CN102370838B - Kidney-invigorating and tendon-reinforcing double-phase capsule - Google Patents
Kidney-invigorating and tendon-reinforcing double-phase capsule Download PDFInfo
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Abstract
The invention relates to a kidney-invigorating and tendon-reinforcing double-phase capsule and a preparation method thereof. The kidney-invigorating and tendon-reinforcing double-phase capsule comprises a hard capsule, and is prepared by filling micro-capsules which is prepared from solid powder prepared from malaytea scurfpea fruit, scorpio, fortune's drynaria rhizome and prepared rehmannia rhizome as well as an alcohol-soluble core material consisting of cortex eucommiae and dragon's blood into the hard capsule. A prescription of the kidney-invigorating and tendon-reinforcing double-phase capsule is formed by screening formulas on the basis of continually summing up clinical experience, has a refined formula and strict blending, has the effects of invigorating the liver and the kidney, strengthening the bones and muscles, promoting blood circulation and removing obstruction in channels, and is suitable for treating orthopaedic diseases such as limb patellofemoral joint pain and pain in neck, waist and legs caused by deficiency of liver and kidney and stasis of tendons and channels. Compared with the conventional kidney-invigorating and tendon-reinforcing preparations such as tablets, capsules, oral liquids and the like, the kidney-invigorating and tendon-reinforcing double-phase capsule has the characteristics of reduction in the using quantity of auxiliary materials, reduction in the production cost, reduction in the using amount, remarkable curative effect and high stability.
Description
Technical field
The present invention relates to Chinese medicine composition of the strong muscle of a kind of the kidney invigorating and preparation method thereof, particularly strong muscle biphasic capsule of a kind of the kidney invigorating and preparation method thereof.
Background technology
At present; orthopaedic disease is a lot; middle-aged and elderly people particularly; increase along with the age; tend to occur the symptoms such as lumbago and skelalgia, hyperosteogeny, osteoporosis, muscles and bones atrophy, arthralgia, trick be ice-cold, or owing to being engaged in for a long time the painstaking and work such as activity of bending over of waist, often can cause fascia thoracolumbalis muscular strain; or fascia is lax, bones and muscles pain, acute or chronic soft tissue injury, muscles and bones and intervertebral disk hernia pain caused etc., when serious, patient is often agonizing.
When treating for this class orthopaedic disease, majority think because calcium deficiency causes, and in treatment, often only by the mode of replenishing the calcium, cause therapeutic effect not obvious.In the traditional Chinese medical science, think, mostly this class orthopaedic disease be due to deficiency of the liver and kindey, stagnant causing of the muscle arteries and veins stasis of blood, as adopt simple replenishing the calcium to treat, and its old complaint is not nursed one's health, cannot effect a radical cure, mostly the traditional Chinese medical science is to set about carrying out with the kidney invigorating, promoting flow of QI and blood, removing obstruction in the collateral to relieve pain etc. in treatment.
For example, Chinese patent ZL20091009 discloses a kind of capsule for kidney and strengthening bones, medicated powder is by Herba Cistanches 0.5-1.2 part in its capsule, Fructus Psoraleae 0.5-1 part, Semen Cuscutae 0.5-1.2 part, Radix Morindae Officinalis 0.5-1.2 part, Fructus Lycii 0.5-1.2 part, Cortex Eucommiae 0.3-0.8 part, Fructus Corni 0.3-0.8 part, Semen Allii Tuberosi 0.5-1.2 part medicated powder or decoction pieces powder by weight ratio mix, also can add on this basis Fructus Ligustri Lucidi 0.5-1.2 part, Herba Epimedii 0.5-1.2 part, Semen Ziziphi Spinosae 0.5-1 part, Fructus Schisandrae Chinensis 0.5-1 part, and Radix Rehmanniae Preparata, Placenta Hominis, support, Radix Polygoni Multiflori Preparata, Radix Ophiopogonis and Rhizoma Alismatis, this invention energy kidney-replenishing kidney tonifying is cloudy, bone and muscle strengthening, ascending up spleen-Qi and Yang, blood-activating and qi-promoting, by wind dehumidifying, the treatment of the diseases such as menstruction regulating and pain relieving, hyperosteogeny of cervical vertebra, sciatica, arthralgia, osteoporosis, muscles and bones atrophy, prolapse of lumbar intervertebral disc, trick are ice-cold, impotence and seminal emission.Chinese patent 03134285.X, discloses a kind of bone strengthening medicine and with this medicine, has prepared the method for capsule, tablet and oral liquid, and this bone strengthening medicine is by Herba Epimedii, Radix Dipsaci, Radix Paeoniae Rubra, Rhizoma Chuanxiong, the Rhizoma Anemarrhenae, Rhizoma Curcumae, Rhizoma Sparganii, Radix Rehmanniae, Concha Ostreae forms, that each taste raw material is extracted after drug extract, the capsule that drug extract is made, tablet or oral liquid; This invention compositions also has invigorating kidney, promoting blood circulation, the effect of bone and muscle strengthening.
