CN101518579B - Pressure stabilizing deoppilant and preparation process - Google Patents
Pressure stabilizing deoppilant and preparation process Download PDFInfo
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- CN101518579B CN101518579B CN2009100383328A CN200910038332A CN101518579B CN 101518579 B CN101518579 B CN 101518579B CN 2009100383328 A CN2009100383328 A CN 2009100383328A CN 200910038332 A CN200910038332 A CN 200910038332A CN 101518579 B CN101518579 B CN 101518579B
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Abstract
The invention relates to the field of medicaments, and discloses a pressure stabilizing deoppilant and a preparation process thereof. The pressure stabilizing deoppilant comprises the following compositions: Eucommia Bark, Kudzuvine Root, Danshen Root, Gambir Plant, rhizoma cibotii, Chinese Angelica, Szechuan Lovage Rhizome, Spina Date Seed, Indian Buead, Thinleaf Milkwort Root-bark, camphor and yeast liquor. The pressure stabilizing deoppilant has the efficacies of tonifying liver and kidney, and calming the liver and suppressing yang hyperactivity, and has functions of preventing and treating headache, dizziness and other discomforts caused by elevation of blood pressure.
Description
Technical field
The present invention relates to field of medicaments, specifically a kind of medicine that is used to prevent, treat hypertension neck pain, the liver and the kidney tonifying.
Background technology
Hypertension is a kind of disease that the modern often suffers from, and patients with hypertension causes the whole body arteriolosclerosis because the arterial pressure persistence raises, thereby influences the blood supply of histoorgan, causes various serious consequences, becomes the complication of hypertension.The hypertension common complication has coronary heart disease, diabetes, heart failure, hyperlipidemia, nephropathy, peripheral arterial disease, apoplexy, left ventricular hypertrophy etc., and is in hypertensive various complication, the most remarkable with the infringement of the heart, brain, kidney.
The hypertensive medicine of a lot of treatments is arranged in the market, have Chinese medicine that Western medicine is also arranged.
Wherein the essence of western medicine of depressurization is to make the matter worse, blood pressure lowering stimulates impaired organ to go to work braving one's illness by blood vessel dilating, diuresis, pressure to realize blood pressure lowering, poor effect, and continuation increasing medication dose can make angiorrhexis, angiemphraxis, the thorough loss of function of organ.And western medicine of depressurization can quicken the development of complication, western medicine of depressurization has serious toxic and side effects, the medical expert is called " catalyst of hypertension complication ", western medicine of depressurization is to the heart, brain, liver, kidney, equal toxic side effect, so some patients complication such as heart disease, cerebrovascular, renal failure can occur.
Chinese medicine is comparatively safe depressor, but the treatment by Chinese herbs effect of prior art is not that clearly curative effect is slow, and cure rate is low.
Summary of the invention
Be the problem of solution prior art existence, but the invention provides the pressure stabilizing deoppilant of the good the liver and the kidney tonifying of a kind of therapeutic effect, prevention, treatment hypertension neck pain.
Another object of the present invention is for providing a kind of preparation method of pressure stabilizing deoppilant.
The present invention is achieved in that
A kind of pressure stabilizing deoppilant comprises following ingredients: the Cortex Eucommiae, Radix Puerariae, Radix Salviae Miltiorrhizae, Ramulus Uncariae Cum Uncis, Rhizoma Cibotii, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Ziziphi Spinosae, Poria, Radix Polygalae, Camphora, fermented wine.
As a preferred embodiment of the present invention, described pressure stabilizing deoppilant comprises following components in part by weight:
Cortex Eucommiae 60-120 part Radix Puerariae 60-120 part Radix Salviae Miltiorrhizae 35-75 part Ramulus Uncariae Cum Uncis 30-60 part Rhizoma Cibotii 20-35 part Radix Angelicae Sinensis 10-30 part Rhizoma Chuanxiong 110-200 part Semen Ziziphi Spinosae 5-25 part Poria 5-20 part Radix Polygalae 5-20 part Camphora 5-20 part 60% fermented wine 500-700 part;
Adjuvant sodium benzoate 1-3 part.
Preferably, described pressure stabilizing deoppilant comprises following components in part by weight:
600 parts of 10 part of 60% fermented wine of 10 parts of Camphoras of 10 parts of Radix Polygalaes of 15 parts of Poria of 150 parts of Semen Ziziphi Spinosaes of 20 parts of Rhizoma Chuanxiongs of 30 parts of Radix Angelicae Sinensis of 40 parts of Rhizoma Cibotii of 50 parts of Ramulus Uncariae Cum Uncis of 80 parts of Radix Salviae Miltiorrhizaes of 80 parts of Radix Puerariaes of the Cortex Eucommiae;
2 parts of adjuvant sodium benzoate.
