CN101912586B - Medicament for treating mammary gland hyperplasia and preparation method thereof - Google Patents
Medicament for treating mammary gland hyperplasia and preparation method thereof Download PDFInfo
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- CN101912586B CN101912586B CN2010102648538A CN201010264853A CN101912586B CN 101912586 B CN101912586 B CN 101912586B CN 2010102648538 A CN2010102648538 A CN 2010102648538A CN 201010264853 A CN201010264853 A CN 201010264853A CN 101912586 B CN101912586 B CN 101912586B
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Abstract
The invention discloses a medicament for treating mammary gland hyperplasia. The medicament is characterized by being prepared from the following raw materials in part by weight: 1 to 20 parts of rose, 1 to 20 parts of Seville orange flower, 1 to 20 parts of Paris polyphylla Sm., 1 to 20 parts of common selfheal fruit-spike, 1 to 20 parts of barbed skullcap herb, 1 to 20 parts of snakegourd fruit, 1 to 20 parts of seaweed, 1 to 20 parts of kelp, 1 to 20 parts of frankincense, 1 to 20 parts of myrrh, 1 to 20 parts of tangerine leaves, 1 to 20 parts of green tangerine peel, 1 to 20 parts of thunberg fritillary bulb, 1 to 20 parts of common burreed rhizome, 1 to 20 parts of zedoary, 1 to 20 parts of Indian iphigenia bulb, 1 to 20 parts of India madder root, 1 to 20 parts of edible alcohol of which the content is over 95 percent. The medicament can be absorbed by spleen and stomach through oral administration or absorbed by skin through external application and also can be absorbed through the combination of oral administration and external administration. The medicament of the invention has the advantages of reasonable formula, simple compatibility, clear treatment effect and addressing both symptoms and root causes. The invention also provides a preparation method of the medicament.
Description
Technical field
The invention belongs to the field of Chinese medicines, medicine of the treatment cyclomastopathy of particularly a kind of oral administration or external and preparation method thereof.
Background technology
Cyclomastopathy is meant breast epithelium and proliferation of fibrous tissue, mammary gland tissue conduit and the newborn lobule degeneration structurally and the growth of carrying out property connective tissue, and its pathogenic factor mainly is because the endocrine hormone imbalance.Cyclomastopathy is the modal cystic hyperplasia of breast of women, and its sickness rate accounts for the first place of mastopathy.Should be the trend that rises year by year by the disease sickness rate in the last few years, the age also more and more becomes younger.There is 70%～80% women that in various degree cyclomastopathy is all arranged according to investigations approximately, is more common in 25～45 years old women.The symptom of hyperplasia of mammary glands is a feature with breast periodicity pain mainly.Originally overflow the property distending pain for trip, touch a tender spot for the outer upside of breast and middle and upper part for obviously, the pain increased before the menstruation in every month, the back pain of passing through goes down or disappears.Severe patient through preceding through after all be rest pain.Sometimes pain is located radiation to armpit, shoulder back, upper limb etc.
The traditional Chinese medical science thinks, cyclomastopathy is because depressed rage impairing the liver, worry impairing spleen, qi stagnation blood stasis, expectorant congeal into due to the nuclear, and Chinese medicine is referred to as " nodules of the breast ".Liver and kidney two warp and breast relations are the closest, secondly are to dash wantonly two arteries and veins.Stagnation of QI due to depression of the liver, feelings will internal injury have material impact in the pathogenic process of nodules of the breast.Depressed emotion usually, the stagnation of QI do not relax, and QI and blood week loss degree pents up in breast stomach network, and newborn network meridian and vessels obstruction is obstructed, stagnation of QI and blood may bring about pain and cause mastalgia; Liver-QI transversely invading the stomach, dysfunction of the spleen in transportation is given birth in expectorant is turbid, and it is nuclear that qi depression to blood stasis is held the expectorant knot under the arm poly-, follows through staying poly-Ruzhong, so the Ruzhong caking.Deficiency of the liver and kindey, Chong and Ren channel disorder also are the major reasons that causes nodules of the breast.Kidney is a source of vital essence of five ZANG-organs, and kidney qiization is given birth to menses, and menses excites to dash appoints, dash and appoint the following uterus of ing, on connect breast, towards times QI and blood, last behavior breast, following behavior warp.If deficiency of kidney-QI, Chong and Ren channel disorder, QI and blood stagnates, and the long-pending stasis of blood is gathered in breast, uterus, or mastalgia and luming, or disorderly imbalance of menses.
