CN105311210A - Pharmaceutical composition for treating rheumatoid bone diseases - Google Patents
Pharmaceutical composition for treating rheumatoid bone diseases Download PDFInfo
- Publication number
- CN105311210A CN105311210A CN201510874655.6A CN201510874655A CN105311210A CN 105311210 A CN105311210 A CN 105311210A CN 201510874655 A CN201510874655 A CN 201510874655A CN 105311210 A CN105311210 A CN 105311210A
- Authority
- CN
- China
- Prior art keywords
- weight portion
- radix
- weight portions
- weight
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 28
- 208000020084 Bone disease Diseases 0.000 title abstract 3
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract description 44
- 239000004863 Frankincense Substances 0.000 claims abstract description 22
- 229960003080 taurine Drugs 0.000 claims abstract description 22
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 21
- 229920000615 alginic acid Polymers 0.000 claims abstract description 21
- 150000004781 alginic acids Chemical class 0.000 claims abstract description 21
- 229960005080 warfarin Drugs 0.000 claims abstract description 21
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229960001126 alginic acid Drugs 0.000 claims abstract description 19
- 239000000783 alginic acid Substances 0.000 claims abstract description 19
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 238000001914 filtration Methods 0.000 claims description 40
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
- 241000628997 Flos Species 0.000 claims description 26
- 208000025747 Rheumatic disease Diseases 0.000 claims description 23
- 230000000552 rheumatic effect Effects 0.000 claims description 23
- 241000659088 Alchorneae Species 0.000 claims description 21
- 241000717739 Boswellia sacra Species 0.000 claims description 21
- 235000005739 manihot Nutrition 0.000 claims description 21
- 210000000582 semen Anatomy 0.000 claims description 21
- 239000007788 liquid Substances 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 14
- 239000004615 ingredient Substances 0.000 claims description 12
- 238000005352 clarification Methods 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 8
- 230000006837 decompression Effects 0.000 claims description 8
- 239000012153 distilled water Substances 0.000 claims description 8
- 238000001704 evaporation Methods 0.000 claims description 8
- 230000008020 evaporation Effects 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 8
- 239000012467 final product Substances 0.000 claims description 8
- 238000004064 recycling Methods 0.000 claims description 8
- 238000010992 reflux Methods 0.000 claims description 8
- 229910001220 stainless steel Inorganic materials 0.000 claims description 8
- 239000010935 stainless steel Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 239000010409 thin film Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 241000221022 Manihot Species 0.000 claims 4
- 230000000694 effects Effects 0.000 abstract description 41
- 239000003814 drug Substances 0.000 abstract description 26
- 208000002193 Pain Diseases 0.000 abstract description 22
- 230000036407 pain Effects 0.000 abstract description 22
- 210000004369 blood Anatomy 0.000 abstract description 20
- 239000008280 blood Substances 0.000 abstract description 20
- 210000004185 liver Anatomy 0.000 abstract description 10
- 210000003205 muscle Anatomy 0.000 abstract description 9
- 230000001737 promoting effect Effects 0.000 abstract description 9
- 230000017531 blood circulation Effects 0.000 abstract description 8
- 210000003734 kidney Anatomy 0.000 abstract description 8
- 210000002435 tendon Anatomy 0.000 abstract description 7
- 210000000988 bone and bone Anatomy 0.000 abstract description 6
- 229940079593 drug Drugs 0.000 abstract description 4
- 210000004072 lung Anatomy 0.000 abstract description 3
- 238000005728 strengthening Methods 0.000 abstract description 3
- 230000008961 swelling Effects 0.000 abstract description 3
- 238000000605 extraction Methods 0.000 abstract description 2
- 244000052769 pathogen Species 0.000 abstract description 2
- 239000000047 product Substances 0.000 abstract description 2
- 230000002040 relaxant effect Effects 0.000 abstract description 2
- 241001075517 Abelmoschus Species 0.000 abstract 1
- 240000000662 Anethum graveolens Species 0.000 abstract 1
- 235000003717 Boswellia sacra Nutrition 0.000 abstract 1
- 240000007551 Boswellia serrata Species 0.000 abstract 1
- 235000012035 Boswellia serrata Nutrition 0.000 abstract 1
- 244000080208 Canella winterana Species 0.000 abstract 1
- 235000008499 Canella winterana Nutrition 0.000 abstract 1
- 235000002566 Capsicum Nutrition 0.000 abstract 1
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 241000123589 Dipsacus Species 0.000 abstract 1
- 241000501743 Gentiana macrophylla Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 241001506304 Kadsura japonica Species 0.000 abstract 1
- 241000212322 Levisticum officinale Species 0.000 abstract 1
- 241000721690 Lythrum salicaria Species 0.000 abstract 1
- 239000006002 Pepper Substances 0.000 abstract 1
- 235000016761 Piper aduncum Nutrition 0.000 abstract 1
- 235000017804 Piper guineense Nutrition 0.000 abstract 1
- 244000203593 Piper nigrum Species 0.000 abstract 1
- 235000008184 Piper nigrum Nutrition 0.000 abstract 1
- 244000272264 Saussurea lappa Species 0.000 abstract 1
- 235000006784 Saussurea lappa Nutrition 0.000 abstract 1
- 241000951473 Schizonepeta Species 0.000 abstract 1
- 244000178320 Vaccaria pyramidata Species 0.000 abstract 1
- 235000010587 Vaccaria pyramidata Nutrition 0.000 abstract 1
- 244000178289 Verbascum thapsus Species 0.000 abstract 1
- 235000010599 Verbascum thapsus Nutrition 0.000 abstract 1
- 229940017545 cinnamon bark Drugs 0.000 abstract 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 abstract 1
- 239000001645 levisticum officinale Substances 0.000 abstract 1
- 239000013589 supplement Substances 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 description 21
- 235000019634 flavors Nutrition 0.000 description 21
- 240000003183 Manihot esculenta Species 0.000 description 17
- 239000000243 solution Substances 0.000 description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- 201000010099 disease Diseases 0.000 description 9
- 206010034464 Periarthritis Diseases 0.000 description 7
- 208000024891 symptom Diseases 0.000 description 7
- 206010028391 Musculoskeletal Pain Diseases 0.000 description 6
- 208000007613 Shoulder Pain Diseases 0.000 description 6
- 230000003110 anti-inflammatory effect Effects 0.000 description 5
- 241000282414 Homo sapiens Species 0.000 description 4
- 208000004044 Hypesthesia Diseases 0.000 description 4
- 206010041591 Spinal osteoarthritis Diseases 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 208000034783 hypoesthesia Diseases 0.000 description 4
- 230000001939 inductive effect Effects 0.000 description 4
- 208000014674 injury Diseases 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 231100000862 numbness Toxicity 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 208000006820 Arthralgia Diseases 0.000 description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 2
- 208000007101 Muscle Cramp Diseases 0.000 description 2
- 206010028289 Muscle atrophy Diseases 0.000 description 2
- 208000008765 Sciatica Diseases 0.000 description 2
- 208000026137 Soft tissue injury Diseases 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 229960001138 acetylsalicylic acid Drugs 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000003356 anti-rheumatic effect Effects 0.000 description 2
- 239000003435 antirheumatic agent Substances 0.000 description 2
- 230000037444 atrophy Effects 0.000 description 2
- 208000036319 cervical spondylosis Diseases 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000001506 immunosuppresive effect Effects 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000002175 menstrual effect Effects 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 201000000585 muscular atrophy Diseases 0.000 description 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 201000003068 rheumatic fever Diseases 0.000 description 2
