CN105250397A - Spirulina traditional Chinese medicine composition - Google Patents
Spirulina traditional Chinese medicine composition Download PDFInfo
- Publication number
- CN105250397A CN105250397A CN201510646993.4A CN201510646993A CN105250397A CN 105250397 A CN105250397 A CN 105250397A CN 201510646993 A CN201510646993 A CN 201510646993A CN 105250397 A CN105250397 A CN 105250397A
- Authority
- CN
- China
- Prior art keywords
- spirulina
- chinese medicine
- herba
- medicine composition
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a spirulina traditional Chinese medicine composition for treating osteoarthritis and a preparation method thereof and belongs to the field of traditional Chinese medicines. The traditional Chinese medicines, namely spirulina, thesium chinense, dodonaea viscosa and a canton salomonia herb, are used as raw materials to be prepared into active ingredients, and the active ingredients and commonly-used pharmaceutical preparation serving as an auxiliary material are prepared into an oral preparation. The spirulina traditional Chinese medicine composition has definite therapeutic effect on the osteoarthritis.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicinal composition preparation for the treatment of osteoarthritis and preparation method thereof, belong to technical field of Chinese medicines.
Technical background
Osteoarthritis is also known as osteoarthritis, proliferative arthritis, senile arthritis, osteoarthritis, hypertrophiarthritis etc., and be a kind of chronic joint diseases, it mainly changes is articular cartilage degenerative disease and Secondary cases hyperosteogeny.Constitutional osteoarthritis and secondary osteoarthrosis is divided into according to pathogenic factors, more common with secondary osteoarthrosis in China, namely because certain known reason causes cartilage destruction or articulation structure to change, cause degeneration person to be called secondary osteoarthrosis because of factors such as articular surface friction or pressure imbalances in the future, clinically produce the symptoms such as arthralgia, limitation of activity and joint deformity, this illness is with the far-end of hands and proximal interphalangeal joint, knee joint, elbow, shoulder and joint of vertebral column are easily got involved, and wrist, ankle joint be less morbidity then.
The treatment of osteoarthritis is mainly Chinese and western drugs treatment and non-drug therapy, and wherein non-drug therapy is that Patients ' Healthy Education, autotraining, range of motion training, exercise for power, the use of walk help instrument, baker-kneed wedge shoe pad, occupational therapy and joint are protected, the auxiliary equipment etc. of daily life; Western medicine comprises: hyaluronate sodium intraarticular injection, oral glucosamine, oral or external non-steroidal antalgic anti-inflammatory agent.
Osteoarthritis belongs to Chinese medicine " rheumatism involving the bone ", " knee joint numbness " category, and Chinese medicine thinks that wind, cold, wet, pathogenic heat are the external condition that development occurs arthritis, and all empty internal memories, positive QI-insufficiency is its morbidity immanent cause; Under this etiology and pathogenesis instructs, no matter for oral administration and external application Chinese medicine greatly mainly with correction eliminating evil be rule for the treatment of prescription medicine.
Chinese medicine composition that China Patent Publication No. CN103006946 discloses " treatment osteoarthritis and rheumatoid arthritis " and preparation method thereof, this invention is made up of herb lorathlorace, Radix Angelicae Pubescentis, Hippocampus, Fructus Lycii, Radix Ginseng, the Radix Paeoniae Alba, Radix Gentianae Macrophyllae, the Cortex Eucommiae, Radix Dipsaci, Rhizoma Cibotii, Radix Achyranthis Bidentatae, Fructus Chaenomelis, Rhizoma Homalomenae, Poria, Radix Angelicae Sinensis, Cortex Magnoliae Officinalis, Cortex Cinnamomi, Fructus Foeniculi, Rhizoma Chuanxiong, Herba Schizonepetae and Radix Glycyrrhizae, and said composition is to nourish warming YANG class Chinese medicine.China Patent Publication No. CN103006884A discloses " a kind of Chinese medicine composition for the treatment of osteoarthritis and preparation method thereof ", this invention is made up of Radix Angelicae Pubescentis, the Cortex Eucommiae, Herba Taxilli, Radix Cyathulae, Herba Asari, Radix Gentianae Macrophyllae, Radix Rehmanniae Preparata, Poria, Cortex Cinnamomi, Radix Saposhnikoviae, Rhizoma Chuanxiong, Radix Codonopsis, Radix Glycyrrhizae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Myrrha, Rhizoma Atractylodis and Cortex Phellodendri, said composition is with damp-clearing pain-relieving, and liver and kidney tonifying Chinese medicine is main.Chinese invention patent publication number CN102302616A open " treatment knee osteoarthritis cataplasma and preparation method thereof ", its medicinal ingredient is made up of Radix Notoginseng, Radix Lamiophlomidis Rotatae, Daphne giraldii Nitsche, Borneolum Syntheticum.Above-mentioned taking orally is mainly the kidney invigorating damp eliminating, promoting blood circulation and stopping pain side's medicine with external medicine composition.