Chinese patent CN200510038869.6 discloses a kind of compound Chinese medicinal preparation for the treatment of cyclomastopathy, be to make active component by the extract or the water extract of the alcohol and water of following raw materials according or following raw materials according, its weight consists of: Pericarpium Citri Reticulatae Viride 300-700, Spica Prunellae 400-800, Bulbus Fritillariae Thunbergii 300-700, Thallus Laminariae (Thallus Eckloniae) 400-800, Olibanum (processed with vinegar) 300-700, make decoction, electuary, capsule, tablet, oral liquid etc.Chinese patent CN200810013922.0 discloses a kind of Chinese prescription for the treatment of cyclomastopathy, and is formulated by following Chinese medicinal raw materials in proportion by weight: Radix Asparagi 6-15g, Radix Bupleuri 6-15g, Radix Paeoniae Alba 6-30g, Cornu Cervi Degelatinatum 6-15g, Radix Morindae Officinalis 10-20g, Rhizoma Curculiginis 6-15g, Radix Angelicae Sinensis 6-20g, Herba Taraxaci 10-50g, Herba Cistanches 10-25g, rhizoma sparganic 6-15g, Rhizoma Curcumae 6-15g, Herba Scutellariae Barbatae 5-20g, Pseudobulbus Cremastrae Seu Pleiones 3-10g, Rhizoma Cyperi 6-15g, Fructus Aurantii Immaturus 6-15g, Pericarpium Citri Reticulatae Viride 6-15g, Radix Curcumae 6-15g, Thallus Laminariae (Thallus Eckloniae) 10-30g, Poria 6-20g makes decoction, capsule, pill.
The Chinese medicine product of above-mentioned treatment cyclomastopathy is paid attention to regulating too much, has reduced the medicine proportion of a therapeutical effect relatively, has influenced the pharmic function performance, so effect is slow, the course of treatment is long, and effect is undesirable.And existing Chinese medicine oral administration but can not external, but can not the taking orally again of external, route of administration is single, makes the patient slow to the absorption of medicine.Chinese medicine for oral administration not only absorbs slowly, and causes spleen injury easily, even increase the weight of the state of an illness for the patient of weakness of the spleen and stomach.
Chinese medicine is taken difficulty owing to mostly be decoction or the pill that boils than Western medicine, has also influenced the popularization of Chinese medicine widely.
Summary of the invention
The objective of the invention is to overcome the defective that prior art exists, a kind of reasonable recipe is provided, compatibility is simplified, the medicine of the treatment cyclomastopathy of determined curative effect, treating both the principal and secondary aspects of a disease, to control, control foster combination, and this medicine can take orally by taste absorb again can external by skin absorbs, can also oral administration and externally used dual mode composite absorption.This compound administering mode helps the efficient absorption of human body to medicine, and for the crowd of weakness of the spleen and stomach, the medicine that is busy with one's work, spares oneself provides multiple choices, especially the patient by the modern job crowd is accepted.