- 208000005801 spondylosis Diseases 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- LJRDOKAZOAKLDU-UDXJMMFXSA-N (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO LJRDOKAZOAKLDU-UDXJMMFXSA-N 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 206010002027 Amyotrophy Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 206010005963 Bone formation increased Diseases 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
- 229930105110 Cyclosporin A Natural products 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 208000007875 Femur Head Necrosis Diseases 0.000 description 1
- 208000001640 Fibromyalgia Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 206010050031 Muscle strain Diseases 0.000 description 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 206010033425 Pain in extremity Diseases 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- 201000002661 Spondylitis Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 208000019667 acute articular rheumatism Diseases 0.000 description 1
- 239000003470 adrenal cortex hormone Substances 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 description 1
- 229960002170 azathioprine Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 229960003677 chloroquine Drugs 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 208000035850 clinical syndrome Diseases 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 229960004397 cyclophosphamide Drugs 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 229960001259 diclofenac Drugs 0.000 description 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- -1 golden preparation Chemical compound 0.000 description 1
- 210000002149 gonad Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 description 1
- 229960004171 hydroxychloroquine Drugs 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 230000006028 immune-suppresssive effect Effects 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 description 1
- 229960000681 leflunomide Drugs 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 229960002009 naproxen Drugs 0.000 description 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 229960001639 penicillamine Drugs 0.000 description 1
- 208000011906 peptic ulcer disease Diseases 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 229960002702 piroxicam Drugs 0.000 description 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 150000003873 salicylate salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 210000003497 sciatic nerve Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 1
- 229960001940 sulfasalazine Drugs 0.000 description 1
- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the technical field of medicines, and in particular relates to a pharmaceutical composition for treating rheumatoid bone diseases. The pharmaceutical composition for treating the rheumatoid bone diseases is mainly prepared from the following components: incised notopterygium rhizome, seed of dill, root of largeleaf gentian, kadsura pepper stem, flower of sunset abelmoschus, shaved cinnamon bark, purple lythrum, Szechuan lovage rhizome, frankincense, costus root, fried licorice root, all-grass of twocolor velvetplant, fineleaf schizonepeta herb, Himalayan teasel root, green tangerine peel, cowherb seed, warfarin, taurine and alginic acid. The pharmaceutical composition provided by the invention is prepared from more medicines and is wide in coverage range, and all the traditional Chinese medicine raw materials are reasonable in compatibility and supplement each other in medicine effect to bring out the best in each other; by nourishing the liver and kidneys, strengthening tendons and bones, recuperating the heart and lung and eliminating pathogens to support healthy qi, the effects of reducing swelling and relieving pain, expelling wind and removing dampness, clearing heat and dispelling coldness, relaxing muscles and tendons to remove obstruction in collaterals as well as promoting blood circulation to dispel blood stasis are achieved; and furthermore, the pharmaceutical composition is prepared by adopting a modern extraction process, so that the quality and curative effect of the product are ensured.
Description
Technical field
The present invention relates to medical art, be specifically related to a kind of pharmaceutical composition for the treatment of rheumatic osteopathia.
Background technology
Orthopaedic disease, as a medical circle difficult problem, receives much attention always, belongs to the category of Chinese medicine arthromyodynia, the injury of tendon and muscle.Mainly comprise modern medicine acute or chronic soft tissue injury, hyperosteogeny, rheumatalgia, cervical spondylosis, lumbar spondylosis, scapulohumeral periarthritis, lumbar muscle strain, sciatica etc.
The disease such as neck, shoulder, brachialgia of cervical spondylosis, lumbar spondylosis, scapulohumeral periarthritis is included in motherland's medical science arthromyodynia more, and the traditional Chinese medical science is thought, primary disease system affection of exogenous wind-cold damp, retardance meridians, so that QI and blood resistance is closed obstructed, stagnation of QI and blood may bring about pain.QI and blood blocks then passages through which vital energy circulates and loses foster, dizzy headache occurs, upper limb numbness etc.Rheumatalgia (also claiming rheumatism) is trembled with fear as one group of primary symptom extremely common clinical syndrome with arthralgia, anemophobia.In the patient of rheumatism immunity section outpatient clinic, quite a few is had to be rheumatalgia patient.Rheumatalgia belongs to arthromyodynia (numbness disease or traditional Chinese medical science rheumatism) category.Acute and chronic soft tissue injury all belongs to Chinese medicine injury of tendon and muscle category.Etiology and pathogenesis mainly external force is caused injury muscles, and venation is damaged, and blood is from through forming the stasis of blood, and the stasis of blood and heat-transformation are for suffering from.Clinically with blood circulation promoting and blood stasis dispelling, channels sootheing and network vessel quickening, reducing swelling and alleviating pain is main method for the treatment of.Sciatica refers to the disease along there is pain in sciatic nerve path and areal area thereof, and the traditional Chinese medical science claims " muscular rheumatism ".
The medicine for the treatment of rheumatism can be divided into following a few class:
1. nonsteroidal anti-inflammatory agent (NSAIDs): the effect of this type of medicine, is mainly antipyretic, antiinflammatory and analgesia, and reach reduce inflammation reaction and object.Be that aspirin (aspirin) is so far still for treating the active drug of acute rheumatic fever and rheumatic arthritis the earliest.Produced various Salicylates afterwards, conventional has ibuprofen, diclofenac, indomethacin, piroxicam, naproxen etc., but the pharmacokinetics of various medicine and untoward reaction different, main to gastrointestinal, kidney, liver and blood system, must note dosage during use, usage, side effect etc.
2. adrenocortical hormone: mainly refer to glucocorticoid, because this kind of medicine has antiinflammatory and immunosuppressive action, has more by force and diminishes inflammation fast and various symptoms that inflammatory reaction brings, as heating, and arthroncus and pain.So to various rheumatism, be often used as First Line medicine.Having of applying clinically is fugitive, middle effect and the preparation such as long-acting.Usage has oral, muscle or intraarticular injection, intravenous injection, can according to disease kind, and the state of an illness does different selections.But because it not effects a radical cure medicine, long-term a large amount of use can bring out infection, osteoporosis, femur head necrosis, diabetes, peptic ulcer, hypertension, psychological problem etc.; And easy generation state of an illness rebound phenomenon as too fast in drug withdrawal, therefore should note according to disease kind and the state of an illness, regulate the kind and dosage that use medicine.Except patient with severe symptoms, in principle with low dose, Low doses is advisable.