The present invention is the Chinese medicine composition that science screening and dosage ratio obtain from Chinese crude drug, and each medical material synergism, plays clearing heat for detumescence, dredges muscle analgesic effect, thus improves patient articular's swelling pain symptom; Compared with Western medicine, have toxic and side effects little, be suitable for the advantage of long-term taking, the crowd being suitable for suffering from osteoarthritis takes.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition, under guidance of traditional Chinese medicine theory, by the rational proportion of each medical material, synergism, plays the effect for the treatment of osteoarthritis.Another one object of the present invention is to provide the preparation method of this Chinese medicine composition.
The Chinese medicine composition for the treatment of osteoarthritis of the present invention, spirulina, Herba Thesii, car Mulberry son, Herba Salomoniae Cantoniensis is selected to be raw material, wherein spirulina is the frond of the multiple spirulinas such as Oscillariaceae plant spirulina plalensis, Special Traditional Chinese Medicine in Yunnan material, be included in " Yunnan Province's Chinese crude drug standard (version in 2005) (first) " at present, there is QI invigorating, improve immunity of organisms effect, present ingredient analysis shows, spirulina is rich in a large amount of protein, the nutritional labeling such as multivitamin and fatty acid; Herba Thesii is the herb of Santalaceae plant Herba Thesii, has antipyretic and antidote functions; Car Mulberry son is the herb of young Dodonaeaviscosa (L.) Jacq. of Meliaceae car Mulberry, and mildly bitter flavor, the pungent temperature of property, have heat-clearing toxin-expelling functions; Herba Salomoniae Cantoniensis is the herb of milk wort tooth fruit grass, and micro-pungent, the property of taste is put down, and has heat-clearing toxin-expelling functions.Above-mentioned Chinese crude drug reasonable compatibility, the effect of common embodiment clearing heat for detumescence.
The raw material dosage preparing medicine activity component of the present invention is: spirulina 5-25 part, Herba Thesii 10-20 part, the young 5-15 part of car Mulberry, Herba Salomoniae Cantoniensis 5-15 part; Be preferably spirulina 12 parts, Herba Thesii 12 parts, car Mulberry young 9 parts, Herba Salomoniae Cantoniensis 9 parts.
Chinese medicine composition of the present invention can adopt Chinese medicine preparation conventional method to be prepared into traditional oral preparation.
Spirulina 12 parts, Herba Thesii 12 parts, car Mulberry young 9 parts and Herba Salomoniae Cantoniensis 9 parts, young and the Herba Salomoniae Cantoniensis mixing by the Herba Thesii of above-mentioned weight proportion, car Mulberry, add 3 times amount water soaking 2 hours, heating decoction 2 hours, filters, and medicinal residues add 1 times of water gaging heating decoction 1 hour again, filter, merge twice filtrate, leave standstill 1 hour, pour out supernatant; Relative density 1.05 extractum during supernatant concentration to 60 DEG C, vacuum drying, pulverizes dry solid content, obtains fine powder after sieving; This prepares fine powder and Spirulina powder mixes, and sieves, and obtains fine powder.This fine powder can add the adjuvant preparing different solid dosage forms needs, as lubricant, binding agent etc., is prepared into Conventional solid preparation as tablet, capsule, granule etc.
Below in conjunction with embodiment, the invention will be further elaborated
Embodiment 1 capsule preparation of the present invention
1. take each crude drug by following weight proportion: spirulina 50 grams, Herba Thesii 100 grams, car Mulberry son 50 grams and Herba Salomoniae Cantoniensis 50 grams are for subsequent use;
2. above-mentioned weight Herba Thesii, car Mulberry son and Herba Salomoniae Cantoniensis add 3 times amount water soaking 2 hours, and heating decoction 2 hours, filters, and medicinal residues add 1 times of water gaging heating decoction 1 hour again, filter, merge twice filtrate, standing 1 hour, pour out supernatant; Relative density 1.05 extractum during supernatant concentration to 60 DEG C, vacuum drying, pulverizes dry solid content, obtains fine powder 13 grams after sieving;
3, above-mentioned 2 prepare fine powder and Spirulina powder 50 grams mixes, and sieve, obtain fine powder; Mix after adding adjuvant, load snap fit capsule.
