CN101972371B - Medicament for treating hemicrania and preparation method thereof - Google Patents
Medicament for treating hemicrania and preparation method thereof Download PDFInfo
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- CN101972371B CN101972371B CN2010102636719A CN201010263671A CN101972371B CN 101972371 B CN101972371 B CN 101972371B CN 2010102636719 A CN2010102636719 A CN 2010102636719A CN 201010263671 A CN201010263671 A CN 201010263671A CN 101972371 B CN101972371 B CN 101972371B
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Abstract
The invention discloses a medicament for treating hemicrania. The medicament is characterized in that: the medicament is prepared from the following raw materials in part by weight: 1 to 20 parts of rose, 1 to 20 parts of Seville orange flower, 1 to 20 parts of raw aconite, 1 to 20 parts of raw arisaema, 1 to 20 parts of raw giant typhonium rhizome and 1 to 20 parts of edible alcohol, wherein the edible alcohol content of the medicament is over 95 percent. The medicament can be taken orally and absorbed by the spleen and the stomach, applied externally and absorbed by the skin, and absorbed by combining the two ways of external administration and the external application, is rational in prescription, simple to dispense and confirmed in curative effect, and seeks both temporary and permanent solutions. The invention also provides a preparation method for the medicament.
Description
Technical field
The invention belongs to the field of Chinese medicines, migrainous medicine of treatment of particularly a kind of oral administration or external and preparation method thereof.
Background technology
Migraine belongs to a kind of periodical attack disease that family's morbidity tendency is arranged.Show as paroxysmal inclined to one side side pulsatile headache, the companion feels sick, vomiting, falls ill once more through an intersegmental after date of having a rest.Headache is alleviated in peace and quiet, dark surrounds or after the sleep.Can be before headache takes place or during outbreak with nerve, moral function obstacle.
When the migraine disease people has a headache outbreak, generally all be confined to a side of head, the position of headache can change when the patient who has showed effect at every turn, visible occipitalia that has and crown pain, and the patient who also has shows as face and cervical pain.
Many scholars, doctor carry out excessive quantity research to migraine, but the migrainous cause of disease it be not immediately clear.
Chinese patent CN200310112651.1 discloses the migrainous Chinese medicine composition of a kind of treatment, and component comprises: Rhizoma Chuanxiong, and Radix Angelicae Sinensis, Fructus Viticis, Scorpio, the artificial Moschus, Borneolum Syntheticum is made oral formulations such as soft capsule, hard capsule, granule, tablet, oral liquid.Chinese patent CN200710114110.0 discloses a kind of taking orally and has been used for the treatment of migrainous Chinese medicine composition, and it is formulated to press constant weight by Radix Puerariae, Ramulus Cinnamomi, Radix Paeoniae Alba (parched), Rhizoma Zingiberis Recens, Fructus Jujubae, Herba Taraxaci, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Radix Curcumae, Rhizoma Acori Graminei, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Radix Aconiti, Rhizoma Gastrodiae, Bombyx Batryticatus, Semen Sinapis Albae, Herba Asari and Radix Glycyrrhizae.With Impurity removal in the above-mentioned raw materials, be decocted in water for oral dose during compounding pharmaceutical.Chinese patent CN200810016188.3 discloses the migrainous Chinese medicine composition of a kind of treatment, comprise following component: 30～40 parts of Rhizoma Chuanxiongs, 10～15 parts of Radix Bupleuri, 5～10 parts of Rhizoma Cyperis, 10～20 parts of Radix Cyathulaes, 10～15 parts of Semen Sinapis Albaes, 5～10 parts of the Radixs Angelicae Dahuricae, 10～15 parts of Semen Prunis are made capsule, tablet or oral liquid according to a conventional method.
The migrainous Chinese medicine product of above-mentioned treatment is paid attention to regulating too much, and used taste of Chinese medicine number is too much, has reduced the medicine proportion of a therapeutical effect relatively, has influenced the pharmic function performance, so effect is slow, the course of treatment is long, and effect is undesirable.And existing Chinese medicine oral administration but can not external, but can not the taking orally again of external, route of administration is single, makes the patient slow to the absorption of medicine.Chinese medicine for oral administration not only absorbs slowly, and causes spleen injury easily, even increase the weight of the state of an illness for the patient of weakness of the spleen and stomach.
Chinese medicine is taken difficulty owing to mostly be decoction or the pill that boils than Western medicine, has also influenced the popularization of Chinese medicine widely.