Technical scheme of the present invention is as follows:
A kind of medicine for the treatment of cyclomastopathy is characterized in that it mainly is to be made by the raw material of following weight portion: 1 ~ 20 part of Flos Rosae Rugosae, 1 ~ 20 part of CitrusaurantiumL.Var.amara Engl., 1 ~ 20 part of Rhizoma Paridis, 1 ~ 20 part of Spica Prunellae, 1 ~ 20 part of Herba Scutellariae Barbatae, 1 ~ 20 part of Fructus Trichosanthis, 1 ~ 20 part of Sargassum, 1 ~ 20 part of Thallus Laminariae (Thallus Eckloniae), 1 ~ 20 part of Olibanum, 1 ~ 20 part of Myrrha, 1 ~ 20 part of Folium Citri tangerinae, 1 ~ 20 part on Pericarpium Citri Reticulatae Viride, 1 ~ 20 part of Bulbus Fritillariae Thunbergii, 1 ~ 20 part of rhizoma sparganic, 1 ~ 20 part of Rhizoma Curcumae, 1 ~ 20 part of Pseudobulbus Cremastrae Seu Pleiones, 1 ~ 20 part in Radix Rubiae, 1 ~ 20 part of the edible ethanol of content more than 95%.
Further, the consumption of each component of medicine of the present invention is: 15 ~ 20 parts of Flos Rosae Rugosaes, 15 ~ 20 parts of CitrusaurantiumL.Var.amara Engl.s, 15 ~ 20 parts of Rhizoma Paridis, 15 ~ 20 parts of Spica Prunellaes, 15 ~ 20 parts of Herba Scutellariae Barbataes, 15 ~ 20 parts of Fructus Trichosanthis, 15 ~ 20 parts of Sargassums, 15 ~ 20 parts of Thallus Laminariae (Thallus Eckloniae)s, 15 ~ 20 parts of Olibanums, 15 ~ 20 parts of Myrrhas, 15 ~ 20 parts of Folium Citri tangerinae, 15 ~ 20 parts on Pericarpium Citri Reticulatae Viride, 15 ~ 20 parts of Bulbus Fritillariae Thunbergiis, 15 ~ 20 parts of rhizoma sparganic, 15 ~ 20 parts of Rhizoma Curcumae, 15 ~ 20 parts of Pseudobulbus Cremastrae Seu Pleioness, 15 ~ 20 parts in Radix Rubiae, 15 ~ 20 parts of the edible ethanol of content more than 95%.
The middle survival dose of above compatibility is the crude drug amount.
In order to strengthen the transdermal effect of medicine, can also mix transdermal agent in the medicine of the present invention, preferably weight portion is 1 ~ 5 part a azone.
Another object of the present invention provides manufacturing method for above mentioned medicine, it is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Rhizoma Paridis, Spica Prunellae, Herba Scutellariae Barbatae, Fructus Trichosanthis, Sargassum, Thallus Laminariae (Thallus Eckloniae), Olibanum, Myrrha, Folium Citri tangerinae, Pericarpium Citri Reticulatae Viride, Bulbus Fritillariae Thunbergii, rhizoma sparganic, Rhizoma Curcumae, Pseudobulbus Cremastrae Seu Pleiones and the Radix Rubiae of described weight proportion, according to the conventional extracting method of Chinese medicine, the extract of the former medicine that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add the edible ethanol of content more than 95% of described weight proportion, be mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrate sterilization, fill according to quantity must be treated the medicine of cyclomastopathy.
Further, among the step c, can add in the aqueous solution of alcohol together by azone step a is extract obtained and 1 ~ 5 weight portion.
The conventional extracting method of described Chinese crude drug can adopt decocting method, circumfluence method, infusion process, percolation, semi-bionic extraction, supercritical fluid extraction, microwave extraction method etc. according to the kind of medical material.
The present invention is directed to the characteristics of cyclomastopathy, select Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Rhizoma Paridis, Spica Prunellae, Herba Scutellariae Barbatae, Fructus Trichosanthis, Sargassum, Thallus Laminariae (Thallus Eckloniae), Olibanum, Myrrha, Folium Citri tangerinae, Pericarpium Citri Reticulatae Viride, Bulbus Fritillariae Thunbergii, rhizoma sparganic, Rhizoma Curcumae, Pseudobulbus Cremastrae Seu Pleiones, Radix Rubiae for use, with being that edible ethanol more than 95% mixes with content after each flavor Chinese medicine extraction, make to contain pure Chinese medicine extraction liquid.Employing to be to control, and control and support bonded method, but not only also external of oral administration of the medicine of making is a kind of reasonable recipe, and compatibility is simplified, the medicine of the treatment cyclomastopathy of determined curative effect, treating both the principal and secondary aspects of a disease.
