CN102488812B - Bone fracture oral medicine, preparation method thereof, and application method thereof - Google Patents
Bone fracture oral medicine, preparation method thereof, and application method thereof Download PDFInfo
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- CN102488812B CN102488812B CN201110440628.XA CN201110440628A CN102488812B CN 102488812 B CN102488812 B CN 102488812B CN 201110440628 A CN201110440628 A CN 201110440628A CN 102488812 B CN102488812 B CN 102488812B
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Abstract
The invention relates to a formula of an oral medicine used for treating bone fracture, a preparation method thereof, and an application method thereof. The medicine is composed of medicine materials of, by weight: 10-15 parts of ligusticum, 10-15 parts of yanhusuo tuber, 10-15 parts of white peony root, 10-15 parts of safflower, 10-15 parts of angelica archang lica, 10-15 parts of dipsacus asper, 10-15 parts of ground beetle, 10-15 parts of fortune's drynaria rhizome, 10-15 parts of native copper, 10-15 parts of dragon's blood, 10-15 parts of suberect spatholobus stem, 10-15 parts of eucommia, 10-15 parts of prepared rehmannia rhizome, 10-15 parts of licorice root, and 10-15 parts of radix notoginseng powder. The medicine materials can be prepared into decoctions or pills. According to different phases of the pathogenetic condition of a bone fracture patient, such as an early-stage, a middle-stage or a later-stage, treatments are carried out by using different preparation forms. With the medicine provided by the invention, bone fracture can be rapidly cured with an effective rate of 100%. The medicine application is flexible, and a targeting effect is good. The medicine can be effectively delivered to a bone fracture position, such that the effect of the medicine can be better developed. The oral medicine causes no toxic or side effect.
Description
Technical field
The present invention relates to a kind of medicine and preparation and application thereof, refer in particular to a kind of formula and production method and using method for the treatment of the Chinese medicine for oral administration of fracture.
Background technology
Bone injury is the commonly encountered diseases of serious harm health, frequently-occurring disease, and fracture is disease the most general in bone disease, the method for the treatment of fracture at present, doctor trained in Western medicine generally adopts operation or planter cast binder to fix and is aided with necessary interior medicine for external use, and patient suffering is large, and healing is slow.The Drug therapys such as the multiplex Cortex torricelliae tiliifoliae of Traditional Chinese Medicine, bone-connecting pill, medicine time is long, takes inconvenience, and it is fried that effective ingredient is difficult for, and dispenser is dumb, and union of fracture is slow, therefore curative effect is undesirable.The oral drugs of other treatment fracture, by literature search, that applies for a patent only has two kinds at present, if Chinese Patent Application No. is 98124816.0 to disclose a kind for the treatment of and fall endo-medicine of fracture and preparation method thereof, it is comprised of the crude drug of lower routine weight portion: Rhizoma Drynariae 10-20g, Myrrha 10-20g; Olibanum 10-20g, Sanguis Draxonis 10-20g, Borax 10-20g, Radix Angelicae Sinensis 10-20g; Radix Et Rhizoma Rhei 10-20, Pyritum 10-20g, Eupolyphaga Seu Steleophaga 10-20g, its dosage form powder.Another Chinese Patent Application No. is 200610012839.2 to disclose a kind of oral drugs of set a broken bone, it is comprised of the crude drug of following weight portion: Cornu Cervi Pantotrichum 3-4, Solenognathus 3-4, Potiria pectinifera (Mukller et Tro Sehel) 4-5, Testis et penis callorhini 4-5, Moschus 2-3, Rhizoma Drynariae 5-6, Cortex Eucommiae 6-7, Radix clematidis ranunculoidis 3-4, Radix seu folium Gaultheriae intermediae 4-5, Radix Notoginseng 6-7, stir-baked SQUAMA MANITIS 3-4, Sanguis Draxonis 3-4, Lycopodium casuarinoides Spring 6-7, Olibanum (processed) 2-3, Myrrha (processed) 3-4, Pyritum (calcined) 5-6, Radix Achyranthis Bidentatae 3-4, Stigma Croci 5-6, female ground beetle 5-6, Radix Dipsaci 3-4, Radix Paeoniae Alba 3-4, Caulis Bauhihiae Championii 3-4, Radix Lamiophlomidis Rotatae 3-4, Radix Glycyrrhizae 1-2.Its dosage form is powder or capsule.
Above-mentioned patent, as document 1, forms from prescription, lays particular emphasis on the congestion and swelling pain that fracture causes in early days, take blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain as main.Therapeutic effect to fracture middle and late stage is not good.The party makes powder, is not easy to take and dispenser flexibly, and pharmaceutical properties is unstable, and easily the moisture absorption is rotten, and dosage is larger, is difficult to grasp; In prescription, the medical material such as Olibanum, Radix Et Rhizoma Rhei, Radix Angelicae Sinensis is containing the more powder of should not making of volatile ingredient, otherwise effective ingredient is difficult for stripping, and curative effect of medication is difficult to embody.The medical materials such as the Cornu Cervi Pantotrichum in document 2 drug prescriptions, Solenognathus, Hippocampus, Potiria pectinifera (Mukller et Tro Sehel), Moschus, stir-baked SQUAMA MANITIS are not only expensive, and patient burden is too large, and scarcity of resources, is unfavorable for extensively promoting the use of, and cannot be used by vast general patient.In the party, some drugs, if the medicines such as Lysimachia trientaloides Hemsl., nine dragons, female ground beetle, Radix clematidis ranunculoidis are Chinese herbal medicine among the people, has both seldom arrived, and excludes again Chinese Pharmacopoeia, its quality standard is uncontrollable, resource-constrained, and price is high, in suitability for industrialized production, difficult quality is controlled, and is also unfavorable for wide popularization and application.
