CN102274252B - Stauntonvine external applied preparation for treating rheumatoid diseases and preparation method thereof - Google Patents

Stauntonvine external applied preparation for treating rheumatoid diseases and preparation method thereof Download PDF

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CN102274252B
CN102274252B CN201110229016A CN201110229016A CN102274252B CN 102274252 B CN102274252 B CN 102274252B CN 201110229016 A CN201110229016 A CN 201110229016A CN 201110229016 A CN201110229016 A CN 201110229016A CN 102274252 B CN102274252 B CN 102274252B
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caulis
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张晋瑞
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张晋瑞
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Abstract

The invention relates to an external applied preparation for treating rheumatoid diseases, in particular to a stauntonvine external applied preparation for treating rheumatoid diseases. The stauntonvine external applied preparation provided by the invention is prepared from the following raw materials in part by weight: 10 to 100 parts of stauntonvine, and raw materials including eucommia bark, angelica dahurica, ligusticum wallichii, cortex acanthopanacis, clove and the like. The Chinese medicinal materials among the raw materials are washed and used to prepare external applied formulations for treating rheumatoid diseases such as patch and oil. The preparation has a treatment characteristic of external application, has little toxic and side effect, is convent for use, and has an auxiliary treatment effect on rheumatic arthritis, chronic infectious arthritis, diseases in sciatic nerve, sore muscle and the like and has effects of relaxing tendons and activating collaterals.