Optionally, described pressure stabilizing deoppilant comprises following components in part by weight:
500 parts of 5 part of 60% fermented wine of 5 parts of Camphoras of 20 parts of Radix Polygalaes of 25 parts of Poria of 200 parts of Semen Ziziphi Spinosaes of 10 parts of Rhizoma Chuanxiongs of 20 parts of Radix Angelicae Sinensis of 60 parts of Rhizoma Cibotii of 75 parts of Ramulus Uncariae Cum Uncis of 60 parts of Radix Salviae Miltiorrhizaes of 60 parts of Radix Puerariaes of the Cortex Eucommiae;
1 part of adjuvant sodium benzoate.
Optionally, described pressure stabilizing deoppilant comprises following components in part by weight:
700 parts of 20 part of 60% fermented wine of 20 parts of Camphoras of 50 parts of Radix Polygalaes of 5 parts of Poria of 110 parts of Semen Ziziphi Spinosaes of 30 parts of Rhizoma Chuanxiongs of 35 parts of Radix Angelicae Sinensis of 30 parts of Rhizoma Cibotii of 35 parts of Ramulus Uncariae Cum Uncis of 120 parts of Radix Salviae Miltiorrhizaes of 120 parts of Radix Puerariaes of the Cortex Eucommiae;
3 parts of adjuvant sodium benzoate.
The method for preparing pressure stabilizing deoppilant provided by the invention is:
Medical material is made only back standby;
Camphora is added fermented wine dissolve in right amount, filter filtrate for later use;
Sodium benzoate adds water and dissolves in right amount, filters filtrate for later use;
The Cortex Eucommiae, Radix Puerariae, Ramulus Uncariae Cum Uncis, Rhizoma Cibotii, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Poria, Semen Ziziphi Spinosae, Radix Polygalae drying, pulverizing are crossed 24 mesh sieves and are made into coarse powder, add 60% fermented wine dipping 15 days～3 months, with 1～3ml/min speed percolation, obtain concentrated solution;
Camphora and sodium benzoate filtrate are joined respectively in the above-mentioned concentrated solution, stirring and evenly mixing, in the ratio of concentrated solution and water be 1: 1～3: 2 the ratio thin up promptly.
Traditional Chinese medical science medical science thinks that hypertension mainly is liver, the heart, the imbalance of kidney yin sun, and wind, fire, expectorant interact so that excessive rising of liver-YANG, deficiency of qi and blood, medulla renis deficiency, stagnation of phlegm-damp in middle-JIAO.When with the liver and the kidney tonifying, suppressing the hyperactive liver to relieve the wind syndrome, vital energy regualting and blood circulation-promoting, heat clearing away is eliminated the phlegm and is the rule of treatment.Select the Cortex Eucommiae, Radix Puerariae invigorating the liver and kidney in the ancient prescription for use, blood pressure lowering is a monarch drug, is aided with Ramulus Uncariae Cum Uncis heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion; The Rhizoma Cibotii invigorating the liver and kidney removes rheumatism, and strong waist foot, is controlled lumbago, rheumatism at sharp joint; Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong promoting blood circulation to remove obstruction in the collateral, to strengthen the monarch drug the liver and the kidney tonifying, suppressing the hyperactive liver to relieve the wind syndrome, promoting blood circulation to remove obstruction in the collateral are that power is ministerial drug altogether.Semen Ziziphi Spinosae, Poria, Radix Polygalae mind tranquilizing and the heart calming are adjuvant drug.Camphora fragrance is walked to scurry, the through behavior messenger drug of going up of all medicines in the current Zhu Jinger side of drawing.More than all medicines tie in, play the liver and the kidney tonifying altogether, suppressing the hyperactive liver and subsiding YANG, fixed dizzy effect of calming the nerves.
Wherein:
The Cortex Eucommiae, nature and flavor with return through: sweet, warm.Return liver, kidney channel.Function with cure mainly: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Be used for lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Hypertension.
Radix Puerariae, nature and flavor with return through: sweet, hot, cool.Return spleen, stomach warp.Function with cure mainly: expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid rash, yang invigorating antidiarrheal.Be used for fever caused by exogenous pathogens pain, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea is had loose bowels; The hypertension neck pain.