Motherland's medical science is thought: fracture patient is many because of the brute force torsion that suffers to occur suddenly, tractive, the violence such as shock makes local venation generation coagulation of QI-blood with sudden force, and hematoma formation, causes damaged part swelling pain and dysfunction.Conditions of patients is in different times, and its pathological characters has very large difference, and for medicine, even if same prescription is made different dosage forms, its action effect has very big-difference.And above-mentioned prior art is all that a kind of prescription is made to powder or capsule, oral administration, its dosage form is single, cannot there is the next timing of rear different times of living in, quantitatively dispenser according to fracture in doctor in therapeutic process, can not adopt different pharmaceutical dosage form dispensers according to change of illness state, can only adjust administration time length according to patient's the state of an illness at most, so can said medicine reach optimum effective concentration in concrete medication process, optimum therapeuticing effect is unknown.
Therefore, treatment of the prior art fracture medicine exists specific aim not strong, and onset is slow, and healing time is long, and expensive, raw material sources such as are restricted at the deficiency, necessary this is improved.
Summary of the invention
The object of the invention is to the deficiency existing for existing treatment fracture medicine speed, a kind of fracture oral medicine is provided; It can provide drug form with strong points according to fracture patient state of an illness different phase of living in, have rapid-action, the advantage such as healing time is short, and raw material sources are extensive.
Another object of the present invention is to provide a kind of production method of the oral medicine of fracturing; It can make produced medicine reach above-mentioned effect.
A further object of the invention provides a kind of using method of the oral medicine of fracturing; It can make said medicine reach best result of use.
Technical scheme of the present invention is:
An oral medicine, is characterized in that: it is made by the crude drug of following weight portion:
Radix Angelicae Sinensis 10-15 part, Rhizoma Corydalis 10-15 part, Radix Paeoniae Alba 10-15 part, Flos Carthami 10-15 part, Radix Angelicae Dahuricae 10-15 part, Radix Dipsaci 10-15 part, Eupolyphaga Seu Steleophaga 10-15 part, Rhizoma Drynariae 10-15 part, Pyritum 10-15 part, Sanguis Draxonis 10-15 part, Caulis Spatholobi 10-15 part, Cortex Eucommiae 10-15 part, Radix Rehmanniae Preparata 10-15 part, Radix Glycyrrhizae 10-15 part, Radix Notoginseng 10-15 part (powder).
As to further improvement of the present invention, the weight portion of described crude drug is:
Radix Angelicae Sinensis 12g, Rhizoma Corydalis 12 g, Radix Paeoniae Alba 10g, Flos Carthami 10g, Radix Angelicae Dahuricae 12g, Radix Dipsaci 12g, ground beetle 12g, Rhizoma Drynariae 12g, Pyritum 10g, Sanguis Draxonis 10g, Caulis Spatholobi 12g, Cortex Eucommiae 12g, Radix Rehmanniae Preparata 12g, Radix Glycyrrhizae 6g, Radix Notoginseng 10g(powder) conduct is to further improvement of the present invention, and the fracture oral medicine that described crude drug is made can be decoction or pill.
As to further improvement of the present invention, described crude drug is made fracture oral medicine decoction, two kinds of different dosage forms of fracture oral medicine pill, and described fracture oral medicine is the composition of medicine being combined by fracture oral medicine decoction, fracture oral medicine pill.
A production method for above-mentioned fracture oral medicine, the production method of fracture oral medicine decoction is except Radix Notoginseng powder, each raw material of all the other ingredients to be decocted respectively to twice according to a conventional method, mixes decoction liquor twice, adds Radix Notoginseng powder mix homogeneously, makes decoction.
A kind of production method of above-mentioned fracture oral medicine pill is according to a conventional method Sanguis Draxonis, the Radix Angelicae Dahuricae to be processed into fine powder, Flos Carthami in crude drug, Radix Angelicae Sinensis are extracted respectively to volatile oil, extract medicinal residues and all the other raw material mixing and water adding decocting and concentrating paste making agents after volatile oil, to adding in unguentum, pulverize standby Sanguis Draxonis, the Radix Angelicae Dahuricae, Radix Notoginseng fine powder mix homogeneously, the volatile oil that adds said extracted, mix, practicing honey is ball, makes pill.
A kind of application method of above-mentioned fracture oral medicine decoction is oral according to a conventional method, each 100 ∽ 150ml, every day 2 times.