Rhizoma Paridis nature and flavor hardship is slightly cold, and goes into Liver Channel; Heat-clearing and toxic substances removing, detumescence, spasmolytic.The Spica Prunellae liver heat removing, eliminating stagnation is controlled scrofula, goiter, acute mastitis, breast carcinoma, order pearl nyctalgia.The Herba Scutellariae Barbatae heat clearing away, detoxifcation, dissipating blood stasis, hemostasis, analgesic therapy.The Fructus Trichosanthis removing heat from the lung and dissipating phlegm, the promoting the circulation of QI the chest stuffiness relieving; Moistening the lung and resolving phlegm, laxation relieving constipation, mass dissipating and swelling eliminating.The Sargassum softening the hard mass, expectorant, diuretic expels the heat-evil.Thallus Laminariae (Thallus Eckloniae) expectorant knot, the goiter of loosing, inducing diuresis to remove edema.Olibanum suffering, hardship, temperature; GUIXIN, liver, spleen channel; Promoting blood circulation and stopping pain, detumescence and promoting granulation.The Myrrha blood and dissolving stasis that looses, promoting blood circulation and hemostasis, detumescence and promoting granulation.Folium Citri tangerinae is soothing the liver, and circulation of qi promoting is reduced phlegm, and the detumescence poison is controlled hypochondriac pain, acute mastitis, lung abscess, cough, chest and diaphragm feeling of fullness, hernia.The soothing the liver dispelling the stagnated QI of Pericarpium Citri Reticulatae Viride, the eliminating stagnation expectorant is controlled breast side of body gastralgia, hernia, food stagnation, swelling of the breast, nodule in the breast, chronic malaria addiction piece.The Bulbus Fritillariae Thunbergii removing heat-phlegm, powder detoxifcation.The rhizoma sparganic removing blood stasis, circulation of qi promoting, removing food stagnancy, pain relieving.Rhizoma Curcumae circulation of qi promoting removing blood stasis, the removing food stagnancy pain relieving.The Pseudobulbus Cremastrae Seu Pleiones heat-clearing and toxic substances removing, the eliminating carbuncle eliminating stagnation.The Radix Rubiae removing heat from blood and promoting blood circulation, blood stasis dispelling stimulates the menstrual flow.
Cyclomastopathy is formed by depression of liver-QI.The present invention with Rhizoma Paridis, Herba Scutellariae Barbatae with the detumescence tumor; Spica Prunellae, Thallus Laminariae (Thallus Eckloniae), Sargassum hard masses softening and resolving; Rhizoma sparganic, Rhizoma Curcumae, Radix Rubiae, breast do not have, blood circulation promoting and blood stasis dispelling; Fructus Trichosanthis, Bulbus Fritillariae Thunbergii, Pseudobulbus Cremastrae Seu Pleiones dispersing swelling and dissipating binds; Pericarpium Citri Reticulatae Viride, Folium Citri tangerinae breaks hard addiction, and the gas that stagnates that looses is soothing the liver strongly fragrant.It is swollen that through sick institute and disappearing dislikes.The Li Youhong of its hard masses softening and resolving that closes and use.
Flos Rosae Rugosae regulate the flow of vital energy resolving depression and blood dissipating blood stasis; The CitrusaurantiumL.Var.amara Engl. the chest stuffiness relieving of regulating the flow of vital energy, dispersing the stagnated liver-QI for regulating the stomach, appetizing preventing or arresting vomiting.Two medicines, 5 usefulness, a gas one blood, QI and blood is two transfers, eliminating turbid pathogen with aromatics, the appetizing of being amusing, the strength enhancing that absorbs the drug when oral.The edible ethanol blood circulation promoting and blood stasis dispelling of content more than 95% promotes that drug osmotic to cell absorbs, and auxiliary taste absorb to improve curative effect when oral; Outer time spent skin expansion pore is to strengthen the drug transdermal trap.