Ramulus Uncariae Cum Uncis, nature and flavor are cool in nature, sweet in the mouth.Function cures mainly: heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion, dizzy, the dysphoric cold of being used to have a headache, diarrhea induced by fright tic, pregnant sub-dysentery, vascular hypertension.
Rhizoma Cibotii, meridian distribution of property and flavor, bitter, sweet, temperature.Return liver, kidney channel.Effect: wind-damp dispelling, invigorating the liver and kidney, strong waist knee joint cures mainly: rheumatic arthralgia, soreness of the waist and knees, weakness of the lower extremities, frequent micturition, the enuresis, leukorrhagia.
Radix Salviae Miltiorrhizae, meridian distribution of property and flavor, hardship is slightly cold.GUIXIN, Liver Channel, effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.Cure mainly: menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Radix Angelicae Sinensis, sweet, hot, temperature.Return liver, the heart, spleen channel.Function with cure mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.The Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.Be used for the amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Rhizoma Chuanxiong, nature and flavor with return through suffering, temperature.Return liver, gallbladder, pericardium channel.Function with cure mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.Be used for menoxenia, amenorrhea dysmenorrhea, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Poria, meridian distribution of property and flavor: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Be used for the edema oliguria, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, palpitation with fear insomnia.
Semen Ziziphi Spinosae, nature and flavor: sweet, flat.Gui Jing: go into the heart, spleen, liver, gallbladder meridian.Function cures mainly: nourishing the liver, mind calming is calmed the nerves, arresting sweating.Control restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.
Radix Polygalae, meridian distribution of property and flavor: bitter, hot, tepor.GUIXIN, kidney, lung meridian.Function cures mainly: the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm detumescence.Be used for the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.
Traditional Chinese medicine grinding and processing, even nanotechnology is also just pulverized Chinese medicine, its concentration does not change, such as 5 kilograms former medicated powder in addition behind nano-pulverization its powder weight still be 5 kilograms, impurity and be unfavorable for that the Plant fiber of absorption of human body still exists wherein, concentration does not change, and drug effect is very low; And boil or high temperature distillation is extracted Chinese medicine and can be caused nutrition to be run off by considerable damage, make the drug effect loss more than 80%, allowing the prescription performance down to best therapeutic effect.And the present invention adopts the production technology of microbial decomposition Chinese medicine fermentation, has protected active ingredient of Chinese herbs to avoid destroying, and improves the Chinese medicine purity and the property of medicine; eliminate the toxic and side effects of medicine, be configured to water preparation, outer spraying is smeared or is pasted; changed traditional method for oral administration; according to the theory of Chinese medicine Transdermal absorption, make the drug molecule aiming target to, at the acupuncture point; targeted delivery of drugs; produce tcm herbal ion stream rapidly, see through skin focus, safe and reliable.
Pressure stabilizing deoppilant provided by the invention has the liver and the kidney tonifying, the effect of suppressing the hyperactive liver and subsiding YANG, and the headache that hypertension is caused, discomfort such as dizzy have prevention and therapeutical effect.Have the following advantages:
1, onset is rapid, theory according to the Chinese medicine Transdermal absorption, make drug molecule aiming target blood, decide the blood administration at the acupuncture point, produce tcm herbal ion stream rapidly, see through the through focus of skin, eliminate dizzy, dizzy, have a headache, have palpitation, breathe hard, symptom such as uncomfortable in chest, use medicine after half an hour blood pressure can reduce 5-10mmHg;
2, effect is lasting, and treatment can be consolidated for a long time, changes pathogeny, can thoroughly control hypertension, and clinical total cure rate is up to 93.8%, to idiopathic hypertension therapeutic better effects if;
3, safe without toxic side effect, external therapy of Chinese herb has no side effect and stimulation, has successfully broken through and has taken medicine for a long time to the murder by poisoning of liver, kidney, digestive tract etc.;
4, easy to use, cost is low.
The pressure stabilizing deoppilant that is used for the treatment of that example of the present invention provides uses through 560 clinical patients, and wherein 45 examples are the severe patient, and 320 examples are the moderate patient, and 195 examples are patients with mild; Patients with mild (often dizzy, feeling of fullness in the head, absent minded, forgetful, tired easily) cure rate is 98%, and effective percentage is 99%; Moderate patient (numbness of lower limbs, hypertension, headache, dizzy) cure rate is 93%, effective percentage is 95%; Cure rate is 90% to severe patient's (hypertension, headache dizzy, with complication such as hypertension, heart diseases), and effective percentage is 93%.
The specific embodiment
To describe the present invention in detail with specific embodiment below, be used for explaining the present invention in this illustrative examples of the present invention and explanation, but not as a limitation of the invention.