A kind of application method of above-mentioned fracture oral medicine pill is oral according to a conventional method, each 9g, every day 2 times.
A kind of using method of above-mentioned fracture oral medicine, fracture oral medicine decoction is applied to the fracture initial stage, the described fracture initial stage refers to initial fracture to beginning to take shape callus period, be every day 2 times the medicine time of described fracture oral medicine decoction, treatment time is 3-7 days, described fracture oral medicine pill is applied in fracture, later stage, described fracture refers to and begin to take shape callus to all forming callus period mid-term, the anaphase of bone fracture refers to that whole formation callus are to functional rehabilitation period, described fracture oral medicine pill is every day 2 times medicine time, treatment time is 7-30 days.
beneficial effect of the present invention is
1, the raw material sources of medicine of the present invention are wide, and price is lower, easily realize standardized production, possess the condition of wide popularization and application.Ten Chinese medicine of the five flavours in its raw material all come from the kind that " Chinese Pharmacopoeia " records, and medicine source is wide, and quality standard is controlled.
2, the present invention is according to the Therapeutic Principle of " injury of configuration resulting in swelling, impairment of QI resulting in pain " and " stagnation of QI and blood may bring about pain ", and prescription compatibility be take blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, reunion of bone as main.The present invention selects Radix Angelicae Sinensis, Flos Carthami blood circulation promoting and blood stasis dispelling, pain relieving; Rhizoma Corydalis, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae are regulated the flow of vital energy, reducing swelling and alleviating pain.Be equipped with Eupolyphaga Seu Steleophaga, Rhizoma Drynariae, Pyritum dissipating blood stasis, invigorate blood circulation, the synthetism of curing the wound.Sanguis Draxonis, pseudo-ginseng blood-circulation-invigovating analgesic therapy, removing stasis to stop bleeding.Caulis Spatholobi promoting blood circulation and hemostasis, soothing the channels and quicking the network vessels.Radix Dipsaci, the Cortex Eucommiae, Radix Rehmanniae Preparata liver and kidney tonifying, strong muscle are built bone.Radix Glycyrrhizae invigorating the spleen and replenishing QI, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.All medicine compatibilities bring out the best in each other, and reach the merit of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, reunion of bone.
3, production method of the present invention, technique and simple to operate, to production equipment without specific (special) requirements.
4, two kinds of dosage forms of the present invention both can be used alone, and also can combine simultaneously and use treatment by stages fracture illness, and concrete service condition will be according to patient's the flexible dispenser of fracture pathological characters.As fracture oral medicine decoction is applied to the fracture treatment in early stage, be applied to the to fracture treatment of intermediary and later stages of fracture oral medicine pill.
5, two kinds of drug forms have respectively following characteristics: decoction proves effective rapidly, can add and subtract with disease, dispenser is flexible, and the pathological characters at fracture initial stage is that fracture site congestion is serious, blood flow hinders larger, damage surface is wider, and pain is serious etc., in this stage, adopts decoction treatment, medicine can reach rapidly lesions position, improve stagnation of QI-blood, congestion swelling phenomenon, accelerate congestion position blood flow, alleviate rapidly patient's misery.
Pill leaches, discharges drug slow, can extend drug effect, reduces toxicity, zest, reduces untoward reaction; Be applicable to chronic disease treatment or QI and blood regulating after being ill; Make pill, be administered to the fracture intermediary and later stages, the pathological characters of fracture intermediary and later stages is that congestion swelling phenomenon improves substantially, and therapeutic purposes are to promote union of fracture, recover fracture function.And this stage is a slow and progressive process, therefore, we make pill and are administered to the fracture intermediary and later stages, get final product on the one hand QI and blood regulating, extend drug effect, keep fracture site drug level, recover rapidly fracture function, also can reduce drug toxicity, zest on the other hand, reduce untoward reaction and occur.
Medicine of the present invention proves effective soon, and targeting is strong, can effectively reach fracture site, bring into play better the due effect of medicine, greatly reduce the generation of adverse effect, prevent the waste of drug resource, shorten the time of union of fracture, greatly alleviated patient's misery and financial burden.
The specific embodiment
single medicine embodiment
embodiment 1
An oral medicine, its prescription is following component and weight (part) ratio:
Radix Angelicae Sinensis 12g, Rhizoma Corydalis 12 g, Radix Paeoniae Alba 10g, Flos Carthami 10g, Radix Angelicae Dahuricae 12g, Radix Dipsaci 12g, Eupolyphaga Seu Steleophaga 12g, Rhizoma Drynariae 12g, Pyritum 10g, Sanguis Draxonis 10g, Caulis Spatholobi 12g, Cortex Eucommiae 12g, Radix Rehmanniae Preparata 12g, Radix Glycyrrhizae 6g, Radix Notoginseng 10g(powder) fracture oral medicine is to take above-mentioned prescription as basic fracture oral medicine decoction, and the production method of fracture oral medicine decoction is except Radix Notoginseng powder, each raw material of all the other ingredients to be decocted respectively to twice according to a conventional method, mixes decoction liquor twice, add Radix Notoginseng powder mix homogeneously, make decoction.