3. the antirheumatic (DMARDs) improving the state of an illness is also called and acts on antirheumatic slowly.It is different that this type of medicine comprises numerous species structure, acts on different medicine.Their general character is that onset is slow, has certain cumulative action, therefore after drug withdrawal, event resolves is also comparatively slow, still can maintain a period of time.They there is no direct anti-inflammatory analgetic effect, but can play antiinflammatory and immune or immunosuppressive action by different mechanism.Thus, also can improve arthroncus, pain, stiff and mitigation system symptom, reduce acute phase reactive protein, erythrocyte sedimentation rate.As service time is longer, also other immune indexes can be improved, as RF, ANA etc.The irradiation image that still can make had improves.The medicine of DMARDs class includes antimalarial-chloroquine, oxychloroquine, sulfasalazine, methotrexate, azathioprine, cyclophosphamide, penicillamine, golden preparation, ciclosporin A and leflunomide.
, there is more problem in the internal organs (liver, kidney, bladder, lung, gastrointestinal, gonad) wanted body weight for humans of various medicine and tissue (bone marrow) toxic action of having nothing in common with each other above.
In current existing technology, western medical treatment primary disease often with anti-inflammatory analgetic, hormone, close, ultraviolet radiation, traction, the method such as operation.Its shortcoming is cured the symptoms, not the disease, and treatment time is long, weak curative effect, and expense is large, and surgical risk is high.The traditional Chinese medical science adopts Chinese medicine for oral administration, with the method such as relaxing muscles and tendons and activating QI and blood in the collateral, blood circulation promoting and blood stasis dispelling, but DeGrain, or just clothes are effectively subsequently then without effect, and curative effect is not lasting, and relapse rate is high.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, devise a kind of pharmaceutical composition for the treatment of rheumatic osteopathia of Integrated TCM, the present invention is used for the treatment of the diseases such as rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, spondylitis and lumbago and skelalgia, and instant effect, short treating period, cure rate are high.
Technical scheme of the present invention is as follows:
The pharmaceutical composition for the treatment of rheumatic osteopathia, it is characterized in that: formulated primarily of following ingredients, the Rhizoma Et Radix Notopterygii of 40-60 weight portion, the Fructus anethi of 40-60 weight portion, the Radix Gentianae Macrophyllae of 40-60 weight portion, the Caulis Piperis Kadsurae of 80-120 weight portion, the Flos abelmoschi manihot of 120-130 weight portion, the Cortex Cinnamomi of 20-30 weight portion, the Herba Lythri Salicariae of 120-130 weight portion, the Rhizoma Chuanxiong of 50-60 weight portion, the Olibanum of 60-70 weight portion, the Radix Aucklandiae of 60-70 weight portion, the Radix Glycyrrhizae Preparata of 20-30 weight portion, the Radix seu Folium Alchorneae trewioidis of 30-40 weight portion, the Herba Schizonepetae of 10-20 weight portion, the Radix Dipsaci of 15-30 weight portion, the Pericarpium Citri Reticulatae Viride of 5-10 weight portion, the Semen Vaccariae of 25-40 weight portion, the warfarin of 0.5-2 weight portion, the taurine of 1-3 weight portion, the alginic acid of 1-2 weight portion.
Preferably, the pharmaceutical composition for the treatment of rheumatic osteopathia, formulated primarily of following ingredients, the Rhizoma Et Radix Notopterygii of 48-55 weight portion, the Fructus anethi of 45-50 weight portion, the Radix Gentianae Macrophyllae of 50-52 weight portion, the Caulis Piperis Kadsurae of 90-100 weight portion, the Flos abelmoschi manihot of 125-130 weight portion, the Cortex Cinnamomi of 20-25 weight portion, the Herba Lythri Salicariae of 120-125 weight portion, the Rhizoma Chuanxiong of 55-60 weight portion, the Olibanum of 60-70 weight portion, the Radix Aucklandiae of 65-70 weight portion, the Radix Glycyrrhizae Preparata of 20-25 weight portion, the Radix seu Folium Alchorneae trewioidis of 30-35 weight portion, the Herba Schizonepetae of 10-15 weight portion, the Radix Dipsaci of 20-25 weight portion, the Pericarpium Citri Reticulatae Viride of 5-10 weight portion, the Semen Vaccariae of 30-35 weight portion, the warfarin of 0.5-1 weight portion, 1.5-2 measures the taurine of part, 1.5-1.8 the alginic acid of weight portion.
Further, the pharmaceutical composition of described treatment rheumatic osteopathia, also comprises the Cortex Acanthopancis of the Radix Achyranthis Bidentatae of 10-15 weight portion, 20-30 weight portion.
Further, the pharmaceutical composition of the treatment rheumatic osteopathia as described in claim 1 or 3 any one, also comprises the 20-25 weight portion Cortex Eucommiae, the Flos Carthami of 30-45 weight portion and the Fructus Aurantii of 20-40 weight portion.
Further, the pharmaceutical composition for the treatment of rheumatic osteopathia, formulated primarily of following ingredients, the Rhizoma Et Radix Notopterygii of 51 weight portions, the Fructus anethi of 47 weight portions, the Radix Gentianae Macrophyllae of 50 weight portions, the Caulis Piperis Kadsurae of 95 weight portions, the Flos abelmoschi manihot of 126 weight portions, the Cortex Cinnamomi of 23 weight portions, the Herba Lythri Salicariae of 120 weight portions, the Rhizoma Chuanxiong of 56 weight portions, the Olibanum of 65 weight portions, the Radix Aucklandiae of 65 weight portions, the Radix Glycyrrhizae Preparata of 20 weight portions, the Radix seu Folium Alchorneae trewioidis of 33 weight portions, the Herba Schizonepetae of 12 weight portions, the Radix Dipsaci of 22 weight portions, the Pericarpium Citri Reticulatae Viride of 8 weight portions, the Semen Vaccariae of 30 weight portions, the warfarin of 0.8 weight portion, the taurine of 1.5 weight portions, the alginic acid of 1.5 weight portions.
Prepare a method for the pharmaceutical composition of the treatment rheumatic osteopathia as described in claim 1-5, it is characterized in that:
(1) get the Rhizoma Et Radix Notopterygii of formula ratio, be crushed to 50 ~ 60 orders, add 10 times amount distilled water, heated and boiled 1.5 ~ 2 hours, cooling centrifugal filtering, filtering residue heated and boiled 0.5 ~ 1 hour again, centrifugal filtering; It is the ethanol of 65 ~ 80% that filtering residue adds 2 times amount concentration, reflux, extract, 3 ~ 6 hours, centrifugal filtering, 2 ~ 3 times repeatedly, merge above all filtrate, decompression recycling ethanol, be concentrated into through thin film evaporation the liquid that relative density is the clarification of 0.6-0.7, obtain Rhizoma Et Radix Notopterygii extracting solution, stand-by;
(2) Fructus anethi of formula ratio, Radix Gentianae Macrophyllae, Caulis Piperis Kadsurae, Flos abelmoschi manihot, Cortex Cinnamomi, Herba Lythri Salicariae, Rhizoma Chuanxiong, Olibanum, the Radix Aucklandiae, Radix Glycyrrhizae Preparata, Radix seu Folium Alchorneae trewioidis, Herba Schizonepetae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Semen Vaccariae is got respectively, respectively according to the extracting method of above-mentioned Rhizoma Et Radix Notopterygii, obtain the extracting solution of each raw material, stand-by;
(3) said extracted liquid is put into stainless steel cask, add 52 degree of Chinese liquor, finally add the warfarin of formula ratio, taurine, alginic acid, stir, after ultrasonic disperse and get final product.