Embodiment 1:
The pressure stabilizing deoppilant that present embodiment provides comprises following components in part by weight:
600 parts of 10 part of 60% fermented wine of 10 parts of Camphoras of 10 parts of Radix Polygalaes of 15 parts of Poria of 150 parts of Semen Ziziphi Spinosaes of 20 parts of Rhizoma Chuanxiongs of 30 parts of Radix Angelicae Sinensis of 40 parts of Rhizoma Cibotii of 50 parts of Ramulus Uncariae Cum Uncis of 80 parts of Radix Salviae Miltiorrhizaes of 80 parts of Radix Puerariaes of the Cortex Eucommiae;
2 parts of adjuvant sodium benzoate.
The described method for preparing pressure stabilizing deoppilant is:
Medical material is made only back standby;
Camphora is added fermented wine dissolve in right amount, filter filtrate for later use;
Sodium benzoate adds water and dissolves in right amount, filters filtrate for later use;
The Cortex Eucommiae, Radix Puerariae, Ramulus Uncariae Cum Uncis, Rhizoma Cibotii, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Poria, Semen Ziziphi Spinosae, Radix Polygalae drying, pulverizing are crossed 24 mesh sieves and are made into coarse powder, add 60% fermented wine dipping 15 days～3 months, with 1～3ml/min speed percolation, obtain concentrated solution;
Camphora and sodium benzoate filtrate are joined respectively in the above-mentioned concentrated solution, stirring and evenly mixing, in the ratio of concentrated solution and water be 1: 1～1.5: 1 the ratio thin up promptly.
The pressure stabilizing deoppilant that present embodiment provides can directly be smeared also can make the patch use:
Directly smear, pressure stabilizing deoppilant is spread upon the affected part, as cervical vertebra (DAZHUI acupoint), massage is rubbed to wipe and is made medicine fully penetrate in the skin;
Patch: pressure stabilizing deoppilant liquid 2-3 milliliter is splashed on the non-woven fabrics overlay film, be affixed on cervical vertebra (DAZHUI acupoint) after soaking, paste every day one.
Embodiment 2:
The pressure stabilizing deoppilant that present embodiment provides comprises following components in part by weight:
500 parts of 5 part of 60% fermented wine of 5 parts of Camphoras of 20 parts of Radix Polygalaes of 25 parts of Poria of 200 parts of Semen Ziziphi Spinosaes of 10 parts of Rhizoma Chuanxiongs of 20 parts of Radix Angelicae Sinensis of 60 parts of Rhizoma Cibotii of 75 parts of Ramulus Uncariae Cum Uncis of 60 parts of Radix Salviae Miltiorrhizaes of 60 parts of Radix Puerariaes of the Cortex Eucommiae;
1 part of adjuvant sodium benzoate.
Embodiment 3:
The pressure stabilizing deoppilant that present embodiment provides comprises following components in part by weight:
700 parts of 20 part of 60% fermented wine of 20 parts of Camphoras of 50 parts of Radix Polygalaes of 5 parts of Poria of 110 parts of Semen Ziziphi Spinosaes of 30 parts of Rhizoma Chuanxiongs of 35 parts of Radix Angelicae Sinensis of 30 parts of Rhizoma Cibotii of 35 parts of Ramulus Uncariae Cum Uncis of 120 parts of Radix Salviae Miltiorrhizaes of 120 parts of Radix Puerariaes of the Cortex Eucommiae;
3 parts of adjuvant sodium benzoate.
More than the technical scheme that the embodiment of the invention provided is described in detail, used specific case herein the principle and the embodiment of the embodiment of the invention are set forth, the explanation of above embodiment only is applicable to the principle that helps to understand the embodiment of the invention; Simultaneously, for one of ordinary skill in the art, according to the embodiment of the invention, the part that on the specific embodiment and range of application, all can change, in sum, this description should not be construed as limitation of the present invention.
Claims (5)
1. pressure stabilizing deoppilant, it is characterized in that: described pressure stabilizing deoppilant is made by following components in part by weight:
Cortex Eucommiae 60-120 part, Radix Puerariae 60-120 part, Radix Salviae Miltiorrhizae 35-75 part, Ramulus Uncariae Cum Uncis 30-60 part, Rhizoma Cibotii 20-35 part, Radix Angelicae Sinensis 10-30 part, Rhizoma Chuanxiong 110-200 part, Semen Ziziphi Spinosae 5-25 part, Poria 5-20 part, Radix Polygalae 5-20 part, Camphora 5-20 part, 60% fermented wine 500-700 part;
Adjuvant sodium benzoate 1-3 part.