Description

Treat rheumatoid Caulis et folium stauntoniae external preparation and preparation method thereof
Technical field
The present invention relates to the rheumatoid medicine of a kind of treatment, the rheumatoid Caulis et folium stauntoniae external preparation of especially a kind of treatment the invention still further relates to the method for preparing of this external preparation.
Background technology
Rheumatoid disease is a kind of disease of stubbornness, heals than refractory.Treating this sick Chinese medicine, to adopt decoction oral mostly be main, complete works of like Hu Ximing chief editor's Chinese traditional Chinese medical science secret recipe.Orally-administered decoction uses inconvenient, and Chinese medicine for oral administration is also bigger to the side effect of human body, and reactions such as inappetence, limbs fatigue appear in part patient.
Caulis et folium stauntoniae is a dicotyledon medicine Lardizabalaceae plant, and the Latin formal name used at school is Stauntonia chinensis Decne, is a kind of conventional Chinese medicine; Motherland's its sweet in the mouth of medical science record, flat, GUIXIN, kidney two warps have relaxing muscles and tendons and activating QI and blood in the collateral; To sciatica, muscular soreness has the auxiliary treatment effect.There is the scholar that the chemical constituent of Caulis et folium stauntoniae has been carried out than system, deep research in recent years; Find to contain abundant saponin in the Caulis et folium stauntoniae; Mainly comprise nor-Pentacyclic triterpene saponins compounds and lignanoid's glycosides compound; In addition, also contain flavonoid glycoside compound, phenolic constituent, saccharide compound, multivitamin and several mineral materials etc.Simple acupoint injection therapy stauntonvine injection treatment rheumatoid arthritis is arranged at present; Evident in efficacy, but Caulis et folium stauntoniae uses separately and processes external preparation or Caulis et folium stauntoniae and process external preparation treatment rheumatoid disease with other treatment rheumatoid disease Chinese medicine commonly used couplings and do not have relevant report.
Summary of the invention
The object of the present invention is to provide the rheumatoid Caulis et folium stauntoniae external preparation of a kind of treatment, the invention still further relates to the method for preparing of this external preparation.
Outstanding contributions of the present invention are the rheumatoid conventional Chinese medicine coupling of external preparation or Caulis et folium stauntoniae and other treatment to be processed in the independent use of Caulis et folium stauntoniae process external use plaster; Opened up the application of the new dosage form of Caulis et folium stauntoniae, clinical effectiveness shows that also Caulis et folium stauntoniae has certain curative effect at the external preparation aspect the treatment rheumatoid disease.
Technical scheme of the present invention is:
Treat rheumatoid Caulis et folium stauntoniae external preparation, it contains the medicament that the following weight proportion raw material is processed: Caulis et folium stauntoniae 10-50 part.
Treat rheumatoid Caulis et folium stauntoniae patch, contain the medicament that the following weight proportion raw material is processed: Caulis et folium stauntoniae 10-50 part, Cortex Eucommiae 1-30 part, Radix Angelicae Dahuricae 1-40 part, Radix Clematidis 5-15 part, Camphora 2-8 part, chilli oil 2-8 part.
Treat rheumatoid Caulis et folium stauntoniae external preparation, contain the medicament that the following weight proportion raw material is processed: Caulis et folium stauntoniae 10-50 part, Cortex Eucommiae 1-30 part, Radix Angelicae Dahuricae 1-40 part, Radix Clematidis 5-15 part, Olibanum 5-15 part, Camphora 2-8 part, Borneolum Syntheticum 2-8 part, chilli oil 2-8 part.
Treat rheumatoid Caulis et folium stauntoniae external preparation, contain the medicament that the following weight proportion raw material is processed: 30 parts of Caulis et folium stauntoniaes, 15 parts of the Cortexs Eucommiae, 20 parts of the Radixs Angelicae Dahuricae; 10 parts of Radix Clematidis, 10 parts of Olibanums, 5 parts of Camphoras, 5 parts of Borneolum Syntheticums; 5 parts of chilli oils, 6 parts on Flos Carthami, 6 parts of Radix Angelicae Pubescentiss, 6 parts of the Fructus Kochiae; 3 parts of Rhizoma Chuanxiongs, 3 parts of Cortex Acanthopanciss, 3 parts on Cortex cinnamomi japonici (Ramulus Cinnamomi).
Treat the preparation technology of rheumatoid Caulis et folium stauntoniae patch, have the following steps: the Chinese crude drug in the raw material is cleaned proportional mixing; Pulverize, add in 120 parts of PURs that under 100 ° of C conditions, melt, stirring boiled 30 minutes; Filter; Pour into and process the cream sheet in the doctor knife coater, through tabletting and washer, last packed products.
Treat the preparation technology of rheumatoid Caulis et folium stauntoniae patch, have the following steps: the Chinese crude drug in the raw material is cleaned, proportional mixing, 70% the ethanol that adds 8 times of the medical material gross weight decocts 3 times; Each 30 minutes, merge 3 times decoction liquor, filter, and concentrate; Proportion is 1.10 fluid extract when obtaining 60 ℃, adds 120 parts in the PUR of 100 ° of C fusings, stirs 10 minutes, filters; Pour into and process the cream sheet in the doctor knife coater, through tabletting and washer, last packed products.
Treat the preparation technology of rheumatoid Caulis et folium stauntoniae patch, have the following steps: the Chinese crude drug in the raw material is cleaned, proportional mixing, 8 times the decocting that adds the medical material gross weight boils 3 times; Each 40 minutes, merge 3 times decoction liquor, filter; And concentrate, proportion is 1.10 fluid extract when obtaining 60 ℃, at 40 ° of C stirring in water bath homogeneous; In extractum, add 120 parts of acrylate pressure-sensitive adhesives, 150 r/min stir 30 minutes to evenly, leave standstill the degassing 30 minutes 40 ° of C water-baths; Film,, cover back of the body village after the cooling and get product dry 20 minutes of 80 ° of C; Wherein the polyacrylate pressure-sensitive model is Duro-Tak 87-2677, available from national of the United States's starch company (Shanghai).
