CN101983693B - Drug for treating alopecia and preparation method thereof - Google Patents
Drug for treating alopecia and preparation method thereof Download PDFInfo
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- CN101983693B CN101983693B CN201010263743XA CN201010263743A CN101983693B CN 101983693 B CN101983693 B CN 101983693B CN 201010263743X A CN201010263743X A CN 201010263743XA CN 201010263743 A CN201010263743 A CN 201010263743A CN 101983693 B CN101983693 B CN 101983693B
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Abstract
The invention discloses a drug for treating alopecia, which is characterized by being mainly prepared from the following raw materials by weight: 1-20 parts of roses, 1-20 parts of seville orange flowers, 1-20 parts of radix rehmanniae rreparata, 1-20 parts of angelica, 1-20 parts of radix paeoniae alba, 1-20 parts of rhizoma Chuanxiong, 1-20 parts of papaya, 1-20 parts of dodder, 1-20 parts of peach kernels, 1-20 parts of tuber fleeceflower root, 1-20 parts of black sesame, 1-20 parts of mulberry leaves, 1-20 parts of rhizoma gastrodiae, 1-20 parts of notopterygium incisum, 1-20 parts of safflowers and 1-20 parts of edible alcohol with content being more than 95%. The drug can be absorbed by the spleens and stomachs internally or absorbed by skins externally or absorbed internally and externally. The drug has reasonable components, simple compatibility and confirmed curative effect and treats both principal and secondary aspects of the diseases. The invention also provides a preparation method of the drug.
Description
Technical field
The invention belongs to the field of Chinese medicines, medicine of the treatment alopecia of particularly a kind of oral administration or external and preparation method thereof.
Background technology
The cause of disease of alopecia is many and complicated, but modal be seborrheic alopecia.The alopecia reason is a hypersteatosis, and the suppurative mastitis head stops up, and the part is inflamed and causes, maybe with vitamin deficiency, factors such as lipodystrophy, direct stimulation are relevant.The seborrheic alopecia pilosity is born in front and calvarium portion, and it is sparse to show as the hair uniformity, and desquamation and pruritus are in various degree often arranged.
Motherland's Chinese medicine is thought the cause of disease of alopecia mainly at kidney, if Liver and kidney two empty insufficiency of vital energy and bloods, the blood circulation of whole body is just weak; Unable nutrient substance is transported to the axial highest point of human body " crown "; Hair follicle can not get nourishing on the head, and atrophy gradually will cause alopecia." kidney storing essence, main reproduction, its Hua Zaifa ", " hair is the sign of blood condition " think that the kidney being the origin of congenital constitution, and hair is the product of blood.Kidney storing essence, blood stored in the liver, essence and blood sharing the same origin transforms each other, and both are indispensable.
Chinese patent CN200510042231.X discloses a kind of Chinese medicine for outer use of treating alopecia, and the raw material of processing this pharmaceutically active ingredient consists of: Radix Polygoni Multiflori, and Radix Rehmanniae Preparata, Rhizoma Zingiberis Recens, Cacumen Platycladi, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii, Borneolum Syntheticum is with processing liniment after the various medical material decocting and concentrating.Chinese patent CN200410040153.5 discloses a kind of Chinese medicine pill of treating alopecia and preparation method thereof.Each composition and effectiveness of this Chinese medicine pill is: the Radix Rehmanniae, Cortex Moutan, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, the Radix Polygoni Multiflori, Fructus Mori, Semen sesami Niger, windproof, according to the method for preparing of preparation, process Chinese medicine pill.Chinese patent CN200510033264.8 discloses a kind of Chinese medicine composition of treating alopecia and preparation method thereof; By Radix Rehmanniae, Radix Rehmanniae Preparata, Radix Polygoni Multiflori Preparata, Radix Salviae Miltiorrhizae, Radix Paeoniae Alba (parched), Fructus Chaenomelis, the volatile oil clathrate compound of Radix Angelicae Sinensis, Fructus Schisandrae Chinensis, Rhizoma Et Radix Notopterygii adds adjuvant with water extract and processes tablet or load into capsule.