Summary of the invention
The objective of the invention is to overcome the defective that prior art exists, a kind of reasonable recipe is provided, compatibility is simplified, the migrainous medicine of treatment of determined curative effect, treating both the principal and secondary aspects of a disease, to control, control foster combination, and this medicine can take orally by taste absorb again can external by skin absorbs, can also oral administration and externally used dual mode composite absorption.Multiple administering mode is convenient to the efficient absorption of human body to medicine, and for the crowd of weakness of the spleen and stomach, the medicine that is busy with one's work, spares oneself provides multiple choices, especially the patient by the modern job crowd is accepted.
Technical scheme of the present invention is as follows:
The migrainous medicine of a kind of treatment is characterized in that it mainly is to be made by the raw material of following weight portion: 1 ~ 20 part of Flos Rosae Rugosae, 1 ~ 20 part of CitrusaurantiumL.Var.amara Engl., give birth to 1 ~ 20 part of Aconitum carmichjaelii Debx., 1 ~ 20 part of Rhizoma Arisaematis is given birth to 1 ~ 20 part of Rhizoma Typhonii, and content is 1 ~ 20 part of edible ethanol more than 95%.
Further, the consumption of each component of medicine of the present invention is: 15 ~ 20 parts of Flos Rosae Rugosaes, and 15 ~ 20 parts of CitrusaurantiumL.Var.amara Engl.s give birth to 3 ~ 8 parts of Aconitum carmichjaelii Debx.s, and 3 ~ 8 parts of Rhizoma Arisaematis are given birth to 3 ~ 8 parts of Rhizoma Typhoniis, and content is 15 ~ 20 parts of edible ethanols more than 95%.
The middle survival dose of above compatibility is the crude drug amount.
In order to strengthen the transdermal effect of medicine, can also mix transdermal agent in the medicine of the present invention, preferably weight portion is 1 ~ 5 part a azone.
Another object of the present invention provides manufacturing method for above mentioned medicine, it is characterized in that comprising the following steps:
A) take by weighing described weight proportion Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., give birth to Aconitum carmichjaelii Debx., Rhizoma Arisaematis, give birth to Rhizoma Typhonii, according to the conventional extracting method of Chinese medicine,, the extract of the former medicine that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds described weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrate sterilization, fill according to quantity must be treated migrainous medicine.
Further, among the step c, can add in the aqueous solution of alcohol together by azone step a is extract obtained and 1 ~ 5 weight portion.
The conventional extracting method of described Chinese crude drug can adopt decocting method, circumfluence method, infusion process, percolation, semi-bionic extraction, supercritical fluid extraction, microwave extraction method etc. according to the kind of medical material.
The present invention uses for reference " formulary of peaceful benevolent dispensary ", at migrainous characteristics, select Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl. for use, give birth to Aconitum carmichjaelii Debx., Rhizoma Arisaematis, give birth to the Rhizoma Typhonii Chinese medicine of the five flavours,, make to contain pure Chinese medicine extraction liquid being that edible ethanol more than 95% mixes with content after each flavor Chinese medicine extraction.Employing to be to control, and control and support bonded method, but not only also external of oral administration of the medicine of making is a kind of reasonable recipe, and compatibility is simplified, the migrainous medicine of treatment of determined curative effect, treating both the principal and secondary aspects of a disease.
Aconitum carmichjaelii Debx. expelling wind and removing dampness, antalgic; The Rhizoma Arisaematis drying dampness to eliminate phlegm, expelling wind and relieving convulsion, mass dissipating and swelling eliminating; Give birth to Rhizoma Typhonii dispel the wind expectorant, the meridian dredging, detoxifcation analgesia.
Wherein give birth to Aconitum carmichjaelii Debx., Rhizoma Arisaematis, giving birth to Rhizoma Typhonii, (being called for short the three lives) without the process of preparing Chinese medicine, the efficacy of a drug is swift and violent, and stronger cold relieving analgesic effect is arranged.Flos Rosae Rugosae regulate the flow of vital energy resolving depression and blood dissipating blood stasis; The CitrusaurantiumL.Var.amara Engl. the chest stuffiness relieving of regulating the flow of vital energy, dispersing the stagnated liver-QI for regulating the stomach, appetizing preventing or arresting vomiting.Two medicines, 5 usefulness, a gas one blood, QI and blood is two transfers, and the strength of eliminating turbid pathogen with aromatics, be amusing appetizing, regulating QI to relieve pain strengthens.Content is the edible ethanol blood circulation promoting and blood stasis dispelling more than 95%, promotes that drug osmotic to cell absorbs.
Medicine of the present invention can be smeared the affected part with medicine of the present invention except for oral administration, and the efficacy of a drug sick institute that goes directly so can remove the hardship of patient's headache, obtains and imitates in no time.This medicine is applicable to that also whole body smears.Adopt oral administration and externally usedly, drug effect is more remarkable.