Biphasic capsule is a kind of capsule form that received in recent years more concern, generally the two-phase composition of medicine or pharmaceutical composition (as liquid phase and solid phase composition) isolation separately can be filled in a hard capsule, the capsule of this form can reduce being in contact with one another and producing bad interaction between two-phase composition, also there is the application that can reduce adjuvant composition, the feature reducing production costs.Chinese patent ZL200410000857.x discloses a kind of ageratum double phases hard capsule of distinguishing filling liquid composition and solid composition and its preparation method and application.The preparation method of this hard capsule is to choose after raw material by raw material and the usage ratio of pharmacopeia regulation, and the Constituents of The Essential Oil that extracts gained is made to drop pill or soft capsule; The residue and the conventional decocting of other raw materials that extract after Constituents of The Essential Oil are got liquid, precipitate with ethanol or ultrafiltration, after removing the macromole organic impuritiess such as cellulose, natural gum, concentrate drying adopts a step boiling granulating, obtain uniform granule, again granule, drop pill or soft capsule are packed in hard capsule, sealing, packing, finished product.200510018778.6 of Chinese patent ZL200510018780.3 and Chinese patents disclose respectively Chinese medicine compound Radix Notoginseng biphasic capsule of Chinese medicine compound Lignum Dalbergiae Odoriferae biphasic capsule of a kind of oral administration and preparation method thereof and a kind of oral administration and preparation method thereof.Biphasic capsule described in above-mentioned three Chinese patents, its advantage is all to utilize a kind of method of liquid composition and the packing of solid composition, reduce the volatilization of volatile oil, reduce and between these compositions, mix caused chemistry and physical change, and the application that reduces other adjuvants, thereby reduce costs, reduce dose.At present, aspect the strong muscle of the kidney invigorating, not yet there is this dosage form of biphasic capsule.
Summary of the invention
The object of the invention is for above-mentioned deficiency, provide a kind of have invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to remove obstruction in the collateral effect, be used for the treatment of by deficiency of the liver and kindey strong muscle biphasic capsule of the kidney invigorating of the stagnant caused bones of limbs arthralgia of the muscle arteries and veins stasis of blood, neck, waist and leg pain class orthopaedic disease and preparation method thereof.
For addressing the above problem, the technical solution adopted in the present invention is: the strong muscle biphasic capsule of a kind of the kidney invigorating, comprise a hard capsule, the solid powder being made by Fructus Psoraleae, Scorpio, Rhizoma Drynariae and Radix Rehmanniae Preparata is housed in hard capsule, and the in-built alcohol soluble constituent being also equipped with by the Cortex Eucommiae, Sanguis Draxonis of hard capsule is the microcapsule that core makes.
In described hard capsule, the parts by weight of Chinese medicinal components are: Cortex Eucommiae 3-9 part, Sanguis Draxonis 0.5-1.5 part, Fructus Psoraleae 2-5 part, Scorpio 0.5-1.5 part, Rhizoma Drynariae 7-13 part, Radix Rehmanniae Preparata 7-13 part.
