CN101972446B - Medicament for treating coronary disease and preparation method thereof - Google Patents
Medicament for treating coronary disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicament for treating coronary disease. The medicament is prepared from the following raw materials in parts by weight: 1-20 parts of rose, 1-20 parts of Seville orange flower, 1-20 parts of white ginseng, 1-20 parts of pseudo-ginseng, 1-20 parts of monkshood, 1-20 parts of tulip, 1-20 parts of hawthorn, 1-20 parts of trogopterus dung, 1-20 parts of cinnamon, 1-20 parts of dalbergia wood, 1-20 parts of frankincense, 1-20 parts of prepared licorice roots and 1-20 parts of more than 95% edible alcohol. The medicament not only can be absorbed through the spleen and the stomach by oral administration, but also can be absorbed through the skin by external use, and can also be compositely absorbed by the two modes of oral administration and external use. The medicament has the advantages of reasonable formulation, simple compatibility and confirmed curative effect, and is used for treating both principal and secondary aspects of disease. The invention also provides a preparation method of the medicament.
Description
Technical field
The invention belongs to the field of Chinese medicines, medicine of the treatment coronary heart disease of particularly a kind of oral administration or external and preparation method thereof.
Background technology
Coronary heart disease is the abbreviation of coronary atherosclerotic heart disease, being meant the blood vessel of supplying with the heart nutrient substance---serious atherosis or spasm takes place in coronary artery, make coronary stricture or obstruction, and thrombosis causes obliteration, cause a kind of heart disease of myocardial ischemia-anoxemia or infraction, also claim ischemic heart desease.Coronary heart disease is the common type that atherosclerosis causes organ lesion, also is the commonly encountered diseases of harm middle-aged and elderly people health.The primary disease cause of disease is unclear fully as yet so far, but think with hypertension, hyperlipemia, high blood viscosity, diabetes endocrine function lowly and factor such as older relevant.
Chinese patent CN200610075100.6 discloses a kind of Chinese medicine preparation that is used for the treatment of angina pectoris and preparation method thereof, it mainly is prepared from by stem and leaf of Radix Ginseng saponin, the Radix Paeoniae Alba, is that edible ethanol more than 95% extracts with the Radix Paeoniae Alba with content, adds stem and leaf of Radix Ginseng saponin behind the purification by macroporous resin and makes drop pill.Chinese patent CN200610072433.3 discloses a kind of Chinese medicine composition of new treatment angina pectoris, this medicine is by making with crude drug: Radix Notoginseng, Radix Codonopsis, Pheretima, Rhizoma Corydalis (processed with vinegar), Semen Lepidii (Semen Descurainiae) (stir-fry), Bulbus Allii Macrostemonis, Cortex Cinnamomi, Mentholum and Borneolum Syntheticum, can be prepared into any suitable clinically oral formulations according to Chinese medicine conventional formulation method, be preferably oral liquid.Chinese patent CN200410072927.2 discloses a kind of Chinese medicine dripping pills for the treatment of angina pectoris, and it is that crude drug is made with Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong and Borneolum Syntheticum.
The Chinese medicine product of above-mentioned treatment coronary heart disease is paid attention to regulating too much, has reduced the medicine proportion of a therapeutical effect relatively, has influenced the pharmic function performance, so effect is slow, the course of treatment is long, and effect is undesirable; And existing Chinese medicine oral administration but can not external, but can not the taking orally again of external, route of administration is single, makes the patient slow to the absorption of medicine.Chinese medicine for oral administration not only absorbs slowly, and causes spleen injury easily, even increase the weight of the state of an illness for the patient of weakness of the spleen and stomach.
Chinese medicine is taken difficulty owing to mostly be decoction or the pill that boils than Western medicine, has also influenced the popularization of Chinese medicine widely.
Summary of the invention
The objective of the invention is to overcome the defective that prior art exists, a kind of reasonable recipe is provided, compatibility is simplified, the medicine of the treatment coronary heart disease of determined curative effect, treating both the principal and secondary aspects of a disease, to control, control foster combination, and this medicine can take orally by taste absorb again can external by skin absorbs, can also oral administration and externally used dual mode composite absorption.This compound administering mode helps the efficient absorption of human body to medicine, and for the crowd of weakness of the spleen and stomach, the medicine that is busy with one's work, spares oneself provides multiple choices, especially the patient by the modern job crowd is accepted.