The Chinese medicine product of above-mentioned treatment alopecia is too much paid attention to regulating, and has reduced the medicine proportion of a therapeutical effect relatively, has influenced the pharmic function performance, so effect is slow, the course of treatment is long, and effect is undesirable; And existing Chinese medicine oral administration but can not external, but can not the taking orally again of external, route of administration is single, makes the patient slow to the absorption of medicine.Chinese medicine for oral administration not only absorbs slowly, and causes spleen injury easily, even increase the weight of the state of an illness for the patient of weakness of the spleen and stomach.
Chinese medicine is taken difficulty owing to the decoction or the pill that are mostly to boil than Western medicine, has also influenced the popularization of Chinese medicine widely.
Summary of the invention
The objective of the invention is to overcome the defective that prior art exists; A kind of reasonable recipe is provided; Compatibility is simplified, the medicine of the treatment alopecia of determined curative effect, treating both the principal and secondary aspects of a disease, is main to control, and controls to support to combine; And this medicine can take orally through taste absorb again can external through skin absorbs, can also oral administration and externally used dual mode composite absorbent.This compound administering mode helps the efficient absorption of human body to medicine, and for the crowd of weakness of the spleen and stomach, the medicine that is busy with one's work, spares oneself provides multiple choices, especially the patient by the modern job crowd is accepted.
Technical scheme of the present invention is following:
A kind of medicine of treating alopecia is characterized in that it mainly is to be processed by the raw material of following weight portion: 1 ~ 20 part of Flos Rosae Rugosae, 1 ~ 20 part of CitrusaurantiumL.Var.amara Engl., 1 ~ 20 part in Radix Rehmanniae Preparata, 1 ~ 20 part of Radix Angelicae Sinensis; 1 ~ 20 part of Radix Paeoniae Alba, 1 ~ 20 part of Rhizoma Chuanxiong, 1 ~ 20 part of Fructus Chaenomelis, 1 ~ 20 part of Semen Cuscutae; 1 ~ 20 part in Semen Persicae, 1 ~ 20 part of Radix Polygoni Multiflori, 1 ~ 20 part of Semen Sesami Nigrum, 1 ~ 20 part on Folium Mori; 1 ~ 20 part in Rhizoma Gastrodiae, 1 ~ 20 part of Rhizoma Et Radix Notopterygii, 1 ~ 20 part on Flos Carthami, content are 1 ~ 20 part of edible ethanol more than 95%.
Further, the consumption of each component of medicine of the present invention is: 15 ~ 20 parts of Flos Rosae Rugosaes, 15 ~ 20 parts of CitrusaurantiumL.Var.amara Engl.s, 15 ~ 20 parts in Radix Rehmanniae Preparata, 15 ~ 20 parts of Radix Angelicae Sinensis; 15 ~ 20 parts of Radix Paeoniae Alba, 15 ~ 20 parts of Rhizoma Chuanxiongs, 15 ~ 20 parts of Fructus Chaenomeliss, 15 ~ 20 parts of Semen Cuscutae; 15 ~ 20 parts in Semen Persicae, 15 ~ 20 parts of Radix Polygoni Multiflori, 15 ~ 20 parts of Semen Sesami Nigrums, 15 ~ 20 parts on Folium Mori; 15 ~ 20 parts in Rhizoma Gastrodiae, 15 ~ 20 parts of Rhizoma Et Radix Notopterygiis, 15 ~ 20 parts on Flos Carthami, content are 15 ~ 20 parts of edible ethanols more than 95%.
The middle survival dose of above compatibility is the crude drug amount.
In order to strengthen the transdermal effect of medicine, can also mix transdermal agent in the medicine of the present invention, preferably weight portion is 1 ~ 5 part a azone.