Treat the preparation technology of rheumatoid Caulis et folium stauntoniae rheumatism oil, have the following steps: the Chinese crude drug in the raw material is cleaned proportional mixing; The soak with ethanol 30 days that adds 100 part 99%; Cross the filtering solid residue, obtain soak, soak and 40 parts of vegetable oil mix by weight ratio finished product; Wherein vegetable oil comprises: 2 parts of Oleum Cinnamomi, 1 part of Oleum Caryophylli, 1 part of eucalyptus oil, 9 parts of Oleum Terebinthinaes, 27 parts of wintergreen oils.
Caulis et folium stauntoniae external preparation of the present invention is through skin effect administration, and Caulis et folium stauntoniae oral medication rheumatoid is to pass through the administration of blood circulation to whole body again after absorbing through digestive tract, with form of medication of the present invention greatest differences is arranged.
Blood circulation to the whole body administering mode of the percutaneous drug delivery mode of Caulis et folium stauntoniae and Caulis et folium stauntoniae all has and does not have necessary relation between the therapeutic effect.
The invention has the advantages that: therapeutic effect is good, and optimum range is wide, is the treatment characteristic with the external, and toxic and side effects is little, and is easy to use.
Optimum range of the present invention: the present invention is the treatment characteristic with the external; Toxic and side effects is little; Easy to use; Rheumatic arthritis, rheumatoid arthritis, sciatic neuropathy, muscular soreness etc. are had the effect of auxiliary treatment and relaxing muscles and tendons and activating QI and blood in the collateral, particularly rheumatoid arthritis is had certain therapeutic effect.
Therapeutic Method of the present invention:
Rheumatism patch administrated method: the Caulis et folium stauntoniae patch is attached to affected parts such as arthritis sore spot, makes it fit tightly the affected part with the palm applying light, every day a slice.
Rheumatism oil administrated method: Caulis et folium stauntoniae rheumatism oil number droplet is smeared affected parts such as arthritis sore spot; With the position that finger tip is ached in the affected part most, to carry out suitable massage, finger pressure, massage, rub by 2-3 minutes, the light earlier back of dynamics is heavy; Do not feel misery with the patient and be advisable, every day 3 times.
The specific embodiment
Embodiment 1
Treat rheumatoid Caulis et folium stauntoniae external preparation, it contains the medicament that the following weight proportion raw material is processed: 10 parts of Caulis et folium stauntoniaes.
Wherein preparation technology as follows: the Chinese crude drug in the raw material is cleaned, and proportional mixing is pulverized; Add in 120 parts of PURs that under 100 ° of C conditions, melt, stir and boiled filtration 30 minutes; Pour into and process the cream sheet in the doctor knife coater, through tabletting and washer, last packed products.
Embodiment 2
Treat rheumatoid Caulis et folium stauntoniae external preparation, it contains the medicament that the following weight proportion raw material is processed: 30 parts of Caulis et folium stauntoniaes.
Wherein preparation technology is as follows: the Chinese crude drug in the raw material is cleaned, and proportional mixing, 70% the ethanol that adds 8 times of the medical material gross weight decocts each 30 minutes 3 times; Merge 3 times decoction liquor, filter, and concentrate, proportion is 1.10 fluid extract when obtaining 60 ℃; Add 120 parts in the PUR of 100 ° of C fusings, stirred 10 minutes, filter; Pour into and process the cream sheet in the doctor knife coater, through tabletting and washer, last packed products.
Embodiment 3
Treat rheumatoid Caulis et folium stauntoniae external preparation, it contains the medicament that the following weight proportion raw material is processed: 25 parts of Caulis et folium stauntoniaes.
Wherein preparation technology is as follows: the Chinese crude drug in the raw material is cleaned, and proportional mixing, 8 times the decocting that adds the medical material gross weight boils 3 times; Each 40 minutes, merge 3 times decoction liquor, filter; And concentrate, proportion is 1.10 fluid extract when obtaining 60 ℃, at 40 ° of C stirring in water bath homogeneous; In extractum, add 120 parts of acrylate pressure-sensitive adhesives, 150 r/min stir 30 minutes to evenly, leave standstill the degassing 30 minutes 40 ° of C water-baths; Film,, cover back of the body village after the cooling and get product dry 20 minutes of 80 ° of C.
Embodiment 4
Treat rheumatoid Caulis et folium stauntoniae external preparation, it contains the medicament that the following weight proportion raw material is processed: 50 parts of Caulis et folium stauntoniaes.
Wherein preparation technology is as follows: the Chinese crude drug in the raw material is cleaned, and proportional mixing adds 100 part 99% soak with ethanol 30 days, and mistake filtering solid residue obtains soak, soak and 40 parts of vegetable oil mix by weight ratio finished product; Wherein vegetable oil comprises: 2 parts of Oleum Cinnamomi, 1 part of Oleum Caryophylli, 1 part of eucalyptus oil, 9 parts of Oleum Terebinthinaes, 27 parts of wintergreen oils.
Embodiment 5
Treat rheumatoid Caulis et folium stauntoniae patch, contain the medicament that the following weight proportion raw material is processed: 10 parts of Caulis et folium stauntoniaes, 1 part of the Cortex Eucommiae, 1 part of the Radix Angelicae Dahuricae, 5 parts of Radix Clematidis, 2 parts of Camphoras, 2 parts of chilli oils.
Wherein preparation technology is with embodiment 1.
Embodiment 6
Treat rheumatoid Caulis et folium stauntoniae patch, contain the medicament that the following weight proportion raw material is processed: 30 parts of Caulis et folium stauntoniaes, 15 parts of the Cortexs Eucommiae, 20 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Clematidis, 5 parts of Camphoras, 5 parts of chilli oils.
Wherein preparation technology is with embodiment 2.
Embodiment 7
Treat rheumatoid Caulis et folium stauntoniae patch, contain the medicament that the following weight proportion raw material is processed: 25 parts of Caulis et folium stauntoniaes, 20 parts of the Cortexs Eucommiae, 15 parts of the Radixs Angelicae Dahuricae, 8 parts of Radix Clematidis, 6 parts of Camphoras, 6 parts of chilli oils.
Wherein preparation technology is with embodiment 3.
Embodiment 8
