CN101904962B - Medicament for treating cold and preparation method thereof - Google Patents
Medicament for treating cold and preparation method thereof Download PDFInfo
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- CN101904962B CN101904962B CN2010102646373A CN201010264637A CN101904962B CN 101904962 B CN101904962 B CN 101904962B CN 2010102646373 A CN2010102646373 A CN 2010102646373A CN 201010264637 A CN201010264637 A CN 201010264637A CN 101904962 B CN101904962 B CN 101904962B
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Abstract
The invention discloses a medicament for treating cold, which is characterized by being preparing mainly from the following raw materials in part by weight: 1 to 20 parts of rose, 1 to 20 parts of sevilleorange flower, 1 to 20 parts of root of kudzu vine, 1 to 20 parts of root of common peony, 1 to 20 parts of nutgrass galingale rhizome, 1 to 20 parts of rattletop, 1 to 20 parts of dried orange peel, 1 to 20 parts of ligusticum wallichii, 1 to 20 parts of radix angelicae, 1 to 20 parts of perilla nankinensis, 1 to 20 parts of ephedra, 1 to 20 parts of liquoric root, and 1 to 20 parts of over 95 percent edible alcohol. The medicament can be absorbed by spleen and stomach, by skins through external application and jointly through oral and external application. The medicament has the advantages of reasonable formula, simple mixing, exact treatment effect and symptom and root combined addressing. The invention also provides a method for preparing the medicament.
Description
Technical field
The invention belongs to the field of Chinese medicines, medicine of the treatment flu of particularly a kind of oral administration or external and preparation method thereof.
Background technology
Flu is the common exogenous diseases due to the ailment said due to cold or exposure invasion and attack human body, with fever with chills, and head-body-pain, the nasal obstruction watery nasal discharge, throat itching and cough is the disease of main performance.Flu is divided into common cold and influenza generally.Common cold, the traditional Chinese medical science claim " cold ", are a kind of respiratory tract commonly encountered diseases that is caused by multiple virus, and wherein 30%-50% is that rhinovirus by certain serotype causes.Though common cold is mainly in early winter, in any season, as can taking place in spring, summer, the Causative virus of the flu of Various Seasonal is not just the same yet.Influenza is the acute respiratory infectious disease that is caused by influenza virus.Virus is present in patient's the respiratory tract, gives others through droplet infection when patient's cough, sneeze.
Chinese patent CN200610140570.6 discloses a kind of Chinese medicine preparation for the treatment of flu, and it is a raw material with Herba Schizonepetae, Radix Saposhnikoviae, Folium Perillae, Rhizoma Et Radix Notopterygii, living Radix Bupleuri, stir-baked SEMEN ARMENIACAE AMARUM, Radix Peucedani, Radix Platycodonis and Semen Raphani (parched), makes various peroral dosage forms.Chinese patent CN200510095620.9 discloses a kind of Chinese medicine preparation for the treatment of flu, is formed by following raw medicinal material configuration: Fructus Forsythiae, Herba Andrographis, Rhizoma Et Radix Notopterygii, Herba Commelinae, Herba Menthae, Radix Trichosanthis.Preparation technology is by vapor distillation part medical material, and water is carried again, and processes such as filtration concentrate and obtain extractum.In extractum, add suitable adjuvant, promptly can be made into various dosage forms according to common process.Chinese patent CN200710015868.9 discloses the Chinese medicine composition of a kind of prevention and treatment flu, is made up of following medicine: Herba Pogostemonis, Folium Mori, Radix Isatidis, Flos Lonicerae, Fructus Forsythiae, Rhizoma Osmundae, Radix Platycodonis, Rhizoma Belamcandae, Radix Glycyrrhizae.
The Chinese medicine product of above-mentioned treatment flu is paid attention to regulating too much, has reduced the medicine proportion of a therapeutical effect relatively, has influenced the pharmic function performance, so effect is slow, the course of treatment is long, and effect is undesirable.And existing Chinese medicine oral administration but can not external, but can not the taking orally again of external, route of administration is single, makes the patient slow to the absorption of medicine.Chinese medicine for oral administration not only absorbs slowly, and causes spleen injury easily, even increase the weight of the state of an illness for the patient of weakness of the spleen and stomach.
Chinese medicine is taken difficulty owing to mostly be decoction or the pill that boils than Western medicine, has also influenced the popularization of Chinese medicine widely.