In sum, the present invention has following beneficial effect:
The present invention selects medicine many, wide coverage, and each raw material of Chinese medicine compatibility is scientific and reasonable, and drug effect complements each other, and brings out the best in each other; Effect of reducing swelling and alleviating pain, expelling wind and removing dampness, heat clearing away cold expelling, channels sootheing and network vessel quickening and blood circulation promoting and blood stasis dispelling is reached by nourishing the liver and kidney, strong muscles and bones, regulation of mental activities reason lung, eliminating pathogenic factor for supporting vital QI; Further; the present invention adopts modern extraction process; ensure that quality and the curative effect of product; further, the medicament adding anticoagulant in the present invention, to improve the mobile performance of blood, better ensure that the mobility of blood; the taurine simultaneously added further can improve function of human body; improve the human body immunity of period in a medicine, also can prevent platelet aggregation simultaneously, reduce blood fat.
The pharmacologically active of each medicine of the present invention is as follows:
Rhizoma Et Radix Notopterygii, [nature and flavor] acrid in the mouth, hardship, warm in nature; [effect] falls apart exterior cold; Wind-damp dispelling; Profit joint; Pain relieving; Main affection of exogenous wind-cold; Have a headache lossless; Edema due to wind pathogen edema; Sore swollen toxin.
Fructus anethi, [nature and flavor] acrid in the mouth, hardship, slightly warm in nature; [effect] expelling wind and removing dampness, arthralgia aggravated by cold pain relieving.
Radix Gentianae Macrophyllae, [nature and flavor] are pungent, bitter, flat; [effect] wind-damp dispelling, clearing away damp-heat, stopping numbness pain.
Caulis Piperis Kadsurae, [nature and flavor] acrid in the mouth, hardship, slightly warm in nature; [effect] wind-damp dispelling, the meridian dredging, stopping numbness pain.
Flos abelmoschi manihot, [nature and flavor] bitter in the mouth, micro-pungent, property are put down; [effect] clearing heat and expelling damp dredging collateral.
Cortex Cinnamomi, [nature and flavor] are pungent, sweet, hot; [effect] replenishing vital essence to improve eyesight, repercussive granulation promoting, mends impairment caused by overstrain, warm waist knee joint, reuniting the fractured tendons and bones.
Herba Lythri Salicariae, [nature and flavor] are sweet, pungent, warm; [effect] enriches blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.
Rhizoma Chuanxiong, [nature and flavor] are pungent, temperature; [effect] enters liver, gallbladder meridian.
Olibanum, [nature and flavor] acrid, bitter, warm; The pain relieving of [effect] blood-activating and qi-promoting, detumescence and promoting granulation.
The Radix Aucklandiae, [nature and flavor] pungent acrid in the mouth, hardship, warm in nature; [effect] circulation of qi promoting, pain relieving, spleen invigorating, helps digestion.
Radix Glycyrrhizae Preparata, [nature and flavor] put down; [effect] heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen.
Radix seu Folium Alchorneae trewioidis, [nature and flavor] acrid in the mouth, sweet, slightly warm in nature; [effect] expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.
Herba Schizonepetae, [nature and flavor] acrid in the mouth, micro-hardship, slightly warm in nature; [effect] dispels the wind; Induce sweat; Rash; Hemostasis.
Radix Dipsaci, [nature and flavor] are warm in nature, bitter in the mouth, pungent; [effect] invigorating the liver and kidney, reuniting the fractured tendons and bones, blood circulation regulating.
Pericarpium Citri Reticulatae Viride, [nature and flavor] bitter in the mouth, pungent, warm in nature; [effect] has soothing the liver dispelling the stagnated QI, effect that removing food stagnancyization is stagnant.
Radix Achyranthis Bidentatae, [nature and flavor] are bitter, sweet, sour, flat; [effect] eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards.
Cortex Acanthopancis [nature and flavor] acrid in the mouth, hardship, warm in nature; [effect] has wind-damp dispelling, liver and kidney tonifying, bone and muscle strengthening, the effect of inducing diuresis to remove edema.
The Cortex Eucommiae [nature and flavor] acrid in the mouth, flat, temperature, nontoxic; [effect] Cortex Eucommiae has invigorating the liver and kidney, and control spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, hypertension, antiabortive effect.
Flos Carthami [nature and flavor] is pungent, warm; [effect] promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving.Control amenorrhea, lump in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, injury from falling down.
Fructus Aurantii, [nature and flavor] property is bitter, pungent, sour, warm; [effect] dispelling the stagnated QI, row expectorant, removing food stagnancy.
Semen Vaccariae, [nature and flavor] feeble QI, taste are micro-puckery, bitter; The detumescence of [effect] promoting blood circulation to restore menstrual flow, stimulating milk secretion, inducing diuresis for treating stranguria syndrome.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention will be described in detail:
Embodiment 1
The pharmaceutical composition for the treatment of rheumatic osteopathia, formulated primarily of following ingredients, the Rhizoma Et Radix Notopterygii of 40 weight portions, the Fructus anethi of 40 weight portions, the Radix Gentianae Macrophyllae of 40 weight portions, the Caulis Piperis Kadsurae of 80 weight portions, the Flos abelmoschi manihot of 120 weight portions, the Cortex Cinnamomi of 20 weight portions, the Herba Lythri Salicariae of 120 weight portions, the Rhizoma Chuanxiong of 50 weight portions, the Olibanum of 60 weight portions, the Radix Aucklandiae of 60 weight portions, the Radix Glycyrrhizae Preparata of 20 weight portions, the Radix seu Folium Alchorneae trewioidis of 30 weight portions, the Herba Schizonepetae of 10 weight portions, the Radix Dipsaci of 15 weight portions, the Pericarpium Citri Reticulatae Viride of 5 weight portions, the Semen Vaccariae of 25 weight portions, the warfarin of 0.5 weight portion, the taurine of 1 weight portion, 1 weight portion alginic acid.
