge three times decocting liquid, filter, filtrate decompression is condensed into relative density and is determined as 1.20～1.38 thick paste at 60 ℃, and is standby; Standby thick paste is carried in water intaking, adds standby fine powder, and with facing-up method mix homogeneously, vacuum drying is ground into fine powder, makes soft material in right amount with 80% ethanol, granulates, and drying is made capsule.
Embodiment 7
By following weight weighting raw materials (unit: gram)
Rhizoma Gastrodiae 7, Ramulus Uncariae Cum Uncis 7, Bombyx Batryticatus 7, the Radix Astragali 20, Radix Codonopsis 20, Radix Salviae Miltiorrhizae 20, Radix Bupleuri 10, Semen Ziziphi Spinosae 7, Radix Polygalae 10, Rhizoma Acori Graminei 10, Arisaema Cum Bile 10, Radix Angelicae Sinensis 20, Radix Curcumae 10, Rhizoma Typhonii (processed) 3, Massa Medicata Fermentata 15, Radix Glycyrrhizae 3.
Preparation method: take by weighing the above-mentioned raw materials medicine, Bombyx Batryticatus and Massa Medicata Fermentata are ground into fine powder, and be standby; The Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Bupleuri, Semen Ziziphi Spinosae, Radix Polygalae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Rhizoma Acori Graminei, Arisaema Cum Bile, Radix Angelicae Sinensis, Radix Curcumae, Radix Glycyrrhizae, Rhizoma Typhonii (processed) decoct with water three times, adding for the first time 8～12 times of water gagings decocted 1～3 hour, adding for the second time 6～10 times of water gagings decocted 1～3 hour, adding 4～10 times of water gagings for the third time decocted 0.5～2 hour, merge three times decocting liquid, filter, filtrate decompression is condensed into relative density and is determined as 1.20～1.38 thick paste at 60 ℃, and is standby; Standby thick paste is carried in water intaking, adds standby fine powder, and with facing-up method mix homogeneously, vacuum drying is ground into fine powder, makes soft material in right amount with 80%7 alcohol, granulates, and drying is made capsule.
Embodiment 8
By following weight weighting raw materials (unit: gram)
Rhizoma Gastrodiae 18, Ramulus Uncariae Cum Uncis 18, Bombyx Batryticatus 18, the Radix Astragali 25, Radix Codonopsis 25, Radix Salviae Miltiorrhizae 25, Radix Bupleuri 12, Semen Ziziphi Spinosae 18, Radix Polygalae 12, Rhizoma Acori Graminei 12, Arisaema Cum Bile 12, Radix Angelicae Sinensis 25, Radix Curcumae 12, Rhizoma Typhonii (processed) 2,10 parts of Massa Medicata Fermentatas, Borneolum Syntheticum 1.
Preparation method: take by weighing the above-mentioned raw materials medicine, Bombyx Batryticatus, Massa Medicata Fermentata and Borneolum Syntheticum powder are broken into fine powder, and be standby; The Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Bupleuri, Semen Ziziphi Spinosae, Radix Polygalae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Rhizoma Acori Graminei, Arisaema Cum Bile, Radix Angelicae Sinensis, Radix Curcumae, Rhizoma Typhonii (processed) decoct with water three times, adding for the first time 8～12 times of water gagings decocted 1～3 hour, adding for the second time 6～10 times of water gagings decocted 1～3 hour, adding 4～10 times of water gagings for the third time decocted 0.5～2 hour, merge three times decocting liquid, filter, filtrate decompression is condensed into relative density and is determined as 1.20～1.38 thick paste at 60 ℃, and is standby; Standby thick paste is carried in water intaking, adds standby fine powder, and with facing-up method mix homogeneously, vacuum drying is ground into fine powder, makes soft material in right amount with 80% ethanol, granulates, and drying is made capsule.
Embodiment 9
By following weight weighting raw materials (unit: gram)
Rhizoma Gastrodiae 9, Ramulus Uncariae Cum Uncis 9, Bombyx Batryticatus 9, the Radix Astragali 11, Radix Codonopsis 11, Radix Salviae Miltiorrhizae 11, Radix Bupleuri 8, Semen Ziziphi Spinosae 9, Radix Polygalae 11, Rhizoma Acori Graminei 11, Arisaema Cum Bile 13, Radix Angelicae Sinensis 18, Radix Curcumae 9, Rhizoma Typhonii (processed) 5,10 parts in Radix Glycyrrhizae, Borneolum Syntheticum 0.6.