Summary of the invention
The objective of the invention is to overcome the defective that prior art exists, a kind of reasonable recipe is provided, compatibility is simplified, the medicine of the treatment of determined curative effect, treating both the principal and secondary aspects of a disease flu, to control, control foster combination, and this medicine can take orally by taste absorb again can external by skin absorbs, can also oral administration and externally used dual mode composite absorption.This compound administering mode helps the efficient absorption of human body to medicine, and for the crowd of weakness of the spleen and stomach, the medicine that is busy with one's work, spares oneself provides multiple choices, especially the patient by the modern job crowd is accepted.
Technical scheme of the present invention is as follows:
A kind of medicine for the treatment of flu is characterized in that it mainly is to be made by the raw material of following weight portion: 1 ~ 20 part of Flos Rosae Rugosae, 1 ~ 20 part of CitrusaurantiumL.Var.amara Engl., 1 ~ 20 part of Radix Puerariae, 1 ~ 20 part of Radix Paeoniae Rubra, 1 ~ 20 part of Rhizoma Cyperi, 1 ~ 20 part of Rhizoma Cimicifugae, 1 ~ 20 part of Pericarpium Citri Reticulatae, 1 ~ 20 part of Rhizoma Chuanxiong, 1 ~ 20 part of the Radix Angelicae Dahuricae, 1 ~ 20 part of Folium Perillae, 1 ~ 20 part in Herba Ephedrae, 1 ~ 20 part in Radix Glycyrrhizae, content is 1 ~ 20 part of edible ethanol more than 95%.
Further, the consumption of each component of medicine of the present invention is: 15 ~ 20 parts of Flos Rosae Rugosaes, 15 ~ 20 parts of CitrusaurantiumL.Var.amara Engl.s, 15 ~ 20 parts of Radix Puerariaes, 15 ~ 20 parts of Radix Paeoniae Rubra, 15 ~ 20 parts of Rhizoma Cyperis, 15 ~ 20 parts of Rhizoma Cimicifugaes, 15 ~ 20 parts of Pericarpium Citri Reticulataes, 15 ~ 20 parts of Rhizoma Chuanxiongs, 15 ~ 20 parts of the Radixs Angelicae Dahuricae, 15 ~ 20 parts of Folium Perillaes, 15 ~ 20 parts in Herba Ephedrae, 15 ~ 20 parts in Radix Glycyrrhizae, content is 15 ~ 20 parts of edible ethanols more than 95%.
The middle survival dose of above compatibility is the crude drug amount.
In order to strengthen the transdermal effect of medicine, can also mix transdermal agent in the medicine of the present invention, preferably weight portion is 1 ~ 5 part a azone.
Another object of the present invention provides manufacturing method for above mentioned medicine, it is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Radix Puerariae, Radix Paeoniae Rubra, Rhizoma Cyperi, Rhizoma Cimicifugae, Pericarpium Citri Reticulatae, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Folium Perillae, Herba Ephedrae and the Radix Glycyrrhizae of described weight proportion, according to the conventional extracting method of Chinese medicine, the extract of the former medicine that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds described weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrate sterilization, fill according to quantity must be treated the medicine of flu.
Further, among the step c, can add in the aqueous solution of alcohol together by azone step a is extract obtained and 1 ~ 5 weight portion.
The conventional extracting method of described Chinese crude drug can adopt decocting method, circumfluence method, infusion process, percolation, semi-bionic extraction, supercritical fluid extraction, microwave extraction method etc. according to the kind of medical material.
The present invention is directed to the characteristics of flu, select Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Radix Puerariae, Radix Paeoniae Rubra, Rhizoma Cyperi, Rhizoma Cimicifugae, Pericarpium Citri Reticulatae, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Folium Perillae, Herba Ephedrae, Radix Glycyrrhizae for use, with being that edible ethanol more than 95% mixes with content after each flavor Chinese medicine extraction, make to contain pure Chinese medicine extraction liquid.Employing to be to control, and control and support bonded method, but not only also external of oral administration of the medicine of making is a kind of reasonable recipe, and compatibility is simplified, the medicine of the treatment flu of determined curative effect, treating both the principal and secondary aspects of a disease.