Embodiment 2 tablet preparation of the present invention
1. take each crude drug by following weight proportion: spirulina 250 grams, Herba Thesii 200 grams, car Mulberry son 150 grams and Herba Salomoniae Cantoniensis 150 grams are for subsequent use;
2. above-mentioned weight Herba Thesii, car Mulberry son and Herba Salomoniae Cantoniensis add 5 times amount water soaking 2 hours, and heating decoction 2 hours, filters, and medicinal residues add 3 times of water gagings heating decoctions 1 hour again, filter, merge twice filtrate, standing 1 hour, pour out supernatant; Relative density 1.10 extractum during supernatant concentration to 60 DEG C, vacuum drying, pulverizes dry solid content, obtains fine powder 30 grams after sieving;
3. above-mentioned 2 prepare fine powder and Spirulina powder 250 grams mixes, and sieve, obtain fine powder; Granule is made after adding adjuvant, dry, tabletting.
Embodiment 3 granule preparation of the present invention
1. take each crude drug by following weight proportion: spirulina 120 grams, Herba Thesii 120 grams, car Mulberry son 90 grams and Herba Salomoniae Cantoniensis 90 grams are for subsequent use;
2. above-mentioned weight Herba Thesii, car Mulberry son and Herba Salomoniae Cantoniensis add 5 times amount water soaking 2 hours, and heating decoction 2 hours, filters, and medicinal residues add 3 times of water gagings heating decoctions 1 hour again, filter, merge twice filtrate, standing 1 hour, pour out supernatant; Relative density 1.10 extractum during supernatant concentration to 60 DEG C, vacuum drying, pulverizes dry solid content, obtains fine powder 18 grams after sieving;
3. above-mentioned 2 prepare fine powder and Spirulina powder 120 grams mixes, and sieve, obtain fine powder, add adjuvant and make granule.
Experimental example 1 Chinese medicine composition of the present invention is to the inhibitory action of rat assist agent arthritis
1. laboratory animal
SPF level SD experimental rat 60, male and female half and half, body weight 200 ± 10g, conventional point cage is fed.
2. animal grouping
Above-mentioned laboratory animal random packet is 5 groups, comprise blank group, cortisone group (positive controls), tested group of the present composition (high, medium and low dosage), often organize 12.
3. experimental technique
With Freund Freund's complete adjuvant, inflammation is caused to rat foot, administration from causing scorching first 2 days, medication is: Chinese medicine composition tested material stock solution of the present invention is diluted to respective concentration (20.0g/kg, 10.0g/kg and 5.0g/kg) gastric infusion respectively, blank group gavage normal saline, positive controls hydrocortisone acetate 25mg/kg subcutaneous injection, 1 time every other day; Cause scorching rear administration in 21st day and respectively organize drug withdrawal.Adopt volumetric method measurement rat to cause the volume of the rear different time points of scorching foot, by following formulae discovery swelling, the results are shown in Table 1.
4. experimental result
The different time points of each group of tested treated animal 3h, 2d, 12d, 21d after causing inflammation, rat paw edema degree is organized with blank more all has significant difference (P < 0.05); Causing in the scorching rear each time point of 3h, 2d, 12d, 21d, each group of 2d paw swelling peaks, on a declining curve gradually after 12d and 21d, relevant with each group of drug effect on the one hand, also illustrates that this experimental animal model is successfully prepared on the other hand.In each time point of 3h, 2d, 12d, 21d, each tested material various dose group presents the dose-effect positive correlation trend determined.Point out thus: Chinese medicine composition of the present invention has the effect improving rat assist agent arthritis pathological changes.
Table 1 Chinese medicine composition of the present invention is on the impact (N=12, X ± SD) of rat assist agent arthritis
* representative compares P < 0.05 with blank group.
Claims (4)
1. treat a Chinese medicine composition for osteoarthritis, it is characterized in that its active component is made up of the crude drug of following weight portion: spirulina 5-25 part, Herba Thesii 10-20 part, the young 5-15 part of car Mulberry, Herba Salomoniae Cantoniensis 5-15 part.
2. Chinese medicine composition according to claim 1, wherein the consumption of each crude drug is: spirulina 12 parts, Herba Thesii 12 parts, car Mulberry young 9 parts, Herba Salomoniae Cantoniensis 9 parts.
3. the preparation method of Chinese medicine composition according to claim 1 or 2, comprises the steps:
1) take each crude drug spirulina, Herba Thesii, car Mulberry is young, Herba Salomoniae Cantoniensis is for subsequent use;
2), Herba Salomoniae Cantoniensis mixing young by the Herba Thesii of above-mentioned weight proportion, car Mulberry, adds 3-5 times amount water soaking 2 hours, heating decoction 2 hours, filter, medicinal residues add 1-3 times of water gaging heating decoction 1 hour again, filter, merge twice filtrate, leave standstill 1 hour, pour out supernatant; Relative density 1.05-1.10 extractum during supernatant concentration to 60 DEG C, vacuum drying; Pulverize dry solid content, after sieving, obtain fine powder;
3) fine powder and 1 above-mentioned 2) prepared) Spirulina powder for subsequent use mixes, sieves, be i.e. the active component of this Chinese medicine composition.