Preparation method: take by weighing the above-mentioned raw materials medicine, Bombyx Batryticatus and Borneolum Syntheticum powder are broken into fine powder, and be standby; The Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Bupleuri, Semen Ziziphi Spinosae, Radix Polygalae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Rhizoma Acori Graminei, Arisaema Cum Bile, Radix Angelicae Sinensis, Radix Curcumae, Radix Glycyrrhizae, Rhizoma Typhonii (processed) decoct with water three times, adding for the first time 8～12 times of water gagings decocted 1～3 hour, adding for the second time 6～10 times of water gagings decocted 1～3 hour, adding 4～10 times of water gagings for the third time decocted 0.5～2 hour, merge three times decocting liquid, filter, filtrate decompression is condensed into relative density and is determined as 1.20～1.38 thick paste at 60 ℃, and is standby; Standby thick paste is carried in water intaking, adds standby fine powder, and with facing-up method mix homogeneously, vacuum drying is ground into fine powder, makes soft material in right amount with 80% ethanol, granulates, and drying is made capsule.
Embodiment 10
By following weight weighting raw materials (unit: gram)
Rhizoma Gastrodiae 6, Ramulus Uncariae Cum Uncis 6, Bombyx Batryticatus 6, the Radix Astragali 28, Radix Codonopsis 28, Radix Salviae Miltiorrhizae 28, Radix Bupleuri 13, Semen Ziziphi Spinosae 6, Radix Polygalae 9, Rhizoma Acori Graminei 9, Arisaema Cum Bile 9, Radix Angelicae Sinensis 28, Radix Curcumae 11, Rhizoma Typhonii (processed) 5, Massa Medicata Fermentata 5, Radix Glycyrrhizae 5, Borneolum Syntheticum 0.2.
Preparation method: take by weighing the above-mentioned raw materials medicine, Bombyx Batryticatus, Massa Medicata Fermentata and Borneolum Syntheticum powder are broken into fine powder, and be standby; The Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Bupleuri, Semen Ziziphi Spinosae, Radix Polygalae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Rhizoma Acori Graminei, Arisaema Cum Bile, Radix Angelicae Sinensis, Radix Curcumae, Radix Glycyrrhizae, Rhizoma Typhonii (processed) decoct with water three times, adding for the first time 8～12 times of water gagings decocted 1～3 hour, adding for the second time 6～10 times of water gagings decocted 1～3 hour, adding 4～10 times of water gagings for the third time decocted 0.5～2 hour, merge three times decocting liquid, filter, filtrate decompression is condensed into relative density and is determined as 1.20～1.38 thick paste at 60 ℃, and is standby; Standby thick paste is carried in water intaking, adds standby fine powder, and with facing-up method mix homogeneously, vacuum drying is ground into fine powder, makes soft material in right amount with 80% ethanol, granulates, and drying is made capsule.
Embodiment 11
By following weight weighting raw materials (unit: gram)
Rhizoma Gastrodiae 10.5, Ramulus Uncariae Cum Uncis 10.5, Bombyx Batryticatus 10.5, the Radix Astragali 14, Radix Codonopsis 14, Radix Salviae Miltiorrhizae 14, Radix Bupleuri 7, Semen Ziziphi Spinosae 10.5, Radix Polygalae 7, Rhizoma Acori Graminei 7, Arisaema Cum Bile 7, Radix Angelicae Sinensis 14, Radix Curcumae 7, Rhizoma Typhonii (processed) 3.5, Massa Medicata Fermentata 7.
Preparation method: take by weighing the above-mentioned raw materials medicine, Bombyx Batryticatus and Massa Medicata Fermentata are ground into fine powder, and be standby; The Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Bupleuri, Semen Ziziphi Spinosae, Radix Polygalae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Rhizoma Acori Graminei, Arisaema Cum Bile, Radix Angelicae Sinensis, Radix Curcumae, Rhizoma Typhonii (processed) decoct with water three times, adding for the first time 8～12 times of water gagings decocted 1～3 hour, adding for the second time 6～10 times of water gagings decocted 1～3 hour, adding 4～10 times of water gagings for the third time decocted 0.5～2 hour, merge three times decocting liquid, filter, filtrate decompression is condensed into relative density and is determined as 1.20～1.38 thick paste at 60 ℃, and is standby; Standby thick paste is carried in water intaking, adds standby fine powder, and with facing-up method mix homogeneously, vacuum drying is ground into fine powder, makes soft material in right amount with 80% ethanol, granulates, and drying is made capsule.