Radix Puerariae yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness ends temperature, cold, the warm headache stiffness of the nape that cures the wound, dysphoria with smothery sensation is quenched one's thirst.The Radix Paeoniae Rubra bitter in the mouth, cool in nature, clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.The Rhizoma Cyperi resolving depression of regulating the flow of vital energy.The Rhizoma Cimicifugae yang invigorating is delivered, rash, and the seasonal epidemic pathogens epidemic disease is controlled in detoxifcation, headache cold and heat, laryngalgia.Pericarpium Citri Reticulatae nature and flavor suffering, hardship, temperature are gone into spleen, lung meridian; The merit that appetizing, drying dampness to eliminate phlegm in circulation of qi promoting spleen invigorating, stopping nausea and vomiting by lowering the adverse flow of QI, the accent are arranged.The Rhizoma Chuanxiong activating QI to alleviate the depression, the method wind-dryness is wet, promoting blood circulation and stopping pain.The Radix Angelicae Dahuricae dispels the wind, dampness, detumescence, pain relieving.Folium Perillae is delivered, and cold expelling is regulated the flow of vital energy, and battalion.The Herba Ephedrae diaphoresis is relievingd asthma, diuretic.The cold table that cures the wound is real, and fever with chills is lossless, headache is had a stuffy nose, arthralgia; Cough and asthma.Radix Glycyrrhizae and middle emergency, lung moistening, detoxifcation, coordinating the actions of various ingredients in a prescription.
Medicine of the present invention is temperature slightly partially, with Herba Ephedrae, Folium Perillae relieving the exterior syndrome by diaphoresis; Rhizoma Cimicifugae, the cough-relieving of Radix Puerariae lung qi dispersing are brought down a fever and are promoted the production of body fluid; Pericarpium Citri Reticulatae, Rhizoma Cyperi regulating the flow of QI to ease the stomach; Rhizoma Chuanxiong, Radix Angelicae Dahuricae wind-expelling pain-stopping; Radix Paeoniae Rubra, Radix Glycyrrhizae heat-clearing and toxic substances removing.In addition, Herba Ephedrae has the effect of the influenza virus of inhibition, and Radix Paeoniae Rubra has the good sedative analgesic activity; And antimicrobial spectrum is also more extensive, thereby can obtain comparatively significant curative effect to the infection of upper respiratory tract.
Flos Rosae Rugosae regulate the flow of vital energy resolving depression and blood dissipating blood stasis; The CitrusaurantiumL.Var.amara Engl. the chest stuffiness relieving of regulating the flow of vital energy, dispersing the stagnated liver-QI for regulating the stomach, appetizing preventing or arresting vomiting.Two medicines, 5 usefulness, a gas one blood, QI and blood is two transfers, eliminating turbid pathogen with aromatics, the appetizing of being amusing, the strength enhancing that absorbs the drug when oral.Content is the edible ethanol blood circulation promoting and blood stasis dispelling more than 95%, promotes that drug osmotic to cell absorbs, and auxiliary taste absorb to improve curative effect when oral; Outer time spent skin expansion pore is to strengthen the drug transdermal trap.
Medicine of the present invention can also be smeared by whole body except for oral administration.Adopt oral administration and externally usedly, drug effect is more remarkable.
It is evident in efficacy that the present invention treats flu, short treating period, and through clinical 100 routine patients' clinical verification, curing number is 80 examples, and significant figure is 18 examples, and invalid number is 2 examples, and total effective rate reaches 98%.Clinical usefulness repeatly, effect are very prompt, do not see toxic side effect in the therapeutic process, and the patient has better curative effect to obstinate.
For further specifying therapeutic effect, it is as follows now to enumerate model case:
Case 1: certain woman 32 years old, flu a few days, fever, cough, watery nasal discharge.Oral medicine of the present invention, each 10 milliliters, every day 3 times, above symptom was alleviated in 2 days, eliminated in 3 days.Fever, cough, watery nasal discharge were paid a return visit after 1 month does not have recurrence.
Case 2: certain woman 41 years old, flu a few days, alternation of chills and fever, diarrhea and vomiting.External medicine of the present invention is smeared whole body and abdominal part, every day 2 times, each 10 milliliters.Above symptom was alleviated in 2 days, eliminated in 2 days.Paying a return visit after 2 months does not have recurrence.
Case 3: certain man 62 years old, catch a cold a few days fever and headache, laryngopharynx swelling and pain.Oral medicine of the present invention, each 10 milliliters, every day 3 times; This medicine of external smear whole body and the head, throat, every day 2 times, each 10 milliliters.Oral and external was alleviated the same day, eliminated in 2 days.Paying a return visit after 1 month does not have recurrence.