Another object of the present invention provides manufacturing method for above mentioned medicine, it is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Chuanxiong, Fructus Chaenomelis, Semen Cuscutae, Semen Persicae, Radix Polygoni Multiflori, Semen Sesami Nigrum, Folium Mori, Rhizoma Gastrodiae, the Rhizoma Et Radix Notopterygii and Flos Carthami of said weight proportion; According to the conventional method for distilling of Chinese medicine, the extract of the former medicine that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds said weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrating sterilization, fill according to quantity must be treated the medicine of alopecia.
Further, among the step c, can add in the aqueous solution of alcohol together by azone step a is extract obtained and 1 ~ 5 weight portion.
The conventional method for distilling of said Chinese crude drug can adopt decocting method, circumfluence method, infusion process, percolation, semi-bionic extraction, supercritical fluid extraction, microwave extraction method etc. according to the kind of medical material.
The present invention is directed to the characteristics of pathologic alopecia; Select Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Chuanxiong, Fructus Chaenomelis, Semen Cuscutae, Semen Persicae, Radix Polygoni Multiflori, Semen Sesami Nigrum, Folium Mori, Rhizoma Gastrodiae, Rhizoma Et Radix Notopterygii, Flos Carthami for use; With being that edible ethanol more than 95% mixes with content after each flavor Chinese medicine extraction, process to contain pure Chinese medicine extraction liquid.Employing is main to control, and control the bonded method of supporting, but not only also external of oral administration of the medicine of processing is a kind of reasonable recipe, and compatibility is simplified, the medicine of the treatment alopecia of determined curative effect, treating both the principal and secondary aspects of a disease.
Radix Rehmanniae Preparata nourishing the blood and yin, vital essence replenishing and marrow benifiting.Chinese angelica blood supplementing and blood.The Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.The Rhizoma Chuanxiong activating QI to alleviate the depression, the method wind-dryness is wet, promoting blood circulation and stopping pain.The Fructus Chaenomelis suppressing the hyperactive liver and easing the stomach, Shujin dries.The Semen Cuscutae invigorating the liver and kidney, beneficial marrow.The Semen Persicae blood stasis removing and clots absorbing is moisturized laxation.The Radix Polygoni Multiflori tonifying liver, kidney tonifying nourishes blood, and dispels the wind.The Semen Sesami Nigrum invigorating the liver and kidney of nourishing blood.The Folium Mori expelling wind and clearing away heat, cooling blood for improving eyesight.The Rhizoma Gastrodiae endogenous wind stopping, arresting convulsion.The Rhizoma Et Radix Notopterygii cold expelling dispels the wind, dehumidifying.The Flos Carthami promoting blood circulation to restore menstrual flow.
Hair is the sign of blood condition, the Hua Zaifa of kidney.That sends out is flourishing and withering, relies moistening of blood foster entirely, the filling of kidney.Though exopathogenic factor wind is contained dry blood, main for kidney qi not flourish due to send out.The present invention nourishes blood with SIWU TANG (Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong).Blood is contained then and is taken place, with hair is the sign of blood condition also.Radix Rehmanniae Preparata, Semen Cuscutae, Radix Polygoni Multiflori, mulberry hemp pill (Folium Mori, Semen Sesami Nigrum) nourishing the liver and kidney, Liver and kidney gas fill then sends out high honour and black profit.The Fructus Chaenomelis nourishing the liver is with yin fluid astringing; Blood stored in the liver, nourishing the liver can be nourished blood, and Rhizoma Gastrodiae nourishes blood, and relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and Rhizoma Et Radix Notopterygii nature and flavor hero is strong, top, through mountain peak, in order to dredge the blood vessels on top, mountain peak, then hair is prone to give birth to; Semen Persicae, Flos Carthami blood circulation promoting and blood stasis dispelling, the stasis of blood do not go then newly not give birth to, so blood stasis dispelling is a tissue regeneration promoting.Flos Rosae Rugosae regulate the flow of vital energy resolving depression and blood dissipating blood stasis; The CitrusaurantiumL.Var.amara Engl. the chest stuffiness relieving of regulating the flow of vital energy, dispersing the stagnated liver-QI for regulating the stomach, appetizing preventing or arresting vomiting.Two medicines, 5 usefulness, a gas one blood, QI and blood is two to be transferred, and the strength of eliminating turbid pathogen with aromatics, be amusing appetizing, regulating QI to relieve pain strengthens.Content is the edible ethanol blood circulation promoting and blood stasis dispelling more than 95%, promotes that drug osmotic to cell absorbs.