The application method of fracture oral medicine decoction is oral according to a conventional method, each 100 ∽ 150ml, every day 2 times.
embodiment 2
An oral medicine, its prescription is following component and weight (part) ratio:
Radix Angelicae Sinensis 15g, Rhizoma Corydalis 12g, Radix Paeoniae Alba 12g, Flos Carthami 12g, Radix Angelicae Dahuricae 12g, Radix Dipsaci 10g, Eupolyphaga Seu Steleophaga 10g, Rhizoma Drynariae 12g, Pyritum 10g, Sanguis Draxonis 12g, Caulis Spatholobi 10g, Cortex Eucommiae 10g, Radix Rehmanniae Preparata 10g, Radix Glycyrrhizae 6g, Radix Notoginseng 10g(powder) its production method and using method be with embodiment 1.
embodiment 3
An oral medicine, its prescription is following component and weight (part) ratio:
Radix Angelicae Sinensis 15g, Rhizoma Corydalis 15g, Radix Paeoniae Alba 10g, Flos Carthami 12g, Radix Angelicae Dahuricae 12g, Radix Dipsaci 12g, Eupolyphaga Seu Steleophaga 10g, Rhizoma Drynariae 10g, Pyritum 10g, Sanguis Draxonis 10g, Caulis Spatholobi 10g, Cortex Eucommiae 10g, Radix Rehmanniae Preparata 10g, Radix Glycyrrhizae 6g, Radix Notoginseng 12g(powder) its production method and using method be with embodiment 1.
embodiment 4
An oral medicine, its prescription is following component and weight (part) ratio:
Radix Angelicae Sinensis 10g, Rhizoma Corydalis 12g, Radix Paeoniae Alba 10g, Flos Carthami 12g, Radix Angelicae Dahuricae 12g, Radix Dipsaci 12g, Eupolyphaga Seu Steleophaga 10g, Rhizoma Drynariae 10g, Pyritum 10g, Sanguis Draxonis 10g, Caulis Spatholobi 12g, Cortex Eucommiae 12g, Radix Rehmanniae Preparata 10g, Radix Glycyrrhizae 6g, Radix Notoginseng 10g(powder) its production method and using method be with embodiment 1.
clinical model case:
1,the fracture oral medicine decoction that embodiment 1 makes is used for the treatment of 1. Zhao, female, 28 years old, because of by bike accidentally traumatic injury cause right outside fracture of ankle, through outer fixing, after oral this decoction treatment, 1 day pain only, rehabilitation after 7 days; 2. Yuan, man, 52 years old, because of traumatic injury accidentally by motorcycle, cause right radius far-end fracture, sharp ache, under X-ray machine, positive double counterpoint is fixed with plintlet, takes the pain relieving at that time of this medicine, rehabilitation after 10 days.
2, the fracture oral medicine decoction that embodiment 2 makes is used for the treatment of Hu, man, and 73 years old, go downstairs and accidentally fall down, cause the dry fracture of fl, very painful, through reset plintlet, fix, take the pain relieving at once of this medicine, rehabilitation after 30 days.
3, the fracture oral medicine decoction that embodiment 3 makes is used for the treatment of Tan, female, and 43 years old, because accidentally getting into an accident, cause left fracture of radius, pain unbearably, is fixed through reset plintlet, takes the pain relieving immediately of this medicine, rehabilitation after 20 days.
4, the fracture oral medicine decoction that embodiment 4 makes is used for the treatment of Cai, female, and 9 years old, because accidentally falling down impaired left ankle pain, deformity, the limitation of activity of causing.After Nie Zuo ankle x line sheet, be diagnosed as " left inside fracture of ankle ".Give manual reduction, plintlet is fixing outward, takes the pain relieving at that time of this medicine, rehabilitation after 10 days.
embodiment 5
An oral medicine, its prescription is following component and weight (part) ratio:
Radix Angelicae Sinensis 12g, Rhizoma Corydalis 12 g, Radix Paeoniae Alba 10g, Flos Carthami 10g, Radix Angelicae Dahuricae 12g, Radix Dipsaci 12g, Eupolyphaga Seu Steleophaga 12g, Rhizoma Drynariae 12g, Pyritum 10g, Sanguis Draxonis 10g, Caulis Spatholobi 12g, Cortex Eucommiae 12g, Radix Rehmanniae Preparata 12g, Radix Glycyrrhizae 6g, Radix Notoginseng 10g(powder) fracture oral medicine is to take above-mentioned prescription as basic fracture oral medicine pill, the production method of fracture oral medicine pill is according to a conventional method by Sanguis Draxonis, the Radix Angelicae Dahuricae is processed into fine powder, by the Flos Carthami in crude drug, Radix Angelicae Sinensis extracts respectively volatile oil, extract medicinal residues and all the other raw material mixing and water adding decocting and concentrating paste making agents after volatile oil, to adding in unguentum, pulverize standby Sanguis Draxonis, the Radix Angelicae Dahuricae, Radix Notoginseng fine powder mix homogeneously, the volatile oil that adds said extracted, mix, practicing honey is ball, make pill.