The preparation method of the strong muscle biphasic capsule of a kind of the kidney invigorating of the present invention, comprises following steps:
1) get by weight the Cortex Eucommiae, Sanguis Draxonis, the ethanol extraction that is 60%-80% with mass fraction 2-4 time, each 1-2 hour, collects each extracting solution, obtains the alcohol soluble constituent of the Cortex Eucommiae, Sanguis Draxonis;
2) microcapsule preparation: adopt the Microencapsulation method of Chinese traditional medicine of Chinese medicine approval, the alcohol soluble constituent of the gained Cortex Eucommiae, Sanguis Draxonis of take is microcapsule core, chooses and is applicable to microcapsule capsule material, is prepared into microcapsule;
3) Fructus Psoraleae by weight, Scorpio, Rhizoma Drynariae, Radix Rehmanniae Preparata are ground into fine powder, cross 200 mesh sieves, obtain solid powder, standby;
4) by step (2) gained microcapsule and step (3) gained solid powder, be packed in hard capsule, make finished product.
The hard capsule of described hard capsule for being prepared from by the conventional preparation technology of galenic pharmacy approval.
Described microcapsule capsule material is selected from natural polymer medical adjuvant and synthetic medical high-molecular additive.
Described natural polymer medical adjuvant comprises gelatin, arabic gum, sodium alginate, cellulose and cellulosic derivant, chitosan; Synthetic medical high-molecular additive comprises the 1-3 kind in copolymer, polyvinyl alcohol, polyvinylpyrrolidone and the Polyethylene Glycol of polymethylacrylic acid, polymethyl methacrylate, polymethylacrylic acid and poly-methyl polyacrylate.
The present invention is as follows with respect to the beneficial effect of prior art:
(1) the strong muscle biphasic capsule of the kidney invigorating of the present invention, its prescription is on the basis of constantly summing up clinical experience, to screen prescription to form, refining formula, compatibility is rigorous, follow the rule of the whole conditioning of the traditional Chinese medical science, treating both the principal and secondary aspects of a disease, there is invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to remove obstruction in the collateral effect, be applicable to treatment by deficiency of the liver and kindey, the stagnant caused bones of limbs arthralgia of the muscle arteries and veins stasis of blood, neck, waist and leg pain class orthopaedic disease;
(2) the strong muscle biphasic capsule of kidney of the present invention adopts the effective ingredient of Chinese medicinal components in prescription is prepared into respectively to solid powder and alcohol soluble constituent, carries out packing, makes biphasic capsule; And in biphasic capsule, be alcohol soluble constituent to be adopted to the microencapsulation method of Chinese medicine, be prepared into microcapsule, can make liquid Chinese medicine solid state, reduce preparation resistance, improve quality and the stability of medicine; The form of whole biphasic capsule can reduce the consumption of adjuvant, reduces production costs, and reduces consumption, and with respect to preparations such as the existing tablet for the strong muscle of the kidney invigorating, capsule, oral liquids, the strong muscle biphasic capsule of this kidney invigorating drug effect is remarkable, good stability.In addition, also have, have no side effect, take, feature easy to carry.
The specific embodiment
Below by embodiment, the present invention is described in further details, these embodiment are only used for illustrating the present invention, do not limit the scope of the invention.
embodiment 1adopt following traditional Chinese medicine raw and preparation method to prepare the strong muscle biphasic capsule of the kidney invigorating of the present invention.
1, in hard capsule, the parts by weight of Chinese medicinal components are: 3 parts of the Cortexs Eucommiae, 0.5 part of Sanguis Draxonis, 2 parts of Fructus Psoraleaes, 0.5 part of Scorpio, 7 parts of Rhizoma Drynariae, 7 parts, Radix Rehmanniae Preparata.