2. pressure stabilizing deoppilant as claimed in claim 1 is characterized in that: described pressure stabilizing deoppilant is made by following components in part by weight:
80 parts of the Cortexs Eucommiae, 80 parts of Radix Puerariaes, 50 parts of Radix Salviae Miltiorrhizaes, 40 parts of Ramulus Uncariae Cum Uncis, 30 parts of Rhizoma Cibotii, 20 parts of Radix Angelicae Sinensis, 150 parts of Rhizoma Chuanxiongs, 15 parts of Semen Ziziphi Spinosaes, 10 parts in Poria, 10 parts of Radix Polygalaes, 10 parts of Camphoras, 600 parts of 60% fermented wine;
2 parts of adjuvant sodium benzoate.
3. pressure stabilizing deoppilant as claimed in claim 1 is characterized in that: described pressure stabilizing deoppilant is made by following components in part by weight:
60 parts of the Cortexs Eucommiae, 60 parts of Radix Puerariaes, 75 parts of Radix Salviae Miltiorrhizaes, 60 parts of Ramulus Uncariae Cum Uncis, 20 parts of Rhizoma Cibotii, 10 parts of Radix Angelicae Sinensis, 200 parts of Rhizoma Chuanxiongs, 25 parts of Semen Ziziphi Spinosaes, 20 parts in Poria, 5 parts of Radix Polygalaes, 5 parts of Camphoras, 500 parts of 60% fermented wine;
1 part of adjuvant sodium benzoate.
4. pressure stabilizing deoppilant, it is characterized in that: described pressure stabilizing deoppilant is made by following components in part by weight:
120 parts of the Cortexs Eucommiae, 120 parts of Radix Puerariaes, 35 parts of Radix Salviae Miltiorrhizaes, 30 parts of Ramulus Uncariae Cum Uncis, 35 parts of Rhizoma Cibotii, 30 parts of Radix Angelicae Sinensis, 110 parts of Rhizoma Chuanxiongs, 5 parts of Semen Ziziphi Spinosaes, 50 parts in Poria, 20 parts of Radix Polygalaes, 20 parts of Camphoras, 700 parts of 60% fermented wine;
3 parts of adjuvant sodium benzoate.
5. method for preparing as the described pressure stabilizing deoppilant of one of claim 1～4 is characterized in that: described method is,
Medical material is made only back standby;
Camphora is added fermented wine dissolve in right amount, filter filtrate for later use;
Sodium benzoate adds water and dissolves in right amount, filters filtrate for later use;
The Cortex Eucommiae, Radix Puerariae, Ramulus Uncariae Cum Uncis, Rhizoma Cibotii, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Poria, Semen Ziziphi Spinosae, Radix Polygalae drying, pulverizing are crossed 24 mesh sieves and are made into coarse powder, add 60% fermented wine dipping 15 days～3 months, with 1～3ml/min speed percolation, obtain concentrated solution;
Camphora and sodium benzoate filtrate are joined respectively in the above-mentioned concentrated solution, stirring and evenly mixing, in the ratio of concentrated solution and water be 1: 1～3: 2 the ratio thin up promptly.
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| CN104189528A (en) * | 2014-09-25 | 2014-12-10 | 王深涧 | Traditional Chinese medicine composition for treating hypertension, and preparation method of traditional Chinese medicine composition |
| CN104491184B (en) * | 2015-01-21 | 2018-10-26 | 通化斯威药业股份有限公司 | A kind of external used medicine and preparation method that can be adjusted blood pressure, reduce blood fat, soften blood vessel |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1511571A (en) * | 2002-12-31 | 2004-07-14 | 中国中医药科技开发交流中心 | Medicinal composition for preventing and curing hypertension and its preparing method |
| CN101116689A (en) * | 2007-08-17 | 2008-02-06 | 乔兴茂 | Oral Chinese traditional medicine composition for treating hypertension |
| CN101129817A (en) * | 2007-09-26 | 2008-02-27 | 王福春 | Chinese medicine formulation for treating hypertension and method of producing the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1511571A (en) * | 2002-12-31 | 2004-07-14 | 中国中医药科技开发交流中心 | Medicinal composition for preventing and curing hypertension and its preparing method |
| CN101116689A (en) * | 2007-08-17 | 2008-02-06 | 乔兴茂 | Oral Chinese traditional medicine composition for treating hypertension |
| CN101129817A (en) * | 2007-09-26 | 2008-02-27 | 王福春 | Chinese medicine formulation for treating hypertension and method of producing the same |
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