(1) get the Rhizoma Et Radix Notopterygii of formula ratio, be crushed to 50 orders, add 10 times amount distilled water, heated and boiled 1.5 hours, cooling centrifugal filtering, filtering residue heated and boiled 0.5 hour again, centrifugal filtering; It is the ethanol of 65% that filtering residue adds 2 times amount concentration, reflux, extract, 3 hours, centrifugal filtering, 2 times repeatedly, and merge above all filtrate, decompression recycling ethanol, is concentrated into through thin film evaporation the liquid that relative density is the clarification of 0.6, obtains Rhizoma Et Radix Notopterygii extracting solution, stand-by;
(2) Fructus anethi of formula ratio, Radix Gentianae Macrophyllae, Caulis Piperis Kadsurae, Flos abelmoschi manihot, Cortex Cinnamomi, Herba Lythri Salicariae, Rhizoma Chuanxiong, Olibanum, the Radix Aucklandiae, Radix Glycyrrhizae Preparata, Radix seu Folium Alchorneae trewioidis, Herba Schizonepetae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Semen Vaccariae is got respectively, respectively according to the extracting method of above-mentioned Rhizoma Et Radix Notopterygii, obtain the extracting solution of each raw material, stand-by;
(3) said extracted liquid is put into stainless steel cask, add 52 degree of Chinese liquor, finally add the warfarin of formula ratio, taurine, alginic acid, stir, after ultrasonic disperse and get final product.
Embodiment 2
The pharmaceutical composition for the treatment of rheumatic osteopathia, formulated primarily of following ingredients, the Rhizoma Et Radix Notopterygii of 60 weight portions, the Fructus anethi of 60 weight portions, the Radix Gentianae Macrophyllae of 60 weight portions, the Caulis Piperis Kadsurae of 120 weight portions, the Flos abelmoschi manihot of 130 weight portions, the Cortex Cinnamomi of 30 weight portions, the Herba Lythri Salicariae of 130 weight portions, the Rhizoma Chuanxiong of 60 weight portions, the Olibanum of 70 weight portions, the Radix Aucklandiae of 70 weight portions, the Radix Glycyrrhizae Preparata of 30 weight portions, the Radix seu Folium Alchorneae trewioidis of 40 weight portions, the Herba Schizonepetae of 20 weight portions, the Radix Dipsaci of 30 weight portions, the Pericarpium Citri Reticulatae Viride of 10 weight portions, the Semen Vaccariae of 40 weight portions, the warfarin of 2 weight portions, the taurine of 3 weight portions, the alginic acid of 3 weight portions.
(1) get the Rhizoma Et Radix Notopterygii of formula ratio, be crushed to 60 orders, add 10 times amount distilled water, heated and boiled 2 hours, cooling centrifugal filtering, filtering residue heated and boiled 1 hour again, centrifugal filtering; It is the ethanol of 80% that filtering residue adds 2 times amount concentration, reflux, extract, 6 hours, centrifugal filtering, 3 times repeatedly, and merge above all filtrate, decompression recycling ethanol, is concentrated into through thin film evaporation the liquid that relative density is the clarification of 0.7, obtains Rhizoma Et Radix Notopterygii extracting solution, stand-by;
(2) Fructus anethi of formula ratio, Radix Gentianae Macrophyllae, Caulis Piperis Kadsurae, Flos abelmoschi manihot, Cortex Cinnamomi, Herba Lythri Salicariae, Rhizoma Chuanxiong, Olibanum, the Radix Aucklandiae, Radix Glycyrrhizae Preparata, Radix seu Folium Alchorneae trewioidis, Herba Schizonepetae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Semen Vaccariae is got respectively, respectively according to the extracting method of above-mentioned Rhizoma Et Radix Notopterygii, obtain the extracting solution of each raw material, stand-by;
(3) said extracted liquid is put into stainless steel cask, add 52 degree of Chinese liquor, finally add the warfarin of formula ratio, taurine, 3 alginic acids, stir, after ultrasonic disperse and get final product.
Embodiment 3
The pharmaceutical composition for the treatment of rheumatic osteopathia, formulated primarily of following ingredients, the Rhizoma Et Radix Notopterygii of 48 weight portions, the Fructus anethi of 45 weight portions, the Radix Gentianae Macrophyllae of 50 weight portions, the Caulis Piperis Kadsurae of 90 weight portions, the Flos abelmoschi manihot of 125 weight portions, the Cortex Cinnamomi of 20 weight portions, the Herba Lythri Salicariae of 120 weight portions, the Rhizoma Chuanxiong of 55 weight portions, the Olibanum of 60 weight portions, the Radix Aucklandiae of 65 weight portions, the Radix Glycyrrhizae Preparata of 20 weight portions, the Radix seu Folium Alchorneae trewioidis of 30 weight portions, the Herba Schizonepetae of 10 weight portions, the Radix Dipsaci of 20 weight portions, the Pericarpium Citri Reticulatae Viride of 5 weight portions, the Semen Vaccariae of 30 weight portions, the warfarin of 0.5 weight portion, the taurine of 1.5 weight portions, the alginic acid of 1.5 weight portions.
(1) get the Rhizoma Et Radix Notopterygii of formula ratio, be crushed to 55 orders, add 10 times amount distilled water, heated and boiled 2 hours, cooling centrifugal filtering, filtering residue heated and boiled 1 hour again, centrifugal filtering; It is the ethanol of 80% that filtering residue adds 2 times amount concentration, reflux, extract, 6 hours, centrifugal filtering, 3 times repeatedly, and merge above all filtrate, decompression recycling ethanol, is concentrated into through thin film evaporation the liquid that relative density is the clarification of 0.7, obtains Rhizoma Et Radix Notopterygii extracting solution, stand-by;
(2) Fructus anethi of formula ratio, Radix Gentianae Macrophyllae, Caulis Piperis Kadsurae, Flos abelmoschi manihot, Cortex Cinnamomi, Herba Lythri Salicariae, Rhizoma Chuanxiong, Olibanum, the Radix Aucklandiae, Radix Glycyrrhizae Preparata, Radix seu Folium Alchorneae trewioidis, Herba Schizonepetae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Semen Vaccariae is got respectively, respectively according to the extracting method of above-mentioned Rhizoma Et Radix Notopterygii, obtain the extracting solution of each raw material, stand-by;
(3) said extracted liquid is put into stainless steel cask, add 52 degree of Chinese liquor, finally add the warfarin of formula ratio, taurine, alginic acid, stir, after ultrasonic disperse and get final product.
Embodiment 4
The pharmaceutical composition for the treatment of rheumatic osteopathia, formulated primarily of following ingredients, the Rhizoma Et Radix Notopterygii of 55 weight portions, the Fructus anethi of 50 weight portions, the Radix Gentianae Macrophyllae of 52 weight portions, the Caulis Piperis Kadsurae of 100 weight portions, the Flos abelmoschi manihot of 130 weight portions, the Cortex Cinnamomi of 25 weight portions, the Herba Lythri Salicariae of 125 weight portions, the Rhizoma Chuanxiong of 60 weight portions, the Olibanum of 70 weight portions, the Radix Aucklandiae of 70 weight portions, the Radix Glycyrrhizae Preparata of 25 weight portions, the Radix seu Folium Alchorneae trewioidis of 35 weight portions, the Herba Schizonepetae of 15 weight portions, the Radix Dipsaci of 25 weight portions, the Pericarpium Citri Reticulatae Viride of 10 weight portions, the Semen Vaccariae of 35 weight portions, the warfarin of 1 weight portion, the taurine of 2 weight portions, 2 weight portion alginic acids.
