CN101972399B - Medicament for treating hypertension and preparation method thereof - Google Patents
Medicament for treating hypertension and preparation method thereof Download PDFInfo
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- CN101972399B CN101972399B CN2010102636742A CN201010263674A CN101972399B CN 101972399 B CN101972399 B CN 101972399B CN 2010102636742 A CN2010102636742 A CN 2010102636742A CN 201010263674 A CN201010263674 A CN 201010263674A CN 101972399 B CN101972399 B CN 101972399B
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Abstract
The invention discloses a medicament for treating hypertension. The medicament is characterized by mainly comprising the following raw materials in part by weight: 1 to 20 parts of rose, 1 to 20 parts of seville orange flower, 1 to 20 parts of manyflower solomonseal rhizome, 1 to 20 parts of common selfheal fruit-spike, 1 to 20 parts of motherwort herb, 1 to 20 parts of plantain herb and 1 to 20 parts of over 95 percent edible ethanol. The medicament can be orally taken and absorbed by spleen and stomach, can be externally used and absorbed by skin, and can be absorbed compositely in an oral administration mode and an external use mode. The medicament has reasonable formula, simplified compatibility and exact curative effect, treats both principal and secondary aspects of diseases, and can be used for hyperpietic with dizziness, hand numbness and swelling. The invention also provides a preparation method of the medicament.
Description
Technical field
The invention belongs to the field of Chinese medicines, hypertensive medicine of treatment of particularly a kind of oral administration or external and preparation method thereof.
Background technology
Hypertension is that a kind of the rising with body circulation systolic arterial pressure and/or diastolic pressure is the clinical syndrome of feature, and it is one of the most common at present clinical, most important cardiovascular disease.Often with organ dysfunction or organic changes such as fat and sugar metabolism disorder and the heart, brain, kidney and retinas, reinventing with organ is feature.This disease can be by due to multiple pathogenic factors and the complicated pathogenesis, and heredity is secreted in the central nervous system function imbalance in the body fluid, the dysfunction of kidney cerebrovascular pressure receptor, and the cell membrane ion transport is unusual etc. all can cause hypertension.
Along with improving constantly of people's living standard, hypertensive prevalence is also increasing year by year, the hypertensive prevalence of China has risen to 11.68% at present, especially target organ damages such as the heart of hypertension secondary, brain, kidney, have a strong impact on patient's life-span and quality of life, become the disease of serious threat human health and life.
Doctor trained in Western medicine thinks that hypertension is a kind of disease that can not cure, can only lean on enalapril meleate (Western medicine) to keep the stable of blood pressure.But practical situation is the prolongation along with the time, and the state of an illness increases the weight of gradually, and serious meeting causes diseases such as patient's cerebral hemorrhage, cerebral embolism, hemiplegia.
Chinese patent CN200710015375.5 discloses a kind of Chinese medicinal capsule of the person in middle and old age's of treatment essential hypertension, be by the Radix Rehmanniae, Radix Rehmanniae Preparata, Radix Polygoni Multiflori, Fructus Mori, Fructus Ligustri Lucidi, Semen Astragali Complanati, Fructus Tribuli, Herba Cynomorii, Radix Achyranthis Bidentatae, Semen Cuscutae, Semen Raphani, Rhizoma Atractylodis Macrocephalae (parched), Fructus Lycii, Semen Plantaginis, Semen Cassiae, Flos Chrysanthemi, Radix Polygalae (processing), Rhizoma Acori Graminei each, the formulated Chinese medicinal capsule of Herba Asari.Chinese patent CN00112443.9 discloses a kind of Chinese medicine ， that treats hypertension and has been made up of Herba Siegesbeckiae, Radix Gentianae, Spica Prunellae, Herba Apocyni veneti etc., and its preparation method is: take by weighing Chinese medicine, be ground into attritive powder, take for the patient.Chinese patent CN200610165007.4 discloses the hypertensive Chinese medicine oral liquid of a kind of treatment, and it is that raw material is made with Semen Persicae, Radix Platycodonis, Concha Haliotidis, Flos Carthami, Radix Bupleuri, Fructus Gardeniae, Radix Angelicae Sinensis, Fructus Aurantii, Poria cum Radix Pini, Radix Rehmanniae, Radix Glycyrrhizae, Radix Scutellariae, Rhizoma Chuanxiong, Rhizoma Gastrodiae, the Cortex Eucommiae, Radix Paeoniae Rubra, Ramulus Uncariae Cum Uncis, Herba Leonuri, Radix Cyathulae, Semen Cassiae, Herba Taxilli, Caulis Polygoni Multiflori.