Medicine of the present invention can be smeared the affected part with medicine of the present invention except for oral administration, and the efficacy of a drug sick institute that goes directly so can remove the patient suffering, obtains and imitates in no time.This medicine is applicable to that also whole body smears.Adopt oral administration and externally usedly, drug effect is more remarkable.
It is obvious that the present invention treats the alopecia curative effect, and short treating period can be used for pathologic alopecias such as seborrheic alopecia, alopecia areata.
Medicine of the present invention is through clinical 120 routine patients' clinical verification, and curing number is 93 examples, and significant figure is 19 examples, and invalid number is 8 examples, and total effective rate reaches 93.3%.Do not see toxic side effect in the therapeutic process, the patient has better curative effect to obstinate.
For further specifying therapeutic effect, to enumerate model case following at present:
Case 1: certain woman, 27 years old, hair was uninteresting, come off easily and fracture, and the hair washing alopecia is serious, and the amount of sending out reduces.Once took the Chinese medicine of a variety of treatment alopecias, but effect is all not good.Oral medicine of the present invention, each 10 milliliters, every day 3 times.Alopecia reduces after 10 days, and hair is glossy.Adhered to taking 30 days.Pay a return visit no abnormal alopecia after 6 months, root of hair is firm.
Case 2: certain woman, 36 years old, hair density was gradually low, uninteresting, easy alopecia during combing.Once took the Chinese medicine of a variety of treatment alopecias, but effect is all not good.These article of external are smeared whole body and head, and every day 2 times, each 10 milliliters, head is repeatedly smeared.External is condition improved after 7 days, the moist easy combing of hair.Adhered to external 30 days.It is more pitch-black dense to pay a return visit hair after 8 months, and root of hair is firm.
Case 3: certain man, 48 years old, crown alopecia was serious, was commonly called as " Mediterranean ".Once took the Chinese medicine of a variety of treatment alopecias, but effect is all not good.Oral medicine of the present invention, each 10 milliliters, every day 3 times; This medicine of external is smeared whole body and head, every day 2 times, each 10 milliliters.Adhere to oral and external 30 days, the crown is piliation gradually.Pay a return visit crown hair after 9 months and become changeable black.
The specific embodiment
Embodiment 1
Take by weighing 15 parts of Flos Rosae Rugosaes, 18 parts of CitrusaurantiumL.Var.amara Engl.s, 16 parts in Radix Rehmanniae Preparata, 16 parts of Radix Angelicae Sinensis, 16 parts of Radix Paeoniae Alba; 16 parts of Rhizoma Chuanxiongs, 17 parts of Fructus Chaenomeliss, 16 parts of Semen Cuscutae, 16 parts in Semen Persicae; 17 parts of Radix Polygoni Multiflori, 16 parts of Semen Sesami Nigrums, 16 parts on Folium Mori, 17 parts in Rhizoma Gastrodiae; 18 parts of Rhizoma Et Radix Notopterygiis, 16 parts on Flos Carthami adopts the method that decocts the back concentrating under reduced pressure to process Chinese medicine extract respectively, and is subsequent use.
Under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add content and be 18 parts of 96% edible ethanols, be mixed with aqueous solution of alcohol, subsequent use.