Treat rheumatoid Caulis et folium stauntoniae patch, contain the medicament that the following weight proportion raw material is processed: 50 parts of Caulis et folium stauntoniaes, 30 parts of the Cortexs Eucommiae, 40 parts of the Radixs Angelicae Dahuricae, 15 parts of Radix Clematidis, 8 parts of Camphoras, 8 parts of chilli oils.
Wherein preparation technology is with embodiment 4.
Embodiment 9
Treat rheumatoid Caulis et folium stauntoniae external preparation, contain the medicament that the following weight proportion raw material is processed: 10 parts of Caulis et folium stauntoniaes, 1 part of the Cortex Eucommiae, 1 part of the Radix Angelicae Dahuricae, 5 parts of Radix Clematidis, 5 parts of Olibanums, 2 parts of Camphoras, 2 parts of Borneolum Syntheticums, 2 parts of chilli oils.
Wherein preparation technology is with embodiment 1.
Embodiment 10
Treat rheumatoid Caulis et folium stauntoniae external preparation, contain the medicament that the following weight proportion raw material is processed: 30 parts of Caulis et folium stauntoniaes, 15 parts of the Cortexs Eucommiae, 20 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Clematidis, 10 parts of Olibanums, 5 parts of Camphoras, 5 parts of Borneolum Syntheticums, 5 parts of chilli oils.
Wherein preparation technology is with embodiment 2.
Embodiment 11
Treat rheumatoid Caulis et folium stauntoniae external preparation, contain the medicament that the following weight proportion raw material is processed: 25 parts of Caulis et folium stauntoniaes, 20 parts of the Cortexs Eucommiae, 25 parts of the Radixs Angelicae Dahuricae, 8 parts of Radix Clematidis, 8 parts of Olibanums, 6 parts of Camphoras, 6 parts of Borneolum Syntheticums, 6 parts of chilli oils.
Wherein preparation technology is with embodiment 3.
Embodiment 12
Treat rheumatoid Caulis et folium stauntoniae external preparation, contain the medicament that the following weight proportion raw material is processed: 50 parts of Caulis et folium stauntoniaes, 30 parts of the Cortexs Eucommiae, 40 parts of the Radixs Angelicae Dahuricae, 15 parts of Radix Clematidis, 15 parts of Olibanums, 8 parts of Camphoras, 8 parts of Borneolum Syntheticums, 8 parts of chilli oils.
Wherein preparation technology is with embodiment 4.
Embodiment 13
Treat rheumatoid Caulis et folium stauntoniae external preparation, contain the medicament that the following weight proportion raw material is processed: 30 parts of Caulis et folium stauntoniaes, 15 parts of the Cortexs Eucommiae, 20 parts of the Radixs Angelicae Dahuricae; 10 parts of Radix Clematidis, 10 parts of Olibanums, 5 parts of Camphoras, 5 parts of Borneolum Syntheticums; 5 parts of chilli oils, 6 parts on Flos Carthami, 6 parts of Radix Angelicae Pubescentiss, 6 parts of the Fructus Kochiae; 3 parts of Rhizoma Chuanxiongs, 3 parts of Cortex Acanthopanciss, 3 parts on Cortex cinnamomi japonici (Ramulus Cinnamomi).
Wherein preparation technology is as follows: the Chinese crude drug in the raw material is cleaned, and proportional mixing, 70% the ethanol that adds 8 times of the medical material gross weight decocts each 30 minutes 3 times; Merge 3 times decoction liquor, filter, and concentrate, proportion is 1.10 fluid extract when obtaining 60 ℃; Add 120 parts in the PUR of 100 ° of C fusings, stirred 10 minutes, filter; Pour into and process the cream sheet in the doctor knife coater, through tabletting and washer, last packed products.
Efficacy experiment:
Accept 650 routine patients for medical treatment, meet following condition: joint and part muscle swelling, distortion, pain, joint stuffiness, stiff person.Wherein the course of disease is the longest 48 years, minimum 22 years old of age, maximum 79 years old, women 316 people, male 334 people.This 650 routine patient is equally divided into the 1-13 group, and the Caulis et folium stauntoniae external preparation that makes with embodiment 1-13 group is respectively treated.
During the treatment: do not take the rheumatoid Chinese medicine and western medicine of other treatment.
Standards of grading:
Local joint disease is given the classification record: joint stiff time in morning, arthralgia index, joint swelling index, grip.(annotate: index closes joint number * integration for getting involved counts sum).Standards of grading are following: the stiff time in (1) morning: 0 minute: no morning was stiff.1 minute: morning, deadlock was less than 30min.2 minutes: morning, deadlock was greater than 30min, less than 60min.3 minutes: morning, deadlock was greater than 60min.(2) arthralgia integration: 0 minute: no pain.1 minute: mild pain, tell pain during compressing.2 minutes: moderate pain, show painful expression during compressing, shrink back, do not influence sleep.3 minutes: severe pain, the inspection of refusal tenderness, influence sleep.(3) arthroncus integration: 0 minute: no swelling.1 minute: apophysis went out the position near mild swelling, swelling were lower than.2 minutes: it is flat that moderate swelling, swelling and near apophysis go out the position.3 minutes: apophysis went out the position near severe swelling, swelling exceeded.(4) joint allomeric function integration: 0 minute: no joint dysfunction; 1 minute: slight dysfunction, though one or multiarticulate function limitation are arranged, can be engaged in normal activity.2 minutes: moderate joint function disturbance, function of joint were obviously limited, and life still can be taken care of oneself, but can not be engaged in general activity.3 minutes: the severe joint function disturbance, bed or wheelchair can't take care of oneself.
Criterion of therapeutical effect:
Produce effects: observation index treatment back integration summation descends >=70% than the preceding integration summation of treatment.Effectively: observation index treatment back integration summation descends >=50% than the preceding integration summation of treatment, but<70%.Improve: observation index treatment back integration summation descends >=30% than integration summation before treating, but<50%.Invalid: observation index treatment back integration summation descends<30% than the preceding integration summation of treatment.
Integral and calculating: integration summation * 100% before (integration summation before the treatment-treatment back integration summation)/treatment
Therapeutic effect:
Can find out that from efficacy experiment Caulis et folium stauntoniae all has certain curative effect is arranged the treatment rheumatoid disease, particularly the rheumatoid Chinese medicine of Caulis et folium stauntoniae and other treatment is composite, and good especially therapeutic effect is arranged.