The hypertensive Chinese medicine product of above-mentioned treatment is paid attention to regulating too much, and used taste of Chinese medicine number is too much, has reduced the medicine proportion of a therapeutical effect relatively, has influenced the pharmic function performance, so effect is slow, the course of treatment is long, and effect is undesirable; And existing Chinese medicine oral administration but can not external, but can not the taking orally again of external, route of administration is single, makes the patient slow to the absorption of medicine.Chinese medicine for oral administration not only absorbs slowly, and causes spleen injury easily, even increase the weight of the state of an illness for the patient of weakness of the spleen and stomach.
Chinese medicine is taken difficulty owing to mostly be decoction or the pill that boils than Western medicine, has also influenced the popularization of Chinese medicine widely.
Summary of the invention
The objective of the invention is to overcome the defective that prior art exists, a kind of reasonable recipe is provided, compatibility is simplified, the hypertensive medicine of treatment of determined curative effect, treating both the principal and secondary aspects of a disease, to control, control foster combination, and this medicine can take orally by taste absorb again can external by skin absorbs, can also oral administration and externally used dual mode composite absorption.This compound administering mode helps the efficient absorption of human body to medicine, and for the crowd of weakness of the spleen and stomach, the medicine that is busy with one's work, spares oneself provides multiple choices, especially the patient by the modern job crowd is accepted.
Technical scheme of the present invention is as follows:
The hypertensive medicine of a kind of treatment is characterized in that it mainly is to be made by the raw material of following weight portion: 1 ~ 20 part of Flos Rosae Rugosae, 1 ~ 20 part of CitrusaurantiumL.Var.amara Engl., 1 ~ 20 part of Rhizoma Polygonati, 1 ~ 20 part of Spica Prunellae, 1 ~ 20 part of Herba Leonuri, 1 ~ 20 part of Herba Plantaginis, content are 1 ~ 20 part of edible ethanol more than 95%.
Further, the consumption of each component of medicine of the present invention is: 15 ~ 20 parts of Flos Rosae Rugosaes, and 15 ~ 20 parts of CitrusaurantiumL.Var.amara Engl.s, 15 ~ 20 parts of Rhizoma Polygonatis, 15 ~ 20 parts of Spica Prunellaes, 15 ~ 20 parts of Herba Leonuris, 15 ~ 20 parts of Herba Plantaginiss, content is 15 ~ 20 parts of edible ethanols more than 95%.
The middle survival dose of above compatibility is the crude drug amount.
In order to strengthen the transdermal effect of medicine, can also mix transdermal agent in the medicine of the present invention, preferably weight portion is 1 ~ 5 part a azone.
Another object of the present invention provides manufacturing method for above mentioned medicine, it is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Rhizoma Polygonati, Spica Prunellae, Herba Leonuri, the Herba Plantaginis of described weight proportion, according to the conventional extracting method of Chinese medicine, the extract of the former medicine that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds described weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrate sterilization, fill according to quantity must be treated hypertensive medicine.
Further, among the step c, can add in the aqueous solution of alcohol together by azone step a is extract obtained and 1 ~ 5 weight portion.
The conventional extracting method of described Chinese crude drug can adopt decocting method, circumfluence method, infusion process, percolation, semi-bionic extraction, supercritical fluid extraction, microwave extraction method etc. according to the kind of medical material.
Hypertension belongs to traditional Chinese medical science vertiginous disorder, how by the spleen kidney deficiency, due to liver-yang is high partially, for deficiency and excess is held assorted disease under the arm.
The present invention is directed to the hypertensive characteristics of middle-older patient, select Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Rhizoma Polygonati, Spica Prunellae, Herba Leonuri, Herba Plantaginis for use,, make to contain pure Chinese medicine extraction liquid being that edible ethanol more than 95% mixes with content after each flavor Chinese medicine extraction.Employing to be to control, and control and support bonded method, but not only also external of oral administration of the medicine of making is a kind of reasonable recipe, and compatibility is simplified, the hypertensive medicine of treatment of determined curative effect, treating both the principal and secondary aspects of a disease.