Above-mentioned various Chinese medicine extract are added in the aqueous solution of alcohol, fully stirred 120 minutes, precipitate 2 ~ 4 hours, supernatant 200 orders filter, and the medicine that gained filtrating is the treatment alopecia of oral administration or external carries out fill under aseptic condition.Gained precipitate and filtering residue focus on.
Embodiment 2
The drug component proportioning is: 18 parts of Flos Rosae Rugosaes, 19 parts of CitrusaurantiumL.Var.amara Engl.s, 17 parts in Radix Rehmanniae Preparata, 17 parts of Radix Angelicae Sinensis; 17 parts of Radix Paeoniae Alba, 17 parts of Rhizoma Chuanxiongs, 18 parts of Fructus Chaenomeliss, 17 parts of Semen Cuscutae; 17 parts in Semen Persicae, 18 parts of Radix Polygoni Multiflori, 17 parts of Semen Sesami Nigrums, 17 parts on Folium Mori; 18 parts in Rhizoma Gastrodiae, 19 parts of Rhizoma Et Radix Notopterygiis, 17 parts on Flos Carthami, content are 18 parts of 97% edible ethanols.Other is identical with embodiment 1.
Embodiment 3
The drug component proportioning is: 19 parts of Flos Rosae Rugosaes, 20 parts of CitrusaurantiumL.Var.amara Engl.s, 18 parts in Radix Rehmanniae Preparata, 18 parts of Radix Angelicae Sinensis; 18 parts of Radix Paeoniae Alba, 18 parts of Rhizoma Chuanxiongs, 19 parts of Fructus Chaenomeliss, 18 parts of Semen Cuscutae; 18 parts in Semen Persicae, 19 parts of Radix Polygoni Multiflori, 18 parts of Semen Sesami Nigrums, 18 parts on Folium Mori; 19 parts in Rhizoma Gastrodiae, 20 parts of Rhizoma Et Radix Notopterygiis, 19 parts on Flos Carthami, content are 18 parts of 98% edible ethanols.Other is identical with embodiment 1.
Embodiment 4
The drug component proportioning is: 15 parts of Flos Rosae Rugosaes, 16 parts of CitrusaurantiumL.Var.amara Engl.s, 17 parts in Radix Rehmanniae Preparata, 19 parts of Radix Angelicae Sinensis; 16 parts of Radix Paeoniae Alba, 19 parts of Rhizoma Chuanxiongs, 17 parts of Fructus Chaenomeliss, 16 parts of Semen Cuscutae; 19 parts in Semen Persicae, 20 parts of Radix Polygoni Multiflori, 19 parts of Semen Sesami Nigrums, 17 parts on Folium Mori; 18 parts in Rhizoma Gastrodiae, 19 parts of Rhizoma Et Radix Notopterygiis, 18 parts on Flos Carthami, content are 20 parts of 99% edible ethanols.Other is identical with embodiment 1.
Embodiment 5
The drug component proportioning is: 16 parts of Flos Rosae Rugosaes, 18 parts of CitrusaurantiumL.Var.amara Engl.s, 19 parts in Radix Rehmanniae Preparata, 17 parts of Radix Angelicae Sinensis; 19 parts of Radix Paeoniae Alba, 16 parts of Rhizoma Chuanxiongs, 16 parts of Fructus Chaenomeliss, 19 parts of Semen Cuscutae; 19 parts in Semen Persicae, 20 parts of Radix Polygoni Multiflori, 17 parts of Semen Sesami Nigrums, 19 parts on Folium Mori; 16 parts in Rhizoma Gastrodiae, 18 parts of Rhizoma Et Radix Notopterygiis, 18 parts on Flos Carthami, content are 19 parts of 100% edible ethanols.Other is identical with embodiment 1.