Technical scheme of the present invention is as follows:
A kind of medicine for the treatment of coronary heart disease is characterized in that it mainly is to be made by the raw material of following weight portion: 1 ~ 20 part of Flos Rosae Rugosae, 1 ~ 20 part of CitrusaurantiumL.Var.amara Engl., 1 ~ 20 part of Radix Ginseng, 1 ~ 20 part of Radix Notoginseng, 1 ~ 20 part of Radix Aconiti Lateralis Preparata, 1 ~ 20 part of Radix Curcumae, 1 ~ 20 part of Fructus Crataegi, 1 ~ 20 part of Oletum Trogopterori, 1 ~ 20 part of Cortex Cinnamomi, 1 ~ 20 part of Lignum Dalbergiae Odoriferae, 1 ~ 20 part of Olibanum, 1 ~ 20 part of Radix Glycyrrhizae Preparata, content are 1 ~ 20 part of edible ethanol more than 95%.
Further, the consumption of each component of medicine of the present invention is: 15 ~ 20 parts of Flos Rosae Rugosaes, 15 ~ 20 parts of CitrusaurantiumL.Var.amara Engl.s, 15 ~ 20 parts of Radix Ginsengs, 15 ~ 20 parts of Radix Notoginseng, 4 ~ 8 parts of Radix Aconiti Lateralis Preparatas, 15 ~ 20 parts of Radix Curcumaes, 15 ~ 20 parts of Fructus Crataegis, 15 ~ 20 parts of Oletum Trogopteroris, 15 ~ 20 parts of Cortex Cinnamomis, 15 ~ 20 parts of Lignum Dalbergiae Odoriferaes, 15 ~ 20 parts of Olibanums, 15 ~ 20 parts of Radix Glycyrrhizae Preparatas, content are 15 ~ 20 parts of edible ethanols more than 95%.
The middle survival dose of above compatibility is the crude drug amount.
In order to strengthen the transdermal effect of medicine, can also mix transdermal agent in the medicine of the present invention, preferably weight portion is 1 ~ 5 part a azone.
Another object of the present invention provides manufacturing method for above mentioned medicine, it is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Radix Ginseng, Radix Notoginseng, Radix Aconiti Lateralis Preparata, Radix Curcumae, Fructus Crataegi, Oletum Trogopterori, Cortex Cinnamomi, Lignum Dalbergiae Odoriferae, Olibanum and the Radix Glycyrrhizae Preparata of described weight proportion, according to the conventional extracting method of Chinese medicine, the extract of the former medicine that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds described weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrate sterilization, fill according to quantity must be treated the medicine of coronary heart disease.
Further, among the step c, can add in the aqueous solution of alcohol together by azone step a is extract obtained and 1 ~ 5 weight portion.
The conventional extracting method of described Chinese crude drug can adopt decocting method, circumfluence method, infusion process, percolation, semi-bionic extraction, supercritical fluid extraction, microwave extraction method etc. according to the kind of medical material.
The present invention is directed to the characteristics of coronary heart disease, select Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Radix Ginseng, Radix Notoginseng, Radix Aconiti Lateralis Preparata, Radix Curcumae, Fructus Crataegi, Oletum Trogopterori, Cortex Cinnamomi, Lignum Dalbergiae Odoriferae, Olibanum, Radix Glycyrrhizae Preparata for use, with being that edible ethanol more than 95% mixes with content after each flavor Chinese medicine extraction, make to contain pure Chinese medicine extraction liquid.Employing to be to control, and control and support bonded method, but not only also external of oral administration of the medicine of making is a kind of reasonable recipe, and compatibility is simplified, the medicine of the treatment coronary heart disease of determined curative effect, treating both the principal and secondary aspects of a disease.
Radix Ginseng's strongly invigorating primordial QI is Gu Tuo Shenglv calms the nerves.The Radix Notoginseng hemostasis, dissipating blood stasis, detumescence, analgesic therapy.The Radix Aconiti Lateralis Preparata recuperating depleted YANG and rescuing the patient from collapse, it is supporing yang to mend fire, dispelling cold and removing dampness.The Radix Curcumae promoting QI circulation for relieving depression, the removing heat from blood removing blood stasis with potent drugs.Hawthorn digesting is long-pending, dissipating blood stasis blood.The Oletum Trogopterori promoting blood circulation, eliminating stasis to stop pain, hemostasis by removing blood stasis.Cortex Cinnamomi complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Lignum Dalbergiae Odoriferae is regulated the flow of vital energy, hemostasis, clots absorbing, analgesic therapy.The Olibanum regulating qi and activating blood, analgesic therapy chases after poison.The Radix Glycyrrhizae Preparata nourishing YIN and benefiting blood, QI invigorating warming YANG, the multiple arteries and veins of only throbbing with fear.