Medicine of the present invention is through clinical 150 routine patients' clinical verification, and curing number is 120 examples, and significant figure is 24 examples, and invalid number is 6 examples, and total effective rate reaches 96%.Do not see toxic side effect in the therapeutic process, the patient has better curative effect to obstinate.
For further specifying therapeutic effect, it is as follows now to enumerate model case:
Case 1: certain man, 54 years old, suffered from migraine nearly ten years, through the western medical treatment poor effect, not with the long-term intermittent headache in the right before this medicine, dizzy.Oral medicine, each 10 milliliters, every day 3 times, above disease was eliminated in 2 days.Adhered to taking 15 days.Paying a return visit after 6 months does not have recurrence.
Case 2: certain man, 51 years old, suffered from migraine 5 years, not with the long-term intermittent headache in the right before this medicine, dizzy.This medicine of external is smeared whole body and head, and every day 2 times, each 10 milliliters, above disease was eliminated in 1 day.Adhered to external 15 days.Paying a return visit after 8 months does not have recurrence.
Case 3: certain woman, 45 years old, suffered from migraine 7 years, once took the migrainous Chinese medicine of a variety of treatments, but effect is all not good, and the long-term intermittent headache in the head left side, dizzy.Oral medicine, each 10 milliliters, every day 3 times; This medicine of external is smeared whole body and head, every day 2 times, each 10 milliliters.Above disease was eliminated in 1 day.Adhered to external 15 days.Paying a return visit after 8 months does not have recurrence.After oral and the external each 1 time 1 hour, pain was eliminated substantially.Adhered to using 10 days.Paying a return visit after 12 months does not have recurrence.
The specific embodiment
Embodiment 1
Take by weighing 15 parts of Flos Rosae Rugosaes, 18 parts of CitrusaurantiumL.Var.amara Engl.s give birth to 5 parts of Aconitum carmichjaelii Debx.s, and 5 parts of Rhizoma Arisaematis are given birth to 5 parts of Rhizoma Typhoniis, adopt the method that decocts the back concentrating under reduced pressure to make Chinese medicine extract respectively, and are standby.
Under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add content and be 18 parts of 96% edible ethanols, be mixed with aqueous solution of alcohol, standby.
Above-mentioned various Chinese medicine extract are added in the aqueous solution of alcohol, fully stirred 120 minutes, precipitate 2 ~ 4 hours, supernatant 200 orders filter, and the migrainous medicine of treatment that gained filtrate is oral administration or external carries out fill under aseptic condition.Gained precipitate and filtering residue focus on.
Embodiment 2
The drug component proportioning is: 18 parts of Flos Rosae Rugosaes, and 19 parts of CitrusaurantiumL.Var.amara Engl.s give birth to 5 parts of Aconitum carmichjaelii Debx.s, and 5 parts of Rhizoma Arisaematis are given birth to 5 parts of Rhizoma Typhoniis, and content is 18 parts of 97% edible ethanols.Other is identical with embodiment 1.
Embodiment 3
The drug component proportioning is: 19 parts of Flos Rosae Rugosaes, and 20 parts of CitrusaurantiumL.Var.amara Engl.s give birth to 5 parts of Aconitum carmichjaelii Debx.s, and 5 parts of Rhizoma Arisaematis are given birth to 5 parts of Rhizoma Typhoniis, and content is 18 parts of 98% edible ethanols.Other is identical with embodiment 1.
Embodiment 4
The drug component proportioning is: 15 parts of Flos Rosae Rugosaes, and 15 parts of CitrusaurantiumL.Var.amara Engl.s give birth to 8 parts of Aconitum carmichjaelii Debx.s, and 8 parts of Rhizoma Arisaematis are given birth to 8 parts of Rhizoma Typhoniis, and content is 20 parts of 99% edible ethanols.Other is identical with embodiment 1.
Embodiment 5
The drug component proportioning is: 20 parts of Flos Rosae Rugosaes, and 20 parts of CitrusaurantiumL.Var.amara Engl.s give birth to 3 parts of Aconitum carmichjaelii Debx.s, and 3 parts of Rhizoma Arisaematis are given birth to 3 parts of Rhizoma Typhoniis, and content is 16 parts of 100% edible ethanols.Other is identical with embodiment 1.
Embodiment 6
The drug component proportioning is: 16 parts of Flos Rosae Rugosaes, and 16 parts of CitrusaurantiumL.Var.amara Engl.s give birth to 6 parts of Aconitum carmichjaelii Debx.s, and 6 parts of Rhizoma Arisaematis are given birth to 6 parts of Rhizoma Typhoniis, and content is 18 parts of 97% edible ethanols.Other is identical with embodiment 1.