Medicine of the present invention can be smeared the affected part with medicine of the present invention except for oral administration, and the efficacy of a drug sick institute that goes directly so can remove the patient suffering, obtains and imitates in no time.This medicine is applicable to that also whole body smears.Adopt oral administration and externally usedly, drug effect is more remarkable.
It is obvious that the present invention treats the cyclomastopathy curative effect, and clinical usefulness repeatly, effect are very prompt.Medicine of the present invention is through clinical 78 routine patients' clinical verification, and curing number is 63 examples, and significant figure is 11 examples, and invalid number is 4 examples, and total effective rate reaches 95%.Do not see toxic side effect in the therapeutic process, the patient has better curative effect to obstinate.
For further specifying therapeutic effect, it is as follows now to enumerate model case:
Case 1: certain woman 33 years old, suffer from cyclomastopathy, distending pain of the breast, profile distension.Oral medicine of the present invention, each 10 milliliters, every day 3 times, above symptom was alleviated in 3 days, eliminated in 30 days.Paying a return visit after 6 months does not have recurrence.
Case 2: certain woman 37 years old, suffer from cyclomastopathy, mastalgia, lump is arranged.Once took the Chinese medicine of multiple treatment cyclomastopathy, but effect is all not good.External medicine of the present invention is smeared whole body and chest, and every day 2 times, each 10 milliliters, repeatedly smear at the chest place.Above symptom was alleviated in 2 days, eliminated in 25 days.Paying a return visit after 12 months does not have recurrence.
Case 3: certain woman 35 years old, suffer from cyclomastopathy, periodicity distending pain of the breast, upper limb radiating pain.Once took the Chinese medicine of multiple treatment cyclomastopathy, but effect is all not good.Oral medicine of the present invention, each 10 milliliters, every day 3 times; This medicine of external is smeared whole body and chest, and every day 2 times, each 10 milliliters, repeatedly smear at the breast place.Above symptom is oral to be alleviated with external in 1 day, eliminated in 20 days.Paying a return visit after 12 months does not have recurrence.
The specific embodiment
Embodiment 1
Take by weighing 15 parts of Flos Rosae Rugosaes, 18 parts of CitrusaurantiumL.Var.amara Engl.s, 15 parts of Rhizoma Paridis, 16 parts of Spica Prunellaes, 17 parts of Herba Scutellariae Barbataes, 18 parts of Fructus Trichosanthis, 19 parts of Sargassums, 19 parts of Thallus Laminariae (Thallus Eckloniae)s, 18 parts of Olibanums, 20 parts of Myrrhas, 20 parts of Folium Citri tangerinae, 17 parts on Pericarpium Citri Reticulatae Viride, 17 parts of Bulbus Fritillariae Thunbergiis, 15 parts of rhizoma sparganic, 15 parts of Rhizoma Curcumae, 16 parts of Pseudobulbus Cremastrae Seu Pleioness, 20 parts in Radix Rubiae adopts the method that decocts the back concentrating under reduced pressure to make Chinese medicine extract respectively, and is standby.
Under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add content and be 18 parts of 96% edible ethanols, be mixed with aqueous solution of alcohol, standby.
Above-mentioned various Chinese medicine extract are added in the aqueous solution of alcohol, fully stirred 120 minutes, precipitate 2 ~ 4 hours, supernatant 200 orders filter, and gained filtrate is the medicine of the treatment cyclomastopathy of oral administration or external, carries out fill under aseptic condition.Gained precipitate and filtering residue focus on.