Further, the pharmaceutical composition of described treatment rheumatic osteopathia, also comprises the Cortex Acanthopancis of the Radix Achyranthis Bidentatae of 10 weight portions, 20 weight portions.
(1) get the Rhizoma Et Radix Notopterygii of formula ratio, be crushed to 55 orders, add 10 times amount distilled water, heated and boiled 2 hours, cooling centrifugal filtering, filtering residue heated and boiled 1 hour again, centrifugal filtering; It is the ethanol of 80% that filtering residue adds 2 times amount concentration, reflux, extract, 6 hours, centrifugal filtering, 3 times repeatedly, and merge above all filtrate, decompression recycling ethanol, is concentrated into through thin film evaporation the liquid that relative density is the clarification of 0.7, obtains Rhizoma Et Radix Notopterygii extracting solution, stand-by;
(2) Fructus anethi of formula ratio, Radix Gentianae Macrophyllae, Caulis Piperis Kadsurae, Flos abelmoschi manihot, Cortex Cinnamomi, Herba Lythri Salicariae, Rhizoma Chuanxiong, Olibanum, the Radix Aucklandiae, Radix Glycyrrhizae Preparata, Radix seu Folium Alchorneae trewioidis, Herba Schizonepetae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Semen Vaccariae, Radix Achyranthis Bidentatae, Cortex Acanthopancis is got respectively, respectively according to the extracting method of above-mentioned Rhizoma Et Radix Notopterygii, obtain the extracting solution of each raw material, stand-by;
(3) said extracted liquid is put into stainless steel cask, add 52 degree of Chinese liquor, finally add the warfarin of formula ratio, taurine, alginic acid, stir, after ultrasonic disperse and get final product.
Embodiment 5
The pharmaceutical composition for the treatment of rheumatic osteopathia, formulated primarily of following ingredients, the Rhizoma Et Radix Notopterygii of 55 weight portions, the Fructus anethi of 50 weight portions, the Radix Gentianae Macrophyllae of 52 weight portions, the Caulis Piperis Kadsurae of 100 weight portions, the Flos abelmoschi manihot of 130 weight portions, the Cortex Cinnamomi of 25 weight portions, the Herba Lythri Salicariae of 125 weight portions, the Rhizoma Chuanxiong of 60 weight portions, the Olibanum of 70 weight portions, the Radix Aucklandiae of 70 weight portions, the Radix Glycyrrhizae Preparata of 25 weight portions, the Radix seu Folium Alchorneae trewioidis of 35 weight portions, the Herba Schizonepetae of 15 weight portions, the Radix Dipsaci of 25 weight portions, the Pericarpium Citri Reticulatae Viride of 10 weight portions, the Semen Vaccariae of 32 weight portions, the warfarin of 0.85 weight portion, the taurine of 2.3 weight portions, the alginic acid of 2.3 weight portions.
Further, the pharmaceutical composition of described treatment rheumatic osteopathia, also comprises the Cortex Acanthopancis of the Radix Achyranthis Bidentatae of 15 weight portions, 30 weight portions.
Further, the 20 weight portion Cortexs Eucommiae, the Flos Carthami of 30 weight portions and the Fructus Aurantii of 20 weight portions is also comprised.
(1) get the Rhizoma Et Radix Notopterygii of formula ratio, be crushed to 50 orders, add 10 times amount distilled water, heated and boiled 1.5 hours, cooling centrifugal filtering, filtering residue heated and boiled 1 hour again, centrifugal filtering; It is the ethanol of 80% that filtering residue adds 2 times amount concentration, reflux, extract, 6 hours, centrifugal filtering, 2 times repeatedly, and merge above all filtrate, decompression recycling ethanol, is concentrated into through thin film evaporation the liquid that relative density is the clarification of 0.65, obtains Rhizoma Et Radix Notopterygii extracting solution, stand-by;
(2) Fructus anethi of formula ratio, Radix Gentianae Macrophyllae, Caulis Piperis Kadsurae, Flos abelmoschi manihot, Cortex Cinnamomi, Herba Lythri Salicariae, Rhizoma Chuanxiong, Olibanum, the Radix Aucklandiae, Radix Glycyrrhizae Preparata, Radix seu Folium Alchorneae trewioidis, Herba Schizonepetae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Semen Vaccariae, Radix Achyranthis Bidentatae, Cortex Acanthopancis, the Cortex Eucommiae, Flos Carthami, Fructus Aurantii is got respectively, respectively according to the extracting method of above-mentioned Rhizoma Et Radix Notopterygii, obtain the extracting solution of each raw material, stand-by;
(3) said extracted liquid is put into stainless steel cask, add 52 degree of Chinese liquor, finally add the warfarin of formula ratio, taurine, alginic acid, stir, after ultrasonic disperse and get final product.
Embodiment 6
The pharmaceutical composition for the treatment of rheumatic osteopathia, it is characterized in that: formulated primarily of following ingredients, the Rhizoma Et Radix Notopterygii of 51 weight portions, the Fructus anethi of 47 weight portions, the Radix Gentianae Macrophyllae of 50 weight portions, the Caulis Piperis Kadsurae of 95 weight portions, the Flos abelmoschi manihot of 126 weight portions, the Cortex Cinnamomi of 23 weight portions, the Herba Lythri Salicariae of 120 weight portions, the Rhizoma Chuanxiong of 56 weight portions, the Olibanum of 65 weight portions, the Radix Aucklandiae of 65 weight portions, the Radix Glycyrrhizae Preparata of 20 weight portions, the Radix seu Folium Alchorneae trewioidis of 33 weight portions, the Herba Schizonepetae of 12 weight portions, the Radix Dipsaci of 22 weight portions, the Pericarpium Citri Reticulatae Viride of 8 weight portions, the Semen Vaccariae of 30 weight portions, the warfarin of 0.8 weight portion, the taurine of 1.5 amount parts, the alginic acid of 1.5 weight portions.