2, preparation method:
(1) the alcohol soluble constituent of the Cortex Eucommiae, Sanguis Draxonis preparation: get the Cortex Eucommiae, the Sanguis Draxonis of above-mentioned parts by weight, the ethanol extraction that is 60% with mass fraction 2 times, each 1 hour, collect each extracting solution, obtain the alcohol soluble constituent of the Cortex Eucommiae, Sanguis Draxonis;
(2) microcapsule preparation: the alcohol soluble constituent of the gained Cortex Eucommiae, Sanguis Draxonis of take is microcapsule core, take natural polymer medical adjuvant: gelatin, arabic gum, sodium alginate are microcapsule capsule material, adopt the Microencapsulation method of Chinese traditional medicine of Chinese medicine approval, prepare microcapsule;
(3) Fructus Psoraleae of above-mentioned parts by weight, Scorpio, Rhizoma Drynariae, Radix Rehmanniae Preparata are ground into fine powder, cross 200 mesh sieves, obtain solid powder, standby;
(4) by step (2) gained microcapsule and step (3) gained solid powder, be packed in hard capsule, make finished product.
embodiment 2adopt following traditional Chinese medicine raw and preparation method to prepare the strong muscle biphasic capsule of the kidney invigorating of the present invention.
1, in hard capsule, the parts by weight of Chinese medicinal components are: 5 parts of the Cortexs Eucommiae, 0.75 part of Sanguis Draxonis, 2.5 parts of Fructus Psoraleaes, 0.75 part of Scorpio, 8.5 parts of Rhizoma Drynariae, 8.5 parts, Radix Rehmanniae Preparata.
2, preparation method:
(1) the alcohol soluble constituent of the Cortex Eucommiae, Sanguis Draxonis preparation: get the Cortex Eucommiae, the Sanguis Draxonis of above-mentioned parts by weight, the ethanol extraction that is 65% with mass fraction 2 times, each 1.5 hours, collect each extracting solution, obtain the alcohol soluble constituent of the Cortex Eucommiae, Sanguis Draxonis;
(2) microcapsule preparation: the alcohol soluble constituent of the gained Cortex Eucommiae, Sanguis Draxonis of take is microcapsule core, take natural polymer medical adjuvant: chitosan is microcapsule capsule material, adopts the Microencapsulation method of Chinese traditional medicine of Chinese medicine approval, prepares microcapsule;
(3) Fructus Psoraleae of above-mentioned parts by weight, Scorpio, Rhizoma Drynariae, Radix Rehmanniae Preparata are ground into fine powder, cross 200 mesh sieves, obtain solid powder, standby;
(4) by step (2) gained microcapsule and step (3) gained solid powder, be packed in hard capsule, make finished product.
embodiment 3adopt following traditional Chinese medicine raw and preparation method to prepare the strong muscle biphasic capsule of the kidney invigorating of the present invention.
1, in hard capsule, the parts by weight of Chinese medicinal components are: 6 parts of the Cortexs Eucommiae, 1 part of Sanguis Draxonis, 3.5 parts of Fructus Psoraleaes, 1 part of Scorpio, 10 parts of Rhizoma Drynariae, 10 parts, Radix Rehmanniae Preparata.
2, preparation method:
(1) the alcohol soluble constituent of the Cortex Eucommiae, Sanguis Draxonis preparation: get the Cortex Eucommiae, the Sanguis Draxonis of above-mentioned parts by weight, the ethanol extraction that is 70% with mass fraction 3 times, each 1.5 hours, collect each extracting solution, obtain the alcohol soluble constituent of the Cortex Eucommiae, Sanguis Draxonis;
(2) microcapsule preparation: the alcohol soluble constituent of the gained Cortex Eucommiae, Sanguis Draxonis of take is microcapsule core, take natural polymer medical adjuvant: cellulose and cellulose derivative are microcapsule capsule material, adopt the Microencapsulation method of Chinese traditional medicine of Chinese medicine approval, prepare microcapsule;
(3) Fructus Psoraleae of above-mentioned parts by weight, Scorpio, Rhizoma Drynariae, Radix Rehmanniae Preparata are ground into fine powder, cross 200 mesh sieves, obtain solid powder, standby;
(4) by step (2) gained microcapsule and step (3) gained solid powder, be packed in hard capsule, make finished product.
embodiment 4adopt following traditional Chinese medicine raw and preparation method to prepare the strong muscle biphasic capsule of the kidney invigorating of the present invention.