4. preparation method according to claim 3, by step 3) active component commonly use adjuvant with pharmaceutical preparation and mix, be prepared into solid preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510646993.4A CN105250397A (en) | 2015-09-22 | 2015-09-22 | Spirulina traditional Chinese medicine composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510646993.4A CN105250397A (en) | 2015-09-22 | 2015-09-22 | Spirulina traditional Chinese medicine composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105250397A true CN105250397A (en) | 2016-01-20 |
Family
ID=55090532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510646993.4A Pending CN105250397A (en) | 2015-09-22 | 2015-09-22 | Spirulina traditional Chinese medicine composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105250397A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106063860A (en) * | 2016-06-08 | 2016-11-02 | 广州国宇医药科技有限公司 | A kind of Aloe Chinese medicine composition |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1919217A (en) * | 2006-06-22 | 2007-02-28 | 上海健治一号高科技有限公司 | Capsule made of ant extract, spirulina platensis dry powder and chinese caterpillar fungus extract |
-
2015
- 2015-09-22 CN CN201510646993.4A patent/CN105250397A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1919217A (en) * | 2006-06-22 | 2007-02-28 | 上海健治一号高科技有限公司 | Capsule made of ant extract, spirulina platensis dry powder and chinese caterpillar fungus extract |
Non-Patent Citations (2)
| Title |
|---|
| 娄俊东等: "张鸣鹤治疗骨关节炎经验浅析", 《社区医学杂志》 * |
| 陈东林: "螺旋藻的生物化学分析及开发利用价值研究", 《宜宾师专学报（自然版）》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106063860A (en) * | 2016-06-08 | 2016-11-02 | 广州国宇医药科技有限公司 | A kind of Aloe Chinese medicine composition |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101229355B (en) | Rheumatism soup | |
| CN104225428A (en) | Chinese medicine for treating cold-dampness blockage scapulohumeral periarthritis and preparation method thereof | |
| CN101181568B (en) | Traditional chinese medicine preparation for curing osteoproliferation as well as arthrosis ache | |
| CN103505659A (en) | Chinese proprietary medicine for treating rheumatoid arthritis | |
| CN102657736B (en) | Medicament composition for treating rheumatoid arthritis and preparation method of medicament composition | |
| CN104189463A (en) | Rheumatism pain medicinal liquor and preparation method thereof | |
| CN104027684A (en) | Traditional Chinese medicinal composition for treating gout and preparation method thereof | |
| CN104337989A (en) | Traditional Chinese medicine composition containing centipeda minima and frankincense for treating gout | |
| CN103690673A (en) | Formula capsules for treating rheumatism | |
| CN105250397A (en) | Spirulina traditional Chinese medicine composition | |
| CN106511905A (en) | Traditional Chinese medicine preparation used for curing cervical spondylosis and preparation method thereof | |
| CN103495103B (en) | Medicament for promoting digestion and strengthening spleen | |
| CN103041320B (en) | Traditional Chinese medicine composition for treating cervical spondylosis and preparation method thereof | |
| CN102579672A (en) | Medicament for treating bone hyperplasia and lumbar disc herniation | |
| CN112472776A (en) | Traditional Chinese medicine pill for treating gout and preparation method thereof | |
| CN102526384B (en) | Medicament for treating rheumatism and preparation method thereof | |
| CN105311210A (en) | Pharmaceutical composition for treating rheumatoid bone diseases | |
| CN103520282B (en) | Traditional Chinese medicine composition for treating osteoarthritis and preparation method thereof | |
| CN102370838B (en) | Kidney-invigorating and tendon-reinforcing double-phase capsule | |
| CN102335304B (en) | Chinese medicine composition for dispelling wind, removing dampness, invigorating blood circulation, and relieving pain and preparation method thereof | |
| CN105327024A (en) | Traditional Chinese medicine preparation for treating rheumatoid arthritis | |
| CN106063860A (en) | A kind of Aloe Chinese medicine composition | |
| CN106853193A (en) | It is a kind of to treat Chinese medicine of rheumatoid arthritis and preparation method thereof | |
| CN104645079A (en) | Traditional Chinese medicine for treating post-stroke limb numbness | |
| CN104208134A (en) | Traditional Chinese medicine pill for treating facial paralysis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160120 |