Rhizoma Polygonati strengthening the spleen kidney, profit cardiopulmonary in the medicine of the present invention; Spica Prunellae clearing away liver-fire, suppressing the hyperactive liver sun; Herba Leonuri is invigorated blood circulation, the Herba Plantaginis diuretic.All medicines match, can spleen reinforcings, suppressing the hyperactive liver, collateral dredging be with blood pressure lowering, be particularly useful for cerebrovascular sclerosis, nephrotic edema has the hyperpietic concurrently.The few merit work of we's medicine, effect is outstanding.Flos Rosae Rugosae regulate the flow of vital energy resolving depression and blood dissipating blood stasis; The CitrusaurantiumL.Var.amara Engl. the chest stuffiness relieving of regulating the flow of vital energy, dispersing the stagnated liver-QI for regulating the stomach, appetizing preventing or arresting vomiting.Two medicines, 5 usefulness, a gas one blood, QI and blood is two transfers, and the strength of eliminating turbid pathogen with aromatics, be amusing appetizing, regulating QI to relieve pain strengthens.Content is the edible ethanol blood circulation promoting and blood stasis dispelling more than 95%, promotes that drug osmotic to cell absorbs.
Medicine of the present invention can also be smeared by whole body except for oral administration.Adopt oral administration and externally usedly, drug effect is more remarkable.
It is obvious that the present invention treats the hypertension curative effect, and short treating period can be used for dizzy, numbness of hand, swelling has the hyperpietic concurrently.Clinical usefulness repeatly, effect are very prompt.
Medicine of the present invention is through clinical 80 routine patients' clinical verification, and curing number is 48 examples, and significant figure is 24 examples, and invalid number is 8 examples, and total effective rate reaches 90%.Do not see toxic side effect in the therapeutic process, the patient has better curative effect to obstinate.
For further specifying therapeutic effect, it is as follows now to enumerate model case:
Case 1: certain man, 60 years old, suffer from vascular hypertension for many years, blood pressure is kept blood pressure by taking Western medicine up to 170/103mmHg always, often tinnitus, dizzy, headache, nauseating, vomiting, shortness of breath and palpitation, insomnia.Oral medicine of the present invention, each 10 milliliters, every day 3 times, above disease was alleviated in 10 days, and blood pressure was reduced to 150/95mmHg in 30 days.Pay a return visit blood pressure after 6 months and reduce to normal value.
Case 2: certain man, 55 years old, suffer from vascular hypertension for many years, blood pressure is up to 148/96mmHg.Do not use before this medicine with symptoms such as tinnitus, dizzy, headache, shortness of breath and palpitation, insomnias.External medicine of the present invention is smeared whole body and head, and every day 2 times, each 10 milliliters, above disease was alleviated in 7 days, and blood pressure was reduced to 135/88mmHg in 30 days, belonged to normal range.Paying a return visit after 6 months does not have recurrence.
Case 3: certain woman, 58 years old, suffer from vascular hypertension for many years, blood pressure was once taken the Chinese medicine of a variety of blood pressure lowering up to 178/106mmHg, but effect is all not good, and did not use before this medicine also with symptoms such as tinnitus, dizzy, headache, shortness of breath and palpitation, insomnias.Oral medicine of the present invention, each 10 milliliters, every day 3 times; This medicine of external is smeared whole body and head, every day 2 times, each 10 milliliters.Above disease 5 days is alleviated, and reduces to 155/98mmHg in 30 days.Pay a return visit blood pressure after 8 months and reduce to normal value.
The specific embodiment
Embodiment 1
Take by weighing 15 parts of Flos Rosae Rugosaes, 15 parts of CitrusaurantiumL.Var.amara Engl.s, 16 parts of Rhizoma Polygonatis, 16 parts of Spica Prunellaes, 16 parts of Herba Leonuris, 16 parts of Herba Plantaginiss adopt the method that decocts the back concentrating under reduced pressure to make Chinese medicine extract respectively, and are standby.
Under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add content and be 18 parts of 96% edible ethanols, be mixed with aqueous solution of alcohol, standby.
Above-mentioned various Chinese medicine extract are added in the aqueous solution of alcohol, fully stirred 120 minutes, precipitate 2 ~ 4 hours, supernatant 200 orders filter, and the hypertensive medicine of treatment that gained filtrate is oral administration or external carries out fill under aseptic condition.Gained precipitate and filtering residue focus on.
Embodiment 2
The drug component proportioning is: 18 parts of Flos Rosae Rugosaes, and 19 parts of CitrusaurantiumL.Var.amara Engl.s, 17 parts of Rhizoma Polygonatis, 17 parts of Spica Prunellaes, 17 parts of Herba Leonuris, 17 parts of Herba Plantaginiss, content is 18 parts of 97% edible ethanols.Other is identical with embodiment 1.