The application method of fracture oral medicine pill is oral according to a conventional method, each 9g, every day 2 times.
embodiment 6
An oral medicine, its prescription is following component and weight (part) ratio:
Radix Angelicae Sinensis 15g, Rhizoma Corydalis 12g, Radix Paeoniae Alba 12g, Flos Carthami 12g, Radix Angelicae Dahuricae 12g, Radix Dipsaci 10g, Eupolyphaga Seu Steleophaga 10g, Rhizoma Drynariae 12g, Pyritum 10g, Sanguis Draxonis 12g, Caulis Spatholobi 10g, Cortex Eucommiae 10g, Radix Rehmanniae Preparata 10g, Radix Glycyrrhizae 6g, Radix Notoginseng 10g(powder) its production method and using method be with embodiment 5.
embodiment 7
An oral medicine, its prescription is following component and weight (part) ratio:
Radix Angelicae Sinensis 15g, Rhizoma Corydalis 15g, Radix Paeoniae Alba 10g, Flos Carthami 12g, Radix Angelicae Dahuricae 12g, Radix Dipsaci 12g, Eupolyphaga Seu Steleophaga 10g, Rhizoma Drynariae 10g, Pyritum 10g, Sanguis Draxonis 10g, Caulis Spatholobi 10g, Cortex Eucommiae 10g, Radix Rehmanniae Preparata 10g, Radix Glycyrrhizae 6g, Radix Notoginseng 12g(powder) its production method and using method be with embodiment 5.
embodiment 8
An oral medicine, its prescription is following component and weight (part) ratio:
Radix Angelicae Sinensis 10g, Rhizoma Corydalis 12g, Radix Paeoniae Alba 10g, Flos Carthami 12g, Radix Angelicae Dahuricae 12g, Radix Dipsaci 12g, Eupolyphaga Seu Steleophaga 10g, Rhizoma Drynariae 10g, Pyritum 10g, Sanguis Draxonis 10g, Caulis Spatholobi 12g, Cortex Eucommiae 12g, Radix Rehmanniae Preparata 10g, Radix Glycyrrhizae 6g, Radix Notoginseng 10g(powder) its production method and using method be with embodiment 5.
clinical model case:
1,the fracture oral medicine pill that embodiment 5 makes is used for the treatment of the summer, man, 42 years old, because traffic accident causes left tibia and fibula stage casing comminuted fracture, use fracture oral medicine pill, 3 days swollen afterwards disappears, pain only, rehabilitation after 25 days.
2, the fracture oral medicine pill that embodiment 6 makes is used for the treatment of wishes certain, and female 19 years old, because of the foreign object head that accidentally falls, causes skull fracture, through using fracture oral medicine pill, rehabilitation after 15 days.
3, the fracture oral medicine pill that embodiment 7 makes is used for the treatment of Deng, man, and 33 years old, because traffic accident causes two upper limb comminuted fracture, many places soft tissue contusion, through being used fracture oral medicine pill, rehabilitation after 30 days.
4, the fracture oral medicine pill that embodiment 8 makes is used for the treatment of Huang, female, and 39 years old, before one month, because traffic accident causes right forearm fracture, through x line sheet, checked, epimere fracture in right radioulnar, after adopting other drug treatment, pain does not subtract.Through using fracture oral medicine pill treatment of the present invention, after 3 days, pain disappears, patient's rehabilitation after 9 days.
drug regimen treatment embodiment
embodiment 1
An oral medicine, its prescription is following component and weight (part) ratio:
Radix Angelicae Sinensis 12g, Rhizoma Corydalis 12 g, Radix Paeoniae Alba 10g, Flos Carthami 10g, Radix Angelicae Dahuricae 12g, Radix Dipsaci 12g, Eupolyphaga Seu Steleophaga 12g, Rhizoma Drynariae 12g, Pyritum 10g, Sanguis Draxonis 10g, Caulis Spatholobi 12g, Cortex Eucommiae 12g, Radix Rehmanniae Preparata 12g, Radix Glycyrrhizae 6g, Radix Notoginseng 10g(powder) fracture oral medicine is to take fracture oral medicine decoction, the fracture oral medicine pill that above-mentioned crude drug makes as basis.
The production method of fracture oral medicine decoction is except Radix Notoginseng powder, each raw material of all the other ingredients to be decocted respectively to twice according to a conventional method, mixes decoction liquor twice, adds Radix Notoginseng powder mix homogeneously, makes decoction.
The production method of fracture oral medicine pill is according to a conventional method Sanguis Draxonis, the Radix Angelicae Dahuricae to be processed into fine powder, Flos Carthami in crude drug, Radix Angelicae Sinensis are extracted respectively to volatile oil, extract medicinal residues and all the other raw material mixing and water adding decocting and concentrating paste making agents after volatile oil, to adding in unguentum, pulverize standby Sanguis Draxonis, the Radix Angelicae Dahuricae, Radix Notoginseng fine powder mix homogeneously, the volatile oil that adds said extracted, mix, practicing honey is ball, makes pill.