Claims (7)

1. the rheumatoid Caulis et folium stauntoniae external preparation of treatment is characterized in that it is made by the following weight proportion raw material: Caulis et folium stauntoniae 10-50 part, Cortex Eucommiae 1-30 part, Radix Angelicae Dahuricae 1-40 part, Radix Clematidis 5-15 part, Camphora 2-8 part, chilli oil 2-8 part.
2. the rheumatoid Caulis et folium stauntoniae external preparation of treatment is characterized in that it is made by the following weight proportion raw material: Caulis et folium stauntoniae 10-50 part, Cortex Eucommiae 1-30 part; Radix Angelicae Dahuricae 1-40 part, Radix Clematidis 5-15 part, Olibanum 5-15 part; Camphora 2-8 part, Borneolum Syntheticum 2-8 part, chilli oil 2-8 part.
3. the rheumatoid Caulis et folium stauntoniae external preparation of treatment is characterized in that it is made by the following weight proportion raw material: 30 parts of Caulis et folium stauntoniaes, 15 parts of the Cortexs Eucommiae, 20 parts of the Radixs Angelicae Dahuricae; 10 parts of Radix Clematidis, 10 parts of Olibanums, 5 parts of Camphoras, 5 parts of Borneolum Syntheticums; 5 parts of chilli oils, 6 parts on Flos Carthami, 6 parts of Radix Angelicae Pubescentiss, 6 parts of the Fructus Kochiae; 3 parts of Rhizoma Chuanxiongs, 3 parts of Cortex Acanthopanciss, 3 parts on Cortex cinnamomi japonici (Ramulus Cinnamomi).
4. like the method for preparing of any rheumatoid Caulis et folium stauntoniae external preparation of treatment among the claim 1-3, it is characterized in that having the following steps: the Chinese crude drug in the raw material is cleaned proportional mixing; Pulverize, add in 120 parts of PURs that under 100 ° of C conditions, melt, stirring boiled 30 minutes; Filter; Pour into and process the cream sheet in the doctor knife coater, through tabletting and washer, last packed products.
5. like the method for preparing of any rheumatoid Caulis et folium stauntoniae external preparation of treatment among the claim 1-3, it is characterized in that having the following steps: the Chinese crude drug in the raw material is cleaned proportional mixing; 70% the ethanol that adds 8 times of the medical material gross weight decocts 3 times, each 30 minutes, merges 3 times decoction liquor; Filter, and concentrate, proportion is 1.10 fluid extract when obtaining 60 ℃; Add 120 parts in the PUR of 100 ° of C fusings, stirred 10 minutes, filter; Pour into and process the cream sheet in the doctor knife coater, through tabletting and washer, last packed products.
6. like the method for preparing of any rheumatoid Caulis et folium stauntoniae external preparation of treatment among the claim 1-3, it is characterized in that having the following steps: the Chinese crude drug in the raw material is cleaned, proportional mixing, 8 times the decocting that adds the medical material gross weight boils 3 times; Each 40 minutes, merge 3 times decoction liquor, filter; And concentrate, proportion is 1.10 fluid extract when obtaining 60 ℃, at 40 ° of C stirring in water bath homogeneous; In extractum, add 120 parts of acrylate pressure-sensitive adhesives, 150 r/min stir 30 minutes to evenly, leave standstill the degassing 30 minutes 40 ° of C water-baths; Film,, cover back of the body village after the cooling and get product dry 20 minutes of 80 ° of C; Wherein the polyacrylate pressure-sensitive model is Duro-Tak 87-2677, available from national of the United States's starch company (Shanghai).
7. like any method for preparing of treating rheumatoid Caulis et folium stauntoniae external preparation among the claim 1-3; It is characterized in that having the following steps: the Chinese crude drug in the raw material is cleaned; Proportional mixing adds 100 part 99% soak with ethanol 30 days, crosses the filtering solid residue; Obtain soak, soak and 40 parts of vegetable oil mix by weight ratio finished product; Wherein vegetable oil comprises: 2 parts of Oleum Cinnamomi, 1 part of Oleum Caryophylli, 1 part of eucalyptus oil, 9 parts of Oleum Terebinthinaes, 27 parts of wintergreen oils.
CN201110229016A 2011-08-11 2011-08-11 Stauntonvine external applied preparation for treating rheumatoid diseases and preparation method thereof Active CN102274252B (en)