Embodiment 6
The drug component proportioning is: 19 parts of Flos Rosae Rugosaes, 18 parts of CitrusaurantiumL.Var.amara Engl.s, 19 parts in Radix Rehmanniae Preparata, 16 parts of Radix Angelicae Sinensis; 19 parts of Radix Paeoniae Alba, 15 parts of Rhizoma Chuanxiongs, 18 parts of Fructus Chaenomeliss, 19 parts of Semen Cuscutae; 17 parts in Semen Persicae, 18 parts of Radix Polygoni Multiflori, 19 parts of Semen Sesami Nigrums, 19 parts on Folium Mori; 18 parts in Rhizoma Gastrodiae, 17 parts of Rhizoma Et Radix Notopterygiis, 18 parts on Flos Carthami, content are 18 parts of 97% edible ethanols.Other is identical with embodiment 1.
Claims (1)
1. medicine of treating alopecia is characterized in that being processed by following method:
(1) takes by weighing 15 parts of Flos Rosae Rugosaes, 18 parts of CitrusaurantiumL.Var.amara Engl.s, 16 parts in Radix Rehmanniae Preparata, 16 parts of Radix Angelicae Sinensis, 16 parts of Radix Paeoniae Alba; 16 parts of Rhizoma Chuanxiongs, 17 parts of Fructus Chaenomeliss, 16 parts of Semen Cuscutae, 16 parts in Semen Persicae; 17 parts of Radix Polygoni Multiflori, 16 parts of Semen Sesami Nigrums, 16 parts on Folium Mori, 17 parts in Rhizoma Gastrodiae; 18 parts of Rhizoma Et Radix Notopterygiis, 16 parts on Flos Carthami adopts the method that decocts the back concentrating under reduced pressure to process Chinese medicine extract respectively, and is subsequent use;
(2) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add content and be 18 parts of 96% edible ethanols, be mixed with aqueous solution of alcohol, subsequent use;
(3) above-mentioned various Chinese medicine extract are added in the aqueous solution of alcohol, fully stirred 120 minutes, precipitate 2 ~ 4 hours, supernatant 200 orders filter, and the medicine that gained filtrating is the treatment alopecia of for oral administration or external carries out fill under aseptic condition.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010263743XA CN101983693B (en) | 2010-08-26 | 2010-08-26 | Drug for treating alopecia and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010263743XA CN101983693B (en) | 2010-08-26 | 2010-08-26 | Drug for treating alopecia and preparation method thereof |
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| CN101983693B true CN101983693B (en) | 2012-06-13 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895532B (en) * | 2012-09-29 | 2014-05-14 | 蒋金洲 | Traditional Chinese medicine composition for treating alopecia areata |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102258700B (en) * | 2011-08-30 | 2015-01-21 | 时秀燕 | Traditional Chinese medicine for treating alopecia and premature graying of hair, and preparation method thereof |
| CN102755364B (en) * | 2012-06-24 | 2014-03-26 | 宁波市鄞州奥胜生物科技有限公司 | External liquid for preventing phalacrosis |
| CN104606104A (en) * | 2015-02-06 | 2015-05-13 | 苏州市天灵中药饮片有限公司 | Composite traditional Chinese medicine extract for hair care and preparation method thereof |
| CN104940530A (en) * | 2015-07-16 | 2015-09-30 | 郭飞勇 | External preparation for treating alopecia and preparing method thereof |
| CN106139029A (en) * | 2016-08-17 | 2016-11-23 | 刘传新 | A kind of Chinese medicine composition treating seborrheic alopecia |
| CN110664943A (en) * | 2019-11-25 | 2020-01-10 | 华夏五谷生物股份有限公司 | Scalp nutrition alopecia prevention and hair growth medicine and preparation method thereof |
| CN110974748A (en) * | 2019-12-27 | 2020-04-10 | 郑永柳 | Hair nourishing liquid and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895532B (en) * | 2012-09-29 | 2014-05-14 | 蒋金洲 | Traditional Chinese medicine composition for treating alopecia areata |
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