The thoracic obstruction, be because of the stagnation of QI of heart-yang smooth due to, it is pained, is that weakness of QI because of heart-yang exhausts and forms, so the present invention's usefulness Radix Ginseng, Radix Glycyrrhizae QI invigorating heart tonifying; Radix Aconiti Lateralis Preparata, Cortex Cinnamomi warming and activating heart-YANG; Radix Notoginseng, Fructus Crataegi, the pain relieving of Oletum Trogopterori promoting blood circulation to remove blood stasis; Radix Curcumae circulation of qi promoting removing blood stasis with potent drugs; Olibanum, Lignum Dalbergiae Odoriferae sending down the abnormal ascending QI dissipating blood stasis, activating blood circulation and unblocking obstruction.All medicines share, and there have benefit to have to be logical, and emphasis can make the gas of gas sun advance freely at regulating QI to relieve pain, reaches the purpose of " general rule is not bitterly ".Flos Rosae Rugosae regulate the flow of vital energy resolving depression and blood dissipating blood stasis; The CitrusaurantiumL.Var.amara Engl. the chest stuffiness relieving of regulating the flow of vital energy, dispersing the stagnated liver-QI for regulating the stomach, appetizing preventing or arresting vomiting.Two medicines, 5 usefulness, a gas one blood, QI and blood is two transfers, and the strength of eliminating turbid pathogen with aromatics, be amusing appetizing, regulating QI to relieve pain strengthens.Content is the edible ethanol blood circulation promoting and blood stasis dispelling more than 95%, promotes that drug osmotic to cell absorbs.
Medicine of the present invention can also be smeared chest with medicine of the present invention except for oral administration, and the efficacy of a drug sick institute that goes directly so can remove the patient suffering, obtains and imitates in no time.This medicine is applicable to that also whole body smears.Adopt oral administration and externally usedly, drug effect is more remarkable.
It is obvious that the present invention treats the coronary heart disease curative effect, and short treating period can be used for the thoracic obstruction, angina pectoris, angina pectoris.Clinical usefulness repeatly, effect are very prompt.
Medicine of the present invention is through clinical 70 routine patients' clinical verification, and curing number is 42 examples, and significant figure is 21 examples, and invalid number is 7 examples, and total effective rate reaches 90%.Do not see toxic side effect in the therapeutic process, the patient has better curative effect to obstinate.
For further specifying therapeutic effect, it is as follows now to enumerate model case:
Case 1: certain man, 66 years old, suffer from coronary heart disease, show as gas tight, faint, weak, feel sick, vomiting, the violent constriction of the persistence of irregularly showing effect, vexed plug sense, even cutting pains, be positioned at breastbone after, attach most importance to the left side in ordinary wave and whole shirtfront.Through the western medical treatment poor effect.Oral medicine of the present invention, each 10 milliliters, every day 3 times, above disease was alleviated in 10 days, eliminated in 30 days, and it is normal that life recovers.Paying a return visit after 6 months does not have recurrence.
Case 2: certain man, 56 years old, suffer from coronary heart disease, show as epigastrium pain, normal and celiac disease is obscured.With low grade fever, dysphoria, hyperhidrosis and cold sweat are felt sick, vomiting, cardiopalmus, dizziness, extremely weak, dyspnea, dying sense continues often to reach a few hours more than 30 minutes.External medicine of the present invention is smeared chest, and every day 2 times, each 10 milliliters, above disease was alleviated in 5 days, eliminated in 30 days, recovered normal.Paying a return visit after 6 months does not have recurrence.
Case 3: certain woman, 59 years old, suffer from coronary heart disease, original angina pectoris attacks is later on because pathological changes is extensive, cardiac muscle is fibrosis extensively, and angina pectoris reduces to disappearance gradually, the performance of heart failure occurs, and is tight as gas, edema, weak etc., also have various arrhythmia, show as cardiopalmus.Once took the Chinese medicine of a variety of treatment coronary heart disease, but effect is all not good.Oral medicine of the present invention, each 10 milliliters, every day 3 times; This medicine of external is smeared chest, every day 2 times, each 10 milliliters.Above disease was alleviated in 3 days, eliminated in 30 days, recovered normal.Paying a return visit after 8 months does not have recurrence.
The specific embodiment
Embodiment 1
Take by weighing 15 parts of Flos Rosae Rugosaes, 18 parts of CitrusaurantiumL.Var.amara Engl.s, 16 parts of Radix Ginsengs, 16 parts of Radix Notoginseng, 6 parts of Radix Aconiti Lateralis Preparatas, 16 parts of Radix Curcumaes, 16 parts of Fructus Crataegis, 16 parts of Oletum Trogopteroris, 16 parts of Cortex Cinnamomis, 16 parts of Lignum Dalbergiae Odoriferaes, 16 parts of Olibanums, 16 parts of Radix Glycyrrhizae Preparatas adopt the method that decocts the back concentrating under reduced pressure to make Chinese medicine extract respectively, and are standby.