Embodiment 3
The drug component proportioning is: 19 parts of Flos Rosae Rugosaes, and 20 parts of CitrusaurantiumL.Var.amara Engl.s, 19 parts of Rhizoma Polygonatis, 19 parts of Spica Prunellaes, 19 parts of Herba Leonuris, 19 parts of Herba Plantaginiss, content is 18 parts of 98% edible ethanols.Other is identical with embodiment 1.
Embodiment 4
The drug component proportioning is: 16 parts of Flos Rosae Rugosaes, and 29 parts of CitrusaurantiumL.Var.amara Engl.s, 18 parts of Rhizoma Polygonatis, 16 parts of Spica Prunellaes, 18 parts of Herba Leonuris, 17 parts of Herba Plantaginiss, content is 17 parts of 99% edible ethanols.Other is identical with embodiment 1.
Embodiment 5
The drug component proportioning is: 19 parts of Flos Rosae Rugosaes, and 19 parts of CitrusaurantiumL.Var.amara Engl.s, 18 parts of Rhizoma Polygonatis, 17 parts of Spica Prunellaes, 19 parts of Herba Leonuris, 18 parts of Herba Plantaginiss, content is 20 parts of 100% edible ethanols.Other is identical with embodiment 1.
Embodiment 6
The drug component proportioning is: 16 parts of Flos Rosae Rugosaes, and 17 parts of CitrusaurantiumL.Var.amara Engl.s, 18 parts of Rhizoma Polygonatis, 17 parts of Spica Prunellaes, 18 parts of Herba Leonuris, 18 parts of Herba Plantaginiss, content is 17 parts of 98% edible ethanols.Other is identical with embodiment 1.
Claims (5)
1. the hypertensive medicine of treatment is characterized in that it is to be made by the raw material of following weight portion: 1 ~ 20 part of Flos Rosae Rugosae, 1 ~ 20 part of CitrusaurantiumL.Var.amara Engl., 1 ~ 20 part of Rhizoma Polygonati, 1 ~ 20 part of Spica Prunellae, 1 ~ 20 part of Herba Leonuri, 1 ~ 20 part of Herba Plantaginis, content are 1 ~ 20 part of edible ethanol more than 95%.
2. medicine as claimed in claim 1 is characterized in that it is to be made by the raw material of following weight portion: 15 ~ 20 parts of Flos Rosae Rugosaes, 15 ~ 20 parts of CitrusaurantiumL.Var.amara Engl.s, 15 ~ 20 parts of Rhizoma Polygonatis, 15 ~ 20 parts of Spica Prunellaes, 15 ~ 20 parts of Herba Leonuris, 15 ~ 20 parts of Herba Plantaginiss, content are 15 ~ 20 parts of edible ethanols more than 95%.
3. medicine as claimed in claim 1 or 2 is characterized in that, further contains weight portion and be 1 ~ 5 part azone on the basis of claim 1 or 2 described medicines.
4. the preparation method of claim 1 or 2 described medicines is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Rhizoma Polygonati, Spica Prunellae, Herba Leonuri, the Herba Plantaginis of described weight proportion, according to the conventional extracting method of Chinese medicine, the extract of the raw material that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds described weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrate sterilization, fill according to quantity must be treated hypertensive medicine.
5. the preparation method of the described medicine of claim 3 is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Rhizoma Polygonati, Spica Prunellae, Herba Leonuri, the Herba Plantaginis of described weight proportion, according to the conventional extracting method of Chinese medicine, the extract of the raw material that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds described weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) azone step a is extract obtained and described weight proportion adds in the aqueous solution of alcohol together, stirs 120 minutes, precipitates 2 ~ 4 hours, filter, and gained filtrate sterilization, fill according to quantity must be treated hypertensive medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102636742A CN101972399B (en) | 2010-08-26 | 2010-08-26 | Medicament for treating hypertension and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102636742A CN101972399B (en) | 2010-08-26 | 2010-08-26 | Medicament for treating hypertension and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101972399A CN101972399A (en) | 2011-02-16 |
| CN101972399B true CN101972399B (en) | 2011-10-12 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1248711C (en) * | 2004-01-11 | 2006-04-05 | 胡克华 | Chinese herbal medicine for treating hypertension |
| CN101601811A (en) * | 2008-06-13 | 2009-12-16 | 韩庆亮 | A kind of Chinese drugs agentia for the treatment of hypertension |
| CN101401910A (en) * | 2008-09-23 | 2009-04-08 | 罗先德 | Medicament for treating hypertension |
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Granted publication date: 20111012 Termination date: 20180826 |