The application method of fracture oral medicine decoction is oral according to a conventional method, each 100 ∽ 150ml, every day 2 times.
The application method of fracture oral medicine pill is oral according to a conventional method, each 1 (9g), every day 2 times.
embodiment 2
An oral medicine, its prescription is following component and weight (part) ratio:
Radix Angelicae Sinensis 15g, Rhizoma Corydalis 12g, Radix Paeoniae Alba 12g, Flos Carthami 12g, Radix Angelicae Dahuricae 12g, Radix Dipsaci 10g, Eupolyphaga Seu Steleophaga 10g, Rhizoma Drynariae 12g, Pyritum 10g, Sanguis Draxonis 12g, Caulis Spatholobi 10g, Cortex Eucommiae 10g, Radix Rehmanniae Preparata 10g, Radix Glycyrrhizae 6g, Radix Notoginseng 10g(powder) its production method and using method be with embodiment 1.
embodiment 3
An oral medicine, its prescription is following component and weight (part) ratio:
Radix Angelicae Sinensis 15g, Rhizoma Corydalis 15g, Radix Paeoniae Alba 10g, Flos Carthami 12g, Radix Angelicae Dahuricae 12g, Radix Dipsaci 12g, Eupolyphaga Seu Steleophaga 10g, Rhizoma Drynariae 10g, Pyritum 10g, Sanguis Draxonis 10g, Caulis Spatholobi 10g, Cortex Eucommiae 10g, Radix Rehmanniae Preparata 10g, Radix Glycyrrhizae 6g, Radix Notoginseng 12g(powder) its production method and using method be with embodiment 1.
embodiment 4
An oral medicine, its prescription is following component and weight (part) ratio:
Radix Angelicae Sinensis 10g, Rhizoma Corydalis 12g, Radix Paeoniae Alba 10g, Flos Carthami 12g, Radix Angelicae Dahuricae 12g, Radix Dipsaci 12g, Eupolyphaga Seu Steleophaga 10g, Rhizoma Drynariae 10g, Pyritum 10g, Sanguis Draxonis 10g, Caulis Spatholobi 12g, Cortex Eucommiae 12g, Radix Rehmanniae Preparata 10g, Radix Glycyrrhizae 6g, Radix Notoginseng 10g(powder) its production method and using method be with embodiment 1.
clinical model case:
1, the fracture oral medicine that embodiment 1 makes is used for the treatment of Yao, man, and 47 years old, because of traumatic injury by motorcycle, cause right foot swelling, pain, difficult on foot, through x sheet, check: right comminuted calcaneal fracture, fixing through external splint wrapping.Bring into use the present invention's oral medicine decoction of fracturing, oral, each 100 ∽ 150ml, every day 2 times.Use after one day, pain only, swells and disappears for three days afterwards.Within the 4th day, use fracture oral medicine pill instead, oral, each 9g, every day 2 times.Treat rehabilitation after 10 days.
2, the fracture oral medicine that embodiment 2 makes is used for the treatment of Zhu, female, and 45 years old, ride the careless traumatic injury of electric motor car, cause right oar, open fracture of distal end of ulna, hurt like hell.Through using the present invention's oral medicine decoction treatment 1 day of fracturing, pain only.Within three days, swell and disappear afterwards.Within the 5th day, use bone fracture oral medicine pill instead, within 10 days, by x sheet, check, find that union of fracture is good, continue to use the after treatment of fracture oral medicine pill, within 3 days, cure afterwards.
3, the fracture oral medicine that embodiment 3 makes is used for the treatment of Shao, man, and 33 years old, in building site, careless Cong San threw in building, caused right tibia and right fracture of radius.Use fracture oral medicine decoction treatment of the present invention 7 days, three days afterwards bitterly only.The 7th day swollen disappearing.By x photo, find good, the existing a small amount of callus formation of fracture, use fracture oral medicine pill continual cure instead, within 20 days, cure afterwards.
4, the fracture oral medicine that embodiment 4 makes is used for the treatment of money, man, and 59 years old, because accidentally being wounded and cause left chest pain by automobile, limitation of activity, is diagnosed as chest the 4th, 5,6 fractures of rib through the inspection of x sheet, through wrap up fixing after, use fracture oral medicine decoction oral, after 3 days, swell and disappear, bitterly stop.Within the 5th day, x photo is found good, the existing a small amount of callus formation of fracture, within the 6th day, uses the treatment of fracture oral medicine pill instead, and after 10 days, x sheet checks, finds that union of fracture is good, continues to use the after treatment of fracture oral medicine pill, within 5 days, cures afterwards.