Under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add content and be 18 parts of 96% edible ethanols, be mixed with aqueous solution of alcohol, standby.
Above-mentioned various Chinese medicine extract are added in the aqueous solution of alcohol, fully stirred 120 minutes, precipitate 2 ~ 4 hours, supernatant 200 orders filter, and gained filtrate is the medicine of the treatment coronary heart disease of oral administration or external, carries out fill under aseptic condition.Gained precipitate and filtering residue focus on.
Embodiment 2
The drug component proportioning is: 18 parts of Flos Rosae Rugosaes, and 19 parts of CitrusaurantiumL.Var.amara Engl.s, 17 parts of Radix Ginsengs, 17 parts of Radix Notoginseng, 6 parts of Radix Aconiti Lateralis Preparatas, 17 parts of Radix Curcumaes, 17 parts of Fructus Crataegis, 17 parts of Oletum Trogopteroris, 17 parts of Cortex Cinnamomis, 17 parts of Lignum Dalbergiae Odoriferaes, 17 parts of Olibanums, 17 parts of Radix Glycyrrhizae Preparatas, content are 18 parts of 97% edible ethanols.Other is identical with embodiment 1.
Embodiment 3
The drug component proportioning is: 19 parts of Flos Rosae Rugosaes, and 20 parts of CitrusaurantiumL.Var.amara Engl.s, 19 parts of Radix Ginsengs, 19 parts of Radix Notoginseng, 6 parts of Radix Aconiti Lateralis Preparatas, 17 parts of Radix Curcumaes, 19 parts of Fructus Crataegis, 19 parts of Oletum Trogopteroris, 18 parts of Cortex Cinnamomis, 18 parts of Lignum Dalbergiae Odoriferaes, 18 parts of Olibanums, 19 parts of Radix Glycyrrhizae Preparatas, content are 18 parts of 98% edible ethanols.Other is identical with embodiment 1.
Embodiment 4
The drug component proportioning is: 16 parts of Flos Rosae Rugosaes, and 18 parts of CitrusaurantiumL.Var.amara Engl.s, 17 parts of Radix Ginsengs, 15 parts of Radix Notoginseng, 4 parts of Radix Aconiti Lateralis Preparatas, 18 parts of Radix Curcumaes, 18 parts of Fructus Crataegis, 18 parts of Oletum Trogopteroris, 15 parts of Cortex Cinnamomis, 17 parts of Lignum Dalbergiae Odoriferaes, 18 parts of Olibanums, 16 parts of Radix Glycyrrhizae Preparatas, content are 17 parts of 99% edible ethanols.Other is identical with embodiment 1.
Embodiment 5
The drug component proportioning is: 17 parts of Flos Rosae Rugosaes, and 18 parts of CitrusaurantiumL.Var.amara Engl.s, 19 parts of Radix Ginsengs, 17 parts of Radix Notoginseng, 7 parts of Radix Aconiti Lateralis Preparatas, 19 parts of Radix Curcumaes, 17 parts of Fructus Crataegis, 16 parts of Oletum Trogopteroris, 16 parts of Cortex Cinnamomis, 18 parts of Lignum Dalbergiae Odoriferaes, 19 parts of Olibanums, 18 parts of Radix Glycyrrhizae Preparatas, content are 19 parts of 100% edible ethanols.Other is identical with embodiment 1.
Embodiment 6
The drug component proportioning is: 18 parts of Flos Rosae Rugosaes, and 20 parts of CitrusaurantiumL.Var.amara Engl.s, 19 parts of Radix Ginsengs, 18 parts of Radix Notoginseng, 8 parts of Radix Aconiti Lateralis Preparatas, 16 parts of Radix Curcumaes, 19 parts of Fructus Crataegis, 19 parts of Oletum Trogopteroris, 19 parts of Cortex Cinnamomis, 18 parts of Lignum Dalbergiae Odoriferaes, 19 parts of Olibanums, 20 parts of Radix Glycyrrhizae Preparatas, content are 20 parts of 97% edible ethanols.Other is identical with embodiment 1.