1, in hard capsule, the parts by weight of Chinese medicinal components are: 7 parts of the Cortexs Eucommiae, 1.25 parts of Sanguis Draxonis, 4.5 parts of Fructus Psoraleaes, 1.25 parts of Scorpios, 11.5 parts of Rhizoma Drynariae, 11.5 parts, Radix Rehmanniae Preparata.
2, preparation method:
(1) the alcohol soluble constituent of the Cortex Eucommiae, Sanguis Draxonis preparation: get the Cortex Eucommiae, the Sanguis Draxonis of above-mentioned parts by weight, the ethanol extraction that is 75% with mass fraction 3 times, each 2 hours, collect each extracting solution, obtain the alcohol soluble constituent of the Cortex Eucommiae, Sanguis Draxonis;
(2) microcapsule preparation: the alcohol soluble constituent of the gained Cortex Eucommiae, Sanguis Draxonis of take is microcapsule core, take and synthesizes medical high-molecular additive: polymethylacrylic acid, be microcapsule capsule material, the Microencapsulation method of Chinese traditional medicine that adopts Chinese medicine to approve, prepares microcapsule;
(3) Fructus Psoraleae of above-mentioned parts by weight, Scorpio, Rhizoma Drynariae, Radix Rehmanniae Preparata are ground into fine powder, cross 200 mesh sieves, obtain solid powder, standby;
(4) by step (2) gained microcapsule and step (3) gained solid powder, be packed in hard capsule, make finished product.
embodiment 5adopt following traditional Chinese medicine raw and preparation method to prepare the strong muscle biphasic capsule of the kidney invigorating of the present invention.
1, in hard capsule, the parts by weight of Chinese medicinal components are: 9 parts of the Cortexs Eucommiae, 1.5 parts of Sanguis Draxonis, 5 parts of Fructus Psoraleaes, 1.5 parts of Scorpios, 13 parts of Rhizoma Drynariae, 13 parts, Radix Rehmanniae Preparata.
2, preparation method:
(1) the alcohol soluble constituent of the Cortex Eucommiae, Sanguis Draxonis preparation: get the Cortex Eucommiae, the Sanguis Draxonis of above-mentioned parts by weight, the ethanol extraction that is 80% with mass fraction 4 times, each 2 hours, collect each extracting solution, obtain the alcohol soluble constituent of the Cortex Eucommiae, Sanguis Draxonis;
(2) microcapsule preparation: the alcohol soluble constituent of the gained Cortex Eucommiae, Sanguis Draxonis of take is microcapsule core, take and synthesizes medical high-molecular additive: polyvinylpyrrolidone and Polyethylene Glycol are microcapsule capsule material, adopts the Microencapsulation method of Chinese traditional medicine of Chinese medicine approval, prepares microcapsule;
(3) Fructus Psoraleae of above-mentioned parts by weight, Scorpio, Rhizoma Drynariae, Radix Rehmanniae Preparata are ground into fine powder, cross 200 mesh sieves, obtain solid powder, standby;
(4) by step (2) gained microcapsule and step (3) gained solid powder, be packed in hard capsule, make finished product.
embodiment 6clinical treatment case.
1, case one: grandson so-and-so, man, 58 years old, government organs' work, sciatica 2 years, the conscious soreness of waist, lumbago, debility of the waist, be that deficiency of the liver and kindey causes through clinical diagnosis, through taking the strong muscle biphasic capsule of the kidney invigorating of the present invention, after 4 weeks, the soreness of waist, lumbago, debility of the waist symptom are clearly better, and continue to take 2 courses for the treatment of, sciatica takes a turn for the better, and mental attitude improves.
2, case two: Lee so-and-so, female, 66 years old, retirement, suffered from hyperosteogeny, normal lumbar and back pain, meets cold pain in the lumbar region and often recurs, and once adopt the treatments such as medicine, acupuncture, massage, but effect is not remarkable.Diagnosis finds, its have a haggard face, fear cold, light red tongue is pale, is diagnosed as lumbago due to renal deficiency, the deficiency of liver-QI of holding concurrently.Through the strong muscle biphasic capsule of oral the kidney invigorating of the present invention, after 1 course for the treatment of, symptom obviously alleviates, and continues to take after 4 courses for the treatment of, and lumbar and back pain symptom is cured.