Embodiment 12
By following weight weighting raw materials (unit: gram)
Rhizoma Gastrodiae 10.5, Ramulus Uncariae Cum Uncis 10.5, Bombyx Batryticatus 10.5, the Radix Astragali 14, Radix Codonopsis 14, Radix Salviae Miltiorrhizae 14, Radix Bupleuri 7, Semen Ziziphi Spinosae 10.5, Radix Polygalae 7, Rhizoma Acori Graminei 7, Arisaema Cum Bile 7, Radix Angelicae Sinensis 14, Radix Curcumae 7, Rhizoma Typhonii (processed) 3.5, Radix Glycyrrhizae 7.
Preparation method: take by weighing the above-mentioned raw materials medicine, Bombyx Batryticatus is ground into fine powder, and is standby; The Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Bupleuri, Semen Ziziphi Spinosae, Radix Polygalae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Rhizoma Acori Graminei, Arisaema Cum Bile, Radix Angelicae Sinensis, Radix Curcumae, Radix Glycyrrhizae, Rhizoma Typhonii (processed) decoct with water three times, adding for the first time 8～12 times of water gagings decocted 1～3 hour, adding for the second time 6～10 times of water gagings decocted 1～3 hour, adding 4～10 times of water gagings for the third time decocted 0.5～2 hour, merge three times decocting liquid, filter, filtrate decompression is condensed into relative density and is determined as 1.20～1.38 thick paste at 60 ℃, and is standby; Standby thick paste is carried in water intaking, adds standby fine powder, and with facing-up method mix homogeneously, vacuum drying is ground into fine powder, makes soft material in right amount with 80% ethanol, granulates, and drying is made capsule.
Embodiment 13
By following weight weighting raw materials (unit: gram)
Rhizoma Gastrodiae 10.5, Ramulus Uncariae Cum Uncis 10.5, Bombyx Batryticatus 10.5, the Radix Astragali 14, Radix Codonopsis 14, Radix Salviae Miltiorrhizae 14, Radix Bupleuri 7, Semen Ziziphi Spinosae 10.5, Radix Polygalae 7, Rhizoma Acori Graminei 7, Arisaema Cum Bile 7, Radix Angelicae Sinensis 14, Radix Curcumae 7, Rhizoma Typhonii (processed) 3.5, Borneolum Syntheticum 0.6.
Preparation method: take by weighing the above-mentioned raw materials medicine, Bombyx Batryticatus and Borneolum Syntheticum powder are broken into fine powder, and be standby; The Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Bupleuri, Semen Ziziphi Spinosae, Radix Polygalae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Rhizoma Acori Graminei, Arisaema Cum Bile, Radix Angelicae Sinensis, Radix Curcumae, Rhizoma Typhonii (processed) decoct with water three times, adding for the first time 8～12 times of water gagings decocted 1～3 hour, adding for the second time 6～10 times of water gagings decocted 1～3 hour, adding 4～10 times of water gagings for the third time decocted 0.5～2 hour, merge three times decocting liquid, filter, filtrate decompression is condensed into relative density and is determined as 1.20～1.38 thick paste at 60 ℃, and is standby; Standby thick paste is carried in water intaking, adds standby fine powder, and with facing-up method mix homogeneously, vacuum drying is ground into fine powder, makes soft material in right amount with 80% ethanol, granulates, and drying is made capsule.
Embodiment 14
By following weight weighting raw materials (unit: gram)
Rhizoma Gastrodiae 10.5, Ramulus Uncariae Cum Uncis 10.5, Bombyx Batryticatus 10.5, the Radix Astragali 14, Radix Codonopsis 14, Radix Salviae Miltiorrhizae 14, Radix Bupleuri 7, Semen Ziziphi Spinosae 10.5, Radix Polygalae 7, Rhizoma Acori Graminei 7, Arisaema Cum Bile 7, Radix Angelicae Sinensis 14, Radix Curcumae 7, Rhizoma Typhonii (processed) 3.5, Massa Medicata Fermentata 7, Radix Glycyrrhizae 7.