in the present invention, all property of medicine tastes and function are as follows:
Radix Angelicae Sinensis: sweet, pungent, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, the effect of menstruction regulating and pain relieving.The chief editor of (" Chinese Pharmacopoeia ") 124Ye， Chinese Pharmacopoeia Commission, Chinese Medicine science and technology publishing house, within 2010, version is one);
Rhizoma Corydalis: acrid, bitter, warm.Return liver, spleen channel.Have invigorate blood circulation, the effect of circulation of qi promoting, pain relieving.(the same 130 pages);
The Radix Paeoniae Alba: bitter, acid, be slightly cold.Return liver, spleen channel.The effect that has nourishing blood for regulating menstruation, pain relieving.(the same 96 pages);
The Radix Angelicae Dahuricae: pungent, warm.Return stomach, large intestine, lung meridian.There is expelling pathogenic wind from the body surface, pain relieving, detumescence and apocenosis, the effect of dampness leukorrhagia stopping.(the same 97 pages);
Flos Carthami: pungent, warm.GUIXIN, Liver Channel.There is promoting blood flow to regulate menstruation, the effect of eliminating stasis to stop pain.(the same 141 pages);
Radix Dipsaci: bitter, pungent, tepor.Return liver, kidney channel.The effect that has invigorating the liver and kidney, bone and muscle strengthening, continuous injured.(the same 309 pages);
Eupolyphaga Seu Steleophaga: salty, cold, slightly poisonous.Return Liver Channel.There is removing blood stasis by silt, the effect of reunion of fractured tendons and bones.(the same 18 pages);
Rhizoma Drynariae: bitter, warm.Return liver, kidney channel.The pain relieving of curing the wound, the effect of the kidney invigorating bone strengthening.(the same 239 pages);
Pyritum: pungent, flat.Return Liver Channel.There is eliminating stasis to stop pain, the effect of reunion of fractured tendons and bones.(the same 132 pages);
Sanguis Draxonis: sweet, salty, flat.GUIXIN, Liver Channel.The analgesic therapy of invigorating blood circulation, removing stasis to stop bleeding, the effect of life sore.(the same 133 pages);
Caulis Spatholobi: bitter, sweet, warm.Return liver, kidney channel.There is blood circulation promoting and enriching, the effect of soothing the channels and quicking the network vessels.(the same 180 pages);
The Cortex Eucommiae: sweet, warm.Return liver, kidney channel.The effect that has invigorating the liver and kidney, bone and muscle strengthening.(the same 154 pages);
Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.The YIN nourishing of enriching blood, beneficial essence is filled out the effect of marrow.(the same 116 pages);
Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.There is invigorating the spleen and replenishing QI, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription.(the same 80 pages);
Radix Notoginseng: sweet, micro-hardship, temperature.Return liver, stomach warp.There is dissipating blood stasis hemostasis, the effect of subduing swelling and relieving pain.(the same 11 pages).
beneficial effect of the present invention is:
1, the raw material sources of medicine of the present invention are wide, and price is lower, easily realize standardized production, possess the condition of wide popularization and application.Ten Chinese medicine of the five flavours in its raw material all come from the kind that " Chinese Pharmacopoeia " records, and medicine source is wide, and quality standard is controlled.
2, the present invention is according to the Therapeutic Principle of " injury of configuration resulting in swelling, impairment of QI resulting in pain " and " stagnation of QI and blood may bring about pain ", and prescription compatibility be take blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, reunion of bone as main.The present invention selects Radix Angelicae Sinensis, Flos Carthami blood circulation promoting and blood stasis dispelling, pain relieving; Rhizoma Corydalis, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae are regulated the flow of vital energy, reducing swelling and alleviating pain.Be equipped with Eupolyphaga Seu Steleophaga, Rhizoma Drynariae, Pyritum dissipating blood stasis, invigorate blood circulation, the synthetism of curing the wound.Sanguis Draxonis, pseudo-ginseng blood-circulation-invigovating analgesic therapy, removing stasis to stop bleeding.Caulis Spatholobi promoting blood circulation and hemostasis, soothing the channels and quicking the network vessels.Radix Dipsaci, the Cortex Eucommiae, Radix Rehmanniae Preparata liver and kidney tonifying, strong muscle are built bone.Radix Glycyrrhizae invigorating the spleen and replenishing QI, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.All medicine compatibilities bring out the best in each other, and reach the merit of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, reunion of bone.
3, production method of the present invention, technique and simple to operate, to production equipment without specific (special) requirements.
4, two kinds of dosage forms of the present invention both can be used alone, and also can combine simultaneously and use treatment by stages fracture illness, and concrete service condition will be according to patient's the flexible dispenser of fracture pathological characters.As fracture oral medicine decoction is applied to the fracture treatment in early stage, be applied to the to fracture treatment of intermediary and later stages of fracture oral medicine pill.
5, two kinds of drug forms have respectively following characteristics: decoction proves effective rapidly, can add and subtract with disease, dispenser is flexible, and the pathological characters at fracture initial stage is that fracture site congestion is serious, blood flow hinders larger, damage surface is wider, and pain is serious etc., in this stage, adopts decoction treatment, medicine can reach rapidly lesions position, improve stagnation of QI-blood, congestion swelling phenomenon, accelerate congestion position blood flow, alleviate rapidly patient's misery.