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CN103070977B (en) * 2013-02-07 2015-02-04 冀小君 Traditional Chinese medicine composition for treating bone diseases and preparation of traditional Chinese medicine composition
CN106728347B (en) * 2016-11-17 2021-10-26 陕西天森生物工程科技有限公司 Rheumatism liquid and preparation method thereof
CN108498634A (en) * 2017-11-01 2018-09-07 王健民 A kind of externally applied drug of rheumatoid arthritis and its preparation method and application
CN108478645A (en) * 2018-07-04 2018-09-04 尚青青 A kind of Chinese medicine composition and Chinese medicinal liniment and its preparation method and application
CN109464551A (en) * 2018-12-07 2019-03-15 怀化五零三侗医药科技开发有限公司 Wind resistance wet gel and preparation method thereof

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CN1330354C (en) * 2004-01-05 2007-08-08 刘少华 Malus spectabilis snake lice pill
CN100382815C (en) * 2005-05-09 2008-04-23 叶耀良 Compound composition for treating arthralgia caused by wind-dampness and preparation thereof
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Application publication date: 20111214

Assignee: Jiangxi lverkang Medical Devices Co.

Assignor: Zhang Jinrui

Contract record no.: 2013360000091

Denomination of invention: Stauntonvine external applied preparation for treating rheumatoid diseases and preparation method thereof

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License type: Exclusive License

Record date: 20130912