Claims (5)
1. migrainous medicine of treatment is characterized in that it is to be made by the raw material of following weight portion: 1 ~ 20 part of Flos Rosae Rugosae, and 1 ~ 20 part of CitrusaurantiumL.Var.amara Engl. gives birth to 1 ~ 20 part of Aconitum carmichjaelii Debx., and 1 ~ 20 part of Rhizoma Arisaematis is given birth to 1 ~ 20 part of Rhizoma Typhonii, and content is 1 ~ 20 part of edible ethanol more than 95%.
2. medicine as claimed in claim 1 is characterized in that it is to be made by the raw material of following weight portion: 15 ~ 20 parts of Flos Rosae Rugosaes, 15 ~ 20 parts of CitrusaurantiumL.Var.amara Engl.s, give birth to 3 ~ 8 parts of Aconitum carmichjaelii Debx.s, 3 ~ 8 parts of Rhizoma Arisaematis are given birth to 3 ~ 8 parts of Rhizoma Typhoniis, and content is 15 ~ 20 parts of edible ethanols more than 95%.
3. medicine as claimed in claim 1 or 2 is characterized in that, further contains weight portion and be 1 ~ 5 part azone on the basis of the described medicine of claim 1 or 2.
4. the preparation method of claim 1 or 2 described medicines is characterized in that comprising the following steps:
A) take by weighing described weight proportion Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., give birth to Aconitum carmichjaelii Debx., Rhizoma Arisaematis, give birth to Rhizoma Typhonii, according to the conventional extracting method of Chinese medicine, the extract of the raw material that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds described weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrate sterilization, fill according to quantity must be treated migrainous medicine.
5. the preparation method of medicine as claimed in claim 3 is characterized in that comprising the following steps:
A) take by weighing described weight proportion Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., give birth to Aconitum carmichjaelii Debx., Rhizoma Arisaematis, give birth to Rhizoma Typhonii, according to the conventional extracting method of Chinese medicine, the extract of the raw material that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds described weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) azone step a is extract obtained and described weight proportion adds in the aqueous solution of alcohol together, stirs 120 minutes, precipitates 2 ~ 4 hours, filter, and gained filtrate sterilization, fill according to quantity must be treated migrainous medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2010102636719A CN101972371B (en) | 2010-08-26 | 2010-08-26 | Medicament for treating hemicrania and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102636719A CN101972371B (en) | 2010-08-26 | 2010-08-26 | Medicament for treating hemicrania and preparation method thereof |
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| CN101972371A CN101972371A (en) | 2011-02-16 |
| CN101972371B true CN101972371B (en) | 2011-09-14 |
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| CN2010102636719A Expired - Fee Related CN101972371B (en) | 2010-08-26 | 2010-08-26 | Medicament for treating hemicrania and preparation method thereof |
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Citations (5)
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| CN1113777A (en) * | 1994-06-20 | 1995-12-27 | 郭昌毕 | Xugu powder for promoting reunion of fractured bones and its producing method |
| CN1116935A (en) * | 1994-07-06 | 1996-02-21 | 郭俊京 | Analgesic plaster |
| CN1161229A (en) * | 1997-01-23 | 1997-10-08 | 陈宝朝 | Traditional Chinese medicine for treating apoplexy and method for preparing same |
| CN1413704A (en) * | 2002-11-19 | 2003-04-30 | 贵州万胜药业有限责任公司 | Huafeng pill |
| CN101716325A (en) * | 2009-12-08 | 2010-06-02 | 陈全友 | Compounded traditional Chinese medicine for treating chiral and pedal numbness |
-
2010
- 2010-08-26 CN CN2010102636719A patent/CN101972371B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113777A (en) * | 1994-06-20 | 1995-12-27 | 郭昌毕 | Xugu powder for promoting reunion of fractured bones and its producing method |
| CN1116935A (en) * | 1994-07-06 | 1996-02-21 | 郭俊京 | Analgesic plaster |
| CN1161229A (en) * | 1997-01-23 | 1997-10-08 | 陈宝朝 | Traditional Chinese medicine for treating apoplexy and method for preparing same |
| CN1413704A (en) * | 2002-11-19 | 2003-04-30 | 贵州万胜药业有限责任公司 | Huafeng pill |
| CN101716325A (en) * | 2009-12-08 | 2010-06-02 | 陈全友 | Compounded traditional Chinese medicine for treating chiral and pedal numbness |
Non-Patent Citations (3)
| Title |
|---|
| 张道厚等.从肝论治偏头痛体会.《云南中医中药杂志》.2005,第26卷(第1期),53-54. * |
| 项杨等.偏头痛中医药治疗近况.《中医药导报》.2007,第13卷(第4期),104-106. * |
| 顾锡镇.偏头痛证治初探.《中国临床康复》.2002,第6卷(第16期),2452-2453. * |
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