Pill leaches, discharges drug slow, can extend drug effect, reduces toxicity, zest, reduces untoward reaction; Be applicable to chronic disease treatment or QI and blood regulating after being ill; Make pill, be administered to the fracture intermediary and later stages, the pathological characters of fracture intermediary and later stages is that congestion swelling phenomenon improves substantially, and therapeutic purposes are to promote union of fracture, recover fracture function.And this stage is a slow and progressive process, therefore, we make pill and are administered to the fracture intermediary and later stages, get final product on the one hand QI and blood regulating, extend drug effect, keep fracture site drug level, recover rapidly fracture function, also can reduce drug toxicity, zest on the other hand, reduce untoward reaction and occur.
Medicine of the present invention proves effective soon, and targeting is strong, can effectively reach fracture site, bring into play better the due effect of medicine, greatly reduce the generation of adverse effect, prevent the waste of drug resource, shorten the time of union of fracture, greatly alleviated patient's misery and financial burden.
Claims (4)
1. a treatment fracture oral medicine, is characterized in that: the crude drug proportioning by following weight portion is made:
Radix Angelicae Sinensis 10-15 part, Rhizoma Corydalis 10-15 part, Radix Paeoniae Alba 10-15 part, Flos Carthami 10-15 part, Radix Angelicae Dahuricae 10-15 part, Radix Dipsaci 10-15 part, Eupolyphaga Seu Steleophaga 10-15 part, Rhizoma Drynariae 10-15 part, Pyritum 10-15 part, Sanguis Draxonis 10-15 part, Caulis Spatholobi 10-15 part, Cortex Eucommiae 10-15 part, Radix Rehmanniae Preparata 10-15 part, Radix Glycyrrhizae 10-15 part, Powdered Radix Notoginseng 10-15 part;
Except Powdered Radix Notoginseng, each raw material of all the other ingredients is decocted respectively to twice according to a conventional method, mix decoction liquor twice, add Powdered Radix Notoginseng mix homogeneously, make decoction;
Or according to a conventional method Sanguis Draxonis, the Radix Angelicae Dahuricae are processed into fine powder, Flos Carthami in crude drug, Radix Angelicae Sinensis are extracted respectively to volatile oil, extract medicinal residues and all the other raw material mixing and water adding decocting and concentrating paste making agents after volatile oil, to adding in unguentum, pulverize standby Sanguis Draxonis, the Radix Angelicae Dahuricae, Radix Notoginseng fine powder mix homogeneously, the volatile oil that adds said extracted, mix, practicing honey is ball, makes pill.
2. treatment fracture oral medicine according to claim 1, is characterized in that: the weight part ratio of described crude drug is: Radix Angelicae Sinensis 12g, Rhizoma Corydalis 12 g, Radix Paeoniae Alba 10g, Flos Carthami 10g, Radix Angelicae Dahuricae 12g, Radix Dipsaci 12g, Eupolyphaga Seu Steleophaga 12g, Rhizoma Drynariae 12g, Pyritum 10g, Sanguis Draxonis 10g, Caulis Spatholobi 12g, Cortex Eucommiae 12g, Radix Rehmanniae Preparata 12g, Radix Glycyrrhizae 6g, Powdered Radix Notoginseng 10g.
3. the production method for the treatment of fracture oral medicine according to claim 1, it is characterized in that: the production method of described fracture oral medicine decoction is except Powdered Radix Notoginseng, each raw material of all the other ingredients to be decocted respectively twice according to a conventional method, mix decoction liquor twice, add Powdered Radix Notoginseng mix homogeneously, make decoction.
4. the production method for the treatment of according to claim 1 fracture oral medicine, it is characterized in that: the production method of fracture oral medicine pill is according to a conventional method Sanguis Draxonis, the Radix Angelicae Dahuricae to be processed into fine powder, Flos Carthami in crude drug, Radix Angelicae Sinensis are extracted respectively to volatile oil, extract medicinal residues and all the other raw material mixing and water adding decocting and concentrating paste making agents after volatile oil, to adding in unguentum, pulverize standby Sanguis Draxonis, the Radix Angelicae Dahuricae, Radix Notoginseng fine powder mix homogeneously, the volatile oil that adds said extracted, mix, practicing honey is ball, makes pill.
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| CN104474372B (en) * | 2014-12-07 | 2019-04-23 | 寇威 | A kind of pill and preparation method for fracture surgery rehabilitation medical |
| CN104547794A (en) * | 2015-02-13 | 2015-04-29 | 刘正东 | Traditional Chinese medicine composition for treating bone fracture |
| CN104984183B (en) * | 2015-08-03 | 2018-06-19 | 石忠刚 | A kind of fracture nursing drug |
| CN106729404A (en) * | 2016-12-27 | 2017-05-31 | 山东齐都药业有限公司 | A kind of Chinese medicine preparation and its preparation technology for treating thyroid disease |
| CN110075166A (en) * | 2019-06-10 | 2019-08-02 | 阿拉善盟驼乡兽药有限公司 | A kind of bone-knitting Chinese medicament preparation and preparation method thereof |
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| Title |
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| 关志宇等.活血止痛胶囊处方考证及研究进展.《食品与药品》.2006,第8卷(第02期),17-21. |
| 活血止痛胶囊处方考证及研究进展;关志宇等;《食品与药品》;20060220;第8卷(第02期);17-21 * |
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