The specific embodiment
Embodiment 1
Take by weighing 15 parts of Flos Rosae Rugosaes, 16 parts of CitrusaurantiumL.Var.amara Engl.s, 15 parts of Radix Puerariaes, 18 parts of Radix Paeoniae Rubra, 19 parts of Rhizoma Cyperis, 20 parts of Rhizoma Cimicifugaes, 17 parts of Pericarpium Citri Reticulataes, 15 parts of Rhizoma Chuanxiongs, 15 parts of the Radixs Angelicae Dahuricae, 20 parts of Folium Perillaes, 16 parts in Herba Ephedrae, 16 parts in Radix Glycyrrhizae adopts the method that decocts the back concentrating under reduced pressure to make Chinese medicine extract respectively, and is standby.
Under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add content and be 18 parts of 96% edible ethanols, be mixed with aqueous solution of alcohol, standby.
Above-mentioned various Chinese medicine extract are added in the aqueous solution of alcohol, fully stirred 120 minutes, precipitate 2 ~ 4 hours, supernatant 200 orders filter, and the medicine that gained filtrate is the treatment flu of oral administration or external carries out fill under aseptic condition.Gained precipitate and filtering residue focus on.
Embodiment 2
The drug component proportioning is: 18 parts of Flos Rosae Rugosaes, and 18 parts of CitrusaurantiumL.Var.amara Engl.s, 19 parts of Radix Puerariaes, 18 parts of Radix Paeoniae Rubra, 18 parts of Rhizoma Cyperis, 19 parts of Rhizoma Cimicifugaes, 20 parts of Pericarpium Citri Reticulataes, 20 parts of Rhizoma Chuanxiongs, 18 parts of the Radixs Angelicae Dahuricae, 19 parts of Folium Perillaes, 19 parts in Herba Ephedrae, 20 parts in Radix Glycyrrhizae, content is 18 parts of 97% edible ethanols.Other is identical with embodiment 1.
Embodiment 3
The drug component proportioning is: 19 parts of Flos Rosae Rugosaes, and 19 parts of CitrusaurantiumL.Var.amara Engl.s, 19 parts of Radix Puerariaes, 20 parts of Radix Paeoniae Rubra, 20 parts of Rhizoma Cyperis, 20 parts of Rhizoma Cimicifugaes, 19 parts of Pericarpium Citri Reticulataes, 19 parts of Rhizoma Chuanxiongs, 19 parts of the Radixs Angelicae Dahuricae, 20 parts of Folium Perillaes, 20 parts in Herba Ephedrae, 19 parts in Radix Glycyrrhizae, content is 18 parts of 98% edible ethanols.Other is identical with embodiment 1.
Embodiment 4
The drug component proportioning is: 16 parts of Flos Rosae Rugosaes, and 16 parts of CitrusaurantiumL.Var.amara Engl.s, 17 parts of Radix Puerariaes, 18 parts of Radix Paeoniae Rubra, 19 parts of Rhizoma Cyperis, 17 parts of Rhizoma Cimicifugaes, 18 parts of Pericarpium Citri Reticulataes, 20 parts of Rhizoma Chuanxiongs, 16 parts of the Radixs Angelicae Dahuricae, 18 parts of Folium Perillaes, 19 parts in Herba Ephedrae, 17 parts in Radix Glycyrrhizae, content is 16 parts of 98% edible ethanols.Other is identical with embodiment 1.
Embodiment 5
The drug component proportioning is: 17 parts of Flos Rosae Rugosaes, and 18 parts of CitrusaurantiumL.Var.amara Engl.s, 20 parts of Radix Puerariaes, 17 parts of Radix Paeoniae Rubra, 19 parts of Rhizoma Cyperis, 17 parts of Rhizoma Cimicifugaes, 16 parts of Pericarpium Citri Reticulataes, 20 parts of Rhizoma Chuanxiongs, 16 parts of the Radixs Angelicae Dahuricae, 17 parts of Folium Perillaes, 19 parts in Herba Ephedrae, 20 parts in Radix Glycyrrhizae, content is 19 parts of 99% edible ethanols.Other is identical with embodiment 1.
Embodiment 6
The drug component proportioning is: 18 parts of Flos Rosae Rugosaes, and 16 parts of CitrusaurantiumL.Var.amara Engl.s, 16 parts of Radix Puerariaes, 18 parts of Radix Paeoniae Rubra, 19 parts of Rhizoma Cyperis, 18 parts of Rhizoma Cimicifugaes, 19 parts of Pericarpium Citri Reticulataes, 16 parts of Rhizoma Chuanxiongs, 20 parts of the Radixs Angelicae Dahuricae, 20 parts of Folium Perillaes, 17 parts in Herba Ephedrae, 18 parts in Radix Glycyrrhizae, content is 20 parts of 100% edible ethanols.Other is identical with embodiment 1.