Preparation method: take by weighing the above-mentioned raw materials medicine, Bombyx Batryticatus and Massa Medicata Fermentata are ground into fine powder, and be standby; The Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Bupleuri, Semen Ziziphi Spinosae, Radix Polygalae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Rhizoma Acori Graminei, Arisaema Cum Bile, Radix Angelicae Sinensis, Radix Curcumae, Radix Glycyrrhizae, Rhizoma Typhonii (processed) decoct with water three times, adding for the first time 8～12 times of water gagings decocted 1～3 hour, adding for the second time 6～10 times of water gagings decocted 1～3 hour, adding 4～10 times of water gagings for the third time decocted 0.5～2 hour, merge three times decocting liquid, filter, filtrate decompression is condensed into relative density and is determined as 1.20～1.38 thick paste at 60 ℃, and is standby; Standby thick paste is carried in water intaking, adds standby fine powder, and with facing-up method mix homogeneously, vacuum drying is ground into fine powder, makes soft material in right amount with 80% ethanol, granulates, and drying is made capsule.
Embodiment 15
By following weight weighting raw materials (unit: gram)
Rhizoma Gastrodiae 10.5, Ramulus Uncariae Cum Uncis 10.5, Bombyx Batryticatus 10.5, the Radix Astragali 14, Radix Codonopsis 14, Radix Salviae Miltiorrhizae 14, Radix Bupleuri 7, Semen Ziziphi Spinosae 10.5, Radix Polygalae 7, Rhizoma Acori Graminei 7, Arisaema Cum Bile 7, Radix Angelicae Sinensis 14, Radix Curcumae 7, Rhizoma Typhonii (processed) 3.5, Massa Medicata Fermentata 7, Borneolum Syntheticum 0.6.
Preparation method: take by weighing the above-mentioned raw materials medicine, Bombyx Batryticatus, Massa Medicata Fermentata and Borneolum Syntheticum powder are broken into fine powder, and be standby; The Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Bupleuri, Semen Ziziphi Spinosae, Radix Polygalae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Rhizoma Acori Graminei, Arisaema Cum Bile, Radix Angelicae Sinensis, Radix Curcumae, Rhizoma Typhonii (processed) decoct with water three times, adding for the first time 8～12 times of water gagings decocted 1～3 hour, adding for the second time 6～10 times of water gagings decocted 1～3 hour, adding 4～10 times of water gagings for the third time decocted 0.5～2 hour, merge three times decocting liquid, filter, filtrate decompression is condensed into relative density and is determined as 1.20～1.38 thick paste at 60 ℃, and is standby; Standby thick paste is carried in water intaking, adds standby fine powder, and with facing-up method mix homogeneously, vacuum drying is ground into fine powder, makes soft material in right amount with 80% ethanol, granulates, and drying is made capsule.
Embodiment 16
By following weight weighting raw materials (unit: gram)
Rhizoma Gastrodiae 10.5, Ramulus Uncariae Cum Uncis 10.5, Bombyx Batryticatus 10.5, the Radix Astragali 14, Radix Codonopsis 14, Radix Salviae Miltiorrhizae 14, Radix Bupleuri 7, Semen Ziziphi Spinosae 10.5, Radix Polygalae 7, Rhizoma Acori Graminei 7, Arisaema Cum Bile 7, Radix Angelicae Sinensis 14, Radix Curcumae 7, Rhizoma Typhonii (processed) 3.5, Radix Glycyrrhizae 7, Borneolum Syntheticum 0.6.
Preparation method: take by weighing the above-mentioned raw materials medicine, Bombyx Batryticatus and Borneolum Syntheticum powder are broken into fine powder, and be standby; The Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Bupleuri, Semen Ziziphi Spinosae, Radix Polygalae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Rhizoma Acori Graminei, Arisaema Cum Bile, Radix Angelicae Sinensis, Radix Curcumae, Radix Glycyrrhizae, Rhizoma Typhonii (processed) decoct with water three times, adding for the first time 8～12 times of water gagings decocted 1～3 hour, adding for the second time 6～10 times of water gagings decocted 1～3 hour, adding 4～10 times of water gagings for the third time decocted 0.5～2 hour, merge three times decocting liquid, filter, filtrate decompression is condensed into relative density and is determined as 1.20～1.38 thick paste at 60 ℃, and is standby; Standby thick paste is carried in water intaking, adds standby fine powder, and with facing-up method mix homogeneously, vacuum drying is ground into fine powder, makes soft material in right amount with 80% ethanol, granulates, and drying is made capsule.