Embodiment 2
The drug component proportioning is: 18 parts of Flos Rosae Rugosaes, 19 parts of CitrusaurantiumL.Var.amara Engl.s, 20 parts of Rhizoma Paridis, 20 parts of Spica Prunellaes, 19 parts of Herba Scutellariae Barbataes, 18 parts of Fructus Trichosanthis, 18 parts of Sargassums, 18 parts of Thallus Laminariae (Thallus Eckloniae)s, 19 parts of Olibanums, 20 parts of Myrrhas, 19 parts of Folium Citri tangerinae, 18 parts on Pericarpium Citri Reticulatae Viride, 18 parts of Bulbus Fritillariae Thunbergiis, 20 parts of rhizoma sparganic, 18 parts of Rhizoma Curcumae, 18 parts of Pseudobulbus Cremastrae Seu Pleioness, 18 parts in Radix Rubiae, content is 18 parts of 97% edible ethanols.Other is identical with embodiment 1.
Embodiment 3
The drug component proportioning is: 19 parts of Flos Rosae Rugosaes, 20 parts of CitrusaurantiumL.Var.amara Engl.s, 20 parts of Rhizoma Paridis, 20 parts of Spica Prunellaes, 20 parts of Herba Scutellariae Barbataes, 20 parts of Fructus Trichosanthis, 19 parts of Sargassums, 18 parts of Thallus Laminariae (Thallus Eckloniae)s, 18 parts of Olibanums, 19 parts of Myrrhas, 19 parts of Folium Citri tangerinae, 18 parts on Pericarpium Citri Reticulatae Viride, 18 parts of Bulbus Fritillariae Thunbergiis, 20 parts of rhizoma sparganic, 20 parts of Rhizoma Curcumae, 19 parts of Pseudobulbus Cremastrae Seu Pleioness, 18 parts in Radix Rubiae, content is 18 parts of 98% edible ethanols.Other is identical with embodiment 1.
Embodiment 4
The drug component proportioning is: 16 parts of Flos Rosae Rugosaes, 17 parts of CitrusaurantiumL.Var.amara Engl.s, 17 parts of Rhizoma Paridis, 18 parts of Spica Prunellaes, 16 parts of Herba Scutellariae Barbataes, 16 parts of Fructus Trichosanthis, 17 parts of Sargassums, 16 parts of Thallus Laminariae (Thallus Eckloniae)s, 17 parts of Olibanums, 18 parts of Myrrhas, 15 parts of Folium Citri tangerinae, 15 parts on Pericarpium Citri Reticulatae Viride, 16 parts of Bulbus Fritillariae Thunbergiis, 18 parts of rhizoma sparganic, 17 parts of Rhizoma Curcumae, 16 parts of Pseudobulbus Cremastrae Seu Pleioness, 15 parts in Radix Rubiae, content is 16 parts of 99% edible ethanols.Other is identical with embodiment 1.
Embodiment 5
The drug component proportioning is: 17 parts of Flos Rosae Rugosaes, 18 parts of CitrusaurantiumL.Var.amara Engl.s, 19 parts of Rhizoma Paridis, 19 parts of Spica Prunellaes, 18 parts of Herba Scutellariae Barbataes, 17 parts of Fructus Trichosanthis, 18 parts of Sargassums, 19 parts of Thallus Laminariae (Thallus Eckloniae)s, 19 parts of Olibanums, 18 parts of Myrrhas, 15 parts of Folium Citri tangerinae, 16 parts on Pericarpium Citri Reticulatae Viride, 17 parts of Bulbus Fritillariae Thunbergiis, 16 parts of rhizoma sparganic, 18 parts of Rhizoma Curcumae, 18 parts of Pseudobulbus Cremastrae Seu Pleioness, 19 parts in Radix Rubiae, content is 19 parts of 100% edible ethanols.Other is identical with embodiment 1.
Embodiment 6
The drug component proportioning is: 19 parts of Flos Rosae Rugosaes, 20 parts of CitrusaurantiumL.Var.amara Engl.s, 20 parts of Rhizoma Paridis, 20 parts of Spica Prunellaes, 18 parts of Herba Scutellariae Barbataes, 17 parts of Fructus Trichosanthis, 19 parts of Sargassums, 19 parts of Thallus Laminariae (Thallus Eckloniae)s, 20 parts of Olibanums, 18 parts of Myrrhas, 19 parts of Folium Citri tangerinae, 18 parts on Pericarpium Citri Reticulatae Viride, 18 parts of Bulbus Fritillariae Thunbergiis, 16 parts of rhizoma sparganic, 18 parts of Rhizoma Curcumae, 19 parts of Pseudobulbus Cremastrae Seu Pleioness, 18 parts in Radix Rubiae, content is 20 parts of 97% edible ethanols.Other is identical with embodiment 1.