Claims (5)
1. a medicine for the treatment of flu is characterized in that it is to be made by the raw material of following weight portion: 1 ~ 20 part of Flos Rosae Rugosae, 1 ~ 20 part of CitrusaurantiumL.Var.amara Engl., 1 ~ 20 part of Radix Puerariae, 1 ~ 20 part of Radix Paeoniae Rubra, 1 ~ 20 part of Rhizoma Cyperi, 1 ~ 20 part of Rhizoma Cimicifugae, 1 ~ 20 part of Pericarpium Citri Reticulatae, 1 ~ 20 part of Rhizoma Chuanxiong, 1 ~ 20 part of the Radix Angelicae Dahuricae, 1 ~ 20 part of Folium Perillae, 1 ~ 20 part in Herba Ephedrae, 1 ~ 20 part in Radix Glycyrrhizae, content is 1 ~ 20 part of edible ethanol more than 95%.
2. medicine as claimed in claim 1 is characterized in that it is to be made by the raw material of following weight portion: 15 ~ 20 parts of Flos Rosae Rugosaes, 15 ~ 20 parts of CitrusaurantiumL.Var.amara Engl.s, 15 ~ 20 parts of Radix Puerariaes, 15 ~ 20 parts of Radix Paeoniae Rubra, 15 ~ 20 parts of Rhizoma Cyperis, 15 ~ 20 parts of Rhizoma Cimicifugaes, 15 ~ 20 parts of Pericarpium Citri Reticulataes, 15 ~ 20 parts of Rhizoma Chuanxiongs, 15 ~ 20 parts of the Radixs Angelicae Dahuricae, 15 ~ 20 parts of Folium Perillaes, 15 ~ 20 parts in Herba Ephedrae, 15 ~ 20 parts in Radix Glycyrrhizae, content is 15 ~ 20 parts of edible ethanols more than 95%.
3. medicine as claimed in claim 1 or 2 is characterized in that, further contains weight portion and be 1 ~ 5 part azone on the basis of claim 1 or 2 described medicines.
4. the preparation method of claim 1 or 2 described medicines is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Radix Puerariae, Radix Paeoniae Rubra, Rhizoma Cyperi, Rhizoma Cimicifugae, Pericarpium Citri Reticulatae, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Folium Perillae, Herba Ephedrae and the Radix Glycyrrhizae of described weight proportion, according to the conventional extracting method of Chinese medicine, the extract of the raw material that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds described weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrate sterilization, fill according to quantity must be treated the medicine of flu.
5. the preparation method of the described medicine of claim 3 is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Radix Puerariae, Radix Paeoniae Rubra, Rhizoma Cyperi, Rhizoma Cimicifugae, Pericarpium Citri Reticulatae, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Folium Perillae, Herba Ephedrae and the Radix Glycyrrhizae of described weight proportion, according to the conventional extracting method of Chinese medicine, the extract of the raw material that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds described weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) azone step a is extract obtained and described weight proportion adds in the aqueous solution of alcohol together, stirs 120 minutes, precipitates 2 ~ 4 hours, filter, and gained filtrate sterilization, fill according to quantity must be treated the medicine of flu.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102646373A CN101904962B (en) | 2010-08-27 | 2010-08-27 | Medicament for treating cold and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102646373A CN101904962B (en) | 2010-08-27 | 2010-08-27 | Medicament for treating cold and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101904962A CN101904962A (en) | 2010-12-08 |
| CN101904962B true CN101904962B (en) | 2011-10-05 |
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| CN2010102646373A Expired - Fee Related CN101904962B (en) | 2010-08-27 | 2010-08-27 | Medicament for treating cold and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105616707A (en) * | 2016-03-31 | 2016-06-01 | 杨登新 | Traditional Chinese medicine for treating external cold and internal heat type cold and preparation method of traditional Chinese medicine |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1225266A (en) * | 1998-02-06 | 1999-08-11 | 王伊斌 | Liquid medicine for treating cold |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1225266A (en) * | 1998-02-06 | 1999-08-11 | 王伊斌 | Liquid medicine for treating cold |
Non-Patent Citations (2)
| Title |
|---|
| 平安居.感冒的中医证治.《现代养生》.2001,(第3期),第34-35页. * |
| 杨华祥.感冒的中医辨治体会.《中国社区医师》.2008,第10卷(第7期),第80页. * |
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