Embodiment 17
By following weight weighting raw materials (unit: gram)
Rhizoma Gastrodiae 10.5, Ramulus Uncariae Cum Uncis 10.5, Bombyx Batryticatus 10.5, the Radix Astragali 14, Radix Codonopsis 14, Radix Salviae Miltiorrhizae 14, Radix Bupleuri 7, Semen Ziziphi Spinosae 10.5, Radix Polygalae 7, Rhizoma Acori Graminei 7, Arisaema Cum Bile 7, Radix Angelicae Sinensis 14, Radix Curcumae 7, Rhizoma Typhonii (processed) 3.5, Massa Medicata Fermentata 7, Radix Glycyrrhizae 7, Borneolum Syntheticum 0.6.
Preparation method: take by weighing the above-mentioned raw materials medicine, Bombyx Batryticatus, Massa Medicata Fermentata and Borneolum Syntheticum powder are broken into fine powder, and be standby; The Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Bupleuri, Semen Ziziphi Spinosae, Radix Polygalae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Rhizoma Acori Graminei, Arisaema Cum Bile, Radix Angelicae Sinensis, Radix Curcumae, Radix Glycyrrhizae, Rhizoma Typhonii (processed) decoct with water three times, adding for the first time 8～12 times of water gagings decocted 1～3 hour, adding for the second time 6～10 times of water gagings decocted 1～3 hour, adding 4～10 times of water gagings for the third time decocted 0.5～2 hour, merge three times decocting liquid, filter, filtrate decompression is condensed into relative density and is determined as 1.20～1.38 thick paste at 60 ℃, and is standby; Standby thick paste is carried in water intaking, adds standby fine powder, and with facing-up method mix homogeneously, vacuum drying is ground into fine powder, makes soft material in right amount with 80% ethanol, granulates, and drying is made capsule.
Claims (5)
1, a kind of medicine for the treatment of epilepsy clonus, infantile convulsion, facial spasm is characterized in that comprising following bulk drugs:
5～20 parts of 5～20 parts of Bombyx Batryticatus of 5～20 parts of Ramulus Uncariae Cum Uncis of Rhizoma Gastrodiae
10～30 parts of 10～30 parts of Radix Salviae Miltiorrhizaes of 10～30 parts of Radix Codonopsis of the Radix Astragali
3～15 parts of 5～20 parts of Radix Polygalaes of 3～15 parts of Semen Ziziphi Spinosaes of Radix Bupleuri
10～30 parts of 3～15 parts of Radix Angelicae Sinensis of 3～15 parts of Arisaema Cum Bile of Rhizoma Acori Graminei
1～6 part of 3～15 parts of Rhizoma Typhonii (processed) of Radix Curcumae.
2, the medicine of treatment epilepsy clonus as claimed in claim 1, infantile convulsion, facial spasm is characterized in that adding 0.2～2 part of 3～15 parts of Massa Medicata Fermentatas and/or 3～15 parts in Radix Glycyrrhizae and/or Borneolum Syntheticum in described raw material.
3, the medicine of treatment epilepsy clonus as claimed in claim 1, infantile convulsion, facial spasm is characterized in that comprising following bulk drugs:
14 parts of 10.5 parts of Radixs Astragali of 10.5 parts of Bombyx Batryticatus of 10.5 parts of Ramulus Uncariae Cum Uncis of Rhizoma Gastrodiae
10.5 parts of 7 parts of Semen Ziziphi Spinosaes of 14 parts of Radix Bupleuri of 14 parts of Radix Salviae Miltiorrhizaes of Radix Codonopsis
14 parts of 7 parts of Radix Angelicae Sinensis of 7 parts of Arisaema Cum Bile of 7 parts of Rhizoma Acori Graminei of Radix Polygalae
3.5 parts of 7 parts of Rhizoma Typhonii (processed) of Radix Curcumae.