Claims (5)
1. a medicine for the treatment of coronary heart disease is characterized in that it is to be made by the raw material of following weight portion: 1 ~ 20 part of Flos Rosae Rugosae, 1 ~ 20 part of CitrusaurantiumL.Var.amara Engl., 1 ~ 20 part of Radix Ginseng, 1 ~ 20 part of Radix Notoginseng, 1 ~ 20 part of Radix Aconiti Lateralis Preparata, 1 ~ 20 part of Radix Curcumae, 1 ~ 20 part of Fructus Crataegi, 1 ~ 20 part of Oletum Trogopterori, 1 ~ 20 part of Cortex Cinnamomi, 1 ~ 20 part of Lignum Dalbergiae Odoriferae, 1 ~ 20 part of Olibanum, 1 ~ 20 part of Radix Glycyrrhizae Preparata, content are 1 ~ 20 part of edible ethanol more than 95%.
2. medicine as claimed in claim 1 is characterized in that it is to be made by the raw material of following weight portion: 15 ~ 20 parts of Flos Rosae Rugosaes, 15 ~ 20 parts of CitrusaurantiumL.Var.amara Engl.s, 15 ~ 20 parts of Radix Ginsengs, 15 ~ 20 parts of Radix Notoginseng, 4 ~ 8 parts of Radix Aconiti Lateralis Preparatas, 15 ~ 20 parts of Radix Curcumaes, 15 ~ 20 parts of Fructus Crataegis, 15 ~ 20 parts of Oletum Trogopteroris, 15 ~ 20 parts of Cortex Cinnamomis, 15 ~ 20 parts of Lignum Dalbergiae Odoriferaes, 15 ~ 20 parts of Olibanums, 15 ~ 20 parts of Radix Glycyrrhizae Preparatas, content are 15 ~ 20 parts of edible ethanols more than 95%.
3. medicine as claimed in claim 1 or 2 is characterized in that, further contains weight portion and be 1 ~ 5 part azone on the basis of claim 1 or 2 described medicines.
4. the preparation method of claim 1 or 2 described medicines is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Radix Ginseng, Radix Notoginseng, Radix Aconiti Lateralis Preparata, Radix Curcumae, Fructus Crataegi, Oletum Trogopterori, Cortex Cinnamomi, Lignum Dalbergiae Odoriferae, Olibanum and the Radix Glycyrrhizae Preparata of described weight proportion, according to the conventional extracting method of Chinese medicine, the extract of the raw material that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds described weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrate sterilization, fill according to quantity must be treated the medicine of coronary heart disease.
5. the preparation method of the described medicine of claim 3 is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Radix Ginseng, Radix Notoginseng, Radix Aconiti Lateralis Preparata, Radix Curcumae, Fructus Crataegi, Oletum Trogopterori, Cortex Cinnamomi, Lignum Dalbergiae Odoriferae, Olibanum and the Radix Glycyrrhizae Preparata of described weight proportion, according to the conventional extracting method of Chinese medicine, the extract of the raw material that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds described weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) azone step a is extract obtained and described weight proportion adds aqueous solution of alcohol together, stirs 120 minutes, precipitates 2 ~ 4 hours, filter, and gained filtrate sterilization, fill according to quantity must be treated the medicine of coronary heart disease.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102637139A CN101972446B (en) | 2010-08-26 | 2010-08-26 | Medicament for treating coronary disease and preparation method thereof |
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| CN2010102637139A CN101972446B (en) | 2010-08-26 | 2010-08-26 | Medicament for treating coronary disease and preparation method thereof |
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| CN102302739B (en) * | 2011-09-11 | 2013-03-27 | 成殿贵 | Preparation method for traditional Chinese drug for treating yin-cold stagnation type chest stuffiness |
| CN105012891A (en) * | 2015-08-15 | 2015-11-04 | 哈尔滨泉兴科技有限公司 | Medicine composition for efficiently treating heart disease |
| CN104998222A (en) * | 2015-09-03 | 2015-10-28 | 哈尔滨泉兴科技有限公司 | Traditional Chinese medicine for treating cardiopathy |
| CN105193995A (en) * | 2015-11-02 | 2015-12-30 | 张希富 | Quick-acting traditional Chinese medicine granules for treating heart diseases |
| CN105435112A (en) * | 2015-12-27 | 2016-03-30 | 哈尔滨泉兴科技有限公司 | Traditional Chinese medicine for quickly treating heart diseases |
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| CN2169437Y (en) * | 1993-06-17 | 1994-06-22 | 张承德 | Heart-protecting fragrant pendant |
| CN1124153C (en) * | 2001-08-31 | 2003-10-15 | 石家庄以岭药业股份有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN1857708A (en) * | 2006-03-21 | 2006-11-08 | 王文台 | Chinese medicine preparation for treating cavitative gastric ulcer |
| CN101745078B (en) * | 2009-11-18 | 2011-04-06 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating cardiac failure and preparation method thereof |
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