(1) get the Rhizoma Et Radix Notopterygii of formula ratio, be crushed to 55 orders, add 10 times amount distilled water, heated and boiled 1.5 hours, cooling centrifugal filtering, filtering residue heated and boiled 1 hour again, centrifugal filtering; It is the ethanol of 70% that filtering residue adds 2 times amount concentration, reflux, extract, 6 hours, centrifugal filtering, 3 times repeatedly, and merge above all filtrate, decompression recycling ethanol, is concentrated into through thin film evaporation the liquid that relative density is the clarification of 0.65, obtains Rhizoma Et Radix Notopterygii extracting solution, stand-by;
(2) Fructus anethi of formula ratio, Radix Gentianae Macrophyllae, Caulis Piperis Kadsurae, Flos abelmoschi manihot, Cortex Cinnamomi, Herba Lythri Salicariae, Rhizoma Chuanxiong, Olibanum, the Radix Aucklandiae, Radix Glycyrrhizae Preparata, Radix seu Folium Alchorneae trewioidis, Herba Schizonepetae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Semen Vaccariae, Radix Achyranthis Bidentatae, Cortex Acanthopancis is got respectively, respectively according to the extracting method of above-mentioned Rhizoma Et Radix Notopterygii, obtain the extracting solution of each raw material, stand-by;
(3) said extracted liquid is put into stainless steel cask, add 52 degree of Chinese liquor, finally add the warfarin of formula ratio, taurine, alginic acid, stir, after ultrasonic disperse and get final product.
Clinical treatment situation:
With in our cure scapulohumeral periarthritis 52 example, man 32 example, female 20 example; More than age 38-61 year.Result: after treating 60, shoulder pain disappears, and movable function is normal, and after 1 year, recidivist is not recovery from illness, and totally 45 examples, account for 86%; Pain disappears, and function does not recover normal completely, or pain, the dysfunction person of being improved for taking a turn for the better, totally 7 examples, account for 14%.
Treatment scapulohumeral periarthritis 56 example, male 24 example, women 32 example; Age 28-68 year; Course of disease 6-60 month; Left shoulder 15 example, right shoulder 39 example, both shoulders 2 example.Criterion of therapeutical effect: recovery from illness: subjective symptoms and clinical sign disappear completely, shoulder arm stretches, shakes without pain; Effective: the activity of acromiobrachial functional training energy has clear improvement, but sometimes still has mild pain; Invalid: subjective symptoms and sign have slight improvement or unchanged, the activity of shoulder arm is still limited.Result: cure 32 examples, effective 11 examples, invalid 13 examples, total effective rate 76.8%, the maximum medication of effective patient 36 doses, minimum 8 doses.
Sampling survey is carried out to added up few patients:
Patient 1: Zhang, man, 44 years old, suffers from scapulohumeral periarthritis 5 years, long-term shoulder pain, shoulder mobility be limited, be afraid of cold, tenderness, muscle spasm and atrophy, after use invention formulation after 1 week, be afraid of cold, tenderness and shoulder pain feel be eased, take invention formulation after 3 weeks, shoulder mobility is limited, muscle spasm and atrophy have also been obtained alleviation, after continuing to take this preparation, pain disappears
Patient 2: Lee, female, 42 years old, suffer from scapulohumeral periarthritis 3 years; shoulder pain, limitation of activity is or/and shoulder amyotrophy, and take invention formulation after 4 weeks, shoulder pain is eased; take invention formulation after 1 month, shoulder pain disappears substantially, and the normal activity of arm, meets the needs of daily life.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (6)
1. treat the pharmaceutical composition of rheumatic osteopathia, it is characterized in that: formulated primarily of following ingredients, the Rhizoma Et Radix Notopterygii of 40-60 weight portion, the Fructus anethi of 40-60 weight portion, the Radix Gentianae Macrophyllae of 40-60 weight portion, the Caulis Piperis Kadsurae of 80-120 weight portion, the Flos abelmoschi manihot of 120-130 weight portion, the Cortex Cinnamomi of 20-30 weight portion, the Herba Lythri Salicariae of 120-130 weight portion, the Rhizoma Chuanxiong of 50-60 weight portion, the Olibanum of 60-70 weight portion, the Radix Aucklandiae of 60-70 weight portion, the Radix Glycyrrhizae Preparata of 20-30 weight portion, the Radix seu Folium Alchorneae trewioidis of 30-40 weight portion, the Herba Schizonepetae of 10-20 weight portion, the Radix Dipsaci of 15-30 weight portion, the Pericarpium Citri Reticulatae Viride of 5-10 weight portion, the Semen Vaccariae of 25-40 weight portion, the warfarin of 0.5-2 weight portion, the taurine of 1-3 weight portion, the alginic acid of 1-2 weight portion.
2. the pharmaceutical composition for the treatment of rheumatic osteopathia according to claim 1, it is characterized in that, formulated primarily of following ingredients, the Rhizoma Et Radix Notopterygii of 48-55 weight portion, the Fructus anethi of 45-50 weight portion, the Radix Gentianae Macrophyllae of 50-52 weight portion, the Caulis Piperis Kadsurae of 90-100 weight portion, the Flos abelmoschi manihot of 125-130 weight portion, the Cortex Cinnamomi of 20-25 weight portion, the Herba Lythri Salicariae of 120-125 weight portion, the Rhizoma Chuanxiong of 55-60 weight portion, the Olibanum of 60-70 weight portion, the Radix Aucklandiae of 65-70 weight portion, the Radix Glycyrrhizae Preparata of 20-25 weight portion, the Radix seu Folium Alchorneae trewioidis of 30-35 weight portion, the Herba Schizonepetae of 10-15 weight portion, the Radix Dipsaci of 20-25 weight portion, the Pericarpium Citri Reticulatae Viride of 5-10 weight portion, the Semen Vaccariae of 30-35 weight portion, the warfarin of 0.5-1 weight portion, 1.5-2 the taurine of weight portion, 1.5-1.8 the alginic acid of weight portion.
3. the pharmaceutical composition for the treatment of rheumatic osteopathia according to claim 1, is characterized in that: the Cortex Acanthopancis also comprising the Radix Achyranthis Bidentatae of 10-15 weight portion, 20-30 weight portion.
4. the pharmaceutical composition of the treatment rheumatic osteopathia according to claim 1 or 3 any one, is characterized in that: also comprise the 20-25 weight portion Cortex Eucommiae, the Flos Carthami of 30-45 weight portion and the Fructus Aurantii of 20-40 weight portion.
5. the pharmaceutical composition for the treatment of rheumatic osteopathia according to claim 1, it is characterized in that: formulated primarily of following ingredients, the Rhizoma Et Radix Notopterygii of 51 weight portions, the Fructus anethi of 47 weight portions, the Radix Gentianae Macrophyllae of 50 weight portions, the Caulis Piperis Kadsurae of 95 weight portions, the Flos abelmoschi manihot of 126 weight portions, the Cortex Cinnamomi of 23 weight portions, the Herba Lythri Salicariae of 120 weight portions, the Rhizoma Chuanxiong of 56 weight portions, the Olibanum of 65 weight portions, the Radix Aucklandiae of 65 weight portions, the Radix Glycyrrhizae Preparata of 20 weight portions, the Radix seu Folium Alchorneae trewioidis of 33 weight portions, the Herba Schizonepetae of 12 weight portions, the Radix Dipsaci of 22 weight portions, the Pericarpium Citri Reticulatae Viride of 8 weight portions, the Semen Vaccariae of 30 weight portions, the warfarin of 0.8 weight portion, the taurine of 1.5 weight portions, the alginic acid of 1.5 weight portions.