Claims (4)
1. medicine for the treatment of cyclomastopathy, it is characterized in that it is to be made by the raw material of following weight portion: 15 ~ 20 parts of Flos Rosae Rugosaes, 15 ~ 20 parts of CitrusaurantiumL.Var.amara Engl.s, 15 ~ 20 parts of Rhizoma Paridis, 15 ~ 20 parts of Spica Prunellaes, 15 ~ 20 parts of Herba Scutellariae Barbataes, 15 ~ 20 parts of Fructus Trichosanthis, 15 ~ 20 parts of Sargassums, 15 ~ 20 parts of Thallus Laminariae (Thallus Eckloniae)s, 15 ~ 20 parts of Olibanums, 15 ~ 20 parts of Myrrhas, 15 ~ 20 parts of Folium Citri tangerinae, 15 ~ 20 parts on Pericarpium Citri Reticulatae Viride, 15 ~ 20 parts of Bulbus Fritillariae Thunbergiis, 15 ~ 20 parts of rhizoma sparganic, 15 ~ 20 parts of Rhizoma Curcumae, 15 ~ 20 parts of Pseudobulbus Cremastrae Seu Pleioness, 15 ~ 20 parts of 15 ~ 20 parts in Radix Rubiae, the content edible ethanols more than 95%.
2. a medicine for the treatment of cyclomastopathy is characterized in that, it is that to also have weight portion on the raw material basis of the described weight portion of claim 1 be that 1 ~ 5 part azone is made.
3. the preparation method of the described medicine of claim 1 is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Rhizoma Paridis, Spica Prunellae, Herba Scutellariae Barbatae, Fructus Trichosanthis, Sargassum, Thallus Laminariae (Thallus Eckloniae), Olibanum, Myrrha, Folium Citri tangerinae, Pericarpium Citri Reticulatae Viride, Bulbus Fritillariae Thunbergii, rhizoma sparganic, Rhizoma Curcumae, Pseudobulbus Cremastrae Seu Pleiones and the Radix Rubiae of described weight proportion, according to the conventional extracting method of Chinese medicine, the extract of the raw material that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add the edible ethanol of content more than 95% of described weight proportion, be mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrate sterilization, fill according to quantity must be treated the medicine of cyclomastopathy.
4. the preparation method of the described medicine of claim 2 is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Rhizoma Paridis, Spica Prunellae, Herba Scutellariae Barbatae, Fructus Trichosanthis, Sargassum, Thallus Laminariae (Thallus Eckloniae), Olibanum, Myrrha, Folium Citri tangerinae, Pericarpium Citri Reticulatae Viride, Bulbus Fritillariae Thunbergii, rhizoma sparganic, Rhizoma Curcumae, Pseudobulbus Cremastrae Seu Pleiones and the Radix Rubiae of described weight proportion, according to the conventional extracting method of Chinese medicine, the extract of the raw material that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add the edible ethanol of content more than 95% of described weight proportion, be mixed with aqueous solution of alcohol;
C) azone step a is extract obtained and described weight proportion adds in the aqueous solution of alcohol together, stirs 120 minutes, precipitates 2 ~ 4 hours, filter, and gained filtrate sterilization, fill according to quantity must be treated the medicine of cyclomastopathy.
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| CN103007022B (en) * | 2012-11-22 | 2014-12-31 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating mastitis of dairy cows and preparation method of composition |
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| CN1261146C (en) * | 2003-10-08 | 2006-06-28 | 贾青宁 | Plaster for treating hyperplasia of mammary glands |
| CN100345574C (en) * | 2005-01-14 | 2007-10-31 | 赵庆丽 | Medicine composition for treating cyclomastopathy |
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