4, the medicine of treatment epilepsy clonus as claimed in claim 3, infantile convulsion, facial spasm is characterized in that adding 0.6 part of 7 parts of Massa Medicata Fermentatas and/or 7 parts in Radix Glycyrrhizae and/or Borneolum Syntheticum in described raw material.
5, the preparation method as medicine as described in claim 1 or 3 is:
(1), Bombyx Batryticatus is ground into fine powder, and is standby;
(2), the Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Bupleuri, Semen Ziziphi Spinosae, Radix Polygalae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Rhizoma Acori Graminei, Arisaema Cum Bile, Radix Angelicae Sinensis, Radix Curcumae, Rhizoma Typhonii (processed) decoct with water three times, adding for the first time 8～12 times of water gagings decocted 1～3 hour, adding for the second time 6～10 times of water gagings decocted 1～3 hour, adding 4～10 times of water gagings for the third time decocted 0.5～2 hour, merge three times decocting liquid, filter, filtrate decompression is condensed into relative density and is determined as 1.20～1.38 thick paste at 60 ℃, and is standby;
(3), water intaking carries standby thick paste, adds standby fine powder, with facing-up method mix homogeneously, vacuum drying is ground into fine powder, makes soft material in right amount with 80% ethanol, granulation, drying is made capsule.
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| CN104547882B (en) * | 2013-10-16 | 2017-12-15 | 西安千禾药业有限责任公司 | It is a kind of treat epilepsy clonus, child convulsion, facial spasm pharmaceutical composition preparation method |
| CN103768480B (en) * | 2014-02-11 | 2015-11-04 | 高峰 | A kind of Chinese medicine for the treatment of facial spasm and preparation method thereof |
| CN103830669A (en) * | 2014-02-17 | 2014-06-04 | 刘禾青 | Chinese medicinal composition for treating infantile convulsion |
| CN103990044B (en) * | 2014-06-04 | 2018-02-23 | 河北省中医药研究院 | A kind of Chinese medicine composition for treating epilepsy, its preparation method, preparation and application |
| CN104524035A (en) * | 2014-12-19 | 2015-04-22 | 王金奎 | Traditional Chinese medicine for treating prosopospasm and preparation method thereof |
| CN104547430B (en) * | 2015-02-02 | 2018-04-27 | 邢洪霞 | Treat the instant particles as Chinese medicine and preparation method of infantile convulsion |
| CN105147911A (en) * | 2015-10-26 | 2015-12-16 | 徐志英 | Traditional Chinese medicine decoction for treating infantile convulsions |
| CN108420994B (en) * | 2018-04-26 | 2021-01-08 | 西安千禾药业股份有限公司 | A pharmaceutical composition for treating epilepsia tic convulsion, infantile convulsion, and facial spasm, and its preparation method |
| CN108815469A (en) * | 2018-08-16 | 2018-11-16 | 贵州苗之源苗药中药饮片有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating epilepsy |
| CN111632112A (en) * | 2020-06-23 | 2020-09-08 | 西安岐奥丰医疗发展有限公司 | Wind-calming and collateral-dredging preparation and preparation method thereof |
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Assignee: Beijing Lewei Bio. & Tech. Co.,Ltd. Assignor: Xian Qianhe Pharmaceutical Co., Ltd. Contract fulfillment period: 2008.9.28 to 2014.9.28 contract change Contract record no.: 2008990001321 Denomination of invention: Medicine for treating epilepsy clonus, child convulsion, prosopospasm and its preparation method Granted publication date: 20070815 License type: Exclusive license Record date: 2008.12.2 |
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Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2008.9.28 TO 2014.9.28; CHANGE OF CONTRACT Name of requester: BEIJING LEWEI BIOISYSTECH CO., LTD. Effective date: 20081202 |
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Address after: High tech Zone Zhang Bayi Road 710065 Shaanxi city of Xi'an province No. 1 Huixin IBC-B block 11 layer Patentee after: Xian Qianhe Pharmaceutical Co., Ltd. Address before: 710075 Shaanxi city of Xi'an province high tech Industrial Development Zone, high tech Road No. 52 building 17 layer Patentee before: Xian Qianhe Pharmaceutical Co., Ltd. |
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