6. prepare a method for the pharmaceutical composition of the treatment rheumatic osteopathia as described in claim 1-6, it is characterized in that:
(1) get the Rhizoma Et Radix Notopterygii of formula ratio, be crushed to 50 ~ 60 orders, add 10 times amount distilled water, heated and boiled 1.5 ~ 2 hours, cooling centrifugal filtering, filtering residue heated and boiled 0.5 ~ 1 hour again, centrifugal filtering; It is the ethanol of 65 ~ 80% that filtering residue adds 2 times amount concentration, reflux, extract, 3 ~ 6 hours, centrifugal filtering, 2 ~ 3 times repeatedly, merge above all filtrate, decompression recycling ethanol, be concentrated into through thin film evaporation the liquid that relative density is the clarification of 0.6-0.7, obtain Rhizoma Et Radix Notopterygii extracting solution, stand-by;
(2) Fructus anethi of formula ratio, Radix Gentianae Macrophyllae, Caulis Piperis Kadsurae, Flos abelmoschi manihot, Cortex Cinnamomi, Herba Lythri Salicariae, Rhizoma Chuanxiong, Olibanum, the Radix Aucklandiae, Radix Glycyrrhizae Preparata, Radix seu Folium Alchorneae trewioidis, Herba Schizonepetae, Radix Dipsaci, Pericarpium Citri Reticulatae Viride, Semen Vaccariae is got respectively respectively according to the extracting method of above-mentioned Rhizoma Et Radix Notopterygii, obtain the extracting solution of each raw material, stand-by;
(3) said extracted liquid is put into stainless steel cask, add 52 degree of Chinese liquor, finally add the warfarin of formula ratio, taurine, alginic acid, stir, after ultrasonic disperse and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510874655.6A CN105311210A (en) | 2015-12-02 | 2015-12-02 | Pharmaceutical composition for treating rheumatoid bone diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510874655.6A CN105311210A (en) | 2015-12-02 | 2015-12-02 | Pharmaceutical composition for treating rheumatoid bone diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105311210A true CN105311210A (en) | 2016-02-10 |
Family
ID=55240167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510874655.6A Pending CN105311210A (en) | 2015-12-02 | 2015-12-02 | Pharmaceutical composition for treating rheumatoid bone diseases |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105311210A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105920570A (en) * | 2016-07-04 | 2016-09-07 | 李布仁贺喜格 | A kind of quick-acting externally applied traditional Chinese medicine for treating rheumatic bone disease and its preparation method |
| CN106390131A (en) * | 2016-11-30 | 2017-02-15 | 郑州仁宏医药科技有限公司 | Western medicine composition for treating rheumatic bone disease |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103385930A (en) * | 2012-05-07 | 2013-11-13 | 李建芳 | Quick-acting rheumatism powder |
| CN104027764A (en) * | 2014-06-11 | 2014-09-10 | 张元正 | Medicine for treating rheumatoid bone diseases |
| CN104127571A (en) * | 2014-07-03 | 2014-11-05 | 汪茂林 | Medicinal liquor for treating rheumatoid arthritis |
-
2015
- 2015-12-02 CN CN201510874655.6A patent/CN105311210A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103385930A (en) * | 2012-05-07 | 2013-11-13 | 李建芳 | Quick-acting rheumatism powder |
| CN104027764A (en) * | 2014-06-11 | 2014-09-10 | 张元正 | Medicine for treating rheumatoid bone diseases |
| CN104127571A (en) * | 2014-07-03 | 2014-11-05 | 汪茂林 | Medicinal liquor for treating rheumatoid arthritis |
Non-Patent Citations (2)
| Title |
|---|
| 朱南平等: "《中国常用药品集》", 31 January 2009, 世界图书出版公司 * |
| 陆荣森: "《中医健康指南》", 31 July 2014, 上海科学技术文献出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105920570A (en) * | 2016-07-04 | 2016-09-07 | 李布仁贺喜格 | A kind of quick-acting externally applied traditional Chinese medicine for treating rheumatic bone disease and its preparation method |
| CN106390131A (en) * | 2016-11-30 | 2017-02-15 | 郑州仁宏医药科技有限公司 | Western medicine composition for treating rheumatic bone disease |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102793883B (en) | Plaster for treating intervertebral disc protrusion and cervical spondylosis | |
| CN102512630B (en) | Traditional Chinese medicine composition for treating gallbladder calculus | |
| CN104815295A (en) | Traditional Chinese medicine preparation for treating cervical spondylosis | |
| CN102626505A (en) | Massaging paste based on Chinese medicinal herbs and preparation method thereof | |
| CN104815318A (en) | Traditional Chinese medicine preparation for treating gout | |
| CN105311210A (en) | Pharmaceutical composition for treating rheumatoid bone diseases | |
| CN105709074A (en) | Medicine for treating rheumatic arthritis and hyperostosis and preparation method | |
| CN105343442A (en) | External medicament for treating lubar intervertebral disc protrusion and preparation method thereof | |
| CN103735647A (en) | Medicated wine for treating chronic infectious arthritis | |
| CN103977367A (en) | Traditional Chinese medicament for treating qi-stagnation blood-aggregation type bedsore and preparation method thereof | |
| CN105687444A (en) | Traditional Chinese medicine composition for treating rheumatism and preparation method and application thereof | |
| CN104173932A (en) | Traditional Chinese medicine composition for treating cervical spondylosis | |
| CN101637535B (en) | Medicine for treating bone hyperplasia and preparation method thereof | |
| CN103285108B (en) | Chinese medicinal composition treating lumbago | |
| CN102028810B (en) | Traditional Chinese medicine for treating lumbar intervertebral disc protrusion | |
| CN102397422A (en) | Chinese herbal medicine preparation for treating ischemic necrosis of femoral head | |
| CN101658648B (en) | Medicament for treating cervical erosion | |
| CN100482259C (en) | Chinese medicine for treating cervical spondylosis | |
| CN106139042A (en) | A kind of new medicine composition treating cervical spondylopathy and preparation method thereof | |
| CN104840814A (en) | Traditional Chinese medicine combination for treating senile femoral head necrosis | |
| CN104971313A (en) | Ancient prescription big plaster for treating various rheumatism bone diseases and traumatic injury | |
| CN105770655A (en) | Traditional Chinese medicine composition for treating scroti eczema | |
| CN105194411A (en) | Formula of traditional Chinese medicine for treating scapulobumeral periarthritis | |
| CN100435821C (en) | Medicine for treating rheumatoid disease | |
| CN121910836A (en) | Traditional Chinese medicine for treating neuralgia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 261599 No. 77 Town Street, Shandong, Gaomi City Applicant after: Sui Yanlei Address before: 261599 No. 77 Town Street, Weifang, Shandong Applicant before: Sui Yanlei |
|
| COR | Change of bibliographic data | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160210 |