3, case three: king so-and-so, man, 49 years old, peasant, conscious left lower extremity arthralgia, especially meets rainy weather or overworks and easily cause joint aches aggravation, lies awake all night, with fear of cold.Diagnose discovery patient to take pain as main, pain in fixed position, has very night, and comprehensive analysis to both pulse manifestation and symptoms is cold-evil's retardance, is blood operation not smooth, and the muscle arteries and veins stasis of blood is stagnant, mistake is foster.The strong muscle two-phase of this kidney invigorating of oral administration glue is after 2 courses for the treatment of, and pain relief, continues to take 4 courses for the treatment of, and lumbago disappears substantially, unconsciously aches and tire out after work, and evening is painless.
Claims (5)
1. a preparation method for the strong muscle biphasic capsule of the kidney invigorating, is characterized in that: in hard capsule, the parts by weight of Chinese medicinal components are: Cortex Eucommiae 3-9 part, Sanguis Draxonis 0.5-1.5 part, Fructus Psoraleae 2-5 part, Scorpio 0.5-1.5 part, Rhizoma Drynariae 7-13 part, Radix Rehmanniae Preparata 7-13 part; Preparation method comprises following steps:
(1) get by weight the Cortex Eucommiae, Sanguis Draxonis, the ethanol extraction that is 60%-80% with mass fraction 2-4 time, each 1-2 hour, collects each extracting solution, obtains the alcohol soluble constituent of the Cortex Eucommiae, Sanguis Draxonis;
(2) microcapsule preparation: adopt the Microencapsulation method of Chinese traditional medicine of Chinese medicine approval, the alcohol soluble constituent of the gained Cortex Eucommiae, Sanguis Draxonis of take is microcapsule core, chooses and is applicable to microcapsule capsule material, is prepared into microcapsule;
(3) will be by weight, the Fructus Psoraleae taking, Scorpio, Rhizoma Drynariae, Radix Rehmanniae Preparata are ground into fine powder, cross 200 mesh sieves, obtain solid powder, standby;
(4) by step (2) gained microcapsule and step (3) gained solid powder, be packed in hard capsule, make finished product.
2. the preparation method of the strong muscle biphasic capsule of the kidney invigorating according to claim 1, is characterized in that: the hard capsule of described hard capsule for being prepared from by the conventional preparation technology of galenic pharmacy approval.
3. the preparation method of the strong muscle biphasic capsule of the kidney invigorating according to claim 2, is characterized in that: described microcapsule capsule material is selected from natural polymer medical adjuvant and synthetic medical high-molecular additive.
4. the preparation method of the strong muscle biphasic capsule of the kidney invigorating according to claim 3, is characterized in that: described natural polymer medical adjuvant is gelatin, arabic gum, sodium alginate, cellulose and cellulosic derivant, chitosan; Synthetic medical high-molecular additive is the 1-3 kind in copolymer, polyvinyl alcohol, polyvinylpyrrolidone and the Polyethylene Glycol of polymethylacrylic acid, polymethyl methacrylate, polymethylacrylic acid and poly-methyl polyacrylate.
5. the strong muscle biphasic capsule of the kidney invigorating of being prepared by the preparation method of the strong muscle biphasic capsule of a kind of the kidney invigorating claimed in claim 1, comprise a hard capsule, it is characterized in that: the solid powder being made by Fructus Psoraleae, Scorpio, Rhizoma Drynariae and Radix Rehmanniae Preparata is housed in hard capsule, and the alcohol soluble constituent being also equipped with in hard capsule by the Cortex Eucommiae, Sanguis Draxonis is the microcapsule that core makes.
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| Title |
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| 三联疗法治疗肝肾亏虚型腰椎间盘突出症临床疗效观察;刘卫明;《中国优秀硕士学位论文全文数据库医药卫生科技辑》;20101015(第10期);第25-26页 * |
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